Detailed information for compound 119794

Basic information

Technical information
  • TDR Targets ID: 119794
  • Name: artemisinine
  • MW: 282.332 | Formula: C15H22O5
  • H donors: 0 H acceptors: 1 LogP: 2.79 Rotable bonds: 0 Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1O[C@@H]2O[C@]3(C)CC[C@@H]4[C@]2([C@H]([C@H]1C)CC[C@H]4C)OO3
  • InChi: 1S/C15H22O5/c1-8-4-5-11-9(2)12(16)17-13-15(11)10(8)6-7-14(3,18-13)19-20-15/h8-11,13H,4-7H2,1-3H3/t8-,9-,10+,11+,13-,14+,15-/m1/s1
  • InChiKey: BLUAFEHZUWYNDE-DKGJTOOQSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens TAR DNA binding protein Starlite/ChEMBL References
Plasmodium falciparum dihydroorotate dehydrogenase Starlite/ChEMBL References
Homo sapiens APEX nuclease (multifunctional DNA repair enzyme) 1 Starlite/ChEMBL References
Influenza A virus Nonstructural protein 1 Starlite/ChEMBL References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 Starlite/ChEMBL References
Trypanosoma cruzi plasma membrane Ca2+ ATPase Curated by TDR Targets References
Saccharomyces cerevisiae dihydroorotate dehydrogenase Starlite/ChEMBL References
Homo sapiens ubiquitin specific peptidase 1 Starlite/ChEMBL References
Trypanosoma cruzi plasma membrane Ca2+ ATPase Curated by TDR Targets References
Homo sapiens cytochrome P450, family 2, subfamily B, polypeptide 6 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Plasmodium knowlesi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium vivax dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii exonuclease III APE Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) calcium ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei vacuolar-type Ca2+-ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum Plasma membrane calcium-transporting ATPase 3, putative Get druggable targets OG5_126645 All targets in OG5_126645
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Echinococcus granulosus tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania mexicana vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi dihydroorotate dehydrogenase (fumarate), putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania infantum apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni plasma membrane calcium-transporting atpase Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma mansoni dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) calcium ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma congolense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Plasmodium berghei dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Entamoeba histolytica plasma membrane calcium-transporting ATPase 1, putative Get druggable targets OG5_126645 All targets in OG5_126645
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma brucei vacuolar-type Ca2+-ATPase 1 Get druggable targets OG5_126645 All targets in OG5_126645
Plasmodium falciparum dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma cruzi plasma membrane Ca2+ ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) TAR-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Candida albicans possible calcium transporter Get druggable targets OG5_126645 All targets in OG5_126645
Brugia malayi RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Echinococcus multilocularis Tetracycline resistance leader peptide, TetL Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) RNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania major dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma japonicum Plasma membrane calcium-transporting ATPase 3, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium berghei AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Cryptosporidium hominis dna-(apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica exodeoxyribonuclease III, putative Get druggable targets OG5_126768 All targets in OG5_126768
Entamoeba histolytica plasma membrane calcium ion-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) exodeoxyribonuclease III family protein Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans possible calcium transporter Get druggable targets OG5_126645 All targets in OG5_126645
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum TAR DNA-binding protein 43, putative Get druggable targets OG5_132461 All targets in OG5_132461
Schistosoma japonicum ko:K10771 AP endonuclease 1, putative Get druggable targets OG5_126768 All targets in OG5_126768
Echinococcus granulosus Ca2 transporting ATPase plasma membrane Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania donovani P-type ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania infantum P-type ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma cruzi apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K00226 dihydroorotate oxidase [EC1.3.3.1], putative Get druggable targets OG5_127289 All targets in OG5_127289
Echinococcus granulosus plasma membrane calcium transporting ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Neospora caninum hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis cation-transporting ATPase fungi, putative Get druggable targets OG5_126645 All targets in OG5_126645
Plasmodium knowlesi AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Plasmodium yoelii putative AP endonuclease-related Get druggable targets OG5_126768 All targets in OG5_126768
Brugia malayi Membrane calcium atpase protein 3 Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania major vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Toxoplasma gondii plasma membrane-type Ca(2+)-ATPase A1 PMCAA1 Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum Plasma membrane calcium-transporting ATPase 2, putative Get druggable targets OG5_126645 All targets in OG5_126645
Echinococcus multilocularis plasma membrane calcium transporting ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma brucei gambiense vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Neospora caninum dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Neospora caninum hypothetical protein Get druggable targets OG5_126645 All targets in OG5_126645
Treponema pallidum exodeoxyribonuclease (exoA) Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K05850 Ca2+ transporting ATPase, plasma membrane, putative Get druggable targets OG5_126645 All targets in OG5_126645
Brugia malayi calcium ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Cryptosporidium parvum conserved hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Echinococcus multilocularis Ca2+ transporting ATPase plasma membrane Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania major P-type ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum Plasma membrane calcium-transporting ATPase 3, putative Get druggable targets OG5_126645 All targets in OG5_126645
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum DNA-(apurinic or apyrimidinic site) lyase 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trichomonas vaginalis ap endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania major apurinic/apyrimidinic endonuclease-redox protein Get druggable targets OG5_126768 All targets in OG5_126768
Trypanosoma cruzi plasma membrane Ca2+ ATPase Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma cruzi dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Babesia bovis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum dihydroorotate dehydrogenase;with=GeneDB:LmjF16.0530 Get druggable targets OG5_127289 All targets in OG5_127289
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania mexicana apurinic/apyrimidinic endonuclease-redox protein,AP-endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania mexicana dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma japonicum Plasma membrane calcium-transporting ATPase 3, putative Get druggable targets OG5_126645 All targets in OG5_126645
Neospora caninum hypothetical protein Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Trypanosoma brucei dihydroorotate dehydrogenase (fumarate) Get druggable targets OG5_127289 All targets in OG5_127289
Echinococcus granulosus plasma membrane calcium transporting ATPase 2 Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Leishmania braziliensis dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma congolense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania donovani dihydroorotate dehydrogenase Get druggable targets OG5_127289 All targets in OG5_127289
Toxoplasma gondii dihydroorotate dehydrogenase reveal, putative Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis P-type ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Brugia malayi RNA recognition motif domain containing protein Get druggable targets OG5_132461 All targets in OG5_132461
Mycobacterium ulcerans dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Wolbachia endosymbiont of Brugia malayi dihydroorotate dehydrogenase 2 Get druggable targets OG5_127289 All targets in OG5_127289
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma mansoni plasma membrane calcium-transporting atpase Get druggable targets OG5_126645 All targets in OG5_126645
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma japonicum ko:K10772 AP endonuclease 2, putative Get druggable targets OG5_126768 All targets in OG5_126768
Giardia lamblia Plasma membrane calcium-transporting ATPase 2 Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania braziliensis vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Mycobacterium leprae Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Brugia malayi Dihydroorotate dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_127289 All targets in OG5_127289
Trypanosoma brucei vacuolar-type Ca2+-ATPase 2 Get druggable targets OG5_126645 All targets in OG5_126645
Entamoeba histolytica Plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma congolense vacuolar-type Ca2+-ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma brucei gambiense apurinic/apyrimidinic endonuclease, putative Get druggable targets OG5_126768 All targets in OG5_126768
Theileria parva hypothetical protein Get druggable targets OG5_126768 All targets in OG5_126768
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative Get druggable targets OG5_126768 All targets in OG5_126768
Schistosoma mansoni ap endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Leishmania mexicana P-type ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trichomonas vaginalis cation-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma congolense vacuolar-type Ca2+-ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Mycobacterium tuberculosis Probable dihydroorotate dehydrogenase PyrD Get druggable targets OG5_127289 All targets in OG5_127289
Candida albicans similar to S. cerevisiae APN2 (YBL019W) DNA repair apurinic/apyrimidinic endonuclease Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania braziliensis vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trichomonas vaginalis plasma membrane calcium-transporting ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Trypanosoma congolense vacuolar-type Ca2+-ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Schistosoma mansoni tar DNA-binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Giardia lamblia Endonuclease/Exonuclease/phosphatase Get druggable targets OG5_126768 All targets in OG5_126768
Candida albicans likely dihydroorotate oxidase similar to S. pombe ura3 (SPAC57A10.12c) and to S. cerevisiae URA1 (YKL216W) involved in pyrimidin Get druggable targets OG5_127289 All targets in OG5_127289
Wolbachia endosymbiont of Brugia malayi exonuclease III Get druggable targets OG5_126768 All targets in OG5_126768
Leishmania infantum vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei gambiense dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126645 All targets in OG5_126645
Toxoplasma gondii calcium-translocating P-type ATPase, PMCA-type protein Get druggable targets OG5_126645 All targets in OG5_126645
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania mexicana vacuolar-type Ca2 -ATPase, putative Get druggable targets OG5_126645 All targets in OG5_126645
Echinococcus multilocularis tar DNA binding protein Get druggable targets OG5_132461 All targets in OG5_132461
Plasmodium yoelii dihydroorotate dehydrogenase, putative Get druggable targets OG5_127289 All targets in OG5_127289

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily B, polypeptide 6 491 aa 395 aa 19.5 %
Brugia malayi Cytochrome P450 family protein cytochrome P450, family 1, subfamily A, polypeptide 2 516 aa 470 aa 26.2 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Leishmania major calcium motive p-type ATPase, putative plasma membrane Ca2+ ATPase 1103 aa 1004 aa 24.9 %
Leishmania major calcium motive p-type ATPase, putative plasma membrane Ca2+ ATPase 1101 aa 1004 aa 24.7 %
Influenza A virus Hypothetical protein Nonstructural protein 1   230 aa 202 aa 23.8 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells assessed as decrease in parasite load at 10 uM treated for 1 hr prior to infection measured after 48 hrs by Alamar blue assay ChEMBL. 24824551
Activity (functional) Antimalarial activity against Plasmodium falciparum at 1 nM after 48 hrs ChEMBL. 18644969
Activity (functional) Antiparasitic activity against Toxoplasma gondii PRU-Luc-GFP type 2 infected in CD1 mouse acute toxoplasmosis model assessed as decrease in parasite burden at 10 mg/kg, sc administered once daily for 8 days measured after 25 days post-infection by luciferase reporter gene based assay ChEMBL. 19635951
Activity (functional) Antiplasmodial activity against liver stage Plasmodium berghei infected in human HuH7 cells assessed as decrease in parasite load at 2 uM treated for 1 hr prior to infection measured after 48 hrs by Alamar blue assay ChEMBL. 24824551
Activity (functional) Antimicrobial activity against Neospora caninum up to 1 ug/ml ChEMBL. 17562801
Activity (functional) Antiparasitic activity against Toxoplasma gondii PRU-Luc-GFP type 2 infected in CD1 mouse acute toxoplasmosis model assessed as decrease in parasite-induced cyst formation in mouse brain at 10 mg/kg, sc administered once daily for 8 days measured after 25 days post-infection by luciferase reporter gene based assay ChEMBL. 19635951
Activity (functional) Antimicrobial activity against Echinococcus multilocularis metacestode assessed as increase in alkaline phosphatase activity at 40 uM within 4 days ChEMBL. 18625777
Activity (functional) Antimalarial activity against Plasmodium falciparum W2 harboring 2 copy number of pfmdr1 gene organism selected at 200 ng/ml compound concentration ChEMBL. 20350946
