Detailed information for compound 1004251

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 608.723 | Formula: C37H40N2O6
  • H donors: 1 H acceptors: 0 LogP: 6.2 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 2
  • SMILES: COc1cc2CCN[C@H]3c2cc1Oc1c2c(CCN([C@H]2Cc2ccc(Oc4cc(C3)ccc4OC)cc2)C)cc(c1OC)OC
  • InChi: 1S/C37H40N2O6/c1-39-15-13-25-20-34(42-4)36(43-5)37-35(25)29(39)17-22-6-9-26(10-7-22)44-32-18-23(8-11-30(32)40-2)16-28-27-21-33(45-37)31(41-3)19-24(27)12-14-38-28/h6-11,18-21,28-29,38H,12-17H2,1-5H3/t28-,29+/m1/s1
  • InChiKey: ULYPVLZRRZENPT-WDYNHAJCSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Echinococcus granulosus hypothetical protein 0.074138 0.69492 0.69492
Onchocerca volvulus 0.0156658 0.123007 0.133276
Toxoplasma gondii hypothetical protein 0.00501151 0.0187988 0.0155319
Schistosoma mansoni protein kinase 0.00498577 0.0185471 0.0181182
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis tyrosine protein kinase Abl 0.00463533 0.0151195 0.0151195
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Schistosoma mansoni endoplasmin 0.00665461 0.0348699 0.0344481
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) hypothetical protein 0.00593846 0.0278653 0.0278653
Echinococcus multilocularis sex peptide receptor 0.00313991 0.000492846 0.000492846
Trypanosoma brucei Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.00593846 0.0278653 0.0246285
Toxoplasma gondii heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Plasmodium falciparum serine/threonine protein kinase, putative 0.105329 1 1
Echinococcus multilocularis allatostatin A receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00400992 0.00900238 0.00900238
Toxoplasma gondii ATPase/histidine kinase/DNA gyrase B/HSP90 domain-containing protein 0.00676347 0.0359346 0.0327247
Entamoeba histolytica cell division protein kinase 2, putative 0.076444 0.717475 0.716534
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis thyrotropin releasing hormone receptor 0.00313991 0.000492846 0.000492846
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.100802 0.955722 0.955574
Trypanosoma cruzi cdc2-related kinase 1 0.076444 0.717475 0.716534
Entamoeba histolytica heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus granulosus tyrosine protein kinase ABL1 0.00400992 0.00900238 0.00900238
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis twitchin 0.00330469 0.00210454 0.00210454
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus orexin receptor type 2 0.00313991 0.000492846 0.000492846
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.0138335 0.105086 0.105086
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Mycobacterium tuberculosis Hypothetical protein 0.00811611 0.0491647 0.274578
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni neuropeptide f receptor 76f 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus activin receptor type 0.00489116 0.0176217 0.0176217
Brugia malayi Endoplasmin precursor 0.00665461 0.0348699 0.034394
Echinococcus granulosus tm gpcr rhodopsin 0.00313991 0.000492846 0.000492846
Echinococcus granulosus nervana 2 0.00488937 0.0176042 0.0176042
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni atypical protein kinase C 0.00667672 0.0350861 0.0346644
Echinococcus multilocularis neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus cyclin dependent kinase 5 0.076444 0.717475 0.717475
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis rac serine:threonine kinase 0.00831818 0.0511411 0.0511411
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Onchocerca volvulus Netrin receptor homolog 0.00318236 0.000908059 0.000451687
Brugia malayi serine/threonine-protein kinase 6 0.105329 1 1
Echinococcus multilocularis neuropeptide receptor 0.00313991 0.000492846 0.000492846
Brugia malayi WGR domain containing protein 0.0345698 0.307907 0.307565
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Echinococcus granulosus serotonin receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni histamine-responsive GPCR (AAF21638) 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus growth hormone secretagogue receptor type 1 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi Heat shock protein 83, putative 0.00665461 0.0348699 0.0316564
Plasmodium falciparum protein kinase, putative 0.00489116 0.0176217 0.0143508
Entamoeba histolytica protein kinase, putative 0.105329 1 1
Schistosoma mansoni serine/threonine protein kinase 0.076444 0.717475 0.717352
Echinococcus granulosus acetylcholinesterase 0.00666991 0.0350195 0.0350195
Schistosoma mansoni myosin xvIII 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus tyrosine protein kinase HCK 0.00481023 0.0168302 0.0168302
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus pyroglutamylated rfamide peptide receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.0096002 0.0636805 0.0632188
Echinococcus granulosus titin 0.00330469 0.00210454 0.00210454
Echinococcus multilocularis neuropeptide FF receptor 2 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis protein kinase c epsilon type 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Lyn 0.010678 0.0742219 0.0742219
Mycobacterium ulcerans epoxide hydrolase EphA 0.0163569 0.129768 0.910704
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158884 0.125185 0.125185
Brugia malayi ERG2 and Sigma1 receptor like protein 0.040085 0.36185 0.361535
Echinococcus multilocularis alpha 1A adrenergic receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.076444 0.717475 0.717475
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Leishmania major hypothetical protein, conserved 0.00593846 0.0278653 0.0246285
Brugia malayi Immunoglobulin I-set domain containing protein 0.00324954 0.00156514 0.00107282
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Brugia malayi Protein kinase domain containing protein 0.0451593 0.411481 0.411191
Entamoeba histolytica protein kinase, putative 0.00481023 0.0168302 0.0135566
Schistosoma mansoni neuropeptide receptor 0.0338732 0.301093 0.300788
Echinococcus multilocularis endoplasmin 0.00455904 0.0143732 0.0143732
Schistosoma mansoni pyruvate dehydrogenase 0.013999 0.106705 0.106315
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus granulosus dihydrofolate reductase 0.0175137 0.141082 0.141082
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Onchocerca volvulus 0.097124 0.919744 1
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis cyclin dependent kinase 5 0.076444 0.717475 0.717475
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Loa Loa (eye worm) AGC/PKN protein kinase 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) TK/FAK protein kinase 0.030928 0.272286 0.272286
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Entamoeba histolytica PH domain containing protein kinase, putative 0.00831818 0.0511411 0.0479818
Loa Loa (eye worm) 5-hydroxytryptamine 2C receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis growth hormone secretagogue receptor type 1 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) TK protein kinase 0.00699077 0.0381578 0.0381578
