Detailed information for compound 1001917

Basic information

Technical information
  • TDR Targets ID: 1001917
  • Name: (2S)-2-amino-N-[4-(phenylmethoxy)phenyl]propa namide
  • MW: 270.326 | Formula: C16H18N2O2
  • H donors: 2 H acceptors: 1 LogP: 2.06 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: C[C@@H](C(=O)Nc1ccc(cc1)OCc1ccccc1)N
  • InChi: 1S/C16H18N2O2/c1-12(17)16(19)18-14-7-9-15(10-8-14)20-11-13-5-3-2-4-6-13/h2-10,12H,11,17H2,1H3,(H,18,19)/t12-/m0/s1
  • InChiKey: OBPWVVSCTGDYDK-LBPRGKRZSA-N  


Substructure search Similarity search

Network

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Synonyms

  • (2S)-2-amino-N-[4-(benzyloxy)phenyl]propionamide

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens leukotriene A4 hydrolase Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
Loa Loa (eye worm) leukotriene A4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma japonicum ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative Get druggable targets OG5_129538 All targets in OG5_129538
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) Get druggable targets OG5_129538 All targets in OG5_129538
Echinococcus granulosus leukotriene A 4 hydrolase Get druggable targets OG5_129538 All targets in OG5_129538
Candida albicans leukotriene A4 hydrolase/leucyl aminopeptidase Get druggable targets OG5_129538 All targets in OG5_129538
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 leukotriene A4 hydrolase 611 aa 508 aa 22.8 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Treponema pallidum bacterioferrin (TpF1) 0.0009 0 0.5
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Schistosoma mansoni ran 0.0021 0.0267 0.0313
Onchocerca volvulus Glucosylceramidase homolog 0.0172 0.3424 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.057 0.1239
Brugia malayi CXXC zinc finger family protein 0.0029 0.0432 0.0424
Schistosoma mansoni hypothetical protein 0.0016 0.0148 0.0174
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Entamoeba histolytica hypothetical protein 0.0038 0.0615 1
Onchocerca volvulus 0.0015 0.0132 0.0057
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0021 0.0267 0.5
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0102
Schistosoma mansoni cpg binding protein 0.0031 0.0467 0.0549
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0049 0.0853 0.0846
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0527 0.0519
Echinococcus granulosus snurportin 1 0.0308 0.6273 0.6273
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.0794 0.0784
Mycobacterium ulcerans beta-lactamase 0.0036 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0102
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0102
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Mycobacterium leprae conserved hypothetical protein 0.0036 0.057 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0009 0 0.5
Loa Loa (eye worm) hypothetical protein 0.0016 0.0148 0.0138
Schistosoma mansoni hypothetical protein 0.0416 0.8516 1
Echinococcus multilocularis aminopeptidase N 0.0015 0.0132 0.0132
Echinococcus granulosus leukotriene A 4 hydrolase 0.0279 0.5654 0.5654
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.057 0.1239
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0121
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0121
Schistosoma mansoni egf-like domain protein 0.0014 0.0113 0.0133
Brugia malayi Calcium binding EGF domain containing protein 0.0014 0.0113 0.0105
Schistosoma mansoni hypothetical protein 0.0338 0.6884 0.8084
Plasmodium vivax importin-beta 2, putative 0.0029 0.0426 0.6722
Brugia malayi hypothetical protein 0.0015 0.0132 0.0124
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0017 0.0185 0.0218
Schistosoma mansoni transcription factor LCR-F1 0.0038 0.0615 0.0722
Loa Loa (eye worm) hypothetical protein 0.0049 0.0853 0.0843
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.057 0.1239
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.057 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.057 0.057
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.057 0.0669
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.057 0.1073
Brugia malayi beta-lactamase 0.0036 0.057 0.0562
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Toxoplasma gondii aminopeptidase n, putative 0.0015 0.0132 0.0217
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0021 0.0267 0.308
Schistosoma mansoni cpg binding protein 0.0029 0.0432 0.0508
Entamoeba histolytica hypothetical protein 0.0038 0.0615 1
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Loa Loa (eye worm) latrophilin receptor protein 2 0.0016 0.0148 0.0138
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0279 0.5654 0.6639
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Toxoplasma gondii ABC1 family protein 0.0036 0.057 0.5278
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0016 0.0148 0.014
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Brugia malayi Importin beta-1 subunit 0.0029 0.0426 0.0418
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0132 0.0124
Echinococcus multilocularis fibrillin 1 0.0014 0.0113 0.0113
Trypanosoma cruzi importin beta-1 subunit, putative 0.0023 0.0312 0.4113
Mycobacterium tuberculosis Conserved protein 0.0036 0.057 0.1239
Mycobacterium ulcerans hypothetical protein 0.0036 0.057 1
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0021 0.0267 0.308
