Detailed information for compound 1003939

Basic information

Technical information
  • TDR Targets ID: 1003939
  • Name: [(3S,5R,6S,7S,10R,11R,13R,14R,17R)-6-acetylox y-3,5,11-trihydroxy-10,13-dimethyl-17-[(2R)-6 -methylheptan-2-yl]-1,2,3,4,6,7,11,12,14,15,1 6,17-dodecahydrocyclopenta[a]phenanthren-7-yl ] acetate
  • MW: 534.724 | Formula: C31H50O7
  • H donors: 3 H acceptors: 5 LogP: 4.51 Rotable bonds: 9
    Rule of 5 violations (Lipinski): 2
  • SMILES: CC(CCC[C@H]([C@H]1CC[C@@H]2[C@]1(C)C[C@@H](O)C1=C2[C@H](OC(=O)C)[C@@H]([C@@]2([C@]1(C)CC[C@@H](C2)O)O)OC(=O)C)C)C
  • InChi: 1S/C31H50O7/c1-17(2)9-8-10-18(3)22-11-12-23-25-26(24(35)16-29(22,23)6)30(7)14-13-21(34)15-31(30,36)28(38-20(5)33)27(25)37-19(4)32/h17-18,21-24,27-28,34-36H,8-16H2,1-7H3/t18-,21+,22-,23+,24-,27+,28+,29-,30-,31+/m1/s1
  • InChiKey: PLCXDTMXCFEKKN-SQXGGVHUSA-N  


Substructure search Similarity search

Network

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Synonyms

  • [(3S,5R,6S,7S,10R,11R,13R,14R,17R)-6-acetoxy-17-[(1R)-1,5-dimethylhexyl]-3,5,11-trihydroxy-10,13-dimethyl-1,2,3,4,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-yl] acetate
  • acetic acid [(3S,5R,6S,7S,10R,11R,13R,14R,17R)-6-acetoxy-17-[(1R)-1,5-dimethylhexyl]-3,5,11-trihydroxy-10,13-dimethyl-1,2,3,4,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-yl] ester
  • [(3S,5R,6S,7S,10R,11R,13R,14R,17R)-6-acetyloxy-3,5,11-trihydroxy-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-1,2,3,4,6,7,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-7-yl] ethanoate

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0244 0.4276
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Echinococcus multilocularis neuropeptide FF receptor 2 0.0086 0.0411 0.0411
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0121 0.488
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1045 0.2582
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Echinococcus multilocularis ubiquitin specific protease 41 0.0042 0.0137 0.0137
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0112 0.0569 1
Onchocerca volvulus 0.0098 0.0482 0.1752
Onchocerca volvulus Neuropeptide F receptor homolog 0.0086 0.0411 0.1492
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0205 0.0205
Brugia malayi AKH receptor 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi acetyltransferase, GNAT family protein 0.0143 0.0757 0.2684
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0042 0.0137 0.0485
Schistosoma mansoni hypothetical protein 0.0127 0.0662 0.1636
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.0086 0.0411 0.1015
Brugia malayi ImpB/MucB/SamB family protein 0.0044 0.0151 0.0537
Schistosoma mansoni amine GPCR 0.0086 0.0411 0.1015
Brugia malayi Pre-SET motif family protein 0.0412 0.2404 0.8522
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0167 0.0591
Echinococcus granulosus 7TM GPCR rhodopsin 0.0086 0.0411 0.1015
Schistosoma mansoni alpha-1 adrenergic receptor 0.0086 0.0411 0.1015
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0569 0.2565
Echinococcus granulosus transcription factor Dp 1 0.0037 0.0109 0.027
Echinococcus granulosus g-protein coupled receptor 0.0086 0.0411 0.1015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Schistosoma mansoni opsin-like receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0167 0.0167
Onchocerca volvulus 0.0025 0.0035 0.0129
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0165 0.0409
Brugia malayi Calcitonin receptor-like protein seb-1 0.0403 0.2346 0.8316
Echinococcus granulosus somatostatin receptor 0.0086 0.0411 0.1015
Onchocerca volvulus Dopamine\/Ecdysteroid receptor homolog 0.0086 0.0411 0.1492
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.03
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0042 0.014 0.5643
Trichomonas vaginalis maltase-glucoamylase, putative 0.0035 0.0098 0.0088
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Toxoplasma gondii exonuclease III APE 0.0039 0.0121 0.2118
Brugia malayi Serotonin receptor 0.0086 0.0411 0.1456
Schistosoma mansoni hypothetical protein 0.0086 0.0411 0.1015
Onchocerca volvulus 0.0086 0.0411 0.1492
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0127 0.0662 0.0662
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0035 0.0035
Brugia malayi sulfakinin receptor protein 0.0086 0.0411 0.1456
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0035 0.0126
Onchocerca volvulus 0.0086 0.0411 0.1492
Brugia malayi G protein-coupled receptor 0.0086 0.0411 0.1456
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0118 0.0603 0.1454
Trypanosoma cruzi DNA polymerase eta, putative 0.0031 0.0072 0.0173
Echinococcus multilocularis lysine specific demethylase 5A 0.0071 0.0319 0.0319
Loa Loa (eye worm) hypothetical protein 0.0044 0.0151 0.0537
Schistosoma mansoni jumonji domain containing protein 0.0154 0.0822 0.2031
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus multilocularis neuropeptide receptor A26 0.0086 0.0411 0.0411
