Detailed information for compound 1004891

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 494.576 | Formula: C28H32F2N4O2
  • H donors: 2 H acceptors: 3 LogP: 3.8 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: OCC(N1CCC(CC1)c1c[nH]c2c1cccn2)C1CCN(CC1)C(=O)/C=C/c1cc(F)cc(c1)F
  • InChi: 1S/C28H32F2N4O2/c29-22-14-19(15-23(30)16-22)3-4-27(36)34-12-7-21(8-13-34)26(18-35)33-10-5-20(6-11-33)25-17-32-28-24(25)2-1-9-31-28/h1-4,9,14-17,20-21,26,35H,5-8,10-13,18H2,(H,31,32)/b4-3+
  • InChiKey: JWWBRTLPEUWQCU-ONEGZZNKSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens chemokine (C-C motif) receptor 2 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Toxoplasma gondii calcium dependent protein kinase CDPK7 0.0029 0.0374 0.0294
Echinococcus granulosus FERM and pleckstrin domain containing protein 0.0026 0.0296 0.0291
Toxoplasma gondii Oxysterol-binding protein 0.0026 0.0296 0.0202
Toxoplasma gondii AtPH1 family protein 0.0026 0.0296 0.0202
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Schistosoma mansoni oxysterol-binding protein 1 0.0026 0.0296 0.0376
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Loa Loa (eye worm) beta-lactamase 0.0036 0.0518 0.0546
Loa Loa (eye worm) rho-GTPase-activating 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0045
Echinococcus granulosus Pleckstrin domain containing protein family B 0.0026 0.0296 0.0291
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0736 0.0731
Echinococcus multilocularis 6 phosphofructokinase 0.0106 0.2105 0.2093
Loa Loa (eye worm) hypothetical protein 0.0385 0.8414 0.9116
Schistosoma mansoni ras GTP exchange factor 0.0014 0.0015 0.0019
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0026 0.0296 0.0306
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Loa Loa (eye worm) cytohesin 3 0.0026 0.0296 0.0306
Onchocerca volvulus Glucosylceramidase homolog 0.0167 0.348 0.4126
Echinococcus multilocularis Pleckstrin y 0.0026 0.0296 0.0282
Entamoeba histolytica ARF GTPase activating protein, putative 0.0026 0.0296 0.0306
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Brugia malayi Oxysterol binding protein 0.0026 0.0296 0.0306
Trypanosoma cruzi PH domain containing protein, putative 0.0026 0.0296 0.0452
Trichomonas vaginalis centaurin beta, putative 0.0026 0.0296 0.0306
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0221 0.0207
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Echinococcus multilocularis oxysterol binding protein 9 0.0026 0.0296 0.0282
Echinococcus granulosus beta LACTamase domain containing family member 0.0036 0.0518 0.0512
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Echinococcus multilocularis neuropeptide receptor A26 0.0455 1 1
Brugia malayi DIX domain containing protein 0.0019 0.0138 0.0133
Entamoeba histolytica PH domain containing protein 0.0026 0.0296 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Brugia malayi Dynamin 0.0026 0.0296 0.0306
Echinococcus granulosus Glutaredoxin protein 5 0.0259 0.5573 0.557
Loa Loa (eye worm) AGC/PKC/ETA protein kinase 0.0136 0.2778 0.2999
Toxoplasma gondii phosphofructokinase PFKII 0.0029 0.0357 0.0273
Brugia malayi regulator of G-protein signaling egl-10 0.0019 0.0138 0.0133
Entamoeba histolytica protein kinase, putative 0.0395 0.8641 0.9363
Brugia malayi probable spectrin beta chain 0.0026 0.0296 0.0306
Schistosoma mansoni oxysterol-binding protein 1 0.0026 0.0296 0.0376
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0829
Schistosoma mansoni rab6-interacting 0.0023 0.0221 0.0281
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.2105 0.2268
Echinococcus multilocularis Ribosomal protein S6 kinase beta 2 0.0136 0.2778 0.2767
Trichomonas vaginalis development and differentiation-enhancing factor, ddef, putative 0.0026 0.0296 0.0306
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0829
Echinococcus granulosus ras GTP exchange factor 0.0014 0.0015 0.0009
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Leishmania major hypothetical protein, conserved 0.0026 0.0296 0.087
Trichomonas vaginalis AGC family protein kinase 0.0136 0.2778 0.2999
Echinococcus multilocularis serine:threonine protein kinase N2 0.0136 0.2778 0.2767
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0106 0.2113 0.2277
Onchocerca volvulus 0.0026 0.0296 0.0335
Brugia malayi Protein kinase domain containing protein 0.0136 0.2778 0.2999
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0026 0.0296 0.0306
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0138 0.0133
Brugia malayi MAP kinase sur-1 0.0061 0.1098 0.1176
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Trichomonas vaginalis hypothetical protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Schistosoma mansoni rho gtpase activating protein 0.0026 0.0296 0.0376
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Loa Loa (eye worm) Plekhf2 protein 0.0026 0.0296 0.0306
Mycobacterium tuberculosis Probable lipase LipE 0.0036 0.0518 0.0829
Echinococcus multilocularis oxysterol binding protein 3 0.0026 0.0296 0.0282
Toxoplasma gondii hypothetical protein 0.0019 0.0138 0.0016
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0357 0.0421
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1048 0.4663
Onchocerca volvulus 0.0026 0.0296 0.0335
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0124 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Plasmodium vivax 6-phosphofructokinase, putative 0.0029 0.0357 0.0421
Onchocerca volvulus 0.0026 0.0296 0.0335
