Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | FTZ F1 alpha | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 nuclear receptor protein | 0.0016 | 1 | 1 |
Echinococcus multilocularis | FTZ F1 alpha | 0.0016 | 1 | 1 |
Echinococcus granulosus | retinoic acid receptor rxr beta a | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-1 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor-like 1 | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.5766 | 0.5766 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-31 | 0.0016 | 1 | 1 |
Schistosoma mansoni | coup transcription factor | 0.0016 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 1 | 1 |
Echinococcus multilocularis | COUP TF:Svp nuclear hormone receptor | 0.0016 | 1 | 1 |
Onchocerca volvulus | Protein ultraspiracle homolog | 0.0016 | 1 | 0.5 |
Onchocerca volvulus | Steroid hormone receptor family member cnr14 homolog | 0.0016 | 1 | 0.5 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Brugia malayi | steroid hormone receptor | 0.0016 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-49 | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | CYP4Cod1 | 0.0012 | 0.5766 | 0.5766 |
Schistosoma mansoni | Tr4/Tr2 (homologue) | 0.0016 | 1 | 1 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-14 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-40 | 0.0016 | 1 | 1 |
Onchocerca volvulus | Bile acid receptor homolog | 0.0016 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-1 | 0.0016 | 1 | 1 |
Schistosoma mansoni | RAR-like nuclear receptor | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 1 | 1 |
Schistosoma mansoni | retinoic acid receptor RXR | 0.0016 | 1 | 1 |
Echinococcus granulosus | FTZ F1 nuclear receptor protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Echinococcus granulosus | COUP TF:Svp nuclear hormone receptor | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-14 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-41 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-31 | 0.0016 | 1 | 1 |
Schistosoma mansoni | nuclear receptor 2DBD-gamma | 0.0016 | 1 | 1 |
Echinococcus granulosus | Nuclear hormone receptor family member nhr 41 | 0.0016 | 1 | 1 |
Echinococcus multilocularis | Nuclear hormone receptor family member nhr 41 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-25 | 0.0016 | 1 | 1 |
Echinococcus multilocularis | nuclear receptor 2DBD gamma | 0.0016 | 1 | 1 |
Schistosoma mansoni | retinoid-x-receptor (RXR) | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0009 | 0.0885 | 0.0885 |
Brugia malayi | nuclear hormone receptor | 0.0016 | 1 | 1 |
Brugia malayi | Ligand-binding domain of nuclear hormone receptor family protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Echinococcus multilocularis | ecdysone induced protein 78C | 0.0016 | 1 | 1 |
Echinococcus granulosus | ecdysone induced protein 78C | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-40 | 0.0016 | 1 | 1 |
Schistosoma mansoni | thyroid hormone receptor | 0.0016 | 1 | 1 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.5766 | 0.5766 |
Brugia malayi | Nuclear hormone receptor family member nhr-3 | 0.0016 | 1 | 1 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.5766 | 0.5 |
Echinococcus multilocularis | hepatocyte nuclear factor 4 alpha | 0.0016 | 1 | 1 |
Onchocerca volvulus | 0.0016 | 1 | 0.5 | |
Trypanosoma brucei | cytochrome P450, putative | 0.0012 | 0.5766 | 0.5 |
Brugia malayi | Cytochrome P450 family protein | 0.0012 | 0.5766 | 0.5766 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Leishmania major | cytochrome p450-like protein | 0.0012 | 0.5766 | 0.5 |
Loa Loa (eye worm) | nuclear hormone receptor family member nhr-41 | 0.0016 | 1 | 1 |
Mycobacterium ulcerans | cytochrome P450 185A4 Cyp185A4 | 0.0012 | 0.5766 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor nor-1/nor-2 | 0.0016 | 1 | 1 |
Echinococcus granulosus | hepatocyte nuclear factor 4 alpha | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | steroid hormone receptor | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | cytochrome P450 family protein | 0.0012 | 0.5766 | 0.5766 |
Trypanosoma cruzi | cytochrome P450, putative | 0.0012 | 0.5766 | 0.5 |
Schistosoma mansoni | nuclear hormone receptor | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-49 | 0.0016 | 1 | 1 |
Brugia malayi | Nuclear hormone receptor family member nhr-19 | 0.0016 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | nuclear Hormone Receptor family member | 0.0016 | 1 | 1 |
Brugia malayi | photoreceptor-specific nuclear receptor | 0.0016 | 1 | 1 |
Schistosoma mansoni | steroid hormone receptor ad4bp | 0.0016 | 1 | 1 |
Brugia malayi | nuclear receptor NHR-88 | 0.0016 | 1 | 1 |
Schistosoma mansoni | FTZ-F1 nuclear receptor-like protein | 0.0016 | 1 | 1 |
Schistosoma mansoni | photoreceptor-specific nuclear receptor related | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0016 | 1 | 1 |
Echinococcus granulosus | nuclear receptor 2DBD gamma | 0.0016 | 1 | 1 |
Brugia malayi | Steroid receptor seven-up type 2 | 0.0016 | 1 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 16 % | Inhibition of bovine lens ALR2 at 12.5 uM assessed as reduction of D,L-glyceraldehyde by spectrophotometry | ChEMBL. | 18492610 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.