Detailed information for compound 1001234

Basic information

Technical information
  • TDR Targets ID: 1001234
  • Name: N-(4-bromophenyl)-2-(3-methyl-4-oxophthalazin -1-yl)acetamide
  • MW: 372.216 | Formula: C17H14BrN3O2
  • H donors: 1 H acceptors: 2 LogP: 2.9 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C(Cc1nn(C)c(=O)c2c1cccc2)Nc1ccc(cc1)Br
  • InChi: 1S/C17H14BrN3O2/c1-21-17(23)14-5-3-2-4-13(14)15(20-21)10-16(22)19-12-8-6-11(18)7-9-12/h2-9H,10H2,1H3,(H,19,22)
  • InChiKey: BGFHNOQFTJLVRK-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • N-(4-bromophenyl)-2-(3-methyl-4-oxo-phthalazin-1-yl)acetamide
  • N-(4-bromophenyl)-2-(3-methyl-4-oxo-1-phthalazinyl)acetamide
  • N-(4-bromophenyl)-2-(4-keto-3-methyl-phthalazin-1-yl)acetamide
  • N-(4-bromophenyl)-2-(3-methyl-4-oxo-phthalazin-1-yl)ethanamide
  • STK138104
  • BAS 04948637
  • N-(4-Bromo-phenyl)-2-(3-methyl-4-oxo-3,4-dihydro-phthalazin-1-yl)-acetamide
  • ZINC00787346

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium parvum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma japonicum ko:K00088 IMP dehydrogenase [EC1.1.1.205], putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Neospora caninum hypothetical protein Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Cryptosporidium hominis inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Loa Loa (eye worm) IMP dehydrogenase 1 Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans guanosine nucleotide biosynthesis Get druggable targets OG5_126887 All targets in OG5_126887
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 Get druggable targets OG5_126887 All targets in OG5_126887
Toxoplasma gondii IMP dehydrogenas Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Babesia bovis inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania infantum inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Schistosoma mansoni inosine-5-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania donovani inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei gambiense inosine-5-monophosphate dehydrogenase,IMP dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium berghei inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania mexicana guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma brucei GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium knowlesi inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania braziliensis guanosine monophosphate reductase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Trypanosoma congolense GMP reductase Get druggable targets OG5_126887 All targets in OG5_126887
Plasmodium yoelii inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
Theileria parva Inosine-5'-monophosphate dehydrogenase, putative Get druggable targets OG5_126887 All targets in OG5_126887
Leishmania major guanosine monophosphate reductase Get druggable targets OG5_126887 All targets in OG5_126887
Candida albicans N terminus of Inosine-5'-monophosphate dehydrogenase Get druggable targets OG5_126887 All targets in OG5_126887
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0059 0.0329 0.0498
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0172 0.1562 0.204
Echinococcus granulosus intermediate filament protein 0.003 0.0006 0.0008
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0081 0.0569 0.0736
Loa Loa (eye worm) intermediate filament protein 0.003 0.0006 0.0016
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0091 0.0675 0.0875
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0172 0.1562 0.3943
Giardia lamblia Kinase, PLK 0.0092 0.0684 0.0367
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0172 0.1562 0.4206
Schistosoma mansoni hypothetical protein 0.008 0.0554 0.0717
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.1562 0.204
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0172 0.1562 0.204
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.005 0.0226 0.0275
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0763 0.099
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Onchocerca volvulus 0.003 0.0014 0.0023
Echinococcus granulosus inosine 5' monophosphate dehydrogenase 2 0.0134 0.1145 0.1497
Trypanosoma cruzi transcription factor btf3, putative 0.0229 0.2188 1
Toxoplasma gondii NAC domain-containing protein 0.0229 0.2188 1
Echinococcus granulosus lamin 0.003 0.0006 0.0008
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0081 0.0569 0.1532
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0172 0.1562 0.2034
