Detailed information for compound 1001145

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 379.326 | Formula: C15H27NO6P2
  • H donors: 4 H acceptors: 6 LogP: 1.47 Rotable bonds: 11
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCCCCCc1cc[n+](cc1)CC(P(=O)(O)O)P(=O)(O)[O-]
  • InChi: 1S/C15H27NO6P2/c1-2-3-4-5-6-7-8-14-9-11-16(12-10-14)13-15(23(17,18)19)24(20,21)22/h9-12,15H,2-8,13H2,1H3,(H3-,17,18,19,20,21,22)
  • InChiKey: PACFVAFKZHUPEN-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens geranylgeranyl diphosphate synthase 1 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Trypanosoma congolense Hydroxyneurosporene synthase (CrtC)/Polyprenyl synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma mansoni geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania major polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania mexicana polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Echinococcus granulosus geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Brugia malayi geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Trypanosoma cruzi polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania infantum polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum ko:K00787 dimethylallyltranstransferase [EC2.5.1.1], putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania braziliensis polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Schistosoma japonicum Geranylgeranyl pyrophosphate synthetase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Leishmania donovani polyprenyl synthase, putative Get druggable targets OG5_129071 All targets in OG5_129071
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase Get druggable targets OG5_129071 All targets in OG5_129071
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Treponema pallidum octaprenyl-diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
Candida albicans geranylgeranyl diphosphate synthase Get druggable targets OG5_129071 All targets in OG5_129071
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative geranylgeranyl diphosphate synthase 1 300 aa 317 aa 21.4 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0307 0.1475
Loa Loa (eye worm) hypothetical protein 0.0054 0.0295 0.095
Brugia malayi beta-lactamase 0.0188 0.1429 0.46
Trypanosoma brucei phosphatidylinositol 3-related kinase, putative 0.0034 0.0125 0.0506
Toxoplasma gondii hypothetical protein 0.0027 0.0067 0.0346
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0069 0.0361
Echinococcus multilocularis prenyl (decaprenyl) diphosphate synthase 0.0031 0.0103 0.0168
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0078 0.0503 0.3198
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0022 0.0024 0.0038
Echinococcus granulosus Smad4 0.0026 0.0061 0.0099
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 0.3013
Onchocerca volvulus 0.0188 0.1429 0.6826
Leishmania major phosphatidylinositol 3-related kinase, putative 0.0034 0.0125 0.0758
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1429 1
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0125 0.0874
Brugia malayi ecdysteroid receptor 0.0022 0.0024 0.0076
Schistosoma mansoni smad1 5 8 and 0.0026 0.0061 0.0099
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0031 0.0103 0.0601
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 1
Schistosoma mansoni farnesyl pyrophosphate synthase 0.0031 0.0103 0.0168
Leishmania major polyprenyl synthase, putative 0.0127 0.0918 0.638
Trypanosoma brucei phosphatidylinositol kinase related protein, putative 0.0034 0.0124 0.0502
Plasmodium falciparum octaprenyl pyrophosphate synthase 0.0031 0.0103 0.0826
Onchocerca volvulus 0.0188 0.1429 0.6826
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.113 0.1834
Brugia malayi MH2 domain containing protein 0.0026 0.0061 0.0197
Echinococcus multilocularis smad 0.0026 0.0061 0.0099
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0024 0.0076
Brugia malayi intermediate filament protein 0.0031 0.0103 0.0331
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 0.3013
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0065 0.0388 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0226 0.1088
Echinococcus multilocularis FTZ F1 alpha 0.0022 0.0024 0.0038
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0022 0.0024 0.0076
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0034 0.0124 0.087
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0069 0.0015
Mycobacterium ulcerans lipase LipD 0.0188 0.1429 1
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0043 0.0204 0.0331
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0414 0.2341
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0068 0.0414 0.0671
Loa Loa (eye worm) phosphatidylinositol 3 0.0034 0.0125 0.0402
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0022 0.0024 0.0038
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0022 0.0024 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0162 0.0777
