Detailed information for compound 100162

Basic information

Technical information
  • TDR Targets ID: 100162
  • Name: 4-[2-[[4-(4-fluorophenyl)-4-oxobutyl]-methyla mino]ethoxy]-1,3-dihydroindol-2-one
  • MW: 370.417 | Formula: C21H23FN2O3
  • H donors: 1 H acceptors: 2 LogP: 2.55 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 1
  • SMILES: CN(CCOc1cccc2c1CC(=O)N2)CCCC(=O)c1ccc(cc1)F
  • InChi: 1S/C21H23FN2O3/c1-24(11-3-5-19(25)15-7-9-16(22)10-8-15)12-13-27-20-6-2-4-18-17(20)14-21(26)23-18/h2,4,6-10H,3,5,11-14H2,1H3,(H,23,26)
  • InChiKey: IOVXZPKVVVPHDX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-[2-[[4-(4-fluorophenyl)-4-oxo-butyl]-methyl-amino]ethoxy]indolin-2-one
  • 4-[2-[[4-(4-fluorophenyl)-4-oxobutyl]-methylamino]ethoxy]-2-indolinone
  • 4-[2-[[4-(4-fluorophenyl)-4-oxo-butyl]-methyl-amino]ethoxy]-1,3-dihydroindol-2-one
  • 4-[2-[[4-(4-fluorophenyl)-4-keto-butyl]-methyl-amino]ethoxy]oxindole

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Adrenergic receptor alpha-1 Starlite/ChEMBL References
Rattus norvegicus Dopamine D2 receptor Starlite/ChEMBL References
Rattus norvegicus Serotonin 1a (5-HT1a) receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Schistosoma japonicum expressed protein Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum ko:K04153 5-hydroxytryptamine (serotonin) receptor 1A, putative Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus granulosus biogenic amine 5HT receptor Get druggable targets OG5_133249 All targets in OG5_133249
Echinococcus multilocularis serotonin receptor Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma mansoni biogenic amine (5HT) receptor Get druggable targets OG5_133249 All targets in OG5_133249
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_133249 All targets in OG5_133249
Schistosoma japonicum Octopamine receptor, putative Get druggable targets OG5_133249 All targets in OG5_133249
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.4 %
Schistosoma mansoni biogenic amine (dopamine) receptor Dopamine D2 receptor   444 aa 494 aa 26.3 %
Loa Loa (eye worm) hypothetical protein Serotonin 1a (5-HT1a) receptor   422 aa 388 aa 26.5 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 390 aa 33.6 %
Onchocerca volvulus RB1-inducible coiled-coil protein 1 homolog Dopamine D2 receptor   444 aa 474 aa 23.4 %
Loa Loa (eye worm) TYRA-2 protein Serotonin 1a (5-HT1a) receptor   422 aa 491 aa 27.3 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 426 aa 29.6 %
Echinococcus granulosus biogenic amine 5HT receptor Dopamine D2 receptor   444 aa 429 aa 31.7 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 407 aa 23.3 %
Schistosoma japonicum ko:K04145 dopamine receptor D2, putative Serotonin 1a (5-HT1a) receptor   422 aa 410 aa 27.8 %
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor Serotonin 1a (5-HT1a) receptor   422 aa 350 aa 20.6 %
Echinococcus multilocularis neuropeptides capa receptor Serotonin 1a (5-HT1a) receptor   422 aa 430 aa 20.0 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 433 aa 22.4 %
Schistosoma japonicum Octopamine receptor 1, putative Serotonin 1a (5-HT1a) receptor   422 aa 424 aa 24.3 %
Schistosoma japonicum ko:K04207 neuropeptide Y receptor Y5, putative Serotonin 1a (5-HT1a) receptor   422 aa 339 aa 23.0 %
Schistosoma mansoni biogenic amine receptor Dopamine D2 receptor   444 aa 452 aa 30.1 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 417 aa 21.1 %
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor Dopamine D2 receptor   444 aa 487 aa 23.8 %
Onchocerca volvulus Serotonin 1a (5-HT1a) receptor   422 aa 436 aa 23.9 %
Schistosoma japonicum IPR000276,Rhodopsin-like GPCR superfamily,domain-containing Serotonin 1a (5-HT1a) receptor   422 aa 392 aa 20.7 %
Echinococcus multilocularis g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 23.6 %
Echinococcus granulosus alpha 1A adrenergic receptor Serotonin 1a (5-HT1a) receptor   422 aa 452 aa 21.0 %
Echinococcus granulosus g protein coupled receptor Serotonin 1a (5-HT1a) receptor   422 aa 432 aa 24.3 %
Onchocerca volvulus Mitochondrial inner membrane protein homolog Serotonin 1a (5-HT1a) receptor   422 aa 383 aa 30.5 %
Echinococcus granulosus orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.0 %
Schistosoma japonicum ko:K04135 adrenergic receptor, alpha 1a, putative Serotonin 1a (5-HT1a) receptor   422 aa 448 aa 29.7 %
Echinococcus multilocularis orexin receptor type 2 Serotonin 1a (5-HT1a) receptor   422 aa 369 aa 22.2 %
Onchocerca volvulus Glycoprotein hormone beta 5 homolog Serotonin 1a (5-HT1a) receptor   422 aa 477 aa 24.3 %
Schistosoma mansoni amine GPCR Serotonin 1a (5-HT1a) receptor   422 aa 440 aa 31.6 %
Schistosoma japonicum Octopamine receptor, putative Dopamine D2 receptor   444 aa 456 aa 29.4 %
Schistosoma japonicum ko:K04136 adrenergic receptor, alpha 1b, putative Serotonin 1a (5-HT1a) receptor   422 aa 444 aa 29.3 %
Echinococcus multilocularis serotonin receptor Dopamine D2 receptor   444 aa 428 aa 31.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2149 0.3117
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.2783
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0065 0.0878 0.4587
Brugia malayi larval opioid receptor 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0107 0.1601 0.3113
