Detailed information for compound 1005202

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 471.591 | Formula: C29H33N3O3
  • H donors: 0 H acceptors: 2 LogP: 4.73 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCCCN(C(=O)C1CCC1)CC(=O)N1c2ccccc2n2c(C1c1ccc(cc1)OC)ccc2
  • InChi: 1S/C29H33N3O3/c1-3-4-18-30(29(34)22-9-7-10-22)20-27(33)32-25-12-6-5-11-24(25)31-19-8-13-26(31)28(32)21-14-16-23(35-2)17-15-21/h5-6,8,11-17,19,22,28H,3-4,7,9-10,18,20H2,1-2H3
  • InChiKey: KGXURCDXGLPKNG-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Rattus norvegicus Cannabinoid CB1 receptor Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Onchocerca volvulus 0.0073 0.0623 0.101
Echinococcus multilocularis microtubule associated protein 2 0.0694 0.7672 0.765
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0083 0.0736 0.1301
Mycobacterium tuberculosis Conserved hypothetical protein 0.006 0.047 0.0507
Brugia malayi nuclear receptor RXR 0.0044 0.0289 0.0511
Brugia malayi Pre-SET motif family protein 0.0062 0.0488 0.0862
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0039 0.0235 0.0188
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0038 0.0222 0.3557
Schistosoma mansoni hypothetical protein 0.0358 0.3858 0.5029
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0044 0.0289 0.0377
Brugia malayi beta-lactamase family protein 0.0073 0.0623 0.11
Onchocerca volvulus 0.0083 0.0736 0.1226
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0046 0.0314 0.0409
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0053 0.0386 0.0683
Loa Loa (eye worm) intermediate filament protein 0.0027 0.0093 0.0165
Echinococcus granulosus ecdysone induced protein 78C 0.0083 0.0736 0.0848
Mycobacterium ulcerans DNA polymerase IV 0.006 0.047 0.1426
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0032 0.0156 0.0082
Loa Loa (eye worm) hypothetical protein 0.0053 0.0386 0.0683
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0073 0.0623 0.11
Echinococcus granulosus histone lysine methyltransferase setb 0.0062 0.0488 0.052
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.006 0.047 0.0831
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0083 0.0736 0.0649
Loa Loa (eye worm) steroid hormone receptor 0.0083 0.0736 0.1301
Plasmodium vivax JmjC domain containing protein 0.0032 0.0156 0.2502
Schistosoma mansoni tar DNA-binding protein 0.0334 0.3583 0.467
Schistosoma mansoni coup transcription factor 0.0083 0.0736 0.0959
Loa Loa (eye worm) MBCTL1 0.0053 0.0386 0.0683
Brugia malayi nuclear receptor NHR-67 0.0039 0.0235 0.0416
Schistosoma mansoni ap endonuclease 0.0038 0.0222 0.0289
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0156 0.0275
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Echinococcus granulosus geminin 0.0358 0.3858 0.4968
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0736 0.0848
Schistosoma mansoni nuclear receptor nhr-48 0.0039 0.0235 0.0307
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0204 0.2106 0.3839
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0053 0.0386 0.0296
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1346 0.1265
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0039 0.0235 0.0188
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0083 0.0736 0.0959
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Leishmania major hypothetical protein, conserved 0.0032 0.0156 0.2497
Plasmodium falciparum JmjC domain-containing protein, putative 0.0032 0.0156 0.7021
Echinococcus multilocularis lysine specific demethylase 6a 0.0032 0.0156 0.0063
Onchocerca volvulus 0.0048 0.0334 0.0458
Leishmania major hypothetical protein, conserved 0.0073 0.0623 0.9983
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0083 0.0736 0.0959
Mycobacterium ulcerans beta-lactamase 0.0073 0.0623 0.1888
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0334 0.3583 0.6332
Loa Loa (eye worm) hypothetical protein 0.0027 0.0093 0.0165
Echinococcus granulosus polycomb protein SCMH1 0.0046 0.0314 0.0291
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.047 0.0831
Schistosoma mansoni alpha glucosidase 0.0073 0.0624 0.0813
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0623 0.0941
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.01 0.1596