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0403 0.2346 0.8316
Brugia malayi G protein-coupled receptor F59B2.13 0.0086 0.0411 0.1456
Brugia malayi Glycosyl hydrolases family 31 protein 0.0035 0.0098 0.0347
Echinococcus granulosus geminin 0.0681 0.4046 1
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0035 0.0126
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Schistosoma mansoni hypothetical protein 0.0098 0.0482 0.1191
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0248 0.0613
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0411 0.0411
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0121 0.012
Echinococcus multilocularis microtubule associated protein 2 0.0671 0.3989 0.3989
Treponema pallidum fructose-bisphosphate aldolase 0.1189 0.7156 1
Echinococcus granulosus peregrin 0.0063 0.0265 0.0655
Schistosoma mansoni hypothetical protein 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.006 0.0248 0.4352
Echinococcus multilocularis allatostatin A receptor 0.0086 0.0411 0.0411
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0411 0.1015
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0035 0.0035
Plasmodium vivax hypothetical protein, conserved 0.0059 0.0244 0.9826
Echinococcus multilocularis serotonin receptor 0.0086 0.0411 0.0411
Echinococcus multilocularis jumonji domain containing protein 0.0082 0.0385 0.0385
Brugia malayi exodeoxyribonuclease III family protein 0.0039 0.0121 0.0429
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1189 0.7156 1
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0852 0.0852
Echinococcus granulosus g protein coupled receptor 0.0086 0.0411 0.1015
Brugia malayi hypothetical protein 0.0035 0.01 0.0354
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0411 0.1015
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Schistosoma mansoni glutaminase 0.0265 0.1503 0.3714
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0411 0.0411
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0134 0.0702 0.2488
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0137 0.0645
Loa Loa (eye worm) hypothetical protein 0.006 0.0248 0.0879
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.0569 0.0749
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0137 0.0338
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0112 0.0569 0.1568
Schistosoma mansoni hypothetical protein 0.0127 0.0662 0.1636
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0411 0.0411
Trypanosoma brucei tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0274 0.1293
Echinococcus multilocularis dro:myosuppressin receptor 0.0086 0.0411 0.0411
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0088
Mycobacterium tuberculosis Probable oxidoreductase 0.0118 0.0603 0.1454
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0569 0.2565
Trypanosoma brucei aminopeptidase, putative 0.0025 0.0035 0.0165
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.171
Brugia malayi RE15519p 0.0086 0.0411 0.1456
Echinococcus granulosus microtubule associated protein 2 0.0671 0.3989 0.9857
Schistosoma mansoni neuropeptide f receptor 76f 0.0086 0.0411 0.1015
Brugia malayi PHD-finger family protein 0.0021 0.0011 0.0041
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0702 0.0702
Schistosoma mansoni hypothetical protein 0.0289 0.1649 0.4076
Echinococcus granulosus lysosomal alpha glucosidase 0.0158 0.0852 0.2106
Brugia malayi G-protein-linked acetylcholine receptor protein 2, putative 0.0086 0.0411 0.1456
Trypanosoma cruzi hypothetical protein, conserved 0.0035 0.0098 0.03
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0021 0.001 0.001
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0127 0.0662 0.1636
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.0086 0.0411 0.0411
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0167 0.6727
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0031 0.0072 0.1248
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0042 0.0137 0.0026
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus PHD finger protein rhinoceros 0.0059 0.0244 0.0602
Echinococcus multilocularis G protein coupled receptor 139 0.0086 0.0411 0.0411
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0042 0.014 0.2451
Toxoplasma gondii histone lysine methyltransferase SET1 0.0064 0.0277 0.4864
Echinococcus granulosus tyrosyl DNA phosphodiesterase 1 0.0064 0.0274 0.0677
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0143 0.0757 0.1871
Brugia malayi Melibiase family protein 0.0074 0.0334 0.1184
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0042 0.0137 0.0485
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0581 0.3436 1
Brugia malayi Inositol-1 0.0112 0.0569 0.2016
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.0086 0.0411 0.0411
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0137 0.0142
Brugia malayi Serotonin/octopamine receptor family protein 7 0.0086 0.0411 0.1456
Brugia malayi gonadotropin-releasing hormone receptor 2 0.0086 0.0411 0.1456
Onchocerca volvulus 0.0086 0.0411 0.1492