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Echinococcus granulosus type II inositol 34 bisphosphate 4 phosphatase 0.0026 0.0296 0.0291
Toxoplasma gondii AGC kinase 0.0395 0.8641 1
Mycobacterium tuberculosis Probable esterase LipL 0.0036 0.0518 0.0829
Plasmodium falciparum acylated pleckstrin-homology domain-containing protein, putative 0.0026 0.0296 0.0312
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.2105 0.2268
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0133
Schistosoma mansoni z-protein (S1r protein) 0.0019 0.0138 0.0175
Leishmania major mitogen activated protein kinase 4, putative;with=GeneDB:LmxM19.1440 0.0061 0.1098 0.4919
Echinococcus granulosus macrophage colony stimulating factor 1 receptor 0.0417 0.9134 0.9134
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus oxysterol binding protein 9 0.0026 0.0296 0.0291
Echinococcus granulosus calcium:calmodulin dependent protein kinase 0.0263 0.5651 0.5648
Echinococcus multilocularis Polycystic kidney disease protein 0.0023 0.0221 0.0207
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.0808
Schistosoma mansoni 3-hydroxyacyl-CoA dehydrogenase 0.0066 0.1199 0.1522
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0018 0.0124 0.0119
Echinococcus granulosus Arf GAP and Pleckstrin domain containing protein 0.0026 0.0296 0.0291
Echinococcus multilocularis RUN 0.0023 0.0221 0.0207
Echinococcus multilocularis dynamin 1 0.0026 0.0296 0.0282
Echinococcus multilocularis Protein kinase C, brain isozyme 0.0136 0.2778 0.2767
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0029 0.0374 0.0578
Mycobacterium ulcerans beta-lactamase 0.0036 0.0518 0.1987
Echinococcus granulosus roundabout 2 0.0015 0.0057 0.0051
Schistosoma mansoni regulator of G protein signaling 0.0019 0.0138 0.0175
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0026 0.0296 0.0306
Echinococcus granulosus ribosomal protein s6 kinase beta 1 0.0136 0.2778 0.2774
Entamoeba histolytica hypothetical protein 0.0035 0.051 0.0537
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0138 0.0123
Plasmodium falciparum calcium-dependent protein kinase 7 0.0029 0.0374 0.0453
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Echinococcus granulosus ras specific guanine nucleotide releasing factor 0.0026 0.0296 0.0291
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0034 0.047 0.0465
Entamoeba histolytica hypothetical protein 0.0035 0.051 0.0537
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Plasmodium vivax hypothetical protein, conserved 0.0026 0.0296 0.0312
Entamoeba histolytica hypothetical protein 0.0026 0.0296 0.0306
Schistosoma mansoni hypothetical protein 0.0026 0.0296 0.0376
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0546
Loa Loa (eye worm) CMGC/MAPK/ERK1 protein kinase 0.0061 0.1098 0.1176
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0263 0.5651 0.9057
Echinococcus multilocularis Ras associated and pleckstrin y 0.0026 0.0296 0.0282
Schistosoma mansoni guanyl-nucleotide exchange factor 0.0026 0.0296 0.0376
Schistosoma mansoni loxhd1 0.0023 0.0221 0.0281
Entamoeba histolytica protein kinase, putative 0.0029 0.0374 0.039
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0029 0.0374 0.0578
Brugia malayi Oxysterol-binding protein 0.0026 0.0296 0.0306
Schistosoma mansoni rhogef and pleckstrin domain protein 0.0026 0.0296 0.0376
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0106 0.2113 0.2277
Toxoplasma gondii phosphofructokinase domain-containing protein 0.0029 0.0357 0.0273
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Entamoeba histolytica protein kinase 2, putative 0.0263 0.5651 0.6117
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Schistosoma mansoni hypothetical protein 0.0026 0.0296 0.0376
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0029 0.0374 0.0578
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Echinococcus granulosus dynamin 1 0.0026 0.0296 0.0291
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Echinococcus multilocularis Rho GTPase activating protein 24 0.0026 0.0296 0.0282
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0357 0.0421
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0736 0.0934
Schistosoma mansoni hypothetical protein 0.0073 0.1353 0.1717
Loa Loa (eye worm) AGC/RSK/RSK protein kinase 0.0136 0.2778 0.2999
Echinococcus granulosus oxysterol binding protein 3 0.0026 0.0296 0.0291
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0018 0.0124 0.5
Onchocerca volvulus 0.0036 0.0518 0.0598
Plasmodium vivax oxysterol-binding protein/PH domain containing protein 0.0026 0.0296 0.0312
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0026 0.0296 0.0306
Brugia malayi follicle stimulating hormone receptor 0.0231 0.4931 0.5336
Mycobacterium ulcerans esterase/lipase LipP 0.0036 0.0518 0.1987
Brugia malayi GTPase-activator protein for Ras-like GTPase containing protein 0.0026 0.0296 0.0306
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Schistosoma mansoni hypothetical protein 0.0362 0.788 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0018 0.0124 0.0175
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0029 0.0374 0.0578
Trichomonas vaginalis serine/threonine-protein kinase sgk, putative 0.0132 0.27 0.2915
Echinococcus granulosus nervana 2 0.0259 0.5573 0.557
Loa Loa (eye worm) hypothetical protein 0.0034 0.047 0.0494
Brugia malayi GTP-ase activating protein for Arf containing protein 0.0026 0.0296 0.0306
Onchocerca volvulus 0.0036 0.0518 0.0598
Trichomonas vaginalis centaurin gamma, putative 0.0026 0.0296 0.0306
