Detailed information for compound 1005239

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 452.569 | Formula: C24H28N4O3S
  • H donors: 1 H acceptors: 2 LogP: 2.94 Rotable bonds: 6
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1ccccc1N1CCN(CC1)CCCN1C(=O)NC2C(C1=O)Sc1c2cccc1
  • InChi: 1S/C24H28N4O3S/c1-31-19-9-4-3-8-18(19)27-15-13-26(14-16-27)11-6-12-28-23(29)22-21(25-24(28)30)17-7-2-5-10-20(17)32-22/h2-5,7-10,21-22H,6,11-16H2,1H3,(H,25,30)
  • InChiKey: DPQUATRKCICZPZ-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Mycobacterium ulcerans esterase/lipase LipP 0.0037 0.0062 0.0049
Loa Loa (eye worm) aspartic protease BmAsp-2 0.0034 0.0054 0.0054
Echinococcus multilocularis nicotinic acetylcholine receptor beta 1 subunit 0.0061 0.0132 0.0132
Mycobacterium ulcerans dihydrofolate reductase DfrA 0.3438 1 1
Echinococcus multilocularis thymidylate synthase 0.0332 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Onchocerca volvulus 0.0061 0.0132 0.0819
Toxoplasma gondii HEAT repeat-containing protein 0.006 0.0129 0.0251
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.002 0.0012 0.0012
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Schistosoma mansoni nicotinic acetylcholine receptor alpha 0.0033 0.005 0.005
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0129 0.0251
Brugia malayi Neuronal acetylcholine receptor protein, alpha-2 chain precursor 0.0028 0.0036 0.0036
Schistosoma mansoni bifunctional dihydrofolate reductase-thymidylate synthase 0.0332 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0057 0.0121 0.0108
Loa Loa (eye worm) neuronal acetylcholine receptor protein 0.0028 0.0036 0.0036
Echinococcus multilocularis neutral alpha glucosidase AB 0.008 0.0187 0.0187
Schistosoma mansoni ap endonuclease 0.002 0.0012 0.0012
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0019
Echinococcus multilocularis sodium:chloride dependent neurotransmitter 0.0084 0.0198 0.0198
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0096 0.0962
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0142 0.013
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0044 0.0083 0.0083
Onchocerca volvulus 0.0084 0.0198 0.1302
Echinococcus granulosus microtubule associated protein 2 0.0693 0.198 0.198
Echinococcus multilocularis cathepsin d (lysosomal aspartyl protease) 0.0034 0.0054 0.0054
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0083 0.0161
Loa Loa (eye worm) hypothetical protein 0.0032 0.0046 0.0046
Mycobacterium ulcerans thymidylate synthase 0.0332 0.0923 0.0912
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Leishmania major glycosyl hydrolase-like protein 0.003 0.0041 0.0079
Echinococcus multilocularis nAChR subunit 0.0033 0.005 0.005
Brugia malayi aspartic protease BmAsp-1, identical 0.0034 0.0054 0.0054
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0492 0.1392 0.1392
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0385
Echinococcus multilocularis serotonin transporter 0.0492 0.1392 0.1392
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.0132 0.0132
Trichomonas vaginalis importin beta-1, putative 0.0049 0.0096 0.0962
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0062
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Brugia malayi beta-lactamase 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0022 0.0019 0.0007
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0054 0.0105
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0146 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0022 0.0019 0.0007
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0054 0.0054
Brugia malayi hypothetical protein 0.0084 0.0198 0.0198
Plasmodium falciparum plasmepsin III 0.0034 0.0054 0.0105
Plasmodium falciparum plasmepsin X 0.0034 0.0054 0.0105
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Trichomonas vaginalis ran, putative 0.0044 0.0083 0.0811
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.002 0.0012 0.0012
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Brugia malayi Pepsin A precursor 0.0034 0.0054 0.0054
Brugia malayi acetylcholine receptor alpha subunit precursor, putative 0.0061 0.0132 0.0132
Echinococcus multilocularis nAChR subunit 0.0061 0.0132 0.0132
Plasmodium falciparum plasmepsin VI 0.0034 0.0054 0.0105
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.036 0.1005 0.1005
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0044 0.0083 0.2691
Echinococcus multilocularis synaptic vesicular amine transporter 0.0614 0.1747 0.1747
Loa Loa (eye worm) GABA receptor subunit 0.0033 0.005 0.005
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.002 0.0012 0.5
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0022 0.0019 0.0007
Onchocerca volvulus 0.0033 0.005 0.0221
Schistosoma mansoni nAChR subunit 0.0028 0.0036 0.0036
Echinococcus multilocularis dihydrofolate reductase 0.3438 1 1
Schistosoma mansoni hypothetical protein 0.0032 0.0047 0.0047
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0048 0.0096 0.0096
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0022 0.0019 0.0019
Schistosoma mansoni sodium/chloride dependent transporter 0.0084 0.0199 0.0199