Brugia malayi Serotonin receptor 0.0086 0.0411 0.1456
Schistosoma mansoni cpg binding protein 0.0033 0.0083 0.0206
Entamoeba histolytica acetyltransferase, GNAT family 0.0039 0.0118 0.0116
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0035 0.0098 0.0347
Brugia malayi larval opioid receptor 0.0086 0.0411 0.1456
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0137 0.0488
Schistosoma mansoni myosin xvIII 0.0086 0.0411 0.1015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.056 0.1383
Loa Loa (eye worm) hypothetical protein 0.0021 0.0011 0.0041
Schistosoma mansoni amine GPCR 0.0086 0.0411 0.1015
Loa Loa (eye worm) acetyltransferase 0.0143 0.0757 0.2684
Brugia malayi Dopamine receptor protein 1, putative (partial) 0.0086 0.0411 0.1456
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.0088
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0115 0.0584 0.0584
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.006 0.0248 0.0248
Echinococcus granulosus inositol monophosphatase 1 0.0112 0.0569 0.1406
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0039 0.0121 0.0299
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0205 0.0505
Echinococcus multilocularis dnaJ subfamily B 0.0442 0.2586 0.2586
Echinococcus granulosus alpha 1A adrenergic receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis sex peptide receptor 0.0086 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0165 0.0586
Plasmodium vivax glutathione reductase, putative 0.0046 0.0167 0.6727
Echinococcus granulosus leukotriene A 4 hydrolase 0.047 0.2759 0.6818
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Schistosoma mansoni amine GPCR 0.0086 0.0411 0.1015
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0039 0.0121 0.012
Brugia malayi Melatonin receptor type 1A 0.0086 0.0411 0.1456
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0569 0.2688
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0411 0.0411
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0411 0.0411
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0088
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Onchocerca volvulus 0.0086 0.0411 0.1492
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.0531 0.1236
Echinococcus multilocularis orexin receptor type 2 0.0086 0.0411 0.0411
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Schistosoma mansoni neuropeptide receptor 0.0086 0.0411 0.1015
Trichomonas vaginalis set domain proteins, putative 0.0469 0.2752 0.3814
Brugia malayi Bromodomain containing protein 0.0063 0.0265 0.0939
Loa Loa (eye worm) MBCTL1 0.0053 0.0205 0.0725
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0112 0.0569 0.0749
Schistosoma mansoni lipoxygenase 0.0115 0.0584 0.1444
Schistosoma mansoni aminopeptidase A (M01 family) 0.0025 0.0035 0.0088
Brugia malayi TATA binding protein associated factor 0.0025 0.0035 0.0126
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0035 0.0035
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0248 0.0613
Loa Loa (eye worm) peptidase family M1 containing protein 0.0025 0.0035 0.0126
Echinococcus granulosus GPCR family 2 0.0127 0.0662 0.1636
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0274 0.1147
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0411 0.1015
Echinococcus multilocularis geminin 0.0681 0.4046 0.4046
Trichomonas vaginalis glutaminase, putative 0.0265 0.1503 0.2061
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0143 0.0757 0.0757
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Brugia malayi Thioredoxin reductase 0.0046 0.0167 0.0591
Brugia malayi hypothetical protein 0.048 0.2821 1
Echinococcus granulosus tachykinin peptides receptor 99D 0.0086 0.0411 0.1015
Loa Loa (eye worm) glutathione reductase 0.0046 0.0167 0.0591
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.1189 0.7156 1
Onchocerca volvulus 0.006 0.0248 0.0901
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni alpha-glucosidase 0.0136 0.0717 0.1772
Schistosoma mansoni hypothetical protein 0.0127 0.0662 0.1636
Onchocerca volvulus 0.0025 0.0035 0.0129
Brugia malayi follicle stimulating hormone receptor 0.0086 0.0411 0.1456
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Plasmodium falciparum thioredoxin reductase 0.0046 0.0167 0.6847
Echinococcus granulosus neuropeptide FF receptor 2 0.0086 0.0411 0.1015
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0167 0.0631
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0165 0.0601
Echinococcus granulosus thyrotropin releasing hormone receptor 0.0086 0.0411 0.1015
Schistosoma mansoni hypothetical protein 0.0086 0.0411 0.1015
Echinococcus granulosus allatostatin A receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0411 0.0411
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0137 0.0142
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0702 0.1734
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1045 0.1045
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0702 0.1734