Brugia malayi Polyprenyl synthetase family protein 0.0031 0.0103 0.0332
Schistosoma mansoni smad 0.0026 0.0061 0.0099
Entamoeba histolytica hypothetical protein 0.0043 0.0204 0.5253
Loa Loa (eye worm) transcription factor SMAD2 0.0386 0.3106 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0349 0.2799 0.9012
Brugia malayi RNA recognition motif domain containing protein 0.0349 0.2799 0.9012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0307 0.1475
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0989
Mycobacterium ulcerans hypothetical protein 0.0188 0.1429 1
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0068 0.0414 0.2804
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0065 0.0388 0.2424
Echinococcus multilocularis lamin dm0 0.0031 0.0103 0.0167
Mycobacterium ulcerans esterase/lipase LipP 0.0188 0.1429 1
Brugia malayi RNA binding protein 0.0349 0.2799 0.9012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0307 0.1475
Toxoplasma gondii polyprenyl synthetase superfamily protein 0.0031 0.0103 0.0601
Trypanosoma brucei solanesyl-diphosphate synthase, putative 0.0031 0.0103 0.0348
Brugia malayi beta-lactamase family protein 0.0188 0.1429 0.46
Brugia malayi Nuclear hormone receptor-like 1 0.0022 0.0024 0.0076
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0188 0.1429 0.134
Trypanosoma brucei trypanothione reductase 0.0055 0.0302 0.1797
Brugia malayi Polyprenyl synthetase family protein 0.0031 0.0103 0.0332
Echinococcus granulosus phosphatidylinositol 3 and 4 kinase 0.0034 0.0125 0.0203
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0125 0.0896 0.6088
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0024 0.0076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0022 0.0024 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.06
Mycobacterium tuberculosis Probable dehydrogenase 0.0125 0.0896 0.0801
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.0486
Trichomonas vaginalis PIKK family atypical protein kinase 0.0046 0.0226 0.1088
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0272 0.2146 0.3482
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0162 0.0777
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Echinococcus multilocularis ecdysone induced protein 78C 0.0022 0.0024 0.0038
Loa Loa (eye worm) steroid hormone receptor 0.0022 0.0024 0.0076
Onchocerca volvulus 0.0033 0.0121 0.0474
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.113 0.3638
Echinococcus granulosus lamin dm0 0.0031 0.0103 0.0167
Schistosoma mansoni smad1 5 8 and 0.0026 0.0061 0.0099
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0065 0.0388 0.2717
Loa Loa (eye worm) polyprenyl synthetase 0.0031 0.0103 0.0332
Loa Loa (eye worm) hypothetical protein 0.0031 0.0098 0.0316
Plasmodium vivax glutathione reductase, putative 0.0055 0.0302 0.1725
Brugia malayi MH1 domain containing protein 0.0026 0.0061 0.0197
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0033 0.0121 0.0197
Schistosoma mansoni hypothetical protein 0.0196 0.15 0.2435
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0051 0.0274 0.0172
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0022 0.0024 0.0076
Echinococcus multilocularis peptidase Clp (S14 family) 0.0051 0.0274 0.0444
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0069 0.0102
Echinococcus multilocularis geranylgeranyl pyrophosphate synthase 0.0127 0.0918 0.149
Loa Loa (eye worm) hypothetical protein 0.0037 0.0151 0.0485
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0065 0.0388 0.063
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0043 0.0204 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0022 0.0024 0.0076
Echinococcus granulosus geranylgeranyl pyrophosphate synthase 0.0127 0.0918 0.149
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0078 0.0503 0.0816
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.113 0.1834
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0022 0.0024 0.0076
Plasmodium vivax octaprenyl pyrophosphate synthase, putative 0.0031 0.0103 0.0264
Echinococcus granulosus histone lysine methyltransferase setb 0.0033 0.0121 0.0197
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0078 0.0503 0.3198
Trypanosoma cruzi farnesyl pyrophosphate synthase, putative 0.0031 0.0103 0.0722
Mycobacterium tuberculosis Conserved protein 0.0188 0.1429 0.134
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 1
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0188 0.1429 0.46
Plasmodium vivax thioredoxin reductase, putative 0.0055 0.0302 0.1725
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Trypanosoma brucei phosphatidylinositol 3-kinase, putative 0.0034 0.0125 0.0506
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0022 0.0024 0.0038
Toxoplasma gondii FATC domain-containing protein 0.0034 0.0124 0.0751
Leishmania major hypothetical protein, conserved 0.0188 0.1429 1