Activity (functional) Antimicrobial activity against mid-ring stage Plasmodium falciparum 3D7 infected in erythrocytes assessed as reduction in parasitemia at 500 nM after 8 hrs by Giemsa-staining based microscopy relative to control ChEMBL. 24900611
Activity (functional) Antimalarial activity against Plasmodium falciparum W2 harboring 2 copy number of pfmdr1 gene organism selected at 40 ng/ml compound concentration ChEMBL. 20350946
Activity (functional) Antiplasmodial activity against Plasmodium falciparum assessed as pyknotic phenotype after 24 hrs by Giemsa-staining method ChEMBL. 24900481
Activity (functional) Antimicrobial activity against Echinococcus multilocularis metacestode assessed as increase in alkaline phosphatase activity at 10 uM ChEMBL. 18625777
Activity (functional) = 0 Antimalarial activity reported in mice infected with Plasmodium berghei after peroral administration the dose of 8 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 0 Antimalarial activity reported in mice infected with Plasmodium berghei after peroral administration the dose of 32 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 0 Antimalarial activity reported in mice infected with Plasmodium berghei after subcutaneous administration the dose of 8 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 0 Antimalarial activity reported in mice infected with Plasmodium berghei after peroral administration the dose of 128 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 0.17 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.26 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.31 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 30 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.47 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.51 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.7 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 0.81 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.05 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 30 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.06 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.09 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 30 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.22 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at schizonts stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.28 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at late ring stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.33 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at late ring stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.51 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at trophozoites stages at 10 uM treated at 30 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 1.96 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at early ring stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 2.01 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at late ring stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 2.06 Antimalarial activity against tightly synchronized Plasmodium falciparum W2 assessed as parasite stage accumulation index at early ring stages at 10 uM treated at 6 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 2.52 Antimalarial activity against tightly synchronized Plasmodium falciparum K1 assessed as parasite stage accumulation index at late ring stages at 10 uM treated at 18 hrs post-invasion for continuous duration of 36 hrs by automated image mining based cytological profiling assay ChEMBL. 25137549
Activity (functional) = 3 Antimalarial activity reported in mice infected with Plasmodium berghei after subcutaneous administration the dose of 32 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 5 Antimalarial activity reported in mice infected with Plasmodium berghei after subcutaneous administration the dose of 128 mg/Kg/day ChEMBL. 12213073
Activity (functional) = 100 Compound was tested for antimalarial activity in human red blood cells infected by Plasmodium falciparum ChEMBL. 15163175
Activity (functional) Active 0 In vivo antimalarial activity of the compound against Plasmodium berghei in mice; Active from 40 mg/kg ChEMBL. 11527712
Activity (ADMET) = 0 % Cytotoxicity against human HEK293 cells at 2 uM after 72 hrs by Alamar blue assay ChEMBL. 19637893
Activity (functional) = 0.1 % Antiplasmodial activity against artemisinin-tolerant Plasmodium falciparum F32-Tanzania assessed as parasitaemia at 9 uM after 48 hrs by rhodamine 123 staining ChEMBL. 20160056
Activity (ADMET) = 9.1 % Induction of CYP3A4 in human hepatocytes at 10 uM after 72 hrs relative to vehicle-treated control ChEMBL. 22679214
Activity (ADMET) = 18 % Induction of CYP2B6 in human hepatocytes at 10 uM after 72 hrs relative to vehicle-treated control ChEMBL. 22679214
Activity (ADMET) = 26 % Induction of CYP3A4 mRNA expression in human hepatocytes at 10 uM after 72 hrs by RT-PCR analysis relative to vehicle-treated control ChEMBL. 22679214
Activity (functional) = 35.9 % Antimalarial activity as parasitaemia against Plasmodium berghei ANKA infected Swiss albino mice (Mus musculus) at 100 uM/kg intraperitoneal dose after 3 days ChEMBL. 11720540
Activity (functional) = 48.3 % Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as reduction of hemozoin formation at IC50 after 48 hrs relative to control ChEMBL. 19269069
Activity (functional) = 50 % Antiparasitic activity against Leishmania major promastigotes assessed as parasite killing at 750 nM ChEMBL. 17339374
Activity (functional) = 50 % Antiparasitic activity against Leishmania major amastigotes in macrophage assessed as parasite killing at 3 to 30 uM ChEMBL. 17339374
Activity (functional) = 50 % Antiparasitic activity against Leishmania infantum promastigotes assessed as parasite killing at 1.4 to 382.9 uM ChEMBL. 17339374
Activity (functional) = 90.9 % Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as inhibition of sorbitol-induced hemolysis at 5 nM after 15 min by spectrophotometry ChEMBL. 19269069
Activity (functional) = 98 % In vivo evaluation of the compound for antimalarial activity against P. berghei in percentage when administered orally in mice ChEMBL. 10212135
Activity (functional) = 98 % Antimalarial activity as reduced parasitaemia at day 3 against Plasmodium berghei infected MORO mice (Mus musculus) at 100 mg/kg peroral dose ChEMBL. 17485500
Activity (functional) = 98 % Antimalarial activity as reduced parasitaemia after 3 days against Plasmodium berghei infected NMRI mice (Mus musculus) at 100 mg/kg peroral dose ChEMBL. 19616946
Activity (functional) = 98 % Antimalarial activity against Plasmodium berghei infected in NMRI mice (Mus musculus) assessed as reduction in parasitaemia at 100 mg/kg, perorally administered 1 day post-infection measured 3 day post-infection ChEMBL. 20943385
Activity (functional) = 99.99 % Antimalarial activity as reduced parasitaemia at day 3 against Plasmodium berghei infected MORO mice (Mus musculus) at 100 mg/kg subcutaneous dose ChEMBL. 17485500
Activity (functional) = 100 % In vivo evaluation of the compound for antimalarial activity against P. berghei in percentage when administered subcutaneously in mice ChEMBL. 10212135
Activity (functional) = 2170 % Antimalarial activity against Plasmodium falciparum D6 by [3H]hypoxanthine uptake relative to gedunin ChEMBL. 9134742
Activity (functional) = 4000 % Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake relative to gedunin ChEMBL. 9134742
Activity (functional) = 10 nM Antiplasmodial activity against CQ-resistant Plasmodium falciparum FcB1 ChEMBL. 25593097
CC50 (functional) = 0.0000283 M In vitro concentration of compound required to reduced spleen cell viability to 50% in BALB/c mice ChEMBL. 15999998
CC50 > 10 uM NOVARTIS: Cytotoxicity against human hepatocellular carcinoma cell line (Huh7) ChEMBL. 18579783
CC50 (ADMET) > 10 uM Cytotoxicity against human HepG2 cells expressing CD81 assessed as cell viability after 72 hrs by CellTiter-glo assay ChEMBL. 25791675
CD50 (functional) = 7 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected subcutaneously dosed mouse ChEMBL. 17242150
CD50 (functional) = 75 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected orally dosed mouse ChEMBL. 17242150
CD90 (functional) = 23 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected subcutaneously dosed mouse ChEMBL. 17242150
CD90 (functional) > 100 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected orally dosed mouse ChEMBL. 17242150
EC50 (functional) = 0.0000000078 M Compound was tested for antimalarial activity in vitro against chloroquine sensitive FCR-3 strain of P. falciparum ChEMBL. 10447961
EC50 (functional) = 0.00000001 M In vitro antimalarial activity of the compound against P. falciparum ChEMBL. 11428929
EC50 (functional) = 0.00000001 M In vitro antimalarial activity of the compound was determined against P. falciparum FCR-3 ChEMBL. 13678413
EC50 (functional) = 0.00001 M in vitro cytotoxicity of the compound against mouse mammary tumor in cell culture. ChEMBL. 11428929
EC50 (functional) = 0.00001 M Cytotoxicity of the compound was determined against FM3A mouse mammary cells ChEMBL. 13678413
EC50 (ADMET) = 0.00001 M In vitro cytotoxicity against mouse mammary FM3A cells ChEMBL. 12036365
EC50 (functional) = 0.00001 M Compound was tested for cytotoxicity against FM3A mouse mammary cells . ChEMBL. 10447961
EC50 (functional) = 1.1 ng/ml Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 10075777
EC50 (functional) = 4 nM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-sensitive Plasmodium falciparum 3D7 in human erythrocytes by DAPI stain ChEMBL. 18993067
EC50 (functional) = 4 nM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum Dd2 in human erythrocytes by DAPI stain ChEMBL. 18993067
EC50 (functional) = 6 nM Antimalarial activity against erythrocytic stage of chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting ChEMBL. 23517371
EC50 (functional) = 7.8 nM Antimalarial activity in Plasmodium falciparum FCR-3 strain ChEMBL. 10966746
EC50 (functional) = 8 nM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum FCB in human erythrocytes by DAPI stain ChEMBL. 18993067
EC50 (functional) = 8.8 nM In vitro antimalarial activity of the compound against Plasmodium falciparum (NF54) in mice was determined ChEMBL. 14971910
EC50 (functional) = 10 nM Antiproliferative activity in Mouse mammary tumour FM3A ChEMBL. 10966746
EC50 (functional) = 10 nM Antimalarial activity Plasmodium falciparum 3D7 ChEMBL. 20610151
EC50 (functional) < 10 nM Antiplasmodial activity against Plasmodium falciparum 3D7 by [3H]hypoxanthine incorporation assay ChEMBL. 18454143
EC50 (functional) = 10 nM Antimalarial activity against Plasmodium falciparum NF54 ChEMBL. 22128829
EC50 (functional) = 13 nM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 106/1 in human erythrocytes by DAPI stain ChEMBL. 18993067
EC50 (functional) = 15 nM Antiplasmodial activity against NITD609-resistant Plasmodium falciparum Dd2 infected in human erythrocytes after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 23587422
EC50 (functional) = 48 nM Antimalarial activity as reduced parasitaemia after 72 hrs against chloroquine-resistant Plasmodium falciparum 7G8 in human erythrocytes by DAPI stain ChEMBL. 18993067
EC50 (functional) = 0.0011 ug ml-1 In vitro antimalarial activity of the compound was determined against K1 multidrug resistant Plasmodium falciparum ChEMBL. 12773043
EC50 (functional) = 0.0117 ug ml-1 Antimalarial activity against chloroquine resistant Plasmodium falciparum K1 by pLDH assay ChEMBL. 16854076
EC50 (functional) = 0.0179 ug ml-1 Antimalarial activity against chloroquine sensitive Plasmodium falciparum FCR3 by pLDH assay ChEMBL. 16854076
EC50 (functional) > 100 ug ml-1 Cytotoxicity against mouse L929 cells by MTT assay ChEMBL. 16854076
EC50 (functional) = 0.0078 uM In vitro antimalarial activity against Plasmodium falciparum using a chloroquine sensitive FCR-3 strain ChEMBL. 10411480
EC50 (functional) = 0.01 uM Compound was tested invitro Antimalarial activity against Plasmodium falciparum ChEMBL. 12723958
EC50 (functional) = 0.01 uM In vitro antimalarial activity against plasmodium falciparum ChEMBL. 12361400
EC50 (functional) = 0.01 uM Antimalarial activity tested in vitro against Plasmodium falciparum. ChEMBL. 11882006
EC50 (functional) = 0.01026 uM NOVARTIS: Inhibition of Plasmodium falciparum W2 (drug-resistant) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (functional) = 0.012 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as LDH activity after 48 hrs ChEMBL. 15588096
EC50 (functional) = 0.017 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as LDH activity after 48 hrs ChEMBL. 15588096
EC50 (functional) = 0.018 uM Antimalarial activity against Plasmodium falciparum W2 by automated image mining based cytological profiling assay ChEMBL. 25137549
EC50 (functional) = 0.043 uM NOVARTIS: Inhibition of Plasmodium falciparum 3D7 (drug-susceptible) proliferation in erythrocyte-based infection assay ChEMBL. 18579783
EC50 (ADMET) = 0.6 uM Induction of CYP2B6 in human hepatocytes after 72 hrs relative to vehicle-treated control ChEMBL. 22679214
EC50 (functional) = 0.8 uM Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC50 (functional) = 1.51 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-6 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC50 (functional) = 1.73 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-1 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC50 (functional) = 1.8 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii STL500-10A infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC50 (ADMET) = 4 uM Induction of CYP2A6 mRNA expression in human hepatocytes after 72 hrs by RT-PCR analysis relative to vehicle-treated control ChEMBL. 22679214
EC50 (ADMET) = 5.9 uM Induction of CYP3A4 in human hepatocytes after 72 hrs relative to vehicle-treated control ChEMBL. 22679214
EC50 (functional) = 10 uM Compound was tested invitro cytotoxicity against FM3A cell ChEMBL. 12723958
EC50 (ADMET) = 10 uM Effective concentration against mouse mammary FM3A cells ChEMBL. 12361400
EC50 (functional) = 10 uM In vitro cytotoxicity in mouse mammary tumor FM3A cells ChEMBL. 10411480
EC50 (functional) = 10 uM Mammalian cell cytotoxicity assessed against mouse mammary tumor FM3A cells ChEMBL. 11882006
EC50 (ADMET) = 30 uM Activation of human PXR expressed in human LS174T cells ChEMBL. 22679214