Schistosoma mansoni inositol monophosphatase 0.0112 0.0569 0.1406
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0411 0.0411
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0334 0.0826
Plasmodium falciparum histone acetyltransferase GCN5 0.0039 0.0118 0.4863
Brugia malayi CXXC zinc finger family protein 0.0031 0.0072 0.0257
Plasmodium vivax SET domain protein, putative 0.006 0.0248 1
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.01 0.0247
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus ubiquitin specific protease 41 0.0042 0.0137 0.0338
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0112 0.0569 0.2565
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0025 0.0035 0.0088
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0025 0.0035 0.1457
Brugia malayi putative neuropeptide receptor 0.0086 0.0411 0.1456
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi Tachykinin-like peptides receptor 99D 0.0086 0.0411 0.1456
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0411 0.1015
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0074 0.0334 0.0826
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.033 0.0816
Onchocerca volvulus 0.0086 0.0411 0.1492
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0411 0.1015
Brugia malayi Latrophilin receptor protein 2 0.0127 0.0662 0.2347
Echinococcus multilocularis neuropeptides capa receptor 0.0086 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0702 0.1734
Brugia malayi G-protein coupled receptor 0.0086 0.0411 0.1456
Leishmania major C-8 sterol isomerase-like protein 0.0365 0.2114 1
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0158 0.0852 0.3021
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0127 0.0662 0.1636
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0411 0.1456
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0134 0.0702 0.0702
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.0086 0.0411 0.1456
Echinococcus multilocularis G-protein coupled receptor, putative 0.0086 0.0411 0.0411
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0025 0.0035 0.0035
Trypanosoma brucei DNA polymerase eta, putative 0.0044 0.0151 0.0713
Trichomonas vaginalis alpha-galactosidase/alpha-N-acetylgalactosaminidase, putative 0.0074 0.0334 0.0419
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Echinococcus multilocularis GPCR, family 2 0.0127 0.0662 0.0662
Loa Loa (eye worm) G-protein coupled receptor 0.0086 0.0411 0.1456
Leishmania major trypanothione reductase 0.0046 0.0167 0.0631
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0086 0.0411 0.0411
Trypanosoma cruzi DNA polymerase eta, putative 0.0044 0.0151 0.0558
Brugia malayi GnHR receptor homolog 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0186 0.1023 0.3627
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0134 0.0702 0.2488
Brugia malayi G-protein coupled receptor 0.0086 0.0411 0.1456
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0039 0.0121 0.0569
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.0086 0.0411 0.0411
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0127 0.0662 0.2347
Echinococcus granulosus jumonji domain containing protein 0.0082 0.0385 0.0951
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.006 0.0248 0.0613
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0046 0.0165 0.0586
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Toxoplasma gondii aminopeptidase n, putative 0.0025 0.0035 0.0614
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0126
Mycobacterium tuberculosis Probable reductase 0.0106 0.0531 0.1236
Schistosoma mansoni hypothetical protein 0.0681 0.4046 1
Loa Loa (eye worm) PHD-finger family protein 0.0059 0.0244 0.0863
Schistosoma mansoni hypothetical protein 0.0127 0.0662 0.1636
Echinococcus multilocularis g-protein coupled receptor 0.0086 0.0411 0.0411
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0025 0.0035 0.0088
Loa Loa (eye worm) melatonin receptor type 1A 0.0086 0.0411 0.1456
Echinococcus multilocularis fmrfamide receptor 0.0086 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0275 0.1566 0.5553
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.0482 0.1709
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0035 0.1432
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0025 0.0035 0.0088
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) tyrosyl-DNA phosphodiesterase 0.0064 0.0274 0.0971
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Echinococcus multilocularis neuropeptide s receptor 0.0086 0.0411 0.0411
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Brugia malayi F/Y-rich N-terminus family protein 0.0031 0.0072 0.0255
Echinococcus granulosus histone acetyltransferase KAT2B 0.0139 0.0733 0.1811
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0042 0.014 0.2451
Echinococcus granulosus orexin receptor type 2 0.0086 0.0411 0.1015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0039 0.0121 0.0411
Schistosoma mansoni hypothetical protein 0.0086 0.0411 0.1015
