Detailed view for Tb11.01.0355

Basic information

TDR Targets ID: 10149
Trypanosoma brucei, ribosomal protein S26, putative
Source Database / ID: GeneDB / Tb11.01.0355

pI: 11.9 | Length (AA): 111 | MW (Da): 12806 | Number of Paralogs: 1 | -.-.-.-

Signal peptide: N | GPI Anchor: N (Show evidence) | Predicted trans-membrane segments: 0

Pfam domains

PF01283   Ribosomal protein S26e

Gene Ontology

Biological Process:
GO:0006412   translation   [+/–] show term definition

The chemical reactions and pathways resulting in the formation of a protein. This is a ribosome-mediated process in which the information in messenger RNA (mRNA) is used to specify the sequence of amino acids in the protein.

Cellular component:
GO:0005840   ribosome   [+/–] show term definition

An intracellular organelle, about 200 A in diameter, consisting of RNA and protein. It is the site of protein biosynthesis resulting from translation of messenger RNA (mRNA). It consists of two subunits, one large and one small, each containing only protein and RNA. Both the ribosome and its subunits are characterized by their sedimentation coefficients, expressed in Svedberg units (symbol: S). Hence, the prokaryotic ribosome (70S) comprises a large (50S) subunit and a small (30S) subunit, while the eukaryotic ribosome (80S) comprises a large (60S) subunit and a small (40S) subunit. Two sites on the ribosomal large subunit are involved in translation, namely the aminoacyl site (A site) and peptidyl site (P site). Ribosomes from prokaryotes, eukaryotes, mitochondria, and chloroplasts have characteristically distinct ribosomal proteins." [ISBN:0198506732 "Oxford Dictionary of Biochemistry and Molecular Biology

GO:0005622   intracellular   [+/–] show term definition

Molecular Function:
GO:0003735   structural constituent of ribosome   [+/–] show term definition

The action of a molecule that contributes to the structural integrity of the ribosome.

Metabolic Pathways

Ribosome (KEGG)

Functional classes

GO:0005198 structural molecule activity
GO:0009987 cellular process

Structural information

Modbase 3D models: no model available for this protein in Modbase.

PDB structures: no structure available for this protein in the PDB.

Expression

No expression information available for this gene.

Antigenicity

Number of putative antigenic epitopes: 6
Cumulative epitope score: 6.8
Normalized epitope score: 6.1
Percentile: 98.0 (this protein belongs to the top 2.0% proteins in the genome of Trypanosoma brucei, based on the predicted antigenicity).

[+/–]   More information on this prediction ...

Orthologs

OrthoMCL cluster: OG1.2_873
Number of Paralogs: 1
Arabidopsis thaliana At3g56340.1   |   OrthoMCL
Arabidopsis thaliana At2g40510.1   |   OrthoMCL
Arabidopsis thaliana At2g40590.1   |   OrthoMCL
Brugia malayi Bm1_00185   |   OrthoMCL
Caenorhabditis elegans F39B2.6   |   OrthoMCL
Drosophila melanogaster CG10305-PA   |   OrthoMCL
Drosophila melanogaster CG10305-PB   |   OrthoMCL
Drosophila melanogaster CG10305-PC   |   OrthoMCL
Homo sapiens ENSP00000348580   |   OrthoMCL
Homo sapiens ENSP00000350790   |   OrthoMCL
Homo sapiens ENSP00000348849   |   OrthoMCL
Homo sapiens ENSP00000350128   |   OrthoMCL
Homo sapiens ENSP00000353727   |   OrthoMCL
Leishmania major LmjF30.3200   |   OrthoMCL
Leishmania major LmjF28.0540   |   OrthoMCL
Mus musculus ENSMUSP00000076447   |   OrthoMCL
Mus musculus ENSMUSP00000026420   |   OrthoMCL
P. falciparum 3D7 PFB0830w   |   OrthoMCL
Plasmodium vivax Pv002650   |   OrthoMCL
Saccharomyces cerevisiae YGL189C   |   OrthoMCL
Saccharomyces cerevisiae YER131W   |   OrthoMCL
Schistosoma mansoni Smp_031310   |   OrthoMCL
Schistosoma mansoni Smp_183650   |   OrthoMCL
Trypanosoma brucei Tb11.01.0355 (this record).   |   OrthoMCL
Trypanosoma cruzi Tc00.1047053508817.60
Trypanosoma cruzi Tc00.1047053503801.20
Toxoplasma gondii 49.m03356   |   OrthoMCL

Essentiality Tb11.01.0355 has essentiality data
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Embryonic Lethal/Arrest; Source study: neb
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Larval/Adult Lethal/Arrest; Source study: neb
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Sterility; Source study: neb
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Morphology Defect; Source study: neb
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Embryonic Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Larval/Adult Lethal/Arrest; Source study: wormbase
Gene/Ortholog: cel8563 (OG1.2_873); Phenotype: Sterility; Source study: wormbase

[+/–]   Show essentiality data references.

Phenotypes (curated)

No manually curated information for this target.

Druggability

Mean compound desirability (max is 1):
Mean number of compounds:

Associated compounds

Note: at this moment the information about chemical compounds linked to a gene, and the literature references associated with each gene are coming from a semi-automated scanning of a relevant subset of the literature. Manual curation for all target species is ongoing.

Do send us a note: if you have information about compounds for this gene.

No chemical compound is associated with this gene.

If you have information about compounds for this gene, please enter them in a user comment (see below) or contact us.

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic references

No literature references are available for this gene.

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User comments

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