EC90 (functional) = 1.24 uM Antiparasitic activity against Toxoplasma gondii ATCC 50839 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC90 (functional) = 4.77 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii STL500-10A infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC90 (functional) = 6.85 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-1 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
EC90 (functional) = 8.55 uM Antiparasitic activity against artemisinin-resistant Toxoplasma gondii KN200-6 infected in HFF cells after 72 hrs by beta-galactosidase reporter gene assay ChEMBL. 17698618
ED50 (functional) = 2 mg kg-1 In vivo effective dose for antimalarial activity of the compound administered intraperitoneally was determined ChEMBL. 13678413
ED50 (functional) = 3 mg kg-1 In vivo effective dose for antimalarial activity of the compound administered perorally was determined ChEMBL. 13678413
ED50 (functional) = 3 mg kg-1 In vivo antimalarial activity of the compound against Plasmodium berghei N on subcutaneous administration. ChEMBL. 9925735
ED50 (functional) = 5 mg kg-1 in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration ChEMBL. 11428929
ED50 (functional) = 5 mg kg-1 In vitro anti-malarial activity of the compound against P. berghei ChEMBL. 14592512
ED50 (functional) = 5.4 mg kg-1 Compound was tested invitro Antimalarial activity against Plasmodium berghei in infected mice administered intraperitoneally ChEMBL. 12723958
ED50 (functional) = 5.4 mg kg-1 In vivo 50% effective dose tested against Plasmodium berghei NK 65 infected mice, after intraperitoneal administration ChEMBL. 11882006
ED50 (functional) = 8.42 mg kg-1 Antimalarial activity against Plasmodium berghei ANKA infected po dosed mouse ChEMBL. 18341274
ED50 (functional) = 8.42 mg kg-1 Antimalarial activity against Plasmodium berghei ANKA infected po dosed mouse ChEMBL. 18341274
ED50 (functional) = 13 mg kg-1 in vivo antimalarial activity of the compound against P. berghei infected mice on oral administration ChEMBL. 11428929
ED50 (functional) = 13 mg kg-1 In vivo 50% effective dose tested against Plasmodium berghei NK 65 infected mice, after oral administration. ChEMBL. 11882006
ED50 (functional) = 32 mg kg-1 Compound was tested invitro Antimalarial activity against Plasmodium berghei in infected mice administered per orally ChEMBL. 12723958
ED50 (functional) = 607 mg kg-1 In vitro antimalarial activity against drug resistant strain (KBG 173) of P. berghei ChEMBL. 1501229
ED50 (functional) = 0.9500000000000002 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-sensitive Plasmodium berghei N after subcutaneous administration ChEMBL. 12773055
ED50 (functional) = 5 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-sensitive Plasmodium berghei N after oral administration ChEMBL. 12773055
ED50 (functional) = 5.8 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-resistant Plasmodium yoelii species. NS after subcutaneous administration ChEMBL. 12773055
ED50 (functional) = 5 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected subcutaneously dosed mouse ChEMBL. 17242150
ED50 (functional) = 16 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected orally dosed mouse ChEMBL. 17242150
ED50 (functional) = 0.7 ng ml-1 In vitro antimalarial activity against chloroquine-resistant K1 strain of Plasmodium falciparum ChEMBL. 12383020
ED50 (functional) = 2.9 ng ml-1 In vitro antimalarial activity against chloroquine-sensitive 3D7 strain of Plasmodium falciparum ChEMBL. 12383020
ED50 (functional) < 3.4 ng ml-1 In vitro antimalarial activity against chloroquine resistant (Smith) isolates of Plasmodium falciparum at dose 160 mg/kg in mice ChEMBL. 3906128
ED50 (functional) = 0.4 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake ChEMBL. 7528786
ED50 (functional) = 0.5 ng/ml Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum W2 infected type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8254346
ED50 (functional) = 0.6 ng/ml Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8254346
ED50 (functional) = 1.1 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake ChEMBL. 7528786
ED50 (functional) > 70900 nM Cytotoxicity against human KB cells after 72 hrs by SRB assay ChEMBL. 9917283
ED50 (functional) = 0.5 ug ml-1 Antimalarial activity after 24 hrs against Plasmodium falciparum W2 infected in type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8229016
ED50 (functional) = 0.6 ug ml-1 Antimalarial activity after 24 hrs against Plasmodium falciparum D6 infected type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8229016
ED50 (ADMET) > 20 ug ml-1 Cytotoxicity against human KB cells after 72 hrs ChEMBL. 11421741
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 16933872
ED50 (functional) = 3 uM kg-1 The effective dose (in vivo) to inhibit the 50% of Plasmodium berghei(N) when administered subcutaneously, four different doses(1,3,10 and 30 mg/kg) each day to five mice per dose regimen. ChEMBL. 9526568
ED50 (functional) = 8.5 uM kg-1 The effective dose (in vivo) to inhibit the 50% of Plasmodium berghei(N) when administered orally, four different doses(1,3,10 and 30 mg/kg) each day to five mice per dose regimen. ChEMBL. 9526568
ED50 (functional) = 17.7 uM kg-1 In vivo antimalarial activity against mice infected with Plasmodium berghei ChEMBL. 12036365
ED50 (functional) = 17.7 uM kg-1 Compound was tested for antimalarial activity against mouse malaria parasite P. berghei invivo and the samples were administrated intraperitoneally. ChEMBL. 10447961
ED90 (functional) = 2.3 Blood schizonticidal activity against P. berghei N strain ChEMBL. 3279208
ED90 (functional) = 4.8 Blood schizonticidal activity against P. berghei PYR strain ChEMBL. 3279208
ED90 (functional) = 6.2 Blood schizonticidal activity against P. berghei MEN strain ChEMBL. 3279208
ED90 (functional) = 7.5 Blood schizonticidal activity against P. berghei ORA strain ChEMBL. 3279208
ED90 (functional) = 8.2 Blood schizonticidal activity against P. berghei B strain ChEMBL. 3279208
ED90 (functional) = 10 Blood schizonticidal activity against P. berghei NS strain ChEMBL. 3279208
ED90 (functional) = 12 Blood schizonticidal activity against P. berghei P strain ChEMBL. 3279208
ED90 (functional) = 17 Blood schizonticidal activity against P. berghei 1100 strain ChEMBL. 3279208
ED90 (functional) = 24 Blood schizonticidal activity against P. berghei QS strain ChEMBL. 3279208
ED90 (functional) = 31 Blood schizonticidal activity against P. berghei N/HAL strain ChEMBL. 3279208
ED90 (functional) = 49 Blood schizonticidal activity against P. berghei ART strain ChEMBL. 3279208
ED90 (functional) = 90 Blood schizonticidal activity against P. berghei NPN strain ChEMBL. 3279208
ED90 (functional) = 630 Blood schizonticidal activity against P. berghei RC strain ChEMBL. 3279208
ED90 (functional) = 3.3 mg kg-1 In vivo effective dose for antimalarial activity of the compound administered intraperitoneally was determined ChEMBL. 13678413
ED90 (functional) = 8 mg kg-1 In vivo effective dose for antimalarial activity of the compound administered perorally was determined ChEMBL. 13678413
ED90 (functional) = 8.5 mg kg-1 In vivo antimalarial activity of the compound against Plasmodium berghei N on subcutaneous administration. ChEMBL. 9925735
ED90 (functional) = 13 mg kg-1 Compound was tested invitro Antimalarial activity against Plasmodium berghei in infected mice administered intraperitoneally ChEMBL. 12723958
ED90 (functional) = 32 mg kg-1 in vivo antimalarial activity of the compound against P. berghei infected mice on intraperitoneal administration ChEMBL. 11428929
ED90 (functional) = 32 mg kg-1 In vivo 90% effective dose tested against Plasmodium berghei NK 65 infected mice, after intraperitoneal administration ChEMBL. 11882006
ED90 (functional) = 89 mg kg-1 in vivo antimalarial activity of the compound against P. berghei infected mice on oral administration ChEMBL. 11428929
ED90 (functional) = 89 mg kg-1 Compound was tested invitro Antimalarial activity against Plasmodium berghei in infected mice administered per orally ChEMBL. 12723958
ED90 (functional) = 89 mg kg-1 In vivo 90% effective dose tested against Plasmodium berghei NK 65 infected mice, after oral administration. ChEMBL. 11882006
ED90 (functional) = 2.5 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-sensitive Plasmodium berghei N after subcutaneous administration ChEMBL. 12773055
ED90 (functional) = 10 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-resistant Plasmodium yoelii species. NS after subcutaneous administration ChEMBL. 12773055
ED90 (functional) = 14 mg kg-1 5day-1 In vivo antimalarial activity in mice against chloroquine-sensitive Plasmodium berghei N after oral administration ChEMBL. 12773055
ED90 (functional) = 23 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected subcutaneously dosed mouse ChEMBL. 17242150
ED90 (functional) = 27 mg/kg/day Antimalarial activity against Plasmodium yoelii nigeriensis infected orally dosed mouse ChEMBL. 17242150
ED90 (functional) = 9.2 uM kg-1 The effective dose (in vivo) to inhibit the 90% of Plasmodium berghei(N) when administered subcutaneously ChEMBL. 9526568
ED90 (functional) = 46 uM kg-1 In vivo Antimalarial activity against mice infected with Plasmodium berghei ChEMBL. 12036365
ED90 (functional) = 46 uM kg-1 Compound was tested for antimalarial activity against mouse malaria parasite P. berghei in vivo and the samples were administrated intraperitoneally. ChEMBL. 10447961
FC (ADMET) = 1.8 Activation of CAR (unknown origin) expressed in HEK293 cells at 10 uM ChEMBL. 22679214
FC (functional) = 2.2 Antimalarial activity against Plasmodium falciparum W2 assessed as level of pfmdr1 mRNA expression organism selected on 40 ng/ml of compound by quantitative real-time RT-PCR with respect to wild type ChEMBL. 20350946
FIC50 (functional) = 1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 3:1 ratio of compound to deoxyartemisinin ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of deoxyartemisinin ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 1:1 ratio of compound to carbaOZ277 ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of carbaOZ277 ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 1:3 ratio of compound to carbaOZ277 ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 3:1 ratio of compound to carbaOZ277 ChEMBL. 20028825
FIC50 (functional) = 1.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 1:1 ratio of compound to deoxyartemisinin ChEMBL. 20028825
FIC50 (functional) = 1.2 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence 1:3 ratio of compound to deoxyartemisinin ChEMBL. 20028825
FIC50 (functional) = 1.2 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.3 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.3 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.3 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.4 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.4 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-carboxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.8 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-hydroxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.9 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 1.9 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.1 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.2 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.3 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:3 ratio of compound to 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.3 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.5 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-hydroxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.6 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-oxo-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.8 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 3:1 ratio of compound to 4-amino-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 2.8 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 4-hydroxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
FIC50 (functional) = 4 Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay in presence of 1:1 ratio of compound to 4-hydroxy-2,2,6,6,-tetramethyl-1-piperidinyloxy ChEMBL. 20028825
GI (functional) Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage assessed as growth inhibition at 75 nM after 10 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 22686608
GI (functional) Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 trophozoite stage assessed as growth inhibition at 150 nM after 10 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 22686608
GI (functional) Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ring stage assessed as growth inhibition at 150 nM after 10 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 22686608
GI (functional) Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 trophozoite stage assessed as growth inhibition at 75 nM after 10 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 22686608
GI (functional) = 23 % Antitumor activity against human IMR32 cells at 50 uM after 48 hrs by Sulforhodamine assay ChEMBL. 19913412
GI (functional) = 26 % Antitumor activity against human IGROV1 cells at 50 uM after 48 hrs by Sulforhodamine assay ChEMBL. 19913412
GI (functional) = 29 % Antitumor activity against human A549 cells at 50 uM after 48 hrs by Sulforhodamine assay ChEMBL. 19913412
GI (functional) = 31 % Antitumor activity against human HCT15 cells at 50 uM after 48 hrs by Sulforhodamine assay ChEMBL. 19913412
GI (functional) = 35 % Antitumor activity against human SW620 cells at 50 uM after 48 hrs by Sulforhodamine assay ChEMBL. 19913412
GI (functional) = 36 % Cytotoxicity against human MCF7 cells assessed as growth inhibition at 50 uM by SRB assay ChEMBL. 24332623
Growth inhibition (functional) = 93 % In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 20 mg/kg/day ChEMBL. 10411480
Growth inhibition (functional) = 100 % In vivo antimalarial activity of the compound against Plasmodium berghei ( NK 65 strain ) in mice at 50 mg/kg/day ChEMBL. 10411480
Hemolysis (functional) = 4 % Compound was evaluated for the lysis of human erythrocytes at a concentration of 1 mM for 30 minutes at 37 degree C ChEMBL. 15027875
I 90 (functional) = 1 Blood schizonticidal activity against P. berghei N strain ChEMBL. 3279208
I 90 (functional) = 1.1 Blood schizonticidal activity against P. berghei PYR strain ChEMBL. 3279208
I 90 (functional) = 1.5 Blood schizonticidal activity against P. berghei MEN strain ChEMBL. 3279208