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Trypanosoma brucei heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0133827 0.100677 0.100677
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni biogenic amine (5HT) receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus titin 0.00330469 0.00210454 0.00210454
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Echinococcus granulosus proto oncogene tyrosine protein kinase LCK 0.00761618 0.0442749 0.0442749
Brugia malayi hypothetical protein 0.00501151 0.0187988 0.018315
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.00488937 0.0176042 0.0176042
Schistosoma mansoni family S9 non-peptidase homologue (S09 family) 0.00666991 0.0350195 0.0345978
Echinococcus multilocularis g-protein coupled receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine protein kinase 0.011861 0.0857934 0.0853939
Leishmania major mitogen-activated protein kinase kinase 5, putative;with=GeneDB:LmxM36.0860 0.0109512 0.0768946 0.073821
Leishmania major protein kinase, putative 0.00489116 0.0176217 0.0143508
Echinococcus multilocularis peptide (allatostatin:somatostatin) 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Fps85D 0.00400992 0.00900238 0.00900238
Loa Loa (eye worm) hypothetical protein 0.026827 0.232174 0.232174
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Echinococcus granulosus rho-associated protein kinase 1 0.0156658 0.123007 0.123007
Toxoplasma gondii calcium dependent protein kinase CDPK8 0.00489116 0.0176217 0.0143508
Giardia lamblia Aurora kinase 0.105329 1 1
Plasmodium vivax serine/threonine protein kinase 6, putative 0.105329 1 1
Entamoeba histolytica protein kinase, putative 0.00555585 0.0241229 0.0208737
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Srms 0.00699077 0.0381578 0.0381578
Loa Loa (eye worm) AGC/DMPK/ROCK protein kinase 0.0451593 0.411481 0.411481
Schistosoma mansoni proto-oncogene tyrosine-protein kinase src 0.00463533 0.0151195 0.0146891
Onchocerca volvulus DNA ligase 3 homolog 0.00593846 0.0278653 0.0297769
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis fmrfamide receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) TKL/MLK/MLK protein kinase 0.00339001 0.00293902 0.00293902
Schistosoma mansoni serine/threonine protein kinase 0.076444 0.717475 0.717352
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Trichomonas vaginalis endoplasmin, putative 0.00454749 0.0142603 0.0109783
Trypanosoma cruzi polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Giardia lamblia Kinase, CMGC MAPK 0.100802 0.955722 0.955076
Trypanosoma brucei heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Toxoplasma gondii pyruvate dehydrogenase kinase, putative 0.0046679 0.015438 0.0121598
Leishmania major protein kinase, putative 0.105329 1 1
Echinococcus granulosus tyrosine protein kinase Btk29A 0.0181958 0.147753 0.147753
Loa Loa (eye worm) melatonin receptor type 1A 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Loa Loa (eye worm) acetylcholinesterase 1 0.00666991 0.0350195 0.0350195
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine-protein kinase 0.00831818 0.0511411 0.0507264
Plasmodium vivax protein kinase Crk2 0.076444 0.717475 0.716534
Echinococcus multilocularis sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Trypanosoma brucei cdc2-related kinase 1 0.076444 0.717475 0.716534
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0187988
Echinococcus granulosus tm gpcr rhodopsin 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Schistosoma mansoni heat shock protein 0.00665461 0.0348699 0.0344481
Echinococcus multilocularis dual specificity testis specific protein kinase 0.00489116 0.0176217 0.0176217
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Trypanosoma cruzi pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Brugia malayi protein unc-22 0.00330469 0.00210454 0.00161249
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0345698 0.307907 0.307604
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis c Jun NH2 terminal kinase 0.0265773 0.229732 0.229732
Echinococcus granulosus mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Echinococcus granulosus serine threonine protein kinase nrc 0.00795115 0.0475512 0.0475512
Echinococcus granulosus 7TM GPCR rhodopsin 0.00313991 0.000492846 0.000492846
Echinococcus granulosus uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Echinococcus granulosus heat shock protein 90 0.00455904 0.0143732 0.0143732
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00548961 0.0234751 0.0234751
Echinococcus granulosus alpha 1A adrenergic receptor 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.100802 0.955722 0.955574
Brugia malayi thymidylate synthase 0.0170604 0.136648 0.136222
Brugia malayi kinase, mitochondrial precursor 0.013999 0.106705 0.106265
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Brugia malayi hypothetical protein 0.00811611 0.0491647 0.0486959
Schistosoma mansoni serine/threonine protein kinase 0.100802 0.955722 0.955702
Brugia malayi Carboxylesterase family protein 0.00666991 0.0350195 0.0345437
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.00501151 0.0187988 0.0187988
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00699077 0.0381578 0.0381578
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0345698 0.307907 0.305602
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis nervana 2 0.00488937 0.0176042 0.0176042
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni tyrosine kinase 0.00761618 0.0442749 0.0438573
Echinococcus multilocularis rho associated protein kinase 0.0156658 0.123007 0.123007
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Loa Loa (eye worm) hypothetical protein 0.019874 0.164168 0.164168
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0104452 0.0719455 0.0719455
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.100802 0.955722 0.955574
Schistosoma mansoni serine/threonine protein kinase 0.0265773 0.229732 0.229396
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Echinococcus multilocularis tyrosine protein kinase ABL1 0.00400992 0.00900238 0.00900238
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Entamoeba histolytica protein kinase, putative 0.105329 1 1
Echinococcus multilocularis serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Echinococcus granulosus 5'partial|3'partial|mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.0733823 0.687528 0.687528
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) AGC/AKT protein kinase 0.0108122 0.0755354 0.0755354
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.00555585 0.0241229 0.0241229
Schistosoma mansoni sodium-dependent amino acid transporter 0.00501151 0.0187988 0.01837
Plasmodium vivax endoplasmin, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Loa Loa (eye worm) solute carrier family 6 member 4 0.0295223 0.258537 0.258537
Echinococcus multilocularis tyrosine protein kinase shark 0.0474233 0.433625 0.433625
Brugia malayi Protein kinase domain containing protein 0.00555585 0.0241229 0.0236418
Echinococcus granulosus aurora kinase A 0.105329 1 1
Onchocerca volvulus 0.0141093 0.107784 0.116716
Onchocerca volvulus Tankyrase homolog 0.00466613 0.0154207 0.0162391
