Detailed information for compound 1001713

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 267.255 | Formula: C16H10FNO2
  • H donors: 0 H acceptors: 1 LogP: 3.77 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Fc1ccc2c(c1)ccc(n2)c1ccc2c(c1)OCO2
  • InChi: 1S/C16H10FNO2/c17-12-3-5-14-10(7-12)1-4-13(18-14)11-2-6-15-16(8-11)20-9-19-15/h1-8H,9H2
  • InChiKey: LZWFNPNJLZKXLV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans beta-lactamase 0.0036 0.031 0.131
Plasmodium vivax hypothetical protein, conserved 0.0036 0.031 0.266
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0055
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.031 0.031
Onchocerca volvulus 0.0036 0.031 0.0319
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 0.5532
Echinococcus multilocularis geminin 0.0747 1 1
Schistosoma mansoni transcription factor LCR-F1 0.004 0.037 0.037
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.031 0.0884
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.031 0.131
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.011 0.1315 0.1315
Onchocerca volvulus 0.0036 0.031 0.0319
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0027 0.0183 0.0444
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0057 0.0603 0.1899
Echinococcus granulosus GPCR family 2 0.0034 0.0278 0.0278
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2665 0.2665
Entamoeba histolytica hypothetical protein 0.004 0.037 0.0519
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0142 0.176 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0184
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.1263 0.2925
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0111 0.1331 0.1331
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0026 0.0179 0.0389
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Entamoeba histolytica hypothetical protein 0.004 0.037 0.0519
Plasmodium falciparum acyl-CoA synthetase 0.002 0.0092 0.0383
Loa Loa (eye worm) jmjC domain-containing protein 0.0041 0.0379 0.0857
Schistosoma mansoni hypothetical protein 0.004 0.037 0.037
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2665 0.2665
Echinococcus granulosus peptidase Clp S14 family 0.0057 0.0603 0.0603
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1014 0.652
Brugia malayi hypothetical protein 0.0019 0.0079 0.0154
Schistosoma mansoni intermediate filament proteins 0.0026 0.0179 0.0179
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.031 0.031
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.031 0.0695
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2665 0.2665
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.003 0.0232 0.185
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Brugia malayi RNA binding protein 0.0209 0.2665 0.6204
Echinococcus multilocularis GPCR, family 2 0.0034 0.0278 0.0278
Brugia malayi serine/threonine-protein kinase plk-2 0.011 0.1315 0.3046
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.031 0.0695
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Echinococcus multilocularis peregrin 0.0034 0.0282 0.0282
Toxoplasma gondii aldehyde dehydrogenase 0.0125 0.1527 1
Brugia malayi Inositol-1 0.0039 0.0357 0.0805
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0035 0.0301 0.0749
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.003 0.0232 0.0313
Onchocerca volvulus 0.0328 0.4288 1
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.004 0.037 0.037
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0055
Mycobacterium ulcerans hypothetical protein 0.0036 0.031 0.131
Loa Loa (eye worm) hypothetical protein 0.0058 0.0612 0.14
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0183 0.0871
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0017 0.0055 0.0055
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0039 0.0357 0.0483
Schistosoma mansoni hypothetical protein 0.0747 1 1
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0183 0.0398
Brugia malayi Latrophilin receptor protein 2 0.0034 0.0278 0.0619
Echinococcus multilocularis jumonji domain containing protein 0.0047 0.0463 0.0463
Onchocerca volvulus 0.0027 0.0183 0.001
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0183 0.0871
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.2966 0.6907
Entamoeba histolytica hypothetical protein 0.004 0.037 0.0519
Loa Loa (eye worm) RNA binding protein 0.0209 0.2665 0.6204
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0057 0.0603 0.2666
Echinococcus multilocularis lysine specific demethylase 5A 0.0041 0.0379 0.0379
Brugia malayi follicle stimulating hormone receptor 0.0231 0.2966 0.6907
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.0278 0.0619
Loa Loa (eye worm) isocitrate dehydrogenase 0.0017 0.0055 0.0098