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Brugia malayi TATA binding protein associated factor 0.0015 0.0132 0.0124
Echinococcus granulosus survival motor neuron protein 1 0.0487 1 1
Entamoeba histolytica hypothetical protein 0.0038 0.0615 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0132 0.0248
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.057 0.1073
Mycobacterium leprae Probable lipase LipE 0.0036 0.057 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.3617 0.6811
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0021 0.0267 0.0256
Onchocerca volvulus 0.0099 0.1898 0.5392
Mycobacterium ulcerans aminopeptidase N PepN 0.0015 0.0132 0.2312
Echinococcus granulosus aminopeptidase N 0.0015 0.0132 0.0132
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.057 0.1239
Brugia malayi hypothetical protein 0.0015 0.0132 0.0124
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0308 0.6273 0.6269
Toxoplasma gondii aminopeptidase N, putative 0.0015 0.0132 0.0217
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Loa Loa (eye worm) TATA binding protein associated factor 0.0015 0.0132 0.0121
Loa Loa (eye worm) bone morphogenetic protein 1b 0.0014 0.0113 0.0102
Echinococcus granulosus GTP binding nuclear protein Ran 0.0021 0.0267 0.0267
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0794 0.0794
Echinococcus granulosus Tolloid protein 1 0.0014 0.0113 0.0113
Schistosoma mansoni hypothetical protein 0.0016 0.0148 0.0174
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.057 0.057
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0262 0.5311 0.5306
Toxoplasma gondii HEAT repeat-containing protein 0.0029 0.0426 0.362
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0132 0.0124
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0794 0.0794
Leishmania major GTP-binding protein, putative 0.0021 0.0267 0.308
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0015 0.0132 0.0155
Echinococcus granulosus importin subunit beta 1 0.0029 0.0426 0.0426
Brugia malayi Fibulin-1 precursor 0.0014 0.0113 0.0105
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0038 0.0615 0.0615
Schistosoma mansoni hypothetical protein 0.0016 0.0148 0.0174
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.057 0.1073
Brugia malayi hypothetical protein 0.0128 0.2503 0.2497
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.057 0.056
Echinococcus multilocularis geminin 0.0338 0.6884 0.6884
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0279 0.5654 0.5654
Echinococcus multilocularis cpg binding protein 0.0031 0.0467 0.0467
Loa Loa (eye worm) hypothetical protein 0.0487 1 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0794 0.0933
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.057 0.1239
Toxoplasma gondii aminopeptidase N protein 0.0015 0.0132 0.0217
Echinococcus multilocularis importin subunit beta 1 0.0029 0.0426 0.0426
Echinococcus multilocularis Tolloid protein 1 0.0014 0.0113 0.0113
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0312 0.0587
Echinococcus multilocularis survival motor neuron protein 1 0.0487 1 1
Echinococcus granulosus GPCR family 2 0.0016 0.0148 0.0148
Plasmodium vivax hypothetical protein, conserved 0.0036 0.057 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0527 0.0517
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0011
Schistosoma mansoni hypothetical protein 0.0308 0.6273 0.7366
Echinococcus multilocularis laminin 0.0014 0.0113 0.0113
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0132 0.0248
Entamoeba histolytica hypothetical protein 0.0023 0.0312 0.3732
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0021 0.0267 0.4582
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.057 0.0562
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0794 0.0933
Entamoeba histolytica hypothetical protein 0.0038 0.0615 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.0794 0.0794
Brugia malayi Peptidase family M1 containing protein 0.0015 0.0132 0.0124
Leishmania major hypothetical protein, conserved 0.0036 0.057 1
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Brugia malayi beta-lactamase family protein 0.0036 0.057 0.0562
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.057 1
Trichomonas vaginalis glucosylceramidase, putative 0.0181 0.3617 0.6811
Plasmodium falciparum importin beta, putative 0.0029 0.0426 1
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0021 0.0267 0.1776
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0038 0.0615 0.0615
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.057 0.1073
Schistosoma mansoni importin beta-1 0.0029 0.0426 0.05
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0426 0.6722
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.057 0.1073
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0102
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0099 0.1898 0.1891
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0049 0.0853 0.0843
Toxoplasma gondii histone lysine methyltransferase SET1 0.0055 0.0978 1
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0015 0.0132 0.0248
Mycobacterium ulcerans lipase LipD 0.0036 0.057 1
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0016 0.0148 0.0148
Brugia malayi Calcitonin receptor-like protein seb-1 0.0049 0.0853 0.0846
Brugia malayi hypothetical protein 0.0038 0.0615 0.0607
