Detailed information for compound 1778821

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 350.823 | Formula: C15H15ClN4O2S
  • H donors: 0 H acceptors: 3 LogP: 2.49 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COC(=O)c1cc2nc(n(c2cc1Cl)C)SCCn1ccnc1
  • InChi: 1S/C15H15ClN4O2S/c1-19-13-8-11(16)10(14(21)22-2)7-12(13)18-15(19)23-6-5-20-4-3-17-9-20/h3-4,7-9H,5-6H2,1-2H3
  • InChiKey: IYNUBVXXXNYGOX-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.00720782 0.00777807 0.0115563
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00952524 0.0142402 0.0142402
Echinococcus multilocularis nuclear receptor co repressor related (ncor) 0.351159 0.966893 0.966893
Echinococcus multilocularis beta tubulin 0.103939 0.277516 0.277516
Echinococcus multilocularis tyrosine protein kinase Srms 0.00804893 0.0101235 0.0101235
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Plasmodium vivax histone deacetylase, putative 0.201659 0.55001 0.816373
Loa Loa (eye worm) TK/ABL protein kinase 0.0243516 0.0555837 0.0825835
Echinococcus granulosus tyrosine protein kinase Src42A 0.00755562 0.00874789 0.00874789
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.0985904 0.2626 0.390158
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Plasmodium vivax plasmepsin IV, putative 0.0241269 0.0549571 0.0776106
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00720782 0.00777807 0.0115563
Loa Loa (eye worm) histone deacetylase 11 0.126011 0.339062 0.503762
Schistosoma mansoni amine GPCR 0.105475 0.281798 0.418681
Onchocerca volvulus 0.105475 0.281798 0.693931
Brugia malayi histone deacetylase 11 0.126011 0.339062 0.503762
Plasmodium vivax histone deacetylase 2, putative 0.201659 0.55001 0.816373
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis c src tyrosine kinase 0.00807521 0.0101968 0.0101968
Schistosoma mansoni neuropeptide receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis SWI:SNF matrix associated 0.00547619 0.00294937 0.00294937
Echinococcus granulosus integrin alpha ps 0.00678746 0.00660587 0.00660587
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.105475 0.281798 0.281798
Echinococcus granulosus histone deacetylase 6 0.208867 0.570109 0.570109
Loa Loa (eye worm) integrin alpha pat-2 0.0247467 0.0566856 0.0842207
Echinococcus granulosus tm gpcr rhodopsin 0.187788 0.511329 0.511329
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.105475 0.281798 0.281798
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0220028 0.0490342 0.068772
Brugia malayi histone deacetylase 3 (HD3) 0.245787 0.67306 1
Trypanosoma cruzi histone deacetylase 1, putative 0.245787 0.67306 1
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Echinococcus granulosus tachykinin peptides receptor 99D 0.105475 0.281798 0.281798
Leishmania major histone deacetylase, putative 0.201659 0.55001 0.81504
Trypanosoma cruzi histone deacetylase, putative 0.201659 0.55001 0.81504
Schistosoma mansoni growth hormone secretagogue receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.105475 0.281798 0.418681
Schistosoma mansoni histone deacetylase 0.245787 0.67306 1
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.0241269 0.0549571 0.0816526
Echinococcus granulosus dro:myosuppressin receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.105475 0.281798 0.418681
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.00720782 0.00777807 0.00777807
Plasmodium falciparum plasmepsin V 0.00570411 0.00358495 0.000948462
Echinococcus granulosus Tubulin beta 2C chain 0.103939 0.277516 0.277516
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.00720782 0.00777807 0.00777807
Trypanosoma brucei beta tubulin 0.103939 0.277516 0.405448
Trichomonas vaginalis hypothetical protein 0.0220028 0.0490342 0.068772
Brugia malayi aspartic protease BmAsp-1, identical 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00952524 0.0142402 0.0142402
Echinococcus multilocularis integrin alpha ps 0.00678746 0.00660587 0.00660587
Plasmodium falciparum plasmepsin I 0.0241269 0.0549571 0.0776106
Echinococcus granulosus histone deacetylase 7 0.201659 0.55001 0.55001
Plasmodium falciparum plasmepsin III 0.00570411 0.00358495 0.000948462
Leishmania major histone deacetylase, putative 0.201659 0.55001 0.81504
Trichomonas vaginalis tubulin gamma chain, putative 0.103939 0.277516 0.409732
Brugia malayi Dopamine receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi Integrin beta pat-3 precursor 0.130148 0.350599 0.520903
Echinococcus granulosus integrin beta 2 0.0963883 0.256459 0.256459
Schistosoma mansoni brca1-associated protein (brap2) 0.00720782 0.00777807 0.0115563
Schistosoma mansoni peptide (allatostatin)-like receptor 0.150047 0.406089 0.603347
Onchocerca volvulus 0.0065989 0.00608009 0.0149723
Plasmodium falciparum histone deacetylase 2 0.201659 0.55001 0.816373
Giardia lamblia Histone deacetylase 0.245787 0.67306 1
Leishmania major histone deacetylase, putative 0.245787 0.67306 1
Echinococcus multilocularis Tubulin beta 2C chain 0.103939 0.277516 0.277516
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0359448 0.0879118 0.120451
Brugia malayi Calcitonin receptor-like protein seb-1 0.00517099 0.00209832 0.00311758
Schistosoma mansoni cathepsin D (A01 family) 0.0711366 0.186045 0.276416
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0241269 0.0549571 0.0776106
Plasmodium falciparum histone deacetylase 1 0.245787 0.67306 1
Echinococcus granulosus hypothetical protein 0.105475 0.281798 0.281798
Echinococcus granulosus histone deacetylase 8 0.103069 0.275089 0.275089
Echinococcus granulosus EGFP:Bcl2 fusion protein 0.0564101 0.14498 0.14498