I 90 (functional) = 1.8 Blood schizonticidal activity against P. berghei ORA strain ChEMBL. 3279208
I 90 (functional) = 2 Blood schizonticidal activity against P. berghei B strain ChEMBL. 3279208
I 90 (functional) = 2.4 Blood schizonticidal activity against P. berghei NS strain ChEMBL. 3279208
I 90 (functional) = 2.9 Blood schizonticidal activity against P. berghei P strain ChEMBL. 3279208
I 90 (functional) = 4 Blood schizonticidal activity against P. berghei N/1100 strain ChEMBL. 3279208
I 90 (functional) = 10.4 Blood schizonticidal activity against P. berghei QS strain ChEMBL. 3279208
I 90 (functional) = 13.5 Blood schizonticidal activity against P. berghei N/HAL strain ChEMBL. 3279208
I 90 (functional) = 21.3 Blood schizonticidal activity against P. berghei ART strain ChEMBL. 3279208
I 90 (functional) = 21.4 Blood schizonticidal activity against P. berghei NPN strain ChEMBL. 3279208
I 90 (functional) = 150 Blood schizonticidal activity against P. berghei RC strain ChEMBL. 3279208
IC50 (binding) Inhibition of HDAC in human HeLa cell nuclear extracts after 15 mins by fluorescence assay ChEMBL. 19914074
IC50 (functional) Antileishmanial activity against Leishmania donovani ChEMBL. 19091562
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by alamar blue assay ChEMBL. 19914074
IC50 (functional) Antibacterial activity against Escherichia coli ATCC 35218 by modified CLSI/NCCLS method ChEMBL. 19879765
IC50 (functional) Antifungal activity against Candida albicans ATCC 90028 by modified CLSI/NCCLS method ChEMBL. 19879765
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes expressing luciferase ChEMBL. 12828469
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs ChEMBL. 12880315
IC50 (functional) Antileishmanial activity against Leishmania donovani ChEMBL. 15332848
IC50 (functional) Antiprotozoal activity against Trypanosoma brucei rhodesiense STIB900 ChEMBL. 16889962
IC50 (functional) Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream forms by microtiter plate based assay ChEMBL. 26063305
IC50 (functional) Antiplasmodial activity against Plasmodium berghei liver stage form transfected in human Huh-7 cells assessed as cell viability after 48 hrs by luciferase reporter gene assay ChEMBL. 23273038
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by alamar blue assay ChEMBL. 20669972
IC50 (functional) Antifungal activity against Cryptococcus neoformans ChEMBL. 17070063
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by almar blue assay ChEMBL. 18598080
IC50 (functional) Antitrypanosomal activity against Trypanosoma brucei brucei Lister 427 bloodstream form assessed as parasite LDH activity by three-fold serial dilution method ChEMBL. 23816880
IC50 (functional) Antifungal activity against Candida albicans ChEMBL. 17070063
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by Alamar blue assay ChEMBL. 17070063
IC50 (binding) Inhibition of human 5HT2c receptor expressed in CHO-K1 cells assessed as inhibition of 5HT-induced calcium influx measured up to 30 secs by aequorin luminescence assay ChEMBL. 24900481
IC50 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by alamar blue assay ChEMBL. 19105653
IC50 (functional) Antileishmanial activity against Leishmania donovani after 72 hrs by alamar blue assay ChEMBL. 16872140
IC50 (functional) Antileishmanial activity against Leishmania mexicana mexicana MHOM/BZ/84/BEL46 promastigotes assessed as parasite LDH activity by three-fold serial dilution method ChEMBL. 23816880
IC50 (functional) = 0.000000005 M In vitro antimalarial activity against P. falciparum ChEMBL. 9057849
IC50 (functional) = 0.0064 microM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by microplate assay ChEMBL. 19879671
IC50 (ADMET) > 354 microM Cytotoxicity against human KB cells after 72 hrs by alamar blue assay ChEMBL. 19957999
IC50 (functional) = 0.16 ng ml-1 Antimalarial activity against clone of human malaria, Plasmodium falciparum W-2 (Indochina clone) ChEMBL. 2202831
IC50 (functional) = 0.32 ng ml-1 In vitro antimalarial activity of the compound was determined against W-2 drug-resistant clone of P. falciparum. ChEMBL. 7861409
IC50 (functional) = 0.48 ng ml-1 In vitro antimalarial activity of the compound against the W-2 clone of P. falciparum ChEMBL. 8627612
IC50 (functional) = 0.56 ng ml-1 Antimalarial activity against clone of human malaria, Plasmodium falciparum D-6 (African clone) ChEMBL. 2202831
IC50 (functional) = 0.66 ng ml-1 In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) ChEMBL. 3669021
IC50 (functional) = 0.68 ng ml-1 Compound was evaluated in vitro for antimalarial activity against Indochina clone (W-2) of P. falciparum. ChEMBL. 1578492
IC50 (functional) = 0.86 ng ml-1 In vitro antimalarial activity of the compound was determined against D-6 drug-resistant clone of P. falciparum. ChEMBL. 7861409
IC50 (functional) = 0.95 ng ml-1 In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) ChEMBL. 8355254
IC50 (functional) = 0.97 ng ml-1 In vitro antimalarial activity of the compound against the D-6 clone of P. falciparum ChEMBL. 8627612
IC50 (functional) = 1 ng ml-1 In vitro antimalarial activity against Plasmodium falciparum W-2 (Indochina clone) relative to the activity of artemisinin ChEMBL. 8355254
IC50 (functional) = 1 ng ml-1 In vitro concentration causing 50% inhibition of uptake of [3H]- hypoxanthine by chloroquine resistant strains of P. falciparum. ChEMBL. 3280797
IC50 (functional) = 1 ng ml-1 50% reduction in parasite growth as indicated by the in vitro uptake of [3H]-hypoxanthine by P. falciparum ChEMBL. 12729658
IC50 (functional) = 1.015 ng ml-1 In vitro antimalarial activity against P. falciparum W-2 (Indo china clone) of human malaria. ChEMBL. 7877142
IC50 (functional) = 1.13 ng ml-1 In vitro concentration causing 50% inhibition of uptake of [3H]- hypoxanthine by chloroquine susceptible strains of P. falciparum ChEMBL. 3280797
IC50 (functional) = 1.15 ng ml-1 Inhibitory activity against Plasmodium falciparum W-2 clone ChEMBL. 10571157
IC50 (functional) = 1.21 ng ml-1 In vitro antimalarial activity was determined against w-2 clone culture of Plasmodium falciparum of Indochina origin resistant to chloroquine ChEMBL. 2329574
IC50 (functional) = 1.21 ng ml-1 In vitro antimalarial activity by the compound against Plasmodium falciparum was determined ChEMBL. 9871697
IC50 (functional) = 1.4 ng ml-1 Inhibition of Indochina(W-2) clone of Plasmodium falciparum parasites using [3H]-hypoxanthine incorporation as index of viability of the parasites. ChEMBL. 1619620
IC50 (functional) = 1.4 ng ml-1 In vitro antimalarial activity of the compound against the D-6 clone of P. falciparum, pLDH using Markler parasite LDH screening ChEMBL. 8627612
IC50 (functional) = 1.6 ng ml-1 In vitro concentration of the compound inhibiting chloroquine-resistant (K1) strain of Plasmodium falciparum ChEMBL. 16033274
IC50 (functional) = 1.89 ng ml-1 In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) ChEMBL. 8355254
IC50 (functional) = 2 ng ml-1 In vitro antimalarial activity against chloroquine-resistant K1 clone of Plasmodium falciparum ChEMBL. 15050646
IC50 (functional) = 2.138 ng ml-1 In vitro inhibitory concentration against P. falciparum clone CDC Indochina 3 (W-2). ChEMBL. 9135037
IC50 (functional) = 2.2 ng ml-1 In vitro antimalarial activity of the compound against the W-2 clone of P. falciparum, pLDH using Markler parasite LDH screening ChEMBL. 8627612
IC50 (functional) = 2.302 ng ml-1 In vitro antimalarial activity against P. falciparum D-6 (Sierra leone I clone) of human malaria. ChEMBL. 7877142
IC50 (functional) = 2.33 ng ml-1 In vitro antimalarial activity was determined against D-6 clone culture of Plasmodium falciparum of Sierra Leone origin resistant to mefloquine ChEMBL. 2329574
IC50 (functional) = 2.35 ng ml-1 In vitro antimalarial activity against the P. falciparum clone Sierra leone (D-6) ChEMBL. 2657065
IC50 (functional) = 2.6 ng ml-1 In vitro antimalarial activity against the P. falciparum clone Indochina (W-2) ChEMBL. 2657065
IC50 (functional) = 2.8 ng ml-1 In vitro concentration of the compound inhibiting chloroquine-sensitive (NF54) strain of Plasmodium falciparum ChEMBL. 16033274
IC50 (functional) = 2.93 ng ml-1 In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) ChEMBL. 3669021
IC50 (functional) = 2.94 ng ml-1 Compound was evaluated in vitro for antimalarial activity against Sierra Leone clone (D-6) of P. falciparum. ChEMBL. 1578492
IC50 (functional) = 2.97 ng ml-1 In vitro inhibitory activity against plasmodium falciparum (sierra leone clone) ChEMBL. 3279208
IC50 (functional) = 3 ng ml-1 In vitro inhibitory activity of the compoound against Chloroquine-sensitive P. falciparum (NF54), determined by measuring the incorporation of [3H]-hypoxanthine. ChEMBL. 7608890
IC50 (functional) = 3.9 ng ml-1 Inhibition of African Sierra Leone(D-6) clone of Plasmodium falciparum parasites using [3H]-hypoxanthine incorporation as index of viability of the parasites. ChEMBL. 1619620
IC50 (functional) = 3.912 ng ml-1 In vitro inhibitory concentration against P. falciparum clone CDC Seirra Leone 1 (D-6). ChEMBL. 9135037
IC50 (functional) = 4.19 ng ml-1 Inhibitory activity against Plasmodium falciparum D-6 clone ChEMBL. 10571157
IC50 (functional) = 8 ng ml-1 In vitro antimalarial activity against W-2 Indochina clone of Plasmodium falciparum ChEMBL. 8176702
IC50 (functional) = 8 ng ml-1 In vitro antimalarial activity against D-6 African clone of Plasmodium falciparum ChEMBL. 8176702
IC50 (functional) = 8 ng ml-1 In vitro antimalarial activity of the compound against D-6 clone of P. falciparum. ChEMBL. 7861408
IC50 (functional) = 8 ng ml-1 In vitro antimalarial activity of the compound against W-2 clone of P. falciparum. ChEMBL. 7861408
IC50 (functional) = 10 ng ml-1 In vitro antimalarial activity against chloroquine-sensitive 3D7 clone of Plasmodium falciparum ChEMBL. 15050646
IC50 (functional) = 0.2 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 11575956
IC50 (functional) = 0.43 ng/ml Antiplasmodial activity against Plasmodium falciparum W2 after 48 hrs ChEMBL. 18922036
IC50 (functional) = 0.5 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 11374943
IC50 (functional) = 0.5 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 11575956
IC50 (functional) = 0.5 ng/ml Antimalarial activity against Plasmodium falciparum W2 by [3H]hypoxanthine uptake ChEMBL. 9134742
IC50 (functional) = 0.71 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 1294700
IC50 (functional) = 1 ng/ml Antimalarial activity against Plasmodium falciparum W2 in RPMI 1640 based medium with human plasma after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1 ng/ml Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 12762793
IC50 (functional) = 1 ng/ml Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 12828479
IC50 (functional) = 1 ng/ml Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 assessed as inhibition of [3H]hypoxanthine uptake by microculture radioisotope technique ChEMBL. 19627125
IC50 (functional) = 1 ng/ml Antimalarial activity as reduced parasitaemia against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 12350163
IC50 (functional) = 1 ng/ml Antimalarial activity as growth inhibition of Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 11473437
IC50 (functional) = 1.1 ng/ml Antimalarial activity against Plasmodium falciparum W2 in folic acid free and p-aminobenzoic acid free RPMI 1640 based medium with Albumax 1 after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.1 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum Indochina W2 after 24 to 60 hrs by [G-H3]hypoxanthine uptake ChEMBL. 8289064
IC50 (functional) = 1.1 ng/ml Antiplasmodial activity against Plasmodium falciparum D6 clone after 48 hrs ChEMBL. 18922036
IC50 (functional) = 1.2 ng/ml Antimalarial activity against Plasmodium falciparum W2 in folic acid free and p-aminobenzoic acid free RPMI 1640 based medium with human plasma after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.25 ng/ml Antimalarial activity against Plasmodium falciparum D6 in RPMI 1640 based medium with human plasma after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.4 ng/ml Antimalarial activity against Plasmodium falciparum W2 in RPMI 1640 based medium with Albumax 1 after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.6 ng/ml Antimalarial activity against Plasmodium falciparum D6 in folic acid free and p-aminobenzoic acid free RPMI 1640 based medium with Albumax 1 after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.6 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) ChEMBL. 19616946
IC50 (functional) = 1.7 ng/ml Antimalarial activity against Plasmodium falciparum D6 in RPMI 1640 based medium with Albumax 1 after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.7 ng/ml Antimalarial activity against Plasmodium falciparum D6 in folic acid free and p-aminobenzoic acid free RPMI 1640 based medium with human plasma after 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 17371812
IC50 (functional) = 1.7 ng/ml Antimalarial activity against Plasmodium falciparum W2 assessed as incorporation of [3H]hypoxanthine after 72 hrs ChEMBL. 17371812
IC50 (functional) = 1.8 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 17400457
IC50 (functional) = 1.8 ng/ml Antimalarial activity against Plasmodium falciparum W2 in human erythrocytes after 24 hrs by [3H]hypoxanthine uptake ChEMBL. 1800638
IC50 (functional) = 1.8 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 11374943
IC50 (functional) = 1.8 ng/ml Antimalarial activity against Plasmodium falciparum D6 by [3H]hypoxanthine uptake ChEMBL. 9134742
IC50 (functional) = 1.8 ng/ml Antiplasmodial activity against Plasmodium falciparum W2 ChEMBL. 15730255
IC50 (functional) = 2 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 ChEMBL. 10869210
IC50 (functional) = 2 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by [3H]hypoxanthine uptake ChEMBL. 11421741
IC50 (functional) = 2 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by [3H]hypoxanthine uptake ChEMBL. 11421741
IC50 (functional) = 2.1 ng/ml Antiplasmodial activity against Plasmodium falciparum W2 ChEMBL. 8759172
IC50 (functional) = 2.1 ng/ml Antimalarial activity against mefloquine-resistant Plasmodium falciparum D6 (Sierra Leone) after 24 to 60 hrs by [G-H3]hypoxanthine uptake ChEMBL. 8289064
IC50 (functional) = 2.2 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 as [3H]hypoxanthine uptake ChEMBL. 8786363
