Detailed information for compound 1005471

Basic information

Technical information
  • TDR Targets ID: 1005471
  • Name: (2S)-3-[(Z)-10-methyldodec-1-en-3-ynoxy]propa ne-1,2-diol
  • MW: 268.392 | Formula: C16H28O3
  • H donors: 2 H acceptors: 2 LogP: 4.08 Rotable bonds: 10
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCC(CCCCCC#C/C=C\OC[C@H](CO)O)C
  • InChi: 1S/C16H28O3/c1-3-15(2)11-9-7-5-4-6-8-10-12-19-14-16(18)13-17/h10,12,15-18H,3-5,7,9,11,13-14H2,1-2H3/b12-10-/t15?,16-/m0/s1
  • InChiKey: CRMYJHMHQKEGTQ-SKUFQGSASA-N  

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity

Obtained from network model

Ranking Plot


Putative Targets List


Species Potential target Raw Global Species
Trichomonas vaginalis heat shock protein, putative 0.0035 0.0168 0.1827
Toxoplasma gondii heat shock protein 90, putative 0.0035 0.0168 0.1271
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0468 0.0845
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0032 0.0126 0.0168
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0199 0.2065 0.2573
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0201 0.0248
Echinococcus granulosus heat shock protein 0.0035 0.0168 0.018
Mycobacterium ulcerans esterase/lipase LipP 0.0038 0.0195 0.2512
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Schistosoma mansoni heat shock protein 0.0035 0.0168 0.0207
Trypanosoma brucei metallo-peptidase, Clan MA(E) Family M1 0.0038 0.0197 0.1221
Mycobacterium tuberculosis Probable esterase LipL 0.0038 0.0195 0.0447
Loa Loa (eye worm) hypothetical protein 0.0049 0.0323 0.0401
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0038 0.0197 0.1403
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0055 0.0392 0.0486
Schistosoma mansoni nuclear receptor nhr-48 0.0055 0.0392 0.0486
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0168 0.1014
Brugia malayi jmjC domain containing protein 0.0098 0.0895 0.1667
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0055 0.0392 0.0368
Brugia malayi Bromodomain containing protein 0.0084 0.0729 0.1347
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0197 0.0172
Echinococcus multilocularis tar DNA binding protein 0.0192 0.199 0.197
Loa Loa (eye worm) beta-lactamase 0.0038 0.0195 0.0241
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0088 0.0783 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0055 0.0392 0.0459
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0038 0.0195 0.0319
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0038 0.0195 0.0241
Schistosoma mansoni steroid hormone receptor ad4bp 0.0116 0.1102 0.1372
Brugia malayi nuclear receptor NHR-88 0.0055 0.0392 0.0698
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0197 0.0172
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Loa Loa (eye worm) leukotriene A4 hydrolase 0.0711 0.8019 1
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0088 0.0783 1
Schistosoma mansoni hypothetical protein 0.0037 0.0184 0.0227
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0392 0.1971
Trypanosoma cruzi Aminopeptidase M1, putative 0.0038 0.0197 0.1403
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Schistosoma mansoni kinase 0.0049 0.0332 0.0411
Schistosoma mansoni aminopeptidase PILS (M01 family) 0.0038 0.0197 0.0243
Giardia lamblia Histone acetyltransferase GCN5 0.0079 0.0672 0.7398
Loa Loa (eye worm) PLK/PLK1 protein kinase 0.0096 0.0878 0.1093
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0116 0.1102 0.2065
Echinococcus granulosus polycomb protein SCMH1 0.0049 0.0323 0.0373
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0708
Loa Loa (eye worm) nuclear receptor NHR-67 0.0055 0.0392 0.0486
Loa Loa (eye worm) DR-78 0.0055 0.0392 0.0486
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Mycobacterium ulcerans aminopeptidase N PepN 0.0038 0.0197 0.2537
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0037 0.0183 0.0159
Echinococcus multilocularis leukotriene A 4 hydrolase 0.0711 0.8019 0.8014
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Brugia malayi isocitrate dehydrogenase 0.0032 0.0126 0.0187
Echinococcus granulosus mitogen activated protein kinase 11 0.0141 0.1401 0.1722
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0116 0.1102 0.108
Schistosoma mansoni serine/threonine protein kinase 0.0096 0.0878 0.1093
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0116 0.1102 0.1348
Schistosoma mansoni cytosol alanyl aminopeptidase (M01 family) 0.0038 0.0197 0.0243
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0102
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0053 0.0368 0.4744
Loa Loa (eye worm) hypothetical protein 0.0039 0.0212 0.0262
Loa Loa (eye worm) hypothetical protein 0.0027 0.0073 0.0089
Echinococcus granulosus nuclear receptor nhr 48 0.0055 0.0392 0.0459
Brugia malayi nuclear receptor RXR 0.0055 0.0392 0.0698
