Detailed information for compound 1005116

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 1615.89 | Formula: C68H122N30O16
  • H donors: 27 H acceptors: 16 LogP: -10.6 Rotable bonds: 72
    Rule of 5 violations (Lipinski): 4
  • SMILES: NCCCC[C@@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)N[C@H](C(=O)O)Cc1ccc(cc1)O)CCCNC(=N)N)CCCCN)NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H](NC(=O)[C@@H]1CCCN1C(=O)[C@H]([C@H](O)C)N)CCC(=O)N)CCCNC(=N)N)C)CCCNC(=N)N)CCCNC(=N)N)CCCNC(=N)N
  • InChi: 1S/C68H122N30O16/c1-36(88-53(103)42(15-7-29-83-64(73)74)92-60(110)47(25-26-50(71)101)96-61(111)49-20-12-34-98(49)62(112)51(72)37(2)99)52(102)89-43(16-8-30-84-65(75)76)56(106)93-45(18-10-32-86-67(79)80)58(108)94-44(17-9-31-85-66(77)78)57(107)91-40(13-3-5-27-69)54(104)90-41(14-4-6-28-70)55(105)95-46(19-11-33-87-68(81)82)59(109)97-48(63(113)114)35-38-21-23-39(100)24-22-38/h21-24,36-37,40-49,51,99-100H,3-20,25-35,69-70,72H2,1-2H3,(H2,71,101)(H,88,103)(H,89,102)(H,90,104)(H,91,107)(H,92,110)(H,93,106)(H,94,108)(H,95,105)(H,96,111)(H,97,109)(H,113,114)(H4,73,74,83)(H4,75,76,84)(H4,77,78,85)(H4,79,80,86)(H4,81,82,87)/t36-,37+,40-,41-,42-,43-,44-,45-,46-,47-,48-,49-,51-/m0/s1
  • InChiKey: GBWNVGJPAAAKFV-XVVOLBHMSA-N  


