Detailed information for compound 1001029

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1912.2 | Formula: C85H126N26O21S2
  • H donors: 26 H acceptors: 22 LogP: -7.22 Rotable bonds: 80
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H]1NC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@H](CS)NC(=O)[C@H](CC(C)C)NC(=O)[C@@H](NC(=O)[C@H](C)NC(=O)[C@@H](NC(=O)[C@H](CCC(=O)O)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)CNC(=O)[C@@H](NC1=O)CCCCN)C)CS)CCC(=O)O)C)CCCNC(=N)N)Cc1[nH]cnc1)Cc1c[nH]c2c1cccc2)Cc1c[nH]c2c1cccc2
  • InChi: 1S/C85H126N26O21S2/c1-42(2)31-60-80(128)111-64(39-133)83(131)100-44(4)69(117)97-45(5)71(119)101-56(22-13-15-29-87)76(124)103-55(21-12-14-28-86)74(122)94-38-66(112)96-43(3)70(118)110-65(40-134)84(132)105-58(24-26-67(113)114)75(123)98-46(6)72(120)102-57(23-16-30-91-85(88)89)77(125)109-63(34-50-37-90-41-95-50)82(130)104-59(25-27-68(115)116)78(126)108-61(32-48-35-92-53-19-10-8-17-51(48)53)79(127)99-47(7)73(121)106-62(81(129)107-60)33-49-36-93-54-20-11-9-18-52(49)54/h8-11,17-20,35-37,41-47,55-65,92-93,133-134H,12-16,21-34,38-40,86-87H2,1-7H3,(H,90,95)(H,94,122)(H,96,112)(H,97,117)(H,98,123)(H,99,127)(H,100,131)(H,101,119)(H,102,120)(H,103,124)(H,104,130)(H,105,132)(H,106,121)(H,107,129)(H,108,126)(H,109,125)(H,110,118)(H,111,128)(H,113,114)(H,115,116)(H4,88,89,91)/t43-,44-,45-,46-,47-,55-,56-,57-,58-,59-,60-,61-,62-,63-,64-,65-/m0/s1
  • InChiKey: AJOJPYLZVBQXGM-DLMQIZPQSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Chlamydia trachomatis oxoacyl-ACP synthase III 0.0311 0.4455 1
Echinococcus multilocularis muscleblind protein 1 0.0146 0.1959 0.1959
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0049
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0418 0.0417
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0273 0.1137
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0418 0.1933
Echinococcus granulosus fetal alzheimer antigen falz 0.0024 0.0097 0.0097
Echinococcus granulosus peregrin 0.0031 0.0206 0.0206
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0049
Loa Loa (eye worm) CXXC zinc finger family protein 0.0028 0.0164 0.0761
Brugia malayi Cytochrome P450 family protein 0.0032 0.0228 0.0929
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0035 0.0272 0.0271
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0024 0.0097 0.0097
Loa Loa (eye worm) cytochrome P450 family protein 0.0032 0.0228 0.1057
Loa Loa (eye worm) PHD-finger family protein 0.002 0.0044 0.0204
Entamoeba histolytica acyl-coA synthetase, putative 0.0024 0.0103 0.004
Entamoeba histolytica fatty acid elongase, putative 0.004 0.035 0.0658
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Loa Loa (eye worm) hypothetical protein 0.0064 0.0714 0.3304
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.216 0.216
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0103 0.0341
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.1863 0.4272
Schistosoma mansoni bromodomain containing protein 0.0064 0.0703 0.0703
Brugia malayi jmjC domain containing protein 0.0025 0.011 0.0375
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0062 0.0679 0.3145
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.003 0.003
Entamoeba histolytica fatty acid elongase, putative 0.004 0.035 0.0658
Loa Loa (eye worm) hypothetical protein 0.0069 0.0789 0.3653
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0275 0.0443
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4229 1
Leishmania major hypothetical protein, conserved 0.0035 0.0273 0.0411
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0103 0.004
Schistosoma mansoni jumonji domain containing protein 0.0025 0.011 0.011
Schistosoma mansoni rab6-interacting 0.0019 0.003 0.003
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0171 0.114
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0478
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.006 0.064 0.1417
Brugia malayi jmjC domain containing protein 0.0096 0.1189 0.5442
Brugia malayi Glycosyl hydrolases family 31 protein 0.016 0.216 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0096 0.1189 0.5506
Mycobacterium ulcerans hypothetical protein 0.0156 0.2103 0.4708
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0275 0.0443
Echinococcus multilocularis intestinal type alkaline phosphatase 1 0.0159 0.2156 0.2156
Mycobacterium ulcerans lipase LipD 0.0035 0.0273 0.059
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0035 0.0273 0.059
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0054 0.0558 0.0558
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0103 0.0208
Schistosoma mansoni rab6-interacting 0.0019 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Onchocerca volvulus 0.0024 0.0103 0.0656
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0035 0.0273 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0273 0.0394
