Detailed information for compound 67873

Basic information

Technical information
  • TDR Targets ID: 67873
  • Name: Vinblastine
  • MW: 810.974 | Formula: C46H58N4O9
  • H donors: 3 H acceptors: 5 LogP: 4.74 Rotable bonds: 10 Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2N(C)[C@@H]3[C@@]4(c2cc1[C@]1(C[C@H]2CN(CCc5c1[nH]c1c5cccc1)C[C@](C2)(O)CC)C(=O)OC)CCN1[C@H]4[C@@]([C@H]([C@]3(O)C(=O)OC)OC(=O)C)(CC)C=CC1
  • InChi: 1S/C46H58N4O9/c1-8-42(54)23-28-24-45(40(52)57-6,36-30(15-19-49(25-28)26-42)29-13-10-11-14-33(29)47-36)32-21-31-34(22-35(32)56-5)48(4)38-44(31)17-20-50-18-12-16-43(9-2,37(44)50)39(59-27(3)51)46(38,55)41(53)58-7/h10-14,16,21-22,28,37-39,47,54-55H,8-9,15,17-20,23-26H2,1-7H3/t28-,37-,38+,39+,42-,43+,44+,45-,46-/m0/s1
  • InChiKey: JXLYSJRDGCGARV-CFWMRBGOSA-N  

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Synonyms

  • Nincaluicolflastine
  • Rozevin
  • VR-8
  • Vinblastin
  • Vinblastina [DCIT]
  • Vinblastinum [INN-Latin]
  • Vincaleucoblastin
  • Vincoblastine
  • BSPBio_001228
  • STOCK1N-38480
  • nchembio873-comp22
  • (2ALPHA,2'BETA,3BETA,4ALPHA,5BETA)-VINCALEUKOBLASTINE
  • (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-methyl 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-1H-indolizino(8,1-cd)carbazole-5-carboxylate
  • 1H-Indolizino(8,1-cd)carbazole-5-carboxylic acid, 4-(acetyloxy)-3a-ethyl-9-(5-ethyl-1,4,5,6,7,8,9,10-octahydro-5-hydroxy-9-(methoxycarbonyl)-2H-3,7-methanoazacycloundecino(5,4-b)indol-9-yl)-3a,4,5,5a,6,11,12,13a-octahydro-5-hydroxy-8-methoxy-6-methyl-, methyl ester, (3aR-(3aalpha,4beta,5beta,5abeta,9(3R*,5S*,7R*,9S*),10bR*,13aalpha))-
  • EINECS 212-734-0
  • HSDB 3263
  • NCI-C04842
  • NDC 0002-1452-01
  • NSC 47842

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major epsilon tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Homo sapiens tubulin, beta 8 class VIII References
Homo sapiens geminin, DNA replication inhibitor Starlite/ChEMBL References
Homo sapiens tubulin, beta 4A class IVa References
Homo sapiens SMAD family member 2 Starlite/ChEMBL References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Mus musculus ATP-binding cassette, sub-family B (MDR/TAP), member 1B Starlite/ChEMBL References
Homo sapiens tubulin, beta 6 class V References
Homo sapiens solute carrier organic anion transporter family, member 1B1 Starlite/ChEMBL References
Homo sapiens tubulin, alpha 1b References
Homo sapiens tubulin, alpha 3d References
Leishmania major beta tubulin Curated by TDR Targets References
Oryctolagus cuniculus Arachidonate 15-lipoxygenase Starlite/ChEMBL References
Leishmania major zeta tubulin, putative Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL References
Leishmania major beta tubulin Curated by TDR Targets References
Homo sapiens tubulin, alpha 1a References
Plasmodium falciparum tubulin beta chain Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Sus scrofa Tubulin Starlite/ChEMBL References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Rattus norvegicus Thioredoxin reductase 1, cytoplasmic Starlite/ChEMBL References
Mus musculus RAR-related orphan receptor gamma Starlite/ChEMBL References
Homo sapiens tubulin, alpha 3e References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL References
Homo sapiens tubulin, alpha 1c References
Homo sapiens tubulin, beta 4B class IVb References
Bos taurus Tubulin Starlite/ChEMBL References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Homo sapiens ATP-binding cassette, sub-family B (MDR/TAP), member 1 Starlite/ChEMBL References
Leishmania major alpha tubulin Curated by TDR Targets References
Leishmania donovani Beta tubulin Starlite/ChEMBL References
Leishmania major alpha tubulin Curated by TDR Targets References
Homo sapiens tubulin, beta 1 class VI References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major delta tubulin, putative Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Homo sapiens tubulin, beta 2B class IIb Starlite/ChEMBL References
Leishmania major beta tubulin Curated by TDR Targets References
Homo sapiens thromboxane A synthase 1 (platelet) Starlite/ChEMBL References
Leishmania major gamma-tubulin Curated by TDR Targets References
Leishmania major beta tubulin Curated by TDR Targets References
Leishmania major alpha tubulin Curated by TDR Targets References
Homo sapiens tubulin, beta 2A class IIa References
Homo sapiens solute carrier organic anion transporter family, member 1B3 Starlite/ChEMBL References
Homo sapiens tubulin, alpha 4a References
Leishmania major beta tubulin Curated by TDR Targets References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Brugia malayi tubulin alpha chain - mouse Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Neospora caninum tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii alpha-tubulin I, putative Get druggable targets OG5_126605 All targets in OG5_126605
Babesia bovis tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Onchocerca volvulus Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) MH2 domain-containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans potential ABC transporter similar to S. cerevisiae STE6 (YKL209C) involved in peptide pheromone export Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Trypanosoma brucei zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania braziliensis delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Plasmodium yoelii tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii beta-1 tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Tubulin beta-7 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium berghei alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-4 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium yoelii tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium falciparum glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum ATP-binding cassette sub-family B member 5, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma congolense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica tubulin alpha-1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Schistosoma japonicum Bile salt export pump, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium knowlesi alpha-tubulin II, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K10389 tubulin gamma, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis taga, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus 5'partial|ATP binding cassette sub family B Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Plasmodium yoelii glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) alpha-tubulin isotype 2 Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin beta-1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica P-glycoprotein-5 Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus peroxisome assembly protein 26 Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-4 chain Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi ABC transporter family protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium yoelii Tubulin/FtsZ family, putative Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma congolense zeta tubulin Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Babesia bovis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania braziliensis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis hypothetical protein Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum thioredoxin reductase 1 Get druggable targets OG5_126785 All targets in OG5_126785
Brugia malayi MH2 domain containing protein Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin beta 1 chain Get druggable targets OG5_126611 All targets in OG5_126611
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Toxoplasma gondii ATP-binding cassette transporter ABC.B1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium berghei multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma brucei gambiense delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis p-glycoprotein-like protein,ABC transporter-like protein,multidrug resistance protein-like protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Plasmodium vivax thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Toxoplasma gondii alpha tubulin TUBA1 Get druggable targets OG5_126605 All targets in OG5_126605
Candida albicans similar to S. cerevisiae GLR1 (YPL091W) glutathione oxidoreductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Toxoplasma gondii tubulin/FtsZ family, GTPase domain-containing protein Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis tubulin gamma 1 chain Get druggable targets OG5_127652 All targets in OG5_127652
Toxoplasma gondii thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium falciparum tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania donovani zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans cytoskeletal structural protein Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium parvum ATP-binding cassette transporter Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis ATP-binding cassette protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis thioredoxin glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum Multidrug resistance protein 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Cryptosporidium hominis alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus multilocularis tubulin, beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin subunit TubB Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania mexicana p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum delta tubulin, putative Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Loa Loa (eye worm) tubulin alpha 2 Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni multidrug resistance protein Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Neospora caninum tubulin delta chain, putative Get druggable targets OG5_143817 All targets in OG5_143817
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis ABC transporter, half transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania mexicana gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium vivax tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Toxoplasma gondii ABC transporter transmembrane region domain-containing protein Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania donovani epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Neospora caninum MGC84926 protein, related Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica P-glyco protein 6, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva thioredoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Plasmodium berghei tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum Glutathione reductase, related Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus granulosus tubulin epsilon chain Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma congolense alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma mansoni smdr2 Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei gambiense gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Neospora caninum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania donovani p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Schistosoma japonicum Tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania mexicana epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania mexicana beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma congolense tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Loa Loa (eye worm) ATP-binding cassette sub-family B member 2 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium parvum tubulin beta chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus tubulin alpha 3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin epsilon chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tubulin alpha chain Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi alpha tubulin, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania mexicana trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania infantum epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin gamma chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum ko:K07375 tubulin beta, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Leishmania braziliensis alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus tubulin beta 4A class IVa Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus granulosus ATP binding cassette subfamily B MDR:TAP Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni tubulin subunit beta Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit gamma Get druggable targets OG5_127652 All targets in OG5_127652
