Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.4903 | 0.4903 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0212 | 1 | 0.5 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.4903 | 0.4903 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0115 | 0.4903 | 0.4903 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.4903 | 0.4903 |
Brugia malayi | Putative carbonic anhydrase 5 precursor | 0.0212 | 1 | 1 |
Leishmania major | carbonic anhydrase-like protein | 0.0212 | 1 | 0.5 |
Loa Loa (eye worm) | eukaryotic-type carbonic anhydrase | 0.0212 | 1 | 1 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0212 | 1 | 1 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0023 | 0.0103 | 0.0103 |
Brugia malayi | Bromodomain containing protein | 0.0077 | 0.2945 | 0.2777 |
Schistosoma mansoni | carbonic anhydrase-related | 0.0115 | 0.4903 | 0.4903 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0829 | 0.0733 |
Toxoplasma gondii | hypothetical protein | 0.0115 | 0.4903 | 0.5 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Schistosoma mansoni | carbonic anhydrase II (carbonate dehydratase II) | 0.0212 | 1 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0037 | 0.0829 | 0.0733 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.4903 | 0.4782 |
Schistosoma mansoni | hypothetical protein | 0.0115 | 0.4903 | 0.4903 |
Trypanosoma brucei | carbonic anhydrase-like protein | 0.0212 | 1 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2116 | 0.2034 |
Echinococcus multilocularis | carbonic anhydrase II | 0.0212 | 1 | 1 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0062 | 0.2116 | 0.2034 |
Echinococcus granulosus | carbonic anhydrase II | 0.0212 | 1 | 1 |
Trypanosoma cruzi | carbonic anhydrase-like protein, putative | 0.0212 | 1 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.1089 | 0.1089 |
Schistosoma mansoni | carbonic anhydrase | 0.0115 | 0.4903 | 0.4903 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0961 | 0.0961 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.2713 | 0.2713 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.4903 | 0.4903 |
Brugia malayi | Carbonic anhydrase like protein 2 precursor | 0.0115 | 0.4903 | 0.4782 |
Loa Loa (eye worm) | hypothetical protein | 0.0115 | 0.4903 | 0.4903 |
Schistosoma mansoni | bromodomain containing protein | 0.0065 | 0.231 | 0.231 |
Loa Loa (eye worm) | carbonic anhydrase 3 | 0.0212 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0039 | 0.0957 | 0.0742 |
Echinococcus granulosus | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.4903 | 0.4782 |
Plasmodium falciparum | carbonic anhydrase | 0.0115 | 0.4903 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0044 | 0.1192 | 0.1192 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.4903 | 0.4782 |
Brugia malayi | Eukaryotic-type carbonic anhydrase family protein | 0.0115 | 0.4903 | 0.4782 |
Echinococcus multilocularis | carbonic anhydrase | 0.0115 | 0.4903 | 0.485 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | < 10 | Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutinination assay relative to galactose | ChEMBL. | 18674915 |
IC50 (binding) | = 2.5 mM | Inhibition of recombinant galectin 3 in human O type red blood cells by hemagglutinination assay | ChEMBL. | 18674915 |
IC50 (binding) | > 5 mM | Inhibition of recombinant galectin 1 in human O type red blood cells by hemagglutinination assay | ChEMBL. | 18674915 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.