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.1562 0.3943
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.003 0.0006 0.0016
Trichomonas vaginalis set domain proteins, putative 0.024 0.2309 0.2232
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Loa Loa (eye worm) nuclear hormone receptor 0.0081 0.0569 0.1532
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0081 0.0569 0.0736
Loa Loa (eye worm) beta-lactamase 0.0038 0.0099 0.0266
Loa Loa (eye worm) hypothetical protein 0.0048 0.021 0.0566
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0675 0.1701
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0329 0.1466
Brugia malayi PHD-finger family protein 0.0059 0.0329 0.0825
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0092 0.0684 0.3096
Brugia malayi Pre-SET motif family protein 0.0211 0.199 0.5026
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0243 0.2342 0.4851
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0172 0.1562 0.204
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0172 0.1562 0.2034
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0081 0.0569 0.0628
Echinococcus granulosus histone lysine methyltransferase setb 0.0119 0.0985 0.1287
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0172 0.1562 0.3943
Brugia malayi nuclear receptor NHR-88 0.0081 0.0569 0.1432
Schistosoma mansoni hypothetical protein 0.0033 0.0043 0.0049
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.003 0.0014 0.001
Plasmodium vivax inosine-5'-monophosphate dehydrogenase, putative 0.0134 0.1145 0.5214
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Loa Loa (eye worm) DR-78 0.0081 0.0569 0.1532
Echinococcus multilocularis transient receptor potential ion channel A 0.0103 0.0815 0.0899
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.5
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0151 0.1338 0.1748
Entamoeba histolytica hypothetical protein 0.0151 0.1338 0.0703
Echinococcus multilocularis peregrin 0.0071 0.0464 0.0512
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Brugia malayi hypothetical protein 0.0081 0.0569 0.1432
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0099 0.0763 0.2056
Brugia malayi beta-lactamase family protein 0.0038 0.0099 0.0243
Schistosoma mansoni peptidase Clp (S14 family) 0.0076 0.0512 0.0661
Schistosoma mansoni serine/threonine protein kinase 0.0092 0.0684 0.0886
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0099 0.0266
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0582 0.076
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Schistosoma mansoni hypothetical protein 0.0151 0.1338 0.1742
Brugia malayi beta-lactamase 0.0038 0.0099 0.0243
Loa Loa (eye worm) hypothetical protein 0.0368 0.3713 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0684 0.3096
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0457 0.0505
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0048 0.021 0.0525
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0668
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.0569 0.0743
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0081 0.0569 0.1432
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Trypanosoma brucei ISWI complex protein 0.008 0.0554 0.2502
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0193 0.1799 0.235
Loa Loa (eye worm) RNA binding protein 0.0279 0.2736 0.737
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0172 0.1562 0.204
Loa Loa (eye worm) hypothetical protein 0.0033 0.0043 0.0116
Schistosoma mansoni transient receptor potential channel 4 0.0107 0.0854 0.1108
Echinococcus granulosus microtubule associated protein 2 0.0729 0.7654 1
Schistosoma mansoni retinoic acid receptor RXR 0.0172 0.1562 0.2034
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.1562 0.3943
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0081 0.0569 0.0743
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0461 0.4723 1
Schistosoma mansoni zinc finger protein 0.0102 0.0798 0.1036
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0172 0.1562 0.2034
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0943 1 1
Onchocerca volvulus Serine\/threonine kinase homolog 0.0092 0.0684 0.2082
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.2188 0.211
Echinococcus multilocularis lamin 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.003 0.0009 0.0024
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0059 0.0329 0.0825
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0411
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0329 0.0429