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania infantum alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum ko:K00384 thioredoxin reductase (NADPH) [EC1.8.1.9], putative Get druggable targets OG5_126785 All targets in OG5_126785
Mycobacterium tuberculosis Probable transmembrane multidrug efflux pump Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus granulosus tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin alpha 1 chain Get druggable targets OG5_126605 All targets in OG5_126605
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr Get druggable targets OG5_126785 All targets in OG5_126785
Plasmodium falciparum tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Giardia lamblia Epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Entamoeba histolytica P-glycoprotein-2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Brugia malayi Thioredoxin reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis tubulin alpha 1C chain Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin alpha-2/alpha-4 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin gamma chain, putative Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis abcb9, putative Get druggable targets OG5_126596 All targets in OG5_126596
Theileria parva tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Loa Loa (eye worm) transcription factor SMAD2 Get druggable targets OG5_131716 All targets in OG5_131716
Leishmania mexicana zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium falciparum alpha tubulin 1 Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma cruzi zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania donovani tubulin delta chain Get druggable targets OG5_143817 All targets in OG5_143817
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K05659 ATP-binding cassette, subfamily B (MDR/TAP), member 4, putative Get druggable targets OG5_126596 All targets in OG5_126596
Candida albicans gamma tubulin-like protein Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma brucei trypanothione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Echinococcus multilocularis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium knowlesi glutathione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Schistosoma japonicum ko:K07374 tubulin alpha, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis tubulin alpha-1 chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Loa Loa (eye worm) BEN-1 protein Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin alpha chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum ko:K10391 tubulin epsilon, putative Get druggable targets OG5_130726 All targets in OG5_130726
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit alpha Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trypanosoma cruzi beta tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium vivax tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major gamma-tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Trypanosoma congolense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica tubulin family protein Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi beta-tubulin, identical Get druggable targets OG5_126611 All targets in OG5_126611
Brugia malayi multidrug resistance protein 3 Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani tubulin gamma chain Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania infantum p-glycoprotein Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma japonicum Tubulin alpha-1C chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Cryptosporidium hominis beta-catenin-like repeat protein Get druggable targets OG5_126611 All targets in OG5_126611
Entamoeba histolytica P-glycoprotein-2 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma mansoni alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva Tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Brugia malayi Tubulin alpha-2 chain Get druggable targets OG5_126605 All targets in OG5_126605
Theileria parva tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania braziliensis beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Babesia bovis thiodoxin reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Trypanosoma cruzi trypanothione reductase, putative Get druggable targets OG5_126785 All targets in OG5_126785
Cryptosporidium parvum gamma tubulin Get druggable targets OG5_127652 All targets in OG5_127652
Leishmania braziliensis epsilon tubulin, putative Get druggable targets OG5_130726 All targets in OG5_130726
Schistosoma japonicum Multidrug resistance protein 3, putative Get druggable targets OG5_126596 All targets in OG5_126596
Echinococcus multilocularis ATP binding cassette subfamily B (MDR:TAP) Get druggable targets OG5_126596 All targets in OG5_126596
Giardia lamblia Beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Trichomonas vaginalis multidrug resistance protein 1, 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis beta-tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum hypothetical protein Get druggable targets OG5_126596 All targets in OG5_126596
Toxoplasma gondii beta-tubulin, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trichomonas vaginalis ABC transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis ATP-binding cassette transporter, putative Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Plasmodium berghei tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Brugia malayi alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Plasmodium knowlesi tubulin epsilon chain, putative Get druggable targets OG5_130726 All targets in OG5_130726
Echinococcus granulosus Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Schistosoma mansoni tubulin subunit epsilon Get druggable targets OG5_130726 All targets in OG5_130726
Trypanosoma congolense beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) glutathione reductase Get druggable targets OG5_126785 All targets in OG5_126785
Loa Loa (eye worm) tubulin alpha-3 chain Get druggable targets OG5_126605 All targets in OG5_126605
Echinococcus multilocularis Tubulin beta 2C chain Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum Beta-tubulin, related Get druggable targets OG5_127652 All targets in OG5_127652
Entamoeba histolytica P-glycoprotein-1 Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Echinococcus granulosus multidrug resistance protein 1 Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) tubulin beta-2A chain Get druggable targets OG5_126611 All targets in OG5_126611
Loa Loa (eye worm) alpha-tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania donovani ATP-binding cassette protein subfamily B, member 2, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania braziliensis zeta tubulin, putative Get druggable targets OG5_145938 All targets in OG5_145938
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Schistosoma japonicum Tubulin beta-1 chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania mexicana alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trypanosoma brucei beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Neospora caninum ATP-binding cassette, sub-family B (MDR/TAP), member 4, related Get druggable targets OG5_126596 All targets in OG5_126596
Schistosoma japonicum Multidrug resistance protein 1, putative Get druggable targets OG5_126596 All targets in OG5_126596
Trichomonas vaginalis tubulin beta chain, putative Get druggable targets OG5_126611 All targets in OG5_126611
Leishmania major alpha tubulin Get druggable targets OG5_126605 All targets in OG5_126605
Trichomonas vaginalis lipid A export ATP-binding/permease protein msba, putative Get druggable targets OG5_126596 All targets in OG5_126596
Leishmania major beta tubulin Get druggable targets OG5_126611 All targets in OG5_126611
Trypanosoma brucei gambiense epsilon tubulin Get druggable targets OG5_130726 All targets in OG5_130726
Plasmodium falciparum alpha tubulin 2 Get druggable targets OG5_126605 All targets in OG5_126605
Chlamydia trachomatis ABC transporter ATP binding protein/permease Get druggable targets OG5_126596 All targets in OG5_126596
Babesia bovis tubulin alpha chain, putative Get druggable targets OG5_126605 All targets in OG5_126605
Entamoeba histolytica P-glycoprotein 5, putative Get druggable targets OG5_126596 All targets in OG5_126596

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Rattus norvegicus dihydrolipoyl dehydrogenase, apicoplast Thioredoxin reductase 1, cytoplasmic   499 aa 506 aa 23.7 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 2B class IIb 445 aa 438 aa 32.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Oryctolagus cuniculus arachidonate 5 lipoxygenase Arachidonate 15-lipoxygenase   663 aa 676 aa 23.2 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin epsilon chain, putative gamma-tubulin 447 aa 479 aa 28.2 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Trypanosoma brucei cytochrome P450, putative thromboxane A synthase 1 (platelet) 534 aa 498 aa 21.5 %
Leishmania donovani alpha tubulin 2 Beta tubulin   43 aa 39 aa 46.2 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 1 class VI 451 aa 438 aa 32.2 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Brugia malayi Hypothetical 65.5 kDa Trp-Asp repeats containing protein F02E8.5 inchromosome X geminin, DNA replication inhibitor 209 aa 176 aa 27.8 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 4B class IVb 445 aa 438 aa 32.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain tubulin beta chain 445 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Bos taurus tubulin gamma chain Tubulin   445 aa 438 aa 32.9 %
Rattus norvegicus hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Sus scrofa tubulin gamma chain Tubulin   445 aa 438 aa 32.6 %
Brugia malayi sodium-independent organic anion transporter family protein solute carrier organic anion transporter family, member 1B1 691 aa 634 aa 27.3 %
Candida albicans vacuolar ABC transporter similar to multiple drug resistance-associated protein ATP-binding cassette, sub-family B (MDR/TAP), member 1B 1276 aa 1206 aa 23.3 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 8 class VIII 444 aa 438 aa 33.8 %
Candida albicans similar to vacuolar membrane ATP-dependant transporter, metal resistance protein ATP-binding cassette, sub-family B (MDR/TAP), member 1 1280 aa 1109 aa 23.1 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Brugia malayi sodium-independent organic anion transporter family protein solute carrier organic anion transporter family, member 1B3 702 aa 652 aa 28.4 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain tubulin, beta 6 class V 446 aa 438 aa 32.4 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %