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0134 0.0702 0.1734
Toxoplasma gondii aminopeptidase N protein 0.0025 0.0035 0.0614
Trypanosoma brucei glucosidase, putative 0.0035 0.0098 0.046
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.0086 0.0411 0.0411
Entamoeba histolytica hypothetical protein 0.0035 0.01 0.009
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Loa Loa (eye worm) hypothetical protein 0.0059 0.0244 0.0863
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0112 0.0569 0.0749
Trypanosoma brucei C-8 sterol isomerase, putative 0.0365 0.2114 1
Schistosoma mansoni biogenic amine (5HT) receptor 0.0086 0.0411 0.1015
Echinococcus granulosus survival motor neuron protein 1 0.048 0.2821 0.6972
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0025 0.0035 0.0035
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.0531 0.1236
Echinococcus multilocularis peregrin 0.0063 0.0265 0.0265
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.056 0.1383
Schistosoma mansoni biogenic amine receptor 0.0086 0.0411 0.1015
Onchocerca volvulus 0.0086 0.0411 0.1492
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0088
Brugia malayi putative neuropeptide receptor NPR1 0.0086 0.0411 0.1456
Plasmodium vivax hypothetical protein, conserved 0.0021 0.0012 0.0492
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.0086 0.0411 0.1015
Schistosoma mansoni neuropeptide receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.0086 0.0411 0.1456
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Loa Loa (eye worm) jmjC domain-containing protein 0.0122 0.0628 0.2225
Onchocerca volvulus 0.0086 0.0411 0.1492
Echinococcus multilocularis inositol monophosphatase 1 0.0112 0.0569 0.0569
Onchocerca volvulus 0.0086 0.0411 0.1492
Leishmania major DNA polymerase eta, putative 0.0031 0.0072 0.0173
Brugia malayi latrophilin 2 splice variant baaae 0.0275 0.1566 0.5553
Onchocerca volvulus 0.0086 0.0411 0.1492
Loa Loa (eye worm) inositol-1 0.0112 0.0569 0.2016
Loa Loa (eye worm) hypothetical protein 0.0074 0.0334 0.1184
Schistosoma mansoni ap endonuclease 0.0039 0.0121 0.0299
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus hypothetical protein 0.0086 0.0411 0.1015
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0029 0.0061 0.0151
Brugia malayi Dopamine receptor protein 2 0.0086 0.0411 0.1456
Entamoeba histolytica hypothetical protein 0.0035 0.01 0.009
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0088
Echinococcus granulosus serotonin receptor 0.0086 0.0411 0.1015
Echinococcus granulosus aminopeptidase N 0.0025 0.0035 0.0088
Echinococcus granulosus dro:myosuppressin receptor 0.0086 0.0411 0.1015
Onchocerca volvulus 0.0469 0.2752 1
Loa Loa (eye worm) TATA binding protein associated factor 0.0025 0.0035 0.0126
Schistosoma mansoni neuropeptide receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0057 0.023 0.0569
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0021 0.0012 0.0501
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni ap endonuclease 0.0039 0.0121 0.0299
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0411 0.0411
Echinococcus multilocularis transcription factor Dp 1 0.0037 0.0109 0.0109
Loa Loa (eye worm) glutaminase 0.0265 0.1503 0.5328
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.048 0.2821 1
Schistosoma mansoni tyrosyl-DNA phosphodiesterase 0.0064 0.0274 0.0677
Schistosoma mansoni biogenic amine receptor 0.0086 0.0411 0.1015
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0039 0.0121 0.0411
Loa Loa (eye worm) transcription factor SMAD2 0.0116 0.0593 0.2102
Mycobacterium ulcerans glutaminase 0.0265 0.1503 0.4316
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0126
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0035 0.0098 0.0088
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0039 0.0121 0.4966
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0035 0.0165
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0411 0.1456
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0035 0.0098 0.0088
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0039 0.0121 0.0429
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0193 0.1065 0.2631
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.056 0.1383
Entamoeba histolytica hypothetical protein 0.0035 0.01 0.009
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0165 0.0165
Echinococcus granulosus dna polymerase eta 0.0044 0.0151 0.0374
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Loa Loa (eye worm) hypothetical protein 0.0365 0.2114 0.7495
Echinococcus multilocularis somatostatin receptor 0.0086 0.0411 0.0411
Brugia malayi hypothetical protein 0.0025 0.0035 0.0126
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.0086 0.0411 0.1015
Schistosoma mansoni histamine h1 receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0086 0.0411 0.0411
Echinococcus granulosus fmrfamide receptor 0.0086 0.0411 0.1015
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0039 0.0121 0.0251