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0187 0.2017
Schistosoma mansoni alpha-glucosidase 0.031 0.0859 0.0859
Echinococcus granulosus sodium:chloride dependent neurotransmitter 0.0084 0.0198 0.0198
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0111 0.0111
Brugia malayi Sodium:neurotransmitter symporter family protein 1, putative 0.0084 0.0198 0.0198
Onchocerca volvulus 0.0034 0.0054 0.0253
Echinococcus granulosus beta LACTamase domain containing family member 0.0037 0.0062 0.0062
Brugia malayi hypothetical protein 0.0158 0.0415 0.0415
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Onchocerca volvulus 0.0061 0.0132 0.0819
Echinococcus multilocularis importin subunit beta 1 0.006 0.0129 0.0129
Loa Loa (eye worm) serotonin transporter b 0.0492 0.1392 0.1392
Brugia malayi Calcitonin receptor-like protein seb-1 0.0101 0.0248 0.0248
Loa Loa (eye worm) solute carrier family 6 member 4 0.0492 0.1392 0.1392
Giardia lamblia Kinase, PLK 0.0109 0.0274 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0064 0.0142 0.0142
Loa Loa (eye worm) nicotinic acetylcholine receptor alpha subunit 0.0061 0.0132 0.0132
Echinococcus granulosus synaptic vesicular amine transporter 0.0614 0.1747 0.1747
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Plasmodium vivax hypothetical protein, conserved 0.0084 0.0198 0.0385
Echinococcus multilocularis gamma aminobutyric acid receptor subunit 0.0028 0.0036 0.0036
Trypanosoma brucei acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Brugia malayi serine/threonine-protein kinase plk-2 0.0109 0.0274 0.0274
Onchocerca volvulus 0.0061 0.0132 0.0819
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0022 0.0019 0.0019
Plasmodium falciparum plasmepsin II 0.0034 0.0054 0.0105
Echinococcus multilocularis nicotinic acetylcholine receptor a11 subunit 0.0061 0.0132 0.0132
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0062 0.0569
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0397 0.0397
Onchocerca volvulus Serine\/threonine kinase homolog 0.0109 0.0274 0.1852
Schistosoma mansoni nAChR subunit (ShAR1-beta-like) 0.0061 0.0132 0.0132
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.008 0.0187 0.2017
Schistosoma mansoni vesicular amine transporter 0.0614 0.1747 0.1747
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0019 0.0019
Entamoeba histolytica hypothetical protein 0.0074 0.017 0.6049
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Schistosoma mansoni voltage-gated potassium channel 0.004 0.007 0.007
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0177 0.0177
Toxoplasma gondii hypothetical protein 0.0084 0.0198 0.0385
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0076 0.0177 0.0177
Loa Loa (eye worm) acetylcholine receptor alpha subunit 0.0061 0.0132 0.0132
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Echinococcus granulosus GTP binding nuclear protein Ran 0.0044 0.0083 0.0083
Plasmodium vivax aspartyl protease, putative 0.0034 0.0054 0.0105
Loa Loa (eye worm) aspartyl protease 6 0.0034 0.0054 0.0054
Schistosoma mansoni serine/threonine protein kinase 0.0109 0.0274 0.0274
Brugia malayi hypothetical protein 0.0034 0.0054 0.0054
Schistosoma mansoni sodium/chloride dependent transporter 0.0084 0.0198 0.0198
Schistosoma mansoni hypothetical protein 0.0909 0.261 0.261
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0022 0.0019 0.0019
Onchocerca volvulus 0.0028 0.0036 0.0121
Echinococcus granulosus nicotinic acetylcholine receptor a11 subunit 0.0061 0.0132 0.0132
Trypanosoma cruzi importin beta-1 subunit, putative 0.0049 0.0096 0.0186
Brugia malayi hypothetical protein 0.0034 0.0054 0.0054
Schistosoma mansoni ran 0.0044 0.0083 0.0083
Echinococcus granulosus potassium voltage gated channel subfamily H 0.0036 0.0061 0.0061
Mycobacterium ulcerans lipase LipD 0.0037 0.0062 0.0049
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0019 0.0019
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.002 0.0012 0.0024
Brugia malayi Glycosyl hydrolases family 31 protein 0.008 0.0187 0.0187
Echinococcus granulosus geminin 0.0909 0.261 0.261
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0047 0.0047
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0054 0.0476
Toxoplasma gondii hypothetical protein 0.0084 0.0198 0.0385
Loa Loa (eye worm) hypothetical protein 0.003 0.0041 0.0041
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0177 0.0177
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0569
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0198
Entamoeba histolytica hypothetical protein 0.0033 0.005 0.1437
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Brugia malayi excitatory GABA receptor EXP-1A 0.0061 0.0132 0.0132
Onchocerca volvulus 0.0037 0.0062 0.0307
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Trichomonas vaginalis glutaminase, putative 0.0317 0.0879 1
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.002 0.0012 0.0024
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0033 0.005 0.005
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0047 0.0047
Brugia malayi Eukaryotic aspartyl protease family protein 0.0034 0.0054 0.0054
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0187 0.2017