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0457 0.0597
Brugia malayi nuclear hormone receptor 0.0081 0.0569 0.1432
Mycobacterium leprae PROBABLE INOSINE-5'-MONOPHOSPHATE DEHYDROGENASE GUAB1(IMP DEHYDROGENASE) (IMPDH) (IMPD) 0.0059 0.0329 0.0498
Echinococcus multilocularis geminin 0.0724 0.7605 0.8396
Brugia malayi hypothetical protein 0.0091 0.0675 0.1701
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.1562 0.1724
Echinococcus granulosus zinc finger protein 0.0102 0.0798 0.1043
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0119 0.0985 0.1088
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.005 0.0226 0.0275
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0211 0.199 0.536
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.2188 0.211
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0099 0.0411
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB2 (IMP dehydrogenase) (IMPDH) (IMPD) 0.0134 0.1145 0.2264
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0279 0.2736 0.737
Brugia malayi Muscleblind-like protein 0.0151 0.1339 0.3379
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.0569 0.1729
Trypanosoma brucei polo-like protein kinase 0.0092 0.0684 0.3096
Schistosoma mansoni tar DNA-binding protein 0.0279 0.2736 0.357
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0465 0.0513
Schistosoma mansoni hypothetical protein 0.0059 0.0329 0.0422
Brugia malayi serine/threonine-protein kinase plk-2 0.0092 0.0684 0.1723
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0172 0.1562 0.3943
Schistosoma mansoni kinase 0.0047 0.0191 0.0242
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0172 0.1562 0.3943
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Brugia malayi Probable ClpP-like protease 0.0076 0.0512 0.1287
Brugia malayi steroid hormone receptor 0.0172 0.1562 0.3943
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Trypanosoma brucei transcription factor BTF3, putative 0.0229 0.2188 1
Schistosoma mansoni lipoxygenase 0.0061 0.0345 0.0443
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0076 0.0512 0.0892
Brugia malayi Nuclear hormone receptor E75 0.0081 0.0569 0.1432
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0081 0.0569 0.1729
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0193 0.1799 0.1986
Brugia malayi Nuclear hormone receptor E75 0.0081 0.0569 0.1432
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.2305
Loa Loa (eye worm) ICD-1 protein 0.0229 0.2188 0.5894
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0763 0.099
Brugia malayi Steroid receptor seven-up type 2 0.0172 0.1562 0.3943
Echinococcus granulosus peptidase Clp S14 family 0.005 0.0226 0.0295
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.003 0.0014 0.0015
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0091 0.0675 0.1818
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0172 0.1562 0.3943
Echinococcus granulosus muscleblind protein 0.0151 0.1339 0.1749
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0172 0.1562 0.1724
Loa Loa (eye worm) PHD-finger family protein 0.0107 0.0858 0.2312
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0092 0.0684 0.0755
Echinococcus multilocularis peptidase Clp (S14 family) 0.005 0.0226 0.0249
Onchocerca volvulus Alhambra homolog 0.0059 0.0329 0.0991
Brugia malayi hypothetical protein 0.0081 0.0569 0.1432
Brugia malayi nuclear receptor NHR-88 0.0172 0.1562 0.3943
Echinococcus multilocularis thyroid hormone receptor alpha 0.0172 0.1562 0.1724
Trichomonas vaginalis conserved hypothetical protein 0.0229 0.2188 0.211
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Brugia malayi Intermediate filament tail domain containing protein 0.003 0.0006 0.0009
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0178 0.008
Schistosoma mansoni transient receptor potential channel 0.0071 0.0457 0.059
Brugia malayi nuclear hormone receptor family member nhr-6 0.0081 0.0569 0.1432
Echinococcus multilocularis zinc finger protein 0.0102 0.0798 0.0881
Schistosoma mansoni transcription factor LCR-F1 0.0151 0.1338 0.1742
Schistosoma mansoni tar DNA-binding protein 0.0279 0.2736 0.357
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0857 0.9058 1
Echinococcus multilocularis transient receptor potential gamma protein 0.0107 0.0854 0.0942
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Schistosoma mansoni hypothetical protein 0.0724 0.7605 0.9935
Brugia malayi Bromodomain containing protein 0.0199 0.1865 0.4711
