Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Homo sapiens | cannabinoid receptor 2 (macrophage) | Starlite/ChEMBL | References |
Homo sapiens | cannabinoid receptor 1 (brain) | Starlite/ChEMBL | References |
Homo sapiens | butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | butyrylcholinesterase | 602 aa | 546 aa | 30.2 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | Carboxylesterase family protein | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | carboxylesterase | 0.0082 | 0.5 | 0.5 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | carboxylesterase 5A | 0.0082 | 0.5 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus granulosus | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Echinococcus multilocularis | acetylcholinesterase | 0.0082 | 0.5 | 0.5 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Activity (binding) | = 21.78 % | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells at 10 uM after 90 mins | ChEMBL. | 23164658 |
Activity (binding) | = 57.83 % | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells at 10 uM after 90 mins | ChEMBL. | 23164658 |
EC50 (binding) | = 6.95 uM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins | ChEMBL. | 23164658 |
EC50 (binding) | > 10 uM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins | ChEMBL. | 23164658 |
IC50 (binding) | = 0.28 uM | Inhibition of human serum BuchE after 20 mins by Ellman's method | ChEMBL. | 18419109 |
IC50 (binding) | = 32.6 uM | Inhibition of human recombinant AchE after 20 mins by Ellman's method | ChEMBL. | 18419109 |
Ki (binding) | = 2.8 uM | Displacement of [3H]CP-55940 from human recombinant CB1 receptor expressed in HEK293 cells after 90 mins | ChEMBL. | 23164658 |
Ki (binding) | > 10 uM | Displacement of [3H]CP-55940 from human recombinant CB2 receptor expressed in HEK293 cells after 90 mins | ChEMBL. | 23164658 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
2 literature references were collected for this gene.