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0278
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0183 0.0398
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0077 0.0076
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0398
Echinococcus multilocularis peptidase Clp (S14 family) 0.0057 0.0603 0.0603
Mycobacterium leprae Probable lipase LipE 0.0036 0.031 0.0806
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0357 0.2055
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0017 0.0055 0.0055
Echinococcus granulosus intermediate filament protein 0.0026 0.0179 0.0179
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.003 0.0232 0.185
Loa Loa (eye worm) intermediate filament protein 0.0026 0.0179 0.0389
Echinococcus multilocularis tar DNA binding protein 0.0209 0.2665 0.2665
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.031 0.0884
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0561 0.072
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.031 0.0884
Loa Loa (eye worm) TAR-binding protein 0.0209 0.2665 0.6204
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0027 0.0183 0.0548
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.1263 0.2925
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.031 0.2026
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.0278 0.0278
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0111 0.1331 0.1331
Giardia lamblia Fructose-bisphosphate aldolase 0.0291 0.3789 1
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Mycobacterium tuberculosis Conserved protein 0.0036 0.031 0.0884
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.031 0.2026
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0184
Brugia malayi RNA recognition motif domain containing protein 0.0209 0.2665 0.6204
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1527 0.8603
Loa Loa (eye worm) hypothetical protein 0.0034 0.0282 0.063
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0282 0.1546
Echinococcus granulosus jumonji domain containing protein 0.0047 0.0463 0.0463
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1725 0.1725
Echinococcus multilocularis musashi 0.0026 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0398
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0357 0.24
Loa Loa (eye worm) inositol-1 0.0039 0.0357 0.0805
Mycobacterium leprae conserved hypothetical protein 0.0036 0.031 0.0806
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0088 0.1014 0.652
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.031 0.0884
Echinococcus granulosus PHD finger protein rhinoceros 0.0034 0.0282 0.0282
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0184
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0088 0.1014 0.1014
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1527 0.8603
Echinococcus multilocularis lamin dm0 0.0026 0.0179 0.0179
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.3789 1
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0229 0.2944 1
Plasmodium vivax hypothetical protein, conserved 0.0034 0.0282 0.2371
Brugia malayi Isocitrate dehydrogenase 0.0017 0.0055 0.0098
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0357 0.0135
Brugia malayi MH2 domain containing protein 0.0127 0.1553 0.3604
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.014 0.1725 0.4005
Echinococcus granulosus inositol monophosphatase 1 0.0039 0.0357 0.0357
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0027 0.0183 0.0548
Toxoplasma gondii PHD-finger domain-containing protein 0.0034 0.0282 0.1546
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0142 0.176 1
Schistosoma mansoni jumonji domain containing protein 0.0088 0.1021 0.1021
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.1263 0.2925
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 1
Mycobacterium ulcerans lipase LipD 0.0036 0.031 0.131
Loa Loa (eye worm) hypothetical protein 0.0027 0.0183 0.0398
Echinococcus multilocularis PHD finger protein rhinoceros 0.0034 0.0282 0.0282
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.031 0.0884
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1315 1
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0039 0.0357 0.2055
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0183 0.0548
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0077 0.0076
Loa Loa (eye worm) beta-lactamase 0.0036 0.031 0.0695
Toxoplasma gondii ABC1 family protein 0.0036 0.031 0.1735
Entamoeba histolytica serine/threonine protein kinase, putative 0.011 0.1315 0.3139
Brugia malayi TAR-binding protein 0.0209 0.2665 0.6204
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.004 0.037 0.037
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0125 0.1527 0.1527
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0077 0.0076