Leishmania major hypothetical protein, conserved 0.0036 0.0518 0.1987
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.1199 0.5427
Toxoplasma gondii hypothetical protein 0.0026 0.0296 0.0202
Echinococcus granulosus serine:threonine protein kinase N2 0.0136 0.2778 0.2774
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0138 0.0133
Trypanosoma cruzi serine/threonine-protein kinase NRKB, putative 0.0029 0.0374 0.0578
Schistosoma mansoni goodpasture antigen-binding protein 0.0026 0.0296 0.0376
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.1048 0.1084
Brugia malayi protein kinase C II. 0.0136 0.2778 0.2999
Echinococcus granulosus Oxysterol binding protein 11 0.0026 0.0296 0.0291
Schistosoma mansoni polycystin 1-related 0.0023 0.0221 0.0281
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0036 0.0518 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0296 0.0312
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0034 0.047 0.0456
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.0019 0.0138 0.0123
Echinococcus granulosus Pleckstrin G protein interacting region 0.0019 0.0138 0.0133
Brugia malayi latrophilin 2 splice variant baaae 0.0073 0.1353 0.1452
Echinococcus multilocularis nervana 2 0.0259 0.5573 0.5566
Trichomonas vaginalis ribosomal protein S6 kinase, 90kD, polypeptide, putative 0.0029 0.0374 0.039
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1098 0.1176
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0138 0.0123
Onchocerca volvulus 0.0036 0.0518 0.0598
Echinococcus granulosus protein kinase C gamma type 0.0136 0.2778 0.2774
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Trypanosoma cruzi PH domain containing protein, putative 0.0026 0.0296 0.0452
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0106 0.2105 1
Echinococcus multilocularis segment polarity protein dishevelled 0.0019 0.0138 0.0123
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Schistosoma mansoni hypothetical protein 0.0026 0.0296 0.0376
Onchocerca volvulus 0.0026 0.0296 0.0335
Brugia malayi Variant SH3 domain containing protein 0.0031 0.0412 0.0431
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Brugia malayi MAX-1A 0.0026 0.0296 0.0306
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0036 0.0518 0.0829
Echinococcus granulosus twitchin 0.0015 0.0049 0.0044
Toxoplasma gondii hypothetical protein 0.0026 0.0296 0.0202
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Echinococcus granulosus ribosomal protein S6 kinase alpha 3 0.0136 0.2778 0.2774
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3683 0.3982
Toxoplasma gondii protein kinase domain-containing protein 0.0029 0.0374 0.0294
Echinococcus granulosus pdz domain containing protein 0.0026 0.0296 0.0291
Trichomonas vaginalis 6-phosphofructokinase, putative 0.0029 0.0357 0.0371
Entamoeba histolytica PH domain containing protein 0.0026 0.0296 0.0306
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Trichomonas vaginalis 3-phosphoinositide dependent protein kinase-1, putative 0.0029 0.0374 0.039
Brugia malayi Variant SH3 domain containing protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0026 0.0296 0.0312
Loa Loa (eye worm) TK/KIN16 protein kinase 0.002 0.0159 0.0157
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0736 0.0934
Echinococcus multilocularis 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.1199 0.1186
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Loa Loa (eye worm) latrophilin receptor protein 2 0.0034 0.047 0.0494
Trichomonas vaginalis AGC family protein kinase 0.0136 0.2778 0.2999
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0026 0.0296 0.0306
Plasmodium falciparum RAC-beta serine/threonine protein kinase 0.0263 0.5651 1
Entamoeba histolytica protein kinase, putative 0.0136 0.2778 0.2999
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0034 0.047 0.0465
Mycobacterium tuberculosis Probable lipase LipD 0.0036 0.0518 0.0829
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Schistosoma mansoni atypical protein kinase C 0.0136 0.2778 0.3526
Echinococcus multilocularis lipoxygenase domain containing protein 0.0023 0.0221 0.0207
Plasmodium vivax hypothetical protein, conserved 0.0036 0.0518 0.0712
Echinococcus multilocularis Pleckstrin y 0.0026 0.0296 0.0282
Brugia malayi hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi Dynamin 0.0026 0.0296 0.0306
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0357 0.5
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Leishmania major serine/threonine-protein kinase a, putative 0.0029 0.0374 0.1264
Onchocerca volvulus 0.0023 0.0221 0.0246
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.2105 0.2268
Brugia malayi Immunoglobulin I-set domain containing protein 0.002 0.0159 0.0157
Echinococcus granulosus Pleckstrin y 0.0026 0.0296 0.0291
Echinococcus granulosus GRB2 associated binding protein 3 0.0026 0.0296 0.0291
Brugia malayi Latrophilin receptor protein 2 0.0034 0.047 0.0494
Onchocerca volvulus 0.0026 0.0296 0.0335
Schistosoma mansoni hypothetical protein 0.0023 0.0221 0.0281
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Onchocerca volvulus 0.0026 0.0296 0.0335
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0546
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.2105 0.2268
Echinococcus granulosus NDR protein kinase 0.0136 0.2778 0.2774
Loa Loa (eye worm) AGC/DMPK/GEK protein kinase 0.0136 0.2778 0.2999
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0228 0.4872 1