Brugia malayi Tachykinin-like peptides receptor 99D 0.123842 0.333016 0.494778
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.00720782 0.00777807 0.0115563
Giardia lamblia Beta tubulin 0.103939 0.277516 0.405448
Brugia malayi Furin-like cysteine rich region family protein 0.00724714 0.00788772 0.0117192
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.105475 0.281798 0.693931
Echinococcus multilocularis alpha 1A adrenergic receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0220028 0.0490342 0.068772
Giardia lamblia High cysteine membrane protein Group 2 0.038003 0.0936511 0.129077
Loa Loa (eye worm) TK protein kinase 0.00653504 0.00590199 0.00876889
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00720782 0.00777807 0.0115563
Toxoplasma gondii Zn-finger in ubiquitin-hydrolases domain-containing protein 0.00720782 0.00777807 0.00720581
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Onchocerca volvulus 0.00570411 0.00358495 0.00882798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus neuropeptide receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Brugia malayi Melatonin receptor type 1A 0.105475 0.281798 0.418681
Echinococcus granulosus serotonin receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis fmrfamide receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis g-protein coupled receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0634535 0.16462 0.16462
Schistosoma mansoni histone deacetylase 4 5 0.201659 0.55001 0.817177
Toxoplasma gondii beta-1 tubulin, putative 0.103939 0.277516 0.409732
Brugia malayi G protein-coupled receptor 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus granulosus neuropeptides capa receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis BRCA1-associated protein, putative 0.00720782 0.00777807 0.00720581
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.00720782 0.00777807 0.00777807
Echinococcus multilocularis anti dorsalizing morphogenetic protein 1a 0.0140568 0.0268766 0.0268766
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.00720782 0.00777807 0.00720581
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.00720782 0.00777807 0.00777807
Schistosoma mansoni furin-1 (S08 family) 0.0480645 0.121708 0.180827
Brugia malayi Histone deacetylase family protein 0.201659 0.55001 0.817177
Plasmodium vivax hypothetical protein, conserved 0.00720782 0.00777807 0.00720581
Schistosoma mansoni hypothetical protein 0.0055626 0.00319033 0.00474004
Echinococcus multilocularis tyrosine protein kinase Abl 0.0120269 0.0212163 0.0212163
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Loa Loa (eye worm) TYRA-2 protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) SWIB/MDM2 domain-containing protein 0.00547619 0.00294937 0.00438203
Plasmodium falciparum plasmepsin VII 0.00570411 0.00358495 0.000948462
Echinococcus granulosus SWI:SNF matrix associated 0.00547619 0.00294937 0.00294937
Brugia malayi Apoptosis regulator proteins, Bcl-2 family protein 0.0055626 0.00319033 0.00474004
Brugia malayi Kelch motif family protein 0.0197902 0.0428643 0.0636856
Schistosoma mansoni apoptosis regulator bax 0.0055626 0.00319033 0.00474004
Onchocerca volvulus 0.00570411 0.00358495 0.00882798
Loa Loa (eye worm) SH2 domain-containing protein 0.00610559 0.00470448 0.00698968
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Loa Loa (eye worm) hypothetical protein 0.0446169 0.112094 0.166543
Brugia malayi protein-tyrosine kinase 0.00804893 0.0101235 0.015041
Onchocerca volvulus 0.00547619 0.00294937 0.00726287
Schistosoma mansoni tyrosine kinase 0.00724714 0.00788772 0.0117192
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Loa Loa (eye worm) tubulin beta-1 chain 0.103939 0.277516 0.412319
Echinococcus granulosus allatostatin A receptor 0.150047 0.406089 0.406089
Echinococcus multilocularis tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Brugia malayi Dopamine receptor protein 1 0.105475 0.281798 0.418681
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Trichomonas vaginalis tubulin alpha chain, putative 0.103939 0.277516 0.409732
Plasmodium vivax aspartyl proteinase, putative 0.0241269 0.0549571 0.0776106
Loa Loa (eye worm) integrin beta-2 0.130148 0.350599 0.520903
Onchocerca volvulus 0.00617019 0.0048846 0.0120284
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00720782 0.00777807 0.00720581
Loa Loa (eye worm) hypothetical protein 0.103069 0.275089 0.408713
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00720782 0.00777807 0.00720581
Schistosoma mansoni tyrosine kinase 0.0228377 0.0513622 0.0763114
Onchocerca volvulus 0.105475 0.281798 0.693931
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0241269 0.0549571 0.0776106
Schistosoma mansoni opsin-like receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis histone deacetylase 6 0.201659 0.55001 0.55001
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.00517099 0.00209832 0.00311758
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis EGFP:Bcl2 fusion protein 0.0564101 0.14498 0.14498
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00952524 0.0142402 0.0142402
Trypanosoma cruzi beta tubulin, putative 0.103939 0.277516 0.405448
Echinococcus granulosus tyrosine protein kinase ABL1 0.0243516 0.0555837 0.0555837
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Plasmodium vivax aspartyl protease, putative 0.00570411 0.00358495 0.000948462
Echinococcus granulosus tyrosine protein kinase Lyn 0.00957599 0.0143817 0.0143817
Schistosoma mansoni histone deacetylase 1 2 3 0.103069 0.275089 0.408713
Brugia malayi SWIB/MDM2 domain containing protein 0.00547619 0.00294937 0.00438203
