TDR Targets

Basic information

Technical information

Name: Unnamed compound
MW: 399.44 | Formula: C21H25N3O5
H donors: 4 H acceptors: 4 LogP: -1.07 Rotable bonds: 13
Rule of 5 violations (Lipinski): 1
SMILES: N[C@H](C(=O)NCCCC(=O)O)CCC(=O)Nc1ccc(cc1)Oc1ccccc1
InChi: 1S/C21H25N3O5/c22-18(21(28)23-14-4-7-20(26)27)12-13-19(25)24-15-8-10-17(11-9-15)29-16-5-2-1-3-6-16/h1-3,5-6,8-11,18H,4,7,12-14,22H2,(H,23,28)(H,24,25)(H,26,27)/t18-/m0/s1
InChiKey: HNLFWLHYCOSXLD-SFHVURJKSA-N

Network

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Target Layer

Model Organisms

Species	Viewmode
Arabidopsis thaliana
Caenorhabditis elegans
Dictyostelium discoideum
Drosophila melanogaster
Escherichia coli
Homo sapiens
Mus musculus
Oryza sativa
Saccharomyces cerevisiae
Schmidtea mediterranea
Other organisms

TDR Pathogens:

Species	Viewmode
Brugia malayi
Chlamydia trachomatis
Echinococcus granulosus
Entamoeba histolytica
Echinococcus multilocularis
Giardia lamblia
Leishmania major
Loa Loa (eye worm)
Mycobacterium leprae
Mycobacterium tuberculosis
Mycobacterium ulcerans
Onchocerca volvulus
Plasmodium falciparum
Plasmodium vivax
Schistosoma mansoni
Trypanosoma brucei
Trypanosoma cruzi
Toxoplasma gondii
Treponema pallidum
Trichomonas vaginalis
Wolbachia endosymbiont of Brugia malayi

Other Pathogens:

Species	Viewmode
Babesia bovis
Candida albicans
Cryptosporidium hominis
Cryptosporidium parvum
Leishmania braziliensis
Leishmania donovani
Leishmania infantum
Leishmania mexicana
Neospora caninum
Plasmodium berghei
Plasmodium knowlesi
Plasmodium yoelii
Schistosoma japonicum
Trypanosoma brucei gambiense
Trypanosoma congolense
Theileria parva

Compound Layer

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Clustering layers

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species	Target name	Source	Bibliographic reference
Homo sapiens	leukotriene A4 hydrolase	Starlite/ChEMBL	References

Predicted pathogen targets for this compound

By orthology

Species	Potential target	Known druggable target/s	Ortholog Group
Loa Loa (eye worm)	leukotriene A4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Candida albicans	leukotriene A4 hydrolase/leucyl aminopeptidase	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus granulosus	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma japonicum	ko:K01254 leukotriene-A4 hydrolase [EC3.3.2.6], putative	Get druggable targets OG5_129538	All targets in OG5_129538
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	Get druggable targets OG5_129538	All targets in OG5_129538
Echinococcus multilocularis	leukotriene A 4 hydrolase	Get druggable targets OG5_129538	All targets in OG5_129538

By sequence similarity to non orthologous known druggable targets

Species	Potential target	Known druggable target	Length	Alignment span	Identity
Leishmania major	aminopeptidase-like protein,metallo-peptidase, Clan MA(E), Family M1	leukotriene A4 hydrolase	611 aa	508 aa	22.8 %