Schistosoma mansoni hypothetical protein 0.0034 0.047 0.0597
Trichomonas vaginalis protein transport protein sec7, putative 0.0026 0.0296 0.0306
Echinococcus multilocularis mitogen activated protein kinase 0.0061 0.1098 0.1085
Treponema pallidum diphosphate--fructose-6-phosphate 1-phosphotransferase 0.0029 0.0357 0.1175
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus beta 1 syntrophin 0.0026 0.0296 0.0291
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1098 0.1176
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0026 0.0296 0.0306
Echinococcus granulosus neuropeptide receptor A26 0.0455 1 1
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1098 0.1176
Leishmania major protein kinase, putative 0.0029 0.0374 0.1264
Entamoeba histolytica hypothetical protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi Doublecortin family protein 0.0023 0.0221 0.0224
Schistosoma mansoni serine/threonine kinase 0.0136 0.2778 0.3526
Loa Loa (eye worm) AGC/RSK/MSK protein kinase 0.0136 0.2778 0.2999
Trypanosoma cruzi mitogen activated protein kinase 4, putative 0.0061 0.1098 0.1741
Echinococcus granulosus son of sevenless 1 0.0014 0.0015 0.0009
Brugia malayi Protein kinase domain containing protein 0.0421 0.9228 1
Echinococcus multilocularis Oxysterol binding protein 11 0.0026 0.0296 0.0282
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0385 0.8414 1
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus arachidonate 5 lipoxygenase 0.0063 0.1143 0.1138
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0045 0.0736 0.0783
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Trichomonas vaginalis AGC family protein kinase 0.0162 0.3365 0.3636
Echinococcus multilocularis Glutaredoxin protein 5 0.0259 0.5573 0.5566
Entamoeba histolytica protein kinase, putative 0.0421 0.9228 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.1048 0.1043
Echinococcus multilocularis pdz domain containing protein 0.0026 0.0296 0.0282
Echinococcus granulosus Protein kinase C brain isozyme 0.0136 0.2778 0.2774
Loa Loa (eye worm) DIX domain-containing protein 0.0019 0.0138 0.0133
Echinococcus multilocularis pleckstrin y domain containing family A 0.0026 0.0296 0.0282
Leishmania major mitogen activated protein kinase, putative,map kinase, putative 0.0061 0.1098 0.4919
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Brugia malayi hypothetical protein 0.0019 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.0019 0.0138 0.0133
Echinococcus multilocularis ribosomal protein S6 kinase alpha 3 0.0136 0.2778 0.2767
Echinococcus granulosus 6 phosphofructokinase 0.0106 0.2105 0.2101
Onchocerca volvulus Putative neuronal RhoA GEF protein 0.0026 0.0296 0.0335
Echinococcus multilocularis collagen type iv alpha 3 binding protein 0.0026 0.0296 0.0282
Echinococcus multilocularis rac serine:threonine kinase 0.0289 0.6237 0.6232
Trypanosoma cruzi serine/threonine protein kinase, putative 0.0029 0.0374 0.0578
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.0019 0.0138 0.0133
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0657
Brugia malayi phosphofructokinase 0.0106 0.2105 0.2268
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0036 0.0518 0.0546
Giardia lamblia Pyrophosphate-fructose 6-phosphate 1-phosphotransferase alpha subunit 0.0029 0.0357 0.0421
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.1048 0.4663
Entamoeba histolytica p21-activated kinase 0.0029 0.0374 0.039
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0374 0.039
Schistosoma mansoni hypothetical protein 0.0026 0.0296 0.0376
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0036 0.0518 0.0657
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0374 0.039
Echinococcus multilocularis serine:threonine protein kinase N2 0.0136 0.2778 0.2767
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0036 0.0518 0.0829
Echinococcus multilocularis neuropeptide s receptor 0.0455 1 1
Trypanosoma cruzi Serine/threonine-protein kinase NEK21, putative 0.0029 0.0374 0.0578
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Echinococcus granulosus Pleckstrin y 0.0026 0.0296 0.0291
Loa Loa (eye worm) PH domain-containing protein 0.0026 0.0296 0.0306
Trypanosoma brucei mitogen activated protein kinase 4, putative 0.0061 0.1098 0.107
Schistosoma mansoni hypothetical protein 0.0362 0.788 1
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0034 0.047 0.0494
Loa Loa (eye worm) syntrophin-1 0.0026 0.0296 0.0306
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Schistosoma mansoni hypothetical protein 0.0034 0.047 0.0597
Trypanosoma cruzi hypothetical protein, conserved 0.0036 0.0518 0.0808
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0061 0.1099 0.1176
Trypanosoma cruzi rac serine-threonine kinase, putative 0.0289 0.6237 1
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Entamoeba histolytica hypothetical protein, conserved domain containing 0.0026 0.0296 0.0306
Brugia malayi Hr1 repeat family protein 0.0136 0.2778 0.2999
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0018 0.0124 0.0109
Plasmodium falciparum oxysterol-binding protein, putative 0.0026 0.0296 0.0312
Echinococcus multilocularis serine:threonine protein kinase 38 0.0136 0.2778 0.2767
Echinococcus granulosus Rho GTPase activating protein 24 0.0026 0.0296 0.0291
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) phosphofructokinase 0.0106 0.2105 0.2268
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0018 0.0124 0.0118
Trichomonas vaginalis esterase, putative 0.0036 0.0518 0.0546