Substructure search Similarity search

Network

Hover on a compound node to display the structore

Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens furin (paired basic amino acid cleaving enzyme) Starlite/ChEMBL References
Homo sapiens proprotein convertase subtilisin/kexin type 7 Starlite/ChEMBL References
Homo sapiens proprotein convertase subtilisin/kexin type 5 Starlite/ChEMBL References
Rattus norvegicus Proprotein convertase subtilisin/kexin type 6 Starlite/ChEMBL References
Homo sapiens proprotein convertase subtilisin/kexin type 4 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Furin-like protease 1, isoforms 1/1-X/2 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Proprotein convertase subtilisin/kexin type 6 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Giardia lamblia High cysteine non-variant cyst protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis Get druggable targets OG5_127788 All targets in OG5_127788
Trichomonas vaginalis Involucrin, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) Get druggable targets OG5_127788 All targets in OG5_127788
Schistosoma japonicum Neurogenic locus notch protein homolog precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR006209,EGF-like;IPR013091,EGF calcium-binding;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic acid and as Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus fibrillin 1 Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein Group 1 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum IPR013091,EGF calcium-binding;IPR013111,EGF, extracellular;IPR001881,EGF-like calcium-binding;IPR006210,EGF;IPR000152,Aspartic a Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania infantum surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trypanosoma cruzi hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma japonicum Endoprotease bli-4 precursor, putative Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi Protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein, conserved Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi endoprotease bli-4 precursor Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein TMK-like Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis expressed conserved protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica pro protein convertase subtilisin/kexinType 5 precursor, putative Get druggable targets OG5_126560 All targets in OG5_126560
Schistosoma mansoni notch Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) hypothetical protein Get druggable targets OG5_127788 All targets in OG5_127788
Loa Loa (eye worm) TK/FER protein kinase Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica cysteine surface protein, putative Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus furin Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Giardia lamblia High cysteine membrane protein Group 2 Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis microtubule associated protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania major surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Onchocerca volvulus Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica CXXC-rich protein Get druggable targets OG5_126560 All targets in OG5_126560
Brugia malayi celfurPC protein Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus multilocularis coiled coil domain containing protein 41 Get druggable targets OG5_126560 All targets in OG5_126560
Echinococcus granulosus hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania mexicana surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase domain containing protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica protein kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Candida albicans subtilisin-like endoprotease involved in processing C. albicans Sap2 Get druggable targets OG5_127788 All targets in OG5_127788
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica hypothetical protein Get druggable targets OG5_126560 All targets in OG5_126560
Leishmania braziliensis surface antigen-like protein Get druggable targets OG5_126560 All targets in OG5_126560
Trichomonas vaginalis DNA double-strand break repair Rad50 ATPase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
Loa Loa (eye worm) endoprotease bli-4 Get druggable targets OG5_127788 All targets in OG5_127788
Entamoeba histolytica tyrosine kinase, putative Get druggable targets OG5_126560 All targets in OG5_126560
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Brugia malayi neuroendocrine convertase 1 precursor 0.0456 0.564 0.6247
Schistosoma mansoni tyrosine kinase 0.0167 0.1747 0.171
Brugia malayi proprotein convertase 2 0.0456 0.564 0.6247
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0041 0.0058 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0037 0 0.5
Schistosoma mansoni microtubule-associated protein tau 0.078 1 1
Echinococcus multilocularis epidermal growth factor receptor 0.0167 0.1747 0.171
Schistosoma mansoni subfamily S8B unassigned peptidase (S08 family) 0.0706 0.9002 0.8998
Schistosoma mansoni inositol monophosphatase 0.0041 0.0058 0.0014
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0037 0 0.5
Trichomonas vaginalis leucine-rich repeat protein, BspA family 0.0158 0.1624 0.2902
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Echinococcus granulosus furin 0.0706 0.9002 0.8998
Echinococcus multilocularis microtubule associated protein 2 0.078 1 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Loa Loa (eye worm) hypothetical protein 0.0706 0.9002 1
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Echinococcus granulosus geminin 0.0188 0.204 0.2005
Trichomonas vaginalis neuroendocrine convertase 2 precursor, putative 0.0158 0.1624 0.2902
Loa Loa (eye worm) hypothetical protein 0.0139 0.1369 0.1465
Echinococcus multilocularis proprotein convertase subtilisin:kexin type 5 0.0442 0.5454 0.5434
Loa Loa (eye worm) hypothetical protein 0.0264 0.3054 0.335
Schistosoma mansoni furin-1 (S08 family) 0.0299 0.3522 0.3494
Loa Loa (eye worm) hypothetical protein 0.0139 0.1369 0.1465
Onchocerca volvulus Huntingtin homolog 0.0139 0.1369 0.5
Trichomonas vaginalis hypothetical protein 0.0158 0.1624 0.2902
Echinococcus granulosus proprotein convertase subtilisin:kexin type 5 0.0442 0.5454 0.5434
Schistosoma mansoni subfamily S8B non-peptidase homologue (S08 family) 0.0192 0.2092 0.2057
Echinococcus granulosus inositol monophosphatase 1 0.0041 0.0058 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Brugia malayi celfurPC protein 0.0549 0.6884 0.7635
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0041 0.0058 0.5
Brugia malayi Furin-like cysteine rich region family protein 0.0167 0.1747 0.1901
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Echinococcus multilocularis geminin 0.0188 0.204 0.2005
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.5454 1
Brugia malayi endoprotease bli-4 precursor 0.0706 0.9002 1
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0058 0.5
Loa Loa (eye worm) TK/EGFR protein kinase 0.0167 0.1747 0.1888
Schistosoma mansoni inositol monophosphatase 0.0041 0.0058 0.0014
Echinococcus multilocularis inositol monophosphatase 1 0.0041 0.0058 0.0014
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0192 0.2092 0.377
Schistosoma mansoni hypothetical protein 0.0158 0.1624 0.1587
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0058 0.5
Echinococcus multilocularis Furin 1 0.0192 0.2092 0.2057
Schistosoma mansoni hypothetical protein 0.0188 0.204 0.2005
Loa Loa (eye worm) endoprotease bli-4 0.0706 0.9002 1
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0041 0.0058 0.5
Onchocerca volvulus Huntingtin homolog 0.0139 0.1369 0.5
Echinococcus multilocularis neuroendocrine convertase 2 0.0456 0.564 0.5621
Trichomonas vaginalis proprotein convertase subtilisin/kexin type, putative 0.0158 0.1624 0.2902
Trichomonas vaginalis Clan SB, family S8, subtilisin-like serine peptidase 0.0442 0.5454 1
Echinococcus multilocularis 0.0549 0.6884 0.687
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Echinococcus granulosus Furin 1 0.0192 0.2092 0.2057
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0058 0.5
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0041 0.0058 1
Schistosoma mansoni hypothetical protein 0.0188 0.204 0.2005
Echinococcus granulosus neuroendocrine convertase 2 0.0456 0.564 0.5621
Brugia malayi hypothetical protein 0.0139 0.1369 0.1479
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.1624 0.2902
Brugia malayi Inositol-1 0.0041 0.0058 0.0016
Loa Loa (eye worm) proprotein convertase 2 0.0192 0.2092 0.2274
Giardia lamblia High cysteine membrane protein Group 2 0.025 0.2867 1
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0041 0.0058 0.5
Echinococcus granulosus epidermal growth factor receptor 0.0167 0.1747 0.171

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.047 uM Inhibition of human recombinant furin assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721
Ki (binding) = 0.624 uM Inhibition of human recombinant PC4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721
Ki (binding) = 0.649 uM Inhibition of human recombinant PC5/6 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721
Ki (binding) = 1.02 uM Inhibition of rat PACE4 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721
Ki (binding) = 1.22 uM Inhibition of human recombinant PC7 assessed as fluorescent Pyr-RTKR-AMC substrate cleavage ChEMBL. 17537721

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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