Echinococcus multilocularis neuroendocrine convertase 2 0.0700674 0.183063 0.183063
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis tubulin beta 1 chain 0.103939 0.277516 0.277516
Schistosoma mansoni hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis orexin receptor type 2 0.105475 0.281798 0.281798
Echinococcus granulosus somatostatin receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0241269 0.0549571 0.0816526
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.105475 0.281798 0.281798
Brugia malayi Tyrosine-protein kinase abl-1 0.0138009 0.0261631 0.0388718
Echinococcus granulosus neuropeptide receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0220028 0.0490342 0.068772
Schistosoma mansoni histone deacetylase hda2 0.103069 0.275089 0.408713
Plasmodium vivax histone deacetylase 1, putative 0.245787 0.67306 1
Echinococcus multilocularis sex peptide receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0634535 0.16462 0.24126
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Onchocerca volvulus 0.105475 0.281798 0.693931
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00952524 0.0142402 0.0142402
Plasmodium vivax aspartyl proteinase, putative 0.00570411 0.00358495 0.000948462
Echinococcus multilocularis SWI:SNF matrix associated 0.00547619 0.00294937 0.00294937
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.105475 0.281798 0.281798
Trypanosoma brucei beta tubulin 0.103939 0.277516 0.405448
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00755562 0.00874789 0.00874789
Loa Loa (eye worm) TK/EGFR protein kinase 0.00724714 0.00788772 0.0117192
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.245787 0.67306 1
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Entamoeba histolytica tubulin family protein 0.103939 0.277516 0.40712
Loa Loa (eye worm) G-protein coupled receptor 0.105475 0.281798 0.418681
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Brugia malayi Histone deacetylase 1 0.245787 0.67306 1
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) BRCA1-associated protein 2 containing protein 0.00720782 0.00777807 0.0115563
Schistosoma mansoni integrin beta subunit 0.076598 0.201274 0.299043
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00952524 0.0142402 0.0142402
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.00720782 0.00777807 0.00720581
Echinococcus granulosus ephrin type A receptor 4 A 0.0066635 0.00626021 0.00626021
Schistosoma mansoni neuropeptide F-like receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis integrin alpha 3 0.013014 0.0239686 0.0239686
Echinococcus multilocularis histone deacetylase 0.201659 0.55001 0.55001
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Schistosoma mansoni histone deacetylase 4 5 0.201659 0.55001 0.817177
Onchocerca volvulus 0.105475 0.281798 0.693931
Brugia malayi Serotonin receptor 0.151204 0.409315 0.60814
Trypanosoma brucei beta tubulin 0.103939 0.277516 0.405448
Brugia malayi AKH receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00720782 0.00777807 0.0115563
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0241269 0.0549571 0.0549571
Echinococcus multilocularis epidermal growth factor receptor 0.00724714 0.00788772 0.00788772
Trypanosoma brucei histone deacetylase 2 0.103069 0.275089 0.4018
Schistosoma mansoni hypothetical protein 0.0220028 0.0490342 0.0728526
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0241269 0.0549571 0.0549571
Loa Loa (eye worm) neuropeptide F receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) tubulin beta-4 chain 0.103939 0.277516 0.412319
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus multilocularis dnaJ subfamily B 0.231882 0.634287 0.634287
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.00720782 0.00777807 0.00720581
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi G protein-coupled receptor F59B2.13 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.10807 0.289035 0.429434
Echinococcus granulosus tyrosine protein kinase Blk 0.00804893 0.0101235 0.0101235
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus granulosus anti dorsalizing morphogenetic protein 1a 0.0140568 0.0268766 0.0268766
Toxoplasma gondii UBA/TS-N domain-containing protein 0.00720782 0.00777807 0.00720581
Echinococcus granulosus g protein coupled receptor 0.105475 0.281798 0.281798
Brugia malayi beta-tubulin, identical 0.103939 0.277516 0.412319
Echinococcus multilocularis tachykinin peptides receptor 99D 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis allatostatin A receptor 0.150047 0.406089 0.406089
Loa Loa (eye worm) histone deacetylase 1 0.245787 0.67306 1
Brugia malayi histone deacetylase 1 (HD1) 0.245787 0.67306 1
Loa Loa (eye worm) brahma associated protein 0.00547619 0.00294937 0.00438203
Plasmodium vivax tubulin beta chain, putative 0.103939 0.277516 0.409732
Loa Loa (eye worm) hypothetical protein 0.00570411 0.00358495 0.00532634
Loa Loa (eye worm) bone morphogenic protein 6 0.0140568 0.0268766 0.0399319
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Onchocerca volvulus 0.105475 0.281798 0.693931
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.00720782 0.00777807 0.00777807
Trichomonas vaginalis tubulin epsilon chain, putative 0.103939 0.277516 0.409732
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00720782 0.00777807 0.00720581
Echinococcus granulosus histone deacetylase 6 0.201659 0.55001 0.55001
Onchocerca volvulus 0.105475 0.281798 0.693931
Plasmodium vivax plasmepsin V, putative 0.00570411 0.00358495 0.000948462
Loa Loa (eye worm) hypothetical protein 0.00903674 0.012878 0.0191335