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0028 0.0244 0.0297
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0065 0.0878 0.4587
Onchocerca volvulus 0.0029 0.0261 0.1174
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0016 0.0047 0.0005
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0086 0.1243 0.4061
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0065 0.0878 0.2803
Echinococcus granulosus tachykinin peptides receptor 99D 0.0016 0.0047 0.0005
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0391 0.042
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0065 0.0878 0.1235
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0391 0.113
Echinococcus multilocularis G-protein coupled receptor, putative 0.0016 0.0047 0.0005
Loa Loa (eye worm) bromodomain containing protein 0.0027 0.0238 0.0463
Onchocerca volvulus 0.0036 0.0391 0.1885
Brugia malayi CXXC zinc finger family protein 0.0029 0.0261 0.0471
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Schistosoma mansoni biogenic amine receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0047 0.0005
Mycobacterium tuberculosis Probable reductase 0.0426 0.7074 0.8958
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.184 1
Brugia malayi glutamate synthase 0.0017 0.0062 0.0041
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0047 0.0092
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.184 1
Echinococcus multilocularis G protein coupled receptor 139 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0024 0.0188 0.0366
Echinococcus multilocularis snurportin 1 0.0313 0.5141 0.7546
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Brugia malayi Dopamine receptor protein 2 0.0016 0.0047 0.0008
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0391 0.042
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0016 0.0047 0.0005
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0371 0.1772
Brugia malayi Dopamine receptor 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni amine GPCR 0.0016 0.0047 0.0047
Entamoeba histolytica Ran family GTPase 0.0022 0.0138 0.0747
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Echinococcus multilocularis apoptosis inducing factor 1 mitochondrial 0.0017 0.0062 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) neuropeptide F receptor 0.0016 0.0047 0.0092
Brugia malayi Melatonin receptor type 1A 0.0016 0.0047 0.0008
Echinococcus granulosus pyridine nucleotide disulfide oxidoreductase 0.0017 0.0062 0.0028
Echinococcus granulosus geminin 0.0332 0.5467 0.803
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0062 0.0041
Brugia malayi Calcitonin receptor-like protein seb-1 0.0107 0.1601 0.3363
Echinococcus multilocularis serotonin receptor 0.0163 0.2571 0.3742
Loa Loa (eye worm) MH2 domain-containing protein 0.0016 0.0044 0.0085
Loa Loa (eye worm) hypothetical protein 0.0123 0.1873 0.3643
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0473 0.7889 1
Loa Loa (eye worm) hypothetical protein 0.0082 0.1173 0.2283
Toxoplasma gondii ABC1 family protein 0.0036 0.0391 0.113
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0062 0.0062
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Brugia malayi Tachykinin-like peptides receptor 99D 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0047 0.0047
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0016 0.0047 0.0092
Echinococcus multilocularis g-protein coupled receptor 0.0016 0.0047 0.0005
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0138 0.0261
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Loa Loa (eye worm) programmed cell death 8 0.0017 0.0062 0.0121
Schistosoma mansoni glutamate synthase 0.0017 0.0062 0.0062
Leishmania major trypanothione reductase 0.0187 0.2971 1
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0065 0.0878 0.2803
Giardia lamblia Pyruvate kinase 0.0018 0.0077 0.0146
Loa Loa (eye worm) Smad1 0.0016 0.0044 0.0085
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0138 0.0261
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0016 0.0047 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0016 0.0047 0.0005
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0047 0.0047
Mycobacterium ulcerans pyruvate kinase 0.0035 0.0371 0.1734
Echinococcus granulosus g protein coupled receptor 0.0016 0.0047 0.0005
Toxoplasma gondii thioredoxin reductase 0.0187 0.2971 1
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0391 0.185
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0371 0.0721
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0047 0.0047
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.042
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2149 0.2149
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0016 0.0047 0.0092
Brugia malayi Serotonin receptor 0.0016 0.0047 0.0008
Brugia malayi beta-lactamase family protein 0.0036 0.0391 0.0751
Trichomonas vaginalis glutathione reductase, putative 0.0065 0.0878 0.6903
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.073 0.5654
Entamoeba histolytica pyruvate kinase, putative 0.0024 0.0188 0.1239
Brugia malayi NADPH:adrenodoxin oxidoreductase, mitochondrial precursor 0.0017 0.0062 0.0041
Schistosoma mansoni Smad4 0.0016 0.0044 0.0044
