Detailed information for compound 1001864

Basic information

Technical information
  • TDR Targets ID: 1001864
  • Name: 6-bromo-1H-indazol-3-amine
  • MW: 212.047 | Formula: C7H6BrN3
  • H donors: 2 H acceptors: 1 LogP: 1.9 Rotable bonds: 0
    Rule of 5 violations (Lipinski): 1
  • SMILES: Brc1ccc2c(c1)[nH]nc2N
  • InChi: 1S/C7H6BrN3/c8-4-1-2-5-6(3-4)10-11-7(5)9/h1-3H,(H3,9,10,11)
  • InChiKey: WLDHNAMVDBASAW-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (6-bromo-1H-indazol-3-yl)amine
  • 404827-77-6
  • ZINC03883310
  • ST5401062

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0123 0.1415 0.2155
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0577 0.0878
Loa Loa (eye worm) RNA binding protein 0.0133 0.166 0.166
Brugia malayi Bromodomain containing protein 0.0076 0.0327 0.03
Plasmodium vivax hypothetical protein, conserved 0.0063 0.0028 0.5
Trypanosoma brucei ISWI complex protein 0.0083 0.0499 0.5
Leishmania major hypothetical protein, conserved 0.0083 0.0499 0.5
Schistosoma mansoni hypothetical protein 0.0112 0.1173 0.1788
Brugia malayi hypothetical protein 0.0235 0.4033 0.4017
Loa Loa (eye worm) PHD-finger family protein 0.0112 0.1173 0.1173
Brugia malayi Bromodomain containing protein 0.0408 0.8044 0.8038
Brugia malayi RNA binding protein 0.0133 0.166 0.1637
Loa Loa (eye worm) bromodomain containing protein 0.0096 0.0798 0.0798
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0324 0.611 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.166 0.2529
Brugia malayi jmjC domain containing protein 0.0086 0.0577 0.0551
Echinococcus multilocularis jumonji domain containing protein 0.0088 0.06 0.0982
Schistosoma mansoni zinc finger protein 0.0083 0.0499 0.076
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0063 0.0028 0.0042
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0195 0.3107 0.5084
Echinococcus multilocularis tar DNA binding protein 0.0133 0.166 0.2716
Brugia malayi MH2 domain containing protein 0.0126 0.1491 0.1467
Echinococcus granulosus lysine specific demethylase 5A 0.0086 0.0577 0.0903
Echinococcus granulosus tar DNA binding protein 0.0133 0.166 0.2683
Loa Loa (eye worm) MH2 domain-containing protein 0.0126 0.1491 0.1491
Schistosoma mansoni zinc finger protein 0.0106 0.104 0.1584
Giardia lamblia PHD finger protein 15 0.0063 0.0028 0.5
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0093 0.0721 0.118
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0206 0.3354 0.5488
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0721 0.1098
Loa Loa (eye worm) jmjC domain-containing protein 0.013 0.1584 0.1584
Loa Loa (eye worm) hypothetical protein 0.0492 1 1
Plasmodium falciparum phd finger protein, putative 0.0063 0.0028 0.5
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0195 0.3107 0.5062
Echinococcus multilocularis lysine specific demethylase 5A 0.0076 0.0335 0.0548
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0324 0.611 1
Schistosoma mansoni tar DNA-binding protein 0.0133 0.166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0235 0.4033 0.4033
Brugia malayi PHD-finger family protein 0.0135 0.1714 0.1691
Schistosoma mansoni tar DNA-binding protein 0.0133 0.166 0.2529
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0093 0.0721 0.1098
Echinococcus multilocularis peregrin 0.0076 0.0327 0.0535
Echinococcus granulosus zinc finger protein 0.0106 0.104 0.1664
Loa Loa (eye worm) PHD-finger family protein 0.0063 0.0028 0.0028
Schistosoma mansoni bromodomain containing protein 0.0344 0.6563 1
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0093 0.0721 0.118
Schistosoma mansoni methyl-cpg binding protein mbd 0.0093 0.0721 0.1098
Loa Loa (eye worm) hypothetical protein 0.0221 0.3714 0.3714
Onchocerca volvulus 0.0492 1 1
Echinococcus granulosus histone lysine methyltransferase setb 0.0093 0.0721 0.114
Loa Loa (eye worm) hypothetical protein 0.0209 0.3415 0.3415
Echinococcus multilocularis zinc finger protein 0.0106 0.104 0.1701
Schistosoma mansoni jumonji/arid domain-containing protein 0.0086 0.0577 0.0878
Loa Loa (eye worm) hypothetical protein 0.0063 0.0028 0.0028
Brugia malayi TAR-binding protein 0.0133 0.166 0.1637
Brugia malayi jmjC domain containing protein 0.0206 0.3354 0.3335
Loa Loa (eye worm) TAR-binding protein 0.0133 0.166 0.166
Schistosoma mansoni hypothetical protein 0.0063 0.0028 0.0042
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0133 0.166 0.166
Schistosoma mansoni tar DNA-binding protein 0.0133 0.166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0384 0.7503 0.7503
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0206 0.3354 0.5468
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0123 0.1415 0.2315
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.4033 0.6585
Brugia malayi RNA recognition motif domain containing protein 0.0133 0.166 0.1637
Schistosoma mansoni tar DNA-binding protein 0.0133 0.166 0.2529
Loa Loa (eye worm) hypothetical protein 0.0108 0.1072 0.1072
Echinococcus granulosus methyl CpG binding domain protein 2 0.0093 0.0721 0.114
Loa Loa (eye worm) hypothetical protein 0.0093 0.0721 0.0721
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0028 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0086 0.0577 0.0577
Echinococcus multilocularis PHD finger protein rhinoceros 0.0063 0.0028 0.0045
Loa Loa (eye worm) hypothetical protein 0.0232 0.3955 0.3955
Brugia malayi Bromodomain containing protein 0.0208 0.3406 0.3387
Schistosoma mansoni jumonji domain containing protein 0.0164 0.237 0.3611
Toxoplasma gondii PHD-finger domain-containing protein 0.0063 0.0028 0.5
Echinococcus granulosus fetal alzheimer antigen falz 0.0123 0.1415 0.228
Trypanosoma cruzi ISWI complex protein 0.0083 0.0499 0.5
Echinococcus granulosus peregrin 0.0076 0.0327 0.0492
Trypanosoma cruzi ISWI complex protein 0.0083 0.0499 0.5
Loa Loa (eye worm) hypothetical protein 0.0492 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.4033 0.6601
Loa Loa (eye worm) transcription factor SMAD2 0.0126 0.1491 0.1491
Echinococcus granulosus jumonji domain containing protein 0.0088 0.06 0.0941
Schistosoma mansoni hypothetical protein 0.0083 0.0499 0.076
Schistosoma mansoni methyl-cpg binding protein mbd 0.0093 0.0721 0.1098

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 131 uM Inhibition of JAK2 ChEMBL. 19019674

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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