Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0024 | 0.0384 | 0.5463 |
Loa Loa (eye worm) | hypothetical protein | 0.0257 | 0.6607 | 0.6595 |
Mycobacterium leprae | Probable polyketide synthase Pks1 | 0.0026 | 0.0425 | 0.481 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0438 | 0.0389 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0126 | 0.009 |
Mycobacterium tuberculosis | Polyketide synthase Pks13 | 0.0036 | 0.0704 | 1 |
Onchocerca volvulus | Fatty acid synthase homolog | 0.0043 | 0.0902 | 1 |
Mycobacterium ulcerans | polyketide synthase | 0.0026 | 0.0425 | 0.481 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0383 | 1 | 1 |
Mycobacterium leprae | PROBABLE THIOESTERASE TESA | 0.002 | 0.0277 | 0.2064 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0026 | 0.0425 | 0.481 |
Toxoplasma gondii | beta-ketoacyl synthase, N-terminal domain-containing protein | 0.0016 | 0.0158 | 0.2574 |
Echinococcus granulosus | Smad4 | 0.0026 | 0.0438 | 0.1108 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC | 0.0026 | 0.0425 | 0.481 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0026 | 0.0425 | 1 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0384 | 0.4065 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3541 | 0.7963 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.3541 | 0.3518 |
Schistosoma mansoni | Smad4 | 0.0026 | 0.0438 | 0.0882 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.3541 | 0.3508 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.1912 | 0.5331 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsB | 0.0019 | 0.0258 | 0.172 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.3541 | 0.3518 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA | 0.0024 | 0.0384 | 0.4065 |
Echinococcus multilocularis | GPCR, family 2 | 0.0081 | 0.1912 | 0.5331 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0257 | 0.6607 | 0.6589 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsC | 0.0024 | 0.0384 | 0.5463 |
Mycobacterium leprae | Polyketide synthase Pks13 | 0.0036 | 0.0704 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0026 | 0.0438 | 0.0389 |
Mycobacterium ulcerans | polyketide synthase Pks13 | 0.0036 | 0.0704 | 1 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0081 | 0.1912 | 0.187 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsA | 0.0019 | 0.0258 | 0.172 |
Echinococcus multilocularis | TGF beta signal transducer SmadC | 0.0026 | 0.0438 | 0.1108 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.1912 | 0.5331 |
Echinococcus multilocularis | Smad4 | 0.0026 | 0.0438 | 0.1108 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.3541 | 1 |
Loa Loa (eye worm) | Smad1 | 0.0026 | 0.0438 | 0.0404 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0384 | 0.4065 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0081 | 0.1912 | 0.5331 |
Echinococcus granulosus | smad | 0.0026 | 0.0438 | 0.1108 |
Schistosoma mansoni | smad | 0.0026 | 0.0438 | 0.0882 |
Echinococcus granulosus | GPCR family 2 | 0.0081 | 0.1912 | 0.5331 |
Schistosoma mansoni | TGF-beta signal transducer Smad2 | 0.0026 | 0.0438 | 0.0882 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks8 | 0.002 | 0.0267 | 0.3792 |
Mycobacterium tuberculosis | Phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0384 | 0.5463 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3541 | 0.7963 |
Brugia malayi | Smad1 | 0.0026 | 0.0438 | 0.0389 |
Onchocerca volvulus | 0.0023 | 0.0342 | 0.3414 | |
Echinococcus granulosus | TGF beta signal transducer SmadC | 0.0026 | 0.0438 | 0.1108 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1912 | 0.4246 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0823 | 0.079 |
Mycobacterium tuberculosis | Probable multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0425 | 0.6033 |
Echinococcus multilocularis | smad | 0.0026 | 0.0438 | 0.1108 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0023 | 0.0342 | 0.4861 |
Mycobacterium tuberculosis | Probable membrane bound polyketide synthase Pks6 | 0.0036 | 0.0704 | 1 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0081 | 0.1912 | 0.5331 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.3541 | 0.3508 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1912 | 0.4246 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0026 | 0.0438 | 0.0404 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1912 | 0.4246 |