Plasmodium vivax plasmepsin IV, putative 0.0034 0.0054 0.0105
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase 0.1774 0.5138 1
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Echinococcus multilocularis potassium voltage gated channel subfamily H 0.0036 0.0061 0.0061
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0019 0.0019
Echinococcus granulosus nicotinic acetylcholine receptor subunit type 0.0061 0.0132 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Schistosoma mansoni sodium/chloride dependent transporter 0.0492 0.1392 0.1392
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0012 0.0024
Plasmodium falciparum plasmepsin IV 0.0034 0.0054 0.0105
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Brugia malayi acetylcholine receptor, alpha-type subunit unc-38 precursor 0.0061 0.0132 0.0132
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0074 0.017 0.017
Echinococcus multilocularis snurportin 1 0.0639 0.182 0.182
Plasmodium vivax aspartyl proteinase, putative 0.0034 0.0054 0.0105
Brugia malayi nicotinic acetylcholine receptor alpha subunit, putative 0.0061 0.0132 0.0132
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0044 0.0083 0.0083
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0076 0.0177 0.0165
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Echinococcus granulosus glycine receptor subunit beta 0.0061 0.0132 0.0132
Echinococcus multilocularis sodium and chloride dependent glycine 0.0084 0.0198 0.0198
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0132 0.0132
Trypanosoma brucei hypothetical protein, conserved 0.0037 0.0062 0.012
Mycobacterium tuberculosis PROBABLE FATTY-ACID-CoA LIGASE FADD18 (FRAGMENT) (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0019 0.001 0.001
Onchocerca volvulus Uncharacterized family 31 glucosidase KIAA1161 homolog 0.003 0.0041 0.0156
Loa Loa (eye worm) glycosyl hydrolase family 31 protein 0.008 0.0187 0.0187
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0177 0.63
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0054
Schistosoma mansoni sodium-dependent amino acid transporter 0.0084 0.0198 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Toxoplasma gondii aldehyde dehydrogenase 0.0064 0.0142 0.0277
Onchocerca volvulus 0.0034 0.0054 0.0253
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0112 0.1153
Schistosoma mansoni acetylcholine receptor-related 0.0028 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0177 0.0165
Brugia malayi thymidylate synthase 0.0332 0.0923 0.0923
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.002 0.0012 0.0024
Mycobacterium leprae Probable lipase LipE 0.0037 0.0062 0.0042
Mycobacterium tuberculosis Probable thymidylate synthase ThyA (ts) (TSASE) 0.0332 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Echinococcus multilocularis GPCR, family 2 0.0032 0.0047 0.0047
Toxoplasma gondii aspartyl protease 0.0034 0.0054 0.0105
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0084 0.0198 0.0198
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0048 0.0096 0.0555
Brugia malayi glutamate-gated chloride channel alpha3A subunit, putative 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0121
Echinococcus multilocularis acetylcholine receptor subunit beta 1 0.0061 0.0132 0.0132
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Loa Loa (eye worm) ACC-1 protein 0.0061 0.0132 0.0132
Brugia malayi aspartic protease BmAsp-2, identical 0.0034 0.0054 0.0054
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0022 0.0019 0.0007
Brugia malayi RNA recognition motif domain containing protein 0.0146 0.0381 0.0381
Echinococcus granulosus GPCR family 2 0.0032 0.0047 0.0047
Brugia malayi Dihydrofolate reductase 0.3438 1 1
Loa Loa (eye worm) hypothetical protein 0.006 0.0129 0.0129
Echinococcus multilocularis uncharacterized sodium dependent transporter 0.0084 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0385
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0187 0.2017
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Mycobacterium ulcerans beta-lactamase 0.0037 0.0062 0.0049
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0142 0.0142
Schistosoma mansoni transcription factor LCR-F1 0.0074 0.017 0.017
Echinococcus granulosus tar DNA binding protein 0.0146 0.0381 0.0381
Echinococcus granulosus survival motor neuron protein 1 0.0238 0.0648 0.0648
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0074 0.017 0.017
Echinococcus granulosus serotonin transporter 0.0492 0.1392 0.1392
Plasmodium vivax acyl-CoA synthetase, putative 0.0057 0.0121 0.0235
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0492 0.1392 0.1392
Echinococcus multilocularis neuronal acetylcholine receptor subunit alpha 4 0.0061 0.0132 0.0132
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Echinococcus multilocularis nicotinic acetylcholine receptor subunit alpha 8 0.0061 0.0132 0.0132
Schistosoma mansoni hypothetical protein 0.0032 0.0047 0.0047
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0041 0.0329
Echinococcus granulosus nicotinic acetylcholine receptor subunit alpha 8 0.0061 0.0132 0.0132