Trypanosoma brucei epsilon tubulin epsilon tubulin, putative 470 aa 488 aa 68.0 %
Brugia malayi MH2 domain containing protein SMAD family member 2 467 aa 405 aa 31.6 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain alpha tubulin 451 aa 457 aa 30.9 %
Plasmodium falciparum tubulin gamma chain beta tubulin 443 aa 438 aa 33.6 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species

Activities

Activity type Activity value Assay description Source Reference
% maximum response (binding) = 24.4 % Inhibition of Pgp expressed in MDR1-MDCKII cells measured by calcein-AM assay ChEMBL. 11602674
Activity (binding) Inhibition of mouse brain MAOA ChEMBL. 18834112
Activity (binding) Inhibition of mouse brain MAOB ChEMBL. 18834112
Activity (binding) Induction of human MDR1 ATPase activity assessed as inorganic phosphate production in presence of MDR1 inhibitor cyclosporin A ChEMBL. 21348461
Activity (functional) TP_TRANSPORTER: cell accumulation in P-gp transfected LNCaP cells ChEMBL. 14991868
Activity (ADMET) Substrates of transporters of clinical importance in the absorption and disposition of drugs, MDR3 ChEMBL. 20190787
Activity (functional) TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing MDCKII cells ChEMBL. 14706813
Activity (functional) TP_TRANSPORTER: cell accumulation in CCRF-CEM and CEM/VLB100 cells ChEMBL. 10411602
Activity (functional) TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.5 uM, Vinblastine: 70 uM) in MDR1-expressing NIH-3T3 cells ChEMBL. 14985103
Activity (functional) TP_TRANSPORTER: increase in Glibenclamide intracellular accumulation (Glibenclamide: 0.0525 uM, Vinblastine: 100 uM) in CC531mdr+ cells ChEMBL. 10087141
Activity (functional) TP_TRANSPORTER: transepithelial transport in the presence of of Vinblastine at 0.1 uM in Caco-2 cells ChEMBL. 12948019
Activity (binding) Induction of human MDR1 ATPase activity assessed as inorganic phosphate production ChEMBL. 21348461
Activity (functional) TP_TRANSPORTER: increase in Colchicine intracellular accumulation (Colchicine: 0.0175 uM, Vinblastine: 100 uM) in CEM/VLB600 cells ChEMBL. 10087141
Activity (functional) TP_TRANSPORTER: uptake (apical to cell) in OCT2-expressing NIH3T3 cells ChEMBL. 10220855
Activity (functional) TP_TRANSPORTER: transepithelial transport in MDR1-expressing LLC-PK1 cells ChEMBL. 12604693
Activity (functional) TP_TRANSPORTER: cell accumulation in KB-3-1 and KB-V1 cells ChEMBL. 11181899
Activity (functional) TP_TRANSPORTER: inhibition of Azidopine photoaffinity labelling (Azidopine: 0.4 uM, Vinblastine: 400 uM) in membranes from MDR1-expressing LLC-PK1 cells ChEMBL. 10746169
Activity (functional) Activity against human TK1 assessed as thymidine phosphorylation relative to thymidine ChEMBL. 16870428
Activity (functional) TP_TRANSPORTER: inhibition of photolabeling by IAARh123 (IAARh123: 1 uM, VBL: 1000 uM) in membranes from Mrp6-expressing P. pastoris ChEMBL. 12069597
Activity (functional) TP_TRANSPORTER: increase in brain concentration in mdr1a(-/-) mouse ChEMBL. 11181899
Activity (functional) TP_TRANSPORTER: inhibition of TBuMA transepithelial transport (basal to apical)(TBuMA: 10 uM, Vinblastine: 2 uM) in MDR1-expressing LLC-PK1 cells ChEMBL. 9655875
Activity (functional) TP_TRANSPORTER: increase in Colchicine intracellular accumulation (Colchicine: 0.035 uM, Vinblastine: 100 uM) in CC531mdr+ cells ChEMBL. 10087141
Activity (functional) TP_TRANSPORTER: Western blot, primary hepatocytes ChEMBL. 11323161
Activity (functional) TP_TRANSPORTER: Northern blot from primary hepatocytes ChEMBL. 11323161
Activity (functional) TP_TRANSPORTER: efflux in MDR1-expressing BeWo cells ChEMBL. 12724138
Activity (functional) TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical)(Digoxin: 0.1uM, Vinblastine: 20 uM) in MDR1-expressing LLC-PK1 cells ChEMBL. 1359120
Activity (functional) TP_TRANSPORTER: inhibition of TBuMA transepithelial transport (basal to apical)(TBuMA: 10 uM, Vinblastine: 2 uM) in Mdr1a-expressing LLC-PK1 cells ChEMBL. 9655875
Activity (functional) 0 Induction of microtubule loss in rat A10 cells at 5 uM after 24 hrs ChEMBL. 17567121
Activity (functional) 0 Increase in caspase 3 activation in Jurkat cells at 1 uM ChEMBL. 17894480
Activity (functional) 0 Effect on apoptosis in Jurkat cells assessed as cleavage of procasapase 3 to active enzyme at 1 uM ChEMBL. 17894480
Activity (functional) 0 Effect on apoptosis in Jurkat cells assessed as cleavage of PARP at 1 uM ChEMBL. 17894480
Activity (functional) 0 Cytotoxicity against human Jurkat cells ChEMBL. 18182300
Activity (functional) 0 Cytotoxicity against human MDA-MB-231 cells ChEMBL. 18182300
Activity (ADMET) = 6.06 % Genotoxicity in human lymphocytes assessed as micronucleated binucleate cells level at 0.03 ug/mL incubated for 24 hrs measured under no recovery condition in absence of rat liver S9 fraction (Rvb = 0.50%) ChEMBL. 21353728
Activity (functional) = 6.6 % Cell cycle arrest in HL60 cells assessed as accmulation in S phase at 80 nM ChEMBL. 17567121
Activity (functional) = 6.6 % Cell cycle arrest in HL60 cells assessed as accmulation in S phase at 80 nM ChEMBL. 17567121
Activity (functional) = 10.1 % Cell cycle arrest in HL60 cells assessed as accmulation in G0/M phase at 80 nM ChEMBL. 17567121
Activity (functional) = 10.1 % Cell cycle arrest in HL60 cells assessed as accmulation in G0/M phase at 80 nM ChEMBL. 17567121
Activity (functional) = 21 % Cytotoxicity against human MDA-MB-435 cells assessed as cell viability at 1 nM after 72 hrs ChEMBL. 25093280
Activity (binding) = 25 % Inhibition of beta tubulin nucleotide site assessed as inhibition of displacement of cold GDP by [alpha32P]GTP at 20 uM by rapid filtration technique ChEMBL. 19072542
Activity (functional) = 29 % TP_TRANSPORTER: inhibition of LTC4 uptake (LTC4: 0.01 uM, Vinblastine: 100 uM) in liver plasma membrane vesicles of Wistar rat ChEMBL. 2172249
Activity (functional) = 30 % Ability of the compound to induce cells in S phase ChEMBL. 15369401
Activity (functional) = 30 % Induction of apoptosis in human A549 cells assessed as late apoptotic cells at 100 nM after 24 hrs by FITC-annexin V/propidium iodide staining-based flow cytometric analysis relative to control ChEMBL. 26176165
Activity (binding) = 31 % Inhibition of P-gp ATPase activity in human DC-3F/ADX cells assessed as increase in basal activity measured by NADH level at 0.5 uM by spectrophotometric method ChEMBL. 19243953
Activity (functional) = 33 % Ability of the compound to induce cells in G0/G1 phase ChEMBL. 15369401
Activity (binding) = 35 % Inhibition of P-gp ATPase activity in human DC-3F/ADX cells assessed as increase in basal activity measured by NADH level at 5 uM by spectrophotometric method ChEMBL. 19243953
Activity (functional) = 37 % Ability of the compound to induce cells in G2/M phase ChEMBL. 15369401
Activity (functional) = 42 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 120 mins relative to control ChEMBL. 17064079
Activity (functional) = 42 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 120 mins relative to control ChEMBL. 17064079
Activity (functional) = 44 % TP_TRANSPORTER: inhibition of Ivermectin binding (IVM: 0.2 uM, Vinblastine: 300-fold molar excess) in plasma membranes from CEM/VLB1.0 cells ChEMBL. 8960059
Activity (functional) = 49 % Antiproliferative activity against human MDA-MB-435 cells assessed as cell viability at 1 ng/ml after 96 hrs ChEMBL. 22980217
Activity (binding) = 50 % Displacement of [3H]-VBL from porcine tubulin after 60 mins relative to control ChEMBL. 24223237
Activity (ADMET) = 51.5 % Cytotoxicity against human MRC5 cells assessed as metabolic active cells at 100 uM after 72 hrs by XTT assay relative to control ChEMBL. 21106378
Activity (ADMET) = 60.06 % Cytotoxicity against human MRC5 cells assessed as cell viability at 0.12 uM after 72 hrs by XTT proliferation assay ChEMBL. 21429630
Activity (functional) = 72 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 90 mins relative to control ChEMBL. 17064079
Activity (functional) = 72 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 90 mins relative to control ChEMBL. 17064079
Activity (functional) = 75 % TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in Caco-2 cells ChEMBL. 12699389
Activity (binding) = 78 % Effect on human MRP2-mediated estradiol-17-beta-glucuronide transport in Sf9 cells inverted membrane vesicles relative to control ChEMBL. 18457386
Activity (functional) = 80 % Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 20 nM after 24 hrs by propidium iodide staining based flow cytometry analysis (Rvb = 0.10 %) ChEMBL. 22044164
Activity (functional) > 80 % Cell cycle arrest in human HeLa cells assessed as accumulation at G2/M phase at 20 nM after 24 hrs by propidium iodide staining-based flow cytometric analysis ChEMBL. 26132075
Activity (functional) = 81 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 60 mins relative to control ChEMBL. 17064079
Activity (functional) = 81 % Inhibition of ATPase measured as ATP availability in Caco2 cells at 20 nM after 60 mins relative to control ChEMBL. 17064079
Activity (functional) = 83.3 % Cell cycle arrest in HL60 cells assessed as accmulation in G0/G1 phase at 80 nM ChEMBL. 17567121
Activity (functional) = 83.3 % Cell cycle arrest in HL60 cells assessed as accmulation in G0/G1 phase at 80 nM ChEMBL. 17567121
Activity (functional) = 2.3 nM Antiproliferative activity against human HeLa cells assessed as median dose after 24 hrs ChEMBL. 23445405
Activity (functional) = 33 nM/mg*min Inhibition of P-glycoprotein using ATPase in MDR1 membranes ChEMBL. 12699389
Activity (functional) = 33 nM/mg*min Inhibition of P-glycoprotein using ATPase in MDR1 membranes ChEMBL. 12699389
CL (ADMET) = 0.5 ml/min.kg Hepatic clearance in human ChEMBL. 20070106
CL (ADMET) = 3.1 ml/min.kg Total body clearance in human ChEMBL. 19445515
CL (ADMET) = 3.1 ml/min.kg Total clearance in human ChEMBL. 20070106
CL_renal (ADMET) = 2.6 ml/min.kg Renal clearance in human ChEMBL. 20070106
CL_renal (ADMET) = 2.64 ml/min.kg Renal clearance in human ChEMBL. 19445515
EC50 (functional) = 0.0005 uM Effect on cell growth in A549 cells by colony-forming assay ChEMBL. 16279766
EC50 (functional) = 0.0005 uM Effect on cell growth in A549 cells by colony-forming assay ChEMBL. 16279766
EC50 (functional) = 0.0009 uM Effect on cell growth in A549 cells by MTS assay ChEMBL. 16279766
EC50 (functional) = 0.0009 uM Effect on cell growth in A549 cells by MTS assay ChEMBL. 16279766
EC50 (functional) = 0.001 uM Cytotoxicity against human K562 cells ChEMBL. 16870428
EC50 (functional) = 0.002 uM Cytotoxicity against human HT29 cells ChEMBL. 16870428
EC50 (functional) = 0.003 uM Cytotoxicity against human MCF7 cells ChEMBL. 16870428
EC50 (functional) = 0.025 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs ChEMBL. 15566300
EC50 (functional) = 0.025 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs ChEMBL. 15566300
EC50 (functional) = 0.026 uM Induction of apoptosis in human SNU398 cells measured after 48 hrs by cell and caspase based HTS assay ChEMBL. 19467598
EC50 (functional) = 0.026 uM Induction of apoptosis in human SNU398 cells assessed as caspase activation after 48 hrs by HTS assay ChEMBL. 20034792
EC50 (functional) = 0.032 uM Induction of apoptosis in human T47D cells measured after 48 hrs by cell and caspase based HTS assay ChEMBL. 19467598
EC50 (functional) = 0.032 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs ChEMBL. 19500976
EC50 (functional) = 0.032 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 48 hrs by HTS assay ChEMBL. 20034792