Echinococcus multilocularis pyruvate kinase 0.0018 0.0077 0.005
Schistosoma mansoni opsin-like receptor 0.0016 0.0047 0.0047
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0121 0.184 0.2659
Brugia malayi RNA, U transporter 1 0.0083 0.1199 0.2496
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Brugia malayi ORL1-like opioid receptor 0.0016 0.0047 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.0878 1
Echinococcus granulosus allatostatin A receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0056 0.073 0.142
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0047 0.0005
Plasmodium vivax pyruvate kinase, putative 0.0035 0.0371 0.106
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0121 0.184 0.6112
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) thioredoxin reductase 0.0187 0.2971 0.5779
Schistosoma mansoni hypothetical protein 0.0332 0.5467 0.5467
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0042 0.0482 0.0649
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0047 0.0005
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0056 0.073 0.1017
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis geminin 0.0332 0.5467 0.803
Echinococcus granulosus dnaJ subfamily B 0.041 0.6798 1
Mycobacterium ulcerans hypothetical protein 0.0036 0.0391 0.185
Echinococcus multilocularis glutamate synthase 0.0017 0.0062 0.0028
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni glutamate synthase 0.0017 0.0062 0.0062
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0348 0.045
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0348 0.0657
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni sulfide quinone reductase 0.0017 0.0062 0.0062
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0138 0.0269
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0371 0.2609
Trichomonas vaginalis bromodomain-containing protein, putative 0.0086 0.1243 1
Loa Loa (eye worm) TYRA-2 protein 0.0016 0.0047 0.0092
Leishmania major pyruvate kinase 0.0035 0.0371 0.106
Echinococcus granulosus methyl CpG binding domain protein 2 0.002 0.0107 0.0094
Schistosoma mansoni ap endonuclease 0.0056 0.073 0.073
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0086 0.1243 0.4061
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.042
Echinococcus granulosus orexin receptor type 2 0.0016 0.0047 0.0005
Entamoeba histolytica acetyltransferase, GNAT family 0.0076 0.1077 1
Brugia malayi sulfakinin receptor protein 0.0016 0.0047 0.0008
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0176 0.0961
Brugia malayi G-protein coupled receptor 0.0016 0.0047 0.0008
Plasmodium falciparum pyruvate kinase 0.0035 0.0371 0.106
Echinococcus multilocularis somatostatin receptor 0.0016 0.0047 0.0005
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0271 0.0718
Loa Loa (eye worm) hypothetical protein 0.002 0.0118 0.0229
Onchocerca volvulus Huntingtin homolog 0.0123 0.1873 1
Brugia malayi G-protein coupled receptor 0.0016 0.0047 0.0008
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0016 0.0047 0.0005
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0107 0.1601 0.3363
Schistosoma mansoni amine GPCR 0.0016 0.0047 0.0047
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0016 0.0047 0.0005
Schistosoma mansoni hypothetical protein 0.0034 0.0348 0.0348
Echinococcus granulosus neuropeptide receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.002 0.0118 0.011
Echinococcus multilocularis pyridine nucleotide disulfide oxidoreductase 0.0017 0.0062 0.0028
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0016 0.0047 0.0005
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0878 0.2803
Echinococcus granulosus g protein coupled receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0016 0.0047 0.0005
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0107 0.0107
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Echinococcus granulosus pyruvate kinase 0.0035 0.0371 0.0484
Echinococcus granulosus peptide allatostatin:somatostatin 0.0016 0.0047 0.0005
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0138 0.0261
Schistosoma mansoni bromodomain containing protein 0.0082 0.1173 0.1173
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0348 0.0657
Echinococcus granulosus histone acetyltransferase KAT2B 0.0086 0.1243 0.1776
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1021 0.2111
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0348 0.045
Plasmodium falciparum thioredoxin reductase 0.0187 0.2971 1
Schistosoma mansoni disulfide oxidoreductase 0.0017 0.0062 0.0062
Brugia malayi hypothetical protein 0.0123 0.1873 0.3951
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0047 0.0005
Trichomonas vaginalis esterase, putative 0.0036 0.0391 0.2783
Echinococcus granulosus hypothetical protein 0.0016 0.0047 0.0005
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0391 0.0391
Brugia malayi Dopamine receptor protein 1 0.0016 0.0047 0.0008
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.184 0.184
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0086 0.1243 1
Trypanosoma cruzi ISWI complex protein 0.0018 0.0072 0.0033
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0047 0.0092
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0056 0.073 0.0853