Schistosoma mansoni development and differentiation-enhancing factor ddef 0.0026 0.0296 0.0376
Echinococcus granulosus geminin 0.0362 0.788 0.7879
Loa Loa (eye worm) oxysterol binding protein 0.0026 0.0296 0.0306
Trypanosoma cruzi Serine/threonine-protein kinase NEK17, putative 0.0029 0.0374 0.0578
Mycobacterium tuberculosis Conserved protein 0.0036 0.0518 0.0829
Trypanosoma brucei serine/threonine-protein kinase NrkA 0.0029 0.0374 0.0275
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0066 0.1199 0.5427
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0035 0.051 0.0505
Schistosoma mansoni vav2 0.0031 0.0412 0.0523
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.2105 0.2671
Echinococcus multilocularis ras specific guanine nucleotide releasing factor 0.0026 0.0296 0.0282
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Schistosoma mansoni ap endonuclease 0.0018 0.0124 0.0157
Trichomonas vaginalis centaurin alpha, putative 0.0026 0.0296 0.0306
Entamoeba histolytica protein kinase, putative 0.0029 0.0374 0.039
Plasmodium falciparum LCCL domain-containing protein 0.0023 0.0221 0.0176
Trypanosoma cruzi ADP-ribosylation factor family, putative 0.0026 0.0296 0.0452
Echinococcus multilocularis cytohesin 1 0.0026 0.0296 0.0282
Loa Loa (eye worm) hypothetical protein 0.0136 0.2778 0.2999
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Schistosoma mansoni dynamin 0.0026 0.0296 0.0376
Echinococcus granulosus rap guanine nucleotide exchange factor 6 0.0014 0.0015 0.0009
Echinococcus granulosus serine threonine protein kinase nrc 0.0263 0.5651 0.5648
Echinococcus multilocularis arf GAP with coiled coil, ANK repeat and PH 0.0026 0.0296 0.0282
Leishmania major rac serine-threonine kinase, putative,protein kinase, putative 0.0029 0.0374 0.1264
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0018 0.0124 0.0175
Trypanosoma cruzi PH domain containing protein, putative 0.0026 0.0296 0.0452
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Schistosoma mansoni dynamin 0.0026 0.0296 0.0376
Toxoplasma gondii ABC1 family protein 0.0036 0.0518 0.0462
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Brugia malayi Syntrophin-1 0.0026 0.0296 0.0306
Trichomonas vaginalis centaurin/arf, putative 0.0026 0.0296 0.0306
Mycobacterium tuberculosis Probable hydrolase 0.0036 0.0518 0.0829
Brugia malayi Calcitonin receptor-like protein seb-1 0.0106 0.2113 0.2277
Echinococcus granulosus Pleckstrin y 0.0026 0.0296 0.0291
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1048 0.4663
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0015 0.0019
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.0019 0.0138 0.0133
Brugia malayi 6-phosphofructokinase 0.0106 0.2105 0.2268
Echinococcus granulosus Ribosomal protein S6 kinase beta 2 0.0136 0.2778 0.2774
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Trichomonas vaginalis alpha chimerin, putative 0.0026 0.0296 0.0306
Brugia malayi Cytohesin 3 0.0026 0.0296 0.0306
Plasmodium vivax multidomain scavenger receptor, putative 0.0023 0.0221 0.0176
Echinococcus multilocularis Arf GAP and Pleckstrin domain containing protein 0.0026 0.0296 0.0282
Brugia malayi hypothetical protein 0.0035 0.051 0.0537
Echinococcus granulosus Protein son of sevenless 0.0014 0.0015 0.0009
Echinococcus multilocularis actin binding protein anillin 0.0026 0.0296 0.0282
Echinococcus multilocularis DCC interacting protein 13 beta 0.0026 0.0296 0.0282
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Echinococcus granulosus calcium dependent secretion activator 1 0.0026 0.0296 0.0291
Trypanosoma cruzi NEK family Serine/threonine-protein kinase, putative 0.0026 0.0296 0.0452
Trichomonas vaginalis guanyl-nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0036 0.0518 0.0546
Loa Loa (eye worm) AGC/PKN protein kinase 0.0136 0.2778 0.2999
Echinococcus granulosus protein kinase c epsilon type 0.0136 0.2778 0.2774
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus sodium:potassium dependent atpase beta subunit 0.0259 0.5573 0.557
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Echinococcus multilocularis sodium:potassium dependent atpase beta subunit 0.0259 0.5573 0.5566
Trichomonas vaginalis ap endonuclease, putative 0.0018 0.0124 0.0118
Schistosoma mansoni hypothetical protein 0.0034 0.047 0.0597
Loa Loa (eye worm) hypothetical protein 0.0031 0.0412 0.0431
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Entamoeba histolytica protein kinase, putative 0.0421 0.9228 1
Trichomonas vaginalis centaurin/arf, putative 0.0026 0.0296 0.0306
Plasmodium falciparum ATP-dependent 6-phosphofructokinase 0.0029 0.0357 0.0421
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.0019 0.0138 0.0175
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Leishmania major protein kinase, putative 0.0029 0.0374 0.1264
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0066 0.1199 0.2264
Echinococcus granulosus 3 hydroxyacyl coenzyme A dehydrogenase type 2 0.0066 0.1199 0.1194
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.2105 0.2268
Leishmania major hypothetical protein, conserved 0.0026 0.0296 0.087
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.1048 0.1945
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Schistosoma mansoni growth factor receptor-bound protein 0.0026 0.0296 0.0376
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.0546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0045 0.0736 0.0783
Giardia lamblia Kinase, AGC PKA 0.0263 0.5651 1