Ranking Plot

Putative Targets List

Species	Potential target	Raw	Global	Species
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0287	0.0514
Brugia malayi	ecdysteroid receptor	0.004	0.0287	0.0514
Echinococcus multilocularis	ecdysone induced protein 78C	0.004	0.0287	0.0287
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0022	0.004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Brugia malayi	hypothetical protein	0.0036	0.0246	0.044
Onchocerca volvulus		0.0033	0.0204	0.073
Echinococcus multilocularis	gcn5proteinral control of amino acid synthesis	0.0148	0.1533	0.1533
Brugia malayi	nuclear receptor NHR-67	0.0019	0.0046	0.0082
Schistosoma mansoni	hypothetical protein	0.0033	0.0212	0.0378
Schistosoma mansoni	nuclear receptor 2DBD-gamma	0.004	0.0287	0.0513
Loa Loa (eye worm)	nuclear hormone receptor-like 1	0.0021	0.0072	0.0128
Brugia malayi	Pre-SET motif family protein	0.0033	0.0204	0.0365
Trichomonas vaginalis	set domain proteins, putative	0.0259	0.2801	1
Brugia malayi	Bromodomain containing protein	0.0077	0.0717	0.1282
Echinococcus multilocularis	survival motor neuron protein 1	0.0233	0.2498	0.2498
Echinococcus multilocularis	fetal alzheimer antigen, falz	0.0022	0.0084	0.0084
Loa Loa (eye worm)	hypothetical protein	0.0038	0.0263	0.047
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0128
Schistosoma mansoni	RAR-like nuclear receptor	0.004	0.0287	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0502	0.5594	1
Echinococcus multilocularis	nuclear receptor subfamily 4 group A	0.0019	0.0046	0.0046
Echinococcus multilocularis	nuclear receptor subfamily 1 group D	0.0021	0.0072	0.0072
Echinococcus multilocularis	histone lysine methyltransferase setb histone lysine methyltransferase eggless	0.0049	0.0397	0.0397
Schistosoma mansoni	acetyl-CoA C-acetyltransferase	0.0022	0.0084	0.0151
Brugia malayi	isocitrate dehydrogenase	0.0031	0.0185	0.0331
Brugia malayi	calcium-independent alpha-latrotoxin receptor 2, putative	0.0015	0.0007	0.0012
Echinococcus multilocularis	isocitrate dehydrogenase	0.0031	0.0185	0.0185
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0185	0.5294
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0287	0.0287
Schistosoma mansoni	NADP-specific isocitrate dehydrogenase	0.0031	0.0185	0.0331
Trypanosoma cruzi	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0185	1
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0287	0.0513
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Plasmodium falciparum	isocitrate dehydrogenase [NADP], mitochondrial	0.0031	0.0185	0.6566
Schistosoma mansoni	hypothetical protein	0.0503	0.5599	1
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Loa Loa (eye worm)	RNA recognition domain-containing protein domain-containing protein	0.0062	0.0539	0.0964
Brugia malayi	TAR-binding protein	0.0062	0.0539	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Echinococcus multilocularis	FTZ F1 alpha	0.004	0.0287	0.0287
Brugia malayi	conserved hypotetical protein	0.0019	0.0046	0.0082
Echinococcus granulosus	hepatocyte nuclear factor 4 alpha	0.004	0.0287	0.0513
Echinococcus multilocularis	expressed protein	0.0017	0.0021	0.0021
Schistosoma mansoni	ferritin	0.0017	0.0021	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-40	0.004	0.0287	0.0514
Schistosoma mansoni	coup transcription factor	0.004	0.0287	0.0513
Echinococcus granulosus	methyl CpG binding domain protein 2	0.0017	0.0022	0.004
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0287	0.0513
Trichomonas vaginalis	bromodomain-containing protein, putative	0.0045	0.035	0.1249
Brugia malayi	Latrophilin receptor protein 2	0.0015	0.0007	0.0012
Loa Loa (eye worm)	hypothetical protein	0.007	0.0628	0.1123
Brugia malayi	Nuclear hormone receptor family member nhr-49	0.004	0.0287	0.0514
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-40	0.004	0.0287	0.0514
Echinococcus multilocularis	COUP TF:Svp nuclear hormone receptor	0.004	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0015	0.0007	0.0012
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0185	0.0185
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-1	0.004	0.0287	0.0514