Schistosoma mansoni serine/threonine protein kinase 0.0156658 0.123007 0.122624
Echinococcus granulosus protein kinase c iota type 0.00555585 0.0241229 0.0241229
Brugia malayi Dual specificity mitogen-activated protein kinase kinase mek-2 0.0109512 0.0768946 0.0764394
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.100802 0.955722 0.955574
Echinococcus granulosus poly adp ribose polymerase 2 0.0345698 0.307907 0.307907
Echinococcus granulosus G protein coupled 5 hydroxytryptamine receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis tyrosine protein kinase lyn lyn a protein tyrosine kinase lymphocyte specific protein tyrosine kinase 0.00761618 0.0442749 0.0442749
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Brugia malayi Variant SH3 domain containing protein 0.00339001 0.00293902 0.00244738
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Trypanosoma brucei aurora B kinase 0.105329 1 1
Echinococcus multilocularis kinase protein 0.0150659 0.11714 0.11714
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis c src tyrosine kinase 0.00463533 0.0151195 0.0151195
Plasmodium falciparum heat shock protein 90 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Trichomonas vaginalis CMGC family protein kinase 0.076444 0.717475 0.716534
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0170604 0.136648 0.965006
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Echinococcus multilocularis tyrosine protein kinase Src42A 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) unidentified vitellogenin-linked transcript protein 6 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine kinase 0.00400992 0.00900238 0.00900238
Trypanosoma brucei cdc2-related kinase 3 0.076444 0.717475 0.716534
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.00488937 0.0176042 0.0176042
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.0237568 0.202145 0.199489
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Brugia malayi Protein kinase domain containing protein 0.00600122 0.0284791 0.028
Onchocerca volvulus Serine\/threonine kinase homolog 0.0133827 0.100677 0.108985
Trypanosoma cruzi heat shock protein 90, putative 0.00420268 0.0108878 0.00759449
Trichomonas vaginalis conserved hypothetical protein 0.00811611 0.0491647 0.0459989
Echinococcus granulosus 5'partial|cyclin dependent kinase 1 0.076444 0.717475 0.717475
Echinococcus granulosus neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus 3'partial|mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Echinococcus multilocularis 7TM GPCR, rhodopsin 0.00313991 0.000492846 0.000492846
Schistosoma mansoni protein kinase 0.0109512 0.0768946 0.0764912
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi cdc2-related kinase 1 0.076444 0.717475 0.716534
Entamoeba histolytica heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Plasmodium falciparum protein kinase 5 0.076444 0.717475 0.716534
Brugia malayi WGR domain containing protein 0.0555961 0.513563 0.513323
Trypanosoma cruzi mitogen-activated protein kinase kinase 5 0.0109512 0.0768946 0.073821
Echinococcus multilocularis serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis neuropeptide receptor 0.0338732 0.301093 0.301093
Echinococcus granulosus endoplasmin 0.00455904 0.0143732 0.0143732
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) hypothetical protein 0.00666991 0.0350195 0.0350195
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.00795115 0.0475512 0.0475512
Loa Loa (eye worm) endoplasmin 0.00665461 0.0348699 0.0348699
Trypanosoma brucei rac serine-threonine kinase, putative 0.0108122 0.0755354 0.0724574
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Loa Loa (eye worm) SRC-1 0.00761618 0.0442749 0.0442749
Echinococcus granulosus cyclin dependent kinase 0.076444 0.717475 0.717475
Giardia lamblia Kinase, CMGC CDK 0.076444 0.717475 0.713355
Echinococcus multilocularis activin receptor type 0.00489116 0.0176217 0.0176217
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Brugia malayi Immunoglobulin I-set domain containing protein 0.00330469 0.00210454 0.00161249
Loa Loa (eye worm) CMGC/CDK/CDK5 protein kinase 0.076444 0.717475 0.717475
Loa Loa (eye worm) poly(ADP-ribose) polymerase 0.0247974 0.212323 0.212323
Brugia malayi P38 map kinase family protein 2 0.0158884 0.125185 0.124754
Loa Loa (eye worm) TK/ABL protein kinase 0.00400992 0.00900238 0.00900238
Plasmodium falciparum amino acid transporter, putative 0.00501151 0.0187988 0.0155319
Loa Loa (eye worm) hypothetical protein 0.013999 0.106705 0.106705
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00847933 0.0527173 0.0527173
Echinococcus granulosus poly ADP ribose polymerase 1 0.0555961 0.513563 0.513563
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Echinococcus multilocularis thymidylate synthase 0.0170604 0.136648 0.136648
Echinococcus multilocularis tachykinin peptides receptor 99D 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Echinococcus multilocularis mitogen activated protein kinase 3 0.100802 0.955722 0.955722
Brugia malayi serine/threonine kinase 12 0.105329 1 1
Echinococcus granulosus dro:myosuppressin receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis cyclin dependent kinase 0.076444 0.717475 0.717475
Echinococcus granulosus biogenic amine 5HT receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus somatostatin receptor 0.00313991 0.000492846 0.000492846
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Schistosoma mansoni sodium/chloride dependent transporter 0.00501151 0.0187988 0.01837
Entamoeba histolytica protein kinase , putative 0.105329 1 1
Loa Loa (eye worm) hypothetical protein 0.0205832 0.171104 0.171104
Schistosoma mansoni alpha-1 adrenergic receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) neuropeptide F receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.00555585 0.0241229 0.0241229
Trypanosoma cruzi aurora B kinase, putative 0.105329 1 1
Echinococcus multilocularis G protein coupled 5 hydroxytryptamine receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni biogenic amine (octopamine/dopamine) receptor 0.019874 0.164168 0.163803
Echinococcus multilocularis cyclin dependent kinase 1 0.076444 0.717475 0.717475
Brugia malayi hypothetical protein 0.00400992 0.00900238 0.00851373
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.00555585 0.0241229 0.0241229
Loa Loa (eye worm) hypothetical protein 0.019874 0.164168 0.164168
Loa Loa (eye worm) gonadotropin-releasing hormone receptor 2 0.00313991 0.000492846 0.000492846
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Echinococcus granulosus neuropeptide FF receptor 2 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis poly (ADP ribose) polymerase 1 0.0555961 0.513563 0.513563
Echinococcus multilocularis orexin receptor type 2 0.00313991 0.000492846 0.000492846
Echinococcus granulosus twitchin 0.0058412 0.026914 0.026914
Echinococcus multilocularis cyclin dependent kinase 1 0.076444 0.717475 0.717475
Leishmania major cell division protein kinase 2,cdc2-related kinase 0.076444 0.717475 0.716534
