Detailed information for compound 6802

Basic information

Technical information
  • TDR Targets ID: 6802
  • Name: LY-139481
  • MW: 473.583 | Formula: C28H27NO4S
  • H donors: 2 H acceptors: 3 LogP: 6.09 Rotable bonds: 7 Rule of 5 violations (Lipinski): 1
  • SMILES: Oc1ccc2c(c1)sc(c2C(=O)c1ccc(cc1)OCCN1CCCCC1)c1ccc(cc1)O
  • InChi: 1S/C28H27NO4S/c30-21-8-4-20(5-9-21)28-26(24-13-10-22(31)18-25(24)34-28)27(32)19-6-11-23(12-7-19)33-17-16-29-14-2-1-3-15-29/h4-13,18,30-31H,1-3,14-17H2
  • InChiKey: GZUITABIAKMVPG-UHFFFAOYSA-N  

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Synonyms

  • RAL
  • Raloxifene
  • Raloxifene Hcl
  • Raloxifene Hydrochloride
  • Raloxifeno [Spanish]
  • Raloxifenum [Latin]
  • [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothiophen-3-yl]-[4-(2-piperidin-1-ylethoxy)phenyl]methanone
  • [6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone
  • [6-hydroxy-2-(4-hydroxyphenyl)-3-benzothiophenyl]-[4-[2-(1-piperidyl)ethoxy]phenyl]methanone
  • [6-hydroxy-2-(4-hydroxyphenyl)benzothiophen-3-yl]-[4-(2-piperidinoethoxy)phenyl]methanone
  • 84449-90-1
  • Methanone, (6-hydroxy-2-(4-hydroxyphenyl)benzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)-
  • KBioGR_002361
  • [6-hydroxy-2-(4-hydroxyphenyl)-1-benzothien-3-yl]{4-[(2-piperidin-1-ylethyl)oxy]phenyl}methanone
  • C07228
  • LY 139481
  • cMAP_000032
  • SPBio_002824
  • Lopac-R-1402
  • NCGC00015889-01
  • CAS-82640-04-8
  • NCGC00015889-02
  • Prestwick2_000862
  • KBioSS_002364
  • BPBio1_000995
  • KBio3_002840
  • Prestwick0_000862
  • Lopac0_001051
  • KBio2_002361
  • KBio2_004929
  • KBio2_007497
  • NCGC00092353-03
  • SMP2_000095
  • Prestwick1_000862
  • (2-(4-Hydroxyphenyl)-6-hydroxybenzo(b)thien-3-yl)(4-(2-(1-piperidinyl)ethoxy)phenyl)methanone
  • (6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methanone
  • nchembio.76-comp4
  • Prestwick3_000862
  • BSPBio_000903
  • CCRIS 7129
  • Keoxifene

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Estrogen receptor Starlite/ChEMBL References
Homo sapiens opioid receptor, delta 1 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 3, subfamily A, polypeptide 4 Starlite/ChEMBL References
Mus musculus aldehyde oxidase 1 Starlite/ChEMBL References
Rattus norvegicus Muscarinic acetylcholine receptor M1 Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2A Starlite/ChEMBL References
Homo sapiens nuclear receptor subfamily 1, group H, member 4 Starlite/ChEMBL References
Homo sapiens nuclear factor of kappa light polypeptide gene enhancer in B-cells 1 Starlite/ChEMBL References
Homo sapiens opioid receptor, kappa 1 Starlite/ChEMBL References
Homo sapiens mechanistic target of rapamycin (serine/threonine kinase) Starlite/ChEMBL References
Rattus norvegicus Estrogen receptor beta Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 4 Starlite/ChEMBL References
Homo sapiens ataxin 2 Starlite/ChEMBL References
Homo sapiens emopamil binding protein (sterol isomerase) Starlite/ChEMBL References
Rattus norvegicus Aldehyde oxidase Starlite/ChEMBL References
Homo sapiens euchromatic histone-lysine N-methyltransferase 2 Starlite/ChEMBL References
Homo sapiens hydroxysteroid (17-beta) dehydrogenase 10 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2B, G protein-coupled Starlite/ChEMBL References
Homo sapiens dopamine receptor D1 Starlite/ChEMBL References
Homo sapiens phospholipase D2 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily D, polypeptide 6 Starlite/ChEMBL References
Homo sapiens FYN proto-oncogene, Src family tyrosine kinase Starlite/ChEMBL References
Homo sapiens microtubule-associated protein tau Starlite/ChEMBL References
Homo sapiens nuclear receptor subfamily 1, group I, member 2 Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 9 Starlite/ChEMBL References
Bacillus anthracis Anthrax lethal factor Starlite/ChEMBL References
Homo sapiens opioid receptor, mu 1 Starlite/ChEMBL References
Rattus norvegicus Estrogen receptor alpha Starlite/ChEMBL References
Homo sapiens ubiquitin specific peptidase 2 Starlite/ChEMBL References
Rattus norvegicus Peripheral myelin protein 22 Starlite/ChEMBL References
Homo sapiens multiple endocrine neoplasia I References
Homo sapiens sigma non-opioid intracellular receptor 1 Starlite/ChEMBL References
Homo sapiens thrombopoietin Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2C Starlite/ChEMBL References
Rattus norvegicus Alpha-1b adrenergic receptor Starlite/ChEMBL References
Homo sapiens estrogen receptor 2 (ER beta) References
Homo sapiens aldehyde dehydrogenase 1 family, member A1 Starlite/ChEMBL References
Homo sapiens aldehyde oxidase 1 Starlite/ChEMBL References
Rattus norvegicus Alpha-1a adrenergic receptor Starlite/ChEMBL References
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Curated by TDR Targets References
Homo sapiens adrenoceptor alpha 1D Starlite/ChEMBL References
Homo sapiens estrogen receptor 1 Starlite/ChEMBL References
Rattus norvegicus Serotonin 1b (5-HT1b) receptor Starlite/ChEMBL References
Homo sapiens acetylcholinesterase (Yt blood group) Starlite/ChEMBL References
Homo sapiens phospholipase D1, phosphatidylcholine-specific Starlite/ChEMBL References
Homo sapiens adenosine A2a receptor Starlite/ChEMBL References
Homo sapiens glucosidase, beta, acid Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 6, G protein-coupled Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 2 Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2A, G protein-coupled Starlite/ChEMBL References
Homo sapiens 5-hydroxytryptamine (serotonin) receptor 2C, G protein-coupled Starlite/ChEMBL References
Homo sapiens tumor protein p53 Starlite/ChEMBL References
Homo sapiens peroxisome proliferator-activated receptor delta Starlite/ChEMBL References
Homo sapiens tachykinin receptor 2 Starlite/ChEMBL References
Homo sapiens solute carrier family 6 (neurotransmitter transporter), member 3 Starlite/ChEMBL References
Homo sapiens lamin A/C Starlite/ChEMBL References
Homo sapiens dopamine receptor D3 Starlite/ChEMBL References
Homo sapiens ATPase family, AAA domain containing 5 Starlite/ChEMBL References
Macaca fascicularis Aldehyde oxidase Starlite/ChEMBL References
Saccharomyces cerevisiae C-8 sterol isomerase ERG2 Starlite/ChEMBL References
Homo sapiens lysine (K)-specific methyltransferase 2A Starlite/ChEMBL References
Homo sapiens dopamine receptor D2 Starlite/ChEMBL References
Homo sapiens adrenoceptor alpha 2B Starlite/ChEMBL References
Homo sapiens cytochrome P450, family 2, subfamily C, polypeptide 19 Starlite/ChEMBL References
Homo sapiens androgen receptor Starlite/ChEMBL References
Homo sapiens tyrosyl-DNA phosphodiesterase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum ko:K07203 FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni microtubule-associated protein tau Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Serotonin receptor Get druggable targets OG5_135430 All targets in OG5_135430
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core Get druggable targets OG5_139225 All targets in OG5_139225
Trypanosoma brucei gambiense farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum Sodium-dependent noradrenaline transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans Phospholipase D:required for commitment to meiosis Get druggable targets OG5_128363 All targets in OG5_128363
Trypanosoma congolense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Mycobacterium tuberculosis Probable carbon monoxyde dehydrogenase (large chain) Get druggable targets OG5_127252 All targets in OG5_127252
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum ko:K01113 phosphodiesterase/alkaline phosphatase D [EC3.1.4.1], putative Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Candida albicans Phospholipase D:required for commitment to meiosis Get druggable targets OG5_128363 All targets in OG5_128363
Neospora caninum Multidomain chromatinic protein with the following architecture: 3x PHD-bromo-3xPHD-SET domain and associated cysteine cluster a Get druggable targets OG5_130642 All targets in OG5_130642
Echinococcus granulosus microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum ko:K05703 proto-oncogene tyrosine-protein kinase Fyn, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K09188 myeloid/lymphoid or mixed-lineage leukemia protein 3, putative Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Aldehyde dehydrogenase X, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) serotonin transporter b Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania braziliensis ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei gambiense phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Toxoplasma gondii aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) intermediate filament tail domain-containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Brugia malayi Serotonin/octopamine receptor family protein 7 Get druggable targets OG5_141128 All targets in OG5_141128
Leishmania mexicana 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Srms Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei phosphatidylinositol 4-kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis musashi Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis set domain proteins, putative Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) acetylcholinesterase 1 Get druggable targets OG5_126875 All targets in OG5_126875
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Candida albicans cytochrome P450 56 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni norepinephrine/norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma congolense farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis lamin Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Leishmania major cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum IPR000175,Sodium:neurotransmitter symporter,domain-containing Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma mansoni amine GPCR Get druggable targets OG5_128924 All targets in OG5_128924
Leishmania donovani aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis aldehyde oxidase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Trypanosoma congolense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) Get druggable targets OG5_126875 All targets in OG5_126875
Mycobacterium ulcerans aerobic-type carbon monoxide dehydrogenase subunit CoxL_2 Get druggable targets OG5_127252 All targets in OG5_127252
Schistosoma japonicum Acetylcholinesterase 1 precursor, putative Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma brucei gambiense phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus aldehyde dehydrogenase mitochondrial Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum 5-hydroxytryptamine receptor 1, putative Get druggable targets OG5_132667 All targets in OG5_132667
Loa Loa (eye worm) pre-SET domain-containing protein family protein Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma japonicum Alpha-1D adrenergic receptor, putative Get druggable targets OG5_128924 All targets in OG5_128924
