Detailed information for compound 1002980

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 269.27 | Formula: C16H12FNO2
  • H donors: 1 H acceptors: 1 LogP: 3.26 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: CNc1ccc(cc1)c1cc(=O)c2c(o1)ccc(c2)F
  • InChi: 1S/C16H12FNO2/c1-18-12-5-2-10(3-6-12)16-9-14(19)13-8-11(17)4-7-15(13)20-16/h2-9,18H,1H3
  • InChiKey: WTLZONGTQDIGMQ-UHFFFAOYSA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Echinococcus granulosus dna polymerase eta 0.0044 0.6699 0.6699
Echinococcus multilocularis lamin dm0 0.0031 0.4494 0.4494
Loa Loa (eye worm) RNA binding protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.0006 0.0191 0.0191
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.2413 0.5
Leishmania major DNA polymerase eta, putative 0.0031 0.4465 0.6568
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0016 0.203 0.203
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.6699 1
Loa Loa (eye worm) hypothetical protein 0.0044 0.6699 0.6699
Schistosoma mansoni DNA polymerase IV / kappa 0.0006 0.0191 0.0191
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.2413 0.2413
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.2413 0.5
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 1 1
Toxoplasma gondii exonuclease III APE 0.0019 0.2413 0.5197
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0031 0.4494 0.4494
Loa Loa (eye worm) intermediate filament protein 0.0031 0.4494 0.4494
Echinococcus multilocularis dna polymerase eta 0.0044 0.6699 0.6699
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Entamoeba histolytica deoxycytidyl transferase, putative 0.0019 0.2424 1
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.6699 1
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.2413 0.9948
Schistosoma mansoni lamin 0.0031 0.4494 0.4494
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.2424 0.3432
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0019 0.2424 0.2424
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.2424 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0015 0.1748 0.1748
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.6699 0.6699
Brugia malayi Intermediate filament tail domain containing protein 0.0031 0.4494 0.4494
Loa Loa (eye worm) hypothetical protein 0.0014 0.165 0.165
Leishmania major DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Loa Loa (eye worm) hypothetical protein 0.0015 0.1748 0.1748
Echinococcus multilocularis musashi 0.0031 0.4494 0.4494
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.1419 0.1887
Schistosoma mansoni intermediate filament proteins 0.0031 0.4494 0.4494
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.4465 1
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.2413 0.3414
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.2413 0.2413
Leishmania major DNA polymerase eta, putative 0.0044 0.6699 1
Echinococcus granulosus intermediate filament protein 0.0031 0.4494 0.4494
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0019 0.2424 0.2424
Schistosoma mansoni lamin 0.0031 0.4494 0.4494
Echinococcus granulosus lamin 0.0031 0.4494 0.4494
Brugia malayi ImpB/MucB/SamB family protein 0.0019 0.2424 0.2424
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0019 0.2424 1
Brugia malayi polk-prov protein 0.0006 0.0191 0.0191
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0019 0.2424 0.2424
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.1419 0.1887
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.2413 0.3414
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.2413 0.2413
Schistosoma mansoni ap endonuclease 0.0019 0.2413 0.2413
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0019 0.2424 0.3432
Onchocerca volvulus 0.0031 0.4494 1
Mycobacterium ulcerans DNA polymerase IV 0.0019 0.2424 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.2413 0.3414
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.2424 0.3432
Loa Loa (eye worm) hypothetical protein 0.0014 0.165 0.165
Trypanosoma brucei DNA polymerase kappa, putative 0.0013 0.1419 0.1887
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Trypanosoma brucei unspecified product 0.0013 0.1419 0.1887
Trypanosoma brucei unspecified product 0.0019 0.2424 0.3432
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0019 0.2424 0.2424
Echinococcus granulosus lamin dm0 0.0031 0.4494 0.4494
Echinococcus multilocularis tar DNA binding protein 0.0063 1 1
Schistosoma mansoni DNA polymerase eta 0.0044 0.6699 0.6699
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0015 0.1748 0.1748
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.2413 0.2413
Brugia malayi cytoplasmic intermediate filament protein 0.0016 0.203 0.203
Echinococcus multilocularis lamin 0.0031 0.4494 0.4494
Trichomonas vaginalis DNA polymerase eta, putative 0.0019 0.2424 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2413 1
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.2413 1
Trypanosoma brucei unspecified product 0.0013 0.1419 0.1887
Mycobacterium tuberculosis Conserved hypothetical protein 0.0019 0.2424 1
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Brugia malayi RNA recognition motif domain containing protein 0.0063 1 1
Loa Loa (eye worm) hypothetical protein 0.003 0.4397 0.4397
Loa Loa (eye worm) TAR-binding protein 0.0063 1 1
Giardia lamblia DINP protein human, muc B family 0.0019 0.2424 1
Echinococcus granulosus dna polymerase kappa 0.0019 0.2424 0.2424
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.4465 0.6568
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.2413 0.3414
Onchocerca volvulus 0.0031 0.4494 1
Brugia malayi intermediate filament protein 0.0031 0.4494 0.4494
Trypanosoma brucei DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Trypanosoma brucei DNA polymerase IV, putative 0.0019 0.2424 0.3432
Trypanosoma cruzi DNA polymerase kappa, putative 0.0019 0.2424 0.3432
Schistosoma mansoni ap endonuclease 0.0019 0.2413 0.2413
Echinococcus granulosus tar DNA binding protein 0.0063 1 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.2413 0.9948
Schistosoma mansoni terminal deoxycytidyl transferase 0.0019 0.2424 0.2424
Brugia malayi TAR-binding protein 0.0063 1 1
Echinococcus multilocularis dna polymerase kappa 0.0019 0.2424 0.2424
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0019 0.2424 1
Loa Loa (eye worm) hypothetical protein 0.0031 0.4494 0.4494

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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