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Brugia malayi Muscleblind-like protein 0.0146 0.1959 0.9054
Schistosoma mansoni hypothetical protein 0.002 0.0044 0.0044
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Brugia malayi F/Y-rich N-terminus family protein 0.002 0.0038 0.0035
Toxoplasma gondii aldehyde dehydrogenase 0.006 0.064 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0273 0.0438
Schistosoma mansoni cpg binding protein 0.0032 0.0217 0.0217
Mycobacterium tuberculosis Conserved protein 0.0035 0.0273 0.059
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1863 0.4255
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0275 0.0416
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0171 0.036
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0679 0.0679
Entamoeba histolytica hypothetical protein 0.0039 0.0332 0.0613
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0025 0.011 0.011
Onchocerca volvulus 0.0035 0.0273 0.2186
Plasmodium vivax multidomain scavenger receptor, putative 0.0019 0.003 0.0045
Entamoeba histolytica fatty acid elongase, putative 0.004 0.035 0.0658
Loa Loa (eye worm) hypothetical protein 0.0024 0.0098 0.0455
Loa Loa (eye worm) hypothetical protein 0.0146 0.1959 0.9068
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0049
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0103 0.0208
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0103 0.0208
Brugia malayi CXXC zinc finger family protein 0.0028 0.0164 0.0629
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0418 0.0417
Echinococcus granulosus cpg binding protein 0.0032 0.0217 0.0217
Schistosoma mansoni phd/f-box containing protein 0.0025 0.011 0.011
Schistosoma mansoni microtubule-associated protein tau 0.0677 1 1
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0369 0.0627
Trypanosoma brucei glucosidase, putative 0.0035 0.0275 0.0428
Echinococcus multilocularis zinc finger protein 0.0021 0.0053 0.0053
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0275 0.0399
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0171 0.114
Entamoeba histolytica hypothetical protein 0.0039 0.0332 0.0613
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0024 0.0103 0.0208
Echinococcus granulosus RUN 0.0019 0.003 0.003
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Echinococcus granulosus alkaline phosphatase 0.0159 0.2156 0.2156
Echinococcus granulosus jumonji domain containing 1A 0.0025 0.011 0.011
Plasmodium falciparum JmjC domain-containing protein, putative 0.0025 0.011 0.0225
Echinococcus granulosus phospholipase A 2 activating protein 0.0035 0.0273 0.0273
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0273 0.059
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0273 0.0273
Brugia malayi RNA binding protein 0.0062 0.0679 0.3047
Mycobacterium ulcerans beta-lactamase 0.0035 0.0273 0.059
Echinococcus granulosus JmjC domain containing protein 4 0.0025 0.011 0.011
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.064 0.1417
Brugia malayi PHD-finger family protein 0.0026 0.0132 0.0477
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.014 0.1861 0.4162
Trichomonas vaginalis penicillin-binding protein, putative 0.0035 0.0273 0.0438
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.064 0.064
Echinococcus multilocularis jumonji domain containing protein 0.004 0.0341 0.034
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0035 0.0272 0.0271
Giardia lamblia Fructose-bisphosphate aldolase 0.0287 0.4084 1
Brugia malayi jmjC domain containing protein 0.0025 0.011 0.0375
Schistosoma mansoni jumonji domain containing protein 0.0132 0.174 0.174
Loa Loa (eye worm) RNA binding protein 0.0062 0.0679 0.3145
Mycobacterium tuberculosis Probable esterase LipL 0.0035 0.0273 0.059
Plasmodium vivax JmjC domain containing protein 0.0025 0.011 0.0225
Brugia malayi TAR-binding protein 0.0062 0.0679 0.3047
Plasmodium vivax beta-ketoacyl-acyl carrier protein synthase III precursor, putative 0.0311 0.4455 1
Schistosoma mansoni transcription factor LCR-F1 0.0039 0.0332 0.0332
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0507 0.2236
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0025 0.011 0.003
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0151 0.2032 0.2032
Loa Loa (eye worm) hypothetical protein 0.0025 0.011 0.0511
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0275 0.3104
Mycobacterium ulcerans hypothetical protein 0.0024 0.0103 0.0208
Echinococcus multilocularis lysine specific demethylase 5A 0.0092 0.1137 0.1137
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0035 0.0273 0.059
Echinococcus granulosus zinc finger protein 0.0021 0.0053 0.0053
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4084 1