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0391 0.113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0348 0.045
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0187 0.2971 0.3716
Toxoplasma gondii NADPH-glutathione reductase 0.0065 0.0878 0.2803
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0391 0.042
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0016 0.0047 0.0047
Trypanosoma cruzi ISWI complex protein 0.0018 0.0072 0.0033
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0286 0.4673 0.6853
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0391 0.042
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0078 0.1102 0.1566
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0047 0.0005
Schistosoma mansoni importin beta-1 0.0029 0.0271 0.0271
Schistosoma mansoni neuropeptide receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0062 0.0028
Schistosoma mansoni neuropeptide receptor 0.0016 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0332 0.5467 0.5467
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0878 0.2803
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Mycobacterium tuberculosis Conserved protein 0.0036 0.0391 0.042
Schistosoma mansoni biogenic amine (5HT) receptor 0.0163 0.2571 0.2571
Schistosoma mansoni ap endonuclease 0.0056 0.073 0.073
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0056 0.073 0.2296
Loa Loa (eye worm) hypothetical protein 0.0029 0.0271 0.0527
Schistosoma mansoni zinc finger protein 0.0031 0.0304 0.0304
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0426 0.7074 0.8958
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Chlamydia trachomatis pyruvate kinase 0.0035 0.0371 0.378
Echinococcus granulosus histone lysine methyltransferase setb 0.002 0.0118 0.011
Echinococcus granulosus alpha 1A adrenergic receptor 0.0016 0.0047 0.0005
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0878 0.2803
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0473 0.7889 1
Onchocerca volvulus 0.0036 0.0391 0.1885
Echinococcus multilocularis dro:myosuppressin receptor 0.0016 0.0047 0.0005
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Trypanosoma brucei pyruvate kinase 1, putative 0.0035 0.0371 0.106
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0118 0.0118
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0138 0.0261
Onchocerca volvulus 0.0036 0.0391 0.1885
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0028 0.0244 0.0244
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0869 0.2774
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0024 0.0176 0.0961
Brugia malayi Pyruvate kinase, muscle isozyme 0.0035 0.0371 0.0707
Brugia malayi Pyruvate kinase, M2 isozyme 0.0035 0.0371 0.0707
Plasmodium vivax pyruvate kinase 2, putative 0.0018 0.0077 0.0051
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0065 0.0878 0.2803
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0232 0.375 0.4712
Schistosoma mansoni smad 0.0016 0.0044 0.0044
Echinococcus multilocularis neuropeptides capa receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) pyruvate kinase-PB 0.0024 0.0188 0.0366
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Echinococcus granulosus glutamate synthase 0.0017 0.0062 0.0028
Echinococcus multilocularis neuropeptide FF receptor 2 0.0016 0.0047 0.0005
Mycobacterium ulcerans aldehyde dehydrogenase 0.0121 0.184 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0065 0.0878 0.2803
Echinococcus granulosus sex peptide receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0047 0.0005
Plasmodium falciparum glutathione reductase 0.0065 0.0878 0.2803
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Plasmodium vivax thioredoxin reductase, putative 0.0187 0.2971 1
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Mycobacterium ulcerans beta-lactamase 0.0036 0.0391 0.185
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0371 0.106
Schistosoma mansoni cpg binding protein 0.0033 0.0328 0.0328
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0391 0.0391
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Schistosoma mansoni neuropeptide receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0047 0.0005
Echinococcus granulosus GPCR family 2 0.0034 0.0348 0.045
Echinococcus granulosus histone acetyltransferase KAT2B 0.0275 0.449 0.6582
Echinococcus granulosus dro:myosuppressin receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis neuropeptide receptor A26 0.0016 0.0047 0.0005
Plasmodium falciparum histone acetyltransferase GCN5 0.0076 0.1077 0.349
Schistosoma mansoni biogenic amine receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0042 0.0482 0.0649
Schistosoma mansoni adenoreceptor 0.0016 0.0047 0.0047
Toxoplasma gondii pyruvate kinase PyKII 0.0018 0.0077 0.0051
Brugia malayi RE15519p 0.0016 0.0047 0.0008
Mycobacterium tuberculosis Probable oxidoreductase 0.0473 0.7889 1
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0391 0.2783
Echinococcus multilocularis pyruvate kinase 0.0028 0.0244 0.0296
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0391 0.2783
Brugia malayi G protein-coupled receptor 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0065 0.0878 0.2803
Brugia malayi Bromodomain containing protein 0.0095 0.1406 0.2942