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Echinococcus multilocularis carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus granulosus farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi Phospholipase d protein 1 Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma congolense Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania braziliensis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Candida albicans Mitochondrial aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans frameshifted from upsteam TOR2 CDS (CaP19.9461) Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus lamin Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus multilocularis tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trypanosoma brucei gambiense ubiquitin carboxyl-terminal hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma congolense ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi ERG2 and Sigma1 receptor like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania mexicana cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Cryptosporidium hominis scully CG7113-PA Get druggable targets OG5_129031 All targets in OG5_129031
Mycobacterium tuberculosis Probable aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Brugia malayi Pre-SET motif family protein Get druggable targets OG5_131470 All targets in OG5_131470
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus multilocularis tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Echinococcus granulosus carboxylesterase 5A Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans carbon monoxide dehydrogenase Get druggable targets OG5_127252 All targets in OG5_127252
Leishmania braziliensis aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania infantum 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma japonicum ko:K01115 phospholipase D [EC3.1.4.4], putative Get druggable targets OG5_128363 All targets in OG5_128363
Neospora caninum hypothetical protein Get druggable targets OG5_126638 All targets in OG5_126638
Schistosoma japonicum Intermediate filament protein ifa-1, putative Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania major aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Trypanosoma cruzi farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trypanosoma brucei farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Mycobacterium tuberculosis Probable geranylgeranyl pyrophosphate synthetase IdsA2 (ggppsase) (GGPP synthetase) (geranylgeranyl diphosphate synthase) Get druggable targets OG5_127590 All targets in OG5_127590
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K01115 phospholipase D [EC3.1.4.4], putative Get druggable targets OG5_128363 All targets in OG5_128363
Schistosoma japonicum expressed protein Get druggable targets OG5_127431 All targets in OG5_127431
Toxoplasma gondii polyprenyl synthetase superfamily protein Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum ko:K07611 lamin, putative Get druggable targets OG5_128723 All targets in OG5_128723
Entamoeba histolytica phospholipase D active site domain-containing protein Get druggable targets OG5_128363 All targets in OG5_128363
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum Phospholipase D1, putative Get druggable targets OG5_128363 All targets in OG5_128363
Plasmodium vivax geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium ulcerans cytochrome P450 185A4 Cyp185A4 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus tyrosine protein kinase Lyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Brugia malayi SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Cryptosporidium hominis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania mexicana farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Giardia lamblia Farnesyl diphosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi Polyprenyl synthetase family protein Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum 5-hydroxytryptamine receptor, putative Get druggable targets OG5_132667 All targets in OG5_132667
Cryptosporidium hominis ubiquitin specific protease 66 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma japonicum IPR015063,Domain of unknown function DUF1873,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Neospora caninum Phosphatidylinositol 3-kinase tor2, related Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FGR, putative Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum IPR001394,Peptidase C19, ubiquitin carboxyl-terminal hydrolase 2,domain-containing Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma brucei gambiense tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania donovani C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Retinal dehydrogenase 1, putative Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus tyrosine protein kinase Src42A Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase Get druggable targets OG5_129031 All targets in OG5_129031
Leishmania donovani Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei gambiense cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania donovani cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) polyprenyl synthetase Get druggable targets OG5_127590 All targets in OG5_127590
Cryptosporidium parvum tyrosyl-DNA phodphodiesterase 1 (tdp1) Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus multilocularis lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Candida albicans ubiquitin-specific protease Get druggable targets OG5_127431 All targets in OG5_127431
Cryptosporidium hominis hypothetical protein Get druggable targets OG5_129037 All targets in OG5_129037
Leishmania major target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus transcription factor Dp 1 Get druggable targets OG5_129037 All targets in OG5_129037
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Get druggable targets OG5_128924 All targets in OG5_128924
Leishmania infantum tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127212 All targets in OG5_127212
Theileria parva farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum ko:K01072 ubiquitin thiolesterase [EC3.1.2.15], putative Get druggable targets OG5_127431 All targets in OG5_127431
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_139759 All targets in OG5_139759
Leishmania donovani farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum Conserved hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Candida albicans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) SRC-1 Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania infantum target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase Yrk, putative Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus cytoplasmic intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K04165 Oamb gene product from transcript, putative Get druggable targets OG5_141128 All targets in OG5_141128
Echinococcus multilocularis tyrosine protein kinase Src64B Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_144688 All targets in OG5_144688
Echinococcus granulosus phospholipase D1 Get druggable targets OG5_128363 All targets in OG5_128363
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major target of rapamycin (TOR) kinase 1, putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum expressed protein Get druggable targets OG5_128363 All targets in OG5_128363
Loa Loa (eye worm) cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus multilocularis farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126582 All targets in OG5_126582
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Carboxylesterase family protein Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania braziliensis target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania infantum target of rapamycin (TOR) kinase 2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to N terminal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) putative protein/phosphatidylinositol kinases in Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Schistosoma japonicum Lamin-C, putative Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum ko:K01049 acetylcholinesterase [EC3.1.1.7], putative Get druggable targets OG5_126875 All targets in OG5_126875
Trypanosoma congolense Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Loa Loa (eye worm) phosphatidylinositol 3 Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum ko:K00022 3-hydroxyacyl-CoA dehydrogenase [EC1.1.1.35], putative Get druggable targets OG5_129031 All targets in OG5_129031
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania major farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Brugia malayi O-Glycosyl hydrolase family 30 protein Get druggable targets OG5_129423 All targets in OG5_129423
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans frameshifted from upstream TOR2 CDS (CaP19.1905) Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K00128 aldehyde dehydrogenase (NAD+) [EC1.2.1.3], putative Get druggable targets OG5_126638 All targets in OG5_126638
Entamoeba histolytica phospholipase D, putative Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus multilocularis phospholipase D1 Get druggable targets OG5_128363 All targets in OG5_128363
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum ko:K08892 fyn-related kinase, putative Get druggable targets OG5_127750 All targets in OG5_127750
Giardia lamblia GTOR Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Plasmodium knowlesi geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 Get druggable targets OG5_127431 All targets in OG5_127431
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Loa Loa (eye worm) carboxylesterase Get druggable targets OG5_126875 All targets in OG5_126875
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_139759 All targets in OG5_139759
Candida albicans sterol C8-C7 isomerase Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis microtubule associated protein 2 Get druggable targets OG5_133504 All targets in OG5_133504
Toxoplasma gondii histone lysine methyltransferase SET1 Get druggable targets OG5_130642 All targets in OG5_130642
Treponema pallidum sodium- and chloride- dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily Get druggable targets OG5_145685 All targets in OG5_145685
Schistosoma japonicum Menin, putative Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Cytochrome P450 family protein Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma cruzi C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Leishmania mexicana tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Mycobacterium ulcerans carbon monoxyde dehydrogenase large chain CoxL Get druggable targets OG5_127252 All targets in OG5_127252
Leishmania donovani ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania mexicana phosphatidylinositol 3-kinase (tor2)-like protein Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) TK protein kinase Get druggable targets OG5_127750 All targets in OG5_127750
Plasmodium yoelii farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma mansoni sodium/chloride dependent transporter Get druggable targets OG5_128364 All targets in OG5_128364
