Detailed information for compound 1003723

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1206.88 | Formula: C56H38O31
  • H donors: 20 H acceptors: 25 LogP: 3 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 4
  • SMILES: O[C@H]1Cc2c(O)cc(c(c2O[C@@H]1c1ccc(c(c1)O)O)[C@@H]1[C@H]2OC(=O)c3c1c(O)c(O)c(c3c1c3C(=O)O[C@H]2[C@H]2OC(=O)c4cc(O)c(c(c4c4c(C(=O)OC[C@H]2OC(=O)c2c(c3c(c(c1O)O)O)c(O)c(c(c2)O)O)cc(c(c4O)O)O)O)O)O)O
  • InChi: 1S/C56H38O31/c57-15-2-1-10(3-17(15)59)47-22(64)4-11-16(58)8-18(60)27(48(11)84-47)32-31-34-30(43(73)46(76)44(31)74)29-33-28(41(71)45(75)42(29)72)26-14(7-21(63)37(67)40(26)70)53(78)83-23-9-82-52(77)12-5-19(61)35(65)38(68)24(12)25-13(6-20(62)36(66)39(25)69)54(79)85-49(23)51(87-56(33)81)50(32)86-55(34)80/h1-3,5-8,22-23,32,47,49-51,57-76H,4,9H2/t22-,23+,32-,47+,49-,50+,51-/m0/s1
  • InChiKey: DRHVFLXLYQESEQ-YGJAGGILSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus Alhambra homolog 0.0064 0.0833 0.0651
Trichomonas vaginalis AGC family protein kinase 0.0088 0.1309 0.1082
Trichomonas vaginalis set domain proteins, putative 0.0524 1 1
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0088 0.1309 0.1493
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Echinococcus granulosus cpg binding protein 0.0034 0.0232 0.0265
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Loa Loa (eye worm) hypothetical protein 0.0333 0.6193 0.7089
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0086 0.126 0.1032
Loa Loa (eye worm) AGC/NDR protein kinase 0.0088 0.1309 0.1493
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Brugia malayi beta-lactamase family protein 0.0035 0.0254 0.0285
Brugia malayi Protein kinase domain containing protein 0.0088 0.1309 0.1493
Brugia malayi C1-like domain containing protein 0.023 0.4128 0.4724
Brugia malayi F/Y-rich N-terminus family protein 0.0033 0.0214 0.0239
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1309 0.132
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.0083 0.1198 0.1369
Loa Loa (eye worm) PHD-finger family protein 0.0064 0.0833 0.0949
Onchocerca volvulus 0.0035 0.0254 0.006
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.008 0.1149 0.1133
Echinococcus multilocularis protein kinase c iota type 0.0268 0.4894 0.5592
Schistosoma mansoni protein kinase C 0.0088 0.13 0.1309
Brugia malayi RhoGEF domain containing protein 0.008 0.1149 0.131
Giardia lamblia Fructose-bisphosphate aldolase 0.0316 0.5851 1
Echinococcus granulosus serine:threonine protein kinase N2 0.0088 0.1309 0.1495
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0254 0.5
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1309 0.132
Brugia malayi Pre-SET motif family protein 0.0067 0.0878 0.1
Loa Loa (eye worm) hypothetical protein 0.0333 0.6193 0.7089
Loa Loa (eye worm) hypothetical protein 0.0085 0.1248 0.1424
Schistosoma mansoni cpg binding protein 0.0034 0.0232 0.0063
Echinococcus multilocularis myotubularin protein 13 0.0085 0.1248 0.1426
Echinococcus granulosus myotubularin protein 13 0.0085 0.1248 0.1426
Loa Loa (eye worm) hypothetical protein 0.0143 0.2396 0.2739
Echinococcus granulosus serine:threonine protein kinase N2 0.0169 0.2919 0.3336
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0154 0.2627 1
Echinococcus granulosus peregrin 0.0064 0.0833 0.0952
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0035 0.0254 0.0285
Schistosoma mansoni unc-13 (munc13) 0.0088 0.13 0.1309
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Schistosoma mansoni unc-13 (munc13) 0.0088 0.13 0.1309
Toxoplasma gondii diacylglycerol kinase, putative 0.008 0.1149 0.8485
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0067 0.0878 0.1003
Trichomonas vaginalis AGC family protein kinase 0.0088 0.1309 0.1082
Loa Loa (eye worm) jmjC domain-containing protein 0.008 0.114 0.13
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Trypanosoma brucei rac serine-threonine kinase, putative 0.0093 0.1407 1
Echinococcus granulosus RNA directed DNA polymerase 0.0143 0.2396 0.2738
Brugia malayi beta-lactamase 0.0035 0.0254 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Loa Loa (eye worm) RhoGAP domain-containing protein 0.008 0.1149 0.131
Echinococcus granulosus Rac GTPase activating protein 1 0.008 0.1149 0.1313
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0035 0.0254 0.0285
