Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | glucagon-like peptide 1 receptor | Starlite/ChEMBL | No references |
Homo sapiens | GNAS complex locus | Starlite/ChEMBL | No references |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Schistosoma mansoni | GTP-binding protein alpha subunit gna | GNAS complex locus | 394 aa | 450 aa | 28.7 % |
Loa Loa (eye worm) | pigment dispersing factor receptor c | glucagon-like peptide 1 receptor | 463 aa | 388 aa | 25.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | nuclear hormone receptor | 0.0034 | 0.0146 | 0.0149 |
Echinococcus multilocularis | hexokinase type 2 | 0.0089 | 0.0909 | 1 |
Onchocerca volvulus | 0.0089 | 0.0909 | 0.0774 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.006 | 0.0509 | 0.0522 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0068 | 0.007 |
Loa Loa (eye worm) | hexokinase type II | 0.0089 | 0.0909 | 0.0932 |
Loa Loa (eye worm) | hypothetical protein | 0.006 | 0.0509 | 0.0522 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.044 | 0.386 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Hexokinase family protein | 0.0089 | 0.0909 | 0.0932 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.044 | 0.386 |
Brugia malayi | Cytochrome P450 family protein | 0.0036 | 0.0172 | 0.0177 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.006 | 0.0509 | 0.0522 |
Brugia malayi | nuclear hormone receptor | 0.0729 | 0.9752 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | hexokinase type II | 0.0028 | 0.0068 | 0.007 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0023 | 0 | 0.5 |
Loa Loa (eye worm) | hexokinase | 0.0056 | 0.045 | 0.0461 |
Leishmania major | hexokinase, putative | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Hexokinase family protein | 0.0028 | 0.0058 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | nuclear receptor NHR-88 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0146 | 0.0149 |
Onchocerca volvulus | 0.0056 | 0.045 | 0.0308 | |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Echinococcus granulosus | hexokinase | 0.0089 | 0.0909 | 1 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.044 | 0.386 |
Loa Loa (eye worm) | follicle stimulating hormone receptor | 0.028 | 0.3543 | 0.3633 |
Echinococcus multilocularis | hexokinase | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0034 | 0.0146 | 0.0149 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0055 | 0.044 | 0.386 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0034 | 0.0146 | 0.0149 |
Entamoeba histolytica | hexokinase 1 | 0.0089 | 0.0909 | 0.5 |
Trypanosoma brucei | hexokinase | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0146 | 0.0149 |
Trypanosoma cruzi | hexokinase, putative | 0.0089 | 0.0909 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | hexokinase | 0.0089 | 0.0909 | 0.0932 |
Brugia malayi | follicle stimulating hormone receptor | 0.028 | 0.3543 | 0.3633 |
Schistosoma mansoni | hexokinase | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0517 | 0.053 |
Onchocerca volvulus | Hexokinase homolog | 0.0056 | 0.045 | 0.0308 |
Echinococcus granulosus | hexokinase | 0.0089 | 0.0909 | 1 |
Onchocerca volvulus | 0.0089 | 0.0909 | 0.0774 | |
Trypanosoma brucei | hexokinase | 0.0089 | 0.0909 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.044 | 0.386 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0055 | 0.044 | 0.0451 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | steroid hormone receptor | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | hexokinase | 0.0089 | 0.0909 | 0.0932 |
Plasmodium vivax | hexokinase, putative | 0.0089 | 0.0909 | 0.5 |
Plasmodium falciparum | hexokinase | 0.0089 | 0.0909 | 0.5 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Hexokinase family protein | 0.0056 | 0.045 | 0.0461 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0146 | 0.0149 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0034 | 0.0146 | 0.0149 |
Entamoeba histolytica | hexokinase 2 | 0.0089 | 0.0909 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0713 | 0.9531 | 0.9773 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.006 | 0.0509 | 0.0522 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0034 | 0.0146 | 0.0149 |
Schistosoma mansoni | hypothetical protein | 0.0041 | 0.0245 | 0.1309 |
Echinococcus multilocularis | hexokinase | 0.0089 | 0.0909 | 1 |
Trypanosoma brucei | hexokinase, putative | 0.0089 | 0.0909 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0034 | 0.0146 | 0.0149 |
Leishmania major | hexokinase, putative | 0.0089 | 0.0909 | 1 |
Treponema pallidum | hexokinase (hxk) | 0.0089 | 0.0909 | 0.5 |
Echinococcus multilocularis | hexokinase | 0.0089 | 0.0909 | 1 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0041 | 0.0245 | 0.0252 |
Trypanosoma cruzi | hexokinase, putative | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0034 | 0.0146 | 0.0149 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0055 | 0.044 | 0.386 |
Toxoplasma gondii | hexokinase | 0.0089 | 0.0909 | 0.5 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0055 | 0.044 | 0.0451 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.0245 | 0.0252 |
Onchocerca volvulus | 0.0089 | 0.0909 | 0.0774 | |
Loa Loa (eye worm) | nuclear receptor nhr-7B | 0.0729 | 0.9752 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0036 | 0.0172 | 0.0177 |
Echinococcus granulosus | hexokinase | 0.0089 | 0.0909 | 1 |
Loa Loa (eye worm) | hexokinase | 0.0028 | 0.0058 | 0.0059 |
Loa Loa (eye worm) | hypothetical protein | 0.0028 | 0.0068 | 0.007 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0055 | 0.044 | 0.386 |
Loa Loa (eye worm) | hypothetical protein | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | ecdysteroid receptor | 0.0034 | 0.0146 | 0.0149 |
Brugia malayi | hexokinase | 0.0089 | 0.0909 | 0.0932 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0034 | 0.0146 | 0.0149 |
Echinococcus granulosus | hexokinase type 2 | 0.0089 | 0.0909 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Potency (functional) | 7.9433 uM | PubChem BioAssay. qHTS for Agonist of gsp, the Etiologic Mutation Responsible for Fibrous Dysplasia/McCune-Albright Syndrome: qHTS. (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 12.5893 uM | PubChem BioAssay. qHTS of GLP-1 Receptor Inverse Agonists (Inhibition Mode). (Class of assay: confirmatory) | ChEMBL. | No reference |
Potency (functional) | 56.2341 uM | PUBCHEM_BIOASSAY: HTS for Inhibitors of HP1-beta Chromodomain Interactions with Methylated Histone Tails. (Class of assay: confirmatory) [Related pubchem assays (depositor defined):AID488962] | ChEMBL. | No reference |
Potency (functional) | 125.8925 uM | PubChem BioAssay. qHTS of PTHR Inhibitors: Primary Screen. (Class of assay: confirmatory) | ChEMBL. | No reference |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.