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania infantum cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_131051 All targets in OG5_131051
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Aldehyde dehydrogenase, mitochondrial precursor, putative Get druggable targets OG5_126638 All targets in OG5_126638
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Brugia malayi Sodium:neurotransmitter symporter family protein Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus multilocularis acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Leishmania braziliensis 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Trichomonas vaginalis xanthine dehydrogenase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Leishmania mexicana phosphatidylinositol 3 kinase, putative Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni mixed-lineage leukemia protein mll Get druggable targets OG5_130642 All targets in OG5_130642
Schistosoma japonicum Proto-oncogene tyrosine-protein kinase FYN, putative Get druggable targets OG5_127750 All targets in OG5_127750
Brugia malayi Intermediate filament tail domain containing protein Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans similar to internal region of S. cerevisiae TOR2 (YKL203C) and TOR1 (YJR066W) protein/phosphatidylinositol kinases involved in n Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis xanthine dehydrogenase, putative Get druggable targets OG5_127252 All targets in OG5_127252
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Schistosoma japonicum FKBP12-rapamycin complex-associated protein, putative Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 Get druggable targets OG5_129031 All targets in OG5_129031
Schistosoma mansoni intermediate filament proteins Get druggable targets OG5_128723 All targets in OG5_128723
Cryptosporidium parvum putative farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Leishmania major tyrosyl-DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128363 All targets in OG5_128363
Trypanosoma brucei C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Leishmania donovani tyrosyl-DNA phosphodiesterase-like protein Get druggable targets OG5_129037 All targets in OG5_129037
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_127431 All targets in OG5_127431
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_141128 All targets in OG5_141128
Cryptosporidium parvum scully CG7113-PA, putative Get druggable targets OG5_129031 All targets in OG5_129031
Cryptosporidium parvum ubiquitin C-terminal hydrolase of the cysteine proteinase fold Get druggable targets OG5_127431 All targets in OG5_127431
Leishmania infantum aldehyde dehydrogenase, mitochondrial precursor Get druggable targets OG5_126638 All targets in OG5_126638
Echinococcus granulosus tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Neospora caninum hypothetical protein Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus multilocularis dnaJ subfamily B Get druggable targets OG5_133913 All targets in OG5_133913
Loa Loa (eye worm) solute carrier family 6 member 4 Get druggable targets OG5_128364 All targets in OG5_128364
Toxoplasma gondii target of rapamycin (TOR), putative Get druggable targets OG5_127212 All targets in OG5_127212
Candida albicans similar to S. cerevisiae ERG20 (YJL167W) farnesyl diphosphate synthetase (FPP synthetase) Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) norepinephrine transporter Get druggable targets OG5_128364 All targets in OG5_128364
Plasmodium berghei geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Schistosoma japonicum ko:K05336 solute carrier family 6 (neurotransmitter transporter), invertebrate, putative Get druggable targets OG5_128364 All targets in OG5_128364
Trypanosoma brucei gambiense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Mycobacterium ulcerans short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis tyrosine protein kinase Fgr Get druggable targets OG5_127750 All targets in OG5_127750
Leishmania donovani 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Glucosylceramidase homolog Get druggable targets OG5_129423 All targets in OG5_129423
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus tyrosine protein kinase Blk Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Babesia bovis farnesyl pyrophosphate synthetase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Leishmania infantum C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_131470 All targets in OG5_131470
Echinococcus granulosus phospholipase D Get druggable targets OG5_128363 All targets in OG5_128363
Leishmania braziliensis tyrosyl-DNA phosphodiesterase, putative;with=GeneDB:LinJ33_V3.3210 Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma japonicum Ubiquitin carboxyl-terminal hydrolase 8, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania braziliensis cytochrome p450-like protein Get druggable targets OG5_126554 All targets in OG5_126554
Schistosoma japonicum ko:K04380 microtubule-associated protein tau, putative Get druggable targets OG5_133504 All targets in OG5_133504
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative Get druggable targets OG5_129031 All targets in OG5_129031
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative Get druggable targets OG5_127431 All targets in OG5_127431
Trypanosoma cruzi cytochrome P450, putative Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase Get druggable targets OG5_129031 All targets in OG5_129031
Candida albicans closely related to C.maltosa N-alkane-inducible cytochrome P-450, alkane hydroxylating monooxygenase CYP52A3-b aka P450Alk1A (BA Get druggable targets OG5_126554 All targets in OG5_126554
Mycobacterium ulcerans geranylgeranyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis glucosylceramidase, putative Get druggable targets OG5_129423 All targets in OG5_129423
Echinococcus granulosus ubiquitin specific protease 41 Get druggable targets OG5_127431 All targets in OG5_127431
Brugia malayi protein-tyrosine kinase Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 Get druggable targets OG5_129037 All targets in OG5_129037
Trypanosoma congolense C-8 sterol isomerase, putative Get druggable targets OG5_131051 All targets in OG5_131051
Loa Loa (eye worm) intermediate filament protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus FKBP12 rapamycin complex associated protein Get druggable targets OG5_127212 All targets in OG5_127212
Leishmania donovani Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus granulosus tm gpcr rhodopsin Get druggable targets OG5_145685 All targets in OG5_145685
Leishmania major C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related Get druggable targets OG5_127212 All targets in OG5_127212
Mycobacterium ulcerans aldehyde dehydrogenase Get druggable targets OG5_126638 All targets in OG5_126638
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_126875 All targets in OG5_126875
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus lamin dm0 Get druggable targets OG5_128723 All targets in OG5_128723
Schistosoma mansoni lamin Get druggable targets OG5_128723 All targets in OG5_128723
Leishmania infantum farnesyl pyrophosphate synthase Get druggable targets OG5_127590 All targets in OG5_127590
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma mansoni tyrosyl-DNA phosphodiesterase Get druggable targets OG5_129037 All targets in OG5_129037
Schistosoma mansoni hypothetical protein Get druggable targets OG5_133913 All targets in OG5_133913
Leishmania braziliensis C-8 sterol isomerase-like protein Get druggable targets OG5_131051 All targets in OG5_131051
Entamoeba histolytica phospholipase D, putative Get druggable targets OG5_128363 All targets in OG5_128363
Echinococcus multilocularis tyrosine protein kinase HCK Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus acetylcholinesterase Get druggable targets OG5_126875 All targets in OG5_126875
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk Get druggable targets OG5_127750 All targets in OG5_127750
Echinococcus granulosus tumor protein p63 Get druggable targets OG5_140038 All targets in OG5_140038
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase Get druggable targets OG5_127431 All targets in OG5_127431
Candida albicans similar to C.maltosa N-alkane inducible cytochrome P-450, ALK8 CYP52A11 Get druggable targets OG5_126554 All targets in OG5_126554
Trichomonas vaginalis PIKK family atypical protein kinase Get druggable targets OG5_127212 All targets in OG5_127212
Schistosoma japonicum Sodium-dependent dopamine transporter, putative Get druggable targets OG5_128364 All targets in OG5_128364
Loa Loa (eye worm) CYP4Cod1 Get druggable targets OG5_126554 All targets in OG5_126554
Echinococcus granulosus serotonin transporter Get druggable targets OG5_128364 All targets in OG5_128364
Candida albicans cytochrome P450 556 Get druggable targets OG5_126554 All targets in OG5_126554
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 Get druggable targets OG5_127212 All targets in OG5_127212
Echinococcus multilocularis tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750
Onchocerca volvulus Get druggable targets OG5_128723 All targets in OG5_128723
Echinococcus granulosus tyrosine protein kinase Fyn Get druggable targets OG5_127750 All targets in OG5_127750

By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Brugia malayi cytochrome P450 cytochrome P450, family 3, subfamily A, polypeptide 4 502 aa 492 aa 24.2 %
Mycobacterium tuberculosis Succinate-semialdehyde dehydrogenase [NADP+] dependent (SSDH) GabD1 aldehyde dehydrogenase 1 family, member A1 501 aa 456 aa 33.3 %
Brugia malayi follicle stimulating hormone receptor adenosine A2a receptor 412 aa 336 aa 22.3 %
Plasmodium falciparum ubiquitin specific protease, putative ubiquitin specific peptidase 2 362 aa 378 aa 25.7 %
Rattus norvegicus hypothetical protein Peripheral myelin protein 22   160 aa 129 aa 25.6 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 3 620 aa 579 aa 33.2 %
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase hydroxysteroid (17-beta) dehydrogenase 10 252 aa 251 aa 24.7 %
Leishmania major cytochrome p450-like protein cytochrome P450, family 2, subfamily C, polypeptide 19 490 aa 411 aa 23.1 %
Rattus norvegicus retinoic acid receptor RXR Estrogen receptor   530 aa 451 aa 25.5 %
Brugia malayi cytochrome P450 cytochrome P450, family 2, subfamily D, polypeptide 6 497 aa 425 aa 32.0 %
Mycobacterium tuberculosis Probable cytochrome P450 136 Cyp136 cytochrome P450, family 2, subfamily C, polypeptide 9 490 aa 441 aa 21.8 %
Brugia malayi ecdysteroid receptor peroxisome proliferator-activated receptor delta 441 aa 369 aa 24.7 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 2 617 aa 638 aa 32.5 %
Brugia malayi hypothetical protein dopamine receptor D3 400 aa 392 aa 19.9 %
Brugia malayi ecdysteroid receptor nuclear receptor subfamily 1, group I, member 2 434 aa 427 aa 25.1 %
Brugia malayi Sodium:neurotransmitter symporter family protein solute carrier family 6 (neurotransmitter transporter), member 4 630 aa 574 aa 31.5 %
Rattus norvegicus Alpha-1b adrenergic receptor   515 aa 429 aa 20.3 %