Echinococcus granulosus thyrotropin releasing hormone receptor 0.105475 0.281798 0.281798
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00804893 0.0101235 0.0101235
Echinococcus granulosus Bcl 2 ous antagonist:killer 0.0055626 0.00319033 0.00319033
Schistosoma mansoni biogenic amine (5HT) receptor 0.142036 0.38375 0.570157
Brugia malayi G-protein coupled receptor 0.105475 0.281798 0.418681
Plasmodium falciparum plasmepsin VI 0.0241269 0.0549571 0.0776106
Onchocerca volvulus 0.105475 0.281798 0.693931
Echinococcus granulosus tyrosine protein kinase Src42A 0.00952524 0.0142402 0.0142402
Echinococcus multilocularis Tubulin beta 2C chain 0.103939 0.277516 0.277516
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Toxoplasma gondii histone deacetylase HDAC2 0.245787 0.67306 1
Echinococcus multilocularis SWI:SNF matrix associated 0.00547619 0.00294937 0.00294937
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.245787 0.67306 1
Echinococcus multilocularis neuropeptide Y receptor 0.105475 0.281798 0.281798
Schistosoma mansoni myosin xvIII 0.105475 0.281798 0.418681
Echinococcus granulosus G protein coupled receptor 139 0.105475 0.281798 0.281798
Onchocerca volvulus 0.105475 0.281798 0.693931
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase 5, putative 0.00720782 0.00777807 0.00281204
Schistosoma mansoni biogenic amine receptor 0.105475 0.281798 0.418681
Brugia malayi gonadotropin-releasing hormone receptor 2 0.105475 0.281798 0.418681
Trichomonas vaginalis histone deacetylase 1, 2 ,3, putative 0.245787 0.67306 1
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.105475 0.281798 0.418681
Echinococcus multilocularis histone deacetylase 7 0.201659 0.55001 0.55001
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni hypothetical protein 0.00547619 0.00294937 0.00438203
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Trypanosoma brucei beta tubulin 0.103939 0.277516 0.405448
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis tubulin, beta 4A class IVa 0.103939 0.277516 0.277516
Echinococcus granulosus g-protein coupled receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis 0.0860675 0.22768 0.22768
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Trypanosoma cruzi histone deacetylase, putative 0.103069 0.275089 0.4018
Onchocerca volvulus Histone deacetylase 10 homolog 0.103069 0.275089 0.67741
Schistosoma mansoni histamine h1 receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) kelch domain-containing protein family protein 0.0197902 0.0428643 0.0636856
Loa Loa (eye worm) tubulin beta chain 0.103939 0.277516 0.412319
Echinococcus granulosus tyrosine kinase 0.00804893 0.0101235 0.0101235
Echinococcus multilocularis g protein coupled receptor 0.105475 0.281798 0.281798
Schistosoma mansoni tyrosine kinase 0.00807521 0.0101968 0.0151499
Echinococcus multilocularis neuropeptide FF receptor 2 0.123842 0.333016 0.333016
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Loa Loa (eye worm) hypothetical protein 0.0359448 0.0879118 0.130615
Loa Loa (eye worm) hypothetical protein 0.245787 0.67306 1
Brugia malayi putative neuropeptide receptor NPR1 0.105475 0.281798 0.418681
Echinococcus granulosus neuropeptide FF receptor 2 0.123842 0.333016 0.333016
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Brugia malayi aspartic protease BmAsp-2, identical 0.00570411 0.00358495 0.00532634
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Plasmodium falciparum plasmepsin II 0.0241269 0.0549571 0.0776106
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Trypanosoma brucei histone deacetylase 4 0.201659 0.55001 0.81504
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.105475 0.281798 0.281798
Toxoplasma gondii histone deacetylase HDAC5 0.103069 0.275089 0.406111
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Echinococcus multilocularis neuropeptide receptor 0.105475 0.281798 0.281798
Echinococcus granulosus tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Loa Loa (eye worm) hypothetical protein 0.00517099 0.00209832 0.00311758
Loa Loa (eye worm) TK/CSK protein kinase 0.00508501 0.00185858 0.00276138
Trichomonas vaginalis tubulin beta chain, putative 0.103939 0.277516 0.409732
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis integrin alpha ps 0.00678746 0.00660587 0.00660587
Schistosoma mansoni brg-1 associated factor 0.00547619 0.00294937 0.00438203
Echinococcus multilocularis Tubulin beta 2C chain 0.103939 0.277516 0.277516
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0241269 0.0549571 0.0816526
Brugia malayi Transforming growth factor beta like domain containing protein 0.0140568 0.0268766 0.0399319
Brugia malayi map kinase activated protein kinase protein 2 0.0228397 0.051368 0.07632
Trichomonas vaginalis brca1-associated protein, putative 0.00720782 0.00777807 0.00720581
Echinococcus granulosus tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0634535 0.16462 0.24126
Trypanosoma cruzi histone deacetylase, putative 0.201659 0.55001 0.81504
Leishmania major C-8 sterol isomerase-like protein 0.0359448 0.0879118 0.120451
Echinococcus multilocularis neuropeptide receptor A26 0.105475 0.281798 0.281798
Schistosoma mansoni cathepsin D (A01 family) 0.0711366 0.186045 0.276416
Echinococcus granulosus orexin receptor type 2 0.105475 0.281798 0.281798
Echinococcus granulosus histone deacetylase 3 0.245787 0.67306 0.67306
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis ephrin type A receptor 4 A 0.0066635 0.00626021 0.00626021
Toxoplasma gondii aspartyl protease 0.00570411 0.00358495 0.000948462
Brugia malayi celfurPC protein 0.0860675 0.22768 0.338275