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) ACC-1 protein 0.0061 0.0132 0.0132
Brugia malayi acetyl-Coenzyme A synthetase 2 0.0022 0.0019 0.0019
Echinococcus granulosus thymidylate synthase 0.0332 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0121
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0132 0.0132
Trypanosoma brucei glycosyl hydrolase-like protein 0.003 0.0041 0.0079
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0044 0.0083 0.0161
Loa Loa (eye worm) hypothetical protein 0.0076 0.0177 0.0177
Echinococcus granulosus dihydrofolate reductase 0.3438 1 1
Schistosoma mansoni acetyl-CoA synthetase 0.0022 0.0019 0.0019
Chlamydia trachomatis Ssodium-dependent amino acid transporter 0.0084 0.0198 0.0078
Toxoplasma gondii glycosyl hydrolase, family 31 protein 0.008 0.0187 0.0364
Onchocerca volvulus 0.0492 0.1392 1
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0101 0.0248 0.0248
Loa Loa (eye worm) thymidylate synthase 0.0332 0.0923 0.0923
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Onchocerca volvulus 0.0084 0.0198 0.1302
Plasmodium falciparum plasmepsin I 0.0034 0.0054 0.0105
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Schistosoma mansoni nAChR subunit (ShAR1-alpha-like) 0.0061 0.0132 0.0132
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) abnormal catecholamine distribution protein 1 0.0614 0.1747 0.1747
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Trypanosoma brucei glucosidase, putative 0.008 0.0187 0.0364
Echinococcus granulosus neutral alpha glucosidase AB 0.008 0.0187 0.0187
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0121
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0041 0.0329
Leishmania major alpha glucosidase II subunit, putative 0.008 0.0187 0.0364
Schistosoma mansoni hypothetical protein 0.0639 0.182 0.182
Mycobacterium tuberculosis Probable lipase LipD 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0121
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0177 0.0158
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.003 0.0041 0.1092
Loa Loa (eye worm) hypothetical protein 0.0032 0.0047 0.0047
Onchocerca volvulus 0.0332 0.0923 0.6585
Brugia malayi exodeoxyribonuclease III family protein 0.002 0.0012 0.0012
Loa Loa (eye worm) Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0198
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0022 0.0019 0.0007
Mycobacterium ulcerans hypothetical protein 0.0037 0.0062 0.0049
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0109 0.0274 0.0274
Echinococcus multilocularis lysosomal alpha glucosidase 0.036 0.1005 0.1005
Entamoeba histolytica hypothetical protein 0.0074 0.017 0.6049
Onchocerca volvulus 0.0028 0.0036 0.0121
Schistosoma mansoni hypothetical protein 0.0074 0.017 0.017
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0109 0.0274 0.0533
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.0132 0.0132
Plasmodium falciparum amino acid transporter, putative 0.0084 0.0198 0.0385
Schistosoma mansoni nAChR subunit 0.0028 0.0036 0.0036
Echinococcus granulosus acetylcholine receptor subunit beta 1 0.0061 0.0132 0.0132
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0047 0.0047
Leishmania major acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0057 0.0121 0.0121
Brugia malayi hypothetical protein 0.0074 0.017 0.017
Schistosoma mansoni survival motor neuron protein 0.0048 0.0096 0.0096
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0084 0.0198 0.0198
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0569
Echinococcus granulosus uncharacterized sodium dependent transporter 0.0084 0.0198 0.0198
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0022 0.0019 0.0019
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0381 0.0381
Brugia malayi latrophilin 2 splice variant baaae 0.0069 0.0155 0.0155
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0061 0.0132 0.0132
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Echinococcus multilocularis Cys loop ligand gated ion channel subunit 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0198
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Trypanosoma cruzi dihydrofolate reductase-thymidylate synthase, putative 0.0158 0.0415 0.0808
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0061 0.0132 0.0132
Trichomonas vaginalis maltase-glucoamylase, putative 0.003 0.0041 0.0329
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.008 0.0187 0.669
Schistosoma mansoni hypothetical protein 0.0032 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0238 0.0648 0.0648
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0044 0.0083 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0076 0.0177 0.0165
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0639 0.182 0.182
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0019 0.0038
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.0132 0.0132
Schistosoma mansoni nAChR subunit 0.0061 0.0132 0.0132
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Schistosoma mansoni memapsin-2 (A01 family) 0.0444 0.1251 0.1251
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0177 0.0344
Plasmodium falciparum plasmepsin V 0.0034 0.0054 0.0105