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 geranylgeranyl pyrophosphate synthase, putative 376 aa 333 aa 22.5 %
Rattus norvegicus g protein coupled receptor Alpha-1a adrenergic receptor   466 aa 414 aa 20.5 %
Rattus norvegicus amine GPCR Muscarinic acetylcholine receptor M1   460 aa 463 aa 27.0 %
Rattus norvegicus sulfakinin receptor protein Serotonin 1b (5-HT1b) receptor   386 aa 344 aa 23.3 %
Rattus norvegicus retinoic acid receptor RXR Estrogen receptor beta   530 aa 451 aa 25.5 %
Brugia malayi Carboxylesterase family protein acetylcholinesterase (Yt blood group) 614 aa 510 aa 26.5 %
Loa Loa (eye worm) hypothetical protein estrogen receptor 2 (ER beta) 495 aa 418 aa 25.8 %
Echinococcus granulosus ecdysone induced protein 78C nuclear receptor subfamily 1, group H, member 4 476 aa 402 aa 28.1 %

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species

Activities

Activity type Activity value Assay description Source Reference
(functional) = 28.9 mg Uterine weight assay of ovx type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
(functional) = 52 mg Uterine weight assay of compound was determined invivo against estrogen receptor alpha ChEMBL. 15713417
(functional) = 203.4 mg Uterine weight assay of sham type raloxifene was determinedn invivo against estrogen receptor alpha ChEMBL. 15713417
(functional) = 386.2 mg/cm3 Bone mineral density of ovx type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
(functional) = 549.1 mg/cm3 Effect on mouse bone mineral density ChEMBL. 15713417
(functional) = 592 mg/cm3 Bone mineral density of sham type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
Activity (binding) Binding affinity to hound collagen 1a1 (unknown origin) at 50 uM after 1 8 hrs by 1H NMR spectroscopic analysis ChEMBL. 26795112
Activity (functional) Agonist activity at human wild type ERbeta expressed in human HeLa cells co-expressing AP-1 assessed as transactivation activity by luciferase reporter gene assay ChEMBL. 20659801
Activity (binding) Transactivation of human wild type ERalpha expressed in human HeLa cells co-expressing AP-1 by luciferase reporter gene assay ChEMBL. 20659801
Activity (functional) Antagonist activity at human wild type ERbeta expressed in human HeLa cells co-expressing ERE assessed as inhibition of transactivation activity by luciferase reporter gene assay ChEMBL. 20659801
Activity (ADMET) Agonist activity at ERalpha in estrogen-sensitive human T47D cells assessed as induction of cell proliferation at 0 LITERATURE. 27155470
Activity (binding) Agonist activity at ERalpha in human Saos2 cells assessed as increase in ALP activity using p-nitrophenyl phosphate as substrate at 0 LITERATURE. 27155470
Activity (functional) Antagonist activity at human wild type ERalpha expressed in human HeLa cells co-expressing ERE assessed as inhibition of transactivation activity by luciferase reporter gene assay ChEMBL. 20659801
Activity (binding) Down regulation of ERalpha in human MCF7 cells at 10 uM after 6 hrs by Western blot analysis ChEMBL. 27185013
Activity (binding) Agonist activity at ERalpha in human Saos2 cells assessed as induction of cell proliferation at 1 nM to 1 uM after 7 days by MTS assay LITERATURE. 27155470
Activity (binding) Agonist activity at ERalpha in human Saos2 cells assessed as induction of cell proliferation at 1 uM after 7 days by MTS assay LITERATURE. 27155470
Activity (functional) Agonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity at 10 uM after 3 days by chemiluminescence assay ChEMBL. 19366247
Activity (ADMET) Effect on CYP3A4 (unknown origin) apoprotein formation at 10 uM pre-incubated for 3 mins by mass spectrometry analysis in presence of 1 mM NADPH ChEMBL. 21447734
Activity (functional) Agonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation at 10 uM after 24 hrs by [14C]thymidine incorporation assay ChEMBL. 19366247
Activity (binding) Binding affinity to GP130 in human RH30 cells assessed as protection against pronase-induced cleavage at 100 to 1000 uM preincubated for 1 hr followed by pronase induction measured after 30 mins by DARTS assay ChEMBL. 24456369
Activity (ADMET) Effect on recombinant CYP3A4 (unknown origin) expressed in baculosomes assessed as heme level LC/UV/MS analysis in presence of 1 mM NADPH ChEMBL. 21447734
Activity (functional) 0 Agonist activity at estrogen receptor in Ishikawa cells at 10 uM ChEMBL. 16722623
Activity (functional) 0 Agonist activity at estrogen receptor in MCF7 cells at 10 uM ChEMBL. 16722623
Activity (functional) = -7.2 % Agonist activity at human recombinant dopamine D1 receptor expressed in CHOK1 cells assessed as stimulation of cAMP accumulation at 100 uM after 30 mins by HTRF assay relative to SKF81297 ChEMBL. 24088053
Activity (binding) = 4.7 % Agonist activity at human recombinant dopamine D2 long receptor expressed in CHOK1 cells coexpressing mitochondrial apoaequorin at 100 uM by luminometric analysis relative to quinpirol ChEMBL. 24088053
Activity (functional) = 22 % Percent agonist activity against human breast adenocarcinoma (MCF-7) cell proliferation ChEMBL. 15658851
Activity (functional) = 22 % Percent agonist activity against human breast adenocarcinoma (MCF-7) cell proliferation ChEMBL. 15658851
Activity (functional) = 24 % Agonistic activity in rat in vivo uterine weight assay at 1 mg/kg oral dose ChEMBL. 15582421
Activity (functional) = 24 % In vivo agonism of estradiol in rat uterine tissue after 1 mg/kg, po by uterine weight assay ChEMBL. 16203138
Activity (functional) = 24 % Agonistic activity in rat in vivo uterine weight assay at 1 mg/kg oral dose ChEMBL. 15582421
Activity (functional) = 30 % Percent uterine growth in female ovariectomized rat at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 30 % Percent uterine growth in female ovariectomized rat at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 64 % Bone mineral density of DFM:central in female ovariectomized rats at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 64 % Bone mineral density of DFM:central in female ovariectomized rats at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 74 % Bone mineral density of DFM:central in female ovariectomized rats at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 74 % Bone mineral density of DFM:central in female ovariectomized rats at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Activity (functional) = 81 % Antagonistic activity in rat in vivo uterine weight assay after 1 mg/kg oral dose ChEMBL. 15582421
Activity (functional) = 81 % In vivo antagonism of estradiol in rat uterine tissue after 1 mg/kg, po by uterine weight assay ChEMBL. 16203138
Activity (functional) = 81 % Antagonistic activity in rat in vivo uterine weight assay after 1 mg/kg oral dose ChEMBL. 15582421
Activity (functional) = 69.5 mg Effect on uterine wet weight in ovariectomized kunming mouse at 4 umol/kg, sc qd for 4 weeks ChEMBL. 17574424
Activity (functional) = 69.5 mg Effect on uterine wet weight in ovariectomized kunming mouse at 4 umol/kg, sc qd for 4 weeks ChEMBL. 17574424
Activity (functional) = 608 mg/cm3 Effect on bone mineral density in ovariectomized kunming mouse at 4 umol/kg, sc qd for 4 weeks ChEMBL. 17574424
Activity (functional) = 608 mg/cm3 Effect on bone mineral density in ovariectomized kunming mouse at 4 umol/kg, sc qd for 4 weeks ChEMBL. 17574424
Agonist (functional) = 0 % Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells compared to estradiol ChEMBL. 12749898
Agonist (functional) = 0 % Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells compared to estradiol ChEMBL. 12749898
Agonist (functional) = 118 % Percent agonistic activity towards uterus effects in ovariectomized mice after 4 weeks of 4 umol/kg subcutaneous administration (n=5) ChEMBL. 15911274
Agonist (functional) = 118 % Percent agonistic activity towards uterus effects in ovariectomized mice after 4 weeks of 4 umol/kg subcutaneous administration (n=5) ChEMBL. 15911274
Bioavailabiility (ADMET) = 2 % Bioavailability was determined; extremely poor ChEMBL. 12646017
Bioavailabiility (ADMET) = 5 % Oral bioavailability of the compound in cynomolgus monkey. ChEMBL. 9685230
BMD (functional) = 565 mg/cm3 Increased bone mineral density in ovariectomized Kun-Ming mice after subcutaneous administration at 4 umol/kg for 4 weeks (n=5) ChEMBL. 15911274
BMD (functional) = 565 mg/cm3 Increased bone mineral density in ovariectomized Kun-Ming mice after subcutaneous administration at 4 umol/kg for 4 weeks (n=5) ChEMBL. 15911274
Bone mineral density (functional) = 386.2 mg/cm3 Bone mineral density of ovx type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
Bone mineral density (functional) = 549.1 mg/cm3 Effect on mouse bone mineral density ChEMBL. 15713417
Bone mineral density (functional) = 592 mg/cm3 Bone mineral density of sham type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
CL (ADMET) < 6 microL/min/mg Intrinsic clearance in mouse liver microsomes in presence of UGT ChEMBL. 21334892
CL (ADMET) = 21 microL/min/mg Clearance in human ChEMBL. 21334892
CL (ADMET) = 66 microL/min/mg Intrinsic clearance in mouse liver microsomes in presence of NADPH ChEMBL. 21334892
CL (ADMET) = 108 microL/min/mg Clearance in mouse ChEMBL. 21334892
CL (ADMET) = 157.7 ml min-1 kg-1 Total clearance of compound in rat after administration of 1 mg/kg (iv) and 5 mg/kg (po) ChEMBL. 15658851
CL (ADMET) = 0 ml/min.kg Renal clearance in human ChEMBL. 22685216
CL (ADMET) = 735 ml/min.kg Plasma clearance in po dosed human ChEMBL. 21282406
Cmax (ADMET) = 7.5 nM Maximum plasma concentration of compound in rat after peroral administration of 5 mg/kg ChEMBL. 15658851
Decrease (functional) = 40 % Effect on spine fractures in postmenopausal women with osteoporosis ChEMBL. 12646017
Decrease (functional) = 40 % Effect on spine fractures in postmenopausal women with osteoporosis ChEMBL. 12646017
Decrease (functional) = 44.9 % Percent decrease in serum cholesterol relative to OVX controls, at 0.01 mg/Kg compound dose ChEMBL. 9548817
Decrease (functional) = 44.9 % Percent decrease in serum cholesterol relative to OVX control at 0.1 mg/kg in rat was determined (in vivo) ChEMBL. 9003514
Decrease (functional) = 66.7 % Percent decrease in serum cholesterol relative to OVX controls, at 0.1 mg/Kg compound dose ChEMBL. 9548817
Decrease (functional) = 66.7 % Percent decrease in serum cholesterol relative to OVX control at 1 mg/kg in rat ChEMBL. 9003514
Decrease (functional) = 74 % Percent decrease in serum cholesterol relative to OVX control at 10 mg/kg in rat was determined (in vivo) ChEMBL. 9003514
delta logD (ADMET) = -0.9 Delta logD (logD6.5 - logD7.4) ChEMBL. 10891117
Drug metabolism (ADMET) Activity of human UGT1A8 expressed in insect cells assessed as reduction in compound level after 30 mins ChEMBL. 22685216
Drug metabolism (ADMET) Activity of human UGT1A10 expressed in insect cells assessed as reduction in compound level after 30 mins ChEMBL. 22685216
E max (functional) = 15 % Percent stimulation of alkaline phosphatase activity in Ishikawa human endometrial adenocarcinoma cells relative to moxestrol ChEMBL. 11738564