Mycobacterium leprae conserved hypothetical protein 0.0188 0.1429 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.06
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0024 0.0038
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0022 0.0024 0.0076
Brugia malayi geranylgeranyl pyrophosphate synthetase 0.0127 0.0918 0.2956
Mycobacterium tuberculosis Probable esterase LipL 0.0188 0.1429 0.134
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2799 0.4543
Mycobacterium leprae Probable lipase LipE 0.0188 0.1429 1
Echinococcus multilocularis decaprenyl diphosphate synthase subunit 1 0.0031 0.0103 0.0168
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.0103 0.0331
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0223
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0988
Brugia malayi Thioredoxin reductase 0.0055 0.0302 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0388 0.1865
Loa Loa (eye worm) Smad1 0.0026 0.0061 0.0197
Mycobacterium tuberculosis Probable oxidoreductase 0.0139 0.1014 0.0921
Loa Loa (eye worm) MH2 domain-containing protein 0.0026 0.0061 0.0197
Echinococcus granulosus tar DNA binding protein 0.0349 0.2799 0.4543
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0065 0.0388 0.2424
Leishmania major solanesyl-diphosphate synthase, putative 0.0031 0.0103 0.0605
Echinococcus granulosus peptidase Clp S14 family 0.0051 0.0274 0.0444
Schistosoma mansoni trans-prenyltransferase 0.0031 0.0103 0.0168
Echinococcus granulosus lamin 0.0031 0.0103 0.0167
Toxoplasma gondii target of rapamycin (TOR), putative 0.0053 0.0287 0.1902
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Schistosoma mansoni hypothetical protein 0.0272 0.2146 0.3482
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0022 0.0024 0.0038
Trypanosoma cruzi phosphatidylinositol 3-related kinase, putative 0.0034 0.0125 0.0874
Echinococcus multilocularis Smad4 0.0026 0.0061 0.0099
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Trypanosoma brucei farnesyl pyrophosphate synthase 0.0031 0.0103 0.0348
Brugia malayi hypothetical protein 0.0043 0.0204 0.0657
Brugia malayi steroid hormone receptor 0.0022 0.0024 0.0076
Loa Loa (eye worm) intermediate filament protein 0.0031 0.0103 0.0331
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0022 0.0024 0.0076
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0065 0.0388 1
Plasmodium vivax SET domain protein, putative 0.0033 0.0121 0.0396
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0125 0.0402
Echinococcus granulosus TGF beta signal transducer SmadC 0.0026 0.0061 0.0099
Entamoeba histolytica hypothetical protein 0.0043 0.0204 0.5253
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2799 0.4543
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0414 0.0671
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0125 0.0896 0.0801
Schistosoma mansoni thyroid hormone receptor 0.0294 0.2331 0.3783
Schistosoma mansoni lamin 0.0031 0.0103 0.0167
Schistosoma mansoni peptidase Clp (S14 family) 0.0078 0.0503 0.0816
Entamoeba histolytica geranylgeranyl pyrophosphate synthetase, putative 0.0031 0.0103 0.2659
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0031 0.0103 0.0496
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0022 0.0024 0.0038
Mycobacterium tuberculosis Conserved protein 0.0188 0.1429 0.134
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.0048
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1429 0.2319
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0022 0.0024 0.0076
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0024 0.0076
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0022 0.0024 0.0076
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.113 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0989
Schistosoma mansoni microtubule-associated protein tau 0.0746 0.6162 1
Plasmodium vivax hypothetical protein, conserved 0.0188 0.1429 1
Brugia malayi latrophilin 2 splice variant baaae 0.0037 0.0151 0.0485
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0388 0.1865
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0989
Loa Loa (eye worm) beta-lactamase 0.0188 0.1429 0.46
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0022 0.0024 0.0038
Schistosoma mansoni coup transcription factor 0.0022 0.0024 0.0038
Mycobacterium tuberculosis Conserved protein 0.0188 0.1429 0.134
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0022 0.0024 0.0076
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1429 0.6862
Echinococcus granulosus intermediate filament protein 0.0031 0.0103 0.0167
Brugia malayi photoreceptor-specific nuclear receptor 0.0022 0.0024 0.0076
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2799 0.4543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.06
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0051 0.0274 0.0172
Echinococcus multilocularis thyroid hormone receptor alpha 0.0294 0.2331 0.3783
Schistosoma mansoni retinoic acid receptor RXR 0.0022 0.0024 0.0038
