Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | leukotriene A4 hydrolase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target/s | Ortholog Group |
---|---|---|---|
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus granulosus | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Schistosoma japonicum | ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Candida albicans | leukotriene A4 hydrolase/leucyl aminopeptidase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | Get druggable targets OG5_129538 | All targets in OG5_129538 |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Leishmania major | aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 | leukotriene A4 hydrolase | 611 aa | 508 aa | 22.8 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | microtubule associated protein 2 | 0.0729 | 1 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0053 | 0.0505 | 0.1373 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.014 | 0.5 |
Brugia malayi | MH2 domain containing protein | 0.0126 | 0.1537 | 0.9812 |
Schistosoma mansoni | hypothetical protein | 0.0036 | 0.0271 | 0.0271 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.014 | 0.5 |
Brugia malayi | hypothetical protein | 0.0128 | 0.1566 | 1 |
Plasmodium falciparum | ataxin-2 like protein, putative | 0.0027 | 0.014 | 0.5 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0126 | 0.1537 | 0.4174 |
Brugia malayi | hypothetical protein | 0.0027 | 0.014 | 0.0893 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0053 | 0.0505 | 0.3227 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0036 | 0.0271 | 0.1733 |
Loa Loa (eye worm) | hypothetical protein | 0.0027 | 0.014 | 0.038 |
Schistosoma mansoni | leukotriene A4 hydrolase (M01 family) | 0.0279 | 0.3681 | 0.3681 |
Echinococcus multilocularis | leukotriene A 4 hydrolase | 0.0279 | 0.3681 | 0.3681 |
Trypanosoma brucei | PAB1-binding protein , putative | 0.0027 | 0.014 | 0.5 |
Leishmania major | hypothetical protein, conserved | 0.0027 | 0.014 | 0.5 |
Echinococcus granulosus | leukotriene A 4 hydrolase | 0.0279 | 0.3681 | 0.3681 |
Brugia malayi | hypothetical protein | 0.0017 | 0.0007 | 0.0047 |
Schistosoma mansoni | microtubule-associated protein tau | 0.0729 | 1 | 1 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0126 | 0.1537 | 0.4174 |
Plasmodium vivax | ataxin-2 like protein, putative | 0.0027 | 0.014 | 0.5 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0053 | 0.0505 | 0.3227 |
Loa Loa (eye worm) | hypothetical protein | 0.0053 | 0.0505 | 0.1373 |
Trypanosoma cruzi | PAB1-binding protein , putative | 0.0027 | 0.014 | 0.5 |
Loa Loa (eye worm) | leukotriene A4 hydrolase | 0.0279 | 0.3681 | 1 |
Toxoplasma gondii | LsmAD domain-containing protein | 0.0027 | 0.014 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0036 | 0.0271 | 0.0737 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
IC50 (binding) | = 22 nM | Inhibition of human recombinant LTA4-h by peptidase assay | ChEMBL. | 18394906 |
IC50 (functional) | = 3100 nM | Inhibition of calcium ionophore-induced LTB4 synthesis in human whole blood after 15 mins by ELISA | ChEMBL. | 18394906 |
Species name | Source | Reference | Is orphan |
---|---|---|---|
Homo sapiens | ChEMBL23 | 18394906 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.