Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Mus musculus | melanocortin 5 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 4 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 1 receptor | Starlite/ChEMBL | References |
Mus musculus | melanocortin 3 receptor | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | hypothetical protein | melanocortin 5 receptor | 372 aa | 314 aa | 21.0 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7886 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9228 | 1 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0191 | 0.0242 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3818 | 0.4014 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.4076 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0058 | 0.724 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.2951 | 0.4076 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.0535 | 0.0679 |
Brugia malayi | Bromodomain containing protein | 0.0037 | 0.3378 | 0.2673 |
Loa Loa (eye worm) | hypothetical protein | 0.0041 | 0.4163 | 0.4395 |
Loa Loa (eye worm) | hypothetical protein | 0.0037 | 0.3391 | 0.3541 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.0535 | 0.0739 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.0535 | 0.0739 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (functional) | = 25 % | Agonist activity at mouse MC3R expressed in HEK293 cells at 100 uM by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
EC50 (functional) | = 8.03 nM | Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
EC50 (functional) | = 12.8 nM | Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
EC50 (functional) | = 540 nM | Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
FC (functional) | = 2 | Agonist activity at mouse MC5R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide | ChEMBL. | 18800761 |
FC (functional) | = 5 | Agonist activity at mouse MC1R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide | ChEMBL. | 18800761 |
FC (functional) | = 6 | Agonist activity at mouse MC4R expressed in HEK293 cells by CRE/beta-galactosidase reporter gene assay relative to Ac-His-DPhe7-Arg-Trp-NH2 peptide | ChEMBL. | 18800761 |
Kd (functional) | = 6.79 | Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
Ki (functional) | = 6170 nM | Antagonist activity at mouse MC3R expressed in HEK293 cells assessed as effect on MT2 peptide-induced response by CRE/beta-galactosidase reporter gene assay | ChEMBL. | 18800761 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.