E max (functional) = 15 % Percent stimulation of alkaline phosphatase activity in Ishikawa human endometrial adenocarcinoma cells relative to moxestrol ChEMBL. 11738564
EC50 (functional) nM Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells; ND= not determined ChEMBL. 12749898
EC50 (functional) 0 nM Percent agonistic activity for estrogen-induced pS2 expression in MCF-7 cells; ND= not determined ChEMBL. 12749898
EC50 (functional) = 0.04 nM Stimulation of alkaline phosphatase acivity in Ishikawa human endometrial adenocarcinoma cells ChEMBL. 11738564
EC50 (functional) = 0.04 nM Stimulation of alkaline phosphatase acivity in Ishikawa human endometrial adenocarcinoma cells ChEMBL. 11738564
EC50 (binding) = 22 nM Inhibition of [3H]-17-beta-estradiol binding to human recombinant Estrogen receptor alpha. ChEMBL. 11906280
EC50 (binding) = 22 nM Inhibition of [3H]-17-beta-estradiol binding to human recombinant Estrogen receptor alpha. ChEMBL. 11906280
EC50 (binding) = 260 nM Inhibition of [3H]-17-beta-estradiol binding to human recombinant Estrogen receptor beta. ChEMBL. 11906280
EC50 (binding) = 260 nM Inhibition of [3H]-17-beta-estradiol binding to human recombinant Estrogen receptor beta. ChEMBL. 11906280
EC50 (binding) = 0.022 uM Activity against estrogen receptor alpha ChEMBL. 18457385
EC50 (functional) = 10 uM Antitrypanosomal activity against Trypanosoma cruzi amastigotes infected in BESM cells measured after 88 hrs postinfection by HTS assay ChEMBL. 20547819
EC50 (binding) = 11.71 uM Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation after 16 hrs by luciferase reporter gene assay ChEMBL. 23688559
EC50 (functional) = 23 uM Antiproliferative activity against human ER-negative MCF7 cells after 24 hrs by MTT assay ChEMBL. 25198997
ED50 (functional) = 0.2 mg kg-1 Dose required to reduce serum cholesterol by 50% relative to ovariectomized(OVX) controls ChEMBL. 9548817
ED50 (functional) = 0.2 mg kg-1 Dose required to reduce serum cholesterol by 50% relative to OVX controls was determined (in vivo) ChEMBL. 9003514
ED50 (functional) = 500 ug day-1 kg-1 In vivo prevention of bone loss in ovariectomised rats on oral administration ChEMBL. 9685230
ED50 (functional) = 500 ug day-1 kg-1 In vivo prevention of reduced serum cholesterol in ovariectomised rats on oral administration ChEMBL. 9685230
Efficacy (binding) = 0 % Agonist activity at estrogen receptor alpha in human MCF7:WS8 cells after 18 hrs by dual luciferase reporter assay relative to E2 ChEMBL. 26681208
F (ADMET) = 2 % Oral bioavailability in human ChEMBL. 17870541
F (ADMET) = 2 % Oral bioavailability in human ChEMBL. 17870541
F (ADMET) = 2 % Bioavailability in human ChEMBL. 21334892
F (ADMET) = 10 % Oral bioavailability in rat ChEMBL. 9685230
F (ADMET) = 10 % Bioavailability in mouse ChEMBL. 21334892
F (ADMET) < 20 % Oral bioavailability in human ChEMBL. 10891117
F (ADMET) = 22 % Oral bioavailability in rat (dose 5 mg/kg) ChEMBL. 15658851
IA (functional) 0 Agonist effect on transcriptional activation in T47D cells expressing estrogen receptor alpha; Inactive at 10e-4 M ChEMBL. 12459017
IA (functional) 0 Agonist effect on transcriptional activation of T47D cells expressing human estrogen receptor beta; Inactive at 10e-4 M ChEMBL. 12459017
IC50 (binding) Inhibition of Agaricus bisporus (mushroom) tyrosinase ChEMBL. 21476569
IC50 (functional) = 0.2 nM Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation ChEMBL. 12749895
IC50 (functional) = 0.2 nM In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation ChEMBL. 10098655
IC50 (functional) = 0.2 nM Inhibition of estrogen-stimulated MCF-7 cell proliferation ChEMBL. 9548817
IC50 (functional) = 0.2 nM Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro) ChEMBL. 9003514
IC50 (functional) = 0.2 nM Inhibition of estradiol-stimulated MCF-7 breast adenocarcinoma cell proliferation ChEMBL. 12749895
IC50 (functional) = 0.2 nM In vitro inhibition of estrogen-stimulated MCF-7 cell proliferation ChEMBL. 10098655
IC50 (functional) = 0.2 nM Antagonism of estrogen action in a mammary tumor cell line was assayed via inhibition of MCF-7 cell proliferation stimulated by 10 e-11 M 17-beta-estradiol (in vitro) ChEMBL. 9003514
IC50 (functional) = 0.2 nM Inhibition of estrogen-stimulated MCF-7 cell proliferation ChEMBL. 9548817
IC50 (functional) = 0.2 nM Antiproliferative activity against human MCF7 cells ChEMBL. 22405286
IC50 (functional) = 0.3 nM Antagonist activity at human wild type ERalpha expressed in HEK293T cells co-expressing ERE assessed as inhibition of estradiol-induced transactivation by luciferase reporter gene assay ChEMBL. 20659801
IC50 (functional) = 0.34 nM Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferation ChEMBL. 10328300
IC50 (functional) = 0.34 nM Inhibition of 17-beta-estradiol (10e-11 M) mediated MCF-7 cell proliferation ChEMBL. 10328300
IC50 (functional) = 0.46 nM Antagonist activity at human ERalpha expressed in african green monkey CV1 cells assessed as inhibition of estrogen like activity after 24 hrs by luciferase reporter gene assay ChEMBL. 16499324
IC50 (binding) = 0.47 nM Displacement of Fluormone ES2 from human recombinant full length untagged-ERalpha by fluorescence polarization competition binding assay ChEMBL. 27185013
IC50 (binding) = 0.7 nM In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alpha ChEMBL. 12459017
IC50 (binding) = 0.7 nM Binding affinity for Rat Estrogen receptor-alpha ChEMBL. 12565955
IC50 (binding) = 0.7 nM In vitro inhibition of transcriptional activation induced by 1 nM 17-beta estradiol in T47D cells expressing estrogen receptor alpha ChEMBL. 12459017
IC50 (binding) = 0.7 nM Binding affinity for Rat Estrogen receptor-alpha ChEMBL. 12565955
IC50 (functional) = 0.72 nM In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiol ChEMBL. 11356100
IC50 (functional) = 0.72 nM In vitro antagonist effect on estrogen receptor alpha transcriptional activation in MCF-7 cells against 10 pM 17-beta-estradiol ChEMBL. 11356100
IC50 (binding) = 0.73 nM Inhibition of estrogen receptor alpha ChEMBL. 15713417
IC50 (binding) = 0.73 nM Inhibition of estrogen receptor alpha ChEMBL. 15713417
IC50 (functional) = 0.8 nM In vitro inhibition of estradiol-stimulated MCF-7 breast cancer cell proliferation ChEMBL. 15582421
IC50 (functional) = 0.8 nM In vitro antagonistic activity against MCF-7 cells was tested using proliferation assay ChEMBL. 15225685
IC50 (functional) = 0.8 nM In vitro antagonistic activity against MCF-7 cells was tested using proliferation assay ChEMBL. 15225686
IC50 (functional) = 0.8 nM Antiproliferative activity against human breast cancer MCF7 cell line in presence of 0.003 nM estradiol ChEMBL. 16203138
IC50 (functional) = 0.8 nM In vitro inhibition of estradiol-stimulated MCF-7 breast cancer cell proliferation ChEMBL. 15582421
IC50 (functional) = 0.8 nM In vitro antagonistic activity against MCF-7 cells was tested using proliferation assay ChEMBL. 15225685
IC50 (functional) = 0.8 nM In vitro antagonistic activity against MCF-7 cells was tested using proliferation assay ChEMBL. 15225686
IC50 (functional) = 0.8 nM Antiproliferative activity against human breast cancer MCF7 cell line in presence of 0.003 nM estradiol ChEMBL. 16203138
IC50 (binding) = 0.89 nM Inhibitino of [3H]-17-beta-estradiol binding to human estrogen receptor alpha ChEMBL. 15911274
IC50 (binding) = 0.89 nM Inhibitino of [3H]-17-beta-estradiol binding to human estrogen receptor alpha ChEMBL. 15911274
IC50 (functional) = 1.4 nM Inhibition of estrogen-mediated human breast adenocarcinoma (MCF-7) cell proliferation ChEMBL. 15658851
IC50 (functional) = 1.4 nM Inhibition of estrogen-mediated human breast adenocarcinoma (MCF-7) cell proliferation ChEMBL. 15658851
IC50 (binding) = 1.6 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta ChEMBL. 15911274
IC50 (binding) = 1.6 nM Inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor beta ChEMBL. 15911274
IC50 (binding) = 1.8 nM Binding affinity towards human estrogen receptor alpha ChEMBL. 15109649
IC50 (binding) = 1.8 nM Binding affinity towards human recombinant Estrogen receptor alpha was determined ChEMBL. 15084115
IC50 (binding) = 1.8 nM Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor alpha ChEMBL. 15125925
IC50 (binding) = 1.8 nM Binding affinity for Human Estrogen receptor-alpha ChEMBL. 12565955
IC50 (binding) = 1.8 nM Binding affinity against human estrogen receptor alpha in competitive binding assay ChEMBL. 15006374
IC50 (binding) = 1.8 nM Inhibition of bindign to recombinant human estrogen receptor alpha ChEMBL. 15582421
IC50 (binding) = 1.8 nM Binding potency for human ER alpha ChEMBL. 15225685
IC50 (binding) = 1.8 nM Binding potency for human ER alpha ChEMBL. 15225686
IC50 (binding) = 1.8 nM Inhibition of binding to recombinant human ERalpha by scintillation proximity assay ChEMBL. 16203138
IC50 (binding) = 1.8 nM Binding affinity to ERalpha ChEMBL. 16722623
IC50 (binding) = 1.8 nM Binding affinity towards human estrogen receptor alpha ChEMBL. 15109649
IC50 (binding) = 1.8 nM Binding affinity towards human recombinant Estrogen receptor alpha was determined ChEMBL. 15084115
IC50 (binding) = 1.8 nM Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor alpha ChEMBL. 15125925
IC50 (binding) = 1.8 nM Binding affinity for Human Estrogen receptor-alpha ChEMBL. 12565955
IC50 (binding) = 1.8 nM Binding affinity against human estrogen receptor alpha in competitive binding assay ChEMBL. 15006374
IC50 (binding) = 1.8 nM Inhibition of bindign to recombinant human estrogen receptor alpha ChEMBL. 15582421
IC50 (binding) = 1.8 nM Binding potency for human ER alpha ChEMBL. 15225685
IC50 (binding) = 1.8 nM Binding potency for human ER alpha ChEMBL. 15225686
IC50 (binding) = 1.8 nM Inhibition of binding to recombinant human ERalpha by scintillation proximity assay ChEMBL. 16203138
IC50 (binding) = 1.8 nM Binding affinity to ERalpha ChEMBL. 16722623
IC50 (binding) = 1.8 nM Displacement of radiolabeled estrogen from estrogen receptor alpha by scintillation counting ChEMBL. 19366247
IC50 (binding) = 1.85 nM Inhibition of estradiol binding to estrogen receptor ChEMBL. 9685230
IC50 (binding) = 1.85 nM Inhibition of estradiol binding to estrogen receptor ChEMBL. 9685230
IC50 (binding) = 1.9 nM Inhibition of human estrogen receptor 2 using tritiated estradiol incubated for 3 hr ChEMBL. 15993065
IC50 (binding) = 1.9 nM Inhibition of human estrogen receptor 2 using tritiated estradiol incubated for 3 hr ChEMBL. 15993065
IC50 (binding) = 2.4 nM Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay ChEMBL. 15658851
IC50 (binding) = 2.4 nM Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor alpha; ERE assay ChEMBL. 15658851
IC50 (functional) = 3.1 nM Ability to inhibit release of interleukin-6 from U2OS cell lines transfected with estrogen receptor alpha ChEMBL. 15177442
IC50 (functional) = 3.1 nM Ability to inhibit release of interleukin-6 from U2OS cell lines transfected with estrogen receptor alpha ChEMBL. 15177442
IC50 (binding) = 3.4 nM Binding affinity foor Rat Estrogen receptor-beta ChEMBL. 12565955
IC50 (binding) = 3.4 nM Binding affinity foor Rat Estrogen receptor-beta ChEMBL. 12565955