Echinococcus multilocularis tyrosine protein kinase Blk 0.00804893 0.0101235 0.0101235
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.10807 0.289035 0.429434
Toxoplasma gondii beta-tubulin, putative 0.103939 0.277516 0.409732
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.00720782 0.00777807 0.00720581
Trypanosoma brucei C-8 sterol isomerase, putative 0.0359448 0.0879118 0.120451
Echinococcus granulosus integrin alpha 3 0.013014 0.0239686 0.0239686
Echinococcus granulosus neuropeptide Y receptor 0.105475 0.281798 0.281798
Schistosoma mansoni biogenic amine receptor 0.105475 0.281798 0.418681
Brugia malayi larval opioid receptor 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus multilocularis tyrosine protein kinase HCK 0.00653504 0.00590199 0.00590199
Echinococcus multilocularis Bcl 2 ous antagonist:killer 0.0055626 0.00319033 0.00319033
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.363032 1 1
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.105475 0.281798 0.418681
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus multilocularis neuropeptide receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) BEN-1 protein 0.103939 0.277516 0.412319
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Echinococcus granulosus tubulin beta 4A class IVa 0.103939 0.277516 0.277516
Echinococcus multilocularis g protein coupled receptor 0.105475 0.281798 0.281798
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.00570411 0.00358495 0.000948462
Loa Loa (eye worm) neuropeptide F receptor 0.105475 0.281798 0.418681
Plasmodium falciparum plasmepsin X 0.00570411 0.00358495 0.000948462
Echinococcus granulosus neuropeptide receptor A26 0.105475 0.281798 0.281798
Echinococcus granulosus tyrosine protein kinase HCK 0.00653504 0.00590199 0.00590199
Toxoplasma gondii aspartyl protease ASP3 0.00570411 0.00358495 0.000948462
Brugia malayi putative neuropeptide receptor 0.105475 0.281798 0.418681
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.105475 0.281798 0.418681
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni ephrin receptor 0.0066635 0.00626021 0.00930112
Brugia malayi brahma associated protein 60 kDa 0.00547619 0.00294937 0.00438203
Loa Loa (eye worm) follicle stimulating hormone receptor 0.105475 0.281798 0.418681
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Echinococcus granulosus c src tyrosine kinase 0.00807521 0.0101968 0.0101968
Loa Loa (eye worm) hypothetical protein 0.00617019 0.0048846 0.0072573
Echinococcus multilocularis neuropeptides capa receptor 0.105475 0.281798 0.281798
Echinococcus granulosus alpha 1A adrenergic receptor 0.105475 0.281798 0.281798
Echinococcus granulosus peptide allatostatin:somatostatin 0.105475 0.281798 0.281798
Schistosoma mansoni hypothetical protein 0.0055626 0.00319033 0.00474004
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) beta-tubulin 0.103939 0.277516 0.412319
Brugia malayi neuropeptide F receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) histone deacetylase 3 0.245787 0.67306 1
Echinococcus multilocularis neuropeptide s receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis G-protein coupled receptor, putative 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis fmrfamide receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis dro:myosuppressin receptor 0.105475 0.281798 0.281798
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Loa Loa (eye worm) proprotein convertase 2 0.0254505 0.0586481 0.0871364
Echinococcus granulosus Tubulin beta 2C chain 0.103939 0.277516 0.277516
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus tubulin beta 1 chain 0.103939 0.277516 0.277516
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi Eukaryotic aspartyl protease family protein 0.00570411 0.00358495 0.00532634
Brugia malayi Histone deacetylase family protein 0.201659 0.55001 0.817177
Loa Loa (eye worm) histone deacetylase 0.201659 0.55001 0.817177
Echinococcus granulosus tyrosine protein kinase Src64B 0.00952524 0.0142402 0.0142402
Plasmodium vivax aspartyl protease, putative 0.00570411 0.00358495 0.000948462
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus histone deacetylase 6 0.201659 0.55001 0.55001
Leishmania major histone deacetylase, putative 0.245787 0.67306 1
Plasmodium falciparum tubulin beta chain 0.103939 0.277516 0.409732
Schistosoma mansoni memapsin-2 (A01 family) 0.00570411 0.00358495 0.00532634
Echinococcus granulosus tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Brugia malayi hypothetical protein 0.0197902 0.0428643 0.0636856
Echinococcus granulosus tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.105475 0.281798 0.418681
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Plasmodium falciparum plasmepsin IX 0.00570411 0.00358495 0.000948462
Trypanosoma brucei histone deacetylase 1 0.245787 0.67306 1
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) G-protein coupled receptor 0.105475 0.281798 0.418681
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Echinococcus multilocularis serotonin receptor 0.114005 0.305585 0.305585
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.00720782 0.00777807 0.0115563
Brugia malayi Tubulin beta-1 chain 0.103939 0.277516 0.412319
Echinococcus granulosus epidermal growth factor receptor 0.00724714 0.00788772 0.00788772
Schistosoma mansoni alpha-1 adrenergic receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.105475 0.281798 0.418681
Loa Loa (eye worm) tubulin beta-2A chain 0.103939 0.277516 0.412319
Loa Loa (eye worm) melatonin receptor type 1A 0.105475 0.281798 0.418681
Schistosoma mansoni hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) TK/EPH protein kinase 0.00835511 0.0109773 0.0163096
