Detailed view for mal_mito_2

Basic information

TDR Targets ID: 321968
Plasmodium falciparum, cytochrome c oxidase subunit 1
Source Database / ID:  PlasmoDB   |   GeneDB   |   MPMP

pI: 7.1699 | Length (AA): 508 | MW (Da): 56413 | Paralog Number: 0

Signal peptide: N | GPI Anchor: N | Predicted trans-membrane segments: 13

Druggability Group : DG3

Targets have been classified into druggability groups (DG) according to their druggability score in network driven prioritizations. DGs range from 1 to 5; the higher the group number, the higher the chance of the target to be druggable

Pfam domains

PF00115   Cytochrome C and Quinol oxidase polypeptide I

Gene Ontology

Mouse over links to read term descriptions.
GO:0016021   integral to membrane  
GO:0020037   heme binding  
GO:0009055   electron carrier activity  
GO:0005506   iron ion binding  
GO:0004129   cytochrome-c oxidase activity  
GO:0055114   oxidation reduction  
GO:0009060   aerobic respiration  

Metabolic Pathways

This gene is not mapped to any metabolic pathway in KEGG.

Structural information

Modbase 3D models:

There are 3 models calculated for this protein. More info on these models, including the models themselves is available at: Modbase

Target Beg Target End Template Template Beg Template End Identity Evalue Model Score MPQS zDope
4 477 3dtu (A) 16 511 38.00 0.00000000015 1 1.40183 -0.35
5 476 3ag2 (A) 3 467 47.00 0 1 1.63305 -1.03
35 506 3ag2 (A) 3 467 47.00 0 1 1.57553 -1.03

Help me make sense of these data.

Target Beg: first modeled residue
Target End: last modeled residue
Template: template structure used for modelling (PDB accession and chain)
Template Beg: first template residue in target-template alignment
Template End: last template residue in target-template alignment
Identity: sequence identity
Evalue: E value for target-template hit
Model Score: GA341 score (>0.7 for reliable model)
MPQS: ModPipe Quality Score (>1.1 for reliable model)
zDope: zDope Score (negative for reliable model)

A more detailed description of these scores is available at the Modbase Model Evaluation Help Pages, and in the papers referenced therein.

PDB Structures:

No structure availble in the PDB for this protein

Expression

Upregulation Percent Ranking Stage Dataset
Upper 80-100% percentile intra-erythrocytic - 0 hs, intra-erythrocytic - 8 hs, intra-erythrocytic - 16 hs, intra-erythrocytic - 24 hs, intra-erythrocytic - 32 hs, intra-erythrocytic - 40 hs, intra-erythrocytic - 48 hs, Oocyst, Ring, Sporozoite, Female Gametocyte. Otto TD Zanghi G Lasonder E
Upregulation Percent Ranking Stage Dataset
Mid 40-60% percentile Male Gametocyte. Lasonder E
Show/Hide expression data references
  • Otto TD New insights into the blood-stage transcriptome of Plasmodium falciparum using RNA-Seq.
  • Lasonder E Integrated transcriptomic and proteomic analyses of P. falciparum gametocytes. Molecular insight into sex-specific processes and translational repression.
  • Zanghi G A Specific PfEMP1 Is Expressed in P. falciparum Sporozoites and Plays a Role in Hepatocyte Infection.

Orthologs

Ortholog group members (OG5_128358)