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Entamoeba histolytica cell division protein kinase 2, putative 0.076444 0.717475 0.716534
Schistosoma mansoni adenoreceptor 0.00313991 0.000492846 0.0000560604
Brugia malayi Protein kinase domain containing protein 0.030928 0.272286 0.271927
Echinococcus multilocularis neuropeptide s receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) TYRA-2 protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.013999 0.106705 0.106705
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Schistosoma mansoni tyrosine kinase 0.00463533 0.0151195 0.0146891
Echinococcus multilocularis NCK adaptor protein 0.00313418 0.00043681 0.00043681
Entamoeba histolytica poly(ADP-ribose) polymerase, putative 0.0555961 0.513563 0.511944
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.00455904 0.0143732 0.0110915
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Plasmodium vivax amine transporter, putative 0.00501151 0.0187988 0.0155319
Brugia malayi SRC-1 0.00761618 0.0442749 0.0438037
Entamoeba histolytica serine/threonine- protein kinase 6 , putative 0.105329 1 1
Brugia malayi Dihydrofolate reductase 0.0175137 0.141082 0.140659
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.0155319
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.00501151 0.0187988 0.0187988
Schistosoma mansoni tyrosine kinase 0.0178986 0.144847 0.144473
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Echinococcus multilocularis dihydrofolate reductase 0.0175137 0.141082 0.141082
Schistosoma mansoni serine/threonine protein kinase 0.00498577 0.0185471 0.0181182
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Loa Loa (eye worm) hypothetical protein 0.0345698 0.307907 0.307907
Echinococcus granulosus calcium activated potassium channel 0.00343377 0.00336708 0.00336708
Echinococcus granulosus Protein kinase C brain isozyme 0.00555585 0.0241229 0.0241229
Echinococcus granulosus mitogen activated protein kinase 3 0.100802 0.955722 0.955722
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.0175137 0.141082 1
Leishmania major developmentally regulated phosphoprotein-like protein 0.013999 0.106705 0.103731
Loa Loa (eye worm) STE/STE7/MEK1 protein kinase 0.0109512 0.0768946 0.0768946
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.00501151 0.0187988 0.0187988
Entamoeba histolytica protein kinase, putative 0.00524231 0.0210562 0.0177968
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Echinococcus multilocularis aurora kinase A 0.105329 1 1
Plasmodium vivax heat shock protein 86, putative 0.00665461 0.0348699 0.0316564
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.0175137 0.141082 1
Schistosoma mansoni sodium/chloride dependent transporter 0.0295223 0.258537 0.258213
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Trypanosoma cruzi cdc2-related kinase 3 0.076444 0.717475 0.716534
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) tnks protein 0.00466613 0.0154207 0.0154207
Trypanosoma cruzi C-8 sterol isomerase, putative 0.040085 0.36185 0.359725
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.00555585 0.0241229 0.0241229
Trypanosoma cruzi polo-like protein kinase, putative 0.0133827 0.100677 0.0976826
Loa Loa (eye worm) G-protein-linked acetylcholine receptor protein 2 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Echinococcus granulosus tyrosine protein kinase Src42A 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.100802 0.955722 0.955574
Schistosoma mansoni neuropeptide receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.00555585 0.0241229 0.0241229
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Echinococcus multilocularis poly (adp ribose) polymerase 2 0.0345698 0.307907 0.307907
Loa Loa (eye worm) hypothetical protein 0.0405712 0.366606 0.366606
Echinococcus granulosus thyrotropin releasing hormone receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Echinococcus granulosus tyrosine protein kinase Srms 0.00400992 0.00900238 0.00900238
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00847933 0.0527173 0.0527173
Loa Loa (eye worm) heat shock protein 90 0.00665461 0.0348699 0.0348699
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Schistosoma mansoni protein kinase 0.00489116 0.0176217 0.0171924
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Trypanosoma brucei poly(adp-ribose) polymerase 0.0345698 0.307907 0.305602
Echinococcus granulosus mitogen activated protein kinase 14 0.0158884 0.125185 0.125185
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.00795115 0.0475512 0.04438
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus multilocularis dro:myosuppressin receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus poly (ADP ribose) polymerase 0.00977245 0.0653653 0.0653653
Trichomonas vaginalis CAMK family protein kinase 0.00802718 0.0482948 0.0451261
Onchocerca volvulus 0.0170604 0.136648 0.148115
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.0096002 0.0636805 0.0687381
Trypanosoma brucei polo-like protein kinase 0.0133827 0.100677 0.0976826
Schistosoma mansoni growth hormone secretagogue receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus serotonin transporter 0.0295223 0.258537 0.258537
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) CMGC/CDK/CDC2 protein kinase 0.076444 0.717475 0.717475
Echinococcus granulosus Pyruvate dehydrogenase lipoamide kinase 0.013999 0.106705 0.106705
Loa Loa (eye worm) follicle stimulating hormone receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tankyrase 0.00466613 0.0154207 0.0154207
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus protein kinase C gamma type 0.00555585 0.0241229 0.0241229
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni histamine h1 receptor 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus serine/threonine protein kinase 0.00831818 0.0511411 0.0511411
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) thymidylate synthase 0.0170604 0.136648 0.136648
Entamoeba histolytica protein kinase domain containing protein 0.00489116 0.0176217 0.0143508
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0158884 0.125185 0.125185
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.00501151 0.0187988 0.0187988
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Brugia malayi Protein kinase domain containing protein 0.0108122 0.0755354 0.0750796
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0115638 0.0828867 0.0828867
Schistosoma mansoni tyrosine kinase 0.00761618 0.0442749 0.0438573
Loa Loa (eye worm) G-protein coupled receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0150659 0.11714 0.11714
Echinococcus granulosus peptide allatostatin:somatostatin 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase lyn tyrosine protein kinase blk 0.00761618 0.0442749 0.0442749
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus serine:threonine protein kinase 12 B 0.105329 1 1
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.00501151 0.0187988 0.0187988
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00330469 0.00210454 0.00210454
Echinococcus multilocularis tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Brugia malayi protein kinase C II. 0.00555585 0.0241229 0.0236418