IC50 (functional) = 4 nM In vivo inhibition of human ERalpha/ERbeta co-expressed in HEK 293 cells; 4/60 ChEMBL. 15109649
IC50 (binding) = 4 nM In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha ChEMBL. 11356100
IC50 (functional) = 4 nM In vivo inhibition of human ERalpha/ERbeta co-expressed in HEK 293 cells; 4/60 ChEMBL. 15109649
IC50 (binding) = 4 nM In vitro inhibition of [3H]-17-beta-estradiol binding to human estrogen receptor alpha ChEMBL. 11356100
IC50 (functional) = 4.9 nM Antiproliferative activity against MCF-7 cell line ChEMBL. 15177442
IC50 (functional) = 4.9 nM Antiproliferative activity against MCF-7 cell line ChEMBL. 15177442
IC50 (functional) = 6.9 nM Antagonist activity at human wild type ERbeta expressed in HEK293T cells co-expressing ERE assessed as inhibition of estradiol-induced transactivation by luciferase reporter gene assay ChEMBL. 20659801
IC50 (binding) = 7 nM Binding to Estrogen receptor- alpha (ER alpha) receptor ChEMBL. 12270167
IC50 (binding) = 7 nM In vitro binding affinity for estrogen receptor alpha ChEMBL. 12749898
IC50 (binding) = 7 nM Binding to Estrogen receptor- alpha (ER alpha) receptor ChEMBL. 12270167
IC50 (binding) = 7 nM In vitro binding affinity for estrogen receptor alpha ChEMBL. 12749898
IC50 (binding) = 7.7 nM Displacement of [3H]-17-beta-estradiol from Estrogen receptor of rabbit uterine tissue ChEMBL. 11738564
IC50 (binding) = 7.7 nM Displacement of [3H]-17-beta-estradiol from Estrogen receptor of rabbit uterine tissue ChEMBL. 11738564
IC50 (binding) = 8.2 nM Binding affinity to ERbeta ChEMBL. 16722623
IC50 (binding) = 8.2 nM Binding affinity to ERbeta ChEMBL. 16722623
IC50 (binding) = 8.2 nM Inhibition of fluormone ES2 binding to estrogen receptor beta after 1 hr by fluorescence polarization assay ChEMBL. 19366247
IC50 (binding) = 12 nM Binding affinity towards human estrogen receptor beta (ERbeta) ChEMBL. 15109649
IC50 (binding) = 12 nM Binding affinity towards human recombinant Estrogen receptor beta was determined ChEMBL. 15084115
IC50 (binding) = 12 nM Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor beta ChEMBL. 15125925
IC50 (binding) = 12 nM Binding affinity for Human Estrogen receptor-beta ChEMBL. 12565955
IC50 (binding) = 12 nM Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay ChEMBL. 15006374
IC50 (binding) = 12 nM Inhibition of binding to recombinant human estrogen receptor beta ChEMBL. 15582421
IC50 (binding) = 12 nM Binding potency for human ER beta ChEMBL. 15225685
IC50 (binding) = 12 nM Binding potency for human ER beta ChEMBL. 15225686
IC50 (binding) = 12 nM Inhibition of binding to recombinant human ERbeta by scintillation proximity assay ChEMBL. 16203138
IC50 (binding) = 12 nM Binding affinity towards human estrogen receptor beta (ERbeta) ChEMBL. 15109649
IC50 (binding) = 12 nM Binding affinity towards human recombinant Estrogen receptor beta was determined ChEMBL. 15084115
IC50 (binding) = 12 nM Displacement of [3H]-17-beta-estradiol from full length human estrogen receptor beta ChEMBL. 15125925
IC50 (binding) = 12 nM Binding affinity for Human Estrogen receptor-beta ChEMBL. 12565955
IC50 (binding) = 12 nM Binding affinity against human estrogen receptor beta (ER beta) in competitive binding assay ChEMBL. 15006374
IC50 (binding) = 12 nM Inhibition of binding to recombinant human estrogen receptor beta ChEMBL. 15582421
IC50 (binding) = 12 nM Binding potency for human ER beta ChEMBL. 15225685
IC50 (binding) = 12 nM Binding potency for human ER beta ChEMBL. 15225686
IC50 (binding) = 12 nM Inhibition of binding to recombinant human ERbeta by scintillation proximity assay ChEMBL. 16203138
IC50 (binding) = 15 nM In vitro inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor beta ChEMBL. 12459017
IC50 (binding) = 15 nM In vitro inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor beta ChEMBL. 12459017
IC50 (binding) = 18.9 nM Inhibition of estrogen receptor beta ChEMBL. 15713417
IC50 (binding) = 18.9 nM Inhibition of estrogen receptor beta ChEMBL. 15713417
IC50 (binding) = 20.6 nM Displacement of [3H]estradiol from human recombinant ERalpha ChEMBL. 17489582
IC50 (binding) = 20.6 nM Displacement of [3H]estradiol from human recombinant ERalpha ChEMBL. 17489582
IC50 (binding) = 22 nM Inhibition of [3H]-estradiol binding to human estrogen receptor alpha expressed in HeLa cells ChEMBL. 15658851
IC50 (binding) = 22 nM Inhibition of [3H]-estradiol binding to human estrogen receptor alpha expressed in HeLa cells ChEMBL. 15658851
IC50 (functional) = 23 nM Inhibition of estrogen receptor in Ishikawa cells ChEMBL. 16722623
IC50 (functional) = 23 nM Inhibition of estrogen receptor in Ishikawa cells ChEMBL. 16722623
IC50 (functional) = 24 nM Antagonist activity at estrogen receptor in human Ishikawa cells assessed as 17-beta-estradiol-induced alkaline phosphatase activity after 3 days by chemiluminescence assay ChEMBL. 19366247
IC50 (binding) = 43 nM In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2 ChEMBL. 11356100
IC50 (binding) = 43 nM In vitro inhibitory concentration against [3H]-17-beta-estradiol binding to human estrogen receptor 2 ChEMBL. 11356100
IC50 (binding) = 170 nM Displacement of [3H]-estradiol from Estrogen receptor in MCF-7 cells ChEMBL. 1548683
IC50 (binding) = 170 nM Displacement of [3H]-estradiol from Estrogen receptor in MCF-7 cells ChEMBL. 1548683
IC50 (functional) = 222 nM Inhibition of estrogen receptor in MCF7 cells ChEMBL. 16722623
IC50 (functional) = 222 nM Inhibition of estrogen receptor in MCF7 cells ChEMBL. 16722623
IC50 (functional) = 222 nM Antagonist activity at estrogen receptor in human MCF7 cells assessed as 17-beta-estradiol-induced cell proliferation after 24 hrs by [14C]thymidine incorporation assay ChEMBL. 19366247
IC50 (binding) = 260 nM Inhibition of [3H]-estradiol binding to human estrogen receptor beta expressed in HeLa cells ChEMBL. 15658851
IC50 (binding) = 260 nM Inhibition of [3H]-estradiol binding to human estrogen receptor beta expressed in HeLa cells ChEMBL. 15658851
IC50 (binding) = 341 nM Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay ChEMBL. 15658851
IC50 (binding) = 341 nM Inhibition of 17-beta-estradiol mediated luciferase transcription in HeLa cells expressing human estrogen receptor beta; ERE assay ChEMBL. 15658851
IC50 (binding) = 470 nM Binding to Estrogen receptor- beta (ER beta) receptor ChEMBL. 12270167
IC50 (binding) = 470 nM In vitro binding affinity for estrogen receptor beta ChEMBL. 12749898
IC50 (binding) = 470 nM Binding to Estrogen receptor- beta (ER beta) receptor ChEMBL. 12270167
IC50 (binding) = 470 nM In vitro binding affinity for estrogen receptor beta ChEMBL. 12749898
IC50 (binding) = 557 nM Displacement of [3H]estradiol from human recombinant ERbeta ChEMBL. 17489582
IC50 (binding) = 557 nM Displacement of [3H]estradiol from human recombinant ERbeta ChEMBL. 17489582
IC50 (functional) = 2000 nM Inhibition of bone resorption in Rabbit osteoclast cells by Bone-pit assay ChEMBL. 12270167
IC50 (binding) = 3400 nM Inhibition of human PLD2 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay ChEMBL. 19136975
IC50 (binding) = 4300 nM Inhibition of human PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay ChEMBL. 19136975
IC50 (binding) = 8500 nM Inhibition of PLD1 in human Calu-1 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis ChEMBL. 19136975
IC50 (binding) = 10000 nM Inhibition of GFP-tagged human PLD2 expressed in human HEK293 cells assessed as decrease in phosphatidylbutanol-[d9] production after 30 mins by mass spectrometric analysis ChEMBL. 19136975
IC50 (binding) > 20000 nM Inhibition of N-terminally truncated rat PLD1 assessed as release of methyl-[3H]choline from choline-methyl-[3H]dipalmitoylphosphatidylcholine after 30 mins by exogenous substrate assay ChEMBL. 19136975
IC50 (ADMET) = 0.003 uM Inhibition of human aldehyde oxidase ChEMBL. 20853847
IC50 (ADMET) = 0.008 uM Inhibition of Homo sapiens (human) aldehyde oxidase ChEMBL. 21476569
IC50 (ADMET) = 0.5 uM Inhibition of mouse aldehyde oxidase ChEMBL. 20853847
IC50 (ADMET) = 0.5 uM Inhibition of monkey aldehyde oxidase ChEMBL. 20853847
IC50 (ADMET) = 1.1 uM Inhibition of rat aldehyde oxidase ChEMBL. 20853847
IC50 (binding) = 4 uM Inhibition of human PLD1b ChEMBL. 19136975
IC50 (functional) = 6.8 uM Cytotoxicity against mouse MG-22A cells after 72 hrs by MTT assay ChEMBL. 25282270
IC50 (binding) = 11.56 uM Antagonist activity at human GTS-tagged FXR after 20 mins by TR-FRET assay ChEMBL. 23688559
IC50 (functional) = 15.4 uM Antiproliferative activity against human MCF7 cells ChEMBL. 27155469
IC50 (binding) = 33 uM Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in absence of Triton X-100 ChEMBL. 20426472
IC50 (functional) = 50 uM Cytotoxicity against human MCF7 cells after 72 hrs by MTT assay ChEMBL. 25282270
IC50 (binding) > 60 uM Inhibition of Trypanosoma cruzi cruzain by quantitative high throughput screening ChEMBL. 19908840
IC50 (binding) = 128 uM Inhibition of Trypanosoma cruzi cruzaine preincubated for 5 mins before substrate addition by fluorescence assay in presence of 0.01% Triton X-100 ChEMBL. 20426472
IC50 (ADMET) = 1533 uM Inhibition of Oryctolagus cuniculus (rabbit) AOX in liver cytosol ChEMBL. 21476569
Increase (functional) = 2.4 % Effect on bone density in the lumber spine was determined in postmenopausal women ChEMBL. 12646017
Increase (functional) = 2.4 % Effect on bone density of totalhip was determined in postmenopausal women ChEMBL. 12646017
Increase (functional) = 2.4 % Effect on bone density in the lumber spine was determined in postmenopausal women ChEMBL. 12646017
Increase (functional) = 23.5 % Minimum effective dose at which significant increase in uterine weight/body weight in rat was determined (in vivo); expressed as % increase relative to ovariectomized (OVX) controls ChEMBL. 9003514
Inhibition (ADMET) Inhibition of human CYP2D6 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 4-methylaminoethyl-7-methoxycoumarin as substrate after 30 mins ChEMBL. 22931300
Inhibition (binding) Inhibition of delta 8-7 isomerase in mouse Neuro2a cells assessed as decrease in 7-DHC levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of DR24 in mouse Neuro2a cells assessed as decrease in 7-DHC levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of DR24 in Dhcr7-deficient mouse Neuro2a cells assessed as decrease in 7-DHC levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Antiestrogenic activity at ERalpha in estrogen-sensitive human T47D cells assessed as blockage of E2 stimulated cell proliferation at 0 LITERATURE. 27155470
Inhibition (ADMET) Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 shift assay ChEMBL. 21393461
Inhibition (binding) Inhibition of C-24 reductase in Dhcr7-deficient mouse Neuro2a cells assessed as increase in zymosterol levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of delta 8-7 isomerase in Dhcr7-deficient mouse Neuro2a cells assessed as decrease in 7-DHC levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of IL-6Ralpha/GP130 interaction in ER-negative human SUM159 cells overexpressing IL-6 assessed as inhibition of constitutive STAT3 phosphorylation at Y705 at 15 to 50 uM after 24 hrs by Western blot analysis ChEMBL. 24456369