Schistosoma mansoni RAR-like nuclear receptor 0.0022 0.0024 0.0038
Entamoeba histolytica geranylgeranyl pyrophosphate synthase, putative 0.0031 0.0103 0.2659
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0414 0.2341
Echinococcus multilocularis geminin 0.0196 0.15 0.2435
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0503 0.3433
Mycobacterium tuberculosis Probable reductase 0.0125 0.0896 0.0801
Plasmodium vivax geranylgeranyl pyrophosphate synthase 0.0031 0.0103 0.0264
Schistosoma mansoni Smad4 0.0026 0.0061 0.0099
Schistosoma mansoni ataxia telangiectasia mutated (atm) 0.0034 0.0124 0.0202
Entamoeba histolytica hypothetical protein 0.0043 0.0204 0.5253
Schistosoma mansoni lamin 0.0031 0.0103 0.0167
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0034 0.0124 0.04
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0065 0.0388 0.2625
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0068 0.0414 0.0314
Trypanosoma cruzi farnesyl pyrophosphate synthase 0.0031 0.0103 0.0722
Echinococcus granulosus prenyl decaprenyl diphosphate synthase 0.0031 0.0103 0.0168
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0125 0.0896 0.0801
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Echinococcus granulosus serine protein kinase ATM 0.0034 0.0124 0.0202
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0027 0.0069 0.0485
Loa Loa (eye worm) TAR-binding protein 0.0349 0.2799 0.9012
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0024 0.0038
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.06
Echinococcus multilocularis mothers against decapentaplegic 5 0.0026 0.0061 0.0099
Echinococcus multilocularis microtubule associated protein 2 0.0746 0.6162 1
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0988
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0078 0.0503 0.0816
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0022 0.0024 0.0076
Onchocerca volvulus 0.0265 0.2082 1
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0033 0.0121 0.0728
Brugia malayi Calcitonin receptor-like protein seb-1 0.0054 0.0295 0.095
Echinococcus multilocularis phosphatidylinositol 3 and 4 kinase 0.0034 0.0125 0.0203
Trypanosoma brucei FAT domain/Rapamycin binding domain/Phosphatidylinositol 3- and 4-kinase, putative 0.0031 0.01 0.0322
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.0103 0.0331
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0188 0.1429 0.46
Trypanosoma cruzi target of rapamycin kinase 3 0.0055 0.0308 0.2152
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 1
Toxoplasma gondii thioredoxin reductase 0.0055 0.0302 0.2011
Echinococcus granulosus decaprenyl diphosphate synthase subunit 1 0.0031 0.0103 0.0168
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0197
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0125 0.0896 0.0801
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0022 0.0024 0.0076
Mycobacterium tuberculosis Probable lipase LipD 0.0188 0.1429 0.134
Echinococcus granulosus farnesyl pyrophosphate synthase 0.0031 0.0103 0.0168
Trypanosoma brucei hypothetical protein, conserved 0.0188 0.1429 1
Brugia malayi nuclear hormone receptor 0.0022 0.0024 0.0076
Toxoplasma gondii aldehyde dehydrogenase 0.0068 0.0414 0.2802
Schistosoma mansoni glutathione synthetase 0.0031 0.0103 0.0168
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0026 0.0061 0.0099
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1429 0.6862
Echinococcus granulosus smad 0.0026 0.0061 0.0099
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0125 0.0896 0.0801
Schistosoma mansoni hypothetical protein 0.0037 0.0151 0.0245
Trichomonas vaginalis conserved hypothetical protein 0.0021 0.0018 0.0089
Entamoeba histolytica hypothetical protein 0.0034 0.0124 0.3203
Echinococcus multilocularis beta LACTamase domain containing family member 0.0188 0.1429 0.2319
Loa Loa (eye worm) hypothetical protein 0.0078 0.0503 0.1618
Echinococcus granulosus geminin 0.0196 0.15 0.2435
Schistosoma mansoni aldehyde dehydrogenase 0.0068 0.0414 0.0671
Brugia malayi Probable ClpP-like protease 0.0078 0.0503 0.1618
Brugia malayi Smad1 0.0026 0.0061 0.0197
Entamoeba histolytica bifunctional short chain isoprenyl diphosphate synthase, putative 0.0031 0.0103 0.2659
Brugia malayi Pre-SET motif family protein 0.0233 0.181 0.5827
Echinococcus multilocularis musashi 0.0031 0.0103 0.0167
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1429 0.6862
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0188 0.1429 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.113 0.3638
Plasmodium falciparum geranylgeranyl pyrophosphate synthase, putative 0.0031 0.0103 0.0826
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0068 0.0414 0.0671
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0054 0.0295 0.095
Brugia malayi Steroid receptor seven-up type 2 0.0022 0.0024 0.0076
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0031 0.0103 0.0722
Plasmodium falciparum glutathione reductase 0.0055 0.0302 0.5394
