Species | Target name | Source | Bibliographic reference |
---|---|---|---|
Rattus norvegicus | Acetylcholinesterase | Starlite/ChEMBL | References |
Rattus norvegicus | Butyrylcholinesterase | Starlite/ChEMBL | References |
Species | Potential target | Known druggable target | Length | Alignment span | Identity |
---|---|---|---|---|---|
Echinococcus granulosus | BC026374 protein S09 family | Acetylcholinesterase | 614 aa | 642 aa | 34.1 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 632 aa | 25.6 % | |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 581 aa | 27.0 % | |
Echinococcus multilocularis | neuroligin | Acetylcholinesterase | 614 aa | 496 aa | 24.0 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 507 aa | 26.4 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 574 aa | 24.0 % |
Loa Loa (eye worm) | hypothetical protein | Acetylcholinesterase | 614 aa | 570 aa | 25.4 % |
Onchocerca volvulus | Acetylcholinesterase | 614 aa | 583 aa | 30.7 % | |
Onchocerca volvulus | Putative nuclear protein | Acetylcholinesterase | 614 aa | 577 aa | 40.7 % |
Brugia malayi | Carboxylesterase family protein | Butyrylcholinesterase | 597 aa | 537 aa | 31.7 % |
Onchocerca volvulus | Molybdopterin synthase catalytic subunit homolog | Acetylcholinesterase | 614 aa | 564 aa | 29.8 % |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | Acetylcholinesterase | 614 aa | 602 aa | 24.3 % |
Brugia malayi | Carboxylesterase family protein | Acetylcholinesterase | 614 aa | 573 aa | 30.5 % |
Echinococcus multilocularis | BC026374 protein (S09 family) | Acetylcholinesterase | 614 aa | 642 aa | 34.0 % |
Onchocerca volvulus | Carnitine O-palmitoyltransferase 2, mitochondrial homolog | Acetylcholinesterase | 614 aa | 531 aa | 39.7 % |
Drosophila melanogaster | CG10175 gene product from transcript CG10175-RE | Acetylcholinesterase | 614 aa | 547 aa | 32.5 % |
Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Brugia malayi | RNA binding protein | 0.0062 | 0.095 | 0.217 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0403 | 0.0403 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.095 | 0.095 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4379 | 0.4143 |
Echinococcus multilocularis | geminin | 0.0331 | 1 | 1 |
Loa Loa (eye worm) | RNA binding protein | 0.0062 | 0.095 | 0.217 |
Echinococcus multilocularis | tar DNA binding protein | 0.0062 | 0.095 | 0.057 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.095 | 0.095 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0062 | 0.095 | 0.217 |
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0062 | 0.095 | 0.217 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0045 | 0.0403 | 0.0921 |
Loa Loa (eye worm) | TAR-binding protein | 0.0062 | 0.095 | 0.217 |
Brugia malayi | TAR-binding protein | 0.0062 | 0.095 | 0.217 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0049 | 0.0519 | 0.1186 |
Loa Loa (eye worm) | hypothetical protein | 0.0049 | 0.0519 | 0.1186 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.095 | 0.095 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0403 | 0.0403 |
Echinococcus multilocularis | acetylcholinesterase | 0.0164 | 0.4379 | 0.4143 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 1 | 1 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0045 | 0.0403 | 0.0403 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4379 | 0.4143 |
Loa Loa (eye worm) | carboxylesterase | 0.0164 | 0.4379 | 1 |
Echinococcus granulosus | acetylcholinesterase | 0.0164 | 0.4379 | 0.4143 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4379 | 1 |
Loa Loa (eye worm) | acetylcholinesterase 1 | 0.0164 | 0.4379 | 1 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0045 | 0.0403 | 0.0921 |
Echinococcus granulosus | tar DNA binding protein | 0.0062 | 0.095 | 0.057 |
Echinococcus granulosus | carboxylesterase 5A | 0.0164 | 0.4379 | 0.4143 |
Echinococcus multilocularis | carboxylesterase 5A | 0.0164 | 0.4379 | 0.4143 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0049 | 0.0519 | 0.1186 |
Schistosoma mansoni | family S9 non-peptidase homologue (S09 family) | 0.0164 | 0.4379 | 0.4379 |
Schistosoma mansoni | hypothetical protein | 0.0331 | 1 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.095 | 0.095 |
Loa Loa (eye worm) | hypothetical protein | 0.0164 | 0.4379 | 1 |
Schistosoma mansoni | tar DNA-binding protein | 0.0062 | 0.095 | 0.095 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4379 | 1 |
Brugia malayi | Carboxylesterase family protein | 0.0164 | 0.4379 | 1 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0049 | 0.0519 | 0.1186 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.