Onchocerca volvulus 0.0019 0.0138 0.0146
Schistosoma mansoni lipoxygenase 0.0063 0.1143 0.145
Loa Loa (eye worm) AGC/AKT protein kinase 0.0421 0.9228 1
Echinococcus granulosus myotubularin protein 13 0.0026 0.0296 0.0291
Schistosoma mansoni centaurin alpha 0.0026 0.0296 0.0376
Trichomonas vaginalis protein transport protein sec7, putative 0.0026 0.0296 0.0306
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0106 0.2113 0.2277
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0034 0.047 0.0456
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Entamoeba histolytica protein kinase, putative 0.0029 0.0374 0.039
Schistosoma mansoni zinc finger protein 0.0026 0.0296 0.0376
Echinococcus granulosus RUN 0.0023 0.0221 0.0216
Entamoeba histolytica protein kinase, putative 0.0029 0.0374 0.039
Schistosoma mansoni myotubularin-related protein 0.0026 0.0296 0.0376
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Entamoeba histolytica hypothetical protein 0.0029 0.0374 0.039
Schistosoma mansoni dep domain containing protein 0.0019 0.0138 0.0175
Brugia malayi Uncoordinated protein 104 0.0026 0.0296 0.0306
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0254 0.5456 0.5906
Echinococcus multilocularis ribosomal protein s6 kinase beta 1 0.0136 0.2778 0.2767
Schistosoma mansoni goodpasture antigen-binding protein 0.0026 0.0296 0.0376
Trypanosoma brucei Serine/threonine-protein kinase NEK21, putative 0.0029 0.0374 0.0275
Onchocerca volvulus Protein melted homolog 0.0026 0.0296 0.0335
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0045 0.0736 0.0934
Echinococcus multilocularis geminin 0.0362 0.788 0.7877
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0015 0.0019
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Echinococcus granulosus cytohesin 1 0.0026 0.0296 0.0291
Trichomonas vaginalis kinesin light chain, putative 0.0026 0.0296 0.0306
Echinococcus multilocularis beta LACTamase domain containing family member 0.0036 0.0518 0.0503
Brugia malayi 3-hydroxyacyl-CoA dehydrogenase type II 0.0066 0.1199 0.1285
Schistosoma mansoni dishevelled 0.0019 0.0138 0.0175
Brugia malayi Cadps2 protein 0.0026 0.0296 0.0306
Trichomonas vaginalis CMGC family protein kinase 0.0061 0.1098 0.1176
Echinococcus multilocularis GPCR, family 2 0.0034 0.047 0.0456
Leishmania major folate/biopterin transporter, putative 0.0029 0.0374 0.1264
Loa Loa (eye worm) hypothetical protein 0.0023 0.0221 0.0224
Entamoeba histolytica PH domain containing protein kinase, putative 0.0289 0.6237 0.6754
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1048 0.133
Schistosoma mansoni dishevelled 0.0019 0.0138 0.0175
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.1048 0.4663
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0026 0.0296 0.0306
Plasmodium vivax PH domain containing protein 0.0026 0.0296 0.0312
Entamoeba histolytica protein kinase, putative 0.0029 0.0374 0.039
Echinococcus granulosus Polycystic kidney disease protein 0.0023 0.0221 0.0216
Echinococcus multilocularis arachidonate 5 lipoxygenase 0.0063 0.1143 0.113
Echinococcus granulosus arf GAP with SH3 domain ANK repeat and PH 0.0026 0.0296 0.0291
Schistosoma mansoni hypothetical protein 0.0034 0.047 0.0597
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Echinococcus multilocularis protein kinase c epsilon type 0.0136 0.2778 0.2767
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.0546
Echinococcus granulosus nervana 2 0.0259 0.5573 0.557
Brugia malayi hypothetical protein 0.0023 0.0221 0.0224
Mycobacterium ulcerans hypothetical protein 0.0036 0.0518 0.1987
Trypanosoma cruzi ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.2105 0.3359
Mycobacterium ulcerans lipase LipD 0.0036 0.0518 0.1987
Echinococcus granulosus protein kinase c iota type 0.0136 0.2778 0.2774
Brugia malayi hypothetical protein 0.0019 0.0138 0.0133
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Entamoeba histolytica hypothetical protein 0.0029 0.0374 0.039
Trypanosoma cruzi NIMA-related kinase, putative 0.0029 0.0374 0.0578
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0018 0.0124 0.0118
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Trichomonas vaginalis ankyrin repeat and FYVE domain containing protein, putative 0.0026 0.0296 0.0306
Loa Loa (eye worm) GTP-ase activating protein for Arf containing protein 0.0026 0.0296 0.0306
Trichomonas vaginalis D-aminoacylase, putative 0.0036 0.0518 0.0546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Onchocerca volvulus outspread protein homolog 0.0026 0.0296 0.0335
Schistosoma mansoni 6-phosphofructokinase 0.0106 0.2105 0.2671
Loa Loa (eye worm) 6-phosphofructokinase 0.0106 0.2105 0.2268
Onchocerca volvulus 0.0023 0.0221 0.0246
Toxoplasma gondii 6-phosphofructokinase 0.0029 0.0357 0.0273
Loa Loa (eye worm) variant SH3 domain-containing protein 0.0031 0.0412 0.0431
Schistosoma mansoni ras GTP exchange factor son of sevenless 0.0014 0.0015 0.0019
Echinococcus granulosus mitogen activated protein kinase 0.0061 0.1098 0.1094
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Entamoeba histolytica hypothetical protein, conserved 0.0026 0.0296 0.0306
Entamoeba histolytica hypothetical protein 0.0026 0.0296 0.0306
Trypanosoma brucei NEK family Serine/threonine-protein kinase, putative 0.0029 0.0374 0.0275
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0254 0.5456 0.5906
Brugia malayi Plekhf2 protein 0.0026 0.0296 0.0306
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus oxysterol binding protein 1 0.0026 0.0296 0.0291