Brugia malayi Protein kinase domain containing protein 0.0088 0.1309 0.1493
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0211 0.3756 0.4292
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0088 0.1309 0.1495
Brugia malayi Hr1 repeat family protein 0.0088 0.1309 0.1493
Schistosoma mansoni rac gtpase activating protein 0.008 0.1149 0.1133
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0088 0.1309 0.1493
Schistosoma mansoni hypothetical protein 0.0462 0.8752 1
Onchocerca volvulus 0.0147 0.2479 0.233
Brugia malayi Variant SH3 domain containing protein 0.008 0.1149 0.131
Echinococcus multilocularis cpg binding protein 0.0034 0.0232 0.0265
Loa Loa (eye worm) raf kinase 0.008 0.1149 0.131
Loa Loa (eye worm) Ras association domain family 1 isoform A 0.008 0.1149 0.131
Loa Loa (eye worm) hypothetical protein 0.0147 0.2479 0.2834
Echinococcus multilocularis serine:threonine protein kinase N2 0.0255 0.4631 0.5291
Echinococcus multilocularis lysine specific demethylase 5A 0.0078 0.1103 0.1261
Echinococcus multilocularis guanine nucleotide exchange factor VAV2 0.008 0.1149 0.1313
Echinococcus granulosus lysine specific demethylase 5A 0.008 0.114 0.1303
Brugia malayi protein kinase C II. 0.0343 0.6382 0.7307
Echinococcus multilocularis Diacylglycerol kinase theta 0.008 0.1149 0.1313
Echinococcus granulosus protein kinase c eta type 0.008 0.1149 0.1313
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Schistosoma mansoni jumonji domain containing protein 0.0168 0.2891 0.3165
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0088 0.1309 0.1495
Brugia malayi protein kinase C3,putative 0.0182 0.3182 0.364
Brugia malayi Ras association domain family 1 isoform A 0.008 0.1149 0.131
Toxoplasma gondii AGC kinase 0.0088 0.1309 1
Entamoeba histolytica protein kinase, putative 0.0088 0.1309 0.034
Loa Loa (eye worm) hypothetical protein 0.0088 0.13 0.1484
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Brugia malayi Bromodomain containing protein 0.0064 0.0833 0.0949
Brugia malayi beta-lactamase family protein 0.0035 0.0254 0.0285
Schistosoma mansoni serine/threonine kinase 0.0088 0.1309 0.132
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0254 0.0089
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0878 0.0817
Echinococcus granulosus geminin 0.035 0.6521 0.7451
Echinococcus multilocularis N chimaerin 0.008 0.1149 0.1313
Echinococcus granulosus protein kinase C gamma type 0.0239 0.4307 0.4922
Echinococcus granulosus unc 13 munc13 0.0088 0.13 0.1485
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.5851 1
Onchocerca volvulus 0.0333 0.6193 0.6117
Brugia malayi Pre-SET motif family protein 0.0461 0.8733 1
Treponema pallidum fructose-bisphosphate aldolase 0.0316 0.5851 0.5
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0833 0.5492
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0067 0.0878 0.5917
Echinococcus granulosus histone lysine methyltransferase setb 0.0067 0.0878 0.1003
Brugia malayi RhoGAP domain containing protein 0.008 0.1149 0.131
Loa Loa (eye worm) RasGEF domain-containing protein 0.008 0.1149 0.131
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0316 0.5851 1
Loa Loa (eye worm) AGC/PKN protein kinase 0.0088 0.1309 0.1493
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1309 0.132
Trichomonas vaginalis AGC family protein kinase 0.0088 0.1309 0.1082
Echinococcus multilocularis protein kinase c eta type 0.008 0.1149 0.1313
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0071 0.0968 0.0922
Echinococcus granulosus protein kinase c epsilon type 0.0343 0.6382 0.7293
Schistosoma mansoni chimerin-related rho-gtpase-activating protein 0.008 0.1149 0.1133
Loa Loa (eye worm) hypothetical protein 0.0223 0.3996 0.4573
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0067 0.0878 0.1003
Onchocerca volvulus 0.0227 0.4079 0.3962
Plasmodium vivax hypothetical protein, conserved 0.0064 0.0833 0.9485
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0067 0.0878 0.0817
Brugia malayi Protein kinase domain containing protein 0.0083 0.1198 0.1366
Loa Loa (eye worm) AGC/AKT protein kinase 0.0093 0.1407 0.1607
Brugia malayi CXXC zinc finger family protein 0.0032 0.0195 0.0217
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0461 0.8733 1
Echinococcus multilocularis telomerase reverse transcriptase subunit 0.0143 0.2396 0.2738