Echinococcus granulosus gamma aminobutyric acid receptor subunit 0.0028 0.0036 0.0036
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0177 0.0165
Plasmodium falciparum plasmepsin VIII, putative 0.0034 0.0054 0.0105
Leishmania major dihydrofolate reductase-thymidylate synthase 0.1774 0.5138 1
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0381 0.0381
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0022 0.0019 0.0038
Plasmodium vivax amine transporter, putative 0.0084 0.0198 0.0385
Leishmania major importin beta-1 subunit, putative 0.0049 0.0096 0.0186
Plasmodium vivax aspartyl protease, putative 0.0034 0.0054 0.0105
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0397 0.0397
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0037 0.0062 0.0062
Onchocerca volvulus 0.0061 0.0132 0.0819
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0177 0.0344
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0062 0.0062
Mycobacterium leprae DIHYDROFOLATE REDUCTASE DFRA (DHFR) (TETRAHYDROFOLATE DEHYDROGENASE) 0.3438 1 1
Onchocerca volvulus 0.0061 0.0132 0.0819
Loa Loa (eye worm) oxidoreductase 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0022 0.0019 0.0019
Brugia malayi Glycosyl hydrolases family 31 protein 0.036 0.1005 0.1005
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0076 0.0177 0.0177
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Loa Loa (eye worm) RNA binding protein 0.0146 0.0381 0.0381
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Schistosoma mansoni cathepsin D (A01 family) 0.0034 0.0054 0.0054
Plasmodium vivax aspartyl protease, putative 0.0034 0.0054 0.0105
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0076 0.0177 0.0165
Loa Loa (eye worm) beta-lactamase 0.0037 0.0062 0.0062
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0019 0.0083
Trichomonas vaginalis maltase-glucoamylase, putative 0.008 0.0187 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0397 0.0397
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0041 0.0329
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0044 0.0083 0.0161
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.002 0.0012 0.0012
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0235 0.0641 0.0641
Brugia malayi nicotinic acetylcholine receptor beta-1 chain precursor 0.0061 0.0132 0.0132
Schistosoma mansoni glutaminase 0.0317 0.0879 0.0879
Trichomonas vaginalis Clan AA, family A1, cathepsin D-like aspartic peptidase 0.0034 0.0054 0.0483
Echinococcus granulosus nAChR subunit 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Brugia malayi acetylcholine receptor protein, alpha-like chain, putative 0.0061 0.0132 0.0132
Schistosoma mansoni kinase 0.0056 0.0116 0.0116
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0109 0.0274 0.0274
Trichomonas vaginalis antibiotic synthetase, putative 0.0022 0.0019 0.0083
Plasmodium falciparum acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0037 0.0062 0.0062
Brugia malayi Acetylcholine receptor protein, alpha-like chain 1 precursor 0.0028 0.0036 0.0036
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0061 0.0132 0.0132
Echinococcus multilocularis tar DNA binding protein 0.0146 0.0381 0.0381
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0492 0.1392 0.1392
Entamoeba histolytica hypothetical protein 0.0049 0.0096 0.3191
Brugia malayi glutaminase DH11.1 0.0317 0.0879 0.0879
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0061 0.0132 0.0132
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0152 0.0397 0.0397
Mycobacterium ulcerans acyl-CoA synthetase 0.0076 0.0177 0.0165
Loa Loa (eye worm) hypothetical protein 0.0069 0.0155 0.0155
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0022 0.0019 0.0019
Loa Loa (eye worm) LGC-31 protein 0.0061 0.0132 0.0132
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0152 0.0397 0.0397
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0037 0.0062 0.0049
Toxoplasma gondii ABC1 family protein 0.0037 0.0062 0.012
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0187 0.0364
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.0132 0.0132
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0047 0.0047
Schistosoma mansoni ran 0.0044 0.0083 0.0083
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Plasmodium falciparum transporter, putative 0.0084 0.0198 0.0385
Brugia malayi Cation transporter family protein 0.0061 0.0132 0.0132
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Echinococcus multilocularis sodium and chloride dependent glycine 0.0084 0.0198 0.0198
Schistosoma mansoni dihydrofolate reductase 0.3438 1 1
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0022 0.0019 0.0274
Leishmania major hypothetical protein, conserved 0.0037 0.0062 0.012
Brugia malayi TAR-binding protein 0.0146 0.0381 0.0381
Brugia malayi hypothetical protein 0.0028 0.0036 0.0036
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.003 0.0041 0.0079
Entamoeba histolytica acyl-CoA synthetase, putative 0.0076 0.0177 0.63
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0062 0.012
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0101 0.0248 0.0248