Inhibition (binding) Inhibition of C-24 reductase in Dhcr7-deficient mouse Neuro2a cells assessed as increase in desmosterol levels at 1 uM by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of LIFR/GP130 interaction in human PANC-1 cells assessed as inhibition of LIF-induced STAT3 phosphorylation at Y705 at 25 uM after 24 hrs by Western blot analysis ChEMBL. 24456369
Inhibition (ADMET) Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis in presence of NADPH ChEMBL. 21393461
Inhibition (binding) Inhibition of IL-6Ralpha/GP130 interaction in human PANC-1 cells assessed as inhibition of IL-6-induced STAT3 phosphorylation at Y705 preincubated for 30 mins followed by IL-6 induction measured after 24 hrs by Western blot analysis ChEMBL. 24456369
Inhibition (binding) Inhibition of DR24 in human SLOS fibroblasts assessed as decrease in 7-DHC levels at 10 nM after 5 days by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (binding) Inhibition of delta 8-7 isomerase in human SLOS fibroblasts assessed as decrease in 7-DHC levels at 10 nM after 5 days by LC-MS/GC-MS analysis ChEMBL. 26789657
Inhibition (ADMET) Inhibition of human CYP1A2 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using ethoxyresorufin as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by refined CYP450 IC50 shift assay in presence of NADPH ChEMBL. 21393461
Inhibition (ADMET) Time dependent inhibition of CYP3A4 in human liver microsomes assessed as conversion of testosterone to 6beta-hydroxytestosterone at 0.01 to 100 uM preincubated for 60 mins followed by testosterone treatment measured after 10 mins by LC-MS/MS analysis ChEMBL. 21393461
Inhibition (ADMET) Inhibition of human CYP2C19 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 3-butyryl-7-methoxycoumarin as substrate after 30 mins ChEMBL. 22931300
Inhibition (ADMET) Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-benzyloxyquinoline as substrate after 30 mins ChEMBL. 22931300
Inhibition (binding) = 0 % Inhibition of IDO1 (unknown origin) at highest soluble concentration using L-tryptophan substrate incubated for 60 mins by HPLC ChEMBL. 25036789
Inhibition (functional) = 6 % Inhibition of Calmodulin activation of cyclic nucleotide phosphodiesterase ChEMBL. 1548683
Inhibition (binding) = 71.4 % Antagonist activity at human GTS-tagged FXR at 15 uM after 20 mins by TR-FRET assay ChEMBL. 23688559
Inhibition (binding) = 88 % Antagonist activity at human recombinant dopamine D2 long receptor expressed in CHOK1 cells coexpressing mitochondrial apoaequorin assessed as inhibition of agonist-induced effect at 50 uM after 15 mins by luminometric analysis relative to haloperidol ChEMBL. 24088053
Inhibition (functional) = 96 % Anti-estrogenic activity as percent inhibtion/control in uterotrophic assay on co-administration with subcutaneous 17-beta-estradiol in rats; 96/8 ChEMBL. 15109649
Inhibition (functional) = 96 % In vivo estrogenic activity in immature rat uterine weight assay at 0.6 mg/kg subcutaneous dose ChEMBL. 15006374
Inhibition (functional) = 96 % Anti-estrogenic activity as percent inhibtion/control in uterotrophic assay on co-administration with subcutaneous 17-beta-estradiol in rats; 96/8 ChEMBL. 15109649
Inhibition (functional) = 96 % In vivo estrogenic activity in immature rat uterine weight assay at 0.6 mg/kg subcutaneous dose ChEMBL. 15006374
Inhibition (functional) = 97 % Antagonist activity at human recombinant dopamine D1 receptor expressed in CHOK1 cells assessed as inhibition of agonist-induced cAMP accumulation at 100 uM preincubated for 10 mins prior to agonist addition measured after 30 mins by HTRF assay relative to SCH23390 ChEMBL. 24088053
Inhibition (binding) = 113 % Percent maximal inhibition of transcriptional activation stimulated by 1 nM 17 beta-estradiol in T47D cells expressing estrogen receptor alpha ChEMBL. 12459017
Inhibition (binding) = 113 % Percent maximal inhibition of transcriptional activation stimulated by 1 nM 17 beta-estradiol in T47D cells expressing estrogen receptor alpha ChEMBL. 12459017
Inhibition (binding) = 120 % Percent maximal inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor beta ChEMBL. 12459017
Inhibition (binding) = 120 % Percent maximal inhibition of 1 nM 17-beta-estradiol induced transcriptional activation in T47D cells expressing estrogen receptor beta ChEMBL. 12459017
Ki (ADMET) Uncompetitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as enzyme-substrate complex by Lineweaver-Burk plot analysis ChEMBL. 22996261
Ki (functional) = 0.03 nM Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol ChEMBL. 16162002
Ki (functional) = 0.03 nM Antagonistic activity against estrogen receptor alpha in presence of 0.1 nM estradiol ChEMBL. 16162002
Ki (binding) = 0.22 nM Ability to displace [3H]-17-beta-estradiol from Estrogen receptor alpha by scintillation proximity assay. ChEMBL. 11459665
Ki (binding) = 0.22 nM Ability to displace [3H]-17-beta-estradiol from Estrogen receptor alpha by scintillation proximity assay. ChEMBL. 11459665
Ki (binding) = 0.37 nM Displacement of [3H]estradiol from ERalpha after 4 hrs by scintillation counting ChEMBL. 22582136
Ki (binding) = 0.38 nM Binding affinity to ERalpha ligand binding domain ChEMBL. 22582136
Ki (binding) = 0.4 nM Binding affinity for estrogen receptor alpha ChEMBL. 12749895
Ki (binding) = 0.4 nM Binding affinity for estrogen receptor alpha ChEMBL. 12749895
Ki (binding) = 0.43 nM Binding affinity to ERalpha (unknown origin) ChEMBL. 26795112
Ki (binding) = 1 nM Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]-ifenprodil or (+)-[3H]-pentazocine as radioligand ChEMBL. 16033255
Ki (binding) = 1 nM Affinity for human EMP expressed in ERG2 deficient strain of Sacchromyces cerevisiae using [3H]-ifenprodil or (+)-[3H]-pentazocine as radioligand ChEMBL. 16033255
Ki (binding) = 2 nM Displacement of [3H]estradiol from full length biotinylated human ERalpha by scintillation proximity assay ChEMBL. 18722117
Ki (binding) = 2.74 nM Displacement of [3H]estradiol from ERbeta after 4 hrs by scintillation counting ChEMBL. 22582136
Ki (binding) = 4.3 nM Binding affinity for estrogen receptor beta ChEMBL. 12749895
Ki (binding) = 4.3 nM Binding affinity for estrogen receptor beta ChEMBL. 12749895
Ki (binding) = 4.3 nM Binding affinity to ERbeta (unknown origin) ChEMBL. 26795112
Ki (functional) = 4.5 nM Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol ChEMBL. 16162002
Ki (functional) = 4.5 nM Antagonistic activity against estrogen receptor beta in presence of 0.1 nM estradiol ChEMBL. 16162002
Ki (binding) = 10 nM Ability to displace [3H]-17-beta-estradiol from Estrogen receptor beta by scintillation proximity assay. ChEMBL. 11459665
Ki (binding) = 10 nM Ability to displace [3H]-17-beta-estradiol from Estrogen receptor beta by scintillation proximity assay. ChEMBL. 11459665
Ki (binding) = 23 nM Displacement of [3H]estradiol from full length biotinylated human ERbeta by scintillation proximity assay ChEMBL. 18722117
Ki (binding) = 38 nM Affinity for sigma receptor type 1 of guinea pig using [3H]-ifenprodil or (+)-[3H]-pentazocine radioligand ChEMBL. 16033255
Ki (binding) = 38 nM Affinity for sigma receptor type 1 of guinea pig using [3H]-ifenprodil or (+)-[3H]-pentazocine radioligand ChEMBL. 16033255
Ki (binding) = 66 nM Affinity for ERG2 of Sacchromyces cerevisiae using [3H]-ifenprodil or (+)-[3H]-pentazocine radioligand ChEMBL. 16033255
Ki (binding) = 66 nM Affinity for ERG2 of Sacchromyces cerevisiae using [3H]-ifenprodil or (+)-[3H]-pentazocine radioligand ChEMBL. 16033255
Ki (binding) = 69 nM Displacement of [3H]LSD from human cloned 5HT2B receptor expressed in CHO cells by liquid scintillation counting ChEMBL. 20958049
Ki (binding) = 750 nM Displacement of [3H]LSD from human 5HT6 receptor expressed in HEK293 cells after 1.5 hrs by liquid scintillation counting ChEMBL. 22537153
Ki (ADMET) = 0.00087 uM Uncompetitive inhibition of human liver cytosolic aldehyde oxidase using phthalazine as substrate assessed as enzyme-substrate complex by Lineweaver-Burk plot analysis ChEMBL. 22996261
Ki (ADMET) = 0.0009 uM Inhibition of human aldehyde oxidase ChEMBL. 20853847
Ki (ADMET) = 0.0023 uM Competitive inhibition of human liver cytosolic aldehyde oxidase using DACA as substrate assessed as free enzyme by Lineweaver-Burk plot analysis ChEMBL. 22996261
Ki (ADMET) = 9.9 uM Inhibition of CYP3A4 in human liver microsomes ChEMBL. 22409598
Kinact (ADMET) = 0.16 /min Inhibition of CYP3A4 in human liver microsomes ChEMBL. 22409598
logD (ADMET) = 1.08 Partition coefficient (logD6.5) ChEMBL. 10891117
max activation (binding) = 81.5 % Agonist activity at PXR (unknown origin) expressed in human HepG2 cells assessed as induction of CYP3A4 transactivation at 20 uM after 16 hrs by luciferase reporter gene assay ChEMBL. 23688559
Mean uterine weight (functional) = 28.9 mg The compound was tested for anti-uterotropic activity in immature rats(Dosage 1000 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 32.5 mg The compound was tested for anti-uterotropic activity in immature rats(Dosage 100 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 35.4 mg The compound was tested for uterotropic activity in immature rats(Dosage 1000 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 36.7 mg The compound was tested for anti-uterotropic activity in immature rats(Dosage 10 microg) ChEMBL. 6431104
Mean uterine weight (functional) = 42.2 mg The compound was tested for uterotropic activity in immature rats(Dosage 10 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 42.7 mg The compound was tested for uterotropic activity in immature rats(Dosage 100 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 48.6 mg The compound was tested for uterotropic activity in immature rats(Dosage 1 ug) ChEMBL. 6431104
Mean uterine weight (functional) = 48.7 mg The compound was tested for anti-uterotropic activity in immature rats(Dosage 1 ug) ChEMBL. 6431104
MED (functional) = 0.1 mg kg-1 Minimally effective dose(MED) (mg/kg body weight) at which a statistically significant (p<= 0.05) increase in uterine weight/body weight was observed ChEMBL. 9548817
MED (functional) = 0.1 mg kg-1 Minimum effective dose at which significant increase in uterine weight/body weight in rat was determined (in vivo) ChEMBL. 9003514
MED (functional) = 0.1 mg kg-1 Minimally effective dose(MED) (mg/kg body weight) at which a statistically significant (p<= 0.05) increase in uterine weight/body weight was observed ChEMBL. 9548817
MED (functional) > 10 mg kg-1 Minimally effective dose(MED) (mg/kg body weight) at which a significant increase in EPO activity was observed in rats ChEMBL. 9548817
MED (functional) > 10 mg kg-1 Minimum effective dose at which significant increase in uterine eosinophil peroxidase (EPO) activity in rat was determined (in vivo) ChEMBL. 9003514
ND (binding) 0 Transcriptional activation in HeLa cells expressing human estrogen receptor beta; No data ChEMBL. 11906280
ND (binding) 0 Transcriptional activation in HeLa cells expressing human Estrogen receptor alpha; No data ChEMBL. 11906280