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.100802 0.955722 0.955722
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Entamoeba histolytica PH domain containing protein kinase, putative 0.00831818 0.0511411 0.0479818
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus biogenic amine 5HT receptor 0.0409826 0.370629 0.370629
Entamoeba histolytica SH2-protein kinase domain containing protein 0.00524231 0.0210562 0.0177968
Trichomonas vaginalis AGC family protein kinase 0.00555585 0.0241229 0.0208737
Echinococcus multilocularis heat shock protein 90 0.00455904 0.0143732 0.0143732
Loa Loa (eye worm) TK protein kinase 0.00481023 0.0168302 0.0168302
Loa Loa (eye worm) STE/STE11/MEKK2 protein kinase 0.0096002 0.0636805 0.0636805
Schistosoma mansoni titin 0.00330469 0.00210454 0.00166846
Trichomonas vaginalis AGC family protein kinase 0.105329 1 1
Echinococcus granulosus heat shock protein 90 0.00665461 0.0348699 0.0348699
Loa Loa (eye worm) serotonin transporter b 0.0295223 0.258537 0.258537
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis STE family protein kinase 0.0109512 0.0768946 0.073821
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) CAMK/MLCK protein kinase 0.00361478 0.00513756 0.00513756
Echinococcus multilocularis mitogen activated protein kinase 0.100802 0.955722 0.955722
Trypanosoma brucei developmentally regulated phosphoprotein 0.013999 0.106705 0.103731
Schistosoma mansoni neuropeptide F-like receptor 0.00313991 0.000492846 0.0000560604
Trypanosoma brucei protein kinase, putative 0.100802 0.955722 0.955574
Echinococcus multilocularis carboxylesterase 5A 0.00666991 0.0350195 0.0350195
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0555961 0.513563 0.513351
Giardia lamblia Kinase, CMGC CDK 0.076444 0.717475 0.713355
Loa Loa (eye worm) TKL/MLK/TAK1 protein kinase 0.0138335 0.105086 0.105086
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0133827 0.100677 0.100677
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus thymidylate synthase 0.0170604 0.136648 0.136648
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.00811611 0.0491647 0.0459989
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Treponema pallidum sodium- and chloride- dependent transporter 0.0295223 0.258537 1
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Leishmania major dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Echinococcus multilocularis proto oncogene tyrosine protein kinase LCK 0.00761618 0.0442749 0.0442749
Echinococcus granulosus tyrosine kinase 0.00400992 0.00900238 0.00900238
Toxoplasma gondii poly(ADP-ribose) polymerase catalytic domain-containing protein 0.0573075 0.530302 0.528738
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Entamoeba histolytica protein kinase domain containing protein 0.105329 1 1
Echinococcus granulosus tyrosine protein kinase Blk 0.00699077 0.0381578 0.0381578
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.00795115 0.0475512 0.0475512
Echinococcus granulosus G protein coupled receptor 139 0.00313991 0.000492846 0.000492846
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0133827 0.100677 0.100677
Leishmania major DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Brugia malayi Carboxylesterase family protein 0.00666991 0.0350195 0.0345437
Schistosoma mansoni tyrosine kinase 0.00463533 0.0151195 0.0146891
Echinococcus granulosus growth factor receptor bound protein 2 0.00313418 0.00043681 0.00043681
Echinococcus multilocularis tyrosine protein kinase HCK 0.00481023 0.0168302 0.0168302
Echinococcus granulosus allatostatin A receptor 0.00313991 0.000492846 0.000492846
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus 3'partial|tyrosine protein kinase Fgr 0.00761618 0.0442749 0.0442749
Echinococcus granulosus tyrosine protein kinase shark 0.0474233 0.433625 0.433625
Loa Loa (eye worm) norepinephrine transporter 0.0295223 0.258537 0.258537
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus granulosus tyrosine protein kinase Src42A 0.00548961 0.0234751 0.0234751
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Loa Loa (eye worm) STE/STE20/KHS protein kinase 0.00498577 0.0185471 0.0185471
Brugia malayi Protein kinase domain containing protein 0.076444 0.717475 0.717336
Trypanosoma cruzi Poly(ADP-ribose) polymerase and DNA-Ligase Zn-finger region/Zinc-finger (CX5CX6HX5H) motif containing protein, putative 0.00593846 0.0278653 0.0246285
Trypanosoma brucei DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Echinococcus multilocularis serotonin receptor 0.00313991 0.000492846 0.000492846
Entamoeba histolytica SH2-protein kinase domain containing protein 0.00400992 0.00900238 0.0057028
Loa Loa (eye worm) CMGC/MAPK/JNK protein kinase 0.0265773 0.229732 0.229732
Echinococcus granulosus mitogen activated protein kinase kinase kinase 0.00498577 0.0185471 0.0185471
Echinococcus multilocularis Glutaredoxin protein 5 0.00488937 0.0176042 0.0176042
Echinococcus multilocularis kinase protein 0.0150659 0.11714 0.11714
Loa Loa (eye worm) IKK protein kinase 0.097124 0.919744 0.919744
Schistosoma mansoni ancient conserved domain protein 2 (cyclin m2) 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.00666991 0.0350195 0.0350195
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Brugia malayi serine/threonine protein kinase 6 0.105329 1 1
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.00555585 0.0241229 0.0241229
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) carboxylesterase 0.00666991 0.0350195 0.0350195
Echinococcus granulosus dual specificity testis-specific protein kinase 0.00489116 0.0176217 0.0176217
Schistosoma mansoni biogenic amine (5HT) receptor 0.0409826 0.370629 0.370354
Echinococcus granulosus g protein linked acetylcholine receptor gar 2a 0.00313991 0.000492846 0.000492846
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Mycobacterium tuberculosis Probable epoxide hydrolase EphA (epoxide hydratase) (arene-oxide hydratase) 0.0163569 0.129768 0.910704
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Onchocerca volvulus Tyrosine kinase homolog 0.0161816 0.128053 0.138765
Schistosoma mansoni biogenic amine receptor 0.00313991 0.000492846 0.0000560604
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.100802 0.955722 0.955574
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.00455904 0.0143732 0.0143732
Schistosoma mansoni peptide (FMRFamide/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Brugia malayi protein-tyrosine kinase 0.00699077 0.0381578 0.0376835
Trypanosoma brucei mitogen-activated protein kinase kinase 5 0.0109512 0.0768946 0.073821
Echinococcus multilocularis tyrosine protein kinase Btk29A 0.0181958 0.147753 0.147753
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Toxoplasma gondii cell-cycle-associated protein kinase CDK, putative 0.076444 0.717475 0.716534
Echinococcus multilocularis dual specificity mitogen activated protein 0.0109512 0.0768946 0.0768946
Echinococcus multilocularis protein tyrosine kinase 0.0305588 0.268675 0.268675
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Schistosoma mansoni tankyrase 0.00466613 0.0154207 0.0149904