Trichomonas vaginalis penicillin-binding protein, putative 0.0036 0.0518 0.0546
Trichomonas vaginalis AGC family protein kinase 0.0421 0.9228 1
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0231 0.4931 0.5336
Trypanosoma brucei PH domain containing protein, putative 0.0026 0.0296 0.0189
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Brugia malayi N-terminal motif family protein 0.0385 0.8414 0.9116
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Echinococcus multilocularis Pleckstrin domain containing protein, family B 0.0026 0.0296 0.0282
Schistosoma mansoni phosphoinositol 4-phosphate adaptor protein 0.0026 0.0296 0.0376
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Trichomonas vaginalis glucosylceramidase, putative 0.0254 0.5456 0.5906
Echinococcus granulosus DCC interacting protein 13 beta 0.0026 0.0296 0.0291
Leishmania major protein kinase, putative,serine/threonine protein kinase, putative 0.0029 0.0374 0.1264
Schistosoma mansoni lipoxygenase 0.0023 0.0221 0.0281
Trypanosoma brucei protein kinase, putative 0.0061 0.1098 0.107
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0221 0.0216
Schistosoma mansoni guanine-nucleotide-exchange-factor 0.0014 0.0015 0.0019
Brugia malayi exodeoxyribonuclease III family protein 0.0018 0.0124 0.0118
Loa Loa (eye worm) hypothetical protein 0.0073 0.1353 0.1452
Brugia malayi beta-lactamase family protein 0.0036 0.0518 0.0546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Entamoeba histolytica hypothetical protein 0.0026 0.0296 0.0306
Plasmodium falciparum phosphatidylinositol transfer protein, putative 0.0026 0.0296 0.0312
Schistosoma mansoni serine/threonine protein kinase 0.0061 0.1098 0.1394
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi 6-phosphofructokinase 0.0106 0.2105 0.2268
Echinococcus multilocularis regulator of G protein signaling 7 0.0019 0.0138 0.0123
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.1098 0.1741
Giardia lamblia Kinase, CMGC MAPK 0.0061 0.1098 0.1763
Echinococcus multilocularis myotubularin protein 13 0.0026 0.0296 0.0282
Echinococcus multilocularis FERM and pleckstrin domain containing protein 0.0026 0.0296 0.0282
Brugia malayi Pleckstrin Homology Domain 0.0026 0.0296 0.0306
Schistosoma mansoni cell adhesion molecule 0.0015 0.0057 0.0072
Echinococcus multilocularis type II inositol 3,4 bisphosphate 4 phosphatase 0.0026 0.0296 0.0282
Echinococcus multilocularis roundabout 2 0.0015 0.0057 0.0042
Trypanosoma cruzi mitogen activated protein kinase 2, putative 0.0061 0.1098 0.1741
Schistosoma mansoni transcription factor LCR-F1 0.0035 0.051 0.0647
Entamoeba histolytica PH domain containing protein kinase, putative 0.0289 0.6237 0.6754
Plasmodium vivax rac-beta serine/threonine protein kinase, putative 0.0263 0.5651 1
Entamoeba histolytica hypothetical protein 0.0035 0.051 0.0537
Mycobacterium tuberculosis Probable 6-phosphofructokinase PfkA (phosphohexokinase) (phosphofructokinase) 0.0106 0.2105 0.4172
Loa Loa (eye worm) uncoordinated protein 104 0.0026 0.0296 0.0306
Schistosoma mansoni hypothetical protein 0.0035 0.051 0.0647
Echinococcus multilocularis arf GAP with SH3 domain, ANK repeat and PH 0.0026 0.0296 0.0282
Entamoeba histolytica hypothetical protein 0.0026 0.0296 0.0306
Echinococcus multilocularis oxysterol binding protein 1 0.0026 0.0296 0.0282
Trichomonas vaginalis ankyrin repeat-containing protein, putative 0.0026 0.0296 0.0306
Echinococcus granulosus neurotracting:lsamp:neurotrimin:obcam 0.0015 0.0057 0.0051
Schistosoma mansoni serine/threonine protein kinase 0.0136 0.2778 0.3526
Trypanosoma brucei protein kinase, putative 0.0029 0.0374 0.0275
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi hypothetical protein 0.0023 0.0221 0.0224
Trypanosoma brucei rac serine-threonine kinase, putative 0.0421 0.9228 1
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Plasmodium vivax conserved Plasmodium protein, unknown function 0.0026 0.0296 0.0312
Schistosoma mansoni rab6-interacting 0.0023 0.0221 0.0281
Entamoeba histolytica pyrophosphate-dependent phosphofructokinase 0.0029 0.0357 0.0371
Echinococcus multilocularis nervana 2 0.0259 0.5573 0.5566
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Schistosoma mansoni serine/threonine-protein kinase 0.0289 0.6237 0.7916
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Echinococcus granulosus pleckstrin y domain containing family A 0.0026 0.0296 0.0291
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0045
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.0019 0.0138 0.0146
Trypanosoma cruzi NIMA-related kinase, putative 0.0029 0.0374 0.0578
Loa Loa (eye worm) AGC/NDR protein kinase 0.0136 0.2778 0.2999
Plasmodium vivax calcium-dependent protein kinase 7, putative 0.0029 0.0374 0.0453
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Echinococcus granulosus serine/threonine protein kinase 0.0289 0.6237 0.6235
Trypanosoma brucei ATP-dependent 6-phosphofructokinase, glycosomal 0.0106 0.2105 0.2176
Echinococcus multilocularis serine threonine protein kinase nrc serine threonine protein kinase gad 0.0263 0.5651 0.5644
Brugia malayi beta-lactamase 0.0036 0.0518 0.0546
Brugia malayi Protein kinase domain containing protein 0.0136 0.2778 0.2999
Schistosoma mansoni serine/threonine-protein kinase 0.0289 0.6237 0.7916
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Trypanosoma brucei serine/threonine-protein kinase NRKB, putative 0.0029 0.0374 0.0275
Schistosoma mansoni ap endonuclease 0.0018 0.0124 0.0157