pKa = 9 Ionization constant (pKa) ChEMBL. 10891117
Protection (functional) = 9.6 % Percent protection of bone mineral density in the distal femur of OVX rat at a dose of 0.01 mg/kg/day ChEMBL. 9003514
Protection (functional) = 50 % Percent protection of bone mineral density in the distal femur of OVX rat at a dose of 0.1 mg/kg/day ChEMBL. 9003514
Protection (functional) = 53.8 % Percent protection of bone mineral density in the distal femur of OVX rat at a dose of 10 mg/kg/day ChEMBL. 9003514
Protection (functional) = 57.7 % Percent protection of bone mineral density in the distal femur of OVX rat at a dose of 1 mg/kg/day ChEMBL. 9003514
Ratio (binding) = 0.015 Selectivity ratio for binding to estrogen receptor alpha compared to estrogen receptor beta ChEMBL. 12749898
Ratio (binding) = 3 Ratio of inhibitory activity against human estrogen receptors 2 and 1 ChEMBL. 15993065
Ratio (binding) = 7 IC50 ratio for binding to recombinant human estrogen receptors alpha and beta ChEMBL. 15582421
Ratio (binding) = 7 Selectivity ratio for ER beta to ER alpha receptor ChEMBL. 15225686
Ratio (binding) = 12 Selectivity ratio for binding to ER beta and ER alpha receptors ChEMBL. 15225685
Ratio (binding) = 25.9 IC50 ratio of binding to estrogen receptor beta and alpha ChEMBL. 15713417
Ratio (binding) = 0.015 Selectivity ratio for binding to estrogen receptor alpha compared to estrogen receptor beta ChEMBL. 12749898
Ratio (binding) = 0.05 Selectivity as ratio of IC50 for ER alpha to that of ER beta ChEMBL. 12459017
Ratio (binding) = 3 Ratio of inhibitory activity against human estrogen receptors 2 and 1 ChEMBL. 15993065
Ratio (binding) = 7 IC50 ratio for binding to recombinant human estrogen receptors alpha and beta ChEMBL. 15582421
Ratio (binding) = 7 Selectivity ratio for ER beta to ER alpha receptor ChEMBL. 15225686
Ratio (binding) = 12 Selectivity ratio for binding to ER beta and ER alpha receptors ChEMBL. 15225685
Ratio (binding) = 25.9 IC50 ratio of binding to estrogen receptor beta and alpha ChEMBL. 15713417
Ratio (binding) = 30 Selectivity for human ERbeta over human ERbeta ChEMBL. 17489582
Ratio IC50 (ADMET) = 2 Inhibition of human CYP3A4 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using diethoxyfluorescein as substrate after 30 mins ChEMBL. 22931300
Ratio IC50 (ADMET) < 2 Inhibition of human CYP2C9 assessed as ratio of IC50 in absence of NADPH to IC50 for presence of NADPH using 7-methoxy-4-trifluoromethylcoumarin-3-acetic acid as substrate after 30 mins ChEMBL. 22931300
Ratio IC50 (binding) = 7 Selectivity for human ERbeta over ERalpha ChEMBL. 16203138
Ratio IC50 (binding) = 7 Selectivity for human ERbeta over ERalpha ChEMBL. 16203138
Ratio Ki (ADMET) Ratio of Ki for uncompetitive inhibition of human liver cytosolic aldehyde oxidase to Ki for competitive inhibition of human liver cytosolic aldehyde oxidase ChEMBL. 22996261
RBA (binding) = 0.03 Displacement of [3H]estradiol from human recombinant ERbeta relative to estradiol ChEMBL. 17489582
RBA (binding) = 0.34 Displacement of [3H]-17-beta-estradiol from estrogen receptor of MCF-7 cell lysates relative to 17-beta-estradiol ChEMBL. 10098655
RBA (binding) = 0.34 Displacement of [3H]-17-beta-estradiol from estrogen receptor of MCF-7 cell lysate as relative binding affinity ChEMBL. 10328300
RBA (binding) = 0.34 Relative binding affinity of Estrogen receptor measured by using [3H]-17-beta-estradiol ChEMBL. 9548817
RBA (binding) = 0.34 In vitro relative binding affinity by competition with [3H]-17-beta-estradiol for estrogen receptor in MCF-7 cell lysate ChEMBL. 9003514
RBA (binding) = 0.34 Displacement of [3H]-estradiol from estrogen receptor ChEMBL. 22405286
RBA (binding) = 0.34 Relative binding affinity to estrogen receptor ChEMBL. 22405286
RBA (binding) = 0.91 Displacement of [3H]estradiol from human recombinant ERalpha relative to estradiol ChEMBL. 17489582
RBA (binding) = 35 Binding affinity against estrogen receptor alpha relative to E2 ChEMBL. 15177442
RBA (binding) = 0.03 Displacement of [3H]estradiol from human recombinant ERbeta relative to estradiol ChEMBL. 17489582
RBA (binding) = 0.34 Displacement of [3H]-17-beta-estradiol from estrogen receptor of MCF-7 cell lysates relative to 17-beta-estradiol ChEMBL. 10098655
RBA (binding) = 0.34 Relative binding affinity of Estrogen receptor measured by using [3H]-17-beta-estradiol ChEMBL. 9548817
RBA (binding) = 0.34 In vitro relative binding affinity by competition with [3H]-17-beta-estradiol for estrogen receptor in MCF-7 cell lysate ChEMBL. 9003514
RBA (binding) = 0.34 Displacement of [3H]-17-beta-estradiol from estrogen receptor of MCF-7 cell lysate as relative binding affinity ChEMBL. 10328300
RBA (binding) = 0.91 Displacement of [3H]estradiol from human recombinant ERalpha relative to estradiol ChEMBL. 17489582
RBA (binding) = 35 Binding affinity against estrogen receptor alpha relative to E2 ChEMBL. 15177442
RBA (binding) = 58 % Binding affinity to ERbeta ChEMBL. 16722623
RBA (binding) = 58 % Binding affinity to ERbeta ChEMBL. 16722623
RBA (binding) = 64 % Binding affinity to ERalpha ChEMBL. 16722623
RBA (binding) = 64 % Binding affinity to ERalpha ChEMBL. 16722623
RBA (binding) = 100 % Displacement of fluorescein labelled E2 from full length estrogen receptor alpha (unknown origin) after 2 hrs by fluorescence polarization assay relative to raloxifene ChEMBL. 26681208
Reduction (functional) = 49 % Percent cholesterol reduction in female ovariectomized rat at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Reduction (functional) = 49 % Percent cholesterol reduction in female ovariectomized rat at 1.5 mg/kg (for 6 weeks) ChEMBL. 15745820
Relative binding affinity (binding) = 1.8 % Binding affinity for Estrogen receptor in MCF-Cells relative to estradiol ChEMBL. 1548683
Relative binding affinity (binding) = 1.8 % Binding affinity for Estrogen receptor in MCF-Cells relative to estradiol ChEMBL. 1548683
Relative binding affinity (binding) = 4 nM Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiol; relative to 4-hydroxytamoxifen ChEMBL. 16162002
Relative binding affinity (binding) = 4 nM Binding affinity towards human estrogen receptor beta in a competitive binding assay using fluorescently labelled estradiol; relative to 4-hydroxytamoxifen ChEMBL. 16162002
Relative binding affinity (binding) = 18 nM Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol; relative to 4-hydroxytamoxifen ChEMBL. 16162002
Relative binding affinity (binding) = 18 nM Binding affinity towards human estrogen receptor alpha in a competitive binding assay using fluorescently labelled estradiol; relative to 4-hydroxytamoxifen ChEMBL. 16162002
Selectivity (binding) = 7 Selectivity was determined as ratio of IC50 against human ER alpha to that of human ER beta ChEMBL. 15006374
Selectivity (binding) = 7 Selectivity of IC50[ERbeta] / IC50[ERalpha] ChEMBL. 15109649
Selectivity (binding) = 67 Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor ChEMBL. 12270167
Selectivity (binding) = 7 Selectivity of IC50[ERbeta] / IC50[ERalpha] ChEMBL. 15109649
Selectivity (binding) = 7 Selectivity was determined as ratio of IC50 against human ER alpha to that of human ER beta ChEMBL. 15006374
Selectivity (binding) = 67 Selectivity as ratio of IC50 against ER beta receptor to IC50 against ER alpha receptor ChEMBL. 12270167
Stimulation (functional) = -33 % Agonist activity in MCF-7 breast tumor cell proliferation assay, based on pS2 gene expression at 10 uM ChEMBL. 12270167
Stimulation (functional) = -33 % Agonist activity in MCF-7 breast tumor cell proliferation assay, based on pS2 gene expression at 10 uM ChEMBL. 12270167
Stimulation (functional) = 94 % Antagonist activity in MCF-7 breast tumor cell proliferation assay, based on pS2 gene expression at 10 nM ChEMBL. 12270167
Stimulation (functional) = 94 % Antagonist activity in MCF-7 breast tumor cell proliferation assay, based on pS2 gene expression at 10 nM ChEMBL. 12270167
T/C (functional) = 0 % Cytostatic activity against human MCF7 cells at 5 uM after 3 days by microtiter assay ChEMBL. 20598555
TGI (functional) = 70 % Antitumor activity against mouse 4T1 cells allografted in BALB/c mouse assessed as tumor growth inhibition at 1.8 mg/kg, ip administered 24 hrs post tumor implantation on even days of total 9 doses for 18 days relative to control ChEMBL. 25282270
Transcriptional activation (binding) Transcriptional activation in HeLa cells expressing human estrogen receptor beta; No data ChEMBL. 11906280
Transcriptional activation (binding) Transcriptional activation in HeLa cells expressing human Estrogen receptor alpha; No data ChEMBL. 11906280
Uterine activity (functional) = 24 % Percent agonism of estradiol effects in rat uterine tissue at 1 mg/kg ChEMBL. 15225685
Uterine activity (functional) = 24 % Percent agonism of estradiol in rat uterine tissue at 1 mg/kg ChEMBL. 15225686
Uterine activity (functional) = 24 % Percent agonism of estradiol effects in rat uterine tissue at 1 mg/kg ChEMBL. 15225685
Uterine activity (functional) = 24 % Percent agonism of estradiol in rat uterine tissue at 1 mg/kg ChEMBL. 15225686
Uterine activity (functional) = 81 % Percent antagonism of estradiol effects in rat uterine tissue at 1 mg/kg ChEMBL. 15225685
Uterine activity (functional) = 81 % Percent antagonism of estradiol in rat uterine tissue at 1 mg/kg ChEMBL. 15225686
Uterine activity (functional) = 81 % Percent antagonism of estradiol effects in rat uterine tissue at 1 mg/kg ChEMBL. 15225685
Uterine activity (functional) = 81 % Percent antagonism of estradiol in rat uterine tissue at 1 mg/kg ChEMBL. 15225686
Uterine weight (functional) = 28.9 mg Uterine weight assay of ovx type raloxifene was determined invivo against estrogen receptor alpha ChEMBL. 15713417
Uterine weight (functional) = 52 mg Uterine weight assay of compound was determined invivo against estrogen receptor alpha ChEMBL. 15713417
Uterine weight (functional) = 203.4 mg Uterine weight assay of sham type raloxifene was determinedn invivo against estrogen receptor alpha ChEMBL. 15713417
Uterotrophic effect (functional) = 155 Uterotrophic effect as uterine weight gain in rats at 1 mg/kg/day oral dose for 4 days ChEMBL. 14643317
Uterotrophic effect (functional) = 155 Uterotrophic effect as uterine weight gain in rats at 1 mg/kg/day oral dose for 4 days ChEMBL. 14643317
Vss (ADMET) = 17.6 l kg-1 Steady state volume of distribution of the compound in rat after administration of 1 mg/kg (iv) and 5 mg/kg (po) ChEMBL. 15658851
Wet weight (functional) = 53.8 mg Uterine wet weight in ovariectomized mice after 4 weeks of subcutaneous administration at 4 umol/kg (n=5) ChEMBL. 15911274
Wet weight (functional) = 53.8 mg Uterine wet weight in ovariectomized mice after 4 weeks of subcutaneous administration at 4 umol/kg (n=5) ChEMBL. 15911274

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Mus musculus ChEMBL23 25282270
Homo sapiens ChEMBL23 11738564
Trypanosoma cruzi ChEMBL23 20547819
Saccharomyces cerevisiae ChEMBL23
Plasmodium falciparum ChEMBL23

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

68 literature references were collected for this gene.

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