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0054 0.0295 0.095
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Brugia malayi MH1 domain containing protein 0.0026 0.0061 0.0197
Echinococcus granulosus microtubule associated protein 2 0.0746 0.6162 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0055 0.0302 0.049
Mycobacterium ulcerans aldehyde dehydrogenase 0.0068 0.0414 0.2341
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0055 0.0308 0.1836
Mycobacterium tuberculosis Probable hydrolase 0.0188 0.1429 0.134
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0022 0.0024 0.0038
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0055 0.0308 0.2053
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0139 0.1014 0.6955
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0022 0.0024 0.0038
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0233 0.181 0.5827
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2799 0.4543
Brugia malayi glutathione reductase 0.0055 0.0302 0.0973
Trichomonas vaginalis PIKK family atypical protein kinase 0.005 0.0263 0.1265
Mycobacterium tuberculosis Probable lipase LipE 0.0188 0.1429 0.134
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0022 0.0024 0.0076
Leishmania major phosphatidylinositol 3-kinase, putative 0.0034 0.0125 0.0758
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0272 0.2146 0.3482
Echinococcus multilocularis thioredoxin glutathione reductase 0.0055 0.0302 0.049
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Entamoeba histolytica hypothetical protein 0.0043 0.0204 0.5253
Echinococcus multilocularis serine protein kinase ATM 0.0034 0.0124 0.0202
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0188 0.1429 0.134
Brugia malayi MH2 domain containing protein 0.0386 0.3106 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0065 0.0388 0.1865
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0051 0.0274 0.1517
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Trichomonas vaginalis geranylgeranyl diphosphate synthase, putative 0.0031 0.0103 0.0496
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0022 0.0024 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0069 0.0223
Echinococcus multilocularis tar DNA binding protein 0.0349 0.2799 0.4543
Trypanosoma cruzi solanesyl-diphosphate synthase 0.0031 0.0103 0.0722
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0069 0.0048
Trypanosoma cruzi polyprenyl synthase, putative 0.0127 0.0918 0.6425
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0139 0.1014 0.0921
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0055 0.0302 0.0201
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0065 0.0388 0.063
Onchocerca volvulus 0.0031 0.0103 0.0385
Onchocerca volvulus 0.0188 0.1429 0.6826
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0022 0.0024 0.0038
Loa Loa (eye worm) phosphatidylinositol 3 0.0065 0.0388 0.125
Leishmania major trypanothione reductase 0.0055 0.0302 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0307 0.1475
Brugia malayi hypothetical protein 0.0027 0.0069 0.0223
Trichomonas vaginalis penicillin-binding protein, putative 0.0188 0.1429 0.6862
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0033 0.0121 0.0197
Plasmodium falciparum thioredoxin reductase 0.0055 0.0302 0.5394
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0022 0.0024 0.0038
Leishmania major farnesyl pyrophosphate synthase 0.0031 0.0103 0.0605
Brugia malayi beta-lactamase family protein 0.0188 0.1429 0.46
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0124 0.0597
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0022 0.0024 0.0038
Treponema pallidum octaprenyl-diphosphate synthase 0.0127 0.0918 1
Trichomonas vaginalis geranylgeranyl pyrophosphate synthase, putative 0.0031 0.0103 0.0496
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0022 0.0024 0.0076
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0033 0.0121 0.0197
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0065 0.0388 0.063
Trichomonas vaginalis D-aminoacylase, putative 0.0188 0.1429 0.6862
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0201 0.0964
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0033 0.0121 0.0197
Loa Loa (eye worm) MH1 domain-containing protein 0.0026 0.0061 0.0197
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.113 0.1834
Trypanosoma cruzi polyprenyl synthase, putative 0.0127 0.0918 0.6425
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0065 0.0388 0.2717
Loa Loa (eye worm) hypothetical protein 0.0021 0.0018 0.0059
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Mycobacterium ulcerans beta-lactamase 0.0188 0.1429 1
Trypanosoma cruzi hypothetical protein, conserved 0.0188 0.1429 1
Loa Loa (eye worm) geranylgeranyl pyrophosphate synthetase 0.0127 0.0918 0.2956
Loa Loa (eye worm) hypothetical protein 0.0031 0.0103 0.0331
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0111 0.018