Schistosoma mansoni lamin 0.0026 0.0179 0.0179
Loa Loa (eye worm) hypothetical protein 0.0106 0.1263 0.2925
Loa Loa (eye worm) hypothetical protein 0.0026 0.0179 0.0389
Echinococcus granulosus serine:threonine protein kinase PLK1 0.011 0.1315 0.1315
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.014 0.1725 0.4005
Loa Loa (eye worm) hypothetical protein 0.0026 0.0172 0.0373
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0088 0.1014 1
Loa Loa (eye worm) hypothetical protein 0.0088 0.1014 0.2343
Trypanosoma brucei PAB1-binding protein , putative 0.0029 0.022 0.131
Loa Loa (eye worm) hypothetical protein 0.0328 0.4288 1
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0278
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1725 0.1725
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0184
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Loa Loa (eye worm) hypothetical protein 0.002 0.0092 0.0184
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0125 0.1527 0.5094
Brugia malayi latrophilin 2 splice variant baaae 0.0072 0.0807 0.1858
Onchocerca volvulus Serine\/threonine kinase homolog 0.011 0.1315 0.2764
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0027 0.0183 0.0548
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.031 0.131
Echinococcus granulosus peregrin 0.0034 0.0282 0.0282
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Onchocerca volvulus Alhambra homolog 0.0034 0.0282 0.0251
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1725 0.1725
Onchocerca volvulus 0.0036 0.031 0.0319
Treponema pallidum fructose-bisphosphate aldolase 0.0291 0.3789 1
Brugia malayi hypothetical protein 0.0328 0.4288 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.0278 0.0278
Schistosoma mansoni lamin 0.0026 0.0179 0.0179
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0125 0.1527 1
Brugia malayi hypothetical protein 0.004 0.037 0.0836
Schistosoma mansoni inositol monophosphatase 0.0039 0.0357 0.0357
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0183 0.0548
Echinococcus multilocularis lamin 0.0026 0.0179 0.0179
Echinococcus granulosus lamin dm0 0.0026 0.0179 0.0179
Leishmania major hypothetical protein, conserved 0.0036 0.031 0.1735
Brugia malayi beta-lactamase family protein 0.0036 0.031 0.0695
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0035 0.0301 0.0852
Echinococcus granulosus tar DNA binding protein 0.0209 0.2665 0.2665
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2665 0.2665
Plasmodium falciparum phd finger protein, putative 0.0034 0.0282 0.2371
Brugia malayi hypothetical protein 0.0029 0.022 0.0484
Loa Loa (eye worm) hypothetical protein 0.0072 0.0807 0.1858
Brugia malayi beta-lactamase 0.0036 0.031 0.0695
Mycobacterium ulcerans aldehyde dehydrogenase 0.0125 0.1527 0.8603
Brugia malayi PHD-finger family protein 0.0034 0.0282 0.063
Mycobacterium ulcerans acyl-CoA synthetase 0.0027 0.0183 0.0548
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 1
Echinococcus granulosus lysine specific demethylase 5A 0.0041 0.0379 0.0379
Loa Loa (eye worm) hypothetical protein 0.0029 0.022 0.0484
Loa Loa (eye worm) transcription factor SMAD2 0.0127 0.1553 0.3604
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0057 0.0603 0.1899
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0379 0.0379
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0142 0.176 0.59
Plasmodium vivax ataxin-2 like protein, putative 0.0029 0.022 0.172
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.014 0.1725 0.1725
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.031 0.031
Loa Loa (eye worm) hypothetical protein 0.0036 0.031 0.0695
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.022 0.131
Echinococcus granulosus lamin 0.0026 0.0179 0.0179
Trypanosoma cruzi PAB1-binding protein , putative 0.0029 0.022 0.131
Trichomonas vaginalis inositol monophosphatase, putative 0.0039 0.0357 0.0135
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0561 0.072
Loa Loa (eye worm) hypothetical protein 0.0034 0.0278 0.0619
Echinococcus multilocularis inositol monophosphatase 1 0.0039 0.0357 0.0357
Brugia malayi AMP-binding enzyme family protein 0.0027 0.0183 0.0398
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0039 0.0357 0.0135
Brugia malayi jmjC domain containing protein 0.0111 0.1331 0.3084
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0278
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0088 0.1014 0.1014
Trypanosoma cruzi polo-like protein kinase, putative 0.011 0.1315 1
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0055
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.022 0.172
Brugia malayi Probable ClpP-like protease 0.0088 0.1014 0.2343
Loa Loa (eye worm) jmjC domain-containing protein 0.007 0.0773 0.1778
Brugia malayi jmjC domain containing protein 0.0041 0.0379 0.0857