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0411 0.1015
Schistosoma mansoni opsin-like receptor 0.0086 0.0411 0.1015
Echinococcus granulosus lysine specific demethylase 5A 0.0073 0.033 0.0816
Loa Loa (eye worm) hypothetical protein 0.0101 0.0501 0.1777
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus granulosus g protein coupled receptor 0.0086 0.0411 0.1015
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.0086 0.0411 0.1015
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0025 0.0035 0.0088
Loa Loa (eye worm) hypothetical protein 0.0127 0.0662 0.2347
Schistosoma mansoni neuropeptide F-like receptor 0.0086 0.0411 0.1015
Giardia lamblia Fructose-bisphosphate aldolase 0.1189 0.7156 1
Trichomonas vaginalis ap endonuclease, putative 0.0039 0.0121 0.012
Schistosoma mansoni neuropeptide receptor 0.0086 0.0411 0.1015
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0205 0.0505
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0042 0.0137 0.0338
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi AF-10 protein 0.0019 0.0001 0.0002
Brugia malayi ERG2 and Sigma1 receptor like protein 0.0365 0.2114 0.7495
Trypanosoma cruzi C-8 sterol isomerase, putative 0.0365 0.2114 1
Onchocerca volvulus 0.0086 0.0411 0.1492
Brugia malayi neuropeptide F receptor 0.0086 0.0411 0.1456
Loa Loa (eye worm) latrophilin receptor protein 2 0.0127 0.0662 0.2347
Schistosoma mansoni alpha-glucosidase 0.0136 0.0717 0.1772
Onchocerca volvulus 0.0086 0.0411 0.1492
Onchocerca volvulus 0.0086 0.0411 0.1492
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0167 0.0412
Echinococcus granulosus histone acetyltransferase KAT2B 0.0042 0.014 0.0346
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0042 0.0137 0.0142
Brugia malayi hypothetical protein 0.0216 0.1205 0.4271
Leishmania major tyrosyl-DNA phosphodiesterase 1 0.0064 0.0274 0.1147
Echinococcus multilocularis tyrosyl DNA phosphodiesterase 1 0.0064 0.0274 0.0274
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Trypanosoma cruzi tyrosyl-DNA Phosphodiesterase (Tdp1), putative 0.0064 0.0274 0.1147
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni cpg binding protein 0.0031 0.0072 0.0179
Schistosoma mansoni hypothetical protein 0.0035 0.01 0.0247
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.0086 0.0411 0.1015
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.0086 0.0411 0.1015
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0118 0.0603 0.1454
Echinococcus multilocularis aminopeptidase N 0.0025 0.0035 0.0035
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.0531 0.0115
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.0086 0.0411 0.0411
Brugia malayi neuropeptide F receptor 0.0086 0.0411 0.1456
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0039 0.0121 0.0121
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Plasmodium falciparum glutathione reductase 0.0046 0.0167 0.6847
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.0531 0.1236
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Schistosoma mansoni adenoreceptor 0.0086 0.0411 0.1015
Echinococcus multilocularis rhodopsin orphan GPCR 0.0086 0.0411 0.0411
Brugia malayi jmjC domain containing protein 0.0193 0.1065 0.3774
Echinococcus multilocularis neutral alpha glucosidase AB 0.0035 0.0098 0.0098
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0053 0.0205 0.0725
Brugia malayi Dopamine receptor protein 1 0.0086 0.0411 0.1456
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0403 0.2346 0.8316
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0205 0.0505
Entamoeba histolytica hypothetical protein 0.0035 0.01 0.009
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi MH2 domain containing protein 0.0116 0.0593 0.2102
Brugia malayi PHD-finger family protein 0.0059 0.0244 0.0863
Toxoplasma gondii thioredoxin reductase 0.0046 0.0167 0.2924
Onchocerca volvulus 0.0025 0.0035 0.0129
Echinococcus granulosus neutral alpha glucosidase AB 0.0035 0.0098 0.0242
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni hypothetical protein 0.0681 0.4046 1
Echinococcus multilocularis Glycoside hydrolase, family 27 0.0111 0.056 0.056
Schistosoma mansoni jumonji/arid domain-containing protein 0.0073 0.033 0.0816
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0411 0.0411
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.0086 0.0411 0.1015
Brugia malayi Unidentified vitellogenin-linked transcript protein 6, putative 0.0086 0.0411 0.1456
Echinococcus multilocularis survival motor neuron protein 1 0.048 0.2821 0.2821
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0165 0.0409
Onchocerca volvulus 0.0086 0.0411 0.1492
Schistosoma mansoni DNA polymerase eta 0.0044 0.0151 0.0374
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0042 0.0137 0.0142
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi Glycosyl hydrolases family 31 protein 0.0158 0.0852 0.3021
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.006 0.0248 0.0248
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0137 0.0338