IC50 (functional) = 2.4 ng/ml Antimalarial activity against Plasmodium falciparum D6 assessed as incorporation of [3H]hypoxanthine after 72 hrs ChEMBL. 17371812
IC50 (functional) = 2.5 ng/ml Antiplasmodial activity against Plasmodium falciparum NF54 ChEMBL. 10978215
IC50 (functional) = 2.5 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 9249972
IC50 (functional) = 2.7 ng/ml Antimalarial activity against Plasmodium falciparum D6 in human erythrocytes after 24 hrs by [3H]hypoxanthine uptake ChEMBL. 1800638
IC50 (functional) = 2.7 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 9249972
IC50 (functional) = 2.8 ng/ml Antiplasmodial activity against Plasmodium falciparum D6 ChEMBL. 8759172
IC50 (functional) = 2.8 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium berghei NF54 infected mice (Mus musculus) ChEMBL. 19616946
IC50 (functional) = 3 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum NF54 ChEMBL. 15787461
IC50 (functional) = 3.1 ng/ml Antimicrobial activity against Plasmodium falciparum FCC1/HN ChEMBL. 16434191
IC50 (functional) < 3.4 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum CAMP by semiautomated micro dilution assay ChEMBL. 6387056
IC50 (functional) < 3.4 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum Smith by semiautomated micro dilution assay ChEMBL. 6387056
IC50 (functional) = 3.4 ng/ml Antimalarial activity against Plasmodium falciparum NF54 ChEMBL. 17485500
IC50 (functional) = 3.4 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 ChEMBL. 20943385
IC50 (functional) = 3.6 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 17400457
IC50 (functional) = 3.6 ng/ml Antiplasmodial activity against Plasmodium falciparum D6 ChEMBL. 15730255
IC50 (functional) = 3.8 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as LDH activity after 72 hrs by malstat reagent method ChEMBL. 19928902
IC50 (functional) = 3.8 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by LDH assay ChEMBL. 20550123
IC50 (functional) = 4 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method ChEMBL. 19914074
IC50 (functional) = 4.1 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 as [3H]hypoxanthine uptake ChEMBL. 8786363
IC50 (functional) = 4.1 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 1294700
IC50 (functional) = 4.3 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity ChEMBL. 18598080
IC50 (functional) = 4.4 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH reporter assay ChEMBL. 11678659
IC50 (functional) = 4.4 ng/ml Antimalarial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum W2 as LDH activity by Makler method ChEMBL. 11374943
IC50 (functional) = 4.4 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH activity ChEMBL. 18598080
IC50 (functional) = 4.51 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte after 48 h by SYBR-Green-1 assay ChEMBL. 20576433
IC50 (functional) = 4.51 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum RKL9 infected in human erythrocyte after 48 h by SYBR-Green-1 assay ChEMBL. 20576433
IC50 (functional) = 4.7 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 assessed as LDH activity after 72 hrs by malstat reagent method ChEMBL. 19928902
IC50 (functional) = 4.7 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay ChEMBL. 20550123
IC50 (functional) = 5 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH reporter assay ChEMBL. 11678659
IC50 (functional) = 5 ng/ml Antimalarial activity after 48 hrs against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity by Makler method ChEMBL. 11374943
IC50 (functional) = 6 ng/ml Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 12502314
IC50 (functional) = 6 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs by Malstat reagent method ChEMBL. 19914074
IC50 (functional) = 6 ng/ml Antimalarial activity against Plasmodium falciparum K1 infected in human erythrocytes after 72 hrs by lactate dehydrogenase assay ChEMBL. 23499502
IC50 (functional) = 6.3 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 12828469
IC50 (functional) = 6.3 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 15332848
IC50 (functional) = 6.3 ng/ml Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes by LDH reporter assay ChEMBL. 16872140
IC50 (functional) = 7 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 11720540
IC50 (functional) = 7 ng/ml Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 12502314
IC50 (functional) = 8 ng/ml Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by LDH assay ChEMBL. 20017491
IC50 (functional) = 8.5 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH assay ChEMBL. 15165136
IC50 (functional) = 8.5 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH reporter assay ChEMBL. 12880315
IC50 (functional) = 9 ng/ml Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 17084633
IC50 (functional) = 10 ng/ml Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 12828469
IC50 (functional) = 10 ng/ml Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 15332848
IC50 (functional) = 10 ng/ml Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 in erythrocytes by LDH reporter assay ChEMBL. 16872140
IC50 (functional) = 12 ng/ml Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 11720540
IC50 (functional) = 12.14 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 infected in human type A-positive red blood cells assessed as parasite growth inhibition after 72 hrs by lactate dehydrogenase assay ChEMBL. 26022082
IC50 (functional) = 13 ng/ml Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 72 hrs by LDH assay ChEMBL. 20017491
IC50 (functional) = 14.3 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH assay ChEMBL. 15165136
IC50 (functional) = 14.3 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH reporter assay ChEMBL. 12880315
IC50 (functional) = 16 ng/ml Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 by pLDH activity ChEMBL. 19105653
IC50 (functional) = 17 ng/ml Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum W2 by pLDH activity ChEMBL. 19105653
IC50 (functional) = 10000 ng/ml Antimalarial activity against Plasmodium falciparum NF54 by [3H]hypoxanthine incorporation assay ChEMBL. 20028825
IC50 (functional) > 20000 ng/ml Cytotoxicity against human KB cells ChEMBL. 9134742
IC50 (ADMET) > 20000 ng/ml Cytotoxicity against human KB cells ChEMBL. 8759172
IC50 (ADMET) > 20000 ng/ml Cytotoxicity against human KB cells ChEMBL. 1294700
IC50 (functional) = 1 nM Intrinsic equimolar activity against P. falciparum (W-2 Indochina clone) relative to the simultaneous QHS control ChEMBL. 3279208
IC50 (functional) = 1 nM Intrinsic equimolar activity against P. falciparum (D-6 Sierra Leone clone) relative to the simultaneous QHS control ChEMBL. 3279208
IC50 (functional) = 1.26 nM Antiplasmodial activity against Plasmodium falciparum Dd2 harboring CYTb-Qi mutant ChEMBL. 24914738
IC50 (functional) = 1.3 nM Antiplasmodial activity against Plasmodium falciparum 7G8 harboring mutations conferring drug-resistance by SYBR-green based assay ChEMBL. 25007124
IC50 (functional) = 2.2 nM Compound was evaluated in vivo for antimalarial activity against W-2 clone of Plasmodium falciparum ChEMBL. 1501229
IC50 (functional) = 2.8 nM Antimalarial activity against Plasmodium falciparum infected in human O+ erythrocytes after 48 hrs by HRP2-ELISA method ChEMBL. 20621497
IC50 (functional) = 2.8 nM In vitro inhibitory concentration of the compound against Plasmodium falciparum K1 strain (0.0008 ug/mL) ChEMBL. 15664819
IC50 (functional) = 2.8 nM Antimalarial activity against erythrocytic stage of chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 24721829
IC50 (functional) = 3.04 nM Compound was tested in vitro for antimalarial activity against chloroquine sensitive HB3 strain of P. falciparum ChEMBL. 10639291
IC50 (functional) = 3.6 nM Compound was tested in vitro for antimalarial activity against chloroquine sensitive K1 strain of P. falciparum ChEMBL. 10639291
IC50 (functional) = 4 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in type B+ human erythrocytes assessed as inhibition of parasitemia after 48 hrs by Giemsa staining ChEMBL. 19269069
IC50 (functional) = 4 nM Antiplasmodial activity against chloroquine/pyrimethamine-resistant Plasmodium falciparum K1 infected in human red blood cells assessed as [3H]-hypoxanthine incorporation incubated for 48 hrs prior to [3H]-hypoxanthine addition measured after 24 hrs by liquid scintillation counting analysis ChEMBL. 24268543
IC50 (functional) = 4.24 nM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum V1/S ChEMBL. 19435664
IC50 (functional) = 4.3 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum NF54 after 72 hrs by [3H]hypoxanthine incorporation assay ChEMBL. 23360309
IC50 (functional) = 4.3 nM Antimalarial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum NF54 after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 24721829
IC50 (functional) = 4.37 nM Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry ChEMBL. 25062007
IC50 (functional) = 4.5 nM Antiparasitic activity against chloroquine sensitive Plasmodium falciparum assessed as [3H]hypoxanthin incorporation ChEMBL. 18260613
IC50 (functional) = 4.7 nM Compound was evaluated in vivo for antimalarial activity againstD-6 clone of Plasmodium falciparum ChEMBL. 1501229
IC50 (functional) = 5 nM Concentration of the compound required to inhibit 50% growth of P. falciparum K1 strain (Thailand) was determined using infected erythrocyte assay ChEMBL. 8182707
IC50 (functional) = 5 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 ChEMBL. 17242150
IC50 (functional) = 5 nM Antimalarial activity against Plasmodium falciparum 3D7 assessed as parasite growth inhibition after 18 hrs by SYBR Green-1 staining-based fluorescence assay ChEMBL. 23819803
IC50 (functional) = 5.38 nM Antiplasmodial activity against atovaquone-resistant Plasmodium falciparum FCR3 ChEMBL. 19435664
IC50 (functional) = 5.4 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human RBC ChEMBL. 24900603
IC50 (functional) = 5.41 nM The compound was evaluated for the antimalarial activity against Plasmodium falciparum in vitro in the presence of 20 mM FeCl3 ChEMBL. 7608896
IC50 (functional) = 5.7 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 18268087
IC50 (functional) = 5.82 nM Antimalarial activity against Plasmodium falciparum in vitro ChEMBL. 7608896
IC50 (functional) = 5.91 nM Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of schizonts growth after 48 hrs ChEMBL. 21696970
IC50 (functional) = 5.92 nM Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of ring-stage parasite growth after 48 hrs ChEMBL. 21696970
IC50 (functional) = 6 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum F32 ChEMBL. 17242150
IC50 (functional) = 6 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum Nigerian ChEMBL. 17242150
IC50 (functional) = 6 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 cultured in human erythrocytes assessed as inhibition of parasite growth incubated for 48 hrs by YOYO-1 staining based flow cytometry ChEMBL. 26067904
IC50 (functional) = 6.245 nM Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes after 48 hrs ChEMBL. 21696970
IC50 (functional) = 6.4 nM Antimalarial activity against the K1ains of P. falciparum ChEMBL. 8893847
IC50 (functional) = 6.41 nM Inhibitory concentration against P. falciparum (W-2 Indochina clone) ChEMBL. 3279208
IC50 (functional) = 6.46 nM Antimalarial activity against chloroquine- and mefloquine-resistant Plasmodium falciparum W2-Mef infected in human O-positive erythrocytes assessed as inhibition of trophozoites growth after 48 hrs ChEMBL. 21696970
IC50 (functional) = 6.5 nM Antimalarial activity against CQ-resistant Plasmodium falciparum W2 assessed as parasite growth inhibition after 48 hrs by YOYO-1 dye based flow cytometry ChEMBL. 25817773
IC50 (functional) = 6.6 nM Antimalarial activity against chloroquine sensitive Plasmodium falciparum NF54 ChEMBL. 16640333
IC50 (functional) = 6.7 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 16789736
IC50 (functional) = 6.7 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 17439202
IC50 (functional) = 6.7 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 17887664
IC50 (functional) = 6.7 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 18330976
IC50 (functional) = 6.7 nM Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2 ChEMBL. 18774792
IC50 (functional) = 6.7 nM Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum W2 ChEMBL. 18550377
IC50 (functional) = 6.7 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 18637666
IC50 (functional) = 6.7 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 21265542
IC50 (functional) = 6.7 nM Antimalarial activity against CQ-resistant, MFQ-susceptible Plasmodium falciparum W2 clone Indochina 1 isolate assessed as inhibition of parasite proliferation by MSF assay ChEMBL. 24742203
IC50 (functional) = 7 nM Antimalarial activity against Plasmodium falciparum W2mef trophozoite form by hoechst 33342-thiazole orange stain based flow cytometry assay ChEMBL. 19666223
IC50 (functional) = 7 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by flow cytometry ChEMBL. 24424135
IC50 (functional) = 7.2 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as reduction in parasite replication incubated for 62 hrs ChEMBL. 22680914
IC50 (functional) = 7.3 nM In vitro antimalarial activity against P. falciparum malarial parasite clone W2 (Indochina) ChEMBL. 10737758
IC50 (functional) = 7.3 nM Evaluated for the antimalarial activity againstchloroquine-resistant W2 clones of Plasmodium falciparum. ChEMBL. 10893313
IC50 (functional) = 7.3 nM In vitro inhibitory activity against chloroquine resistant W2 Indochina clone of Plasmodium falciparum ChEMBL. 12139444
IC50 (functional) = 7.3 nM Antimalarial activity in Plasmodium falciparum Indochina W2 clone ChEMBL. 10966746
IC50 (functional) = 7.3 nM Antimalarial activity against the HB3 strains of P. falciparum ChEMBL. 8893847
IC50 (functional) = 7.3 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as inhibition of [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counting ChEMBL. 20476788
IC50 (functional) = 7.31 nM Antiplasmodial activity against Plasmodium falciparum W2 infected in human erythrocytes ChEMBL. 22414614
IC50 (functional) = 7.71 nM Antimicrobial activity against leupeptin resistant-Plasmodium falciparum HB3-leuR1 mutant infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay ChEMBL. 18443109
IC50 (functional) = 8 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcM29 ChEMBL. 17242150