Echinococcus multilocularis musashi 0.0028 0.0079 0.0055
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0116 0.1102 0.108
Echinococcus multilocularis aminopeptidase N 0.0038 0.0197 0.0172
Brugia malayi hypothetical protein 0.0037 0.0184 0.0298
Echinococcus granulosus tumor protein p63 0.0367 0.4026 0.5004
Echinococcus multilocularis FTZ F1 alpha 0.0116 0.1102 0.108
Mycobacterium ulcerans heat shock protein 90 0.0028 0.0085 0.0841
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0032 0.0126 0.0708
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0116 0.1102 0.1372
Schistosoma mansoni hypothetical protein 0.0065 0.0513 0.0637
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0023 0.0025 0.0028
Schistosoma mansoni zinc finger protein 0.0055 0.0392 0.0486
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0116 0.1102 0.108
Echinococcus multilocularis zinc finger protein 0.0027 0.0073 0.0048
Loa Loa (eye worm) hypothetical protein 0.0049 0.0323 0.04
Echinococcus multilocularis lamin 0.0028 0.0079 0.0055
Brugia malayi mbt repeat family protein 0.0049 0.0323 0.0565
Onchocerca volvulus 0.0038 0.0195 0.073
Echinococcus granulosus aminopeptidase N 0.0038 0.0197 0.0215
Brugia malayi ecdysone receptor 0.0055 0.0392 0.0698
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0079 0.0096
Echinococcus multilocularis ecdysone induced protein 78C 0.0116 0.1102 0.108
Brugia malayi hypothetical protein 0.0061 0.0468 0.0845
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0177 0.1816 0.2262
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.069 1
Echinococcus multilocularis polycomb protein SCMH1 0.0049 0.0323 0.0299
Trypanosoma cruzi puromycin-sensitive aminopeptidase-like protein, putative 0.0038 0.0197 0.1403
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0116 0.1102 0.108
Brugia malayi TAR-binding protein 0.0192 0.199 0.3773
Echinococcus granulosus histone acetyltransferase KAT2B 0.0284 0.3053 0.3788
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.0708
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0199 0.2065 0.2552
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Brugia malayi conserved hypotetical protein 0.0055 0.0392 0.0698
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0105 0.0129
Trypanosoma cruzi metallo-peptidase, Clan MA(E) Family M1 0.0038 0.0197 0.1403
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0116 0.1102 0.1372
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0197 0.0322
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Echinococcus granulosus endoplasmin 0.0028 0.0085 0.0075
Loa Loa (eye worm) hypothetical protein 0.0061 0.0468 0.0581
Mycobacterium ulcerans hypothetical protein 0.0038 0.0195 0.2512
Schistosoma mansoni jumonji/arid domain-containing protein 0.0038 0.0201 0.0248
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0068 0.0548 0.0524
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0199 0.2065 0.2046
Brugia malayi tailless protein 0.0055 0.0392 0.0698
Loa Loa (eye worm) nuclear hormone receptor 0.0055 0.0392 0.0486
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0079 0.0096
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0116 0.1102 0.1372
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0061 0.0468 0.0581
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0195 0.2135
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0038 0.0195 0.0447
Schistosoma mansoni bromodomain containing protein 0.0072 0.059 0.0733
Loa Loa (eye worm) hypothetical protein 0.008 0.069 0.0858
Schistosoma mansoni hypothetical protein 0.0065 0.0513 0.0637
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0116 0.1102 0.2065
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0105 0.0129
Brugia malayi hypothetical protein 0.0055 0.0392 0.0698
Toxoplasma gondii ABC1 family protein 0.0038 0.0195 0.1651
Brugia malayi beta-lactamase family protein 0.0038 0.0195 0.0319
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0065 0.0513 0.0489
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0038 0.0197 0.1403
Leishmania major puromycin-sensitive aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0197 0.1221
Echinococcus granulosus SAM and MBT domain containing protein 0.0049 0.0323 0.0373
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0055 0.0392 0.0459
Brugia malayi acetyltransferase, GNAT family protein 0.0294 0.3176 0.6056
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Schistosoma mansoni endoplasmin 0.0035 0.0168 0.0207
Loa Loa (eye worm) hypothetical protein 0.0051 0.0353 0.0438
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0116 0.1102 0.2065
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0116 0.1102 0.1348
Trypanosoma brucei hypothetical protein, conserved 0.0038 0.0195 0.1209