Brugia malayi Nuclear hormone receptor-like 1 0.0091 0.0675 0.1701
Echinococcus granulosus thyroid hormone receptor alpha 0.0081 0.0569 0.0743
Entamoeba histolytica hypothetical protein 0.0151 0.1338 0.0703
Brugia malayi intermediate filament protein 0.003 0.0006 0.0009
Brugia malayi inosine-5'-monophosphate dehydrogenase 0.0059 0.0329 0.0825
Trypanosoma cruzi transcription factor btf3, putative 0.0229 0.2188 1
Onchocerca volvulus Protein ultraspiracle homolog 0.0172 0.1562 0.478
Leishmania major guanosine monophosphate reductase 0.0134 0.1145 0.5214
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0573 0.0742
Echinococcus granulosus geminin 0.0724 0.7605 0.9935
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Schistosoma mansoni tar DNA-binding protein 0.0279 0.2736 0.357
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0099 0.0243
Echinococcus granulosus transcription factor btf3 0.0229 0.2188 0.2859
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0099 0.0763 0.099
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0091 0.0675 0.0746
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0061 0.0345 0.0381
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0172 0.1562 0.1724
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0099 0.0121
Echinococcus granulosus nuclear receptor nhr 48 0.0081 0.0569 0.0743
Echinococcus multilocularis short transient receptor potential channel 6 0.0071 0.0457 0.0505
Loa Loa (eye worm) hypothetical protein 0.0151 0.1339 0.3605
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0061 0.0345 0.0451
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0565
Schistosoma mansoni steroid hormone receptor ad4bp 0.0172 0.1562 0.2034
Brugia malayi nuclear receptor RXR 0.0091 0.0675 0.1701
Echinococcus multilocularis lamin dm0 0.003 0.0006 0.0007
Loa Loa (eye worm) hypothetical protein 0.0107 0.0854 0.2299
Schistosoma mansoni bromodomain containing protein 0.033 0.3289 0.4292
Brugia malayi RNA recognition motif domain containing protein 0.0279 0.2736 0.6914
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0985 0.128
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0117 0.0967 0.1257
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0329 0.0885
Schistosoma mansoni nuclear receptor 0.0081 0.0569 0.0736
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0569 0.0628
Toxoplasma gondii IMP dehydrogenas 0.0134 0.1145 0.5214
Schistosoma mansoni transient receptor potential channel 0.0071 0.0457 0.059
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0089 0.0654 0.0722
Trypanosoma brucei inosine-5'-monophosphate dehydrogenase 0.0134 0.1145 0.5214
Brugia malayi beta-NAC-like protein 0.0229 0.2188 0.5528
Schistosoma mansoni zinc finger protein 0.008 0.0554 0.0717
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0582 0.0642
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0048 0.021 0.0566
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0134 0.1145 0.5214
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0569 0.0736
Schistosoma mansoni thyroid hormone receptor 0.0172 0.1562 0.2034
Brugia malayi Calcitonin receptor-like protein seb-1 0.0048 0.021 0.0525
Brugia malayi ecdysteroid receptor 0.0172 0.1562 0.3943
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB2 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0134 0.1145 0.2264
Schistosoma mansoni methyl-cpg binding protein mbd 0.0089 0.0654 0.0848
Schistosoma mansoni transient receptor potential channel 0.0107 0.0854 0.1108
Echinococcus multilocularis musashi 0.003 0.0006 0.0007
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0172 0.1562 0.4206
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0172 0.1562 0.204
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0512 0.2305
Echinococcus multilocularis muscleblind protein 0.0151 0.1339 0.1478
Onchocerca volvulus 0.0038 0.0099 0.0285
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Trypanosoma cruzi polo-like protein kinase, putative 0.0092 0.0684 0.3096
Echinococcus multilocularis tar DNA binding protein 0.0279 0.2736 0.3021
Brugia malayi ecdysone receptor 0.0081 0.0569 0.1432
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0172 0.1562 0.1724
Loa Loa (eye worm) hypothetical protein 0.0059 0.0329 0.0885
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0172 0.1562 0.3943
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0091 0.0675 0.0882
Schistosoma mansoni tar DNA-binding protein 0.0279 0.2736 0.357
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.005 0.0226 0.0275