Loa Loa (eye worm) hypothetical protein 0.0014 0.0113 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.0794 0.0794
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0267 0.308
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Echinococcus multilocularis snurportin 1 0.0308 0.6273 0.6273
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0021 0.0267 0.0259
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0432 0.0422
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.057 0.0669
Brugia malayi Latrophilin receptor protein 2 0.0016 0.0148 0.014
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Onchocerca volvulus 0.0029 0.0432 0.0965
Onchocerca volvulus 0.0036 0.057 0.138
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0016 0.0148 0.0148
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.057 0.1239
Onchocerca volvulus 0.0015 0.0132 0.0057
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Trichomonas vaginalis ran, putative 0.0021 0.0267 0.0502
Loa Loa (eye worm) aminopeptidase N 0.0015 0.0132 0.0121
Entamoeba histolytica Ran family GTPase 0.0021 0.0267 0.2794
Loa Loa (eye worm) multiple epidermal growth factor-like domains 6 0.0014 0.0113 0.0102
Loa Loa (eye worm) hypothetical protein 0.0015 0.0132 0.0121
Schistosoma mansoni hypothetical protein 0.0338 0.6884 0.8084
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0015 0.0132 0.0132
Onchocerca volvulus 0.0036 0.057 0.138
Loa Loa (eye worm) beta-lactamase 0.0036 0.057 0.056
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0021 0.0267 0.0267
Echinococcus multilocularis dnaJ subfamily B 0.0416 0.8516 0.8516
Schistosoma mansoni hypothetical protein 0.0038 0.0615 0.0722
Mycobacterium tuberculosis Conserved protein 0.0036 0.057 0.1239
Trichomonas vaginalis glucosylceramidase, putative 0.0262 0.5311 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.0794 0.0786
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.057 1
Echinococcus granulosus geminin 0.0338 0.6884 0.6884
Schistosoma mansoni hypothetical protein 0.0099 0.1898 0.2229
Loa Loa (eye worm) hypothetical protein 0.0029 0.0426 0.0416
Echinococcus multilocularis GPCR, family 2 0.0016 0.0148 0.0148
Echinococcus granulosus cpg binding protein 0.0031 0.0467 0.0467
Mycobacterium tuberculosis Conserved protein 0.0036 0.057 0.1239
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0015 0.0132 0.0155
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.46 1
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Trichomonas vaginalis glucosylceramidase, putative 0.0172 0.3424 0.6446
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0016 0.0148 0.0148
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0021 0.0267 0.308
Schistosoma mansoni hypothetical protein 0.0034 0.0527 0.0619
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0279 0.5654 0.5649
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0015 0.0132 0.0132
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.0794 0.0933
Mycobacterium ulcerans aminopeptidase N PepN 0.0015 0.0132 0.2312
Trichomonas vaginalis esterase, putative 0.0036 0.057 0.1073
Schistosoma mansoni hypothetical protein 0.0016 0.0148 0.0174
Onchocerca volvulus 0.0036 0.057 0.138
Leishmania major importin beta-1 subunit, putative 0.0023 0.0312 0.4113
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0009 0.0011 0.0011
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.057 0.1239
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0262 0.5311 0.5307
Echinococcus granulosus laminin 0.0014 0.0113 0.0113
Schistosoma mansoni subfamily M12A unassigned peptidase (M12 family) 0.0014 0.0113 0.0133
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Schistosoma mansoni aminopeptidase A (M01 family) 0.0015 0.0132 0.0155
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0016 0.0148 0.0148
Schistosoma mansoni survival motor neuron protein 0.0099 0.1898 0.2229
Schistosoma mansoni cpg binding protein 0.0031 0.0467 0.0549
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1117 0.1311
Onchocerca volvulus 0.0015 0.0132 0.0057
Brugia malayi beta-lactamase family protein 0.0036 0.057 0.0562
Trypanosoma brucei importin beta-1 subunit, putative 0.0029 0.0426 0.6722
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.057 1
Brugia malayi RNA, U transporter 1 0.0082 0.154 0.1533
Loa Loa (eye worm) hypothetical protein 0.0036 0.057 0.056
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0023 0.0312 0.0587
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.057 1
Schistosoma mansoni ran 0.0021 0.0267 0.0313
Brugia malayi Low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0113 0.0105
Trichomonas vaginalis importin beta-1, putative 0.0023 0.0312 0.0587
Loa Loa (eye worm) peptidase family M1 containing protein 0.0015 0.0132 0.0121
Echinococcus granulosus dnaJ subfamily B 0.0416 0.8516 0.8516
Loa Loa (eye worm) low-density lipoprotein receptor repeat class B containing protein 0.0014 0.0113 0.0102

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 150 nM Inhibition of human recombinant LTA4-h by peptidase assay ChEMBL. 18394906
IC50 (functional) > 10000 nM Inhibition of calcium ionophore-induced LTB4 synthesis in human whole blood after 15 mins by ELISA ChEMBL. 18394906

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 18394906

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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