Onchocerca volvulus 0.0092 0.1139 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.016 0.216 0.216
Trichomonas vaginalis esterase, putative 0.0035 0.0273 0.0438
Brugia malayi Bromodomain containing protein 0.0075 0.0877 0.3975
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0275 0.0443
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0273 0.1262
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0311 0.4455 1
Schistosoma mansoni hypothetical protein 0.0019 0.003 0.003
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.011 0.0511
Echinococcus granulosus intestinal type alkaline phosphatase 1 0.0159 0.2156 0.2156
Onchocerca volvulus Alhambra homolog 0.0029 0.0171 0.1267
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0024 0.0103 0.0208
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.011 0.0511
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.064 0.1417
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0275 0.0443
Echinococcus granulosus muscleblind protein 0.0146 0.1959 0.1959
Trypanosoma brucei hypothetical protein, conserved 0.0035 0.0273 0.0422
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.016 0.216 1
Leishmania major mitochondrial DNA polymerase beta 0.0296 0.4229 1
Echinococcus multilocularis cpg binding protein 0.0032 0.0217 0.0217
Brugia malayi jmjC domain containing protein 0.0025 0.011 0.0375
Loa Loa (eye worm) hypothetical protein 0.0146 0.1959 0.9068
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0273 0.0438
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0171 0.0791
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0478
Leishmania major hypothetical protein, conserved 0.0025 0.011 0.0018
Echinococcus granulosus tar DNA binding protein 0.0062 0.0679 0.0679
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.003 0.003
Schistosoma mansoni alpha-glucosidase 0.0138 0.1823 0.1823
Loa Loa (eye worm) jmjC domain-containing protein 0.0059 0.0633 0.2928
Mycobacterium leprae conserved hypothetical protein 0.0035 0.0273 0.0965
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Schistosoma mansoni loxhd1 0.0019 0.003 0.003
Echinococcus multilocularis peregrin 0.0031 0.0206 0.0206
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0679 0.0679
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0311 0.4455 0.5
Schistosoma mansoni hypothetical protein 0.0029 0.0171 0.0171
Loa Loa (eye worm) hypothetical protein 0.0029 0.0171 0.0791
Schistosoma mansoni phosphatidylserine receptor 0.0025 0.011 0.011
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0024 0.0103 0.0208
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0275 0.0443
Echinococcus granulosus neuropeptide s receptor 0.0453 0.6614 0.6614
Brugia malayi hypothetical protein 0.0039 0.0332 0.1417
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0028 0.0163 0.0163
Brugia malayi beta-lactamase family protein 0.0035 0.0273 0.1137
Loa Loa (eye worm) hypothetical protein 0.0017 0 0.0001
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0028 0.0163 0.0163
Schistosoma mansoni alkaline phosphatase 0.0159 0.2156 0.2156
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0103 0.0341
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0418 0.0417
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0273 0.0395
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0024 0.0103 0.0208
Echinococcus granulosus alkaline phosphatase intestinal gene 2 0.0159 0.2156 0.2156
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0039 0.0332 0.0332
Schistosoma mansoni aldehyde dehydrogenase 0.006 0.064 0.064
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0035 0.0273 0.059
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0024 0.0103 0.0208
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0679 0.0679
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0275 0.047
Echinococcus granulosus Polycystic kidney disease protein 0.0019 0.003 0.003
Schistosoma mansoni lipoxygenase 0.0019 0.003 0.003
Echinococcus multilocularis JmjC domain containing protein 4 0.0025 0.011 0.011
Echinococcus granulosus intestinal type alkaline phosphatase 0.0159 0.2156 0.2156
Echinococcus multilocularis neuropeptide s receptor 0.0453 0.6614 0.6614
Loa Loa (eye worm) hypothetical protein 0.0035 0.0263 0.1218
Toxoplasma gondii ABC1 family protein 0.0035 0.0273 0.3062
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0507 0.2236
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0275 0.1273
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0649
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.3158 0.7082
Echinococcus multilocularis phospholipase A 2 activating protein 0.0035 0.0273 0.0273
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0171 0.0171
Mycobacterium tuberculosis Conserved protein 0.0035 0.0273 0.059