Loa Loa (eye worm) glutaminase 2 0.0317 0.0879 0.0879
Mycobacterium tuberculosis Hypothetical protein 0.0158 0.0415 0.0415
Onchocerca volvulus Putative nachr subunit 0.0061 0.0132 0.0819
Trichomonas vaginalis conserved hypothetical protein 0.0158 0.0415 0.4647
Mycobacterium tuberculosis Probable hydrolase 0.0037 0.0062 0.0062
Brugia malayi RNA binding protein 0.0146 0.0381 0.0381
Toxoplasma gondii propionate-CoA ligase 0.0022 0.0019 0.0038
Trichomonas vaginalis D-aminoacylase, putative 0.0037 0.0062 0.0569
Schistosoma mansoni norepinephrine/norepinephrine transporter 0.0084 0.0198 0.0198
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Schistosoma mansoni sodium/chloride dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Brugia malayi hypothetical protein 0.0238 0.0648 0.0648
Trypanosoma brucei dihydrofolate reductase-thymidylate synthase 0.1774 0.5138 1
Toxoplasma gondii exonuclease III APE 0.002 0.0012 0.0024
Loa Loa (eye worm) voltage and ligand gated potassium channel 0.0036 0.0061 0.0061
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Schistosoma mansoni microtubule-associated protein tau 0.0693 0.198 0.198
Echinococcus granulosus sodium dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Schistosoma mansoni subfamily A1A unassigned peptidase (A01 family) 0.0034 0.0054 0.0054
Chlamydia trachomatis dihydrofolate reductase 0.3438 1 1
Echinococcus multilocularis survival motor neuron protein 1 0.0238 0.0648 0.0648
Entamoeba histolytica glycosyl hydrolase, family 31 protein 0.008 0.0187 0.669
Echinococcus granulosus lysosomal alpha glucosidase 0.036 0.1005 0.1005
Plasmodium falciparum bifunctional dihydrofolate reductase-thymidylate synthase 0.1774 0.5138 1
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0187 0.2017
Loa Loa (eye worm) hypothetical protein 0.0084 0.0198 0.0198
Onchocerca volvulus 0.0061 0.0132 0.0819
Schistosoma mansoni aldehyde dehydrogenase 0.0064 0.0142 0.0142
Schistosoma mansoni nAChR subunit (ShAR1-beta2-like) 0.0061 0.0132 0.0132
Trypanosoma cruzi hypothetical protein, conserved 0.008 0.0187 0.0364
Echinococcus multilocularis nicotinic acetylcholine receptor alpha subunit 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0064 0.0142 0.0277
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0142 0.013
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0041 0.0329
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Brugia malayi AMP-binding enzyme family protein 0.0076 0.0177 0.0177
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Mycobacterium tuberculosis Dihydrofolate reductase DfrA (DHFR) (tetrahydrofolate dehydrogenase) 0.3438 1 1
Plasmodium vivax hypothetical protein, conserved 0.0037 0.0062 0.012
Loa Loa (eye worm) nicotinic acetylcholine receptor non-alpha subunit 0.0061 0.0132 0.0132
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Entamoeba histolytica serine/threonine protein kinase, putative 0.0109 0.0274 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Brugia malayi Abnormal catecholamine distribution protein 1 0.0614 0.1747 0.1747
Plasmodium falciparum plasmepsin VII 0.0034 0.0054 0.0105
Mycobacterium tuberculosis Probable esterase LipL 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Mycobacterium ulcerans acetyl-CoA synthetase 0.0022 0.0019 0.0007
Mycobacterium ulcerans aldehyde dehydrogenase 0.0064 0.0142 0.013
Trichomonas vaginalis penicillin-binding protein, putative 0.0037 0.0062 0.0569
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0111 0.0111
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0044 0.0083 0.0161
Echinococcus granulosus zinc finger transcription factor gli2 0.0309 0.0856 0.0856
Plasmodium vivax acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Schistosoma mansoni sodium-dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.008 0.0187 0.2017
Plasmodium vivax plasmepsin V, putative 0.0034 0.0054 0.0105
Toxoplasma gondii eukaryotic aspartyl protease superfamily protein 0.0034 0.0054 0.0105
Brugia malayi gamma-aminobutyric-acid receptor beta subunit precursor 0.0061 0.0132 0.0132
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0044 0.0083 0.0083
Echinococcus granulosus snurportin 1 0.0639 0.182 0.182
Entamoeba histolytica acyl-coA synthetase, putative 0.0076 0.0177 0.63
Brugia malayi Cation transporter family protein 0.0061 0.0132 0.0132
Treponema pallidum sodium- and chloride- dependent transporter 0.0492 0.1392 1
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0054
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0198
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0041 0.0329
Trypanosoma brucei long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0019 0.0038
Leishmania major 4-coumarate:coa ligase-like protein 0.0076 0.0177 0.0344
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.002 0.0012 0.0024
Echinococcus multilocularis microtubule associated protein 2 0.0693 0.198 0.198
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0274 0.0533
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Brugia malayi beta-lactamase family protein 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Brugia malayi Zinc finger, C2H2 type family protein 0.0309 0.0856 0.0856