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0045	0.035	0.0625
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0012
Schistosoma mansoni	retinoic acid receptor RXR	0.004	0.0287	0.0513
Schistosoma mansoni	ferritin	0.0017	0.0021	0.0037
Brugia malayi	ecdysone receptor	0.0019	0.0046	0.0082
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0185	0.0185
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Echinococcus multilocularis	zinc finger protein	0.0023	0.0092	0.0092
Brugia malayi	hypothetical protein	0.0128	0.1301	0.2326
Brugia malayi	Nuclear hormone receptor family member nhr-14	0.004	0.0287	0.0514
Trypanosoma brucei	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0185	1
Brugia malayi	RNA recognition motif domain containing protein	0.0062	0.0539	0.0964
Schistosoma mansoni	zinc finger protein	0.0023	0.0092	0.0164
Onchocerca volvulus		0.004	0.0287	0.1026
Brugia malayi	steroid hormone receptor	0.004	0.0287	0.0514
Schistosoma mansoni	hypothetical protein	0.0015	0.0003	0.0005
Entamoeba histolytica	acetyltransferase, GNAT family	0.0039	0.0282	1
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0046	0.0082
Schistosoma mansoni	zinc finger protein	0.0015	0.0003	0.0005
Echinococcus granulosus	nuclear receptor subfamily 1 group D	0.0021	0.0072	0.0128
Echinococcus multilocularis	geminin	0.0503	0.5599	0.5599
Echinococcus multilocularis	thyroid hormone receptor alpha	0.004	0.0287	0.0287
Brugia malayi	hypothetical protein	0.0019	0.0046	0.0082
Echinococcus granulosus	nuclear receptor subfamily 4 group A	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0182	0.1918	0.3429
Schistosoma mansoni	nuclear receptor	0.0019	0.0046	0.0082
Echinococcus multilocularis	Nuclear hormone receptor family member nhr 41	0.004	0.0287	0.0287
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-49	0.004	0.0287	0.0514
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0539	0.0963
Brugia malayi	Nuclear hormone receptor family member nhr-1	0.004	0.0287	0.0514
Trypanosoma brucei	ISWI complex protein	0.0015	0.0003	0.0143
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0128
Brugia malayi	N-terminal motif family protein	0.0182	0.1918	0.3429
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0019	0.0046	0.0163
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.0019	0.0046	0.0082
Mycobacterium ulcerans	bacterioferritin BfrB	0.0017	0.0021	1
Entamoeba histolytica	hypothetical protein	0.0036	0.0246	0.8731
Echinococcus granulosus	thyroid hormone receptor alpha	0.0019	0.0046	0.0082
Trypanosoma cruzi	isocitrate dehydrogenase, putative	0.0031	0.0185	1
Schistosoma mansoni	thyroid hormone receptor	0.004	0.0287	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0233	0.2498	0.4466
Giardia lamblia	Histone acetyltransferase GCN5	0.0039	0.0282	0.5
Loa Loa (eye worm)	nuclear receptor NHR-67	0.0019	0.0046	0.0082
Echinococcus multilocularis	NADP dependent isocitrate dehydrogenase	0.0031	0.0185	0.0185
Schistosoma mansoni	ferritin light chain	0.0017	0.0021	0.0037
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0287	0.0514
Schistosoma mansoni	ferritin	0.0017	0.0021	0.0037
Brugia malayi	Iron-sulfur cluster assembly accessory protein	0.0047	0.0374	0.0669
Echinococcus multilocularis	leukotriene A 4 hydrolase	0.0279	0.3029	0.3029
Onchocerca volvulus	Rap guanine nucleotide exchange factor 1 homolog	0.0182	0.1918	0.6849
Loa Loa (eye worm)	PHD-finger family protein	0.002	0.0063	0.0112
Entamoeba histolytica	hypothetical protein	0.0036	0.0246	0.8731
Brugia malayi	Calcitonin receptor-like protein seb-1	0.0049	0.0388	0.0694
Echinococcus multilocularis	methyl CpG binding domain protein 2	0.0017	0.0022	0.0022
Brugia malayi	Isocitrate dehydrogenase	0.0031	0.0185	0.0331
Schistosoma mansoni	nuclear hormone receptor nor-1/nor-2	0.004	0.0287	0.0513
Schistosoma mansoni	zinc finger protein	0.0019	0.0046	0.0082
Schistosoma mansoni	histone-lysine n-methyltransferase suv9	0.0033	0.0204	0.0365
Toxoplasma gondii	histone lysine acetyltransferase GCN5-A	0.0045	0.035	1
Brugia malayi	nuclear hormone receptor family member nhr-6	0.0019	0.0046	0.0082
Brugia malayi	PHD-finger family protein	0.0028	0.0152	0.0272