EC50 (functional) = 0.036 uM Induction of apoptosis in human HCT116 cells measured after 48 hrs by cell and caspase based HTS assay ChEMBL. 19467598
EC50 (functional) = 0.036 uM Induction of apoptosis in human HCT116 cells assessed as caspase activation after 48 hrs by HTS assay ChEMBL. 20034792
EC50 (functional) = 0.038 uM Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.038 uM Induction of apoptosis in human SNU398 cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.043 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.043 uM Induction of apoptosis in human T47D cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.044 uM Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.044 uM Induction of apoptosis in human HCT116 cells assessed as caspase activation after 24 hrs by HTS assay ChEMBL. 18197614
EC50 (functional) = 0.073 uM Induction of apoptosis in human H1299 cells assessed as caspase activation after 24 hrs ChEMBL. 15566300
EC50 (functional) = 0.129 uM Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs ChEMBL. 15566300
EC50 (functional) = 0.129 uM Induction of apoptosis in human DLD1 cells assessed as caspase activation after 24 hrs ChEMBL. 15566300
EC50 (functional) = 0.16 uM Induction of apoptosis in human DLD1 cells assessed as caspase activation after 48 hrs ChEMBL. 19500976
EC50 (binding) = 0.2 uM Inhibition of tubulin polymerization ChEMBL. 16279766
EC50 (binding) = 0.2 uM Inhibition of tubulin polymerization ChEMBL. 16279766
EC50 (functional) = 14.6 uM TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-P388 cells ChEMBL. 8862725
EC50 (functional) = 34 uM TP_TRANSPORTER: increase in Calcein-AM intracellular accumulation (Calcein-AM: 0.25 uM) in MDR-CEM cells ChEMBL. 8862725
ED (functional) = 0.0015 ug ml-1 In vitro antimitotic activity against HeLa cells after 6 hours exposure ChEMBL. 2362275
ED50 (functional) = 0.1 10'-4 ug/ml Cytotoxicity against human KB cells ChEMBL. 12828457
ED50 (functional) = 0.1 10'-4 ug/ml Cytotoxicity against human KB cells ChEMBL. 10346951
ED50 (functional) = 0.001 ug ml-1 Cytotoxicity against human Hep2 cells after 72 hrs by SRB method ChEMBL. 16643033
ED50 (functional) = 0.002 ug ml-1 Cytotoxicity against human KB cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.002 ug ml-1 Cytotoxicity against human KB cells ChEMBL. 8496701
ED50 (functional) = 0.01 ug ml-1 Cytotoxicity against human Col2 cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.01 ug ml-1 Cytotoxicity against human SK-MEL-2 cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.02 ug ml-1 Cytotoxicity against human HT cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.02 ug ml-1 Cytotoxicity against human Lu1 cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.02 ug ml-1 Cytotoxicity against mouse P388 cells after 48 hrs by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.05 ug ml-1 Cytotoxicity against human A431 cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.05 ug ml-1 Cytotoxicity against human KB cells after 72 hrs by SRB method ChEMBL. 16643033
ED50 (functional) = 0.1 ug ml-1 Cytotoxicity against human LNCAP cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 0.3 ug ml-1 Cytotoxicity against human ZR-75-1 cells by SRB assay ChEMBL. 7853002
ED50 (functional) = 1.7 ug ml-1 Cytotoxicity against mouse P388 cells ChEMBL. 7264682
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human HeLa cells after 72 hrs ChEMBL. 18500841
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human Hep2 cells after 72 hrs ChEMBL. 18500841
ED50 (functional) > 20 ug ml-1 Cytotoxicity against human KB cells after 72 hrs ChEMBL. 18500841
Fabs (ADMET) = 5 % Fraction absorbed in human ChEMBL. 21051535
GI (functional) = 84 % Growth inhibition of Mus musculus (mouse) P388 cells at 0.63 ug/ml after 24 hr by MTT assay ChEMBL. 15187442
GI50 (functional) 0 Growth inhibition of human HCT116 cells after 48 hrs ChEMBL. 18197614
GI50 (functional) 0 Growth inhibition of human SNU398 cells after 48 hrs ChEMBL. 18197614
GI50 (functional) = 1 ng ml-1 In vitro cytotoxic activity (growth inhibition) of compound against HCT 116 cancer cell line was determined ChEMBL. 12372531
GI50 (functional) = 0.4 nM Cytotoxicity against human MCF7 cells ChEMBL. 19147348
GI50 (functional) = 0.9 nM Cytotoxicity against human HeLa cells ChEMBL. 19147348
GI50 (functional) = 2.3 nM Compound was tested in vitro for growth inhibition of MCF-7 cells derived from human breast tumor. ChEMBL. 9873597
GI50 (functional) = 4.1 nM Compound was tested in vitro for growth inhibition of murine leukemic P388 cells ChEMBL. 9873597
GI50 (functional) = 5.2 nM Growth inhibition of human PC3 cells after 72 hrs by Alamar Blue assay ChEMBL. 23956835
GI50 (functional) = 350 nM Compound was tested in vitro for growth inhibition of MCF-7/ADR cells that exhibit MDR phenotype. ChEMBL. 9873597
GI50 (functional) = 470 nM Compound was tested in vitro for growth inhibition of murine leukemic P388/ADR cells that exhibit MDR phenotype. ChEMBL. 9873597
GI50 (functional) = 0.000003 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line RPMI8226 ChEMBL. 11858989
GI50 (functional) = 0.00002 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line CCRF-CEM ChEMBL. 11858989
GI50 (functional) = 0.000036 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line HL60 ChEMBL. 11858989
GI50 (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line MOLT-4 ChEMBL. 11858989
GI50 (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line HuT78 ChEMBL. 11858989
GI50 (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of human leukemic cell line K562 ChEMBL. 11858989
GI50 (functional) = 0.00025 uM Cytotoxicity against human MDA-MB-435 cells ChEMBL. 25768706
GI50 (functional) = 0.002 uM Growth inhibition of human HT29 cells after 48 hrs ChEMBL. 17498960
GI50 (functional) = 0.002 uM Growth inhibition of human MCF7 cells after 48 hrs ChEMBL. 17498960
GI50 (functional) = 0.002 uM Growth inhibition of human HT29 cells after 48 hrs by sulforhodamine B assay ChEMBL. 18579387
GI50 (functional) = 0.002 uM Growth inhibition of human MCF7 cells after 48 hrs by sulforhodamine B assay ChEMBL. 18579387
GI50 (functional) = 0.004 uM Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 25317694
GI50 (functional) = 0.005 uM Growth inhibition of human SNU398 cells after 48 hrs ChEMBL. 19467598
GI50 (functional) = 0.005 uM Growth inhibition of human SNU398 cells after 48 hrs ChEMBL. 20034792
GI50 (functional) = 0.007 uM Growth inhibition of human T47D cells after 48 hrs ChEMBL. 18197614
GI50 (functional) = 0.007 uM Growth inhibition of human T47D cells after 48 hrs ChEMBL. 18197614
GI50 (functional) = 0.007 uM Growth inhibition of human T47D cells after 48 hrs ChEMBL. 19282188
GI50 (functional) = 0.007 uM Growth inhibition of human T47D cells after 48 hrs ChEMBL. 19467598
GI50 (functional) = 0.007 uM Growth inhibition of human T47D cells after 48 hrs ChEMBL. 20034792
GI50 (functional) = 0.01 uM Growth inhibition of human M21 cells after 48 hrs ChEMBL. 17498960
GI50 (functional) < 0.01 uM Cytotoxicity against human DLD1 cells after 48 hrs by SRB assay ChEMBL. 16180824
GI50 (functional) < 0.01 uM Cytotoxicity against human SF268 cells after 48 hrs by SRB assay ChEMBL. 16180824
GI50 (functional) < 0.01 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 16180824
GI50 (functional) < 0.01 uM Cytotoxicity against human H460 cells after 48 hrs by SRB assay ChEMBL. 16180824
GI50 (functional) < 0.01 uM Cytotoxicity against human OVCAR-3 cells after 48 hrs by SRB assay ChEMBL. 16180824
GI50 (functional) = 0.01 uM Growth inhibition of human M21 cells after 48 hrs by sulforhodamine B assay ChEMBL. 18579387
GI50 (functional) = 0.01 uM Growth inhibition of human HCT116 cells after 48 hrs ChEMBL. 19467598
GI50 (functional) < 0.01 uM Growth inhibition of human Jurkat cells after 72 hrs by XTT assay ChEMBL. 19705846
GI50 (functional) = 0.01 uM Growth inhibition of human HCT116 cells after 48 hrs ChEMBL. 20034792
GI50 (functional) < 0.01 uM Cytotoxicity against human H460 cells after 48 hrs by SRB assay ChEMBL. 20112996
GI50 (functional) < 0.01 uM Cytotoxicity against human SF268 cells after 48 hrs by SRB assay ChEMBL. 20112996
GI50 (functional) < 0.01 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 20112996
GI50 (functional) = 0.06 uM Growth inhibition of human HeLa cells after 72 hrs by XTT assay ChEMBL. 19705846
GI50 (functional) = 0.3 uM Growth inhibition of human K562 cells after 72 hrs by XTT assay ChEMBL. 19705846
GI50 (functional) = 10 uM Growth inhibition of human MCF7 cells after 72 hrs by XTT assay ChEMBL. 19705846
IC50 (functional) = -7.21 Cytotoxicity against human A2780 cells after 72 hrs by MTT assay ChEMBL. 17890094
IC50 (binding) = -5 Inhibition of P-glycoprotein by Hoechst assay ChEMBL. 17890094
IC50 (binding) = -4.98 Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay ChEMBL. 17890094
IC50 (binding) = 2.06 Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assay ChEMBL. 17890094
IC50 (functional) 0 Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM verapamil by ELISA ChEMBL. 17154505
IC50 (functional) 0 Cytotoxicity against human Jurkat cells by MTS assay after 24 hrs ChEMBL. 17887662
IC50 (functional) 0 Cytotoxicity against human MCF7 cells by MTS assay after 24 hrs ChEMBL. 17887662
IC50 (ADMET) = 4.9 10'-2microM Growth inhibition of HUVEC cells after 20 hrs by MTT assay ChEMBL. 21145750
IC50 (functional) = 18 10'-3 ug/ml Cytotoxicity against mouse L929 cells after 5 days by MTT assay ChEMBL. 21456549
IC50 (functional) = 2.6 10'-4microM Growth inhibition of human HepG2 cells after 72 hrs by SRB assay ChEMBL. 18512984
IC50 (functional) = 7.95 10'3nM Antimicrobial activity against Plasmodium yoelii 265 liver infected in mammalian hepatocytes after 48 hrs ChEMBL. 18212104
IC50 (functional) = 3.9 mg ml-1 Cytotoxicity against MCF-7/Adr cells. ChEMBL. 9207950
IC50 (functional) = 0.039 nM Antiproliferative activity against human SKOV3 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.039 nM Antiproliferative activity against human SKOV3 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.063 nM Antiproliferative activity against human DU145 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.063 nM Antiproliferative activity against human DU145 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.07 nM Growth inhibition of human HepG2 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (functional) = 0.07 nM Growth inhibition of human HepG2 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (functional) = 0.099 nM Antiproliferative activity against human HT1080 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.099 nM Antiproliferative activity against human HT1080 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.11 nM Growth inhibition of human KB3-1 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (functional) = 0.12 nM Antiproliferative activity against human MDA-MB-231 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.12 nM Antiproliferative activity against human MDA-MB-231 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.16 nM Antiproliferative activity against mouse L1210 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.16 nM Antiproliferative activity against mouse L1210 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.27 nM Antiproliferative activity against human MDA-MB-435 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.27 nM Antiproliferative activity against human MDA-MB-435 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.29 nM Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM verapamil by ELISA ChEMBL. 17154505
