Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | TAR-binding protein | 0.0072 | 0.292 | 0.7673 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1746 | 0.1746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1746 | 0.1746 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.292 | 0.292 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.292 | 0.292 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1091 | 0.1091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1746 | 0.1746 |
Schistosoma mansoni | hypothetical protein | 0.0023 | 0.0071 | 0.0071 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0041 | 0.1091 | 0.1091 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1746 | 0.1746 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0026 | 0.0198 | 0.0198 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2677 | 0.2677 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Brugia malayi | RNA binding protein | 0.0072 | 0.292 | 0.7673 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.292 | 0.292 |
Loa Loa (eye worm) | hypothetical protein | 0.0043 | 0.1254 | 0.3541 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0052 | 0.1746 | 0.5013 |
Loa Loa (eye worm) | hypothetical protein | 0.0048 | 0.1539 | 0.4395 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0052 | 0.1746 | 0.1746 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0052 | 0.1746 | 0.1746 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0068 | 0.2677 | 0.2677 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0026 | 0.0198 | 0.0198 |
Loa Loa (eye worm) | hypothetical protein | 0.008 | 0.3413 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0192 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.292 | 0.292 |
Echinococcus multilocularis | tar DNA binding protein | 0.0072 | 0.292 | 0.292 |
Schistosoma mansoni | bromodomain containing protein | 0.0072 | 0.2916 | 0.2916 |
Loa Loa (eye worm) | RNA binding protein | 0.0072 | 0.292 | 0.8527 |
Brugia malayi | Bromodomain containing protein | 0.0085 | 0.3698 | 1 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0026 | 0.0198 | 0.0198 |
Echinococcus granulosus | tar DNA binding protein | 0.0072 | 0.292 | 0.292 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0052 | 0.1746 | 0.4159 |
Schistosoma mansoni | tar DNA-binding protein | 0.0072 | 0.292 | 0.292 |
Loa Loa (eye worm) | hypothetical protein | 0.0046 | 0.1412 | 0.4014 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0072 | 0.292 | 0.7673 |
Brugia malayi | Bromodomain containing protein | 0.0043 | 0.1249 | 0.2673 |
Loa Loa (eye worm) | TAR-binding protein | 0.0072 | 0.292 | 0.8527 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0052 | 0.1746 | 0.1746 |
Echinococcus multilocularis | geminin | 0.0192 | 1 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0072 | 0.292 | 0.8527 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (functional) | = 7 % | Antiproliferative activity against human A431 cells at 10 uM after 48 hrs by MTT assay | ChEMBL. | 18680358 |
Inhibition (functional) | = 18 % | Antiproliferative activity against human A431 cells at 25 uM after 48 hrs by MTT assay | ChEMBL. | 18680358 |
Inhibition (functional) | = 40 % | Antiproliferative activity against human A431 cells at 50 uM after 48 hrs by MTT assay | ChEMBL. | 18680358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.