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Echinococcus multilocularis alpha 1A adrenergic receptor 0.0086 0.0411 0.0411
Brugia malayi Pre-SET motif family protein 0.006 0.0248 0.0879
Leishmania major DNA polymerase eta, putative 0.0044 0.0151 0.0558
Schistosoma mansoni growth hormone secretagogue receptor 0.0086 0.0411 0.1015
Echinococcus granulosus neuropeptide receptor A26 0.0086 0.0411 0.1015
Toxoplasma gondii PHD-finger domain-containing protein 0.0059 0.0244 0.4276
Echinococcus granulosus neuropeptide receptor 0.0086 0.0411 0.1015
Leishmania major alpha glucosidase II subunit, putative 0.0035 0.0098 0.03
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi hypothetical protein 0.0025 0.0035 0.0126
Schistosoma mansoni microtubule-associated protein tau 0.0671 0.3989 0.9857
Schistosoma mansoni hypothetical protein 0.0059 0.0244 0.0602
Echinococcus multilocularis Alpha N acetylgalactosaminidase 0.0111 0.056 0.056
Loa Loa (eye worm) MH2 domain-containing protein 0.0116 0.0593 0.2102
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0059 0.0244 0.0602
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0165 0.0409
Echinococcus multilocularis neuropeptide receptor 0.0086 0.0411 0.0411
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.0086 0.0411 0.0411
Echinococcus granulosus Alpha N acetylgalactosaminidase 0.0111 0.056 0.1383
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.01 0.01
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0039 0.0121 0.0411
Brugia malayi mbt repeat family protein 0.0046 0.0165 0.0586
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0025 0.0035 0.1432
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0581 0.3436 1
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0411 0.1015
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.006 0.0248 0.0613
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0205 0.0205
Onchocerca volvulus 0.0031 0.0072 0.0263
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Schistosoma mansoni lipoxygenase 0.008 0.0373 0.0922
Onchocerca volvulus 0.0092 0.0443 0.1611
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi Dopamine receptor 0.0086 0.0411 0.1456
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0127 0.0662 0.0662
Trichomonas vaginalis inositol monophosphatase, putative 0.0112 0.0569 0.0749
Entamoeba histolytica tyrosyl-DNA phosphodiesterase, putative 0.0064 0.0274 0.0335
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.0086 0.0411 0.0411
Onchocerca volvulus Alhambra homolog 0.0059 0.0244 0.0885
Loa Loa (eye worm) hypothetical protein 0.0025 0.0035 0.0126
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.0086 0.0411 0.1015
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0411 0.1015
Schistosoma mansoni cpg binding protein 0.0033 0.0083 0.0206
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Echinococcus multilocularis g protein coupled receptor 0.0086 0.0411 0.0411
Echinococcus multilocularis tachykinin peptides receptor 99D 0.0086 0.0411 0.0411
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.0531 0.1236
Schistosoma mansoni biogenic amine (dopamine) receptor 0.0086 0.0411 0.1015
Onchocerca volvulus 0.0086 0.0411 0.1492
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0068 0.0299 0.0738
Loa Loa (eye worm) leukotriene A4 hydrolase 0.047 0.2759 0.9779
Echinococcus granulosus cpg binding protein 0.0033 0.0083 0.0206
Loa Loa (eye worm) aminopeptidase N 0.0025 0.0035 0.0126
Echinococcus granulosus peptide allatostatin:somatostatin 0.0086 0.0411 0.1015
Echinococcus granulosus histone lysine methyltransferase setb 0.006 0.0248 0.0613
Giardia lamblia PHD finger protein 15 0.0059 0.0244 0.0178
Toxoplasma gondii melibiase subfamily protein 0.0111 0.056 0.9839
Echinococcus granulosus G protein coupled receptor 139 0.0086 0.0411 0.1015
Echinococcus multilocularis lysosomal alpha glucosidase 0.0158 0.0852 0.0852
Echinococcus granulosus neuropeptide s receptor 0.0086 0.0411 0.1015
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0411 0.1015
Echinococcus granulosus biogenic amine 5HT receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) TYRA-2 protein 0.0086 0.0411 0.1456
Schistosoma mansoni alpha-galactosidase/alpha-n-acetylgalactosaminidase 0.0111 0.056 0.1383
Schistosoma mansoni hypothetical protein 0.0019 0.0001 0.0002
Trichomonas vaginalis alpha-glucosidase, putative 0.0035 0.0098 0.0088
Schistosoma mansoni inositol monophosphatase 0.0112 0.0569 0.1406
Schistosoma mansoni peptide (allatostatin)-like receptor 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.047 0.2759 0.6818
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0115 0.0584 0.1444
Onchocerca volvulus 0.0086 0.0411 0.1492
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0412 0.2404 0.8522
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0112 0.0569 1
Echinococcus granulosus dnaJ subfamily B 0.0442 0.2586 0.639
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni amine GPCR 0.0086 0.0411 0.1015