Plasmodium vivax endoplasmin, putative 0.0035 0.0168 0.1271
Schistosoma mansoni tar DNA-binding protein 0.0192 0.199 0.2479
Brugia malayi ecdysteroid receptor 0.0116 0.1102 0.2065
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0141 0.1401 1
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0878 0.6269
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0028 0.0085 0.0075
Giardia lamblia PHD finger protein 15 0.003 0.0105 0.0258
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Echinococcus multilocularis peregrin 0.0039 0.0216 0.0192
Onchocerca volvulus Bile acid receptor homolog 0.0116 0.1102 0.6446
Loa Loa (eye worm) jmjC domain-containing protein 0.0038 0.0201 0.0248
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0392 0.0368
Schistosoma mansoni nuclear receptor 0.0055 0.0392 0.0486
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0085 0.0864
Brugia malayi heat shock protein 90 0.0035 0.0168 0.0268
Loa Loa (eye worm) hypothetical protein 0.0072 0.0595 0.074
Loa Loa (eye worm) hypothetical protein 0.003 0.0105 0.0129
Mycobacterium tuberculosis Conserved protein 0.0038 0.0195 0.0447
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0116 0.1102 0.1372
Leishmania major hypothetical protein, conserved 0.0038 0.0195 0.1209
Loa Loa (eye worm) hypothetical protein 0.0051 0.0346 0.0429
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0088 0.0783 1
Onchocerca volvulus 0.0038 0.0195 0.073
Trypanosoma brucei Heat shock protein 83, putative 0.0035 0.0168 0.1014
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0168 0.1201
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0197 0.0322
Loa Loa (eye worm) hypothetical protein 0.0061 0.0468 0.0581
Schistosoma mansoni protein kinase 0.008 0.0686 0.0853
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2065 0.2573
Plasmodium falciparum heat shock protein 90 0.0035 0.0168 0.2334
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Echinococcus multilocularis endoplasmin 0.0028 0.0085 0.006
Echinococcus granulosus histone acetyltransferase KAT2B 0.0088 0.0783 0.0948
Schistosoma mansoni myelin transcription factor 1 myt1 0.0055 0.0401 0.0497
Brugia malayi follicle stimulating hormone receptor 0.0471 0.5226 1
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1401 0.138
Brugia malayi photoreceptor-specific nuclear receptor 0.0116 0.1102 0.2065
Trypanosoma cruzi aminopeptidase, putative 0.0038 0.0197 0.1403
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.069 0.8675
Echinococcus granulosus FTZ F1 alpha 0.0116 0.1102 0.1348
Brugia malayi PHD-finger family protein 0.0033 0.0136 0.0205
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0102
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0199 0.2065 0.2046
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0116 0.1102 0.1372
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0127
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Echinococcus granulosus suppression of tumorigenicity 18 protein 0.0055 0.0401 0.047
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0055 0.0392 0.0368
Schistosoma mansoni nuclear hormone receptor 0.0116 0.1102 0.1372
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0294 0.3176 0.316
Loa Loa (eye worm) hypothetical protein 0.0055 0.0401 0.0497
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0197 0.2154
Loa Loa (eye worm) hypothetical protein 0.0068 0.0549 0.0682
Echinococcus multilocularis jumonji domain containing protein 0.0042 0.0241 0.0217
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0317 0.3539
Echinococcus granulosus jumonji domain containing protein 0.0042 0.0241 0.0271
Schistosoma mansoni leukotriene A4 hydrolase (M01 family) 0.0711 0.8019 1
Echinococcus granulosus endonuclease exonuclease phosphatase 0.0192 0.1983 0.245
Schistosoma mansoni cellular tumor antigen P53 0.0054 0.0382 0.0474
Loa Loa (eye worm) mbt repeat family protein 0.0049 0.0323 0.04
Loa Loa (eye worm) hypothetical protein 0.0065 0.0513 0.0637
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0294 0.3176 0.3959
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.069 0.0858
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0197 0.0172
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Entamoeba histolytica serine/threonine protein kinase, putative 0.0096 0.0878 1
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.069 0.0832
Brugia malayi Protein kinase domain containing protein 0.0069 0.0562 0.1025
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Echinococcus multilocularis tumor protein p63 0.0367 0.4026 0.4011
Echinococcus granulosus zinc finger protein 0.0027 0.0073 0.006
Brugia malayi protein C17H12.11 0.0068 0.0549 0.1001
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0116 0.1102 0.2065
Trypanosoma brucei heat shock protein 90, putative 0.0035 0.0168 0.1014