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0624 0.0943
Mycobacterium ulcerans DNA polymerase IV 0.006 0.047 0.1426
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Brugia malayi nuclear hormone receptor family member odr-7 0.0039 0.0235 0.0416
Treponema pallidum exodeoxyribonuclease (exoA) 0.0038 0.0222 0.5
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.0027 0.01 0.0012
Schistosoma mansoni retinoic acid receptor RXR 0.0083 0.0736 0.0959
Schistosoma mansoni jumonji domain containing protein 0.0032 0.0156 0.0203
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0235 0.0144
Echinococcus granulosus beta LACTamase domain containing family member 0.0073 0.0623 0.0698
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0073 0.0623 0.1888
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1346 0.1755
Echinococcus granulosus microtubule associated protein 2 0.0694 0.7672 1
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0083 0.0736 0.0959
Mycobacterium ulcerans lipase LipD 0.0073 0.0623 0.1888
Brugia malayi hypothetical protein 0.0044 0.0289 0.0511
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0624 0.0943
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0462 0.0486
Trypanosoma brucei glucosidase, putative 0.0073 0.0624 1
Loa Loa (eye worm) beta-lactamase 0.0073 0.0623 0.11
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0624 1
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0222 0.3563
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0083 0.0736 0.1301
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.047 0.7538
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0121 0.1166 0.1415
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.047 0.7538
Brugia malayi N-terminal motif family protein 0.0204 0.2106 0.3722
Echinococcus granulosus lysine specific demethylase 5A 0.0121 0.1166 0.1415
Onchocerca volvulus Glucosylceramidase homolog 0.0339 0.3639 0.6764
Schistosoma mansoni survival motor neuron protein 0.0048 0.0334 0.0435
Brugia malayi nuclear hormone receptor 0.0039 0.0235 0.0416
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0736 0.0959
Schistosoma mansoni tar DNA-binding protein 0.0334 0.3583 0.467
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Echinococcus granulosus tar DNA binding protein 0.0334 0.3583 0.4604
Schistosoma mansoni ap endonuclease 0.0038 0.0222 0.0289
Onchocerca volvulus 0.0062 0.0488 0.0752
Echinococcus multilocularis FTZ F1 alpha 0.0083 0.0736 0.0649
Mycobacterium tuberculosis Probable lipase LipE 0.0073 0.0623 0.0819
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0259 0.4145
Schistosoma mansoni jumonji domain containing protein 0.0121 0.1166 0.1519
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0235 0.0188
Leishmania major DNA polymerase eta, putative 0.006 0.047 0.7538
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.006 0.047 0.038
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0073 0.0623 0.11
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0736 0.1301
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0032 0.0156 0.0063
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0083 0.0736 0.0649
Schistosoma mansoni thyroid hormone receptor 0.0083 0.0736 0.0959
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0083 0.0736 0.0649
Brugia malayi hypothetical protein 0.0044 0.0289 0.0511
Schistosoma mansoni intermediate filament proteins 0.0027 0.0093 0.0122
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0275
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0156 0.0275
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.006 0.047 0.0613
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0314 0.0409
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0469 0.5117 1
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Onchocerca volvulus 0.0046 0.0314 0.0421
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0623 0.0941
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0083 0.0736 0.0848
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0073 0.0623 0.0819
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1346 0.1755
Trichomonas vaginalis esterase, putative 0.0073 0.0623 0.0941
Mycobacterium ulcerans glutaminase 0.0309 0.3297 1
Echinococcus granulosus phd:f box containing protein 0.0032 0.0156 0.0082
