Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0083 | 0.1207 | 0.3603 |
Toxoplasma gondii | hypothetical protein | 0.0055 | 0.0247 | 0.5 |
Schistosoma mansoni | acetyl-CoA C-acetyltransferase | 0.0052 | 0.0151 | 0.0448 |
Loa Loa (eye worm) | hypothetical protein | 0.0094 | 0.1586 | 0.4014 |
Schistosoma mansoni | bromodomain containing protein | 0.0146 | 0.3365 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0163 | 0.3953 | 1 |
Echinococcus granulosus | bromodomain adjacent to zinc finger domain | 0.0138 | 0.3083 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0339 | 1 | 1 |
Brugia malayi | Bromodomain containing protein | 0.0088 | 0.1394 | 0.2673 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0161 | 0.3875 | 0.3871 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0339 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0088 | 0.14 | 0.3541 |
Loa Loa (eye worm) | hypothetical protein | 0.0098 | 0.1737 | 0.4395 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0138 | 0.3083 | 1 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0339 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0161 | 0.3875 | 0.3871 |
Brugia malayi | Bromodomain containing protein | 0.0173 | 0.429 | 1 |
Mycobacterium ulcerans | hypothetical protein | 0.0179 | 0.4497 | 0.5 |
Echinococcus multilocularis | bromodomain adjacent to zinc finger domain | 0.0083 | 0.1207 | 0.3603 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0179 | 0.4497 | 0.5 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0058 | 0.0364 | 0.0358 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.