Brugia malayi endoprotease bli-4 precursor 0.10807 0.289035 0.429434
Chlamydia trachomatis DNA topoisomerase I 0.00547619 0.00294937 0.5
Plasmodium falciparum plasmepsin IV 0.0241269 0.0549571 0.0776106
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Loa Loa (eye worm) hypothetical protein 0.150047 0.406089 0.603347
Onchocerca volvulus Neuropeptide F receptor homolog 0.105475 0.281798 0.693931
Loa Loa (eye worm) hypothetical protein 0.0132944 0.0247507 0.0367734
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.105475 0.281798 0.418681
Brugia malayi neuroendocrine convertase 1 precursor 0.0700674 0.183063 0.271986
Loa Loa (eye worm) hypothetical protein 0.0184573 0.0391474 0.0581632
Echinococcus granulosus BRCA1 associated protein 0.00720782 0.00777807 0.00777807
Giardia lamblia Beta tubulin 0.103939 0.277516 0.405448
Trypanosoma brucei histone deacetylase 3 0.201659 0.55001 0.81504
Toxoplasma gondii aspartyl protease ASP1 0.0241269 0.0549571 0.0776106
Schistosoma mansoni histone deacetylase hda2 0.208867 0.570109 0.84704
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00720782 0.00777807 0.00720581
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.105475 0.281798 0.281798
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00720782 0.00777807 0.0115563
Toxoplasma gondii beta tubulin 0.103939 0.277516 0.409732
Echinococcus granulosus histone deacetylase 0.201659 0.55001 0.55001
Echinococcus granulosus tm gpcr rhodopsin 0.105475 0.281798 0.281798
Loa Loa (eye worm) endoprotease bli-4 0.10807 0.289035 0.429434
Giardia lamblia Furin precursor putative serine protease 0.0220028 0.0490342 0.062013
Loa Loa (eye worm) hypothetical protein 0.00976048 0.0148962 0.022132
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Schistosoma mansoni amine GPCR 0.105475 0.281798 0.418681
Echinococcus granulosus tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Trypanosoma brucei histone deacetylase, putative 0.201659 0.55001 0.81504
Echinococcus granulosus fmrfamide receptor 0.105475 0.281798 0.281798
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00720782 0.00777807 0.00720581
Echinococcus multilocularis integrin beta 2 0.0963883 0.256459 0.256459
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Toxoplasma gondii histone deacetylase HDAC4 0.126011 0.339062 0.501578
Brugia malayi brahma associated protein 60 kDa 0.00547619 0.00294937 0.00438203
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Echinococcus granulosus dnaJ subfamily B 0.231882 0.634287 0.634287
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus g protein coupled receptor 0.105475 0.281798 0.281798
Schistosoma mansoni amine GPCR 0.105475 0.281798 0.418681
Schistosoma mansoni opsin-like receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis MAP kinase activated protein kinase 2 0.0228397 0.051368 0.051368
Brugia malayi neuropeptide F receptor 0.105475 0.281798 0.418681
Brugia malayi SRC-1 0.00952524 0.0142402 0.0211574
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.105475 0.281798 0.418681
Brugia malayi proprotein convertase 2 0.0700674 0.183063 0.271986
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00952524 0.0142402 0.0142402
Chlamydia trachomatis SWIB complex protein 0.00547619 0.00294937 0.5
Loa Loa (eye worm) hypothetical protein 0.114005 0.305585 0.454023
Schistosoma mansoni amine GPCR 0.105475 0.281798 0.418681
Echinococcus granulosus neuropeptides capa receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Onchocerca volvulus 0.105475 0.281798 0.693931
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi G-protein coupled receptor 0.105475 0.281798 0.418681
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.00720782 0.00777807 0.00720581
Entamoeba histolytica histone deacetylase, putative 0.245787 0.67306 1
Brugia malayi Pepsin A precursor 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.105475 0.281798 0.281798
Echinococcus multilocularis Tubulin beta 2C chain 0.103939 0.277516 0.277516
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus Furin 1 0.0254505 0.0586481 0.0586481
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Trichomonas vaginalis tubulin, putative 0.103939 0.277516 0.409732
Schistosoma mansoni hypothetical protein 0.0055626 0.00319033 0.00474004
Brugia malayi ORL1-like opioid receptor 0.105475 0.281798 0.418681
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.105475 0.281798 0.281798
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.105475 0.281798 0.418681
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis G protein coupled receptor 139 0.105475 0.281798 0.281798
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.187788 0.511329 0.511329
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.105475 0.281798 0.418681
Plasmodium falciparum histone deacetylase, putative 0.201659 0.55001 0.816373
Schistosoma mansoni hypothetical protein 0.00547619 0.00294937 0.00438203
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.105475 0.281798 0.418681
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Loa Loa (eye worm) SRC-1 0.00952524 0.0142402 0.0211574
Schistosoma mansoni bcl-2 homologous antagonist/killer (bak) 0.0055626 0.00319033 0.00474004
Schistosoma mansoni biogenic amine receptor 0.105475 0.281798 0.418681
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.105475 0.281798 0.418681
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Entamoeba histolytica tubulin family protein 0.103939 0.277516 0.40712
Echinococcus granulosus rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Echinococcus granulosus sex peptide receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis histone deacetylase 6 0.208867 0.570109 0.570109