Echinococcus multilocularis neutral alpha glucosidase AB 0.0073 0.0624 0.0535
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0083 0.0736 0.1301
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0038 0.0222 0.3557
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0624 0.0943
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0137 0.1346 0.2379
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0736 0.1301
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0032 0.0156 0.2497
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0083 0.0736 0.1301
Loa Loa (eye worm) hypothetical protein 0.0034 0.0178 0.0314
Onchocerca volvulus Bile acid receptor homolog 0.0083 0.0736 0.1226
Loa Loa (eye worm) jmjC domain-containing protein 0.0121 0.1166 0.2061
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0044 0.0289 0.0377
Schistosoma mansoni DNA polymerase eta 0.006 0.047 0.0613
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Schistosoma mansoni protein phosphatase 2C 0.0032 0.0156 0.0203
Brugia malayi Steroid receptor seven-up type 2 0.0083 0.0736 0.1301
Schistosoma mansoni tar DNA-binding protein 0.0334 0.3583 0.467
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Echinococcus granulosus thyroid hormone receptor alpha 0.0039 0.0235 0.0188
Echinococcus multilocularis ecdysone induced protein 78C 0.0083 0.0736 0.0649
Echinococcus granulosus histone acetyltransferase MYST2 0.0053 0.0386 0.0387
Plasmodium vivax hypothetical protein, conserved 0.0073 0.0623 1
Toxoplasma gondii exonuclease III APE 0.0038 0.0222 0.3557
Brugia malayi RNA binding protein 0.0334 0.3583 0.6332
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0623 0.9983
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni terminal deoxycytidyl transferase 0.006 0.047 0.0613
Loa Loa (eye worm) hypothetical protein 0.0204 0.2106 0.3722
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0511
Mycobacterium ulcerans esterase/lipase LipP 0.0073 0.0623 0.1888
Brugia malayi intermediate filament protein 0.0027 0.0093 0.0165
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0624 1
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0083 0.0736 0.1301
Loa Loa (eye worm) nuclear hormone receptor 0.0039 0.0235 0.0416
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.1166 0.1519
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.006 0.047 0.0507
Echinococcus granulosus JmjC domain containing protein 4 0.0032 0.0156 0.0082
Schistosoma mansoni zinc finger protein 0.0039 0.0235 0.0307
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0511
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Brugia malayi nuclear receptor NHR-88 0.0039 0.0235 0.0416
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Loa Loa (eye worm) hypothetical protein 0.006 0.047 0.0831
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0038 0.0222 0.013
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0044 0.0289 0.0198
Brugia malayi glutaminase DH11.1 0.0309 0.3297 0.5828
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0027 0.0093 0.0165
Brugia malayi jmjC domain containing protein 0.0032 0.0156 0.0275
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0038 0.0222 1
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0623 0.0811
Loa Loa (eye worm) transcription factor SMAD2 0.012 0.1152 0.2037
Echinococcus granulosus SAM and MBT domain containing protein 0.0046 0.0314 0.0291
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0488 0.0635
Brugia malayi jmjC domain containing protein 0.0121 0.1166 0.2061
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.047 0.7538
Trypanosoma brucei unspecified product 0.006 0.047 0.7538
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0083 0.0736 0.0959
Onchocerca volvulus 0.0192 0.1965 0.3571
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Loa Loa (eye worm) RNA binding protein 0.0334 0.3583 0.6332
Loa Loa (eye worm) hypothetical protein 0.0235 0.2461 0.435
Brugia malayi ecdysone receptor 0.0039 0.0235 0.0416
Mycobacterium tuberculosis Probable lipase LipD 0.0073 0.0623 0.0819
Brugia malayi latrophilin 2 splice variant baaae 0.0034 0.0178 0.0314
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0624 0.0943