Entamoeba histolytica acetyltransferase, GNAT family 0.0079 0.0672 0.7091
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.069 0.5
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0195 0.1391
Brugia malayi Bromodomain containing protein 0.0039 0.0216 0.036
Loa Loa (eye worm) MBCTL1 0.0055 0.0401 0.0497
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0116 0.1102 0.2065
Loa Loa (eye worm) TKL/STKR/TYPE2 protein kinase 0.0069 0.0562 0.0698
Entamoeba histolytica hypothetical protein 0.0037 0.0184 0.0218
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0116 0.1102 0.1372
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.069 1
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0475 0.059
Onchocerca volvulus 0.0038 0.0195 0.073
Echinococcus multilocularis GPCR, family 2 0.0065 0.0513 0.0489
Echinococcus multilocularis heat shock protein 0.0035 0.0168 0.0144
Loa Loa (eye worm) follicle stimulating hormone receptor 0.0471 0.5226 0.6516
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Schistosoma mansoni nuclear receptor 0.0055 0.0392 0.0486
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0195 0.1651
Brugia malayi intermediate filament protein 0.0028 0.0079 0.0096
Echinococcus multilocularis activin receptor type 0.0081 0.0698 0.0675
Brugia malayi nuclear receptor RXR 0.0061 0.0468 0.0845
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0392 0.0698
Loa Loa (eye worm) hypothetical protein 0.0028 0.0079 0.0096
Brugia malayi nuclear hormone receptor 0.0055 0.0392 0.0698
Loa Loa (eye worm) bromodomain containing protein 0.0025 0.005 0.006
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Loa Loa (eye worm) heat shock protein 90 0.0035 0.0168 0.0207
Brugia malayi hypothetical protein 0.0038 0.0197 0.0322
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0038 0.0195 0.0447
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0038 0.0197 0.1674
Brugia malayi steroid hormone receptor 0.0116 0.1102 0.2065
Giardia lamblia Heat shock protein HSP 90-alpha 0.0035 0.0168 0.1053
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0028 0.0085 0.0405
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0116 0.1102 0.1348
Loa Loa (eye worm) endoplasmin 0.0035 0.0168 0.0207
Echinococcus granulosus activin receptor type 0.0081 0.0698 0.0842
Echinococcus granulosus geminin 0.0184 0.1898 0.2343
Loa Loa (eye worm) hypothetical protein 0.0205 0.2144 0.2672
Brugia malayi hypothetical protein 0.0164 0.1666 0.315
Plasmodium vivax heat shock protein 86, putative 0.0035 0.0168 0.1271
Brugia malayi hypothetical protein 0.0061 0.0468 0.0845
Loa Loa (eye worm) aminopeptidase N 0.0038 0.0197 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0392 0.0459
Trypanosoma cruzi heat shock protein 85, putative 0.0028 0.0085 0.0604
Brugia malayi P38 map kinase family protein 2 0.0141 0.1401 0.264
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0055 0.0392 0.0486
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Loa Loa (eye worm) acetyltransferase 0.0294 0.3176 0.3959
Trypanosoma cruzi heat shock protein 90, putative 0.0035 0.0168 0.1201
Brugia malayi Peptidase family M1 containing protein 0.0038 0.0197 0.0322
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0053 0.0368 0.1151
Entamoeba histolytica hypothetical protein 0.0037 0.0184 0.0218
Brugia malayi Isocitrate dehydrogenase 0.0032 0.0126 0.0187
Brugia malayi serine/threonine-protein kinase plk-2 0.0096 0.0878 0.1634
Brugia malayi Probable ClpP-like protease 0.008 0.069 0.1271
Brugia malayi Calcitonin receptor-like protein seb-1 0.0205 0.2144 0.4069
Brugia malayi C2-HC type zinc finger protein C.e-MyT1 0.0055 0.0401 0.0715
Echinococcus multilocularis serine:threonine protein kinase receptor R3 0.0081 0.0698 0.0675
Echinococcus granulosus lamin dm0 0.0028 0.0079 0.0068
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Brugia malayi Latrophilin receptor protein 2 0.0065 0.0513 0.0931
Onchocerca volvulus 0.0038 0.0197 0.0741
Loa Loa (eye worm) TATA binding protein associated factor 0.0038 0.0197 0.0243
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0088 0.0783 0.8902
Loa Loa (eye worm) hypothetical protein 0.0061 0.0468 0.0581
Echinococcus multilocularis peptidase Clp (S14 family) 0.0053 0.0368 0.0345
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0085 0.0864
Loa Loa (eye worm) MH2 domain-containing protein 0.013 0.1266 0.1576
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Plasmodium vivax M1-family alanyl aminopeptidase, putative 0.0038 0.0197 0.1674
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.069 1
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0195 0.2135
Loa Loa (eye worm) hypothetical protein 0.0061 0.0468 0.0581
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0065 0.0513 0.0931
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0116 0.1102 0.1348