IC50 (functional) = 0.29 nM Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM verapamil by ELISA ChEMBL. 17154505
IC50 (functional) = 0.31 nM Antiproliferative activity against MDR-1 overexpressing human 786-0 cells in presence of MDR1 inhibitor verapamil ChEMBL. 21774499
IC50 (functional) = 0.34 nM Antiproliferative activity against ChEMBL. 17154505
IC50 (functional) = 0.34 nM Antiproliferative activity against ChEMBL. 17154505
IC50 (functional) = 0.36 nM Antiproliferative activity against human K562 cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.36 nM Antiproliferative activity against human K562 after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.38 nM Antiproliferative activity against human CEM cells after 48 hrs by sulforhodamine B assay ChEMBL. 21604746
IC50 (functional) = 0.38 nM Antiproliferative activity against human CEM after 48 hrs by SRB assay ChEMBL. 21920638
IC50 (functional) = 0.4 nM Cytotoxicity against human MDA-MB-435 cells assessed as growth inhibition after 48 hrs by SRB assay ChEMBL. 23547728
IC50 (functional) = 0.42 nM Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA ChEMBL. 17154505
IC50 (functional) = 0.42 nM Antiproliferative activity against multidrug resistant MDA435/LCC6 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA ChEMBL. 17154505
IC50 (functional) = 0.49 nM Antiproliferative activity against human U937 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.49 nM Antiproliferative activity against human U937 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.49 nM Cytotoxicity against human MDA-MB-435 cells assessed as cell viability after 72 hrs by commercial absorbance assay ChEMBL. 25782063
IC50 (functional) = 0.53 nM Antiproliferative activity against human HT29 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.53 nM Antiproliferative activity against human HT29 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 0.6 nM Cytotoxicity against mouse P388 cells ChEMBL. 18651728
IC50 (functional) = 0.7 nM Antiproliferative activity against mouse P388 cells after 48 hrs by MTT assay ChEMBL. 2778449
IC50 (functional) = 0.73 nM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 18450456
IC50 (functional) = 0.79 nM Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay ChEMBL. 21106374
IC50 (functional) = 0.8 nM Cytotoxicity against human KB cells after 72 hrs by MTS assay ChEMBL. 19655762
IC50 (functional) = 0.8 nM Cytotoxicity against human KB cells after 72 hrs by MTS assay ChEMBL. 21142180
IC50 (functional) = 0.8 nM Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 22578111
IC50 (functional) = 0.8 nM Antiproliferative activity against human CEM cells after 72 hrs by MTT assay ChEMBL. 23117171
IC50 (functional) = 0.88 nM Growth inhibition of human K562 cells after 72 hrs by SRB assay ChEMBL. 18313307
IC50 (functional) = 0.88 nM Growth inhibition of human K562 cells after 72 hrs by SRB assay ChEMBL. 18313307
IC50 (functional) = 1 nM Cytotoxicity against human HL60 cells after 72 hrs by MTS assay ChEMBL. 19655762
IC50 (functional) = 1 nM Cytotoxicity against human HL60 cells after 72 hrs by MTT assay ChEMBL. 21106374
IC50 (functional) = 1 nM Growth inhibition of human CEM cells after 72 hrs by MTT assay ChEMBL. 25025853
IC50 (functional) = 1.11 nM Cytotoxicity against human HL60 cells after 72 hrs by MTS assay ChEMBL. 21142180
IC50 (functional) = 1.3 nM Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay ChEMBL. 19655762
IC50 (functional) = 1.3 nM Cytotoxicity against human CCRF-CEM cells assessed as growth inhibition after 72 hrs by Alamar Blue assay ChEMBL. 24583355
IC50 (functional) = 1.38 nM Antiproliferative activity against human HS22T1 cells after 96 hrs by CellTiter-Glo luminescent cell viability assay ChEMBL. 18177014
IC50 (functional) = 1.42 nM Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay ChEMBL. 21142180
IC50 (functional) = 1.42 nM Cytotoxicity against human HCT116 cells incubated for 72 hrs by MTS assay ChEMBL. 23072299
IC50 (functional) = 1.6 nM Antiproliferative activity against drug sensitive NCI-H69 cell line by AlamarBlue assay ChEMBL. 17286393
IC50 (functional) = 1.6 nM Cytotoxicity against human HL60 cells after 48 hrs by MTT assay ChEMBL. 19711971
IC50 (functional) = 1.8 nM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 18450456
IC50 (functional) = 2 nM Antiplasmodial activity against Plasmodium falciparum 3D7 infected in RBCs by firefly luciferase reporter gene assay ChEMBL. 20547797
IC50 (functional) = 2 nM Cytotoxicity against human CEM cells after 72 hrs by MTT assay ChEMBL. 23445496
IC50 (functional) = 2.7 nM Cytotoxicity against human SKOV3 cells after 72 hrs by MTS assay ChEMBL. 21142180
IC50 (functional) = 2.8 nM Growth inhibition of Pgp deficient MCF7 cells expressing MRP1 ChEMBL. 17567121
IC50 (functional) = 2.8 nM Growth inhibition of Pgp deficient MCF7 cells expressing MRP1 ChEMBL. 17567121
IC50 (functional) = 2.9 nM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 18450456
IC50 (functional) = 3 nM Growth inhibition of Pgp deficient MCF7/VP cells expressing MRP1 ChEMBL. 17567121
IC50 (functional) = 3.15 nM Tested for the inhibition of L1210 cell proliferation. ChEMBL. 2066973
IC50 (functional) = 3.15 nM Tested for the inhibition of L1210 cell proliferation. ChEMBL. 2066973
IC50 (functional) = 3.4 nM Antiproliferative activity against the human non small cell lung carcinoma cell line NCI-H460 ChEMBL. 11814821
IC50 (functional) = 3.5 nM Antiproliferative activity against human HCT116 cells after 72 hrs ChEMBL. 24871162
IC50 (functional) = 3.5 nM Cytotoxicity against human HCT116 cells after 72 hrs by resazurin assay ChEMBL. 23822556
IC50 (functional) = 3.9 nM Anticancer activity against human OVCAR8 cells after 96 hrs by SRB assay ChEMBL. 21557538
IC50 (functional) = 4 nM Antiproliferative activity against human HT-29 cells after 96 hrs by MTT assay ChEMBL. 2778449
IC50 (functional) = 4.1 nM Antiproliferative activity against P388 cells by ELISA ChEMBL. 17154505
IC50 (functional) = 4.1 nM Antiproliferative activity against P388 cells by ELISA ChEMBL. 17154505
IC50 (functional) = 4.1 nM Antiproliferative activity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 21663319
IC50 (functional) = 4.3 nM Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA ChEMBL. 17154505
IC50 (functional) = 4.3 nM Antiproliferative activity against adriamycin resistant P388 cells in presence of 5 uM 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane by ELISA ChEMBL. 17154505
IC50 (functional) = 4.4 nM Antiproliferative activity against multidrug resistant ChEMBL. 17154505
IC50 (functional) = 4.4 nM Antiproliferative activity against multidrug resistant ChEMBL. 17154505
IC50 (functional) = 4.5 nM Antiproliferative activity against MDR-1 overexpressing human 786-0 cells ChEMBL. 21774499
IC50 (functional) = 4.6 nM Cytotoxicity against human MCF7 cells after 72 hrs by MTS assay ChEMBL. 19655762
IC50 (functional) = 5.5 nM Cytotoxicity against human PC3 cells after 72 hrs by MTS assay ChEMBL. 21142180
IC50 (functional) = 6 nM Cytotoxicity against mouse L1210 cells after 72 hrs ChEMBL. 20932748
IC50 (functional) = 6 nM Growth inhibition of mouse L1210 cells after 72 hrs by phosphatase assay ChEMBL. 24223237
IC50 (functional) = 6 nM Cytotoxicity against mouse L1210 cells ChEMBL. 22247789
IC50 (functional) = 6 nM Cytotoxicity against mouse L1210 cells assessed as growth inhibition after 72 hrs by phosphatase assay ChEMBL. 23252481
IC50 (functional) = 6.8 nM Cytotoxicity against human HCT116 cells after 72 hrs ChEMBL. 20932748
IC50 (functional) = 10 nM Cytotoxicity against human HCT15 cells after 72 hrs by MTS assay ChEMBL. 19655762
IC50 (functional) = 10 nM Cytotoxicity against human K562 cells assessed as inhibition of cell proliferation after 72 hrs ChEMBL. 25804719
IC50 (functional) = 10.9 nM Cytotoxicity against human MCF7 cells after 72 hrs by SRB assay ChEMBL. 24074257
IC50 (functional) = 11 nM Cytotoxicity against human MDA-MB-435 cells after 48 hrs by sulforhodamine B assay ChEMBL. 20919720
IC50 (functional) = 15 nM Growth inhibition of human OVCAR8 cells overexpressing P-glycoprotein after 96 hrs ChEMBL. 22044164
IC50 (functional) = 15 nM Cytotoxicity against human OVCAR8 cells assessed as growth inhibition after 48 hrs by SRB assay ChEMBL. 26132075
IC50 (functional) = 17 nM Cytotoxicity against human A549 cells after 72 hrs by MTT assay ChEMBL. 21106374
IC50 (functional) = 25 nM Antiproliferative activity against drug resistant ACHN cell line expressing MDR1 by AlamarBlue assay ChEMBL. 17286393
IC50 (functional) = 27 nM Cytotoxicity against adriamycin-resistant mouse P388 cells expressing p-glycoprotein ChEMBL. 18651728
IC50 (functional) = 27 nM Cytotoxicity against human HCT116 cells after 72 hrs by MTT assay ChEMBL. 21106374
IC50 (functional) = 27.5 nM Resistance index, ratio of IC50 for human multidrug-resistant MDA-MB-435/LCCMDR1 cells to IC50 for human MDA-MB-435 cells ChEMBL. 20919720
IC50 (functional) = 28.5 nM Antiproliferative activity against human HCT15 cells assessed as growth inhibition ChEMBL. 21324686
IC50 (functional) = 28.5 nM Cytotoxicity against human HCT15 cells ChEMBL. 21324692
IC50 (functional) = 43 nM Antiproliferative activity against the MDR positive human colon adenocarcinoma cell line HCT-15 ChEMBL. 11814821
IC50 (functional) = 52.5 nM Cytotoxicity against human RD cells assessed as growth inhibition after 48 hrs by MTT method ChEMBL. 25025991
IC50 (functional) = 78 nM Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 18450456
IC50 (functional) = 79.4 nM Antiproliferative activity against drug resistant HCT15 cell line expressing MDR1 by AlamarBlue assay ChEMBL. 17286393
IC50 (functional) = 94 nM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei brucei 427 after 3 days by Alamar Blue assay ChEMBL. 23927763
IC50 (functional) = 95 nM Antiproliferative activity against adriamycin resistant P388 cells by ELISA ChEMBL. 17154505
IC50 (functional) = 95 nM Antiproliferative activity against adriamycin resistant P388 cells by ELISA ChEMBL. 17154505
IC50 (functional) > 110 nM Growth inhibition of vinblastine-resistant human HCT116/VM46 cells overexpressing P-gp after 72 hrs by MTS assay ChEMBL. 24223237
IC50 (functional) = 200 nM Cytotoxicity against human NCI/ADR-RES cells assessed as growth inhibition by trypan blue exclusion assay ChEMBL. 23214452
IC50 (binding) = 300 nM Inhibition of tubulin polymerization ChEMBL. 15566300
IC50 (binding) = 300 nM Inhibition of tubulin polymerization ChEMBL. 15566300
IC50 (functional) > 375 nM Growth inhibition of NCI/ADR cells expressing Pgp/MRP1 ChEMBL. 17567121
IC50 (functional) = 496 nM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 18450456
IC50 (functional) = 582 nM Anticancer activity against P-gp overexpressing human NCI/ADR-RES cells after 96 hrs by SRB assay ChEMBL. 21557538
IC50 (functional) = 600 nM Cytotoxicity against vinblastine-resistant human HCT116 cells after 72 hrs ChEMBL. 20932748
IC50 (functional) = 600 nM Cytotoxicity against human vinblastin-resistant HCT116/VM46 cells ChEMBL. 22247789
IC50 (functional) = 600 nM Cytotoxicity against human vinblastine-resistant HCT116/VM46 cells assessed as growth inhibition after 72 hrs by phosphatase assay ChEMBL. 23252481
IC50 (functional) = 600 nM Cytotoxicity against vinblastine-resistant human HCT116/VM46 cells after 72 hrs by phosphatase assay ChEMBL. 23244701
IC50 (functional) = 7950 nM Antimalarial activity against liver stages of Plasmodium yoelii yoelii ChEMBL. 22122518
IC50 (functional) = 0.02 ug ml-1 Cytotoxicity against human MCF7 cells by MTT assay ChEMBL. 16480866