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0172 0.1562 0.4206
Echinococcus granulosus Nuclear hormone receptor HR96 0.0081 0.0569 0.0743
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0092 0.0684 0.0893
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0763 0.0997
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Brugia malayi latrophilin 2 splice variant baaae 0.0033 0.0043 0.0103
Loa Loa (eye worm) hypothetical protein 0.0212 0.2004 0.5397
Brugia malayi GMP reductase 0.0059 0.0329 0.0825
Loa Loa (eye worm) TAR-binding protein 0.0279 0.2736 0.737
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.0569 0.0628
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0172 0.1562 0.2034
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0172 0.1562 0.4206
Schistosoma mansoni zinc finger protein 0.0081 0.0569 0.0736
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0573 0.1544
Brugia malayi F/Y-rich N-terminus family protein 0.003 0.0015 0.0031
Echinococcus multilocularis transcription factor btf3 0.0229 0.2188 0.2416
Trypanosoma cruzi ISWI complex protein 0.008 0.0554 0.2502
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0099 0.0129
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0311 0.3085 0.3406
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.1562 0.3943
Brugia malayi Transient-receptor-potential like protein 0.004 0.0118 0.0292
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0892
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0329 0.1466
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0099 0.0763 0.1924
Onchocerca volvulus 0.024 0.2309 0.7076
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0172 0.1562 0.1724
Brugia malayi Bromodomain containing protein 0.0071 0.0464 0.1166
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0329 0.1466
Leishmania major basic transcription factor 3a, putative 0.0229 0.2188 1
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Loa Loa (eye worm) hypothetical protein 0.0067 0.0418 0.1126
Onchocerca volvulus 0.0081 0.0569 0.1729
Onchocerca volvulus 0.0327 0.3261 1
Leishmania major inosine-5-monophosphate dehydrogenase 0.0134 0.1145 0.5214
Mycobacterium leprae Probable inosine-5'-monophosphate dehydrogenase GuaB3 (IMP dehydrogenase 2) (inosinic acid dehydrogenase) (inosinate dehydrogena 0.0075 0.0499 0.0866
Giardia lamblia Fructose-bisphosphate aldolase 0.0943 1 1
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0187 0.173 0.191
Trypanosoma brucei GMP reductase 0.0134 0.1145 0.5214
Loa Loa (eye worm) hypothetical protein 0.0036 0.0079 0.0212
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0763 0.0843
Plasmodium falciparum basic transcription factor 3b, putative 0.0229 0.2188 1
Loa Loa (eye worm) hypothetical protein 0.004 0.0118 0.0318
Entamoeba histolytica hypothetical protein 0.0151 0.1338 0.0703
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0099 0.0411
Loa Loa (eye worm) hypothetical protein 0.0091 0.0675 0.1818
Loa Loa (eye worm) hypothetical protein 0.0076 0.0512 0.1377
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0172 0.1562 0.478
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0573 0.0742
Wolbachia endosymbiont of Brugia malayi IMP dehydrogenase 0.0134 0.1145 1
Entamoeba histolytica hypothetical protein 0.0151 0.1338 0.0703
Entamoeba histolytica hypothetical protein 0.0229 0.2188 0.1615
Loa Loa (eye worm) hypothetical protein 0.0101 0.079 0.2128
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0076 0.0512 0.2305
Echinococcus multilocularis TRP (transient receptor potential) channel 0.004 0.0118 0.013
Treponema pallidum fructose-bisphosphate aldolase 0.0943 1 1
Brugia malayi Pre-SET motif family protein 0.003 0.0014 0.0028
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0461 0.4723 1
Plasmodium vivax basic transcription factor 3b, putative 0.0229 0.2188 1
Echinococcus multilocularis nuclear receptor nhr 48 0.0081 0.0569 0.0628
Loa Loa (eye worm) hypothetical protein 0.003 0.0006 0.0016
Schistosoma mansoni nuclear receptor nhr-48 0.0081 0.0569 0.0736
Loa Loa (eye worm) steroid hormone receptor 0.0172 0.1562 0.4206
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Mycobacterium ulcerans inosine 5-monophosphate dehydrogenase 0.0134 0.1145 0.2264
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0099 0.0763 0.0997
Onchocerca volvulus 0.0038 0.0099 0.0285
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Loa Loa (eye worm) IMP dehydrogenase 1 0.0134 0.1145 0.3085
Echinococcus multilocularis microtubule associated protein 2 0.0729 0.7654 0.845