IC50 (functional) = 8 nM Antimalarial activity against Plasmodium falciparum W2mef schizont form by hoechst 33342-thiazole orange stain based flow cytometry assay ChEMBL. 19666223
IC50 (functional) = 8 nM Antimalarial activity against Plasmodium falciparum FCB infected in human A-positive type erythrocytes after 72 hrs by SRB assay ChEMBL. 22023506
IC50 (functional) = 8.2 nM Antimalarial activity against chloroquine-resistant erythrocyte stage of Plasmodium falciparum W2 after 48 hrs ChEMBL. 24900781
IC50 (functional) = 8.36 nM Antimicrobial activity against wild type Plasmodium falciparum HB3 infected in erythrocytes assessed as growth inhibition after 72 hrs by SYBR Green I-based fluorescence assay ChEMBL. 18443109
IC50 (functional) = 8.4 nM In vitro antimalarial activity against Plasmodium falciparum. ChEMBL. 9622557
IC50 (functional) = 8.4 nM In vitro antimalarial activity against P. falciparum malarial parasite clone D6 (Sierra Leone). ChEMBL. 10737758
IC50 (functional) = 8.4 nM Evaluated for the antimalarial activity against chloroquine-sensitive D6 clones of Plasmodium falciparum. ChEMBL. 10893313
IC50 (functional) = 8.4 nM In vitro inhibitory activity against chloroquine susceptible African D6 clone of Plasmodium falciparum ChEMBL. 12139444
IC50 (functional) = 8.6 nM Antimalarial activity in Plasmodium falciparum African D6 clone ChEMBL. 10966746
IC50 (functional) = 8.9 nM Antimalarial activity against Plasmodium falciparum NF54 ChEMBL. 16527481
IC50 (functional) = 9 nM In vitro antimalarialactivity against chloroquine sensitive Plasmodium falciparum (NF 54) parasites ChEMBL. 12620083
IC50 (functional) = 9 nM Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 16789736
IC50 (functional) = 9 nM Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 17887664
IC50 (functional) = 9 nM Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 18330976
IC50 (functional) = 9 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 18774792
IC50 (functional) = 9 nM Antimalarial activity against chloroquine and pyrimethamine-sensitive Plasmodium falciparum D6 ChEMBL. 18550377
IC50 (functional) = 9 nM Antimalarial activity against chloroquine,mefloquine-sensitive Plasmodium falciparum D6 ChEMBL. 18637666
IC50 (functional) = 9 nM Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 21265542
IC50 (functional) = 9 nM In vitro antimalarial activity against Plasmodium falciparum sensitive clone (Ghana) ChEMBL. 15863331
IC50 (functional) = 9.2 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 18341274
IC50 (functional) = 9.2 nM In vitro antimalarial activity in chloroquine sensitive Plasmodium falciparum (NF54) ChEMBL. 9526568
IC50 (functional) = 9.2 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 18243702
IC50 (functional) = 9.2 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 18341274
IC50 (functional) = 9.2 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by liquid scintillation and luminescence counting ChEMBL. 20227283
IC50 (functional) = 9.3 nM In vitro antimalarial activity against chloroquine-sensitive P. falciparum (NF 54) ChEMBL. 9871509
IC50 (functional) = 9.4 nM Antimalarial activity against plasmodium berghei in mice ChEMBL. 12190305
IC50 (functional) = 9.5 nM Antiplasmodial activity against CQ-resistant Plasmodium falciparum W2 blood stage form after 48 hrs by FACSort cytometry ChEMBL. 23273038
IC50 (functional) = 9.54 nM Antimalarial activity against Plasmodium falciparum 3D7 infected human erythrocytes after 24 hrs by [3H]hypoxanthine uptake ChEMBL. 18845438
IC50 (functional) = 9.67 nM In vitro antimalarial activity against HB3 chloroquine sensitive strain of Plasmodium falciparum (HB3 strain) ChEMBL. 11141088
IC50 (functional) = 9.67 nM Growth inhibition of Plasmodium falciparum ring stage infected in RBC by DAPI growth assay using imaging techniques ChEMBL. 17116676
IC50 (functional) = 9.7 nM The compound was tested in vitro for the antimalarial activity against chloroquine-sensitive NF54 strain of Plasmodium falciparum ChEMBL. 10543871
IC50 (functional) = 9.7 nM Growth inhibition of Plasmodium falciparum HB3 ring stage infected in RBC after 72 hrs by DAPI fluorimetry-based assay ChEMBL. 17116676
IC50 (functional) = 9.71 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 ChEMBL. 19435664
IC50 (functional) = 9.9 nM Antimalarial activity against the chloroquine sensitive NF54 strain of Plasmodium falciparum ChEMBL. 9925735
IC50 (functional) = 9.9 nM In vitro antimalarial activity against chloroquine sensitive P. falciparum (NF54). ChEMBL. 9526569
IC50 (functional) = 9.9 nM Antiplasmodial activity against artemisinin-tolerant Plasmodium falciparum F32-Tanzania ChEMBL. 20160056
IC50 (functional) = 9.9 nM Antiplasmodial activity against artemisinin-tolerant Plasmodium falciparum F32-Tanzania after 1000 days ChEMBL. 20160056
IC50 (functional) = 10 nM In vitro evaluation of the compound for antimalarial activity against P. falciparum using chloroquine resistant K1 strain ChEMBL. 10212135
IC50 (functional) = 10 nM Inhibitory concentration required against Plasmodium berghei ChEMBL. 15163175
IC50 (functional) = 10 nM In vitro antimalarial activity against Plasmodium falciparum resistant clone W-2 strain ChEMBL. 15863331
IC50 (functional) = 10.11 nM Growth inhibition of Plasmodium falciparum assessed as [3H]hypoxanthine incorporation ChEMBL. 17116676
IC50 (functional) = 10.53 nM Inhibitory concentration against P. falciparum (D-6 Sierra leone clone) ChEMBL. 3279208
IC50 (functional) = 10.63 nM Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry ChEMBL. 24287561
IC50 (functional) = 10.78 nM Growth inhibition of Plasmodium falciparum ring stage infected in RBC by DAPI growth assay using plate reader ChEMBL. 17116676
IC50 (functional) = 10.78 nM Growth inhibition of Plasmodium falciparum 3D7 ring stage infected in RBC after 72 hrs by DAPI fluorimetry-based assay ChEMBL. 17116676
IC50 (functional) = 11 nM Antimalarial activity against Plasmodium falciparum W2mef assessed as DNA positive erythrocytes by hoechst 33342-thiazole orange stain based flow cytometry assay ChEMBL. 19666223
IC50 (functional) = 11.15 nM In vitro antimalarial activity against K1 chloroquine resistant strain of Plasmodium falciparum (K1 strain) ChEMBL. 11141088
IC50 (functional) = 11.23 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected type A+ human erythrocytes after 24 hrs by [G-3H]hypoxanthine uptake ChEMBL. 19251414
IC50 (functional) = 12 nM In vitro evaluation of the compound for antimalarial activity against P. falciparum using drug resistant NF54 strain ChEMBL. 10212135
IC50 (functional) = 12 nM Concentration of the compound required to inhibit 50% growth of P. falciparum W2 strain(indochina) was determined using infected erythrocyte assay ChEMBL. 8182707
IC50 (functional) = 12 nM Antimalarial activity against Plasmodium falciparum W2mef by hypoxanthine uptake assay ChEMBL. 19666223
IC50 (functional) = 12 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 synchronized ring stage parasites infected in erythrocytes assessed as reduction in parasitemia after 48 hrs by Giemsa staining ChEMBL. 19435664
IC50 (functional) = 12 nM Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs ChEMBL. 21644570
IC50 (functional) = 12.2 nM Antiplasmodial activity against Plasmodium falciparum FcM29 ChEMBL. 19015354
IC50 (functional) = 12.3 nM Compound was tested in vitro for antimalarial activity using [3H]-hypoxanthine as a radioligand against K1 strain of Plasmodium falciparum ChEMBL. 14971909
IC50 (functional) = 12.3 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 by [3H]hypoxanthine uptake ChEMBL. 19136263
IC50 (functional) = 12.35 nM Growth inhibition of Plasmodium falciparum Dd2 ring stage infected in RBC after 72 hrs by DAPI fluorimetry-based assay ChEMBL. 17116676
IC50 (functional) = 12.5 nM In vitro inhibitory concentration against the K-1 chloroquine-resistant strain of Plasmodium falciparum ChEMBL. 11855985
IC50 (functional) = 12.5 nM Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by malaria SYBR Green I-based fluorescence assay ChEMBL. 20429578
IC50 (functional) = 12.5 nM Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 4 hrs ChEMBL. 20979352
IC50 (functional) = 12.5 nM Antiplasmodial activity against Plasmodium falciparum F32 ChEMBL. 19015354
IC50 (functional) = 12.6 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 16978862
IC50 (functional) = 12.6 nM Antimalarial activity against Plasmodium falciparum 3D7 ChEMBL. 16978862
IC50 (functional) = 12.8 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by [3H]hypoxanthine incorporation assay ChEMBL. 19957999
IC50 (functional) = 13 nM Concentration of the compound required to inhibit 50% growth of P. falciparum D6 strain(african) was determined using infected erythrocyte assay ChEMBL. 8182707
IC50 (functional) = 13 nM Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone1 bearing P-type ATPase4 I398F and P990R mutations after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 13 nM Antiplasmodial activity against asexual blood stage chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite growth inhibition by image-based assay ChEMBL. 24813731
IC50 (functional) = 13.04 nM Antimalarial activity against Plasmodium falciparum TM91C235 ChEMBL. 16789736
IC50 (functional) = 13.04 nM Antimalarial activity against Plasmodium falciparum TM91C235 ChEMBL. 17887664
IC50 (functional) = 13.04 nM Antimalarial activity against multidrug resistant-Plasmodium falciparum TM91C235 ChEMBL. 18330976
IC50 (functional) = 13.04 nM Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 ChEMBL. 18774792
IC50 (functional) = 13.04 nM Antimalarial activity against multidrug-resistant Plasmodium falciparum TM91C235 ChEMBL. 18637666
IC50 (functional) = 13.04 nM Antimalarial activity against Plasmodium falciparum C235 ChEMBL. 21265542
IC50 (functional) = 13.04 nM Antimalarial activity against multi drug resistant Plasmodium falciparum TM91C235 after 72 hrs by MSF assay ChEMBL. 23815186
IC50 (functional) = 13.3 nM Antiplasmodial activity against Plasmodium falciparum W2 ChEMBL. 19015354
IC50 (functional) = 13.5 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by malaria SYBR Green I-based fluorescence assay ChEMBL. 20429578
IC50 (functional) = 13.5 nM Antiplasmodial activity against Plasmodium falciparum Dd2 ChEMBL. 19015354
IC50 (functional) = 14 nM Antimalarial activity against Plasmodium falciparum W2 infected in human erythrocytes assessed as decrease in parasitemia after 72 hrs ChEMBL. 21644570
IC50 (functional) = 14 nM Antimalarial activity against chloroquine-resistant ring stage Plasmodium falciparum W2 assessed as parasitemia after 48 hrs by flow cytometry ChEMBL. 25038484
IC50 (functional) = 14.1 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by FACS analysis ChEMBL. 24824551
IC50 (functional) = 14.5 nM Compound was tested in vitro for antimalarial activity using [3H]-hypoxanthine as a radioligand against HB3 strain of Plasmodium falciparum ChEMBL. 14971909
IC50 (functional) = 14.5 nM In vitro antimalarial activity of compound against chloroquine-resistant (W2-Indochina) strain of P. falciparum ChEMBL. 13678403
IC50 (functional) = 14.5 nM Antiplasmodial activity against chloroquine-sensitive and mefloquine-resistant Plasmodium falciparum D6 ChEMBL. 19435664
IC50 (functional) = 14.6 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283
IC50 (functional) = 15 nM Growth inhibition in chloroquine-resistant Plasmodium falciparum FcB1-Knobs+ during 0 to 6 hrs of erythrocytic plasmodium life cycle ChEMBL. 17242150
IC50 (functional) = 15 nM Antimalarial activity against Plasmodium falciparum Dd2 after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 15 nM Antimalarial activity against Plasmodium falciparum assessed as [35S]Met/Cys incorporation by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 15.14 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283
IC50 (functional) = 15.36 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and expressing parental ATP4 after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 16 nM Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone3 bearing P-type ATPase4 D1247Y mutations after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 16.25 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 17 nM In vitro antimalarial activity of compound against chloroquine-sensitive (D6-Sierra Leone) strain of P. falciparum ChEMBL. 13678403
IC50 (functional) = 17.16 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing wild type ATP4 after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 17.34 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 17.96 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using CAM promoter driven expressing ATP4 I398F/P990R mutant after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 18 nM Inhibitory activity against the intra-erythrocytic form of the Plasmodium falciparum strain Dd2 ChEMBL. 11212126
IC50 (functional) = 18 nM Anti-malarial activity against Plasmodium falciparum strain Dd2 ChEMBL. 12699750
IC50 (functional) = 18 nM Antimalarial activity against NITD609-resistant Plasmodium falciparum Dd2 Clone2 bearing P-type ATPase4 T418N and P990R mutations after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 18.1 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitemia after 48 hrs by flow cytometry analysis ChEMBL. 24936235
IC50 (functional) = 19.7 nM Antimalarial activity against Plasmodium falciparum 7G8 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 19.78 nM Antimalarial activity against Plasmodium falciparum Dd2 containing attB site inserted in parasite genome and using EF1-alpha promoter driven expressing ATP4 D1247Y mutant after 72 hrs by SYBR green based fluorescence assay ChEMBL. 20813948
IC50 (functional) = 20 nM Antimalarial activity against Plasmodium falciparum W2mef ring form by hoechst 33342-thiazole orange stain based flow cytometry assay ChEMBL. 19666223
IC50 (functional) = 20.5 nM Antimalarial activity against Plasmodium falciparum 7G8 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 20.6 nM Antimalarial activity against Plasmodium falciparum 7G8 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 20.7 nM Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 20.7 nM Antimalarial activity against Plasmodium falciparum 7G8 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 20.9 nM Antimalarial activity against Plasmodium falciparum 7G8 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 22.3 nM Antimalarial activity against Plasmodium falciparum 7G8 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 22.3 nM Antimalarial activity against Plasmodium falciparum 7G8 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 25.2 nM Antimalarial activity against Plasmodium falciparum 7G8 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 25.3 nM Antimalarial activity against Plasmodium falciparum 7G8 clone M4 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 25.4 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 ChEMBL. 21489789
