Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.051 | 0.55 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.002 | 0.0928 | 0.0207 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4 | 0.4128 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Schistosoma mansoni | gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 | 0.0152 | 0.969 | 1 |
Loa Loa (eye worm) | acetyltransferase | 0.0152 | 0.969 | 0.969 |
Echinococcus multilocularis | gcn5proteinral control of amino acid synthesis | 0.0152 | 0.969 | 0.966 |
Brugia malayi | acetyltransferase, GNAT family protein | 0.0152 | 0.969 | 0.969 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.002 | 0.0928 | 1 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.002 | 0.0928 | 0.0958 |
Entamoeba histolytica | acetyltransferase, GNAT family | 0.0041 | 0.2307 | 1 |
Echinococcus granulosus | dna polymerase kappa | 0.002 | 0.0928 | 0.0038 |
Schistosoma mansoni | DNA polymerase eta | 0.002 | 0.0928 | 0.0958 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0894 | 0.963 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.002 | 0.0928 | 1 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0894 | 0.3499 |
Brugia malayi | TAR-binding protein | 0.0067 | 0.4 | 0.4 |
Trypanosoma brucei | unspecified product | 0.002 | 0.0928 | 1 |
Echinococcus granulosus | dna polymerase eta | 0.002 | 0.0928 | 0.0038 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4 | 0.4128 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4 | 0.4128 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.002 | 0.0928 | 1 |
Brugia malayi | RNA binding protein | 0.0067 | 0.4 | 0.4 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.002 | 0.0894 | 0.5 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Echinococcus granulosus | muscleblind protein | 0.0157 | 1 | 1 |
Echinococcus multilocularis | dna polymerase kappa | 0.002 | 0.0928 | 0.0038 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4 | 0.4128 |
Giardia lamblia | DINP protein human, muc B family | 0.002 | 0.0928 | 0.4023 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0928 | 1 |
Giardia lamblia | Histone acetyltransferase GCN5 | 0.0041 | 0.2307 | 1 |
Trichomonas vaginalis | bromodomain-containing protein, putative | 0.0045 | 0.2555 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0928 | 0.0928 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.051 | 0.55 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | unspecified product | 0.0014 | 0.051 | 0.55 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0157 | 1 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.002 | 0.0894 | 0.963 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.002 | 0.0928 | 0.0958 |
Loa Loa (eye worm) | hypothetical protein | 0.002 | 0.0928 | 0.0928 |
Mycobacterium ulcerans | DNA polymerase IV | 0.002 | 0.0928 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.002 | 0.0894 | 0.3874 |
Loa Loa (eye worm) | hypothetical protein | 0.0157 | 1 | 1 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.002 | 0.0928 | 0.0243 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.002 | 0.0894 | 0.0894 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0067 | 0.4 | 0.4128 |
Loa Loa (eye worm) | TAR-binding protein | 0.0067 | 0.4 | 0.4 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0067 | 0.4 | 0.4 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-B | 0.0045 | 0.2555 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0894 | 0.0922 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0148 | 0.9407 | 0.9349 |
Echinococcus multilocularis | muscleblind protein | 0.0157 | 1 | 1 |
Schistosoma mansoni | ap endonuclease | 0.002 | 0.0894 | 0.0922 |
Trichomonas vaginalis | cat eye syndrome critical region protein 2, cscr2, putative | 0.0045 | 0.2555 | 1 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.002 | 0.0928 | 0.0207 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.002 | 0.0894 | 0.5 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.002 | 0.0894 | 0.963 |
Echinococcus granulosus | histone acetyltransferase KAT2B | 0.0045 | 0.2555 | 0.1824 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.002 | 0.0928 | 1 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0928 | 0.0038 |
Leishmania major | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Toxoplasma gondii | exonuclease III APE | 0.002 | 0.0894 | 0.3499 |
Echinococcus multilocularis | tar DNA binding protein | 0.0067 | 0.4 | 0.3411 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.002 | 0.0928 | 0.0928 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.002 | 0.0894 | 0.963 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.051 | 0.55 |
Toxoplasma gondii | histone lysine acetyltransferase GCN5-A | 0.0045 | 0.2555 | 1 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0067 | 0.4 | 0.4 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.002 | 0.0928 | 1 |
Plasmodium vivax | histone acetyltransferase GCN5, putative | 0.0045 | 0.2555 | 1 |
Echinococcus multilocularis | dna polymerase eta | 0.002 | 0.0928 | 0.0038 |
Leishmania major | DNA polymerase eta, putative | 0.002 | 0.0928 | 1 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.002 | 0.0928 | 0.0928 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.002 | 0.0928 | 0.0038 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0014 | 0.051 | 0.55 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.002 | 0.0894 | 0.3874 |
Plasmodium falciparum | histone acetyltransferase GCN5 | 0.0041 | 0.2307 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.002 | 0.0894 | 0.963 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0067 | 0.4 | 0.4 |
Echinococcus granulosus | tar DNA binding protein | 0.0067 | 0.4 | 0.3411 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.002 | 0.0894 | 0.0894 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 169.9 uM | Inhibition of pig kidney microsomal Aminopeptidase N | ChEMBL. | 19423354 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.