Echinococcus granulosus zinc finger protein 0.0031 0.0304 0.0386
Loa Loa (eye worm) hypothetical protein 0.0123 0.1873 0.3643
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0086 0.1243 0.4061
Echinococcus granulosus neuropeptide receptor A26 0.0016 0.0047 0.0005
Toxoplasma gondii pyruvate kinase PyK1 0.0035 0.0371 0.106
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus granulosus fmrfamide receptor 0.0016 0.0047 0.0005
Brugia malayi exodeoxyribonuclease III family protein 0.0056 0.073 0.1483
Schistosoma mansoni alpha-1 adrenergic receptor 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0073 0.1021 0.1985
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis dnaJ subfamily B 0.041 0.6798 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0426 0.7074 0.8958
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0121 0.184 0.2271
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0391 0.113
Loa Loa (eye worm) hypothetical protein 0.0163 0.2571 0.5002
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0056 0.073 0.6579
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0016 0.0047 0.0008
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0286 0.4673 0.4673
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0016 0.0047 0.0047
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0056 0.073 0.2296
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0121 0.184 0.2659
Schistosoma mansoni myosin xvIII 0.0016 0.0047 0.0047
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0426 0.7074 0.8958
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Brugia malayi putative neuropeptide receptor NPR1 0.0016 0.0047 0.0008
Schistosoma mansoni biogenic amine (5HT) receptor 0.0016 0.0047 0.0047
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2149 0.3117
Echinococcus multilocularis neuropeptide s receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Giardia lamblia Pyruvate kinase 0.0035 0.0371 0.3036
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0016 0.0047 0.0005
Echinococcus granulosus g-protein coupled receptor 0.0016 0.0047 0.0005
Echinococcus multilocularis dihydropyrimidine dehydrogenase (NADP+) 0.0017 0.0062 0.0028
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Schistosoma mansoni methyl-cpg binding protein mbd 0.002 0.0107 0.0107
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0391 0.0515
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0138 0.014
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0047 0.0005
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.073 0.2296
Giardia lamblia Histone acetyltransferase GCN5 0.0076 0.1077 1
Schistosoma mansoni pyruvate kinase 0.0018 0.0077 0.0077
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Mycobacterium tuberculosis Probable dehydrogenase 0.0426 0.7074 0.8958
Treponema pallidum exodeoxyribonuclease (exoA) 0.0056 0.073 0.819
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0056 0.073 0.6579
Plasmodium falciparum pyruvate kinase 2 0.0018 0.0077 0.0051
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Schistosoma mansoni ran 0.0022 0.0138 0.0138
Schistosoma mansoni neuropeptide receptor 0.0016 0.0047 0.0047
Echinococcus granulosus cpg binding protein 0.0033 0.0328 0.0421
Schistosoma mansoni cpg binding protein 0.0029 0.0261 0.0261
Trypanosoma brucei trypanothione reductase 0.0187 0.2971 1
Schistosoma mansoni hypothetical protein 0.0073 0.1021 0.1021
Toxoplasma gondii aldehyde dehydrogenase 0.0121 0.184 0.6112
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0371 0.0721
Plasmodium falciparum glutathione reductase 0.0187 0.2971 1
Loa Loa (eye worm) hypothetical protein 0.0017 0.0062 0.0121
Schistosoma mansoni pyruvate kinase 0.0035 0.0371 0.0371
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0371 0.1772
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0016 0.0047 0.0047
Brugia malayi Thioredoxin reductase 0.0187 0.2971 0.6323
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.002 0.0118 0.0118
Echinococcus granulosus 7tm_1 domain containing protein 0.0016 0.0047 0.0005
Trichomonas vaginalis importin beta-1, putative 0.0024 0.0176 0.0961
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) PHD-finger family protein 0.0024 0.0178 0.0346
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0047 0.0005
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0065 0.0878 0.2803
Schistosoma mansoni hypothetical protein 0.041 0.6798 0.6798
Loa Loa (eye worm) G-protein coupled receptor 0.0016 0.0047 0.0092
Treponema pallidum NADH oxidase 0.0065 0.0878 1
Trichomonas vaginalis ap endonuclease, putative 0.0056 0.073 0.5654
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0348 0.045
Echinococcus multilocularis zinc finger protein 0.0031 0.0304 0.0386
Trypanosoma brucei ISWI complex protein 0.0018 0.0072 0.0033
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0391 0.042
Schistosoma mansoni hypothetical protein 0.0018 0.0072 0.0072
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0016 0.0047 0.0005
Echinococcus granulosus pyruvate kinase 0.0035 0.0371 0.0484
Brugia malayi acetyltransferase, GNAT family protein 0.0286 0.4673 1
Brugia malayi putative neuropeptide receptor 0.0016 0.0047 0.0008
Trichomonas vaginalis pyruvate kinase, putative 0.0035 0.0371 0.2609