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.0516 0.5658 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0137 0.1346 0.1265
Echinococcus multilocularis lysine specific demethylase 5A 0.0121 0.1166 0.1083
Echinococcus granulosus dna polymerase eta 0.006 0.047 0.0497
Trypanosoma brucei unspecified product 0.0041 0.0259 0.4145
Brugia malayi exodeoxyribonuclease III family protein 0.0038 0.0222 0.0392
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0736 0.1301
Schistosoma mansoni glutaminase 0.0309 0.3297 0.4298
Mycobacterium tuberculosis Conserved protein 0.0073 0.0623 0.0819
Onchocerca volvulus 0.0039 0.0235 0.0271
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0331 0.3552 0.6279
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0083 0.0736 0.0848
Loa Loa (eye worm) DR-78 0.0039 0.0235 0.0416
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.006 0.047 0.7538
Brugia malayi Intermediate filament tail domain containing protein 0.0027 0.0093 0.0165
Mycobacterium leprae conserved hypothetical protein 0.0073 0.0623 0.5
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0039 0.0235 0.0416
Trypanosoma cruzi hypothetical protein, conserved 0.0073 0.0623 0.9983
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0235 0.0307
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Trypanosoma brucei hypothetical protein, conserved 0.0073 0.0623 0.9983
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0235 0.0416
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0156 0.2497
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0222 0.022
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0083 0.0736 0.0649
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0083 0.0736 0.1301
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0062 0.0488 0.0635
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0736 0.0649
Brugia malayi Pre-SET motif family protein 0.0429 0.4662 0.8241
Brugia malayi Glycosyl hydrolases family 31 protein 0.0073 0.0624 0.1102
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.0027 0.01 0.1596
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0083 0.0736 0.1301
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0259 0.4145
Mycobacterium leprae Probable lipase LipE 0.0073 0.0623 0.5
Brugia malayi ecdysteroid receptor 0.0083 0.0736 0.1301
Loa Loa (eye worm) glutaminase 2 0.0309 0.3297 0.5828
Leishmania major DNA polymerase kappa, putative 0.006 0.047 0.7538
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Trypanosoma cruzi DNA polymerase eta, putative 0.006 0.047 0.7538
Schistosoma mansoni hypothetical protein 0.0289 0.3069 0.4
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0032 0.0156 0.2497
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3847 0.6742
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0083 0.0736 0.1301
Loa Loa (eye worm) mbt repeat family protein 0.0046 0.0314 0.0555
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Brugia malayi orphan nuclear receptor NR2E1 0.0039 0.0235 0.0416
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0062 0.0488 0.0398
Schistosoma mansoni tar DNA-binding protein 0.0334 0.3583 0.467
Onchocerca volvulus 0.0073 0.0623 0.101
Echinococcus multilocularis lysosomal alpha glucosidase 0.0331 0.3552 0.3491
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0083 0.0736 0.0959
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0511
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0038 0.0222 0.017
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0083 0.0736 0.0959
Brugia malayi nuclear receptor RXR 0.0039 0.0235 0.0416
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.047 0.7538
Loa Loa (eye worm) hypothetical protein 0.0046 0.0314 0.0555
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0511
Mycobacterium tuberculosis Conserved protein 0.0073 0.0623 0.0819
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0623 0.0941
Schistosoma mansoni tar DNA-binding protein 0.0334 0.3583 0.467
Brugia malayi Nuclear hormone receptor-like 1 0.0083 0.0736 0.1301
Echinococcus granulosus jumonji domain containing 1A 0.0032 0.0156 0.0082
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0083 0.0736 0.0848
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0062 0.0488 0.0398
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Loa Loa (eye worm) hypothetical protein 0.0027 0.01 0.0176