IC50 (functional) = 25.5 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D10 ChEMBL. 21489789
IC50 (functional) = 28 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in African green monkey (Cercopithecus aethiops) (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs ChEMBL. 19833520
IC50 (functional) = 28 nM Antiplasmodial activity against Plasmodium falciparum 3D7 after 72 hrs by SYBR green assay ChEMBL. 18454143
IC50 (functional) = 32.9 nM Antiplasmodial activity against Plasmodium falciparum D6 infected in RBCs by parasitic LDH release assay ChEMBL. 19879765
IC50 (functional) = 34.3 nM Antimalarial activity against Plasmodium falciparum D10 clone 2 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 36.2 nM Antiplasmodial activity against Plasmodium falciparum 3D7 assessed as reduction in parasite viability by parasite lactate dehydrogenase assay ChEMBL. 26063305
IC50 (functional) = 36.8 nM Antimalarial activity against Plasmodium falciparum D10 clone M3 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 42.5 nM Antiplasmodial activity against Plasmodium falciparum W2 infected in RBCs by parasitic LDH release assay ChEMBL. 19879765
IC50 (functional) = 42.8 nM Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 42.8 nM Antimalarial activity against Plasmodium falciparum D10 clone 1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 45 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FCK by [3H]hypoxanthine uptake ChEMBL. 19329310
IC50 (functional) = 45.5 nM Antimalarial activity against Plasmodium falciparum 3D7 after 72 hrs by lactate dehydrogenase assay ChEMBL. 17482816
IC50 (functional) = 46 nM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in African green monkey (Cercopithecus aethiops) Vero cells assessed as parasite LDH activity after 72 hrs ChEMBL. 19833520
IC50 (functional) = 47 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum K1 assessed as inhibition of parasite growth ChEMBL. 25913864
IC50 (functional) = 47.6 nM Antimalarial activity against Plasmodium falciparum D10 clone 1 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 49.4 nM Antimalarial activity against Plasmodium falciparum 3D7 after 48 hrs by lactate dehydrogenase assay ChEMBL. 17482816
IC50 (functional) = 50 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 48 hrs by lactate dehydrogenase assay ChEMBL. 17482816
IC50 (functional) = 51.6 nM Antimalarial activity against Plasmodium falciparum D10 harboring pfATP6 263E mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 51.6 nM Antimalarial activity against Plasmodium falciparum D10 clone M1 harboring pfATP6 L263 mutant assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 55 nM In vitro antimalarial activity against FCR3 Plasmodium falciparum strain ChEMBL. 12467620
IC50 (functional) = 55 nM Antimalarial activity against chloroquine-resistant Plasmodium falciparum FcB1 after 72 hrs by lactate dehydrogenase assay ChEMBL. 17482816
IC50 (functional) = 55.8 nM Antimalarial activity against Plasmodium falciparum D10 clone M2 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 62.3 nM Antimalarial activity against Plasmodium falciparum D10 clone M1 assessed as inhibition of [3H]hypoxanthine incorporation ChEMBL. 20566762
IC50 (functional) = 91 nM Antiplamodial activity against chloroquine-resistant bloodstream forms of Plasmodium falciparum K1 infected in human A+ erythrocytes assessed as growth inhibition after 48 hrs by spectrophotometry ChEMBL. 25454267
IC50 (functional) > 10000 nM Antiplasmodial activity against liver stage of Plasmodium yoelii 17X NL sporozoites infected in human HepG2 cells expressing CD81 after 48 hrs by DAPI staining-based immunofluorescence analysis ChEMBL. 25791675
IC50 (functional) = 1 nM ml-1 In vitro antimalarial activity against Plasmodium falciparum D-6 (Sierra Leone clone) relative to the activity of artemisinin ChEMBL. 8355254
IC50 (functional) < 3.4 nM ml-1 Antimalarial activity was determined against cloroquine-susceptible strains of Plasmodium falciparum in vitro ChEMBL. 3302259
IC50 (functional) < 3.4 nM ml-1 Antimalarial activity was determined against cloroquine-resistant strains of Plasmodium falciparum in vitro ChEMBL. 3302259
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 assessed as uptake of [3H]-hypoxanthine by microculture radioisotope technique ChEMBL. 17845001
IC50 (functional) = 0.001 ug ml-1 50% anti-plasmodial activity against Plasmodium falciparum(strain K1) ChEMBL. 12086492
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 assessed as uptake of [3H]-hypoxanthine by microculture radioisotope technique ChEMBL. 17845001
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 16933872
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 15730240
IC50 (functional) = 0.001 ug ml-1 Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 as [3H]hypoxanthine uptake ChEMBL. 15217275
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against multi drug-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine uptake after 18 hrs by microculture radioisotope technique ChEMBL. 19663417
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 16441071
IC50 (functional) = 0.001 ug ml-1 Antimalarial activity against Plasmodium falciparum K1 in human erythrocytes after 48 hrs by [3H]hypoxanthine uptake ChEMBL. 12193010
IC50 (functional) = 0.0011 ug ml-1 Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 11520217
IC50 (functional) = 0.003 ug ml-1 50% anti-plasmodial activity against Plasmodium falciparum(strain NF54) ChEMBL. 12086492
IC50 (functional) = 0.004 ug ml-1 Antiplasmodial activity against Plasmodium falciparum NF54 ChEMBL. 17562801
IC50 (functional) = 0.0045 ug ml-1 Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs ChEMBL. 17765547
IC50 (functional) = 0.006 ug ml-1 Antimalarial activity against drug-sensitive Plasmodium falciparum FCR3 infected human erythrocytes after 72 hrs ChEMBL. 19013823
IC50 (functional) = 0.006 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 ChEMBL. 16933872
IC50 (functional) = 0.0066 ug ml-1 Antimalarial activity against Plasmodium falciparum D6 after 72 hrs by alamar blue assay ChEMBL. 20669972
IC50 (functional) = 0.009 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH assay ChEMBL. 21172735
IC50 (functional) = 0.009 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 assessed as plasmodial LDH activity ChEMBL. 22483965
IC50 (functional) = 0.0091 ug ml-1 Antimalarial activity against Plasmodium falciparum W2 after 72 hrs by alamar blue assay ChEMBL. 20669972
IC50 (functional) = 0.01 ug ml-1 Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition by lactate dehydrogenase assay ChEMBL. 24593048
IC50 (functional) = 0.013 ug ml-1 Antiplasmodial activity against erythrocytic stage of chloroquine-sensitive Plasmodium falciparum 3D7 assessed as parasite LDH activity by three-fold serial dilution method ChEMBL. 23816880
IC50 (functional) = 0.015 ug ml-1 Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH assay ChEMBL. 21172735
IC50 (functional) = 0.02 ug ml-1 Antiinfective activity against Plasmodium falciparum W2 in red blood cells ChEMBL. 17134906
IC50 (functional) = 0.042 ug ml-1 Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 by [3H]hypoxanthine uptake ChEMBL. 15921407
IC50 (functional) = 0.045 ug ml-1 Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis ChEMBL. 25766631
IC50 (functional) = 2 ug ml-1 Antifungal activity against Cryptococcus neoformans ATCC 90113 by modified NCCLS method ChEMBL. 16124777
IC50 (functional) = 2.3 ug ml-1 Antimicrobial activity against Toxoplasma gondii in normal human foreskin fibroblasts ChEMBL. 17562801
IC50 (functional) = 6 ug ml-1 Antitrypanosomal activity against Trypanosoma brucei rhodesiense trypomastigotes after 72 hrs ChEMBL. 19159277
IC50 (functional) = 7.5 ug ml-1 Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 17070063
IC50 (functional) = 7.5 ug ml-1 Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH release assay ChEMBL. 17976995
IC50 (functional) = 8 ug ml-1 Antifungal activity against Candida albicans ATCC 90028 by modified NCCLS method ChEMBL. 16124777
IC50 (functional) = 8 ug ml-1 Antileishmanial activity against Leishmania major amastigotes ChEMBL. 17562801
IC50 (functional) = 8 ug ml-1 Antileishmanial activity against Leishmania donovani promastigotes ChEMBL. 17562801
IC50 (functional) = 8.8 ug ml-1 Antileishmanial activity against Leishmania donovani MHOM-ET-67/L82 amastigotes by axenic assay ChEMBL. 17562801
IC50 (functional) = 14 ug ml-1 Antimalarial activity against Plasmodium falciparum D6 ChEMBL. 17070063
IC50 (functional) = 14 ug ml-1 Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH release assay ChEMBL. 17976995
IC50 (functional) = 15.2 ug ml-1 Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 ChEMBL. 17084633
IC50 (functional) = 25 ug ml-1 Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB 900 ChEMBL. 19159277
IC50 (functional) = 25 ug ml-1 Antitrypanosomal activity against Trypanosoma brucei rhodesiense STIB900 ChEMBL. 17562801
IC50 (functional) > 30 ug ml-1 Antitrypanosomal activity against Trypanosoma cruzi Tulahuen C4 ChEMBL. 17562801
IC50 (functional) = 36 ug ml-1 Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by alamar blue assay ChEMBL. 15165136
IC50 (ADMET) > 40 ug ml-1 Cytotoxicity against mouse L929 cells after 5 days by MTT assay ChEMBL. 18922036
IC50 (functional) = 0 uM Antimicrobial activity against Plasmodium falciparum ChEMBL. 20185316
IC50 (functional) = 0.00082 uM Antiplasmodium activity against chloroquine-resistant intraerythrocytic stage of Plasmodium falciparum Dd2 assessed as parasite growth inhibition after 72 hrs by SYBR Green I staining-based assay ChEMBL. 25650896
IC50 (functional) = 0.001 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH reporter assay ChEMBL. 18362073
IC50 (functional) = 0.002 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2/Indochina by [3H]hypoxanthine uptake ChEMBL. 12398531
IC50 (functional) = 0.003 uM Antimalarial activity against Plasmodium falciparum HB3 ChEMBL. 21644541
IC50 (functional) = 0.004 uM In vitro inhibition against Plasmodium falciparum; Range is 0.004-0.02 uM ChEMBL. 3290484
IC50 (functional) = 0.004 uM Antiprotozoal activity against chloroquine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 23795673
IC50 (functional) = 0.004 uM Antiplasmodial activity against Plasmodium falciparum K1 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis ChEMBL. 24974345
IC50 (functional) = 0.0041 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 23871911
IC50 (functional) = 0.0043 uM Antiparasitic activity against Plasmodium falciparum ChEMBL. 17922552
IC50 (functional) = 0.0045 uM Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 as LDH activity ChEMBL. 18595720
IC50 (functional) = 0.005 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FCB1-R/Colombia by [3H]hypoxanthine uptake ChEMBL. 12398531
IC50 (functional) = 0.005 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes assessed as reduction in parasitaemia after 48 hrs by FACS ChEMBL. 20945914
IC50 (functional) = 0.005 uM Antimalarial activity against Plasmodium falciparum NF54 ChEMBL. 21644541
IC50 (functional) = 0.005 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 19091562
IC50 (functional) = 0.006 uM Antitrypanosomal activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 17948982
IC50 (functional) = 0.006 uM Antimalarial activity against Plasmodium falciparum DD2 expressing Saccharomyces cerevisiae DHOD by [3H]hypoxanthine uptake ChEMBL. 19097788
IC50 (functional) = 0.006 uM Antiplasmodial activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 19606902
IC50 (functional) = 0.006 uM Antiprotozoal activity after 48 hrs against chloroquine-resistant Plasmodium falciparum K1 infected erythrocytes by [3H]hypoxanthine uptake ChEMBL. 19267462
IC50 (functional) = 0.006 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 ChEMBL. 18841956
IC50 (functional) = 0.006 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum K1 infected in human erythrocytes after 48 hrs assessed as [3H]hypoxanthine incorporation by liquid scintillation counting ChEMBL. 19928900
IC50 (functional) = 0.0061 uM Antimalarial activity against Plasmodium falciparum 3D7 infected in human erythrocytes after 48 hrs by flow-cytometry ChEMBL. 20349996
IC50 (functional) = 0.0063 uM Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 as LDH activity ChEMBL. 18595720
IC50 (functional) = 0.0064 uM Antiprotozoal activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 ChEMBL. 16889962
IC50 (functional) = 0.0064 uM Antiplasmodial activity against chloroquine and pyremethamine-resistant Plasmodium falciparum K1 after 48 hrs by microplate assay ChEMBL. 17544672
IC50 (functional) = 0.0064 uM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs ChEMBL. 18502136
IC50 (functional) = 0.0064 uM Antimalarial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs as [3H]hypoxanthine uptake ChEMBL. 19395265
IC50 (functional) = 0.0064 uM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 assessed as [3H]hypoxanthine incorporation after 48 hrs by liquid scintillation counter ChEMBL. 22136906
IC50 (functional) = 0.0064 uM Antiplasmodial activity against chloroquine and pyrimethamine resistant Plasmodium falciparum K1 infected in human red blood cells assessed as reduction in parasite viability after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 25746816
IC50 (functional) = 0.0064 uM Antiprotozoal activity against chloroquine- and pyrimethamine-resistant Plasmodium falciparum K1 after 48 hrs by [3H]-hypoxanthine incorporation assay ChEMBL. 23880082
IC50 (functional) = 0.0064 uM Antiplasmodial activity against Plasmodium falciparum K1 infected in human blood by [3H]hypoxanthine incorporation assay ChEMBL. 20709557
IC50 (functional) = 0.0065 uM Antimalarial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR green-based assay ChEMBL. 25650255
IC50 (functional) = 0.0065 uM Antiplasmodial activity against multidrug-resistant Plasmodium falciparum K1 by SYBR Green-based method ChEMBL. 25599834