Loa Loa (eye worm) | AMP-binding enzyme family protein | 0.0023 | 0.0342 | 0.0307 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0438 | 0.0882 |
Loa Loa (eye worm) | nuclear factor I | 0.0014 | 0.0126 | 0.009 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.3541 | 1 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0126 | 0.0075 |
Brugia malayi | oxidoreductase, zinc-binding dehydrogenase family protein | 0.0046 | 0.0962 | 0.0916 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0175 | 0.4434 | 0.4405 |
Loa Loa (eye worm) | hypothetical protein | 0.0175 | 0.4434 | 0.4414 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0257 | 0.6607 | 0.6595 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0257 | 0.6607 | 0.6589 |
Schistosoma mansoni | hypothetical protein | 0.0175 | 0.4434 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0026 | 0.0438 | 0.0404 |
Loa Loa (eye worm) | hypothetical protein | 0.0014 | 0.0101 | 0.0065 |
Loa Loa (eye worm) | MH1 domain-containing protein | 0.0012 | 0.0051 | 0.0016 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks5 | 0.0023 | 0.0365 | 0.5182 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0081 | 0.1912 | 0.187 |
Mycobacterium tuberculosis | Polyketide synthase Pks2 | 0.0023 | 0.0365 | 0.5182 |
Mycobacterium ulcerans | polyketide synthase | 0.0024 | 0.0384 | 0.4065 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB | 0.0019 | 0.0258 | 0.172 |
Brugia malayi | Beta-ketoacyl synthase, N-terminal domain containing protein | 0.0024 | 0.0384 | 0.0335 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0438 | 0.0882 |
Loa Loa (eye worm) | fatty acid synthase | 0.0024 | 0.0376 | 0.0341 |
Mycobacterium tuberculosis | Probable thioesterase TesA | 0.002 | 0.0277 | 0.3934 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3541 | 0.7963 |
Echinococcus granulosus | mothers against decapentaplegic 5 | 0.0026 | 0.0438 | 0.1108 |
Mycobacterium ulcerans | multifunctional mycocerosic acid synthase membrane-associated Mas | 0.0026 | 0.0425 | 0.481 |
Mycobacterium leprae | Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas | 0.0026 | 0.0425 | 0.481 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0438 | 0.0389 |
Brugia malayi | RNA binding protein | 0.0142 | 0.3541 | 0.3508 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3541 | 0.7963 |
Mycobacterium tuberculosis | Polyketide synthase Pks12 | 0.0026 | 0.0425 | 0.6033 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.3541 | 0.7963 |
Loa Loa (eye worm) | hypothetical protein | 0.0012 | 0.0051 | 0.0016 |
Brugia malayi | MH2 domain containing protein | 0.0026 | 0.0438 | 0.0389 |
Schistosoma mansoni | smad1 5 8 and | 0.0026 | 0.0438 | 0.0882 |
Mycobacterium ulcerans | phenolpthiocerol synthesis type-I polyketide synthase PpsD | 0.0024 | 0.0384 | 0.4065 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0383 | 1 | 1 |
Echinococcus multilocularis | mothers against decapentaplegic 5 | 0.0026 | 0.0438 | 0.1108 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.3541 | 0.3518 |
Onchocerca volvulus | 0.0042 | 0.0862 | 0.9529 | |
Loa Loa (eye worm) | hypothetical protein | 0.0081 | 0.1912 | 0.1883 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks1 | 0.0017 | 0.0203 | 0.288 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks7 | 0.0026 | 0.0425 | 0.6033 |
Schistosoma mansoni | hypothetical protein | 0.0081 | 0.1912 | 0.4246 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0081 | 0.1912 | 0.1883 |
Mycobacterium ulcerans | thioesterase TesA | 0.002 | 0.0277 | 0.2064 |
Mycobacterium ulcerans | Type I modular polyketide synthase | 0.0024 | 0.0384 | 0.4065 |
Toxoplasma gondii | type I fatty acid synthase, putative | 0.0017 | 0.0198 | 0.3708 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0012 | 0.0051 | 0.0016 |
Mycobacterium tuberculosis | Probable polyketide synthase Pks9 | 0.0014 | 0.0106 | 0.1505 |
Brugia malayi | MH1 domain containing protein | 0.0014 | 0.0126 | 0.0075 |
Brugia malayi | AMP-binding enzyme family protein | 0.0023 | 0.0342 | 0.0292 |
Mycobacterium leprae | PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD | 0.0024 | 0.0384 | 0.4065 |
Mycobacterium ulcerans | thioesterase | 0.002 | 0.0277 | 0.2064 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.