Detailed information for compound 1000071

Basic information

Technical information
  • TDR Targets ID: 1000071
  • Name: 1-methoxy-9H-carbazole-3-carboxylic acid
  • MW: 241.242 | Formula: C14H11NO3
  • H donors: 2 H acceptors: 2 LogP: 2.88 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(cc2c1[nH]c1c2cccc1)C(=O)O
  • InChi: 1S/C14H11NO3/c1-18-12-7-8(14(16)17)6-10-9-4-2-3-5-11(9)15-13(10)12/h2-7,15H,1H3,(H,16,17)
  • InChiKey: VZOALRHIINZPKX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • NSC654276
  • NCI60_018840
  • AIDS-439565
  • AIDS439565
  • 9H-Carbazole-3-carboxylic acid, 1-methoxy-

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0451 0.0451
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0451 0.5
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Trypanosoma brucei protein kinase, putative 0.0052 1 1
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0052 1 1
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0052 1 1
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0451 0.5
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0052 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Onchocerca volvulus 0.0018 0 0.5
Echinococcus granulosus mitogen activated protein kinase 0.0052 1 1
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.4797 0.4797
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0451 0.5
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.9395 0.9395
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0451 0.0451
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0451 0.5
Echinococcus multilocularis mitogen activated protein kinase 3 0.0052 1 1
Schistosoma mansoni hypothetical protein 0.0034 0.4797 0.4797
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.9395 0.9395
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Schistosoma mansoni ap endonuclease 0.0019 0.0451 0.0451
Echinococcus multilocularis mitogen activated protein kinase 0.0052 1 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0451 1
Trichomonas vaginalis CMGC family protein kinase 0.0052 1 1
Schistosoma mansoni serine/threonine protein kinase 0.0052 1 1
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0052 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0451 0.0451
Schistosoma mansoni ap endonuclease 0.0019 0.0451 0.0451
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.9395 0.9395
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0451 1
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0052 1 1
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0052 1 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0451 0.5
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0451 0.0451
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0451 0.0451
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0052 1 1
Giardia lamblia Kinase, CMGC MAPK 0.0052 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.0451 0.0451
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0451 0.0451
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0451 0.0451
Echinococcus granulosus mitogen activated protein kinase 3 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.005 0.9395 0.9395
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0052 1 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.4797 0.4797

Activities

Activity type Activity value Assay description Source Reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SN12C Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the ACHN Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the UO-31 Renal cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HOP-92 Non-Small Cell Lung cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the HL-60(TB) Leukemia cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SK-MEL-5 Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the SF-539 Central Nervous System cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) -4.602 PUBCHEM_BIOASSAY: NCI human tumor cell line growth inhibition assay. Data for the MALME-3M Melanoma cell line. (Class of assay: confirmatory) ChEMBL. No reference
GI50 (functional) = 4.6 Growth inhibition of human CCRF-CEM cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human K562 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MOLT4 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SR cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human A549 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human EKVX cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HOP18 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HOP62 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HOP92 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human NCI-H226 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human NCI-H23 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human NCI-H322M cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human NCI-H460 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human NCI-H522 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human DMS273 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human COLO205 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human DLD1 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HCC2998 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HCT116 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HCT15 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HT29 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human KM12 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human KM20L2 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SW620 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SF268 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SF295 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SF539 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SNB19 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SNB75 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human U251 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human XF498 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human LOX IMVI cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MALME-3M cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human M14 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human M19-MEL cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SK-MEL-2 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SK-MEL-28 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SK-MEL-5 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human UACC257 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human UACC62 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human IGROV1 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SK-OV-3 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human 786-0 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human A498 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human ACHN cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human CAKI1 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human RFX393 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human SN12C cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human TK10 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human UO31 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human PC3 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human DU145 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MCF7 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MDA-MB-231 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human HS578T cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MDA-MB-435 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human MDA-N cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human BT549 cells ChEMBL. 10924160
GI50 (functional) = 4.6 Growth inhibition of human T47D cells ChEMBL. 10924160

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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