Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | tar DNA binding protein | 0.0073 | 0.1119 | 0.1119 |
Onchocerca volvulus | 0.0275 | 0.6732 | 1 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1119 | 0.3155 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0035 | 0.0036 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0057 | 0.067 | 0.11 |
Brugia malayi | TAR-binding protein | 0.0073 | 0.1119 | 0.1879 |
Loa Loa (eye worm) | TAR-binding protein | 0.0073 | 0.1119 | 0.1879 |
Brugia malayi | RNA binding protein | 0.0073 | 0.1119 | 0.1879 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.3469 | 1 |
Plasmodium vivax | SET domain protein, putative | 0.0035 | 0.0036 | 0.5 |
Echinococcus multilocularis | tumor protein p63 | 0.0392 | 1 | 1 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0073 | 0.1119 | 0.1879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1119 | 0.3155 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0241 | 0.5802 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.0241 | 0.5802 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0158 | 0.3469 | 0.3446 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1119 | 0.3155 |
Echinococcus multilocularis | tar DNA binding protein | 0.0073 | 0.1119 | 0.1087 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0146 | 0.3142 | 0.3118 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0073 | 0.1119 | 0.1879 |
Onchocerca volvulus | 0.0057 | 0.067 | 0.0947 | |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1119 | 0.3155 |
Schistosoma mansoni | tar DNA-binding protein | 0.0073 | 0.1119 | 0.3155 |
Schistosoma mansoni | thyroid hormone receptor | 0.0158 | 0.3469 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0146 | 0.3142 | 0.9048 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0035 | 0.0036 | 0.0036 |
Loa Loa (eye worm) | RNA binding protein | 0.0073 | 0.1119 | 0.1879 |
Trichomonas vaginalis | set domain proteins, putative | 0.0275 | 0.6732 | 0.5 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0057 | 0.067 | 0.1847 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0146 | 0.3142 | 0.3142 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
EC50 (functional) | = 5.8 uM | Induction of apoptosis in human T47D cells measured after 48 hrs by cell and caspase based HTS assay | ChEMBL. | 19467598 |
EC50 (functional) | > 10 uM | Induction of apoptosis in human HCT116 cells measured after 48 hrs by cell and caspase based HTS assay | ChEMBL. | 19467598 |
EC50 (functional) | > 10 uM | Induction of apoptosis in human SNU398 cells measured after 48 hrs by cell and caspase based HTS assay | ChEMBL. | 19467598 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 19467598 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.