Brugia malayi nuclear hormone receptor family member nhr-6 0.0055 0.0392 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0116 0.1102 0.2065
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.069 1
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Mycobacterium tuberculosis Probable lipase LipE 0.0038 0.0195 0.0447
Loa Loa (eye worm) hypothetical protein 0.0164 0.1666 0.2076
Schistosoma mansoni protein kinase 0.0178 0.1828 0.2278
Loa Loa (eye worm) steroid hormone receptor 0.0116 0.1102 0.1372
Schistosoma mansoni retinoic acid receptor RXR 0.0116 0.1102 0.1372
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.0673
Brugia malayi jmjC domain containing protein 0.0038 0.0201 0.033
Echinococcus granulosus lysine specific demethylase 5A 0.0038 0.0201 0.022
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0141 0.1401 0.1745
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0029 0.0207
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Brugia malayi PHD-finger family protein 0.003 0.0105 0.0146
Brugia malayi nuclear receptor NHR-88 0.0116 0.1102 0.2065
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Brugia malayi bone morphogenetic protein type 1 receptor 0.0177 0.1816 0.3438
Schistosoma mansoni intermediate filament proteins 0.0028 0.0079 0.0096
Brugia malayi nuclear hormone receptor 0.0116 0.1102 0.2065
Schistosoma mansoni aminopeptidase A (M01 family) 0.0038 0.0197 0.0243
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0197 0.2154
Echinococcus granulosus mitogen activated protein kinase 14 0.0141 0.1401 0.1722
Mycobacterium leprae Probable lipase LipE 0.0038 0.0195 0.1903
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Brugia malayi hypothetical protein 0.0038 0.0197 0.0322
Onchocerca volvulus 0.0164 0.1666 1
Loa Loa (eye worm) CYP4Cod1 0.0023 0.0029 0.0034
Echinococcus granulosus peregrin 0.0039 0.0216 0.024
Schistosoma mansoni heat shock protein 0.0035 0.0168 0.0207
Schistosoma mansoni hypothetical protein 0.0184 0.1898 0.2365
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0037 0.0184 0.0159
Mycobacterium ulcerans aminopeptidase N PepN 0.0038 0.0197 0.2537
Echinococcus granulosus TGF beta receptor type 1 0.0178 0.1828 0.2256
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Trichomonas vaginalis esterase, putative 0.0038 0.0195 0.2135
Toxoplasma gondii isocitrate dehydrogenase 0.0032 0.0126 0.0673
Schistosoma mansoni thyroid hormone receptor 0.0116 0.1102 0.1372
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.069 0.5
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0055 0.0392 0.0368
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0116 0.1102 0.6446
Onchocerca volvulus Protein ultraspiracle homolog 0.0116 0.1102 0.6446
Echinococcus multilocularis thyroid hormone receptor alpha 0.0116 0.1102 0.108
Echinococcus multilocularis Peptidase M1, membrane alanine aminopeptidase, N terminal 0.0038 0.0197 0.0172
Plasmodium falciparum phd finger protein, putative 0.003 0.0105 0.1405
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0468 0.0581
Loa Loa (eye worm) hypothetical protein 0.0061 0.0468 0.0581
Loa Loa (eye worm) hypothetical protein 0.0054 0.0382 0.0474
Schistosoma mansoni thyroid hormone receptor 0.0116 0.1102 0.1372
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0029 0.0034
Echinococcus multilocularis suppression of tumorigenicity 18 protein 0.0055 0.0401 0.0377
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0116 0.1102 0.1348
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0195 0.2135
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0197 0.1221
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0197 0.1221
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0061 0.0468 0.0444
Loa Loa (eye worm) TKL/STKR/TYPE1 protein kinase 0.0069 0.0562 0.0698
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0116 0.1102 0.2065
Trypanosoma cruzi heat shock protein 90, putative 0.0028 0.0085 0.0604
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0105 0.0081
Toxoplasma gondii aminopeptidase n, putative 0.0038 0.0197 0.1674
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0032 0.0126 0.1715
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.0895 0.1089
Plasmodium falciparum M1-family alanyl aminopeptidase, putative 0.0038 0.0197 0.2751
Echinococcus multilocularis endonuclease exonuclease phosphatase 0.0192 0.1983 0.1964
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Loa Loa (eye worm) peptidase family M1 containing protein 0.0038 0.0197 0.0243
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0243
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0105 0.0101
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0038 0.0195 0.0447
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0116 0.1102 0.1372
Schistosoma mansoni transcription factor LCR-F1 0.0037 0.0184 0.0227