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0134 0.0702 0.1734
Toxoplasma gondii aminopeptidase N, putative 0.0025 0.0035 0.0614
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0042 0.0137 0.0488
Schistosoma mansoni opsin-like receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis leukotriene A 4 hydrolase 0.047 0.2759 0.2759
Plasmodium falciparum phd finger protein, putative 0.0059 0.0244 1
Schistosoma mansoni hypothetical protein 0.0275 0.1566 0.3871
Echinococcus multilocularis serotonin receptor 0.0086 0.0411 0.0411
Trypanosoma brucei Aminopeptidase M1, putative 0.0025 0.0035 0.0165
Trichomonas vaginalis bromodomain-containing protein, putative 0.0042 0.014 0.0147
Brugia malayi ORL1-like opioid receptor 0.0086 0.0411 0.1456
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0072 0.0257
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0042 0.0137 0.0137
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.0086 0.0411 0.1015
Trypanosoma brucei trypanothione reductase 0.0046 0.0167 0.0786
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0118 0.0603 0.0361
Brugia malayi jmjC domain containing protein 0.0073 0.033 0.1171
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0165 0.0165
Brugia malayi Tyrosyl-DNA phosphodiesterase family protein 0.0064 0.0274 0.0971
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Onchocerca volvulus 0.0086 0.0411 0.1492
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.0531 0.1236
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0403 0.2346 0.8316
Schistosoma mansoni hypothetical protein 0.0442 0.2586 0.639
Loa Loa (eye worm) neuropeptide F receptor 0.0086 0.0411 0.1456
Brugia malayi glutathione reductase 0.0046 0.0167 0.0591
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.0086 0.0411 0.1015
Echinococcus granulosus sex peptide receptor 0.0086 0.0411 0.1015
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0205 0.0725
Echinococcus multilocularis PHD finger protein rhinoceros 0.0059 0.0244 0.0244
Echinococcus granulosus neuropeptide receptor 0.0086 0.0411 0.1015
Echinococcus granulosus neuropeptide Y receptor 0.0086 0.0411 0.1015
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0167 0.0138
Brugia malayi Peptidase family M1 containing protein 0.0025 0.0035 0.0126
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.01 0.0497 0.1134
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni alpha glucosidase 0.0035 0.0098 0.0242
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0039 0.0121 0.0004
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0042 0.0137 0.0137
Echinococcus granulosus g protein coupled receptor 0.0086 0.0411 0.1015
Echinococcus multilocularis neuropeptide Y receptor 0.0086 0.0411 0.0411
Schistosoma mansoni survival motor neuron protein 0.0098 0.0482 0.1191
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0021 0.001 0.0025
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0025 0.0035 0.0165
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0025 0.0035 0.1457
Echinococcus granulosus rhodopsin orphan GPCR 0.0086 0.0411 0.1015
Schistosoma mansoni amine GPCR 0.0086 0.0411 0.1015
Trichomonas vaginalis sucrase-isomaltase, putative 0.0035 0.0098 0.0088
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0165 0.0409
Loa Loa (eye worm) glutaminase 2 0.0265 0.1503 0.5328
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0165 0.0409
Echinococcus multilocularis dna polymerase eta 0.0044 0.0151 0.0151
Brugia malayi hypothetical protein 0.0086 0.0411 0.1456
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0042 0.014 0.0147
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0581 0.3436 1
Brugia malayi mbt repeat family protein 0.0046 0.0165 0.0586
Loa Loa (eye worm) jmjC domain-containing protein 0.0073 0.033 0.1171
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0193 0.1065 0.1065
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.1189 0.7156 1
Onchocerca volvulus 0.0086 0.0411 0.1492
Onchocerca volvulus 0.0046 0.0165 0.0601
Echinococcus granulosus neuropeptides capa receptor 0.0086 0.0411 0.1015
Echinococcus granulosus 7tm_1 domain containing protein 0.0086 0.0411 0.1015
Echinococcus multilocularis cpg binding protein 0.0033 0.0083 0.0083
Brugia malayi glutaminase DH11.1 0.0265 0.1503 0.5328
Schistosoma mansoni biogenic amine receptor 0.0086 0.0411 0.1015
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.01 0.0247
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0042 0.0137 0.0488
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0042 0.0137 0.0338
Echinococcus granulosus tm gpcr rhodopsin 0.0086 0.0411 0.1015
Loa Loa (eye worm) hypothetical protein 0.0086 0.0411 0.1456
Schistosoma mansoni rhodopsin-like orphan GPCR 0.0086 0.0411 0.1015

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 20 uM Displacement of [125I]IL8 from human recombinant IL8 type A receptor ChEMBL. 10843593

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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