Loa Loa (eye worm)	leukotriene A4 hydrolase	0.0279	0.3029	0.5415
Echinococcus granulosus	Nuclear hormone receptor family member nhr 41	0.004	0.0287	0.0513
Trypanosoma brucei	isocitrate dehydrogenase, putative	0.0031	0.0185	1
Schistosoma mansoni	apoferritin-2	0.0017	0.0021	0.0037
Echinococcus granulosus	histone acetyltransferase KAT2B	0.0142	0.146	0.2607
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0397	0.0709
Brugia malayi	nuclear hormone receptor	0.0019	0.0046	0.0082
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0397	0.0709
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-31	0.004	0.0287	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Schistosoma mansoni	hypothetical protein	0.002	0.0063	0.0112
Schistosoma mansoni	bromodomain containing protein	0.0066	0.0585	0.1045
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Schistosoma mansoni	ferritin	0.0017	0.0021	0.0037
Brugia malayi	Corticotropin releasing factor receptor 2 precursor, putative	0.0049	0.0388	0.0694
Loa Loa (eye worm)	nuclear hormone receptor	0.0019	0.0046	0.0082
Schistosoma mansoni	photoreceptor-specific nuclear receptor related	0.004	0.0287	0.0513
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Brugia malayi	nuclear receptor NHR-88	0.004	0.0287	0.0514
Trichomonas vaginalis	cat eye syndrome critical region protein 2, cscr2, putative	0.0045	0.035	0.1249
Echinococcus multilocularis	tar DNA binding protein	0.0062	0.0539	0.0539
Echinococcus granulosus	geminin	0.0503	0.5599	1
Onchocerca volvulus	Nuclear receptor subfamily 6 group A member 1 homolog	0.0019	0.0046	0.0163
Schistosoma mansoni	nuclear hormone receptor	0.004	0.0287	0.0513
Schistosoma mansoni	hepatocyte nuclear factor 4-alpha (hnf-4-alpha)	0.0019	0.0046	0.0082
Echinococcus multilocularis	Basic leucine zipper (bZIP) transcription	0.0036	0.0246	0.0246
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0539	0.0963
Schistosoma mansoni	nuclear hormone receptor superfamily protein-related	0.0019	0.0046	0.0082
Brugia malayi	nuclear hormone receptor	0.004	0.0287	0.0514
Echinococcus granulosus	cadherin EGF LAG seven pass G type receptor	0.0015	0.0007	0.0012
Loa Loa (eye worm)	DR-78	0.0019	0.0046	0.0082
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0539	0.0963
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0035	0.0235	0.0235
Echinococcus multilocularis	FTZ F1 nuclear receptor protein	0.004	0.0287	0.0287
Schistosoma mansoni	Tr4/Tr2 (homologue)	0.004	0.0287	0.0513
Brugia malayi	orphan nuclear receptor NR2E1	0.0019	0.0046	0.0082
Loa Loa (eye worm)	bromodomain containing protein	0.0021	0.007	0.0126
Echinococcus granulosus	5'partial\|histone lysine N methyltransferase SETDB2	0.0031	0.0191	0.034
Echinococcus granulosus	Basic leucine zipper bZIP transcription	0.0036	0.0246	0.044
Echinococcus granulosus	FTZ F1 alpha	0.004	0.0287	0.0513
Mycobacterium ulcerans	bacterioferritin BfrA	0.0017	0.0021	1
Echinococcus granulosus	NADP dependent isocitrate dehydrogenase	0.0031	0.0185	0.0331
Brugia malayi	nuclear receptor subfamily 1, group D, member 1, putative	0.0019	0.0046	0.0082
Toxoplasma gondii	histone lysine acetyltransferase GCN5-B	0.0045	0.035	1
Plasmodium vivax	isocitrate dehydrogenase [NADP], mitochondrial, putative	0.0031	0.0185	0.5294
Brugia malayi	hypothetical protein	0.0019	0.0046	0.0082
Mycobacterium tuberculosis	Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP)	0.0031	0.0185	1
Echinococcus granulosus	ferritin	0.0017	0.0021	0.0037
Brugia malayi	tailless protein	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0128
Brugia malayi	nuclear receptor RXR	0.0021	0.0072	0.0128
Loa Loa (eye worm)	TAR-binding protein	0.0062	0.0539	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0128
Brugia malayi	acetyltransferase, GNAT family protein	0.0148	0.1533	0.2741
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0046	0.0082
Onchocerca volvulus	Protein ultraspiracle homolog	0.004	0.0287	0.1026
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0035	0.0235	0.0421
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0012
Schistosoma mansoni	nuclear hormone receptor	0.0019	0.0046	0.0082