Species Accession Gene Product
Arabidopsis thaliana ArthMp109   cytochrome c oxidase subunit 1
Babesia bovis BBOV_VI000010   cytochrome c oxidase subunit I
Dictyostelium discoideum DidioMp06   cytochrome oxidase subunit 1 and subunit 2
Escherichia coli b0431   cytochrome o ubiquinol oxidase subunit I
Echinococcus granulosus EgrG_900000800   cytochrome c oxidase subunit 1
Homo sapiens 4512   cytochrome c oxidase subunit I
Mycobacterium leprae ML1728c   PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1)
Mus musculus 17708   cytochrome c oxidase subunit I
Mycobacterium tuberculosis Rv3043c   Probable cytochrome C oxidase polypeptide I CtaD (cytochrome AA3 subunit 1)
Mycobacterium ulcerans MUL_1333   cytochrome C oxidase polypeptide I CtaD
Mycobacterium ulcerans MUL_1887   cytochrome C oxidase polypeptide I CtaD
Neospora caninum NCLIV_068790   Cytochrome c oxidase subunit 1 (EC 1.9.3.1), related
Oryza sativa 6450122   cytochrome c oxidase subunit1
Onchocerca volvulus OVOC2859  
Onchocerca volvulus OVOC12628   Cytochrome c oxidase subunit 1 homolog
Plasmodium berghei PBANKA_MIT01800   cytochrome c oxidase subunit I
Plasmodium falciparum mal_mito_2   cytochrome c oxidase subunit 1
Plasmodium knowlesi PKNH_MIT01800   cytochrome c oxidase subunit I
Plasmodium vivax PVAD80_MIT0002   cytochrome c oxidase subunit I
Plasmodium yoelii PY00775   cytochrome c oxidase subunit 1
Plasmodium yoelii PY00149   cytochrome c oxidase subunit I-related
Saccharomyces cerevisiae Q0070   intron-encoded DNA endonuclease aI5 alpha
Saccharomyces cerevisiae Q0045   cytochrome c oxidase subunit 1
Schistosoma japonicum Sjp_0124600   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0127360   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0129860   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0124510   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0122980   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0126060   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0126810   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0118860   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0130060   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0125530   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0126290   ko:K02256 cytochrome c oxidase subunit I, putative
Schistosoma japonicum Sjp_0127400   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0124240   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0124630   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0125790   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0128790   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0129770   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0127100   Cytochrome c oxidase subunit 1, putative
Schistosoma japonicum Sjp_0124300   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0125170   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0125180   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0123240   IPR000883,Cytochrome c oxidase, subunit I,domain-containing
Schistosoma japonicum Sjp_0123700   Cytochrome c oxidase subunit 1, putative
Schistosoma mansoni Smp_184920   cytochrome oxidase subunit
Schistosoma mansoni Smp_110870   cytochrome oxidase subunit
Schistosoma mansoni Smp_184440   cytochrome oxidase subunit
Schistosoma mansoni Smp_184550   cytochrome oxidase subunit
Schmidtea mediterranea mk4.040315.00   Cytochrome c oxidase subunit 1
Schmidtea mediterranea mk4.000026.07  
Theileria parva Tpmp1   cytochrome oxidase subunit I
Wolbachia endosymbiont of Brugia malayi Wbm0307   cytochrome c oxidase, subunit 1

Essentiality

mal_mito_2 has one or more orthologs with essentiality data
Gene/Ortholog Organism Phenotype Source Study
b0431 Escherichia coli non-essential goodall
Show/Hide essentiality data references
  • sidik A Genome-wide CRISPR Screen in Toxoplasma Identifies Essential Apicomplexan Genes. Sidik, Saima M., et al. "A genome-wide CRISPR screen in toxoplasma identifies essential apicomplexan genes." Cell 166.6 (2016): 1423-1435.
  • wormbase C. elegans RNAi experiments WormBase web site, http://www.wormbase.org, release WS170
  • gerdes Experimental determination and system-level analysis of essential genes in E. coli MG1655 Gerdes et al., J Bacteriol. 2003 185:5673-84
  • keio Systematic single-gene knock-out mutants of E. coli K12 The Keio Collection
  • nmpdr Genome-scale essentiality datasets from published studies (M. tuberculosis) National Microbial Pathogen Data Resource
  • goodall The Essential Genome of Escherichia coli K-12 (Transposon directed high-throughput mutagenesis) Goodall, Emily CA, et al. "The essential genome of Escherichia coli K-12." mBio 9.1 (2018): e02096-17.
  • yeastgenome Systematic deletion of yeast genes Saccharomyces Genome Database
  • alsford High-throughput phenotyping using parallel sequencing of RNA interference targets in the African trypanosome Genome Res 2011, 21:915-924
  • blattner Systematic mutagenesis of the E. coli (MG1655) genome J Bacteriol 2004, 186:4921-4930
  • plasmo Functional Profiling of a Plasmodium Genome Reveals an Abundance of Essential Genes. Bushell, Ellen, et al. "Functional profiling of a Plasmodium genome reveals an abundance of essential genes." Cell 170.2 (2017): 260-272.
  • shigen Profiling of E. coli Chromosome (PEC) National Institute of Genetics, Japan
  • neb C. elegans RNAi phenotypes Data obtained from Wormbase WS150, curated by K. Chaudary and T. Carlow, New England Biolabs

Phenotypes and Validation (curated)

We have no manually annotated phenotypes for this target. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please contact us.

Annotated validation

No validation data for this target

Associated compounds / Druggability

Known modulators for this target

No chemical compounds associated to this gene

Predicted associations

By orthology with druggable targets
Species Known druggable target Linked compounds Reference
Homo sapiens cytochrome c oxidase subunit I Compounds References
Mycobacterium leprae PROBABLE CYTOCHROME C OXIDASE POLYPEPTIDE I CTAD (CYTOCHROME AA3 SUBUNIT 1) Compounds References
Ovis aries Cytochrome c oxidase subunit 1 Compounds References
By sequence similarity to non orthologous druggable targets
No additional associated druggable targets
Obtained from network model

Ranking Plot

Putative Drugs List

Compound Raw Global Species
0.0167 0.2692 1
0.0156 0.3936 1

Assayability

Assay information

No assay information for this target.

Reagent availability

No reagent availability information for this target.

Bibliographic References

No literature references available for this target.

If you have references for this gene, please enter them in a user comment (below) or Contact us.

User comments

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Gene identifier mal_mito_2 (Plasmodium falciparum), cytochrome c oxidase subunit 1
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