Onchocerca volvulus 0.0055 0.0392 0.1971
Brugia malayi Nuclear hormone receptor E75 0.0055 0.0392 0.0698
Trypanosoma cruzi hypothetical protein, conserved 0.0038 0.0195 0.1391
Echinococcus multilocularis lamin dm0 0.0028 0.0079 0.0055
Giardia lamblia Kinase, PLK 0.0096 0.0878 1
Schistosoma mansoni coup transcription factor 0.0116 0.1102 0.1372
Trichomonas vaginalis CAMK family protein kinase 0.0048 0.0317 0.3539
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0116 0.1102 0.2065
Schistosoma mansoni hypothetical protein 0.0295 0.3191 0.3978
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0105 0.0374
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0105 0.0374
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2065 0.2573
Mycobacterium tuberculosis Probable lipase LipD 0.0038 0.0195 0.0447
Brugia malayi Cytochrome P450 family protein 0.0053 0.0377 0.067
Plasmodium falciparum M1-family alanyl aminopeptidase 0.0038 0.0197 0.2751
Brugia malayi RNA binding protein 0.0192 0.199 0.3773
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0197 0.1221
Trypanosoma brucei Aminopeptidase M1, putative 0.0038 0.0197 0.1221
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0116 0.1102 0.1372
Mycobacterium tuberculosis Conserved protein 0.0038 0.0195 0.0447
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0195 0.0241
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0116 0.1102 0.1348
Echinococcus granulosus lamin 0.0028 0.0079 0.0068
Schistosoma mansoni hypothetical protein 0.003 0.0105 0.0129
Leishmania major protein kinase, putative,polo-like protein kinase, putative 0.0096 0.0878 0.619
Echinococcus granulosus beta LACTamase domain containing family member 0.0038 0.0195 0.0213
Onchocerca volvulus 0.0054 0.0382 0.1911
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0038 0.0195 0.0241
Echinococcus granulosus histone acetyltransferase MYST2 0.0055 0.0401 0.047
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0032 0.0126 0.0102
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0032 0.0126 0.09
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0116 0.1102 0.1372
Brugia malayi beta-lactamase 0.0038 0.0195 0.0319
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Onchocerca volvulus 0.0116 0.1102 0.6446
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Trypanosoma cruzi Heat shock protein 83, putative 0.0035 0.0168 0.1201
Brugia malayi hypothetical protein 0.0327 0.3556 0.6787
Brugia malayi Bromodomain containing protein 0.0046 0.0294 0.051
Schistosoma mansoni tar DNA-binding protein 0.0192 0.199 0.2479
Leishmania major aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1 0.0038 0.0197 0.1221
Plasmodium vivax hypothetical protein, conserved 0.003 0.0105 0.0374
Echinococcus granulosus TGF-beta receptor type-1 0.0178 0.1828 0.2256
Brugia malayi Nuclear hormone receptor-like 1 0.0116 0.1102 0.2065
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0079 0.1018
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0032 0.0126 0.0155
Schistosoma mansoni scm-relatedprotein containing 4 mbt domains (sfmbt) 0.0049 0.0323 0.04
Mycobacterium ulcerans beta-lactamase 0.0038 0.0195 0.2512
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0116 0.1102 0.1372
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0065 0.0513 0.0489
Brugia malayi hypothetical protein 0.0055 0.0392 0.0698
Toxoplasma gondii heat shock protein HSP90 0.0035 0.0168 0.1271
Trichomonas vaginalis Clan MA, family M1, aminopeptidase N-like metallopeptidase 0.0038 0.0197 0.2154
Echinococcus multilocularis mitogen activated protein kinase 11 0.0141 0.1401 0.138
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Echinococcus multilocularis isocitrate dehydrogenase 0.0032 0.0126 0.0102
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0199 0.2065 0.2552
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0197 0.0172
Echinococcus multilocularis heat shock protein 90 0.0028 0.0085 0.006
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0116 0.1102 0.2065
Onchocerca volvulus 0.0038 0.0197 0.0741
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0116 0.1102 0.2065
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0065 0.0513 0.061
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.069 0.0667
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0055 0.0392 0.1971
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0141 0.1401 1
Echinococcus granulosus tar DNA binding protein 0.0192 0.199 0.2458
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0116 0.1102 0.2065
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.0895 0.0873
Schistosoma mansoni tar DNA-binding protein 0.0192 0.199 0.2479
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1401 1
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0116 0.1102 0.108