Plasmodium vivax hypothetical protein, conserved 0.00501151 0.0187988 0.0155319
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Schistosoma mansoni serine/threonine protein kinase 0.105329 1 1
Brugia malayi Serotonin/octopamine receptor family protein 7 0.019874 0.164168 0.163756
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.100802 0.955722 0.955574
Echinococcus multilocularis tyrosine protein kinase Fps85D 0.00400992 0.00900238 0.00900238
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0158884 0.125185 0.122272
Echinococcus multilocularis heat shock protein 0.00665461 0.0348699 0.0348699
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis poly (ADP ribose) polymerase 0.0144386 0.111004 0.111004
Trypanosoma cruzi Protein kinase B 0.00831818 0.0511411 0.0479818
Trypanosoma brucei STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Echinococcus granulosus tm gpcr rhodopsin 0.0883376 0.833805 0.833805
Echinococcus multilocularis acetylcholinesterase 0.00666991 0.0350195 0.0350195
Echinococcus multilocularis somatostatin receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.00400992 0.00900238 0.00925702
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni kinase 0.00841731 0.0521107 0.0516965
Echinococcus multilocularis neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Leishmania major pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Trypanosoma brucei protein kinase, putative 0.00489116 0.0176217 0.0143508
Trypanosoma cruzi heat shock protein 85, putative 0.00455904 0.0143732 0.0110915
Entamoeba histolytica protein kinase, putative 0.0108122 0.0755354 0.0724574
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus multilocularis serine:threonine protein kinase MRCK beta 0.00498577 0.0185471 0.0185471
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) G-protein coupled receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Trichomonas vaginalis CAMK family protein kinase 0.00802718 0.0482948 0.0451261
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Entamoeba histolytica hypothetical protein 0.00977245 0.0653653 0.0622533
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Schistosoma mansoni tyrosine kinase 0.0474233 0.433625 0.433377
Giardia lamblia Kinase, PLK 0.0133827 0.100677 0.0875623
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0295223 0.258537 0.258172
Echinococcus multilocularis serotonin transporter 0.0295223 0.258537 0.258537
Echinococcus multilocularis serine threonine protein kinase 0.00555585 0.0241229 0.0241229
Echinococcus granulosus acetylcholinesterase 0.00666991 0.0350195 0.0350195
Brugia malayi serine/threonine-protein kinase plk-2 0.0133827 0.100677 0.100234
Trypanosoma brucei Heat shock protein 83, putative 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) neuropeptide F receptor 0.00313991 0.000492846 0.000492846
Giardia lamblia Kinase, AGC PKA 0.00795115 0.0475512 0.0336618
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus granulosus neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Brugia malayi SH2 domain containing protein 0.00400992 0.00900238 0.00851373
Giardia lamblia Kinase, STE STE20 0.0109512 0.0768946 0.0634331
Echinococcus granulosus Serine/threonine-protein kinase Genghis Khan 0.00498577 0.0185471 0.0185471
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.0237568 0.202145 0.199489
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Entamoeba histolytica protein kinase 2, putative 0.00795115 0.0475512 0.04438
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Entamoeba histolytica zinc finger protein, putative 0.00466613 0.0154207 0.0121425
Schistosoma mansoni peptide (allatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus neuropeptide receptor 0.0338732 0.301093 0.301093
Echinococcus granulosus neuropeptide receptor A26 0.00313991 0.000492846 0.000492846
Echinococcus granulosus g protein coupled receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.0138335 0.105086 0.104645
Schistosoma mansoni peptide (allatostatin/somatostatin)-like receptor 0.00313991 0.000492846 0.0000560604
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.00455904 0.0143732 0.5
Brugia malayi MAP kinase sur-1 0.100802 0.955722 0.9557
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 0.0138335 0.105086 0.105086
Loa Loa (eye worm) hypothetical protein 0.040085 0.36185 0.36185
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis tyrosine protein kinase Fgr 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.0883376 0.833805 0.833805
Echinococcus multilocularis nervana 2 0.00488937 0.0176042 0.0176042
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Echinococcus granulosus protein kinase c epsilon type 0.00555585 0.0241229 0.0241229
Brugia malayi probable protein kinase 0.00498577 0.0185471 0.0180632
Schistosoma mansoni heat shock protein 0.00665461 0.0348699 0.0344481
Entamoeba histolytica serine/threonine protein kinase 6, putative 0.105329 1 1
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00501151 0.0187988 0.01837
Trypanosoma cruzi heat shock protein 85, putative 0.00665461 0.0348699 0.0316564
Brugia malayi Immunoglobulin I-set domain containing protein 0.0187853 0.153519 0.153102
Trypanosoma brucei pyruvate dehydrogenase (lipoamide) kinase, putative 0.0046679 0.015438 0.0121598
Schistosoma mansoni serine/threonine protein kinase 0.00498577 0.0185471 0.0181182
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Echinococcus granulosus heat shock protein 0.00665461 0.0348699 0.0348699
Echinococcus multilocularis fmrfamide receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus c-Jun N-terminal kinases 0.0265773 0.229732 0.229732
Schistosoma mansoni thyrotropin-releasing hormone receptor 0.00313991 0.000492846 0.0000560604
Onchocerca volvulus 0.00368719 0.00584573 0.00582309
Echinococcus granulosus netrin receptor unc 5 0.00324954 0.00156514 0.00156514
Plasmodium falciparum endoplasmin, putative 0.00454749 0.0142603 0.0109783
Mycobacterium ulcerans thymidylate synthase 0.0170604 0.136648 0.965006
Trichomonas vaginalis heat shock protein, putative 0.00455904 0.0143732 0.0110915
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis tankyrase 0.00466613 0.0154207 0.0154207
Echinococcus multilocularis acetylcholinesterase 0.00666991 0.0350195 0.0350195
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi Protein kinase domain containing protein 0.097124 0.919744 0.919705
Schistosoma mansoni neuropeptide F-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus tyrosine kinase|tyrosine protein kinase Fyn 0.00699077 0.0381578 0.0381578
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Toxoplasma gondii hypothetical protein 0.00501151 0.0187988 0.0155319
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Loa Loa (eye worm) TK/KIN16 protein kinase 0.0187853 0.153519 0.153519
Schistosoma mansoni netrin receptor unc5 0.00324954 0.00156514 0.00112882
Entamoeba histolytica protein kinase, putative 0.0108122 0.0755354 0.0724574
Echinococcus granulosus carboxylesterase 5A 0.00666991 0.0350195 0.0350195
Trypanosoma cruzi heat shock protein 90, putative 0.00665461 0.0348699 0.0316564