Schistosoma mansoni serine/threonine protein kinase 0.0319 0.5908 0.6683
Onchocerca volvulus 0.0067 0.0878 0.0697
Echinococcus granulosus Protein kinase C brain isozyme 0.0319 0.5908 0.675
Brugia malayi diacylglycerol kinase 0.008 0.1149 0.131
Onchocerca volvulus 0.0035 0.0254 0.006
Schistosoma mansoni hypothetical protein 0.035 0.6521 0.7399
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Loa Loa (eye worm) jmjC domain-containing protein 0.0133 0.2201 0.2516
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0878 0.0817
Loa Loa (eye worm) beta-lactamase 0.0035 0.0254 0.0285
Echinococcus multilocularis serine:threonine protein kinase N2 0.0088 0.1309 0.1495
Brugia malayi RhoGAP domain containing protein 0.008 0.1149 0.131
Echinococcus multilocularis unc 13 (munc13) 0.0088 0.13 0.1485
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Schistosoma mansoni serine/threonine protein kinase 0.008 0.1149 0.1133
Echinococcus granulosus N chimaerin 0.008 0.1149 0.1313
Brugia malayi jmjC domain containing protein 0.0211 0.3756 0.4297
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0226 0.4054 1
Loa Loa (eye worm) hypothetical protein 0.0067 0.0878 0.1
Brugia malayi Protein kinase domain containing protein 0.0093 0.1407 0.1607
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0088 0.1309 0.1495
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.1198 0.119
Loa Loa (eye worm) CXXC zinc finger family protein 0.0032 0.0195 0.0217
Echinococcus granulosus protein kinase c iota type 0.0268 0.4894 0.5592
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0088 0.1309 0.1495
Echinococcus multilocularis raf serine:threonine protein kinase 0.008 0.1149 0.1313
Schistosoma mansoni serine/threonine protein kinase 0.0088 0.1309 0.132
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Entamoeba histolytica protein kinase, putative 0.0093 0.1407 0.055
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0154 0.2627 0.6245
Echinococcus granulosus NDR protein kinase 0.0088 0.1309 0.1495
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0064 0.0833 0.0765
Echinococcus multilocularis C2 calcium dependent membrane targeting 0.0088 0.13 0.1485
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.114 0.1123
Onchocerca volvulus 0.0088 0.13 0.1127
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.0083 0.1198 0.1369
Schistosoma mansoni jumonji/arid domain-containing protein 0.008 0.114 0.1123
Plasmodium vivax SET domain protein, putative 0.0067 0.0878 1
Loa Loa (eye worm) variant SH3 domain-containing protein 0.008 0.1149 0.131
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Schistosoma mansoni diacylglycerol kinase theta 0.008 0.1149 0.1133
Schistosoma mansoni diacylglycerol kinase theta 0.008 0.1149 0.1133
Echinococcus granulosus C2 calcium dependent membrane targeting 0.0088 0.13 0.1485
Loa Loa (eye worm) hypothetical protein 0.0414 0.7793 0.8923
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0088 0.1309 0.1495
Brugia malayi Phorbol esters/diacylglycerol binding domain 0.023 0.4128 0.4724
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0064 0.0815 0.0932
Entamoeba histolytica protein kinase, putative 0.0093 0.1407 0.055
Plasmodium vivax hypothetical protein, conserved 0.0035 0.0254 0.2826
Echinococcus granulosus dnaJ subfamily B 0.0462 0.8752 1
Onchocerca volvulus 0.0232 0.4178 0.4063
Plasmodium falciparum phd finger protein, putative 0.0064 0.0833 1
Echinococcus multilocularis geminin 0.035 0.6521 0.7451
Loa Loa (eye worm) CAMK/PKD protein kinase 0.0149 0.2528 0.289
Echinococcus multilocularis beta LACTamase domain containing family member 0.0035 0.0254 0.029
Brugia malayi Protein kinase c protein 2 0.0233 0.4196 0.4802
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Loa Loa (eye worm) hypothetical protein 0.011 0.1751 0.2
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0088 0.1309 0.1495
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0154 0.2627 1
Echinococcus multilocularis serine threonine protein kinase 0.0239 0.4307 0.4922
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0254 0.5
Schistosoma mansoni cpg binding protein 0.0034 0.0232 0.0063
Brugia malayi p70 ribosomal S6 kinase beta 0.0088 0.1309 0.1493
Loa Loa (eye worm) hypothetical protein 0.0064 0.0833 0.0949
Loa Loa (eye worm) hypothetical protein 0.0147 0.2479 0.2834