Echinococcus granulosus phd:f box containing protein 0.0025 0.011 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0273 0.0438
Loa Loa (eye worm) jmjC domain-containing protein 0.0025 0.011 0.0511
Onchocerca volvulus 0.0035 0.0273 0.2186
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0024 0.0103 0.0208
Brugia malayi Bromodomain containing protein 0.0031 0.0206 0.0824
Schistosoma mansoni lipoxygenase 0.0054 0.0558 0.0558
Toxoplasma gondii hypothetical protein 0.0048 0.0462 0.6629
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0275 0.0443
Brugia malayi AMP-binding enzyme family protein 0.0024 0.0103 0.0341
Echinococcus granulosus lysine specific demethylase 6a 0.0025 0.011 0.011
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.1863 0.4266
Mycobacterium tuberculosis Probable hydrolase 0.0035 0.0273 0.059
Schistosoma mansoni cpg binding protein 0.0032 0.0217 0.0217
Echinococcus granulosus lipoxygenase domain containing protein 0.0019 0.003 0.003
Onchocerca volvulus 0.0028 0.0164 0.1208
Mycobacterium leprae Probable lipase LipE 0.0035 0.0273 0.0965
Plasmodium falciparum polyubiquitin binding protein, putative 0.0035 0.0273 0.0591
Schistosoma mansoni zinc finger protein 0.0021 0.0053 0.0053
Mycobacterium ulcerans beta-ketoacyl synthase-like protein 0.0311 0.4455 1
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0049
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0296 0.4229 1
Brugia malayi beta-lactamase 0.0035 0.0273 0.1137
Mycobacterium ulcerans esterase/lipase LipP 0.0035 0.0273 0.059
Echinococcus granulosus lysine specific demethylase 5A 0.0096 0.1189 0.1189
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0507 0.2345
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0042 0.0369 0.0655
Loa Loa (eye worm) beta-lactamase 0.0035 0.0273 0.1262
Mycobacterium tuberculosis Probable lipase LipD 0.0035 0.0273 0.059
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0273 0.0273
Mycobacterium ulcerans 3-oxoacyl-ACP synthase 0.0311 0.4455 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Brugia malayi Bromodomain containing protein 0.0038 0.0307 0.1298
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0275 0.0399
Mycobacterium tuberculosis Conserved protein 0.0035 0.0273 0.059
Brugia malayi beta-lactamase family protein 0.0035 0.0273 0.1137
Entamoeba histolytica fatty acid elongase, putative 0.004 0.035 0.0658
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0275 0.1148
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0273 0.0273
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0039 0.0332 0.0332
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0263 0.1093
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.006 0.064 0.1302
Echinococcus multilocularis microtubule associated protein 2 0.0677 1 1
Echinococcus multilocularis tar DNA binding protein 0.0062 0.0679 0.0679
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0582 0.8893
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0287 0.4084 1
Loa Loa (eye worm) hypothetical protein 0.0025 0.011 0.0511
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0042 0.0369 0.0627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0418 0.1817
Echinococcus multilocularis neuropeptide receptor A26 0.0453 0.6614 0.6614
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0273 0.0273
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.006 0.064 0.064
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.006 0.0649 0.0649
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.014 0.1861 0.4162
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0024 0.0097 0.0097
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0054 0.0558 0.0558
Echinococcus multilocularis lipoxygenase domain containing protein 0.0019 0.003 0.003
Brugia malayi RNA recognition motif domain containing protein 0.0062 0.0679 0.3047
Mycobacterium tuberculosis 3-oxoacyl-[acyl-carrier-protein] synthase III FabH (beta-ketoacyl-ACP synthase III) (KAS III) 0.0311 0.4455 1
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0296 0.4229 1
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0141
Schistosoma mansoni protein phosphatase 2C 0.0025 0.011 0.011
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0042 0.0369 0.0627
Loa Loa (eye worm) doublecortin family protein 0.0019 0.003 0.0141
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.014 0.1861 1
Treponema pallidum fructose-bisphosphate aldolase 0.0287 0.4084 0.5
Schistosoma mansoni polycystin 1-related 0.0019 0.003 0.003
Echinococcus multilocularis muscleblind protein 0.0146 0.1959 0.1959
Echinococcus multilocularis RUN 0.0019 0.003 0.003
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0418 0.0417
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0679 0.0679
Mycobacterium tuberculosis Conserved hypothetical protein 0.0156 0.2103 0.4708
