Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0018 | 0.0134 | 0.0145 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0022 | 0.079 | 0.0995 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0056 | 0.6845 | 0.6845 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0134 | 0.5 |
Schistosoma mansoni | bromodomain containing protein | 0.0062 | 0.7942 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0042 | 0.432 | 0.467 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0134 | 0.0168 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7314 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0056 | 0.6845 | 0.7401 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0056 | 0.6845 | 0.7401 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0056 | 0.6845 | 0.6845 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0038 | 0.3677 | 0.3677 |
Echinococcus multilocularis | zinc finger protein | 0.0019 | 0.0269 | 0.0368 |
Brugia malayi | Bromodomain containing protein | 0.0038 | 0.3556 | 0.3556 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0018 | 0.0134 | 0.5 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3141 | 0.4294 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0134 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3569 | 0.3858 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0018 | 0.0134 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0018 | 0.0134 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0059 | 0.7314 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.3984 | 0.4308 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0035 | 0.3141 | 0.4294 |
Schistosoma mansoni | zinc finger protein | 0.0019 | 0.0269 | 0.0339 |
Brugia malayi | PHD-finger family protein | 0.0024 | 0.1206 | 0.1206 |
Schistosoma mansoni | hypothetical protein | 0.002 | 0.0455 | 0.0572 |
Echinococcus multilocularis | fetal alzheimer antigen, falz | 0.0022 | 0.079 | 0.108 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0018 | 0.0134 | 0.0183 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0018 | 0.0134 | 0.5 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0018 | 0.0134 | 0.0183 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0018 | 0.0134 | 0.0134 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0018 | 0.0134 | 0.5 |
Echinococcus granulosus | fetal alzheimer antigen falz | 0.0022 | 0.079 | 0.108 |
Schistosoma mansoni | ap endonuclease | 0.0018 | 0.0134 | 0.0168 |
Toxoplasma gondii | exonuclease III APE | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0069 | 0.9249 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0038 | 0.3677 | 0.4629 |
Echinococcus granulosus | zinc finger protein | 0.0019 | 0.0269 | 0.0368 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.3677 | 0.3975 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0018 | 0.0134 | 0.5 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0018 | 0.0134 | 0.5 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0018 | 0.0134 | 0.5 |
Loa Loa (eye worm) | PHD-finger family protein | 0.002 | 0.0455 | 0.0491 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.