Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 0.0468 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0249 | 0.7809 | 1 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0224 | 0.6955 | 0.8907 |
Mycobacterium tuberculosis | Probable reductase | 0.0224 | 0.6955 | 0.8907 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0224 | 0.6955 | 0.8907 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0224 | 0.6955 | 0.8907 |
Schistosoma mansoni | hypothetical protein | 0.0039 | 0.0634 | 0.0634 |
Trypanosoma brucei | trypanothione reductase | 0.0098 | 0.2659 | 1 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0034 | 0.0468 | 0.176 |
Mycobacterium ulcerans | flavoprotein disulfide reductase | 0.0034 | 0.0468 | 1 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0098 | 0.2659 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0034 | 0.0468 | 0.176 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0034 | 0.0468 | 0.176 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0034 | 0.0468 | 0.176 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0034 | 0.0468 | 0.176 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0046 | 0.0862 | 0.3242 |
Plasmodium falciparum | glutathione reductase | 0.0098 | 0.2659 | 1 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 0.176 |
Echinococcus multilocularis | Basic leucine zipper (bZIP) transcription | 0.0039 | 0.0634 | 0.2382 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0634 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0034 | 0.0468 | 0.176 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0249 | 0.7809 | 1 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0034 | 0.0468 | 0.176 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0034 | 0.0468 | 0.176 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0098 | 0.2659 | 1 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 0.176 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0098 | 0.2659 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0098 | 0.2659 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0862 | 0.3242 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0098 | 0.2659 | 1 |
Mycobacterium tuberculosis | Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot | 0.0034 | 0.0468 | 0.0599 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0249 | 0.7809 | 1 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0034 | 0.0468 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 0.176 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0634 | 1 |
Treponema pallidum | NADH oxidase | 0.0034 | 0.0468 | 1 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0034 | 0.0468 | 1 |
Echinococcus granulosus | Basic leucine zipper bZIP transcription | 0.0039 | 0.0634 | 0.2382 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0034 | 0.0468 | 0.176 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 0.176 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0224 | 0.6955 | 0.8907 |
Brugia malayi | hypothetical protein | 0.0039 | 0.0634 | 0.2382 |
Brugia malayi | Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein | 0.0025 | 0.016 | 0.06 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0046 | 0.0862 | 0.3242 |
Plasmodium falciparum | glutathione reductase | 0.0034 | 0.0468 | 0.176 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0224 | 0.6955 | 0.8907 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0249 | 0.7809 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0862 | 0.0862 |
Loa Loa (eye worm) | glutathione reductase | 0.0098 | 0.2659 | 1 |
Brugia malayi | Thioredoxin reductase | 0.0098 | 0.2659 | 1 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0046 | 0.0862 | 0.3242 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0034 | 0.0468 | 0.176 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0.0468 | 1 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0034 | 0.0468 | 0.176 |
Toxoplasma gondii | thioredoxin reductase | 0.0098 | 0.2659 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0862 | 0.0862 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0634 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0034 | 0.0468 | 0.176 |
Plasmodium vivax | glutathione reductase, putative | 0.0098 | 0.2659 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0034 | 0.0468 | 0.5 |
Brugia malayi | alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase | 0.0025 | 0.016 | 0.06 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0098 | 0.2659 | 0.3406 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0862 | 0.3242 |
Brugia malayi | glutathione reductase | 0.0098 | 0.2659 | 1 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0034 | 0.0468 | 1 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0034 | 0.0468 | 1 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0034 | 0.0468 | 0.176 |
Schistosoma mansoni | transcription factor LCR-F1 | 0.0039 | 0.0634 | 0.0634 |
Leishmania major | trypanothione reductase | 0.0098 | 0.2659 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase | 0.0034 | 0.0468 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0046 | 0.0862 | 0.3242 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0046 | 0.0862 | 0.0862 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0098 | 0.2659 | 1 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0034 | 0.0468 | 0.176 |
Entamoeba histolytica | hypothetical protein | 0.0039 | 0.0634 | 1 |
Mycobacterium ulcerans | dihydrolipoamide dehydrogenase, LpdB | 0.0034 | 0.0468 | 1 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | Antiparasitic activity against chloroquine-sensitive Plasmodium falciparum Ghana assessed as reduction in parasite growth after 3 days by fluorimetry | ChEMBL. | 20194690 | |
Activity (functional) | Antileishmanial activity against Leishmania infantum MHOM/MA/67/ITMAP263 intracellular amastigotes assessed as reduction in parasite growth after 3 days by fluorometrically | ChEMBL. | 20194690 | |
Activity (functional) | Antitrypanosomal activity against Trypanosoma cruzi Tulahuen CL2 s-galactosidase strain assessed as reduction in parasite growth after 3 days by fluorometrically | ChEMBL. | 20194690 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.