Plasmodium falciparum importin beta, putative 0.006 0.0129 0.0251
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Entamoeba histolytica Ran family GTPase 0.0044 0.0083 0.2691
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.005 0.005
Trichomonas vaginalis alpha-glucosidase, putative 0.003 0.0041 0.0329
Echinococcus granulosus Cys loop ligand gated ion channel subunit 0.0028 0.0036 0.0036
Loa Loa (eye worm) ligand-Gated ion Channel family member 0.0061 0.0132 0.0132
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0037 0.0062 0.0062
Entamoeba histolytica hypothetical protein 0.0074 0.017 0.6049
Brugia malayi Hypothetical glycine receptor like protein T20B12.9 in chromosome III 0.0033 0.005 0.005
Trypanosoma cruzi hypothetical protein, conserved 0.0037 0.0062 0.012
Schistosoma mansoni ap endonuclease 0.002 0.0012 0.0012
Loa Loa (eye worm) acetylcholine receptor protein 0.0028 0.0036 0.0036
Leishmania major long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0019 0.0038
Echinococcus multilocularis lysosomal alpha glucosidase 0.036 0.1005 0.1005
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0049 0.0096 0.0962
Loa Loa (eye worm) glutaminase 0.0317 0.0879 0.0879
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0022 0.0019 0.0007
Trypanosoma brucei importin beta-1 subunit, putative 0.006 0.0129 0.0251
Brugia malayi RNA, U transporter 1 0.017 0.0451 0.0451
Echinococcus multilocularis geminin 0.0909 0.261 0.261
Trichomonas vaginalis CAMK family protein kinase 0.0054 0.0112 0.1153
Mycobacterium leprae conserved hypothetical protein 0.0037 0.0062 0.0042
Trichomonas vaginalis esterase, putative 0.0037 0.0062 0.0569
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0111 0.0111
Toxoplasma gondii aspartyl protease ASP1 0.0034 0.0054 0.0105
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Schistosoma mansoni voltage-gated potassium channel 0.004 0.007 0.007
Schistosoma mansoni hypothetical protein 0.0032 0.0047 0.0047
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Onchocerca volvulus 0.0076 0.0177 0.1148
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0397 0.0397
Loa Loa (eye worm) aspartic protease BmAsp-1 0.0034 0.0054 0.0054
Loa Loa (eye worm) dihydrofolate reductase 0.3438 1 1
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0033 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0101 0.0248 0.0248
Onchocerca volvulus 0.0033 0.005 0.0221
Echinococcus granulosus glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Onchocerca volvulus 0.0208 0.0562 0.3951
Onchocerca volvulus 0.0037 0.0062 0.0307
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0022 0.0019 0.0007
Mycobacterium leprae PROBABLE THYMIDYLATE SYNTHASE THYA (TS) (TSASE) 0.0332 0.0923 0.0906
Echinococcus multilocularis sodium dependent neurotransmitter transporter 0.0084 0.0198 0.0198
Loa Loa (eye worm) glutamate-gated chloride channel alpha3A subunit 0.0028 0.0036 0.0036
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0076 0.0177 0.0177
Trypanosoma cruzi polo-like protein kinase, putative 0.0109 0.0274 0.0533
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0022 0.0019 0.0019
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0076 0.0177 0.0158
Echinococcus multilocularis nicotinic acetylcholine receptor subunit type 0.0028 0.0036 0.0036
Schistosoma mansoni tar DNA-binding protein 0.0146 0.0381 0.0381
Echinococcus granulosus nicotinic acetylcholine receptor beta 1 subunit 0.0061 0.0132 0.0132
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.002 0.0012 0.0012
Mycobacterium tuberculosis Probable lipase LipE 0.0037 0.0062 0.0062
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0152 0.0397 0.0397
Trichomonas vaginalis CAMK family protein kinase 0.0109 0.0274 0.3015
Mycobacterium ulcerans hypothetical protein 0.0076 0.0177 0.0165
Brugia malayi Voltage-gated potassium channel, HERG (KCNH2)-related. C. elegans unc-103 ortholog 0.0036 0.0061 0.0061
Brugia malayi AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Trichomonas vaginalis sucrase-isomaltase, putative 0.008 0.0187 0.2017
Echinococcus granulosus neuronal acetylcholine receptor subunit alpha 4 0.0061 0.0132 0.0132
Trypanosoma cruzi long-chain-fatty-acid-CoA ligase, putative 0.0022 0.0019 0.0038
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0037 0.0062 0.0062
Echinococcus multilocularis glycine receptor subunit beta 0.0061 0.0132 0.0132
Leishmania major GTP-binding protein, putative 0.0044 0.0083 0.0161
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Schistosoma mansoni alpha-glucosidase 0.031 0.0859 0.0859
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0054 0.0111 0.0111
Trichomonas vaginalis neutral alpha-glucosidase ab precursor, putative 0.003 0.0041 0.0329
Toxoplasma gondii bifunctional dihydrofolate reductase-thymidylate synthase 0.1774 0.5138 1
Mycobacterium tuberculosis Conserved protein 0.0037 0.0062 0.0062
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0022 0.0019 0.0007
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.1675 0.4848 0.4848
Echinococcus granulosus sodium and chloride dependent glycine 0.0084 0.0198 0.0198