Trichomonas vaginalis ran, putative 0.0022 0.0138 0.0642
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0391 0.0751
Loa Loa (eye worm) melatonin receptor type 1A 0.0016 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0056 0.073 0.1017
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0139 0.2149 0.418
Loa Loa (eye worm) pyruvate kinase 0.0035 0.0371 0.0721
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni biogenic amine receptor 0.0016 0.0047 0.0047
Echinococcus granulosus NADPH:adrenodoxin oxidoreductase 0.0017 0.0062 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.0878 0.2803
Onchocerca volvulus Pyruvate kinase homolog 0.0035 0.0371 0.1772
Loa Loa (eye worm) hypothetical protein 0.0163 0.2571 0.5002
Trypanosoma cruzi pyruvate kinase 2, putative 0.0035 0.0371 0.106
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Echinococcus multilocularis cpg binding protein 0.0033 0.0328 0.0421
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni ran 0.0022 0.0138 0.0138
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0056 0.073 0.819
Echinococcus granulosus somatostatin receptor 0.0016 0.0047 0.0005
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0047 0.0005
Trichomonas vaginalis mercuric reductase, putative 0.0065 0.0878 0.6903
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0016 0.0047 0.0005
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0065 0.0878 0.1802
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0047 0.0005
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0138 0.014
Echinococcus granulosus 7TM GPCR rhodopsin 0.0016 0.0047 0.0005
Schistosoma mansoni hypothetical protein 0.0017 0.0062 0.0062
Echinococcus multilocularis orexin receptor type 2 0.0016 0.0047 0.0005
Trypanosoma brucei pyruvate kinase 1 0.0035 0.0371 0.106
Echinococcus multilocularis pyruvate kinase 0.0018 0.0077 0.005
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0138 0.0205
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0065 0.0878 0.4587
Loa Loa (eye worm) hypothetical protein 0.0035 0.0371 0.0721
Echinococcus granulosus fetal alzheimer antigen falz 0.0028 0.0244 0.0297
Loa Loa (eye worm) pyridine nucleotide-disufhide oxidoreductase 0.0017 0.0062 0.0121
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2149 0.2149
Leishmania major importin beta-1 subunit, putative 0.0024 0.0176 0.039
Loa Loa (eye worm) MH1 domain-containing protein 0.0016 0.0044 0.0085
Echinococcus granulosus g protein coupled receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0016 0.0047 0.0092
Echinococcus granulosus importin subunit beta 1 0.0029 0.0271 0.0337
Echinococcus granulosus G protein coupled receptor 139 0.0016 0.0047 0.0005
Plasmodium falciparum importin beta, putative 0.0029 0.0271 0.0718
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0047 0.0005
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0139 0.2149 0.2149
Schistosoma mansoni hypothetical protein 0.0034 0.0348 0.0348
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0016 0.0047 0.0005
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0878 0.2803
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0426 0.7074 0.8958
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0391 0.0515
Loa Loa (eye worm) glutathione reductase 0.0187 0.2971 0.5779
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0056 0.073 0.2296
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0016 0.0047 0.0008
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0138 0.0747
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Echinococcus multilocularis fmrfamide receptor 0.0016 0.0047 0.0005
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0391 0.113
Mycobacterium leprae Probable lipase LipE 0.0036 0.0391 0.042
Mycobacterium leprae conserved hypothetical protein 0.0036 0.0391 0.042
Echinococcus granulosus neuropeptide FF receptor 2 0.0016 0.0047 0.0005
Echinococcus multilocularis thioredoxin glutathione reductase 0.0188 0.2989 0.436
Schistosoma mansoni zinc finger protein 0.0018 0.0072 0.0072
Loa Loa (eye worm) hypothetical protein 0.0044 0.053 0.1032
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0016 0.0047 0.0047
Schistosoma mansoni cpg binding protein 0.0033 0.0328 0.0328
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0056 0.073 0.2296
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase family protein 0.0017 0.0062 0.0041
Leishmania major hypothetical protein, conserved 0.0036 0.0391 0.113
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0139 0.2149 0.3117
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0391 0.042
Loa Loa (eye worm) acetyltransferase 0.0286 0.4673 0.909
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0878 0.2803
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0062 0.0028
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0016 0.0047 0.0092
Echinococcus multilocularis pyruvate kinase 0.0018 0.0077 0.005
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0065 0.0878 1
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0034 0.0348 0.0676
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0016 0.0047 0.0047
Brugia malayi glutathione reductase 0.0187 0.2971 0.6323
Schistosoma mansoni pyruvate kinase 0.0035 0.0371 0.0371