Schistosoma mansoni thyroid hormone receptor 0.0172 0.1562 0.2034
Brugia malayi hypothetical protein 0.0091 0.0675 0.1701
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0329 0.0422
Schistosoma mansoni jumonji domain containing protein 0.0154 0.1364 0.1775
Plasmodium falciparum phd finger protein, putative 0.0059 0.0329 0.1466
Mycobacterium tuberculosis Probable inosine-5'-monophosphate dehydrogenase GuaB3 (imp dehydrogenase) (inosinic acid dehydrogenase) (inosinate dehydrogenase 0.0075 0.0499 0.0866
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0099 0.0763 0.0843
Loa Loa (eye worm) hypothetical protein 0.0091 0.0675 0.1818
Echinococcus granulosus fetal alzheimer antigen falz 0.0117 0.0967 0.1264
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0461 0.4723 1
Brugia malayi nuclear receptor NHR-67 0.0081 0.0569 0.1432
Loa Loa (eye worm) hypothetical protein 0.0038 0.0099 0.0266
Brugia malayi beta-lactamase family protein 0.0038 0.0099 0.0243
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.003 0.0014 0.001
Brugia malayi RNA binding protein 0.0279 0.2736 0.6914
Brugia malayi Nuclear hormone receptor-like 1 0.0172 0.1562 0.3943
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0172 0.1562 0.4206
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0172 0.1562 0.204
Loa Loa (eye worm) hypothetical protein 0.0091 0.0675 0.1818
Trypanosoma cruzi ISWI complex protein 0.008 0.0554 0.2502
Schistosoma mansoni hypothetical protein 0.0724 0.7605 0.9935
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0099 0.0121
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0329 0.0363
Echinococcus granulosus transient receptor potential ion channel A 0.0103 0.0815 0.1064
Schistosoma mansoni methyl-cpg binding protein mbd 0.0089 0.0654 0.0848
Echinococcus multilocularis FTZ F1 alpha 0.0172 0.1562 0.1724
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.0892
Loa Loa (eye worm) hypothetical protein 0.0091 0.0675 0.1818
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0091 0.0675 0.0875
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0081 0.0569 0.0628
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0172 0.1562 0.3943
Onchocerca volvulus 0.0172 0.1562 0.478
Brugia malayi orphan nuclear receptor NR2E1 0.0081 0.0569 0.1432
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.1017 0.2738
Schistosoma mansoni nuclear hormone receptor 0.0172 0.1562 0.2034
Brugia malayi tailless protein 0.0081 0.0569 0.1432
Plasmodium falciparum inosine-5'-monophosphate dehydrogenase 0.0134 0.1145 0.5214
Brugia malayi TAR-binding protein 0.0279 0.2736 0.6914
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0172 0.1562 0.3943
Loa Loa (eye worm) hypothetical protein 0.0327 0.3261 0.8782
Trichomonas vaginalis CAMK family protein kinase 0.0045 0.0178 0.008
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0569 0.0736
Brugia malayi PHD-finger family protein 0.013 0.1102 0.2781
Schistosoma mansoni inosine-5-monophosphate dehydrogenase 0.0134 0.1145 0.149
Loa Loa (eye worm) nuclear receptor NHR-67 0.0081 0.0569 0.1532
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Brugia malayi jmjC domain containing protein 0.0081 0.0573 0.1444
Brugia malayi jmjC domain containing protein 0.0193 0.1799 0.4542
Echinococcus granulosus TRP transient receptor potential channel 0.004 0.0118 0.0154
Loa Loa (eye worm) hypothetical protein 0.0222 0.2113 0.5691
Onchocerca volvulus Putative GMP reductase 0.0059 0.0329 0.0992
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Echinococcus granulosus ecdysone induced protein 78C 0.0172 0.1562 0.204
Brugia malayi nuclear receptor RXR 0.0081 0.0569 0.1432
Echinococcus multilocularis inosine 5' monophosphate dehydrogenase 2 0.0134 0.1145 0.1265
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0029 0.0001 0.0002
Loa Loa (eye worm) hypothetical protein 0.0029 0.0003 0.0006
Echinococcus granulosus methyl CpG binding domain protein 2 0.0089 0.0654 0.0855
Onchocerca volvulus Bile acid receptor homolog 0.0172 0.1562 0.478
Brugia malayi photoreceptor-specific nuclear receptor 0.0172 0.1562 0.3943
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0311 0.3085 0.403
Brugia malayi conserved hypotetical protein 0.0081 0.0569 0.1432
Echinococcus granulosus peregrin 0.0071 0.0464 0.0606
Schistosoma mansoni coup transcription factor 0.0172 0.1562 0.2034
Echinococcus granulosus FTZ F1 alpha 0.0172 0.1562 0.204
Schistosoma mansoni transcription factor btf3 0.0229 0.2188 0.2853