Echinococcus multilocularis alkaline phosphatase 0.0159 0.2156 0.2156
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0418 0.0417
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.006 0.064 0.064
Brugia malayi jmjC domain containing protein 0.0025 0.011 0.0375
Brugia malayi PHD-finger family protein 0.0029 0.0171 0.0659
Echinococcus multilocularis jumonji domain containing 1A 0.0025 0.011 0.011
Loa Loa (eye worm) hypothetical protein 0.0018 0.0011 0.0049
Loa Loa (eye worm) hypothetical protein 0.0024 0.0103 0.0478
Entamoeba histolytica hypothetical protein 0.0039 0.0332 0.0613
Schistosoma mansoni alpha glucosidase 0.0035 0.0275 0.0275
Echinococcus multilocularis phd:f box containing protein 0.0025 0.011 0.011
Loa Loa (eye worm) WD domain-containing protein 0.0024 0.0098 0.0455
Echinococcus multilocularis alkaline phosphatase, intestinal, gene 2 0.0159 0.2156 0.2156
Entamoeba histolytica acyl-CoA synthetase, putative 0.0024 0.0103 0.004
Loa Loa (eye worm) hypothetical protein 0.0043 0.0396 0.1833
Schistosoma mansoni hypothetical protein 0.0083 0.0994 0.0994
Onchocerca volvulus 0.0035 0.0273 0.2186
Echinococcus granulosus neuropeptide receptor A26 0.0453 0.6614 0.6614
Mycobacterium tuberculosis Probable lipase LipE 0.0035 0.0273 0.059
Trichomonas vaginalis phospholipase A-2-activating protein, putative 0.0035 0.0273 0.0439
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0275 0.047
Trichomonas vaginalis D-aminoacylase, putative 0.0035 0.0273 0.0438
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0151 0.2032 0.2032
Trypanosoma cruzi WD domain, G-beta repeat/PFU (PLAA family ubiquitin binding), putative 0.0035 0.0273 0.0395
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0275 0.0443
Echinococcus multilocularis lysine specific demethylase 6a 0.0025 0.011 0.011
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1189 0.1189
Echinococcus granulosus lysosomal alpha glucosidase 0.016 0.216 0.216
Plasmodium falciparum beta-ketoacyl-ACP synthase III 0.0311 0.4455 1
Leishmania major hypothetical protein, conserved 0.0035 0.0273 0.0412
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0275 0.0275
Entamoeba histolytica fatty acid elongase, putative 0.004 0.035 0.0658
Schistosoma mansoni phospholipase A-2-activating protein 0.0024 0.0098 0.0098
Schistosoma mansoni alpha-glucosidase 0.0138 0.1823 0.1823
Loa Loa (eye worm) hypothetical protein 0.0038 0.0308 0.1425
Echinococcus multilocularis Polycystic kidney disease protein 0.0019 0.003 0.003
Brugia malayi WD domain containing protein 0.0035 0.0273 0.1139
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0275 0.0443
Entamoeba histolytica hypothetical protein 0.0039 0.0332 0.0613
Schistosoma mansoni cpg binding protein 0.0028 0.0164 0.0164
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0418 0.0417
Mycobacterium ulcerans aldehyde dehydrogenase 0.006 0.064 0.1417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Loa Loa (eye worm) TAR-binding protein 0.0062 0.0679 0.3145
Schistosoma mansoni hypothetical protein 0.0039 0.0332 0.0332
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0171 0.0171
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Plasmodium falciparum phd finger protein, putative 0.0029 0.0171 0.036
Schistosoma mansoni jumonji/arid domain-containing protein 0.0096 0.1189 0.1189
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0275 0.0443
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0418 0.0417
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0287 0.4084 1
Brugia malayi jmjC domain containing protein 0.0151 0.2032 0.9398
Echinococcus multilocularis intestinal type alkaline phosphatase 0.0159 0.2156 0.2156
Loa Loa (eye worm) hypothetical protein 0.004 0.0343 0.1588
Schistosoma mansoni tar DNA-binding protein 0.0062 0.0679 0.0679
Schistosoma mansoni hypothetical protein 0.0035 0.0263 0.0263
Loa Loa (eye worm) hypothetical protein 0.0019 0.003 0.0141
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0275 0.0275
Loa Loa (eye worm) hypothetical protein 0.0035 0.0273 0.1262
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0171 0.0171
Schistosoma mansoni alkaline phosphatase 0.0159 0.2156 0.2156
Mycobacterium ulcerans hypothetical protein 0.0035 0.0273 0.059
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0273 0.0394
Toxoplasma gondii PUL domain-containing protein 0.0035 0.0273 0.3071
Schistosoma mansoni mixed-lineage leukemia protein mll 0.006 0.0643 0.0643
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0507 0.0963
Plasmodium falciparum LCCL domain-containing protein 0.0019 0.003 0.0045
Loa Loa (eye worm) hypothetical protein 0.0051 0.0507 0.2345
Echinococcus granulosus jumonji domain containing protein 0.004 0.0341 0.034

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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