Onchocerca volvulus Alhambra homolog 0.003 0.0105 0.0164
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Brugia malayi Endoplasmin precursor 0.0035 0.0168 0.0268
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0116 0.1102 0.1372
Brugia malayi nuclear receptor NHR-67 0.0055 0.0392 0.0698
Schistosoma mansoni tar DNA-binding protein 0.0192 0.199 0.2479
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0032 0.0126 0.0102
Loa Loa (eye worm) TAR-binding protein 0.0192 0.199 0.2479
Entamoeba histolytica aminopeptidase, putative 0.0038 0.0197 0.04
Trypanosoma brucei heat shock protein, putative 0.0035 0.0168 0.1014
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0178 0.0154
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0068 0.0548 0.0654
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0061 0.0468 0.0581
Loa Loa (eye worm) cytochrome P450 family protein 0.0023 0.0029 0.0034
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0323 0.04
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0065 0.0513 0.061
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0116 0.1102 0.1372
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0032 0.0126 0.09
Schistosoma mansoni zinc finger protein 0.0027 0.0073 0.0088
Echinococcus granulosus thyroid hormone receptor alpha 0.0055 0.0392 0.0459
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1401 0.138
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0468 0.0845
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0205 0.2144 0.2672
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0055 0.0392 0.0368
Echinococcus granulosus puromycin sensitive aminopeptidase 0.0038 0.0197 0.0215
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0392 0.0486
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0028 0.0085 0.0096
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.069 0.8675
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0168 0.1201
Loa Loa (eye worm) hypothetical protein 0.0038 0.0195 0.0241
Brugia malayi TATA binding protein associated factor 0.0038 0.0197 0.0322
Brugia malayi latrophilin 2 splice variant baaae 0.014 0.1389 0.2617
Trypanosoma cruzi aminopeptidase, putative 0.0038 0.0197 0.1403
Trypanosoma brucei aminopeptidase, putative 0.0038 0.0197 0.1221
Trichomonas vaginalis D-aminoacylase, putative 0.0038 0.0195 0.2135
Loa Loa (eye worm) cytochrome P450 family protein 0.0053 0.0377 0.0468
Trypanosoma cruzi heat shock protein 85, putative 0.0035 0.0168 0.1201
Schistosoma mansoni hypothetical protein 0.014 0.1389 0.173
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0032 0.0126 0.0673
Loa Loa (eye worm) latrophilin receptor protein 2 0.0065 0.0513 0.0637
Echinococcus multilocularis nuclear receptor nhr 48 0.0055 0.0392 0.0368
Trichomonas vaginalis heat shock protein, putative 0.0028 0.0085 0.0864
Echinococcus multilocularis geminin 0.0184 0.1898 0.1878
Schistosoma mansoni Tata binding protein associated factor (M01 family) 0.0038 0.0197 0.0243
Trypanosoma brucei polo-like protein kinase 0.0096 0.0878 0.619
Echinococcus granulosus peptidase Clp S14 family 0.0053 0.0368 0.043
Echinococcus multilocularis mitogen activated protein kinase 14 0.0141 0.1401 0.138
Schistosoma mansoni lamin 0.0028 0.0079 0.0096
Brugia malayi beta-lactamase family protein 0.0038 0.0195 0.0319
Brugia malayi mbt repeat family protein 0.0049 0.0323 0.0565
Echinococcus multilocularis beta LACTamase domain containing family member 0.0038 0.0195 0.0171
Mycobacterium leprae conserved hypothetical protein 0.0038 0.0195 0.1903
Echinococcus granulosus leukotriene A 4 hydrolase 0.0711 0.8019 1
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Loa Loa (eye worm) hypothetical protein 0.0055 0.0392 0.0486
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Loa Loa (eye worm) hypothetical protein 0.014 0.1389 0.173
Mycobacterium ulcerans lipase LipD 0.0038 0.0195 0.2512
Trichomonas vaginalis penicillin-binding protein, putative 0.0038 0.0195 0.2135
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0116 0.1102 0.2065
Echinococcus multilocularis puromycin sensitive aminopeptidase 0.0038 0.0197 0.0172
Echinococcus granulosus heat shock protein 90 0.0035 0.0168 0.018
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0038 0.0195 0.2512
Mycobacterium tuberculosis Possible penicillin-binding protein 0.024 0.2551 1
Schistosoma mansoni hypothetical protein 0.0065 0.0513 0.0637
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0116 0.1102 0.1372
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0116 0.1102 0.108
Schistosoma mansoni endoplasmin 0.0035 0.0168 0.0207
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Loa Loa (eye worm) transcription factor SMAD2 0.013 0.1266 0.1576
Brugia malayi Steroid receptor seven-up type 2 0.0116 0.1102 0.2065