Loa Loa (eye worm) hypothetical protein 0.0055626 0.00319033 0.00474004
Plasmodium vivax histone deacetylase, putative 0.126011 0.339062 0.501578
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Onchocerca volvulus 0.150047 0.406089 1
Schistosoma mansoni tyrosine kinase 0.00952524 0.0142402 0.0211574
Echinococcus granulosus histone deacetylase 1 0.245787 0.67306 0.67306
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Loa Loa (eye worm) hypothetical protein 0.114005 0.305585 0.454023
Loa Loa (eye worm) histone deacetylase 7A 0.201659 0.55001 0.817177
Schistosoma mansoni opsin-like receptor 0.105475 0.281798 0.418681
Brugia malayi hypothetical protein 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0254505 0.0586481 0.0831186
Echinococcus granulosus neuropeptide s receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Schistosoma mansoni integrin alpha-ps 0.00678746 0.00660587 0.00981468
Loa Loa (eye worm) camk/mapkapk/mapkapk protein kinase 0.0228397 0.051368 0.07632
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Brugia malayi RE15519p 0.105475 0.281798 0.418681
Trypanosoma cruzi histone deacetylase, putative 0.201659 0.55001 0.81504
Loa Loa (eye worm) aspartyl protease 6 0.00570411 0.00358495 0.00532634
Plasmodium vivax aspartyl protease, putative 0.00570411 0.00358495 0.000948462
Loa Loa (eye worm) hypothetical protein 0.0229418 0.0516525 0.0767427
Schistosoma mansoni adenoreceptor 0.105475 0.281798 0.418681
Brugia malayi follicle stimulating hormone receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Echinococcus granulosus tm gpcr rhodopsin 0.363032 1 1
Schistosoma mansoni histone deacetylase 0.245787 0.67306 1
Echinococcus multilocularis serotonin receptor 0.114005 0.305585 0.305585
Brugia malayi hypothetical protein 0.00570411 0.00358495 0.00532634
Trypanosoma cruzi histone deacetylase, putative 0.103069 0.275089 0.4018
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0634535 0.16462 0.16462
Echinococcus granulosus neuroendocrine convertase 2 0.0700674 0.183063 0.183063
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis neuropeptide Y receptor 0.105475 0.281798 0.281798
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.00720782 0.00777807 0.00720581
Echinococcus granulosus 7TM GPCR rhodopsin 0.105475 0.281798 0.281798
Brugia malayi Tyrosine-protein kinase abl-1 0.0120269 0.0212163 0.0315221
Schistosoma mansoni integrin alpha 0.0165479 0.0338231 0.0502528
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Schistosoma mansoni biogenic amine (dopamine) receptor 0.105475 0.281798 0.418681
Schistosoma mansoni hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.123842 0.333016 0.494778
Brugia malayi SH2 domain containing protein 0.0065989 0.00608009 0.00903349
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus Tubulin beta 2C chain 0.103939 0.277516 0.277516
Schistosoma mansoni amine GPCR 0.105475 0.281798 0.418681
Toxoplasma gondii histone deacetylase HDAC3 0.245787 0.67306 1
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.00570411 0.00358495 0.00532634
Trichomonas vaginalis conserved hypothetical protein 0.0220028 0.0490342 0.068772
Plasmodium falciparum plasmepsin VIII, putative 0.00570411 0.00358495 0.000948462
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Trichomonas vaginalis tubulin epsilon chain, putative 0.103939 0.277516 0.409732
Echinococcus granulosus neuropeptide Y receptor 0.105475 0.281798 0.281798
Echinococcus granulosus Upstream activation factor subunit UAF30 0.00547619 0.00294937 0.00294937
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Brugia malayi GnHR receptor homolog 0.197822 0.53931 0.80128
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Loa Loa (eye worm) aspartic protease BmAsp-1 0.00570411 0.00358495 0.00532634
Schistosoma mansoni neuropeptide receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.00720782 0.00777807 0.0115563
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.00720782 0.00777807 0.0115563
Brugia malayi Dopamine receptor protein 2 0.105475 0.281798 0.418681
Echinococcus multilocularis rhodopsin orphan GPCR 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.0197902 0.0428643 0.0636856
Giardia lamblia Beta tubulin 0.103939 0.277516 0.405448
Echinococcus granulosus biogenic amine 5HT receptor 0.142036 0.38375 0.38375
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni serine/threonine protein kinase 0.0228397 0.051368 0.07632
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Echinococcus granulosus MAP kinase activated protein kinase 2 0.0228397 0.051368 0.051368
Loa Loa (eye worm) hypothetical protein 0.00570411 0.00358495 0.00532634
Echinococcus multilocularis BRCA1 associated protein 0.00720782 0.00777807 0.00777807
Trypanosoma cruzi histone deacetylase 1, putative 0.245787 0.67306 1
Schistosoma mansoni biogenic amine (dopamine) receptor 0.105475 0.281798 0.418681
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.105475 0.281798 0.281798
Schistosoma mansoni tubulin subunit beta 0.103939 0.277516 0.412319
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Brugia malayi hypothetical protein 0.105475 0.281798 0.418681
Loa Loa (eye worm) BEN-1 protein 0.103939 0.277516 0.412319
Echinococcus multilocularis tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Echinococcus multilocularis tyrosine protein kinase ABL1 0.0243516 0.0555837 0.0555837
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0359448 0.0879118 0.130615
Schistosoma mansoni biogenic amine (dopamine) receptor 0.105475 0.281798 0.418681