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.113 0.1834
Trichomonas vaginalis PIKK family atypical protein kinase 0.0034 0.0125 0.06
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.113 0.1834
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0022 0.0024 0.0076
Mycobacterium leprae PROBABLE POLYPRENYL-DIPHOSPHATE SYNTHASE GRCC1 (POLYPRENYL PYROPHOSPHATE SYNTHETASE) 0.0031 0.0103 0.0264
Trichomonas vaginalis PIKK family atypical protein kinase 0.0041 0.0182 0.0875
Loa Loa (eye worm) MH2 domain-containing protein 0.0386 0.3106 1
Schistosoma mansoni steroid hormone receptor ad4bp 0.0022 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Leishmania major hypothetical protein, conserved 0.0027 0.0069 0.0365
Schistosoma mansoni nuclear hormone receptor 0.0022 0.0024 0.0038
Trypanosoma cruzi solanesyl-diphosphate synthase, putative 0.0031 0.0103 0.0722
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0078 0.0503 0.5118
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0022 0.0024 0.0038
Schistosoma mansoni hypothetical protein 0.0196 0.15 0.2435
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0069 0.0486
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0022 0.0024 0.0076
Brugia malayi Pre-SET motif family protein 0.0033 0.0121 0.039
Trichomonas vaginalis set domain proteins, putative 0.0265 0.2082 1
Echinococcus multilocularis farnesyl pyrophosphate synthase 0.0031 0.0103 0.0168
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0022 0.0024 0.0038
Trypanosoma cruzi trypanothione reductase, putative 0.0055 0.0302 0.2114
Schistosoma mansoni smad1 5 8 and 0.0026 0.0061 0.0099
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0989
Onchocerca volvulus 0.0031 0.0103 0.0385
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0026 0.0061 0.0099
Echinococcus granulosus beta LACTamase domain containing family member 0.0188 0.1429 0.2319
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0078 0.0503 0.3433
Brugia malayi nuclear receptor NHR-88 0.0022 0.0024 0.0076
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0162 0.0777
Trichomonas vaginalis esterase, putative 0.0188 0.1429 0.6862
Loa Loa (eye worm) glutathione reductase 0.0055 0.0302 0.0973
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0022 0.0024 0.0076
Brugia malayi MH2 domain containing protein 0.0026 0.0061 0.0197
Loa Loa (eye worm) hypothetical protein 0.0033 0.0121 0.039
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.113 0.1834
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0188 0.1429 0.134
Schistosoma mansoni tar DNA-binding protein 0.0349 0.2799 0.4543
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Schistosoma mansoni hypothetical protein 0.0043 0.0204 0.0331
Trypanosoma cruzi phosphatidylinositol kinase related protein, putative 0.0021 0.0018 0.0125
Toxoplasma gondii ABC1 family protein 0.0188 0.1429 1
Echinococcus granulosus FTZ F1 alpha 0.0022 0.0024 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Schistosoma mansoni thyroid hormone receptor 0.0294 0.2331 0.3783
Loa Loa (eye worm) RNA binding protein 0.0349 0.2799 0.9012
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0188 0.1429 0.2319
Echinococcus multilocularis lamin 0.0031 0.0103 0.0167
Trichomonas vaginalis PIKK family atypical protein kinase 0.0055 0.0307 0.1475
Schistosoma mansoni intermediate filament proteins 0.0031 0.0103 0.0167
Loa Loa (eye worm) hypothetical protein 0.0188 0.1429 0.46
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0065 0.0388 0.125
Trichomonas vaginalis PIKK family atypical protein kinase 0.0043 0.0206 0.0988
Echinococcus granulosus mothers against decapentaplegic 5 0.0026 0.0061 0.0099
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0065 0.0388 0.2625
Schistosoma mansoni geranylgeranyl pyrophosphate synthase 0.0127 0.0918 0.149
Brugia malayi TAR-binding protein 0.0349 0.2799 0.9012
Trichomonas vaginalis PIKK family atypical protein kinase 0.0053 0.0287 0.1377
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0022 0.0024 0.0038
Schistosoma mansoni phosphatidylinositol 3-and 4-kinase 0.0034 0.0125 0.0203
Loa Loa (eye worm) hypothetical protein 0.0022 0.0024 0.0076
Giardia lamblia GTOR 0.0065 0.0388 1
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0139 0.1014 0.0921
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0022 0.0024 0.0038
Loa Loa (eye worm) polyprenyl synthetase 0.0031 0.0103 0.0332
Echinococcus granulosus ecdysone induced protein 78C 0.0022 0.0024 0.0038
Loa Loa (eye worm) thioredoxin reductase 0.0055 0.0302 0.0973
Schistosoma mansoni transcription factor LCR-F1 0.0043 0.0204 0.0331

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 6.2 Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762
IC50 (binding) = 0.66 uM Inhibition of human recombinant geranylgeranyl diphosphate synthase ChEMBL. 18800762

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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