Trypanosoma cruzi cytochrome P450, putative 0.0023 0.0029 0.0207
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0079 0.0096
Loa Loa (eye worm) isocitrate dehydrogenase 0.0032 0.0126 0.0155
Onchocerca volvulus Polycomb protein Sfmbt homolog 0.0049 0.0323 0.1534
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0053 0.0368 0.1151
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Loa Loa (eye worm) hypothetical protein 0.0116 0.1102 0.1372
Echinococcus multilocularis heat shock protein 90 0.0035 0.0168 0.0144
Echinococcus multilocularis SAM and MBT domain containing protein 0.0049 0.0323 0.0299
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0243
Echinococcus granulosus Nuclear hormone receptor HR96 0.0055 0.0392 0.0459
Schistosoma mansoni hypothetical protein 0.0065 0.0513 0.0637
Entamoeba histolytica hypothetical protein 0.0037 0.0184 0.0218
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0037 0.0184 0.0199
Brugia malayi orphan nuclear receptor NR2E1 0.0055 0.0392 0.0698
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Trypanosoma cruzi polo-like protein kinase, putative 0.0096 0.0878 0.6269
Treponema pallidum heat shock protein 90 0.0028 0.0085 0.0096
Brugia malayi MH2 domain containing protein 0.013 0.1266 0.2379
Onchocerca volvulus Serine\/threonine kinase homolog 0.0096 0.0878 0.5035
Onchocerca volvulus 0.0049 0.0323 0.1534
Toxoplasma gondii aminopeptidase N protein 0.0038 0.0197 0.1674
Schistosoma mansoni sex comb on midleg homolog 0.0049 0.0323 0.04
Schistosoma mansoni lamin 0.0028 0.0079 0.0096
Brugia malayi RNA recognition motif domain containing protein 0.0192 0.199 0.3773
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Leishmania major heat shock protein 83-1 0.0035 0.0168 0.1014
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0061 0.0468 0.0555
Brugia malayi hypothetical protein 0.0068 0.0549 0.1001
Echinococcus granulosus ecdysone induced protein 78C 0.0116 0.1102 0.1348
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.069 0.8675
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0199 0.2065 0.2573
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.069 1
Mycobacterium tuberculosis Probable hydrolase 0.0038 0.0195 0.0447
Mycobacterium tuberculosis Conserved protein 0.0038 0.0195 0.0447
Toxoplasma gondii aminopeptidase N, putative 0.0038 0.0197 0.1674
Entamoeba histolytica hypothetical protein 0.0037 0.0184 0.0218
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0116 0.1102 0.2065
Trypanosoma cruzi metallo-peptidase, clan MA(E), family M1, putative 0.0038 0.0197 0.1403
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0055 0.0392 0.0698
Loa Loa (eye worm) hypothetical protein 0.0038 0.0197 0.0243
Echinococcus granulosus heat shock protein 90 0.0028 0.0085 0.0075
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0037 0.0183 0.0198
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0116 0.1102 0.1348
Schistosoma mansoni tar DNA-binding protein 0.0192 0.199 0.2479
Schistosoma mansoni nuclear hormone receptor 0.0055 0.0392 0.0486
Onchocerca volvulus 0.0055 0.0392 0.1971
Trichomonas vaginalis CAMK family protein kinase 0.0096 0.0878 1
Plasmodium falciparum histone acetyltransferase GCN5 0.0079 0.0672 0.9738
Echinococcus multilocularis serine:threonine protein kinase PLK1 0.0096 0.0878 0.0856
Onchocerca volvulus 0.0038 0.0197 0.0741
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0199 0.2065 0.3918
Echinococcus multilocularis histone acetyltransferase MYST2 0.0055 0.0401 0.0377
Echinococcus granulosus intermediate filament protein 0.0028 0.0079 0.0068
Trichomonas vaginalis bromodomain-containing protein, putative 0.0088 0.0783 0.8902
Loa Loa (eye worm) RNA binding protein 0.0192 0.199 0.2479
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0141 0.1401 1
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0662 0.0823
Schistosoma mansoni hypothetical protein 0.0184 0.1898 0.2365
Echinococcus granulosus GPCR family 2 0.0065 0.0513 0.061
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.069 1
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0192 0.199 0.2479
Echinococcus granulosus serine:threonine protein kinase PLK1 0.0096 0.0878 0.1068
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0055 0.0392 0.0486
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0205 0.2144 0.4069
Brugia malayi nuclear hormone receptor family member odr-7 0.0055 0.0392 0.0698
Schistosoma mansoni RAR-like nuclear receptor 0.0116 0.1102 0.1372
Echinococcus multilocularis TGF beta receptor type 1 0.0178 0.1828 0.1808

Activities

Activity type Activity value Assay description Source Reference
LC50 (functional) > 100 ug ml-1 Cytotoxicity against human K-562 cells after 5 days by MTT assay ChEMBL. 9917297

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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