Entamoeba histolytica PH domain containing protein kinase, putative 0.0174 0.3018 0.3976
Schistosoma mansoni atypical protein kinase C 0.0275 0.5039 0.567
Schistosoma mansoni hypothetical protein 0.035 0.6521 0.7399
Echinococcus multilocularis RNA directed DNA polymerase 0.0143 0.2396 0.2738
Echinococcus granulosus guanine nucleotide exchange factor VAV2 0.008 0.1149 0.1313
Entamoeba histolytica protein kinase, putative 0.0088 0.1309 0.034
Schistosoma mansoni cpg binding protein 0.0032 0.0195 0.002
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0088 0.1309 0.1493
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0319 0.5908 0.675
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Brugia malayi Pleckstrin Homology Domain 0.0085 0.1248 0.1424
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0067 0.0878 0.0817
Schistosoma mansoni serine/threonine protein kinase 0.0343 0.6382 0.7237
Loa Loa (eye worm) hypothetical protein 0.0227 0.4079 0.4668
Onchocerca volvulus 0.0035 0.0254 0.006
Toxoplasma gondii PHD-finger domain-containing protein 0.0064 0.0833 0.5492
Schistosoma mansoni protein kinase C mu 0.008 0.1149 0.1133
Echinococcus multilocularis PHD finger protein rhinoceros 0.0064 0.0833 0.0952
Loa Loa (eye worm) hypothetical protein 0.0232 0.4178 0.4781
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0088 0.1309 0.1493
Schistosoma mansoni hypothetical protein 0.0064 0.0833 0.0765
Brugia malayi diacylglycerol kinase 0.008 0.1149 0.131
Schistosoma mansoni serine/threonine protein kinase 0.0319 0.5908 0.6683
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0035 0.0254 0.0089
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0316 0.5851 0.5743
Echinococcus multilocularis protein kinase c epsilon type 0.0343 0.6382 0.7293
Brugia malayi jmjC domain containing protein 0.008 0.114 0.13
Echinococcus multilocularis peregrin 0.0064 0.0833 0.0952
Loa Loa (eye worm) hypothetical protein 0.0035 0.0254 0.0285
Trichomonas vaginalis AGC family protein kinase 0.0093 0.1407 0.1184
Echinococcus granulosus jumonji domain containing protein 0.009 0.1336 0.1527
Schistosoma mansoni serine/threonine protein kinase 0.0083 0.1198 0.119
Echinococcus granulosus beta LACTamase domain containing family member 0.0035 0.0254 0.029
Echinococcus granulosus PHD finger protein rhinoceros 0.0064 0.0833 0.0952
Echinococcus granulosus Diacylglycerol kinase theta 0.008 0.1149 0.1313
Schistosoma mansoni hypothetical protein 0.008 0.1149 0.1133
Loa Loa (eye worm) AGC/PKC/ALPHA protein kinase 0.0153 0.2596 0.2968
Schistosoma mansoni protein kinase C mu 0.023 0.4128 0.4608
Schistosoma mansoni vav2 0.0085 0.1248 0.1248
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0343 0.6382 0.7307
Echinococcus granulosus raf serine:threonine protein kinase 0.008 0.1149 0.1313
Echinococcus multilocularis serine:threonine protein kinase 38 0.0088 0.1309 0.1495
Brugia malayi PHD-finger family protein 0.0064 0.0833 0.0949
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.019 0.3328 0.3807
Echinococcus multilocularis dnaJ subfamily B 0.0462 0.8752 1
Leishmania major hypothetical protein, conserved 0.0035 0.0254 0.5
Echinococcus multilocularis Rac GTPase activating protein 1 0.008 0.1149 0.1313
Loa Loa (eye worm) hypothetical protein 0.008 0.1149 0.131
Loa Loa (eye worm) CAMK/PKD protein kinase 0.023 0.4128 0.4724
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0821 0.5378
Echinococcus multilocularis jumonji domain containing protein 0.009 0.1336 0.1527
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0211 0.3756 0.4292
Loa Loa (eye worm) hypothetical protein 0.0422 0.7953 0.9106
Loa Loa (eye worm) hypothetical protein 0.0333 0.6193 0.7089

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human TE671 cells by tetrazolium salt-based colorimetric assay ChEMBL. 1431932
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human HCT8 cells by tetrazolium salt-based colorimetric assay ChEMBL. 1431932
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human A549 cells by tetrazolium salt-based colorimetric assay ChEMBL. 1431932
ED50 (functional) > 10 ug ml-1 Cytotoxicity against human KB cells by tetrazolium salt-based colorimetric assay ChEMBL. 1431932

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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