Loa Loa (eye worm) hypothetical protein 0.0058 0.0763 0.1483
Echinococcus granulosus dihydropyrimidine dehydrogenase NADP 0.0017 0.0062 0.0028
Trypanosoma cruzi trypanothione reductase, putative 0.0187 0.2971 1
Echinococcus multilocularis sex peptide receptor 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0054 0.0696 0.1355
Schistosoma mansoni amine GPCR 0.0016 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0034 0.0348 0.0348
Schistosoma mansoni opsin-like receptor 0.0016 0.0047 0.0047
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0047 0.0047
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.2783
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0391 0.2783
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0056 0.073 0.2296
Brugia malayi neuropeptide F receptor 0.0016 0.0047 0.0008
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Brugia malayi MH2 domain containing protein 0.0236 0.3814 0.8146
Plasmodium vivax importin-beta 2, putative 0.0029 0.0271 0.0718
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Echinococcus multilocularis serotonin receptor 0.0163 0.2571 0.3742
Echinococcus granulosus rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0473 0.7889 1
Brugia malayi GnHR receptor homolog 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Echinococcus granulosus neuropeptides capa receptor 0.0016 0.0047 0.0005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0139 0.2149 0.4548
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0426 0.7074 0.8958
Echinococcus multilocularis pyruvate kinase 0.0035 0.0371 0.0484
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Brugia malayi follicle stimulating hormone receptor 0.0016 0.0047 0.0008
Echinococcus granulosus biogenic amine 5HT receptor 0.0163 0.2571 0.3742
Echinococcus granulosus sulfide:quinone oxidoreductase 0.0017 0.0062 0.0028
Schistosoma mansoni histamine h1 receptor 0.0016 0.0047 0.0047
Echinococcus granulosus neuropeptide s receptor 0.0016 0.0047 0.0005
Echinococcus granulosus pyruvate kinase 0.0018 0.0077 0.005
Brugia malayi AKH receptor 0.0016 0.0047 0.0008
Brugia malayi neuropeptide F receptor 0.0016 0.0047 0.0008
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0047 0.0583 0.1166
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0271 0.0718
Onchocerca volvulus 0.0017 0.0062 0.0084
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0016 0.0047 0.0005
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0047 0.0583 0.1166
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Brugia malayi Serotonin receptor 0.0016 0.0047 0.0008
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0056 0.073 0.3757
Schistosoma mansoni glutamate synthase 0.0017 0.0062 0.0062
Echinococcus multilocularis pyruvate kinase 0.0035 0.0371 0.0484
Echinococcus granulosus neuropeptide receptor 0.0016 0.0047 0.0005
Mycobacterium ulcerans lipase LipD 0.0036 0.0391 0.185
Echinococcus granulosus serotonin receptor 0.0016 0.0047 0.0005
Leishmania major hypothetical protein, conserved 0.0018 0.0072 0.0033
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0139 0.2149 0.3117
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Brugia malayi hypothetical protein 0.0016 0.0047 0.0008
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0016 0.0047 0.0047
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0313 0.5141 1
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0016 0.0047 0.0047
Echinococcus multilocularis rhodopsin orphan GPCR 0.0016 0.0047 0.0005
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0016 0.0047 0.0092
Schistosoma mansoni hypothetical protein 0.0034 0.0348 0.0348
Echinococcus granulosus apoptosis inducing factor 1 mitochondrial 0.0017 0.0062 0.0028
Echinococcus granulosus snurportin 1 0.0313 0.5141 0.7546
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0065 0.0878 0.2803
Schistosoma mansoni amine GPCR 0.0016 0.0047 0.0047
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0065 0.0878 0.1042
Schistosoma mansoni amine GPCR 0.0016 0.0047 0.0047
Schistosoma mansoni smad1 5 8 and 0.0016 0.0044 0.0044
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Brugia malayi Importin beta-1 subunit 0.0029 0.0271 0.0492
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Brugia malayi G protein-coupled receptor F59B2.13 0.0016 0.0047 0.0008
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0065 0.0878 0.1235
Schistosoma mansoni neuropeptide f receptor 76f 0.0016 0.0047 0.0047
Echinococcus multilocularis allatostatin A receptor 0.0016 0.0047 0.0005
Schistosoma mansoni smad1 5 8 and 0.0016 0.0044 0.0044
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0016 0.0044 0.0044
Echinococcus multilocularis neuropeptide Y receptor 0.0016 0.0047 0.0005
Brugia malayi beta-lactamase 0.0036 0.0391 0.0751
Schistosoma mansoni hypothetical protein 0.0313 0.5141 0.5141
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0016 0.0047 0.0008
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0016 0.0047 0.0047
Schistosoma mansoni hypothetical protein 0.0024 0.0178 0.0178
Onchocerca volvulus Huntingtin homolog 0.0123 0.1873 1
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0348 0.0676
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Schistosoma mansoni growth hormone secretagogue receptor 0.0016 0.0047 0.0047