IC50 (functional) = 0.007 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum FcM29-Cameroon in presence of [3H]hypoxanthine after 48 hrs ChEMBL. 17904365
IC50 (functional) = 0.007 uM Antiplasmodial activity against chloroquine-resistant ring stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green 1-based fluorescence assay ChEMBL. 24326280
IC50 (functional) = 0.007 uM Antimalarial activity against chloroquine/mefloquine-resistant Plasmodium falciparum Dd2 incubated for 72 hrs by SYBR green I-based fluorescence assay ChEMBL. 26042470
IC50 (functional) = 0.007 uM Antiplasmodial activity against Plasmodium falciparum NF54 by SYBR Green-based method ChEMBL. 25599834
IC50 (functional) = 0.007 uM Antimalarial activity against drug-sensitive Plasmodium falciparum NF54 by SYBR green-based assay ChEMBL. 25650255
IC50 (functional) = 0.0073 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in human erythrocytes after 48 hrs by flow-cytometry ChEMBL. 20349996
IC50 (functional) = 0.008 uM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 16509575
IC50 (functional) = 0.008 uM Antimalarial activity against mefloquine-resistant Plasmodium falciparum W2 after 48 hrs by LDH assay ChEMBL. 21644541
IC50 (functional) = 0.00876 uM Antiplasmodial activity against chloroquine-resistant blood-stage Plasmodium falciparum W2 after 48 hrs by flow cytometric analysis ChEMBL. 22683112
IC50 (functional) = 0.009 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 by pLDH assay ChEMBL. 17125261
IC50 (functional) = 0.009 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs by LDH reporter assay ChEMBL. 18362073
IC50 (functional) = 0.009 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 after 72 hrs by lactate dehydrogenase assay ChEMBL. 25115700
IC50 (functional) = 0.009 uM Antiplasmodial activity against Plasmodium falciparum 3D7 infected in erythrocytes assessed as [3H]hypoxanthine incorporation after 24 hrs by microbeta scintillation counting analysis ChEMBL. 24974345
IC50 (functional) = 0.01 uM In vitro antimalarial activity against D2 strain of Plasmodium falciparum ChEMBL. 15027875
IC50 (functional) = 0.01 uM Antimalarial activity against Plasmodium falciparum DD2 by [3H]hypoxanthine uptake ChEMBL. 19097788
IC50 (functional) = 0.01 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected in red blood cells after 72 hrs by parasitic LDH assay ChEMBL. 24900509
IC50 (functional) = 0.011 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 infected in RBC assessed as plasmodial LDH activity after 72 hrs ChEMBL. 23218718
IC50 (functional) = 0.011 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by SYBR Green I staining ChEMBL. 23205265
IC50 (functional) = 0.012 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocytes after 96 hrs by luciferase based delayed death assay ChEMBL. 23205265
IC50 (functional) = 0.013 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D10 by pLDH assay ChEMBL. 17125261
IC50 (functional) = 0.013 uM Antimalarial activity against chloroquine /mefloquine/pyrimethamine-resistant Plasmodium falciparum C235 by malaria SYBR green 1-based fluorescence (MSF) assay ChEMBL. 25488841
IC50 (functional) = 0.014 uM In vitro antimalarial activity against ring stage of chloroquine-resistant Plasmodium falciparum W2 cultured in medium containing 10% human serum assessed as inhibition of parasite growth after 48 hrs by YOYO-1 dye based flow cytometry ChEMBL. 23434528
IC50 (functional) = 0.015 uM In vitro inhibition of Plasmodium falciparum growth was determined by using incorporated [3H]- hypoxanthine ChEMBL. 15006377
IC50 (functional) = 0.015 uM Antimalarial activity against Plasmodium falciparum W2 assessed as parasite LDH activity ChEMBL. 18248990
IC50 (functional) = 0.015 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum W2 in erythrocytes after 72 hrs by LDH activity ChEMBL. 19231182
IC50 (functional) = 0.015 uM Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 by Malstat LDH activity ChEMBL. 19574054
IC50 (functional) = 0.015 uM Antiplasmodial activity against erythrocytic stage of chloroquine-resistant Plasmodium falciparum IndoChina W2 infected in human A positive RBC after 48 hrs by [3H]hypoxanthine incorporation assay ChEMBL. 24900723
IC50 (functional) = 0.02 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 infected in RBC assessed as parasite LDH activity after 72 hrs ChEMBL. 22530813
IC50 (functional) = 0.02 uM Antiplasmodial activity against Plasmodium falciparum Dd2 assessed as inhibition of [3H]hypoxanthine incorporation incubated for 24 hrs prior to [3H]hypoxanthine addition measured after 24 hrs by beta scintillation counting ChEMBL. 24900481
IC50 (functional) = 0.021 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 after 72 hrs by DAPI staining method ChEMBL. 19637893
IC50 (functional) = 0.021 uM Antimalarial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by DAPI staining method ChEMBL. 19637893
IC50 (functional) = 0.021 uM Antiplasmodial activity against chloroquine-susceptible Plasmodium falciparum 3D7 after 72 hrs by fluorescence assay ChEMBL. 20462236
IC50 (functional) = 0.021 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum Dd2 after 72 hrs by fluorescence assay ChEMBL. 20462236
IC50 (functional) = 0.021 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 assessed as growth inhibition after 72 hrs by DAPI staining ChEMBL. 22686608
IC50 (functional) = 0.025 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 by LDH release assay ChEMBL. 19910192
IC50 (functional) = 0.025 uM Antimalarial activity against Plasmodium falciparum W2 assessed as plasmodial LDH activity after 72 hrs ChEMBL. 21530018
IC50 (functional) = 0.03 uM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 after 48 hrs ChEMBL. 16124784
IC50 (functional) = 0.03 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 by LDH release assay ChEMBL. 19910192
IC50 (functional) = 0.03 uM Antimalarial activity against Plasmodium falciparum D6 assessed as plasmodial LDH activity after 72 hrs ChEMBL. 21530018
IC50 (functional) = 0.035 uM Antimalarial activity against Plasmodium falciparum D6 assessed as parasite LDH activity ChEMBL. 18248990
IC50 (functional) = 0.035 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum D6 in erythrocytes after 72 hrs by LDH activity ChEMBL. 19231182
IC50 (functional) = 0.035 uM Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 by Malstat LDH activity ChEMBL. 19574054
IC50 (functional) = 0.04 uM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 after 48 hrs ChEMBL. 16124784
IC50 (functional) = 0.049 uM Antiplasmodial activity against chloroquine-resistant blood stage Plasmodium falciparum Dd2 after 72 hrs by SYBR Green I-based fluorescence assay ChEMBL. 24530004
IC50 (functional) = 0.0683 uM Antimalarial activity against multidrug-resistant Plasmodium falciparum isolate 208432 infected in human erythrocytes after 48 hrs by flow-cytometry ChEMBL. 20349996
IC50 (functional) < 0.09 uM Antiplasmodial activity against Plasmodium falciparum D6 infected in human RBC assessed as parasite growth inhibition measured as LDH activity after 72 hrs by plate reader analysis ChEMBL. 26005918
IC50 (functional) = 0.159 uM Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte assessed as parasite viability after 48 hrs by [3H]hypoxanthine incorporation based liquid scintillation counting analysis ChEMBL. 25766631
IC50 (functional) = 0.2 uM Antiplasmodial activity against chloroquine and pyrimethamine-resistant Plasmodium falciparum K1 infected mice (Mus musculus) macrophage by reporter dye assay ChEMBL. 17698622
IC50 (functional) = 0.25 uM Antifungal activity against Cryptococcus neoformans ATCC 90113 by modified CLSI/NCCLS method ChEMBL. 19879765
IC50 (functional) = 0.64 uM Antiparasitic activity against Toxoplasma gondii 2F infected in HFF cells assessed as beta galactosidase activity after 5 days ChEMBL. 20373807
IC50 (ADMET) = 8.4 uM Inhibition of CYP2B6 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysis ChEMBL. 22679214
IC50 (functional) = 9.9 uM Antimalarial activity after 72 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected in erythrocytes by LDH assay ChEMBL. 19084416
IC50 (binding) > 10 uM Inhibition of Plasmodium falciparum DHOD ChEMBL. 19097788
IC50 (binding) > 10 uM Inhibition of Saccharomyces cerevisiae DHOD ChEMBL. 19097788
IC50 (functional) > 10 uM Antimalarial activity against liver stage of Plasmodium berghei infected in human Huh7 cells after 48 hrs by luciferase assay ChEMBL. 24900781
IC50 (ADMET) = 12.1 uM Inhibition of recombinant CYP2B6 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 10 mins by LC-MS analysis ChEMBL. 22679214
IC50 (functional) = 12.9 uM Anticancer activity against human SK-MEL-2 cells by sulforhodamine B assay ChEMBL. 19819696
IC50 (functional) = 13.4 uM Growth inhibition of Trypanosoma cruzi epimastigotes after 72 hrs by Alamar blue assay ChEMBL. 17339374
IC50 (functional) = 14.3 uM Anticancer activity against human SKOV3 cells by sulforhodamine B assay ChEMBL. 19819696
IC50 (functional) = 15.2 uM Anticancer activity against human A549 cells by sulforhodamine B assay ChEMBL. 19819696
IC50 (functional) = 15.9 uM Antimalarial activity after 72 hrs against chloroquine-resistant Plasmodium falciparum W2 infected erythrocytes by LDH assay ChEMBL. 19084416
IC50 (functional) = 16.2 uM Anticancer activity against human XF498 cells by sulforhodamine B assay ChEMBL. 19819696
IC50 (functional) = 17.2 uM Anticancer activity against human HCT15 cells by sulforhodamine B assay ChEMBL. 19819696
IC50 (functional) > 20 uM Cytotoxicity against human A549 cells assessed as inhibition of cell proliferation after 72 hrs by SRB assay ChEMBL. 26318055
IC50 (functional) = 20.4 uM Growth inhibition of Trypanosoma brucei rhodesiense trypomastigotes after 72 hrs by Alamar blue assay ChEMBL. 17339374
IC50 (functional) = 30.4 uM Antiplasmodial activity against Plasmodium falciparum 3D7 infected in human RBC assessed as reduction in parasitemia after 48 hrs by fluorescence assay ChEMBL. 25076059
IC50 (functional) = 30.8 uM Growth inhibition of Leishmania donovani promastigotes after 72 hrs by Alamar blue assay ChEMBL. 17339374
IC50 (functional) = 36.9 uM Cytotoxicity against human CCRF-CEM by XTT assay ChEMBL. 20527917
IC50 (functional) = 36.9 uM Cytotoxicity against human CCRF-CEM cells by resazurin assay ChEMBL. 24561670
IC50 (functional) = 36.9 uM Cytotoxicity against human CCRF-CEM cells by CCK-8 assay ChEMBL. 22884578
IC50 (functional) = 36.9 uM Cytotoxicity against human CCRF-CEM cells assessed as cell viability after 72 hrs by resazurin assay ChEMBL. 26260339
IC50 (functional) = 40.7 uM Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by alamar blue assay ChEMBL. 19879765
IC50 (ADMET) = 50 uM Inhibition of recombinant CYP3A4 (unknown origin) incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysis ChEMBL. 22679214
IC50 (ADMET) = 50 uM Inhibition of CYP3A4 in human liver microsomes incubated for 3 mins prior to NADPH addition measured after 3 mins by LC-MS analysis ChEMBL. 22679214
IC50 (functional) > 50 uM Inhibitory activity against human umbilical vein endothelial cells (HUVEC) was assayed using MTT colorimetric proliferation assay ChEMBL. 14552753
IC50 (functional) > 50 uM Cytotoxicity against human HL60 cells after 18 hrs by annexin-V labeling-based flow cytometry ChEMBL. 22985027
IC50 (functional) = 124 uM Antileishmanial activity of compound against leishmania donovani was determined in luciferase assay ChEMBL. 13678403
IC50 (functional) = 124 uM Antimicrobial activity against Leishmania donovani ChEMBL. 20185316
IC50 (functional) > 200 uM Cytotoxicity against human SKHEP1 cells after 72 hrs by formazan test ChEMBL. 23685181
IC50 (functional) = 493.38 uM Cytotoxicity against human HeLa cells measured at 48 hrs by MTT assay ChEMBL. 26099535
IC50 (functional) = 0.01 uM well-1 In vitro schizont maturation inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FJB D9 ChEMBL. 11527712
IC50 (functional) = 0.01 uM well-1 In vitro schizont maturation inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FSH 14 ChEMBL. 11527712
IC50 (functional) = 0.01 uM well-1 In vitro total parasite growth inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FSH 14 ChEMBL. 11527712
IC50 (functional) = 0.01 uM well-1 In vitro schizont maturation inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FJB D9 ChEMBL. 11527712
IC50 (functional) = 0.01 uM well-1 In vitro schizont maturation inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FSH 14 ChEMBL. 11527712
IC50 (functional) = 0.01 uM well-1 In vitro total parasite growth inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FSH 14 ChEMBL. 11527712
IC50 (functional) = 0.015 uM well-1 In vitro total parasite growth inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FJB D9 ChEMBL. 11527712
IC50 (functional) = 0.015 uM well-1 In vitro total parasite growth inhibition of the compound against chloroquine sensitive Plasmodium falciparum strain FJB D9 ChEMBL. 11527712
IC80 (functional) = 8.46 ng/ml Antimalarial activity against chloroquine-sensitive Plasmodium falciparum 3D7 infected in human erythrocyte after 48 h by SYBR-Green-1 assay ChEMBL. 20576433
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by alamar blue assay ChEMBL. 20669972
IC90 (functional) Antileishmanial activity against Leishmania donovani after 72 hrs by alamar blue assay ChEMBL. 16872140
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by alamar blue assay ChEMBL. 19914074
IC90 (functional) Antileishmanial activity against Leishmania donovani ChEMBL. 15332848
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by Alamar blue assay ChEMBL. 17070063
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes expressing luciferase ChEMBL. 12828469
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs ChEMBL. 12880315
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 48 hrs by alamar blue assay ChEMBL. 19105653
IC90 (functional) Antileishmanial activity against Leishmania donovani promastigotes after 72 hrs by almar blue assay ChEMBL. 18598080
IC90 (functional) = 11.5 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 16789736
IC90 (functional) = 11.5 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 17887664
IC90 (functional) = 11.5 nM Antimalarial activity against Plasmodium falciparum W2 ChEMBL. 18330976
IC90 (functional) = 11.5 nM Antimalarial activity against chloroquine-resistant, mefloquine-susceptible Plasmodium falciparum W2 ChEMBL. </