Brugia malayi isocitrate dehydrogenase 0.0017 0.0055 0.0098
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0209 0.2665 0.6204
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0357 0.24
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.0278 0.0278
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.011 0.1315 0.3046
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1725 0.1725
Schistosoma mansoni tar DNA-binding protein 0.0209 0.2665 0.2665
Toxoplasma gondii LsmAD domain-containing protein 0.0029 0.022 0.1121
Plasmodium falciparum ataxin-2 like protein, putative 0.0029 0.022 0.172
Mycobacterium ulcerans hypothetical protein 0.0027 0.0183 0.0548
Brugia malayi Intermediate filament tail domain containing protein 0.0026 0.0179 0.0389
Mycobacterium tuberculosis Conserved protein 0.0036 0.031 0.0884
Schistosoma mansoni hypothetical protein 0.0034 0.0278 0.0278
Schistosoma mansoni inositol monophosphatase 0.0039 0.0357 0.0357
Loa Loa (eye worm) PHD-finger family protein 0.0034 0.0282 0.063
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.031 0.0884
Trypanosoma brucei polo-like protein kinase 0.011 0.1315 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0127 0.1553 0.3604
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0027 0.0183 0.0444
Giardia lamblia Kinase, PLK 0.011 0.1315 0.2944
Schistosoma mansoni hypothetical protein 0.0747 1 1
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0034 0.0282 0.0282
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1527 0.1527
Schistosoma mansoni hypothetical protein 0.0034 0.0282 0.0282
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 0.5532
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0017 0.0055 0.0055
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.011 0.1315 0.8561
Entamoeba histolytica hypothetical protein 0.004 0.037 0.0519
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.031 0.0884
Schistosoma mansoni aldehyde dehydrogenase 0.0125 0.1527 0.1527
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0125 0.1527 0.1527
Schistosoma mansoni hypothetical protein 0.0072 0.0807 0.0807
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.0278 0.0278
Schistosoma mansoni jumonji/arid domain-containing protein 0.0041 0.0379 0.0379
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.0278 0.0619
Schistosoma mansoni peptidase Clp (S14 family) 0.0088 0.1014 0.1014
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0039 0.0357 0.1593
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0027 0.0183 0.0548
Schistosoma mansoni kinase 0.0056 0.058 0.058
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 0.2199
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.002 0.0092 0.0127
Brugia malayi beta-lactamase family protein 0.0036 0.031 0.0695
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.031 0.2026
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0291 0.3789 1
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0088 0.1014 1
Brugia malayi Bromodomain containing protein 0.0034 0.0282 0.063
Echinococcus multilocularis isocitrate dehydrogenase 0.0017 0.0055 0.0055
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.031 0.031
Mycobacterium tuberculosis Conserved protein 0.0036 0.031 0.0884
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0019 0.0077 0.0076
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0039 0.0357 0.24
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.014 0.1725 0.1725
Toxoplasma gondii hypothetical protein 0.003 0.0232 0.1206
Schistosoma mansoni serine/threonine protein kinase 0.011 0.1315 0.1315
Trichomonas vaginalis CAMK family protein kinase 0.011 0.1315 0.2888
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0088 0.1014 0.5273
Leishmania major hypothetical protein, conserved 0.0029 0.022 0.1121
Leishmania major 4-coumarate:coa ligase-like protein 0.0027 0.0183 0.0871
Plasmodium vivax acyl-CoA synthetase, putative 0.002 0.0092 0.0383
Brugia malayi intermediate filament protein 0.0026 0.0179 0.0389
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.014 0.1725 0.1725
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0291 0.3789 1

Activities

Activity type Activity value Assay description Source Reference
MIC (functional) Antifungal activity against Cryptococcus neoformans ATCC 32264 after 48 hrs by broth microdilution technique ChEMBL. 18752959
MIC (functional) Antifungal activity against Saccharomyces cerevisiae ATCC 9763 after 48 hrs by broth microdilution technique ChEMBL. 18752959
MIC (functional) Antifungal activity against Candida albicans ATCC 10231 after 48 hrs by broth microdilution technique ChEMBL. 18752959

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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