Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.533 | 0.9071 |
Brugia malayi | Pre-SET motif family protein | 0.0202 | 0.7826 | 1 |
Brugia malayi | RNA binding protein | 0.0142 | 0.533 | 0.6811 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.533 | 0.9071 |
Echinococcus multilocularis | musashi | 0.0026 | 0.0422 | 0.0791 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0422 | 0.0539 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0123 | 0.4532 | 1 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0029 | 0.054 | 0.3779 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0029 | 0.054 | 0.1013 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0991 | 0.1267 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0142 | 0.533 | 0.6811 |
Mycobacterium ulcerans | lipase LipD | 0.004 | 0.0991 | 1 |
Onchocerca volvulus | 0.004 | 0.0991 | 0.0664 | |
Mycobacterium tuberculosis | Possible conserved lipoprotein LpqK | 0.004 | 0.0991 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Plasmodium vivax | hypothetical protein, conserved | 0.004 | 0.0991 | 0.7141 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0026 | 0.0422 | 0.0539 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0123 | 0.4532 | 0.4515 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.147 | 0.1878 |
Echinococcus granulosus | lamin | 0.0026 | 0.0422 | 0.0791 |
Mycobacterium tuberculosis | Probable esterase LipL | 0.004 | 0.0991 | 0.0962 |
Plasmodium vivax | SET domain protein, putative | 0.0029 | 0.054 | 0.3779 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0017 | 0.0032 | 0.0041 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0111 | 0.4009 | 0.399 |
Brugia malayi | Pre-SET motif family protein | 0.0029 | 0.054 | 0.069 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0017 | 0.0032 | 0.0055 |
Mycobacterium tuberculosis | Probable reductase | 0.0111 | 0.4009 | 0.399 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0091 | 0.3158 | 0.4035 |
Loa Loa (eye worm) | beta-LACTamase domain containing family member | 0.004 | 0.0991 | 0.1267 |
Brugia malayi | Thioredoxin reductase | 0.0049 | 0.1375 | 0.1758 |
Plasmodium falciparum | glutathione reductase | 0.0049 | 0.1375 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0051 | 0.147 | 0.1878 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0051 | 0.147 | 0.1878 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0026 | 0.0422 | 0.0539 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0049 | 0.1375 | 0.2581 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.533 | 0.9071 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3158 | 0.5374 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0991 | 0.0962 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0991 | 0.7141 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.0202 | 0.7826 | 1 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.004 | 0.0991 | 0.7141 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0111 | 0.4009 | 0.399 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.533 | 0.9071 |
Brugia malayi | TAR-binding protein | 0.0142 | 0.533 | 0.6811 |
Echinococcus granulosus | lamin dm0 | 0.0026 | 0.0422 | 0.0791 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.054 | 0.0919 |
Echinococcus granulosus | tar DNA binding protein | 0.0142 | 0.533 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0142 | 0.533 | 0.6811 |
Schistosoma mansoni | lamin | 0.0026 | 0.0422 | 0.0718 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0991 | 0.107 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0051 | 0.147 | 0.1878 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0111 | 0.4009 | 0.399 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0991 | 0.107 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0991 | 0.1687 |
Mycobacterium ulcerans | esterase/lipase LipP | 0.004 | 0.0991 | 1 |
Mycobacterium ulcerans | fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE | 0.004 | 0.0991 | 1 |
Leishmania major | trypanothione reductase | 0.0049 | 0.1375 | 1 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.054 | 0.0919 |
Echinococcus multilocularis | beta LACTamase domain containing family member | 0.004 | 0.0991 | 0.186 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0123 | 0.4532 | 0.4515 |
Onchocerca volvulus | 0.004 | 0.0991 | 0.0664 | |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3158 | 0.5374 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0049 | 0.1375 | 1 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0142 | 0.533 | 0.6811 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0049 | 0.1375 | 0.1758 |
Toxoplasma gondii | ABC1 family protein | 0.004 | 0.0991 | 0.7141 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Echinococcus multilocularis | lamin dm0 | 0.0026 | 0.0422 | 0.0791 |
Toxoplasma gondii | thioredoxin reductase | 0.0049 | 0.1375 | 1 |
Schistosoma mansoni | intermediate filament proteins | 0.0026 | 0.0422 | 0.0718 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0029 | 0.054 | 0.0919 |
Loa Loa (eye worm) | TAR-binding protein | 0.0142 | 0.533 | 0.6811 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.3158 | 0.5925 |
Plasmodium falciparum | thioredoxin reductase | 0.0049 | 0.1375 | 1 |