Brugia malayi cell division control protein 2 homolog 0.076444 0.717475 0.717336
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Echinococcus multilocularis pyroglutamylated rfamide peptide receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus g-protein coupled receptor 0.00313991 0.000492846 0.000492846
Entamoeba histolytica serine/threonine protein kinase, putative 0.0133827 0.100677 0.0976826
Schistosoma mansoni biogenic amine (dopamine) receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Trichomonas vaginalis heat shock protein, putative 0.00665461 0.0348699 0.0316564
Trichomonas vaginalis heat shock protein, putative 0.00454749 0.0142603 0.0109783
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni protein kinase 0.00498577 0.0185471 0.0181182
Echinococcus multilocularis heat shock protein 90 0.00665461 0.0348699 0.0348699
Entamoeba histolytica serine/threonine- protein kinase 6, putative 0.105329 1 1
Brugia malayi Tyrosine-protein kinase abl-1 0.00463533 0.0151195 0.0146339
Brugia malayi Sodium:neurotransmitter symporter family protein 0.00501151 0.0187988 0.018315
Brugia malayi Protein kinase domain containing protein 0.00400992 0.00900238 0.00851373
Schistosoma mansoni serine/threonine protein kinase 0.00330469 0.00210454 0.00166846
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.00501151 0.0187988 0.01837
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Echinococcus multilocularis tm gpcr rhodopsin gpcr rhodopsin superfamily 0.00313991 0.000492846 0.000492846
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.00555585 0.0241229 0.0241229
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Echinococcus multilocularis neuropeptide Y receptor 0.00313991 0.000492846 0.000492846
Entamoeba histolytica protein kinase, putative 0.0104452 0.0719455 0.0688555
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus mitogen-activated protein kinase kinase kinase 9 0.0115638 0.0828867 0.0828867
Echinococcus multilocularis titin 0.00330469 0.00210454 0.00210454
Onchocerca volvulus 0.00330469 0.00210454 0.00175327
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus poly (ADP ribose) polymerase 0.0195449 0.160949 0.160949
Echinococcus granulosus serine:threonine protein kinase N2 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Echinococcus granulosus NDR protein kinase 0.00555585 0.0241229 0.0241229
Schistosoma mansoni serine/threonine kinase 0.00555585 0.0241229 0.0236965
Schistosoma mansoni dihydrofolate reductase 0.0175137 0.141082 0.140707
Loa Loa (eye worm) dihydrofolate reductase 0.0175137 0.141082 0.141082
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Onchocerca volvulus 0.00501151 0.0187988 0.019914
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.0295223 0.258537 0.280712
Echinococcus granulosus tyrosine protein kinase Fyn 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) CAMK protein kinase 0.00330469 0.00210454 0.00210454
Plasmodium falciparum transporter, putative 0.00501151 0.0187988 0.0155319
Schistosoma mansoni tyrosine kinase 0.0452427 0.412297 0.412041
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.00501151 0.0187988 0.018315
Trichomonas vaginalis AGC family protein kinase 0.00592288 0.0277128 0.0244756
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni hypothetical protein 0.00313991 0.000492846 0.0000560604
Schistosoma mansoni pyruvate dehydrogenase 0.0119034 0.0862084 0.0858091
Giardia lamblia Heat shock protein HSP 90-alpha 0.00665461 0.0348699 0.0207955
Schistosoma mansoni serine/threonine protein kinase 0.0133827 0.100677 0.100284
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Echinococcus granulosus mitogen activated protein kinase 0.100802 0.955722 0.955722
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00795115 0.0475512 0.04438
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Brugia malayi heat shock protein 90 0.00665461 0.0348699 0.034394
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.00795115 0.0475512 0.04438
Brugia malayi Tnks protein 0.00466613 0.0154207 0.0149352
Schistosoma mansoni muscarinic acetylcholine (GAR) receptor 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis mitogen activated protein kinase 11 0.0158884 0.125185 0.125185
Echinococcus multilocularis Pyruvate dehydrogenase (lipoamide) kinase 0.013999 0.106705 0.106705
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Loa Loa (eye worm) hypothetical protein 0.0295223 0.258537 0.258537
Echinococcus multilocularis neuropeptide receptor A26 0.00313991 0.000492846 0.000492846
Schistosoma mansoni endoplasmin 0.00665461 0.0348699 0.0344481
Trypanosoma cruzi developmentally regulated phosphoprotein, putative 0.013999 0.106705 0.103731
Trypanosoma cruzi DNA repair protein, putative 0.00593846 0.0278653 0.0246285
Echinococcus granulosus neuropeptide receptor 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) AUR protein kinase 0.105329 1 1
Entamoeba histolytica hypothetical protein 0.00466613 0.0154207 0.0121425
Loa Loa (eye worm) AGC/PKC/IOTA protein kinase 0.00418264 0.0106918 0.0106918
Echinococcus multilocularis mitogen activated protein kinase 14 0.0158884 0.125185 0.125185
Echinococcus granulosus sex peptide receptor 0.00313991 0.000492846 0.000492846
Brugia malayi Stress-activated protein kinase jnk-1 0.0265773 0.229732 0.229353
Echinococcus granulosus dual specificity mitogen activated protein 0.0109512 0.0768946 0.0768946
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis tyrosine protein kinase Src64B 0.00761618 0.0442749 0.0442749
Echinococcus multilocularis conserved hypothetical protein 0.0709981 0.664208 0.664208
Trypanosoma brucei C-8 sterol isomerase, putative 0.040085 0.36185 0.359725
Echinococcus multilocularis serine:threonine protein kinase 38 0.00555585 0.0241229 0.0241229
Brugia malayi p70 ribosomal S6 kinase beta 0.0104452 0.0719455 0.0714879
Brugia malayi Protein kinase domain containing protein 0.00555585 0.0241229 0.0236418
Trypanosoma cruzi heat shock protein 90, putative 0.00455904 0.0143732 0.0110915
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Schistosoma mansoni tyrosine kinase 0.0305588 0.268675 0.268355
Trypanosoma cruzi poly(ADP-ribose) polymerase, putative 0.0345698 0.307907 0.305602
Trichomonas vaginalis conserved hypothetical protein 0.00466613 0.0154207 0.0121425
Echinococcus multilocularis calcium activated potassium channel 0.00343377 0.00336708 0.00336708
Echinococcus granulosus tyrosine kinase 0.00699077 0.0381578 0.0381578
Trypanosoma cruzi rac serine-threonine kinase, putative 0.00831818 0.0511411 0.0479818
Echinococcus multilocularis serine:threonine protein kinase 12 B 0.105329 1 1
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Leishmania major C-8 sterol isomerase-like protein 0.040085 0.36185 0.359725
Trichomonas vaginalis CAMK family protein kinase 0.0133827 0.100677 0.0976826
Trichomonas vaginalis CMGC family protein kinase 0.100802 0.955722 0.955574
Echinococcus multilocularis G protein coupled receptor 139 0.0338732 0.301093 0.301093
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.100802 0.955722 0.955574
Trichomonas vaginalis AGC family protein kinase 0.0108122 0.0755354 0.0724574