Loa Loa (eye worm) hypothetical protein 0.0028 0.0036 0.0036
Brugia malayi beta-lactamase family protein 0.0037 0.0062 0.0062
Loa Loa (eye worm) hypothetical protein 0.0492 0.1392 0.1392
Onchocerca volvulus 0.0084 0.0198 0.1302
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0064 0.0142 0.0142
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0022 0.0019 0.0019
Loa Loa (eye worm) zinc finger protein 0.0309 0.0856 0.0856
Toxoplasma gondii aspartyl protease ASP3 0.0034 0.0054 0.0105
Trypanosoma cruzi acetyl-CoA synthetase, putative 0.0022 0.0019 0.0038
Loa Loa (eye worm) TAR-binding protein 0.0146 0.0381 0.0381
Echinococcus multilocularis beta LACTamase domain containing family member 0.0037 0.0062 0.0062
Onchocerca volvulus 0.0028 0.0036 0.0121
Schistosoma mansoni importin beta-1 0.006 0.0129 0.0129
Onchocerca volvulus 0.0037 0.0062 0.0307
Schistosoma mansoni hypothetical protein 0.0909 0.261 0.261
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0047 0.0047
Plasmodium vivax bifunctional dihydrofolate reductase-thymidylate synthase, putative 0.1774 0.5138 1
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0076 0.0177 0.0165
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0037 0.0062 0.0062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Echinococcus granulosus sodium and chloride dependent glycine 0.0084 0.0198 0.0198
Brugia malayi Neurotransmitter-gated ion-channel transmembrane region family protein 0.0061 0.0132 0.0132
Trypanosoma cruzi glycosyl hydrolase-like protein, putative 0.003 0.0041 0.0079
Echinococcus granulosus nicotinic acetylcholine receptor alpha subunit 0.0061 0.0132 0.0132
Schistosoma mansoni neurotransmitter gated ion channel 0.0028 0.0036 0.0036
Plasmodium falciparum acyl-CoA synthetase 0.0057 0.0121 0.0235
Echinococcus granulosus nAChR subunit 0.0033 0.005 0.005
Schistosoma mansoni hypothetical protein 0.0069 0.0155 0.0155
Brugia malayi Cation transporter family protein 0.0061 0.0132 0.0132
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.002 0.0012 0.0024
Echinococcus multilocularis glycine receptor subunit alpha 1 0.0061 0.0132 0.0132
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0152 0.0397 0.0397
Mycobacterium ulcerans acyl-CoA synthetase 0.0022 0.0019 0.0007
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0037 0.0062 0.0062
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0022 0.0019 0.0019
Echinococcus granulosus importin subunit beta 1 0.006 0.0129 0.0129
Loa Loa (eye worm) excitatory GABA receptor EXP-1A 0.0061 0.0132 0.0132
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0044 0.0083 0.0161
Brugia malayi Glycosyl hydrolases family 31 protein 0.003 0.0041 0.0041
Trypanosoma brucei polo-like protein kinase 0.0109 0.0274 0.0533
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0057 0.0121 0.0121
Trichomonas vaginalis voltage and ligand gated potassium channel, putative 0.0034 0.0054 0.0476
Plasmodium vivax importin-beta 2, putative 0.006 0.0129 0.0251
Brugia malayi Sodium:neurotransmitter symporter family protein 0.0492 0.1392 0.1392
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Entamoeba histolytica hypothetical protein 0.0074 0.017 0.6049
Brugia malayi Neurotransmitter-gated ion-channel ligand binding domain containing protein 0.0028 0.0036 0.0036
Loa Loa (eye worm) norepinephrine transporter 0.0492 0.1392 0.1392
Schistosoma mansoni alpha glucosidase 0.008 0.0187 0.0187
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0022 0.0019 0.0019
Loa Loa (eye worm) hypothetical protein 0.0034 0.0054 0.0054
Toxoplasma gondii aspartyl proteinase (eimepsin), putative 0.0034 0.0054 0.0105
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Trichomonas vaginalis alpha-glucosidase, putative 0.008 0.0187 0.2017
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0109 0.0274 0.0274
Toxoplasma gondii Sodium:neurotransmitter symporter family protein 0.0084 0.0198 0.0385
Schistosoma mansoni neurotransmitter gated ion channel 0.0033 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0076 0.0177 0.0177
Schistosoma mansoni acetylcholine receptor subunit beta 0.0028 0.0036 0.0036
Toxoplasma gondii Acetyl-coenzyme A synthetase 2, putative 0.0022 0.0019 0.0038
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0047 0.0047
Mycobacterium ulcerans glutaminase 0.0317 0.0879 0.0868
Schistosoma mansoni hypothetical protein 0.0048 0.0096 0.0096
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0064 0.0142 0.0142
Plasmodium falciparum plasmepsin IX 0.0034 0.0054 0.0105
Loa Loa (eye worm) hypothetical protein 0.0033 0.005 0.005
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Echinococcus multilocularis zinc finger transcription factor gli2 0.0309 0.0856 0.0856
Schistosoma mansoni Cys-loop ligand gated ion channel subunit 0.0033 0.005 0.005
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0152 0.0397 0.0397
Loa Loa (eye worm) hypothetical protein 0.0061 0.0132 0.0132
Brugia malayi Importin beta-1 subunit 0.006 0.0129 0.0129
Echinococcus granulosus cathepsin d lysosomal aspartyl protease 0.0034 0.0054 0.0054

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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