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Onchocerca volvulus 0.0081 0.0569 0.1729
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0172 0.1562 0.3943
Echinococcus granulosus short transient receptor potential channel 6 0.0071 0.0457 0.0597
Schistosoma mansoni nuclear receptor 0.0081 0.0569 0.0736
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0076 0.0512 0.2305
Echinococcus multilocularis ecdysone induced protein 78C 0.0172 0.1562 0.1724
Toxoplasma gondii ABC1 family protein 0.0038 0.0099 0.0411
Loa Loa (eye worm) hypothetical protein 0.0091 0.0675 0.1818
Loa Loa (eye worm) bromodomain containing protein 0.0092 0.0689 0.1856
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0172 0.1562 0.4206
Loa Loa (eye worm) hypothetical protein 0.0172 0.1562 0.4206
Echinococcus granulosus tar DNA binding protein 0.0279 0.2736 0.3575
Schistosoma mansoni tar DNA-binding protein 0.0279 0.2736 0.357
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Brugia malayi inosine-5'-monophosphate dehydrogenase family protein 0.0134 0.1145 0.289
Brugia malayi nuclear hormone receptor 0.0172 0.1562 0.3943
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0076 0.0512 0.5
Mycobacterium ulcerans inosine 5'-monophosphate dehydrogenase 0.0134 0.1145 0.2264
Loa Loa (eye worm) GMP reductase 0.0059 0.0329 0.0885
Trypanosoma cruzi GMP reductase 0.0134 0.1145 0.5214
Loa Loa (eye worm) hypothetical protein 0.02 0.1869 0.5034
Echinococcus granulosus lamin dm0 0.003 0.0006 0.0008
Schistosoma mansoni RAR-like nuclear receptor 0.0172 0.1562 0.2034
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0099 0.0109
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0134 0.1145 0.5214
Leishmania major hypothetical protein, conserved 0.0038 0.0099 0.0411
Trypanosoma cruzi GMP reductase 0.0134 0.1145 0.5214
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0569 0.0743
Trypanosoma cruzi inosine-5'-monophosphate dehydrogenase, putative 0.0134 0.1145 0.5214
Loa Loa (eye worm) hypothetical protein 0.0119 0.0985 0.2654
Schistosoma mansoni hypothetical protein 0.0107 0.0858 0.1114
Entamoeba histolytica transcription factor BTF3, putative 0.0229 0.2188 0.1615
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0172 0.1562 0.3943
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0117 0.0967 0.1068
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0187 0.173 0.226
Trichomonas vaginalis CAMK family protein kinase 0.0092 0.0684 0.0591
Onchocerca volvulus 0.0038 0.0099 0.0285
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0573 0.0749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0119 0.0985 0.128
Brugia malayi nuclear hormone receptor family member odr-7 0.0081 0.0569 0.1432
Schistosoma mansoni microtubule-associated protein tau 0.0729 0.7654 1
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0943 1 1
Brugia malayi hypothetical protein 0.0327 0.3261 0.824
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0172 0.1562 0.2034
Echinococcus granulosus transient receptor potential gamma protein 0.0107 0.0854 0.1115
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0151 0.1338 0.1478
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0099 0.0411
Brugia malayi hypothetical protein 0.003 0.0009 0.0017
Brugia malayi Bromodomain containing protein 0.0391 0.3957 1
Brugia malayi hypothetical protein 0.0151 0.1338 0.3378
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0092 0.0684 0.1841
Loa Loa (eye worm) hypothetical protein 0.0081 0.0569 0.1532
Echinococcus multilocularis muscleblind protein 1 0.0151 0.1339 0.1478
Loa Loa (eye worm) hypothetical protein 0.0151 0.1339 0.3605
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0081 0.0569 0.0628
Plasmodium vivax SET domain protein, putative 0.003 0.0014 0.002
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.003 0.0014 0.002
Leishmania major hypothetical protein, conserved 0.008 0.0554 0.2502
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0172 0.1562 0.4206
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0172 0.1562 0.1724
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0172 0.1562 0.2034

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 130 nM Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay in presence of 0.05% BSA ChEMBL. 23324406
IC50 (binding) = 130 nM Inhibition of recombinant Cryptosporidium parvum IMPDH assessed as production of NADH by fluorescence assay ChEMBL. 23324406

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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