Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Onchocerca volvulus | Polycomb protein Sfmbt homolog | 0.0046 | 0.1119 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0257 | 0.9059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.9059 | 0.9005 |
Loa Loa (eye worm) | RNA binding protein | 0.0257 | 0.9059 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.9059 | 0.9005 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0546 | 0.0603 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.9059 | 0.9005 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2044 | 0.176 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0679 | 0.0749 |
Echinococcus granulosus | endonuclease exonuclease phosphatase | 0.0183 | 0.6261 | 0.6713 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0679 | 0.014 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0041 | 0.0918 | 0.0437 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.1361 | 0.1502 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0257 | 0.9059 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.1285 | 0.1418 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1119 | 0.1235 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0875 | 0.5 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0875 | 0.5 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0875 | 0.0386 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0042 | 0.0939 | 0.0416 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0875 | 0.5 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0875 | 0.5 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0875 | 0.5 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0875 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0138 | 0.4576 | 0.5051 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.0524 | 0.0579 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0875 | 0.0965 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2044 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0143 | 0.4761 | 0.5255 |
Brugia malayi | C2-HC type zinc finger protein C.e-MyT1 | 0.0053 | 0.1361 | 0.1502 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0071 | 0.2044 | 1 |
Mycobacterium leprae | conserved hypothetical protein | 0.004 | 0.0875 | 0.5 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0041 | 0.0918 | 0.0437 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.9059 | 0.9005 |
Brugia malayi | hypothetical protein | 0.0042 | 0.0939 | 0.1036 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1119 | 0.0606 |
Brugia malayi | intermediate filament protein | 0.0031 | 0.0546 | 0.0603 |
Echinococcus multilocularis | geminin | 0.0192 | 0.6621 | 0.7136 |
Schistosoma mansoni | sex comb on midleg homolog | 0.0046 | 0.1119 | 0.0606 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.4761 | 0.4458 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.6621 | 0.6426 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0875 | 0.0348 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0031 | 0.0546 | 0.0603 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Brugia malayi | beta-lactamase | 0.004 | 0.0875 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0679 | 0.0749 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0875 | 0.5 |
Onchocerca volvulus | 0.004 | 0.0875 | 0.574 | |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0138 | 0.4576 | 0.5051 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0143 | 0.4761 | 0.5255 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0875 | 0.5 |
Schistosoma mansoni | hypothetical protein | 0.0042 | 0.0939 | 0.0416 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0875 | 0.0386 |
Echinococcus multilocularis | tar DNA binding protein | 0.0257 | 0.9059 | 1 |
Brugia malayi | mbt repeat family protein | 0.0046 | 0.1119 | 0.1235 |
Echinococcus multilocularis | histone acetyltransferase MYST2 | 0.0053 | 0.1361 | 0.0957 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.1285 | 0.1418 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0875 | 0.0348 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0071 | 0.2044 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1119 | 0.1235 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.1285 | 0.1418 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0875 | 0.5 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2044 | 1 |
Echinococcus granulosus | polycomb protein SCMH1 | 0.0046 | 0.1119 | 0.0673 |
Brugia malayi | TAR-binding protein | 0.0257 | 0.9059 | 1 |
Onchocerca volvulus | 0.004 | 0.0875 | 0.574 | |
Echinococcus granulosus | suppression of tumorigenicity 18 protein | 0.0053 | 0.1361 | 0.0957 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0875 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0071 | 0.2044 | 0.176 |
Loa Loa (eye worm) | mbt repeat family protein | 0.0046 | 0.1119 | 0.1235 |
Echinococcus granulosus | histone acetyltransferase MYST2 | 0.0053 | 0.1361 | 0.0957 |
Schistosoma mansoni | tar DNA-binding protein | 0.0257 | 0.9059 | 0.9005 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0875 | 0.0965 |
Loa Loa (eye worm) | TAR-binding protein | 0.0257 | 0.9059 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.4761 | 0.4458 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0875 | 0.0965 |
Echinococcus granulosus | tar DNA binding protein | 0.0257 | 0.9059 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0143 | 0.4761 | 0.4458 |
Mycobacterium tuberculosis | Possible penicillin-binding protein | 0.0255 | 0.8983 | 1 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0031 | 0.0546 | 0.0603 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0875 | 0.5 |
Mycobacterium leprae | Probable lipase LipE | 0.004 | 0.0875 | 0.5 |
Echinococcus granulosus | SAM and MBT domain containing protein | 0.0046 | 0.1119 | 0.0673 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 0.6621 | 0.6426 |
Onchocerca volvulus | 0.004 | 0.0875 | 0.574 | |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.4761 | 0.4951 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0071 | 0.2044 | 1 |
Echinococcus multilocularis | SAM and MBT domain containing protein | 0.0046 | 0.1119 | 0.0673 |
Schistosoma mansoni | scm-relatedprotein containing 4 mbt domains (sfmbt) | 0.0046 | 0.1119 | 0.0606 |
Echinococcus granulosus | geminin | 0.0192 | 0.6621 | 0.7136 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0042 | 0.0939 | 0.0461 |
Loa Loa (eye worm) | MBCTL1 | 0.0053 | 0.1361 | 0.1502 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0875 | 0.0965 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0875 | 0.0965 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0042 | 0.0939 | 0.0461 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.4761 | 0.4951 |
Echinococcus multilocularis | polycomb protein SCMH1 | 0.0046 | 0.1119 | 0.0673 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0143 | 0.4761 | 0.4951 |
Loa Loa (eye worm) | intermediate filament protein | 0.0031 | 0.0546 | 0.0603 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0875 | 0.5 |
Echinococcus multilocularis | endonuclease exonuclease phosphatase | 0.0183 | 0.6261 | 0.6713 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2044 | 0.1585 |
Onchocerca volvulus | 0.0046 | 0.1119 | 1 | |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.1285 | 0.1418 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0143 | 0.4761 | 0.4951 |
Echinococcus multilocularis | suppression of tumorigenicity 18 protein | 0.0053 | 0.1361 | 0.0957 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0138 | 0.4576 | 0.5051 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0071 | 0.2044 | 0.2256 |
Brugia malayi | RNA binding protein | 0.0257 | 0.9059 | 1 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0875 | 0.5 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0071 | 0.2044 | 0.2256 |
Schistosoma mansoni | myelin transcription factor 1 myt1 | 0.0053 | 0.1361 | 0.0862 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0875 | 0.0965 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.