Leishmania major ATP-dependent phosphofructokinase 0.0106 0.2105 1
Trichomonas vaginalis ankyrin 2,3/unc44, putative 0.0026 0.0296 0.0306
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.2105 0.2268
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Trypanosoma cruzi mitogen-activated protein kinase 11, putative 0.0061 0.1098 0.1741
Echinococcus granulosus mitogen activated protein kinase 3 0.0061 0.1098 0.1094
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.1048 0.133
Loa Loa (eye worm) RhoGEF domain-containing protein 0.0026 0.0296 0.0306
Toxoplasma gondii CMGC kinase, MAPK family (ERK) MAPK-1 0.0061 0.1098 0.1144
Trichomonas vaginalis glucosylceramidase, putative 0.0167 0.348 0.3761
Mycobacterium leprae PROBABLE 6-PHOSPHOFRUCTOKINASE PFKA (PHOSPHOHEXOKINASE) (PHOSPHOFRUCTOKINASE) 0.0106 0.2105 1
Echinococcus multilocularis calcium dependent secretion activator 1 0.0026 0.0296 0.0282
Onchocerca volvulus Putative zinc finger protein 0.0026 0.0296 0.0335
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0736 0.0722
Echinococcus granulosus lipoxygenase domain containing protein 0.0023 0.0221 0.0216
Schistosoma mansoni hypothetical protein 0.0026 0.0296 0.0376
Trypanosoma cruzi Protein kinase B 0.0289 0.6237 1
Echinococcus multilocularis beta 1 syntrophin 0.0026 0.0296 0.0282
Loa Loa (eye worm) hypothetical protein 0.0036 0.0518 0.0546
Loa Loa (eye worm) hypothetical protein 0.0026 0.0296 0.0306
Trichomonas vaginalis phosphofructokinase, putative 0.0106 0.2105 0.2268
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0036 0.0518 0.1987
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0045 0.0736 0.0731
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Toxoplasma gondii phosphatidylinositol transfer protein 0.0026 0.0296 0.0202
Loa Loa (eye worm) doublecortin family protein 0.0023 0.0221 0.0224
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Onchocerca volvulus Abnormal cell migration protein 10 homolog 0.0026 0.0296 0.0335
Echinococcus multilocularis protein kinase c iota type 0.0136 0.2778 0.2767
Trichomonas vaginalis AGC family protein kinase 0.0136 0.2778 0.2999
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0374 0.039
Echinococcus granulosus GPCR family 2 0.0034 0.047 0.0465
Leishmania major 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0066 0.1199 0.5427
Brugia malayi PH domain containing protein 0.0026 0.0296 0.0306
Loa Loa (eye worm) hypothetical protein 0.0023 0.0221 0.0224
Echinococcus multilocularis GRB2 associated binding protein 3 0.0026 0.0296 0.0282
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Echinococcus multilocularis Pleckstrin y 0.0026 0.0296 0.0282
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0045 0.0736 0.0722
Brugia malayi p70 ribosomal S6 kinase beta 0.0395 0.8641 0.9363
Echinococcus granulosus regulator of G protein signaling 7 0.0019 0.0138 0.0133
Loa Loa (eye worm) hypothetical protein 0.0015 0.0057 0.0045
Schistosoma mansoni zinc finger protein 0.0026 0.0296 0.0376
Entamoeba histolytica PH domain containing protein 0.0026 0.0296 0.0306
Mycobacterium ulcerans 6-phosphofructokinase 0.0106 0.2105 1
Entamoeba histolytica pleckstrin homology (PH) domain containing protein 0.0026 0.0296 0.0306
Entamoeba histolytica PH domain containing protein kinase, putative 0.0029 0.0374 0.039
Trypanosoma brucei hypothetical protein, conserved 0.0036 0.0518 0.0432
Echinococcus granulosus collagen type iv alpha 3 binding protein 0.0026 0.0296 0.0291
Trypanosoma cruzi phosphatidylinositol-4-phosphate 5-kinase, putative 0.0026 0.0296 0.0452
Echinococcus multilocularis serine threonine protein kinase 0.0136 0.2778 0.2767
Entamoeba histolytica phosphofructokinase, putative 0.0106 0.2105 0.2268
Trypanosoma cruzi hypothetical protein 0.0026 0.0296 0.0452
Loa Loa (eye worm) AGC/RSK/P70 protein kinase 0.0395 0.8641 0.9363
Echinococcus granulosus segment polarity protein dishevelled 0.0019 0.0138 0.0133
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0035 0.051 0.0496
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Brugia malayi TBC domain containing protein 0.0026 0.0296 0.0306
Trypanosoma cruzi PH domain containing protein, putative 0.0026 0.0296 0.0452
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.1048 0.1034
Trichomonas vaginalis conserved hypothetical protein 0.0026 0.0296 0.0306
Chlamydia trachomatis fructose-6-phosphate phosphotransferase 0.0029 0.0357 0.5
Onchocerca volvulus 0.0026 0.0296 0.0335
Trichomonas vaginalis phosphofructokinase, putative 0.0029 0.0357 0.0371
Echinococcus multilocularis mitogen activated protein kinase 3 0.0061 0.1098 0.1085
Echinococcus granulosus arf GAP with coiled coil ANK repeat and PH 0.0026 0.0296 0.0291
Plasmodium falciparum PH domain-containing protein, putative 0.0026 0.0296 0.0312
Entamoeba histolytica hypothetical protein 0.0035 0.051 0.0537
Trichomonas vaginalis glucosylceramidase, putative 0.0176 0.3683 0.3982
Trichomonas vaginalis AGC family protein kinase 0.0029 0.0374 0.039
Echinococcus granulosus rap guanine nucleotide exchange factor 1 0.0014 0.0015 0.0009
Entamoeba histolytica Rho guanine nucleotide exchange factor, putative 0.0026 0.0296 0.0306
Schistosoma mansoni syntrophin 0.0026 0.0296 0.0376

Activities

Activity type Activity value Assay description Source Reference
IC50 (functional) = 6 nM Antagonist activity at human CCR2 ChEMBL. 18990568

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

If you have references for this compound, please enter them in a user comment (below) or Contact us.