IC50 (functional) = 0.025 ug ml-1 Cytotoxicity against human PA1 cells by MTT assay ChEMBL. 16480866
IC50 (functional) = 0.03 ug ml-1 Cytotoxicity against human CCRF-CEM cells ChEMBL. 9392881
IC50 (functional) = 0.046 ug ml-1 Cytotoxicity against human KB cells by MTT assay ChEMBL. 16480866
IC50 (functional) = 0.1 ug ml-1 Inhibition against CRFF-CEM-T-Cell leukemic cell line ChEMBL. 2769688
IC50 (functional) = 0.22 ug ml-1 Cytotoxicity against human MCF7 cells by clonogenic assay ChEMBL. 16480866
IC50 (functional) = 0.46 ug ml-1 Cytotoxicity against human KB cells by clonogenic assay ChEMBL. 16480866
IC50 (functional) = 0.52 ug ml-1 Cytotoxicity against human Colo320DM cells by MTT assay ChEMBL. 16480866
IC50 (functional) = 1.02 ug ml-1 Cytotoxicity against human MCF7 cells assessed as growth inhibition after 72 hrs by SRB assay ChEMBL. 25536852
IC50 (functional) = 1.08 ug ml-1 Cytotoxicity against drug-sensitive human MCF7 cells after 72 hrs by SRB assay ChEMBL. 22924480
IC50 (functional) = 1.15 ug ml-1 Cytotoxicity against human PA1 cells by clonogenic assay ChEMBL. 16480866
IC50 (functional) = 1.45 ug ml-1 Cytotoxicity against human WRL68 cells by MTT assay ChEMBL. 16480866
IC50 (functional) = 1.6 ug ml-1 Cytotoxicity against human Colo320DM cells by clonogenic assay ChEMBL. 16480866
IC50 (functional) = 2.6 ug ml-1 Cytotoxicity against human WRL68 cells by clonogenic assay ChEMBL. 16480866
IC50 (functional) = 3.6 ug ml-1 Cytotoxicity against mouse B16 cells by MTT assay ChEMBL. 11520228
IC50 (binding) > 200 ug ml-1 Inhibition of HIV1 RT ChEMBL. 1710653
IC50 (functional) = 0.0004 uM Antiproliferative activity against human CCRF-CEM cell line ChEMBL. 16759114
IC50 (functional) = 0.0004 uM Antiproliferative activity against human CCRF-CEM cell line ChEMBL. 16759114
IC50 (functional) = 0.0007 uM Antiproliferative activity against human HCT116 cell line ChEMBL. 16759114
IC50 (functional) = 0.0007 uM Antiproliferative activity against human HCT116 cell line ChEMBL. 16759114
IC50 (functional) = 0.0007 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21144756
IC50 (functional) = 0.0007 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21106377
IC50 (functional) = 0.0007 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21356592
IC50 (functional) = 0.0007 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 22507893
IC50 (functional) = 0.00073 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19124250
IC50 (functional) = 0.00073 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19576785
IC50 (functional) = 0.00073 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (ADMET) = 0.00091 uM Growth inhibition of human SKBR3 cells after 48 hrs by MTT assay ChEMBL. 22850214
IC50 (functional) = 0.001 uM Cytotoxicity against human KB cells after 72 hrs ChEMBL. 19072542
IC50 (functional) = 0.0011 uM Antiproliferative activity against human A549 cell line ChEMBL. 16759114
IC50 (functional) = 0.0011 uM Antiproliferative activity against human A549 cell line ChEMBL. 16759114
IC50 (functional) = 0.0011 uM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 19124250
IC50 (functional) = 0.0011 uM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 19576785
IC50 (functional) = 0.0012 uM Concentration required for growth inhibition of human lymphoblastic leukemic cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) = 0.0018 uM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 20181487
IC50 (functional) = 0.0018 uM Cytotoxicity against human HCT116 cells after 72 hrs by SRB assay ChEMBL. 21144756
IC50 (functional) = 0.002 uM Antiproliferative activity against human MX1 cell line ChEMBL. 16759114
IC50 (functional) = 0.002 uM Antiproliferative activity against human MX1 cell line ChEMBL. 16759114
IC50 (functional) = 0.002 uM Cytotoxicity against human CEM cells assessed as growth inhibition after 72 hrs by MTT assay ChEMBL. 24858544
IC50 (functional) = 0.0022 uM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 19124250
IC50 (functional) = 0.0022 uM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 19576785
IC50 (functional) = 0.0028 uM Cytotoxic activity against drug-sensitive Pgp-, MRP1-deficient human MCF7 cells after 48 hrs by sulforhodamine B assay in presence of 50 nM vinblastin ChEMBL. 21680190
IC50 (functional) = 0.0029 uM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 20181487
IC50 (functional) = 0.0029 uM Cytotoxicity against human MX1 cells after 72 hrs by SRB assay ChEMBL. 21144756
IC50 (functional) = 0.0029 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by AlamarBlue assay ChEMBL. 25014640
IC50 (functional) = 0.003 uM Cytotoxicity against human HCT116 cells after 72 hrs by MTS assay ChEMBL. 15043437
IC50 (functional) = 0.0037 uM Cytotoxicity against human A2058 cells assessed as growth inhibition after 96 hrs by CellTiter-Glo luminescence assay ChEMBL. 23659371
IC50 (ADMET) = 0.004 uM Cytotoxicity against drug-sensitive CCRF-CEM cells after 72 hrs ChEMBL. 17323939
IC50 (functional) = 0.004 uM Intrinsic cytotoxic activity of the compound against wild type HCT116 cell line ChEMBL. 15546712
IC50 (ADMET) = 0.004 uM Cytotoxicity against drug-sensitive CCRF-CEM cells after 72 hrs ChEMBL. 17323939
IC50 (functional) = 0.004 uM Antiproliferative activity against human CEM cells after 72 hrs by MTT assay ChEMBL. 22027100
IC50 (functional) = 0.0045 uM Cytotoxicity against human HT-29 cells assessed as reduction in cell growth incubated for 72 hrs ChEMBL. 26147490
IC50 (functional) = 0.005 uM Cytotoxicity against human A2780 cells after 72 hrs by MTS assay ChEMBL. 15043437
IC50 (functional) = 0.005 uM Cytotoxicity against human PC3 cells after 96 hrs by CellTiter-Glo assay ChEMBL. 23560689
IC50 (ADMET) = 0.008 uM Cytotoxicity against teniposide-resistant CEM/VM1 cells after 72 hrs ChEMBL. 17323939
IC50 (functional) = 0.0087 uM Concentration required for growth inhibition of human HCT-116 colon tumor cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) = 0.0094 uM Cytotoxicity against human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 22530779
IC50 (functional) = 0.0099 uM Concentration required for growth inhibition of human lung carcinoma cell line (CCRF-CEM) was determined ChEMBL. 15324894
IC50 (functional) = 0.011 uM Inhibition of the growth of MDA-MB 231 human breast cancer cells ChEMBL. 9357519
IC50 (functional) = 0.028 uM Growth inhibition of human RPMI8226 cells ChEMBL. 18164197
IC50 (functional) = 0.028 uM Growth inhibition of human RPMI8226 cells ChEMBL. 18164197
IC50 (functional) = 0.0287 uM Antiproliferative activity against human taxol resistant CCRF-CEM cell line ChEMBL. 16759114
IC50 (functional) = 0.0287 uM Antiproliferative activity against human taxol resistant CCRF-CEM cell line ChEMBL. 16759114
IC50 (functional) = 0.07 uM The compound tested for the inhibition of tubulin polymerization. ChEMBL. 2066973
IC50 (functional) = 0.07 uM The compound tested for the inhibition of tubulin polymerization. ChEMBL. 2066973
IC50 (functional) = 0.072 uM Cytotoxicity against human SKBR3 cells after 72 hrs by MTS assay ChEMBL. 15043437
IC50 (functional) = 0.078 uM Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19124250
IC50 (functional) = 0.078 uM Cytotoxicity against human vinblastine-resistant CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19576785
IC50 (functional) = 0.078 uM Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (functional) = 0.08 uM Cytotoxicity against Taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21144756
IC50 (functional) = 0.08 uM Cytotoxicity against taxol-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21106377
IC50 (functional) = 0.08 uM Cytotoxicity against human taxol-resistant CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21356592
IC50 (functional) = 0.135 uM Cytotoxicity against VM46-resistant human HCT116 cells overexpressing P-gp after 72 hrs by MTS assay ChEMBL. 15043437
IC50 (functional) = 0.17 uM Growth inhibition of doxorubicin-resistant human K562 cells after 72 hrs by SRB assay ChEMBL. 18313307
IC50 (functional) = 0.17 uM Growth inhibition of doxorubicin-resistant human K562 cells after 72 hrs by SRB assay ChEMBL. 18313307
IC50 (functional) = 0.2066 uM Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line ChEMBL. 16759114
IC50 (functional) = 0.2066 uM Antiproliferative activity against human vinblastine resistant CCRF-CEM cell line ChEMBL. 16759114
IC50 (ADMET) = 0.356 uM Cytotoxicity against vinblastine-resistant CEM/VLB100 cells after 72 hrs ChEMBL. 17323939
IC50 (functional) = 0.41 uM Antitrypanosomal activity against bloodstream form of Trypanosoma brucei 427 after 48 hrs by MTS assay ChEMBL. 22850214
IC50 (functional) = 0.44 uM Growth inhibition of doxorubicin resistant human HepG2 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (functional) = 0.44 uM Growth inhibition of doxorubicin resistant human HepG2 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (functional) = 0.496 uM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19124250
IC50 (functional) = 0.496 uM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 20181487
IC50 (functional) = 0.5 uM Cytotoxicity against human taxol-resistant CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 19576785
IC50 (functional) = 0.5 uM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21144756
IC50 (functional) = 0.5 uM Cytotoxicity against vinblastine-resistant human CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21106377
IC50 (functional) = 0.5 uM Cytotoxicity against human vinblastine-resistant CCRF-CEM cells after 72 hrs by XTT assay ChEMBL. 21356592
IC50 (functional) = 0.6 uM Concentration of compound required to inhibit tubulin polymerization (Microtubule assembly) was determined by the turbidity formation after 20 min of incubation ChEMBL. 12372531
IC50 (binding) = 0.6 uM Inhibition of bovine tubulin polymerization by turbidity assay ChEMBL. 25768706
IC50 (functional) = 0.7 uM Inhibition of tubulin polymerization using isolated calf brain ChEMBL. 9357519
IC50 (binding) = 0.95 uM Inhibition of bovine neuronal tubulin polymerization for 20 mins ChEMBL. 18182300
IC50 (binding) = 1 uM Inhibition of tubulin polymerization (unknown origin) ChEMBL. 18164197
IC50 (functional) = 1 uM Inhibition of tubulin polymerization interacting at the colchicine binding site. ChEMBL. 15686910
IC50 (ADMET) > 1 uM Cytotoxicity against human IMR90 cells after 96 hrs by CellTiter-Glo luminescent assay ChEMBL. 23368996
IC50 (functional) = 1.04 uM Growth inhibition of human KB V1 cells after 72 hrs by MTT assay ChEMBL. 18313307
IC50 (binding) = 1.6 uM Inhibition of porcine brain tubulin polymerization by microtubule assembly assay ChEMBL. 21106374
IC50 (binding) = 1.66 uM Inhibition of bovine neuronal tubulin polymerization for 60 mins ChEMBL. 18182300
IC50 (functional) = 2 uM Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC ChEMBL. 12699389
IC50 (functional) = 2 uM Inhibition of P-glycoprotein using calcein-AM assay transfected in porcine PBCEC ChEMBL. 12699389
IC50 (binding) = 2.1 uM Inhibition of tubulin (unknown origin) polymerization ChEMBL. 25804719
IC50 (functional) = 3 uM Inhibitory concentration of the compound against K562 cell line ChEMBL. 15369401
IC50 (functional) = 6.88 uM Cytotoxicity against human U937 cells by MTS assay after 24 hrs ChEMBL. 17887662
IC50 (functional) = 6.88 uM Cytotoxicity against human U937 cells by MTS assay after 24 hrs ChEMBL. 17887662
IC50 (functional) = 8 uM Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) = 8 uM Inhibition of P-glycoprotein, mouse L-mdr1b expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) = 8 uM TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1b-expressing LLC-PK1 cells ChEMBL. 12699389