Treponema pallidum | NADH oxidase | 0.0017 | 0.0032 | 0.5 |
Trypanosoma brucei | trypanothione reductase | 0.0049 | 0.1375 | 1 |
Brugia malayi | Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative | 0.004 | 0.0991 | 0.1267 |
Echinococcus granulosus | beta LACTamase domain containing family member | 0.004 | 0.0991 | 0.186 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0091 | 0.3158 | 0.5925 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0029 | 0.054 | 0.0919 |
Brugia malayi | beta-lactamase | 0.004 | 0.0991 | 0.1267 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0032 | 0.5 |
Wolbachia endosymbiont of Brugia malayi | dihydrolipoamide dehydrogenase E3 component | 0.0017 | 0.0032 | 0.5 |
Loa Loa (eye worm) | hypothetical protein | 0.0029 | 0.054 | 0.069 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0091 | 0.3158 | 0.5374 |
Brugia malayi | intermediate filament protein | 0.0026 | 0.0422 | 0.0539 |
Plasmodium vivax | glutathione reductase, putative | 0.0049 | 0.1375 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0229 | 0.9001 | 1 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0991 | 0.107 |
Loa Loa (eye worm) | intermediate filament protein | 0.0026 | 0.0422 | 0.0539 |
Mycobacterium ulcerans | beta-lactamase | 0.004 | 0.0991 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0142 | 0.533 | 0.9071 |
Loa Loa (eye worm) | hypothetical protein | 0.004 | 0.0991 | 0.1267 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0123 | 0.4532 | 0.4515 |
Onchocerca volvulus | 0.004 | 0.0991 | 0.0664 | |
Trypanosoma brucei | hypothetical protein, conserved | 0.004 | 0.0991 | 0.7141 |
Brugia malayi | beta-lactamase family protein | 0.004 | 0.0991 | 0.1267 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0029 | 0.054 | 0.1013 |
Schistosoma mansoni | family S12 unassigned peptidase (S12 family) | 0.004 | 0.0991 | 0.1687 |
Onchocerca volvulus | 0.0029 | 0.054 | 0.0137 | |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0035 | 0.0789 | 0.1009 |
Mycobacterium tuberculosis | Probable esterase/lipase LipP | 0.004 | 0.0991 | 0.0962 |
Loa Loa (eye worm) | hypothetical protein | 0.0035 | 0.0789 | 0.1009 |
Trichomonas vaginalis | D-aminoacylase, putative | 0.004 | 0.0991 | 0.107 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0049 | 0.1375 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0035 | 0.0789 | 0.1344 |
Echinococcus multilocularis | lamin | 0.0026 | 0.0422 | 0.0791 |
Mycobacterium tuberculosis | Probable conserved lipoprotein | 0.004 | 0.0991 | 0.0962 |
Onchocerca volvulus | 0.0229 | 0.9001 | 1 | |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0029 | 0.054 | 0.1013 |
Trichomonas vaginalis | esterase, putative | 0.004 | 0.0991 | 0.107 |
Trichomonas vaginalis | penicillin-binding protein, putative | 0.004 | 0.0991 | 0.107 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0991 | 0.0962 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0049 | 0.1375 | 0.2581 |
Loa Loa (eye worm) | glutathione reductase | 0.0049 | 0.1375 | 0.1758 |
Leishmania major | hypothetical protein, conserved | 0.004 | 0.0991 | 0.7141 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0111 | 0.4009 | 0.8522 |
Mycobacterium ulcerans | hypothetical protein | 0.004 | 0.0991 | 1 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0017 | 0.0032 | 0.006 |
Mycobacterium tuberculosis | Probable lipase LipD | 0.004 | 0.0991 | 0.0962 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0017 | 0.0032 | 0.5 |
Loa Loa (eye worm) | beta-lactamase | 0.004 | 0.0991 | 0.1267 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0017 | 0.0032 | 0.5 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0028 | 0.0495 | 0.0928 |
Echinococcus granulosus | intermediate filament protein | 0.0026 | 0.0422 | 0.0791 |
Mycobacterium tuberculosis | Conserved protein | 0.004 | 0.0991 | 0.0962 |
Echinococcus multilocularis | tar DNA binding protein | 0.0142 | 0.533 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0026 | 0.0402 | 0.0513 |
Mycobacterium tuberculosis | Probable lipase LipE | 0.004 | 0.0991 | 0.0962 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0111 | 0.4009 | 0.399 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.3158 | 0.5925 |
Brugia malayi | glutathione reductase | 0.0049 | 0.1375 | 0.1758 |
Mycobacterium tuberculosis | Probable hydrolase | 0.004 | 0.0991 | 0.0962 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0111 | 0.4009 | 0.399 |
Schistosoma mansoni | lamin | 0.0026 | 0.0422 | 0.0718 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0091 | 0.3158 | 0.4035 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0091 | 0.3158 | 0.5925 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0017 | 0.0032 | 0.006 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0049 | 0.1375 | 0.1348 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
Inhibition (binding) | = 2 % | Inhibition of wild type TTR aggregation expressed in Escherichia coli assessed as fibril formation at 7.2 uM after 72 hrs relative to untreated-control | ChEMBL. | 19191553 |
Inhibition (binding) | < 5 % | Inhibition of COX1 assessed as inhibition of arachidonic acid conversion to prostaglandin-E2 release at 10 uM | ChEMBL. | 19191553 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.