Brugia malayi Integrin alpha pat-2 precursor 0.0165479 0.0338231 0.0502528
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00952524 0.0142402 0.0142402
Brugia malayi sulfakinin receptor protein 0.105475 0.281798 0.418681
Echinococcus multilocularis Upstream activation factor subunit UAF30 0.00547619 0.00294937 0.00294937
Echinococcus multilocularis tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Loa Loa (eye worm) hypothetical protein 0.12836 0.345613 0.513495
Onchocerca volvulus Uncharacterized RING finger protein homolog 0.00720782 0.00777807 0.0191536
Schistosoma mansoni hypothetical protein 0.231882 0.634287 0.942392
Toxoplasma gondii histone deacetylase HDAC1 0.201659 0.55001 0.816373
Trichomonas vaginalis histone deacetylase, putative 0.245787 0.67306 1
Echinococcus multilocularis tubulin subunit beta 0.103939 0.277516 0.277516
Entamoeba histolytica Sir2 family transcriptional regulator, putative 0.00720782 0.00777807 0.00281204
Echinococcus granulosus furin 0.10807 0.289035 0.289035
Schistosoma mansoni biogenic amine (5HT) receptor 0.114005 0.305585 0.454023
Echinococcus multilocularis histone deacetylase 8 0.103069 0.275089 0.275089
Echinococcus multilocularis Furin 1 0.0254505 0.0586481 0.0586481
Loa Loa (eye worm) TK protein kinase 0.00804893 0.0101235 0.015041
Loa Loa (eye worm) apoptosis regulator protein 0.0055626 0.00319033 0.00474004
Echinococcus multilocularis Tubulin beta 2C chain 0.103939 0.277516 0.277516
Echinococcus multilocularis histone deacetylase 3 0.245787 0.67306 0.67306
Echinococcus granulosus beta tubulin 0.103939 0.277516 0.277516
Echinococcus multilocularis biogenic amine (5HT) receptor 0.142036 0.38375 0.38375
Onchocerca volvulus 0.105475 0.281798 0.693931
Echinococcus multilocularis tyrosine protein kinase csk 0.00508501 0.00185858 0.00185858
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00952524 0.0142402 0.0142402
Onchocerca volvulus 0.105475 0.281798 0.693931
Schistosoma mansoni rhodopsin-like orphan GPCR 0.105475 0.281798 0.418681
Brugia malayi BRCA1-associated protein 2 containing protein 0.00720782 0.00777807 0.0115563
Echinococcus multilocularis somatostatin receptor 0.105475 0.281798 0.281798
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus g protein coupled receptor 0.105475 0.281798 0.281798
Echinococcus multilocularis beta tubulin 0.103939 0.277516 0.277516
Schistosoma mansoni tyrosine kinase 0.00952524 0.0142402 0.0211574
Leishmania major beta tubulin 0.103939 0.277516 0.405448
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.105475 0.281798 0.281798
Schistosoma mansoni neuropeptide receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi Integrin alpha cytoplasmic region family protein 0.0114523 0.0196139 0.0291413
Echinococcus granulosus biogenic amine 5HT receptor 0.114005 0.305585 0.305585
Brugia malayi Serotonin/octopamine receptor family protein 7 0.105475 0.281798 0.418681
Schistosoma mansoni hypothetical protein 0.00547619 0.00294937 0.00438203
Schistosoma mansoni neuropeptide F-like receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Brugia malayi Serotonin receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.0114523 0.0196139 0.0291413
Echinococcus granulosus Tubulin beta 2C chain 0.103939 0.277516 0.277516
Loa Loa (eye worm) hypothetical protein 0.105798 0.282699 0.42002
Echinococcus granulosus beta tubulin 0.103939 0.277516 0.277516
Echinococcus multilocularis histone deacetylase 6 0.201659 0.55001 0.55001
Echinococcus multilocularis histone deacetylase 1 0.245787 0.67306 0.67306
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.105475 0.281798 0.281798
Echinococcus granulosus tyrosine protein kinase Fyn 0.00952524 0.0142402 0.0142402
Echinococcus granulosus 7tm_1 domain containing protein 0.105475 0.281798 0.281798
Echinococcus multilocularis g protein coupled receptor 0.105475 0.281798 0.281798
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.00720782 0.00777807 0.00281204
Echinococcus granulosus Tubulin beta 2C chain 0.103939 0.277516 0.277516
Schistosoma mansoni brca1-associated protein (brap2) 0.00720782 0.00777807 0.0115563
Schistosoma mansoni neuropeptide f receptor 76f 0.105475 0.281798 0.418681
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00804893 0.0101235 0.0101235
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0254505 0.0586481 0.0871364
Echinococcus granulosus nuclear receptor co repressor related ncor 0.351159 0.966893 0.966893
Loa Loa (eye worm) pigment dispersing factor receptor c 0.00517099 0.00209832 0.00311758
Schistosoma mansoni neuropeptide receptor 0.105475 0.281798 0.418681
Loa Loa (eye worm) hypothetical protein 0.105475 0.281798 0.418681
Echinococcus granulosus tubulin subunit beta 0.103939 0.277516 0.277516
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.00720782 0.00777807 0.0115563
Echinococcus multilocularis neuropeptides capa receptor 0.105475 0.281798 0.281798
Leishmania major beta tubulin 0.103939 0.277516 0.405448

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 0.0513 uM Antiprotozoal activity against trophozoite stage of Entamoeba histolytica HM-1:IMSS assessed as growth inhibition after 48 hrs by haemocytometric analysis ChEMBL. 23731944
IC50 (functional) = 0.0926 uM Antiprotozoal activity against trophozoite stage of Trichomonas vaginalis GT3 assessed as growth inhibition after 48 hrs by haemocytometric analysis ChEMBL. 23731944

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Entamoeba histolytica 23731944
Trichomonas vaginalis ChEMBL23 23731944

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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