IC50 (functional) = 17.7 uM TP_TRANSPORTER: inhibition of Daunorubicin efflux in NIH-3T3-G185 cells ChEMBL. 11716514
IC50 (functional) = 19.9 uM TP_TRANSPORTER: inhibition of LDS-751 efflux in NIH-3T3-G185 cells ChEMBL. 11716514
IC50 (functional) = 21 uM TP_TRANSPORTER: inhibition of calcein-AM efflux in MRP2-expressing MDCK cells ChEMBL. 15616150
IC50 (ADMET) = 26 uM Inhibition of human cytochrome P450 3A4 ChEMBL. 12699389
IC50 (ADMET) = 26 uM Inhibition of human cytochrome P450 3A4 ChEMBL. 12699389
IC50 (functional) = 29 uM TP_TRANSPORTER: inhibition of calcein-AM efflux in MDR1-expressing MDCK cells ChEMBL. 15616150
IC50 (functional) = 29.5 uM TP_TRANSPORTER: inhibition of Rhodamine 123 efflux in NIH-3T3-G185 cells ChEMBL. 11716514
IC50 (functional) = 30 uM TP_TRANSPORTER: inhibition of E217betaG uptake (E217betaG: 0.05 uM) in membrane vesicle from MRP1-expressing HeLa cells ChEMBL. 8621644
IC50 (binding) = 34 uM Concentration required for 50% inhibition of the compound at binding site of human P-Glycoprotein (P-gp) in one-affinity model ChEMBL. 12477351
IC50 (ADMET) = 43.5 uM Inhibition of human OATP1B3-mediated [3H]CCK-8 after 5 mins by Dixon plot method ChEMBL. 25618019
IC50 (ADMET) = 46.8 uM Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at after 5 mins by Dixon plot method ChEMBL. 25618019
IC50 (functional) > 50 uM Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) > 50 uM Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) > 50 uM Inhibition of P-glycoprotein, mouse L-mdr1a expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) > 50 uM Inhibition of P-glycoprotein, human L-MDR1 expressed in LLC-PK1 epithelial cells using calcein-AM polarisation assay ChEMBL. 12699389
IC50 (functional) > 50 uM TP_TRANSPORTER: inhibition of Calcein-AM efflux in MDR1-expressing LLC-PK1 cells ChEMBL. 12699389
IC50 (functional) > 50 uM TP_TRANSPORTER: inhibition of Calcein-AM efflux in Mdr1a-expressing LLC-PK1 cells ChEMBL. 12699389
IC50 (functional) = 62 uM TP_TRANSPORTER: increase in dihydrofluorescein intracellular accumulation (dihydrofluorescein: 1 uM) in SK-E2 cells (expressing BSEP) ChEMBL. 12739759
IC50 (functional) = 114.7 uM TP_TRANSPORTER: increase in bodipy intracellular accumulation (Bodipy: 0.2 uM) in SK-E2 cells (expressing BSEP) ChEMBL. 12739759
IC50 (functional) = 193 uM Resistant ratio, IC50 for multidrug resistant human K562 cells to IC50 for human K562 cells ChEMBL. 18313307
IC50 (functional) = 193 uM Resistant ratio, IC50 for multidrug resistant human K562 cells to IC50 for human K562 cells ChEMBL. 18313307
IC50 (functional) = 5946 uM Resistant ratio, IC50 for multidrug resistant human HepG2 cells to IC50 for human HepG2 cells ChEMBL. 18313307
IC50 (functional) = 5946 uM Resistant ratio, IC50 for multidrug resistant human HepG2 cells to IC50 for human HepG2 cells ChEMBL. 18313307
IC50 (functional) = 9271 uM Resistant ratio, IC50 for multidrug resistant human KB3-1 cells to IC50 for human KB3-1 cells ChEMBL. 18313307
IC50 (binding) = 1.1 umol/L Inhibition of porcine brain tubulin polymerization assessed as microtubule assembly after 15 mins by DAPI staining ChEMBL. 26204510
ILS (functional) = 0 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intraperitoneally at a dose of 4 mg/kg per day ChEMBL. 4020828
ILS (functional) = 14.6 % Evaluation of Survival of mice upon intraperitoneal injection of VBL at a concentration of 0.2 mg/kg ChEMBL. 8544183
ILS (functional) = 21.6 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 9 mg/kg per day ChEMBL. 4020828
ILS (functional) = 24.7 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 6 mg/kg per day ChEMBL. 4020828
ILS (functional) = 30.3 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 3 mg/kg per day ChEMBL. 4020828
ILS (functional) = 30.8 % Percent increase in life span at dose 3 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 31.9 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 4 mg/kg per day ChEMBL. 4020828
ILS (functional) = 35 % Percent increase in life span at dose 4 mg/kg/day in 7 mice implanted with P388 leukemia cell line for 1,8,15 scheduled day from Exp-2 ChEMBL. 4020828
ILS (functional) = 35 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 7 mg/kg per day ChEMBL. 4020828
ILS (functional) = 37 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 5 mg/kg per day ChEMBL. 4020828
ILS (functional) = 40 % Percent increase in life span at dose 11 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 42.3 % Percent increase in life span at dose 4 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 47.1 % Percent increase in life span at dose 5 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 48 % Percent increase in life span at dose 6 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 49.5 % Percent increase in life span at dose 9 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 52 % Percent increase in life span at dose 4 mg/kg/day in 10 mice implanted with P388 leukemia cell line for 1st scheduled day ChEMBL. 4020828
ILS (functional) = 54 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intraperitoneally at a dose of 2 mg/kg per day ChEMBL. 4020828
ILS (functional) = 57.6 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intravenouslly at a dose of 8 mg/kg per day ChEMBL. 4020828
ILS (functional) = 58 % Percent increase in life span at dose 4 mg/kg/day in 7 mice implanted with P388 leukemia cell line for 1,8,15 scheduled day from Exp-1 ChEMBL. 4020828
ILS (functional) = 59.3 % Percent increase in life span at dose 7 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 61 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intraperitoneally at a dose of 6 mg/kg per day ChEMBL. 4020828
ILS (functional) = 63 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia intraperitoneally at a dose of 3 mg/kg per day ChEMBL. 4020828
ILS (functional) = 72.9 % Percent increase in life span at dose 8 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 74 % Percent increase in life span of DBA2 mice after inoculation with L1210 leukemia cells intraperitoneally at a dose of 0.33 mg/kg per day for 1-9 scheduled days ChEMBL. 4020828
ILS (functional) = 81 % Percent increase in life span at dose 10 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
ILS (functional) = 89 % Evaluation of ILS percentage of mice upon intraperitoneal injection of VBL at a concentration of 0.2 mg/kg ChEMBL. 8544183
ILS (functional) = 112 % Percent increase in life span at dose 4 mg/kg/day in 10 mice implanted with P388 leukemia cell line ChEMBL. 4020828
Inhibition (binding) Inhibition of tubulin polymerization in human NCI-H522 cells assessed as beta-tubulin accumulation in cytoskeletal fraction at 100 nM after 24 hrs by Western blot analysis ChEMBL. 23916255
Inhibition (binding) Inhibition of tubulin polymerization in human NCI-H522 cells assessed as alpha-tubulin accumulation in cytoskeletal fraction at 100 nM after 24 hrs by Western blot analysis ChEMBL. 23916255
Inhibition (binding) Inhibition of tubulin polymerization (unknown origin) after 90 mins ChEMBL. 23708010
Inhibition (binding) Inhibition of tubulin polymerization (unknown origin) at 5 uM after 1 hr ChEMBL. 23956835
Inhibition (binding) Displacement of colchicine from tubulin (unknown origin) preincubated for 30 mins followed by colchicine addition measured after 30 mins by fluorescence assay ChEMBL. 25815147
Inhibition (binding) Inhibition of human MDR1 expressed in MDCK cells assessed as fluorescence activity at 30 uM after 1.5 hrs by rhodamine 123 efflux test ChEMBL. 20363635
Inhibition (binding) Inhibition of pig brain tubulin polymerization at 5 uM measured every min for 60 mins by spectrophotometry ChEMBL. 22247791
Inhibition (binding) Inhibition of pig brain tubulin polymerization measured every 1 min for 40 mins by microplate reader analysis ChEMBL. 23547728
Inhibition (binding) Inhibition of porcine brain tubulin polymerization at 1 uM measured every 30 seconds for 30 mins ChEMBL. 23916255
Inhibition (ADMET) = -9.3 % Inhibition of human liver OATP2B1 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E3S uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
Inhibition (binding) = 1.9 % Inhibition of 4-(4-(dimethylamino)styryl)-N-methylpyridinium uptake at human OCT1 expressed in HEK293 cells at 100 uM by confocal microscopy ChEMBL. 18788725
Inhibition (binding) = 50 % Displacement of [3H]Vinblastine from pig tubulin at 7.2 x 10'-5 M after 60 mins ChEMBL. 23252481
Inhibition (binding) = 50 % Displacement of [3H]-vinblastine from pig tubulin at 7.2 x 10'-5 M after 60 mins ChEMBL. 23244701
Inhibition (ADMET) = 54.3 % Inhibition of human liver OATP1B3 expressed in HEK293 Flp-In cells assessed as reduction in [3H]E17-betaG uptake at 20 uM incubated for 5 mins by scintillation counting ChEMBL. 22541068
Inhibition (ADMET) = 57.6 % Inhibition of human liver OATP1B1 expressed in HEK293 Flp-In cells assessed as reduction in E17-betaG uptake at 20 uM by scintillation counting ChEMBL. 22541068
Inhibition (functional) = 64 % Inhibition of colchicine binding to tubulin ChEMBL. 9357519
Inhibition (ADMET) = 64.1 % Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at 100 uM after 5 mins relative to control ChEMBL. 25618019
Inhibition (binding) = 73.93 % Inhibition of pig tubulin polymerization at 5 uM incubated for 20 mins at 37 degC by fluorescence based tubulin polymerization inhibition assay ChEMBL. 26474666
Inhibition (functional) = 75 % Inhibition of P-gp was determined using rhodamine-assay in human CaCo-2 cells ChEMBL. 12699389
Inhibition (functional) = 75 % Inhibition of P-gp was determined using rhodamine-assay in human CaCo-2 cells ChEMBL. 12699389
Inhibition (ADMET) = 81.5 % Inhibition of human OATP1B3-mediated [3H]CCK-8 at 100 uM after 5 mins relative to control ChEMBL. 25618019
IZ (functional) = 0 cm Antifungal activity against yeast AD1-8u expressing Candida albicans CaMdr1p by agar disk diffusion assay ChEMBL. 20739103
IZ (functional) = 0.6 cm Antifungal activity against yeast AD1-8u expressing Candida albicans CaCdr1p by agar disk diffusion assay ChEMBL. 20739103
IZ (functional) = 10 mm Antiproliferative activity against human HT-29 cells at 0.01 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
IZ (functional) = 12.5 mm Antiproliferative activity against mouse P388 cells at 0.01 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
IZ (functional) = 25 mm Antiproliferative activity against human HT-29 cells at 0.1 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
IZ (functional) = 32.5 mm Antiproliferative activity against mouse P388 cells at 0.1 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
IZ (functional) = 40 mm Antiproliferative activity against human HT-29 cells at 1 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
IZ (functional) > 40 mm Antiproliferative activity against mouse P388 cells at 1 ug after 48 hrs by two-layer agar-diffusion method ChEMBL. 2778449
Kd (functional) = 3 uM TP_TRANSPORTER: binding in membrane vesicle from CEM/VLB100 cells ChEMBL. 10411602
Ki (binding) = 0.1 uM High affinity constant at binding site of human P-Glycoprotein (P-gp) in two-affinity model ChEMBL. 12477351
Ki (binding) = 1.3 uM Concentration giving half of the maximal ATPase activity calculated for the high-affinity binding site of the CHO P-Glycoprotein (P-gp) in two-affinity model ChEMBL. 12477351
Ki (functional) = 2.1 uM TP_TRANSPORTER: inhibition of ATPase activity (Verapamil) in membranes from CEM/VLB100 cells ChEMBL. 9751076
Ki (ADMET) = 10.2 uM Inhibition of human OATP1B1-mediated [3H]estrone 3-sulfate at after 5 mins by Dixon plot method ChEMBL. 25618019