Mycobacterium tuberculosis Probable hydrolase 0.0073 0.0623 0.0819
Brugia malayi hypothetical protein 0.0235 0.2461 0.435
Brugia malayi mbt repeat family protein 0.0046 0.0314 0.0555
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0062 0.0488 0.7818
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni nuclear receptor 0.0039 0.0235 0.0307
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.0073 0.0624 0.0943
Brugia malayi photoreceptor-specific nuclear receptor 0.0083 0.0736 0.1301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0083 0.0736 0.1301
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.005 0.0358 0.0633
Trypanosoma brucei glycosyl hydrolase-like protein 0.0027 0.01 0.1596
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0235 0.0271
Trypanosoma brucei unspecified product 0.0041 0.0259 0.4145
Trypanosoma brucei DNA polymerase kappa, putative 0.0041 0.0259 0.4145
Brugia malayi MH2 domain containing protein 0.012 0.1152 0.2037
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0137 0.1346 0.2379
Brugia malayi mbt repeat family protein 0.0046 0.0314 0.0555
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0488 0.0635
Echinococcus multilocularis thyroid hormone receptor alpha 0.0083 0.0736 0.0649
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0053 0.0386 0.0387
Brugia malayi jmjC domain containing protein 0.0032 0.0156 0.0275
Onchocerca volvulus 0.0039 0.0235 0.0271
Schistosoma mansoni alpha-glucosidase 0.0285 0.3028 0.3947
Schistosoma mansoni nuclear hormone receptor 0.0083 0.0736 0.0959
Echinococcus multilocularis dna polymerase kappa 0.006 0.047 0.038
Loa Loa (eye worm) pigment dispersing factor receptor c 0.005 0.0358 0.0633
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0083 0.0736 0.1301
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1346 0.1653
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0038 0.0222 0.0392
Brugia malayi RNA recognition motif domain containing protein 0.0334 0.3583 0.6332
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Leishmania major alpha glucosidase II subunit, putative 0.0073 0.0624 1
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0429 0.4662 0.8241
Echinococcus multilocularis survival motor neuron protein 1 0.0235 0.2461 0.239
Trypanosoma brucei DNA polymerase eta, putative 0.006 0.047 0.7538
Echinococcus multilocularis jumonji domain containing 1A 0.0032 0.0156 0.0063
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0083 0.0736 0.1301
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0083 0.0736 0.1301
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0624 0.0943
Onchocerca volvulus 0.0488 0.5336 1
Brugia malayi steroid hormone receptor 0.0083 0.0736 0.1301
Brugia malayi TAR-binding protein 0.0334 0.3583 0.6332
Schistosoma mansoni hypothetical protein 0.0358 0.3858 0.5029
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.0073 0.0624 1
Brugia malayi Nuclear hormone receptor E75 0.0039 0.0235 0.0416
Schistosoma mansoni hypothetical protein 0.0048 0.0334 0.0435
Trichomonas vaginalis alpha-glucosidase, putative 0.0073 0.0624 0.0943
Echinococcus multilocularis JmjC domain containing protein 4 0.0032 0.0156 0.0063
Echinococcus granulosus nuclear receptor nhr 48 0.0039 0.0235 0.0188
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0039 0.0235 0.0144
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0624 1
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.0073 0.0624 1
Loa Loa (eye worm) TAR-binding protein 0.0334 0.3583 0.6332
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0039 0.0235 0.0416
Echinococcus granulosus dna polymerase kappa 0.006 0.047 0.0497
Schistosoma mansoni lamin 0.0027 0.0093 0.0122
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.0073 0.0624 0.1102
Brugia malayi ImpB/MucB/SamB family protein 0.006 0.047 0.0831
Echinococcus multilocularis dna polymerase eta 0.006 0.047 0.038
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0083 0.0736 0.1301
Echinococcus multilocularis nuclear receptor nhr 48 0.0039 0.0235 0.0144
Echinococcus multilocularis polycomb protein SCMH1 0.0046 0.0314 0.0223
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0038 0.0222 0.3557
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0121 0.1166 0.1083