Echinococcus multilocularis tyrosine protein kinase Blk 0.00699077 0.0381578 0.0381578
Leishmania major cell division related protein kinase 2,cdc2-related kinase 0.076444 0.717475 0.716534
Echinococcus granulosus tyrosine protein kinase Src64B 0.00761618 0.0442749 0.0442749
Loa Loa (eye worm) AGC/NDR protein kinase 0.00555585 0.0241229 0.0241229
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.00555585 0.0241229 0.0241229
Echinococcus multilocularis g protein coupled receptor 0.00313991 0.000492846 0.000492846
Echinococcus granulosus protein tyrosine kinase 0.0305588 0.268675 0.268675
Trypanosoma cruzi cdc2-related kinase 3 0.076444 0.717475 0.716534
Schistosoma mansoni rhodopsin-like orphan GPCR 0.00313991 0.000492846 0.0000560604
Chlamydia trachomatis dihydrofolate reductase 0.0175137 0.141082 1
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0170604 0.136648 0.965006
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.0175137 0.141082 1
Echinococcus granulosus WGR domain containing protein 0.0195449 0.160949 0.160949
Echinococcus granulosus 7tm_1 domain containing protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni sodium/chloride dependent transporter 0.00807328 0.0487458 0.0483301
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0170604 0.136648 0.136271
Brugia malayi Hr1 repeat family protein 0.00555585 0.0241229 0.0236418
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.00501151 0.0187988 0.01837
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Schistosoma mansoni peptide (FMRFamide/neurokinin-3)-like receptor 0.00313991 0.000492846 0.0000560604
Brugia malayi Protein kinase domain containing protein 0.00498577 0.0185471 0.0180632
Schistosoma mansoni amine GPCR 0.00313991 0.000492846 0.0000560604
Echinococcus multilocularis netrin receptor unc 5 0.00324954 0.00156514 0.00156514
Schistosoma mansoni protein kinase 0.00847933 0.0527173 0.0523034
Echinococcus granulosus cyclin dependent kinase 1 0.076444 0.717475 0.717475
Schistosoma mansoni pyruvate dehydrogenase 0.0119034 0.0862084 0.0858091
Echinococcus multilocularis serotonin receptor 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis Protein kinase C, brain isozyme 0.00555585 0.0241229 0.0241229
Echinococcus granulosus neuropeptides capa receptor 0.00313991 0.000492846 0.000492846
Brugia malayi dihydrofolate reductase family protein 0.0175137 0.141082 0.140659
Echinococcus multilocularis sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Schistosoma mansoni serine/threonine-protein kinase 0.00831818 0.0511411 0.0507264
Loa Loa (eye worm) hypothetical protein 0.00555585 0.0241229 0.0241229
Echinococcus granulosus tachykinin peptides receptor 99D 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Echinococcus multilocularis mitogen activated protein kinase kinase kinase 7 0.0150659 0.11714 0.11714
Toxoplasma gondii AGC kinase 0.0104452 0.0719455 0.0688555
Echinococcus granulosus fmrfamide receptor 0.00313991 0.000492846 0.000492846
Schistosoma mansoni poly [ADP-ribose] polymerase 0.0299037 0.262268 0.261945
Echinococcus granulosus nervana 2 0.00488937 0.0176042 0.0176042
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846
Trypanosoma cruzi STE/STE11 serine/threonine-protein kinase, putative 0.00489116 0.0176217 0.0143508
Echinococcus multilocularis rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Loa Loa (eye worm) hypothetical protein 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) TK/FER protein kinase 0.00400992 0.00900238 0.00900238
Schistosoma mansoni serine/threonine protein kinase 0.00330469 0.00210454 0.00166846
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0158884 0.125185 0.122272
Schistosoma mansoni protein kinase 0.105329 1 1
Trypanosoma brucei heat shock protein, putative 0.00665461 0.0348699 0.0316564
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.00555585 0.0241229 0.0241229
Schistosoma mansoni serine/threonine protein kinase 0.00555585 0.0241229 0.0236965
Echinococcus granulosus c src tyrosine kinase 0.00463533 0.0151195 0.0151195
Toxoplasma gondii heat shock protein HSP90 0.00665461 0.0348699 0.0316564
Leishmania major heat shock protein 83-1 0.00665461 0.0348699 0.0316564
Echinococcus granulosus rhodopsin orphan GPCR 0.00313991 0.000492846 0.000492846
Onchocerca volvulus 0.012604 0.0930604 0.100699
Echinococcus granulosus Glutaredoxin protein 5 0.00488937 0.0176042 0.0176042
Echinococcus granulosus neuropeptide s receptor 0.00313991 0.000492846 0.000492846
Brugia malayi SH2 domain containing protein 0.00400992 0.00900238 0.00851373
Toxoplasma gondii aurora kinase 0.105329 1 1
Echinococcus multilocularis G-protein coupled receptor, putative 0.00313991 0.000492846 0.000492846
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.00555585 0.0241229 0.0241229
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0295223 0.258537 0.258213
Echinococcus multilocularis biogenic amine (5HT) receptor 0.0409826 0.370629 0.370629
Echinococcus multilocularis protein kinase c iota type 0.00555585 0.0241229 0.0241229
Schistosoma mansoni opsin-like receptor 0.00313991 0.000492846 0.0000560604
Echinococcus granulosus sodium and chloride dependent glycine 0.00501151 0.0187988 0.0187988
Loa Loa (eye worm) hypothetical protein 0.00313991 0.000492846 0.000492846

Activities

Activity type Activity value Assay description Source Reference
ED50 (functional) = 45.9 ng/ml Antimalarial activity after 24 hrs against chloroquine-sensitive Plasmodium falciparum D6 infected type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8450319
ED50 (functional) = 93.7 ng/ml Antimalarial activity after 24 hrs against chloroquine-resistant Plasmodium falciparum W2 infected type A+ human erythrocytes by [3H]hypoxanthine uptake ChEMBL. 8450319
ED50 (functional) = 9900 nM Cytotoxicity against human KB cells after 72 hrs by SRB assay ChEMBL. 9917283
ED50 (ADMET) = 1.2 ug ml-1 Cytotoxicity against human ZR-75-1 cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 3.5 ug ml-1 Cytotoxicity against mouse P388 cells after 2 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 3.7 ug ml-1 Cytotoxicity against human LNCAP cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 6 ug ml-1 Cytotoxicity against human KB cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 6.1 ug ml-1 Cytotoxicity against human A431 cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 7.4 ug ml-1 Cytotoxicity against human HT1080 cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
ED50 (ADMET) = 14.5 ug ml-1 Cytotoxicity against human SK-MEL-2 cells after 3 days by sulforhodamine B assay ChEMBL. 8450319
IC50 (functional) = 75 nM Antiplasmodial activity against chloroquine-sensitive Plasmodium falciparum D6 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283
IC50 (functional) = 154 nM Antiplasmodial activity against chloroquine-resistant Plasmodium falciparum W2 infected human erythrocytes as [3H]hypoxanthine uptake after 24 hrs ChEMBL. 9917283

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Plasmodium falciparum ChEMBL23 9917283

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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