Ki (functional) = 15 uM TP_TRANSPORTER: transepithelial transport of digoxin (basal to apical) in Caco-2 cells ChEMBL. 12636153
Ki (ADMET) = 18.6 uM Inhibition of human OATP1B3-mediated [3H]CCK-8 after 5 mins by Dixon plot method ChEMBL. 25618019
Ki (functional) = 36.5 uM TP_TRANSPORTER: inhibition of Taxol transepithelial transport (basal to apical) in Caco-2 cells ChEMBL. 11405287
Ki (binding) = 77 uM Inhibitory activity of the compound against Monoamine oxidase B isolated from beef liver mitochondria was determined ChEMBL. 2362262
Ki (binding) = 77 uM Inhibition of bovine liver MAOB ChEMBL. 1593278
Ki (binding) > 100 uM Binding constant at colchicine site of bovine brain tubulin ChEMBL. 11814821
Ki (functional) = 140 uM TP_TRANSPORTER: inhibition of Digoxin transepithelial transport (basal to apical) in MDR1-expressing MDCK cells ChEMBL. 12134945
Km (functional) = 0.8 uM TP_TRANSPORTER: ATP hydrolysis in reconstituted proteoliposomes ChEMBL. 8621716
Km (functional) = 5.71 uM TP_TRANSPORTER: ATP hydrolysis in membrane fraction from High Five (BTI-TN5B1-4) cells ChEMBL. 11785684
Km (functional) = 18.99 uM TP_TRANSPORTER: transepithelial transport (basal to apical) in Caco-2 cells ChEMBL. 8100632
Km (functional) = 99.4 uM TP_TRANSPORTER: intracellular accumulation in MDR1-expressing LLC-PK1 cells ChEMBL. 10617675
Km (functional) = 137.3 uM TP_TRANSPORTER: transepithelial transport (basal to apical) in the presence of PSC-833 in MRP2-expressing MDCK cells ChEMBL. 12134946
Km (functional) = 252.8 uM TP_TRANSPORTER: transepithelial transport (basal to apical) in MDR1-expressing MDCK cells ChEMBL. 12134945
LC50 (functional) < 0.00025 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell grwoth of T cell leukemia cell line MOLT-4 using MTT assay ChEMBL. 11858989
LC50 (functional) = 0.00025 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell growth of HuT78 T lymphoma using MTT assay ChEMBL. 11858989
LC50 (functional) < 0.00025 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell growth of K562 chronic myeloid leukemia using MTT assay ChEMBL. 11858989
LC50 (functional) = 0.00151 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell growth of HL60 acute myeloid leukemia using MTT assay ChEMBL. 11858989
LC50 (functional) = 0.00328 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell growth of RPMI8226 multiple myeloma using MTT assay ChEMBL. 11858989
LC50 (functional) = 0.00573 uM Tested for the concentration required to reduce the viability of leukemia cells by 50% against cell growth of T cell leukemia cell line CCRF-CEM using MTT assay ChEMBL. 11858989
LC50 (functional) = 0.92 uM Cytotoxicity against human OVCAR-3 cells after 48 hrs by SRB assay ChEMBL. 16180824
LC50 (functional) = 2.1 uM Cytotoxicity against human H460 cells after 48 hrs by SRB assay ChEMBL. 16180824
LC50 (functional) = 2.1 uM Cytotoxicity against human H460 cells after 48 hrs by SRB assay ChEMBL. 20112996
LC50 (functional) = 2.48 uM Cytotoxicity against human DLD1 cells after 48 hrs by SRB assay ChEMBL. 16180824
LC50 (functional) = 2.48 uM Cytotoxicity against human SF268 cells after 48 hrs by SRB assay ChEMBL. 16180824
LC50 (functional) = 2.48 uM Cytotoxicity against human SF268 cells after 48 hrs by SRB assay ChEMBL. 20112996
LC50 (functional) = 2.5 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 16180824
LC50 (functional) = 2.5 uM Cytotoxicity against human MCF7 cells after 48 hrs by SRB assay ChEMBL. 20112996
LD50 (ADMET) = 10 mg kg-1 Acute iv toxicity against mice after a dose of injection ChEMBL. 4020828
LD50 (ADMET) = 26 mg kg-1 Acute iv toxicity against Swiss strain of 40 mice after 4 doses of injection ChEMBL. 4020828
LD50 (ADMET) = 27.4 mg kg-1 Acute iv toxicity against NMRI strain of 100 mice after 7 doses of injection ChEMBL. 4020828
LD50 (ADMET) = 28 mg kg-1 Acute iv toxicity against CD1 strain of 40 mice after 4 doses of injection ChEMBL. 4020828
Log 1/Km (ADMET) = -0.834 log (1/Km) value for human liver microsome cytochrome P450 3A4 ChEMBL. 15990295
Log IC50 (binding) = 2.06 Inhibition of P-glycoprotein expressed in MDCK-MDR1 cells by calcein AM assay ChEMBL. 17890094
Log IC50 (binding) = 4.98 Inhibition of P-glycoprotein expressed in A2780/ADR cells by calcein AM assay ChEMBL. 17890094
Log IC50 (binding) = 5 Inhibition of P-glycoprotein by Hoechst assay ChEMBL. 17890094
Log IC50 (functional) = 5.55 Cytotoxicity against human A2780/ADR cells after 72 hrs by MTT assay ChEMBL. 17890094
Log IC50 (functional) = 7.21 Cytotoxicity against human A2780 cells after 72 hrs by MTT assay ChEMBL. 17890094
Log kill (functional) < 0.7 In vivo activity against transplanted Panc-02 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-17 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mel-B16 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-16/C/ Taxol tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-16/C/Adr tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Squam lung-LC12 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted colon-26 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Mam-17/Adr tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against iv transplanted AML Leukemia 1498 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted colon-51 tumors of mice ChEMBL. 11356111
Log kill (functional) < 0.7 In vivo activity against transplanted Panc-03 tumors of mice ChEMBL. 11356111
Log kill (functional) = 1.9 In vivo activity against iv transplanted Leukemia L1210 tumors of mice ChEMBL. 11356111
Log kill (functional) = 1.9 In vivo activity against transplanted Mam-16/C tumors of mice ChEMBL. 11356111
Log kill (functional) = 2.8 In vivo activity against transplanted colon-38 tumors of mice ChEMBL. 11356111
logP (ADMET) = 5.2 Partition coefficient (logP) ChEMBL. 12699389
LTS (functional) = 2 Long-term survivors (LTS) for 60 days at optimal dose of 3.0 mg/kg for antitumor activity against P388 leukemia cells in 45 mice. ChEMBL. 2066973
Papp (ADMET) = 5.1 nm/s Apparent permeability across human Caco-2 cells ChEMBL. 19296600
Papp (ADMET) < 10 nm/s Apparent permeability (Papp) from apical to basolateral side determined in MDR1-MDCKII cells ChEMBL. 11602674
Papp (ADMET) = 232 nm/s Apparent permeability (Papp) from basolateral to apical side determined in MDR1-MDCKII cells ChEMBL. 11602674
Permeability (functional) = 1.54 *10e6 Absorptive transport of the compound in Caco-2 cells in comparison to metoprolol ChEMBL. 10753475
Permeability (functional) = 12.5 *10e6 Secretory Transport of the compound in Caco-2 cells in comparison to metoprolol ChEMBL. 10753475
permeability (ADMET) = 0.1 10'-6 cm/s Permeability from apical to basolateral side in human Caco-2 cells ChEMBL. 17606674
permeability (ADMET) = 41.9 10'-6 cm/s Permeability from basolateral to apical side in human Caco-2 cells ChEMBL. 17606674
Ratio (functional) = 3 P-gp activity was measured by a direct transport assay, using polarized LLC-PK1 epithelialcells ChEMBL. 12699389
Ratio (functional) = 4.3 P-gp activity was measured by a direct transport assay, using polarized LLC-mdr1a epithelialcells ChEMBL. 12699389
Ratio (functional) = 5.2 P-gp activity was measured by a direct transport assay, using polarized LLC-MDR1 epithelial cells ChEMBL. 12699389
Ratio IC50 (functional) = 2 Ratio of IC50 for teniposide-resistant CEM/VM1 cells over IC50 for drug-sensitive CCRF-CEM cells ChEMBL. 17323939
Ratio IC50 (functional) = 10 Relative fold, IC50 in absence to presence of 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane in multidrug resistant MDA435/LCC6 cells ChEMBL. 17154505
Ratio IC50 (functional) = 15 Relative fold, IC50 in absence to presence of verapamil in multidrug resistant MDA435/LCC6 cells ChEMBL. 17154505
Ratio IC50 (functional) = 22 Relative fold, IC50 in absence to presence of 1,13-bis[4'-((5,7-dihydroxy)-4H-chromen-4-on-2-yl)phenyl]-1,4,7,10,13-pentaoxatridecane in multidrug resistant P388 cells ChEMBL. 17154505
Ratio IC50 (functional) = 89 Ratio of IC50 for vinblastine-resistant CEM/VLB100 cells over IC50 for drug-sensitive CCRF-CEM cells ChEMBL. 17323939
Reduction (functional) = 0 % Approximate percentage for level of inhibition of cell growth in presence and absence of inhibitor (Value of drug + GG918 / Value of drug) ChEMBL. 15012986
Reduction (functional) ~ 88 % Approximate percentage for level of inhibition of cell growth in presence and absence of inhibitor (Value of drug + Verapamil / Value of drug) ChEMBL. 15012986
Reduction (functional) ~ 94 % Percentage inhibition of cell growth in the presence of compound and in the absence of GG198 in H69/LX4 cells with clofazimine MDR inhibitor ChEMBL. 15012986
Reduction (functional) ~ 95 % Approximate percentage for level of inhibition of cell growth in presence and absence of inhibitor (Value of drug + GG918 / Value of drug) ChEMBL. 15012986
Reduction (functional) ~ 95 % Approximate percentage for level of inhibition of cell growth in presence and absence of inhibitor (Value of drug + alpha Tochoferol / Value of drug) ChEMBL. 15012986
Relative IC50 (functional) = 0.2 nM Cytotoxic activity was evaluated against P388/ADR + reserpine cells ChEMBL. 8632413
Relative IC50 (functional) = 0.5 nM Cytotoxic activity was evaluated against MCF-7/ADR+Reserpine cells ChEMBL. 8632413
Relative IC50 (functional) = 1 nM Cytotoxic activity was evaluated against KB3-1 cells ChEMBL. 8632413
Relative IC50 (functional) = 1 nM Cytotoxic activity was evaluated against MCF-7 cells ChEMBL. 8632413
Relative IC50 (functional) = 1 nM Cytotoxic Activity of the compound was evaluated against P388D1 cells ChEMBL. 8632413
Relative IC50 (functional) = 1.3 nM Cytotoxic activity was evaluated against KBV-1 cells in presence of reserpine ChEMBL. 8632413
Relative IC50 (functional) = 19 nM Cytotoxic activity was evaluated against P388D1/ADR cells ChEMBL. 8632413
Relative IC50 (functional) = 2000 nM Cytotoxic activity was evaluated against KBV-1 cells ChEMBL. 8632413
Relative IC50 (functional) = 17500 nM Cytotoxic activity was evaluated against MCF-7/ADR cells ChEMBL. 8632413
T/C (functional) = 140 % The ratio of survival time for treated divided by survival time of control x 100 at a dose of 0.2 mg/kg in L1210 leukemia cells ChEMBL. 2362275
T/C (functional) = 157 % Compound was tested for T/C range at optimal dose of 3.0 mg/kg for antitumor activity against P388 leukemia cells in mice; value ranges from 157-203 ChEMBL. 2066973
T/C (functional) = 157 % Compound was tested for T/C range at optimal dose of 3.0 mg/kg for antitumor activity against P388 leukemia cells in mice; value ranges from 157-203 ChEMBL. 2066973
T/C (functional) = 180 % The ratio of survival time for treated divided by survival time of control x 100 at a dose of 0.2 mg/kg in B16 melanoma cells ChEMBL. 2362275
T/C (functional) = 309 % Antitumor activity against mouse B16 cells xenografted in B6C3F1 mouse at 0.5 mg/kg relative to control ChEMBL. 6631435
TGI (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of Tcell leukemic cell line MOLT-4 using MTT assay ChEMBL. 11858989
TGI (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of HuT78 T lymphoma using MTT assay ChEMBL. 11858989
TGI (functional) < 0.00025 uM Tested for the inhibitory concentration against cell growth of K562 chronic myeloid leukemia using MTT assay ChEMBL. 11858989
TGI (functional) = 0.00025 uM Tested for the inhibitory concentration against cell growth of HL60 acute myeloid leukemia using MTT assay ChEMBL. 11858989
TGI (functional) = 0.0008 uM Tested for the inhibitory concentration against cell growth of RPM18226 multiple myeloma using MTT assay ChEMBL. 11858989
TGI (functional)