Schistosoma mansoni nuclear receptor 0.0039 0.0235 0.0307
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.006 0.047 0.0667
Loa Loa (eye worm) glutaminase 0.0309 0.3297 0.5828
Echinococcus granulosus neutral alpha glucosidase AB 0.0073 0.0624 0.07
Brugia malayi jmjC domain containing protein 0.0032 0.0156 0.0275
Trichomonas vaginalis sucrase-isomaltase, putative 0.0073 0.0624 0.0943
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0289 0.0511
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0083 0.0736 0.1226
Plasmodium vivax SET domain protein, putative 0.0062 0.0488 0.7831
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0039 0.0235 0.0144
Trichomonas vaginalis glutaminase, putative 0.0309 0.3297 0.5753
Mycobacterium ulcerans hypothetical protein 0.0073 0.0623 0.1888
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0275
Schistosoma mansoni alpha-glucosidase 0.0285 0.3028 0.3947
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0083 0.0736 0.1301
Schistosoma mansoni phosphatidylserine receptor 0.0032 0.0156 0.0203
Echinococcus granulosus lysine specific demethylase 6a 0.0032 0.0156 0.0082
Schistosoma mansoni jumonji/arid domain-containing protein 0.0121 0.1166 0.1519
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.047 0.7538
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Toxoplasma gondii histone lysine demethylase JMJC1/KDM5D/JARID1D 0.0032 0.0156 0.2497
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Toxoplasma gondii histone lysine demethylase JMJD6a 0.0032 0.0156 0.2497
Entamoeba histolytica deoxycytidyl transferase, putative 0.006 0.047 0.707
Schistosoma mansoni nuclear hormone receptor 0.0039 0.0235 0.0307
Loa Loa (eye worm) MH2 domain-containing protein 0.012 0.1152 0.2037
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0083 0.0736 0.0848
Onchocerca volvulus Protein ultraspiracle homolog 0.0083 0.0736 0.1226
Brugia malayi conserved hypotetical protein 0.0039 0.0235 0.0416
Brugia malayi beta-lactamase family protein 0.0073 0.0623 0.11
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0083 0.0736 0.0848
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0083 0.0736 0.0848
Onchocerca volvulus 0.0073 0.0623 0.101
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0044 0.0289 0.0511
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0032 0.0156 0.0203
Loa Loa (eye worm) hypothetical protein 0.0032 0.0156 0.0275
Echinococcus multilocularis SAM and MBT domain containing protein 0.0046 0.0314 0.0223
Trichomonas vaginalis maltase-glucoamylase, putative 0.0073 0.0624 0.0943
Schistosoma mansoni myelin transcription factor 1 myt1 0.0053 0.0386 0.0504
Trichomonas vaginalis D-aminoacylase, putative 0.0073 0.0623 0.0941
Giardia lamblia DINP protein human, muc B family 0.006 0.047 1
Brugia malayi nuclear receptor NHR-88 0.0083 0.0736 0.1301
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.0516 0.5658 1
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0039 0.0235 0.0144
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0083 0.0736 0.0649
Brugia malayi Nuclear hormone receptor-like 1 0.0044 0.0289 0.0511
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0083 0.0736 0.1301
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0083 0.0736 0.1301
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0073 0.0623 0.0819
Loa Loa (eye worm) hypothetical protein 0.0026 0.0088 0.0155
Schistosoma mansoni phd/f-box containing protein 0.0032 0.0156 0.0203
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0046 0.0314 0.0421
Trypanosoma brucei DNA polymerase IV, putative 0.006 0.047 0.7538
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0038 0.0222 0.3557
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.006 0.047 0.0497
Echinococcus granulosus lysosomal alpha glucosidase 0.0331 0.3552 0.4564
Trichomonas vaginalis glucosylceramidase, putative 0.0516 0.5658 1
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0137 0.1346 0.1755
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Brugia malayi hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0039 0.0235 0.0307
Brugia malayi Glycosyl hydrolases family 31 protein 0.0331 0.3552 0.6279
Echinococcus granulosus endonuclease exonuclease phosphatase 0.019 0.1946 0.2444