Brugia malayi PHD-finger family protein 0.0037 0.041 0.0792
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0016 0.0047 0.0047
Entamoeba histolytica hypothetical protein 0.0024 0.0176 0.1118
Leishmania major GTP-binding protein, putative 0.0022 0.0138 0.0261
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0016 0.0047 0.0008
Schistosoma mansoni neuropeptide F-like receptor 0.0016 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0036 0.0391 0.0761
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Echinococcus multilocularis g protein coupled receptor 0.0016 0.0047 0.0005
Schistosoma mansoni aldehyde dehydrogenase 0.0121 0.184 0.184
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0391 0.0761
Echinococcus multilocularis NADPH:adrenodoxin oxidoreductase 0.0017 0.0062 0.0028
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0065 0.0878 0.2803
Brugia malayi beta-lactamase family protein 0.0036 0.0391 0.0751
Brugia malayi Bromodomain containing protein 0.0051 0.0648 0.1306
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0391 0.185
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0271 0.0337
Echinococcus granulosus pyruvate kinase 0.0018 0.0077 0.005
Loa Loa (eye worm) MH2 domain-containing protein 0.0236 0.3814 0.742
Trypanosoma cruzi importin beta-1 subunit, putative 0.0024 0.0176 0.039
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0065 0.0878 0.2803
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0065 0.0878 0.0878
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Plasmodium vivax glutathione reductase, putative 0.0187 0.2971 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0188 0.2989 0.436
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0065 0.0878 1
Giardia lamblia NADH oxidase lateral transfer candidate 0.0065 0.0878 0.8033
Leishmania major pyruvate kinase 0.0035 0.0371 0.106
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0107 0.1601 0.3113
Echinococcus granulosus pyruvate kinase 0.0018 0.0077 0.005
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0271 0.0718
Echinococcus multilocularis sulfide:quinone oxidoreductase 0.0017 0.0062 0.0028
Toxoplasma gondii exonuclease III APE 0.0056 0.073 0.2296
Echinococcus multilocularis GPCR, family 2 0.0034 0.0348 0.045
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0078 0.1102 0.1566
Plasmodium falciparum thioredoxin reductase 0.0065 0.0878 0.2803
Echinococcus multilocularis methyl CpG binding domain protein 2 0.002 0.0107 0.0094
Echinococcus granulosus neuropeptide Y receptor 0.0016 0.0047 0.0005
Schistosoma mansoni smad1 5 8 and 0.0016 0.0044 0.0044
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0016 0.0047 0.0005
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0261 0.0509
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0138 0.0261
Schistosoma mansoni opsin-like receptor 0.0016 0.0047 0.0047
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0138 0.0261
Echinococcus multilocularis neuropeptide receptor 0.0016 0.0047 0.0005
Mycobacterium tuberculosis Probable pyruvate kinase PykA 0.0035 0.0371 0.0394
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0061 0.0815 0.0815
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0391 0.042
Mycobacterium leprae Probable pyruvate kinase PykA 0.0035 0.0371 0.0394
Loa Loa (eye worm) hypothetical protein 0.0016 0.0047 0.0092
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0016 0.0047 0.0005
Loa Loa (eye worm) beta-lactamase 0.0036 0.0391 0.0761
Loa Loa (eye worm) transcription factor SMAD2 0.0236 0.3814 0.742
Schistosoma mansoni hypothetical protein 0.0016 0.0047 0.0047
Echinococcus granulosus tm gpcr rhodopsin 0.0016 0.0047 0.0005

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 3.1 nM In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranes ChEMBL. 10354409
Ki (binding) = 3.1 nM In vitro high binding affinity towards Dopamine receptor D2 by the displacement of [3H]-quinpirole radioligand in rat striatal membranes ChEMBL. 10354409
Ki (binding) = 9.5 nM In vitro binding affinity towards alpha-1 adrenergic receptor by the displacement of [3H]-prazosin radioligand in rat cortical homogenates ChEMBL. 10354409
Ki (binding) = 9.5 nM In vitro binding affinity towards alpha-1 adrenergic receptor by the displacement of [3H]-prazosin radioligand in rat cortical homogenates ChEMBL. 10354409
Ki (binding) = 24.1 nM In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranes ChEMBL. 10354409
Ki (binding) = 24.1 nM In vitro low binding affinity towards Dopamine receptor D2 by the displacement of [3H]-spiperone radioligand in rat striatal membranes ChEMBL. 10354409
Ki (binding) = 253 nM In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenates ChEMBL. 10354409
Ki (binding) = 253 nM In vitro binding affinity towards 5-hydroxytryptamine 1A receptor by the displacement of [3H]-8-OH-DPAT radioligand in rat hippocampal homogenates ChEMBL. 10354409
Ratio (binding) = 8 Ratio of Dopamine D2 receptor (low)and Dopamine D2 receptor (high) ChEMBL. 10354409
Ratio (binding) = 8 Ratio of Dopamine D2 receptor (low)and Dopamine D2 receptor (high) ChEMBL. 10354409

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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