Loa Loa (eye worm) hypothetical protein 0.0073 0.0623 0.11
Trypanosoma brucei DNA polymerase kappa, putative 0.006 0.047 0.7538
Echinococcus granulosus Nuclear hormone receptor HR96 0.0039 0.0235 0.0188
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0073 0.0623 0.0811
Echinococcus multilocularis tar DNA binding protein 0.0334 0.3583 0.3522
Leishmania major glycosyl hydrolase-like protein 0.0027 0.01 0.1596
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0044 0.0289 0.0258
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0137 0.1346 0.1653
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0038 0.0222 0.0673
Loa Loa (eye worm) hypothetical protein 0.005 0.0358 0.0633
Brugia malayi Calcitonin receptor-like protein seb-1 0.005 0.0358 0.0633
Loa Loa (eye worm) hypothetical protein 0.0083 0.0736 0.1301
Echinococcus multilocularis histone acetyltransferase MYST2 0.0053 0.0386 0.0296
Trichomonas vaginalis glucosylceramidase, putative 0.0357 0.3847 0.6742
Echinococcus multilocularis phd:f box containing protein 0.0032 0.0156 0.0063
Schistosoma mansoni steroid hormone receptor ad4bp 0.0083 0.0736 0.0959
Echinococcus granulosus FTZ F1 alpha 0.0083 0.0736 0.0848
Schistosoma mansoni hypothetical protein 0.0034 0.0178 0.0232
Trichomonas vaginalis penicillin-binding protein, putative 0.0073 0.0623 0.0941
Trichomonas vaginalis set domain proteins, putative 0.0488 0.5336 0.9421
Loa Loa (eye worm) hypothetical protein 0.0044 0.0289 0.0511
Toxoplasma gondii ABC1 family protein 0.0073 0.0623 0.9983
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0083 0.0736 0.1301
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0038 0.0222 0.4719
Trypanosoma cruzi DNA polymerase kappa, putative 0.006 0.047 0.7538
Trichomonas vaginalis DNA polymerase eta, putative 0.006 0.047 0.0667
Trichomonas vaginalis ap endonuclease, putative 0.0038 0.0222 0.022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0073 0.0623 0.0534
Schistosoma mansoni sex comb on midleg homolog 0.0046 0.0314 0.0409
Loa Loa (eye worm) nuclear receptor NHR-67 0.0039 0.0235 0.0416
Brugia malayi nuclear hormone receptor family member nhr-6 0.0039 0.0235 0.0416
Loa Loa (eye worm) hypothetical protein 0.0062 0.0488 0.0862
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0039 0.0235 0.0271
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.3639 0.6369
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0062 0.0488 0.0635
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0039 0.0235 0.0144
Echinococcus multilocularis geminin 0.0358 0.3858 0.38
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0334 0.059
Brugia malayi jmjC domain containing protein 0.0121 0.1166 0.2061
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0039 0.0235 0.0307
Loa Loa (eye worm) hypothetical protein 0.0039 0.0235 0.0416
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.019 0.1946 0.187
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0038 0.0222 0.2334
Echinococcus multilocularis lysosomal alpha glucosidase 0.0331 0.3552 0.3491
Brugia malayi nuclear hormone receptor 0.0083 0.0736 0.1301
Mycobacterium tuberculosis Conserved protein 0.0073 0.0623 0.0819
Brugia malayi beta-lactamase 0.0073 0.0623 0.11
Echinococcus granulosus survival motor neuron protein 1 0.0235 0.2461 0.3124
Schistosoma mansoni microtubule-associated protein tau 0.0694 0.7672 1
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0073 0.0623 0.0819
Mycobacterium tuberculosis Probable esterase LipL 0.0073 0.0623 0.0819
Schistosoma mansoni RAR-like nuclear receptor 0.0083 0.0736 0.0959
Brugia malayi Glycosyl hydrolases family 31 protein 0.0027 0.01 0.0176
Brugia malayi tailless protein 0.0039 0.0235 0.0416
Schistosoma mansoni lamin 0.0027 0.0093 0.0122
Brugia malayi hypothetical protein 0.0039 0.0235 0.0416
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0038 0.0222 0.5
Loa Loa (eye worm) jmjC domain-containing protein 0.0032 0.0156 0.0275
Brugia malayi jmjC domain containing protein 0.0032 0.0156 0.0275

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 214 nM Displacement of [3H]SR141716A from CB1 receptor in rat cerebellum membrane ChEMBL. 19457667

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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