Echinococcus granulosus	retinoic acid receptor rxr beta a	0.004	0.0287	0.0513
Echinococcus granulosus	histone lysine methyltransferase setb	0.0049	0.0397	0.0709
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Echinococcus granulosus	tar DNA binding protein	0.0062	0.0539	0.0963
Trichomonas vaginalis	ferritin, putative	0.0017	0.0021	0.0074
Echinococcus multilocularis	ferritin	0.0017	0.0021	0.0021
Toxoplasma gondii	isocitrate dehydrogenase	0.0031	0.0185	0.5294
Echinococcus granulosus	survival motor neuron protein 1	0.0233	0.2498	0.4462
Schistosoma mansoni	survival motor neuron protein	0.0047	0.0374	0.0668
Onchocerca volvulus	Bile acid receptor homolog	0.004	0.0287	0.1026
Echinococcus granulosus	nuclear receptor nhr 48	0.0019	0.0046	0.0082
Echinococcus granulosus	diuretic hormone 44 receptor GPRdih2	0.0015	0.0007	0.0012
Plasmodium vivax	SET domain protein, putative	0.0033	0.0204	0.5844
Echinococcus granulosus	FTZ F1 nuclear receptor protein	0.004	0.0287	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0021	0.0072	0.0128
Echinococcus multilocularis	bromodomain adjacent to zinc finger domain	0.0062	0.0545	0.0545
Echinococcus multilocularis	histone lysine N methyltransferase SETMAR	0.0033	0.0204	0.0204
Onchocerca volvulus		0.0259	0.2801	1
Brugia malayi	photoreceptor-specific nuclear receptor	0.0502	0.5594	1
Brugia malayi	Pre-SET motif family protein	0.0228	0.244	0.4362
Schistosoma mansoni	ecdysone-induced protein 78c (dr-78)	0.0021	0.0072	0.0128
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0003	0.0143
Onchocerca volvulus		0.0019	0.0046	0.0163
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0046	0.0352	0.063
Brugia malayi	Ligand-binding domain of nuclear hormone receptor family protein	0.004	0.0287	0.0514
Entamoeba histolytica	hypothetical protein	0.0036	0.0246	0.8731
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0046	0.0046
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0072	0.0128
Schistosoma mansoni	transcription factor LCR-F1	0.0036	0.0246	0.044
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Schistosoma mansoni	nuclear receptor nhr-48	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Brugia malayi	Nuclear hormone receptor family member nhr-19	0.004	0.0287	0.0514
Echinococcus multilocularis	retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha	0.0019	0.0046	0.0046
Plasmodium vivax	histone acetyltransferase GCN5, putative	0.0045	0.035	1
Schistosoma mansoni	steroid hormone receptor ad4bp	0.004	0.0287	0.0513
Echinococcus granulosus	ecdysone induced protein 78C	0.004	0.0287	0.0513
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0287	0.0514
Echinococcus multilocularis	diuretic hormone 44 receptor GPRdih2	0.0015	0.0007	0.0007
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0012
Brugia malayi	nuclear receptor NHR-88	0.0019	0.0046	0.0082
Loa Loa (eye worm)	hypothetical protein	0.0049	0.0388	0.0694
Brugia malayi	Steroid receptor seven-up type 2	0.004	0.0287	0.0514
Brugia malayi	Nuclear hormone receptor family member nhr-41	0.004	0.0287	0.0514
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Echinococcus multilocularis	GPCR, family 2	0.0015	0.0007	0.0007
Brugia malayi	nuclear hormone receptor family member odr-7	0.0019	0.0046	0.0082
Loa Loa (eye worm)	RNA binding protein	0.0062	0.0539	0.0964
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Echinococcus granulosus	bromodomain adjacent to zinc finger domain	0.0062	0.0545	0.0973
Leishmania major	isocitrate dehydrogenase [NADP], mitochondrial precursor, putative	0.0031	0.0185	1
Loa Loa (eye worm)	hypothetical protein	0.0033	0.0212	0.0378
Echinococcus granulosus	expressed protein	0.0017	0.0021	0.0037
Loa Loa (eye worm)	hypothetical protein	0.0044	0.0331	0.0591
Loa Loa (eye worm)	pigment dispersing factor receptor c	0.0049	0.0388	0.0694
Brugia malayi	Nuclear hormone receptor-like 1	0.0021	0.0072	0.0128
Schistosoma mansoni	hypothetical protein	0.0036	0.0246	0.044
Echinococcus granulosus	zinc finger protein	0.0023	0.0092	0.0164
Echinococcus granulosus	Nuclear hormone receptor HR96	0.0019	0.0046	0.0082
Loa Loa (eye worm)	pre-SET domain-containing protein family protein	0.0228	0.244	0.4362
Loa Loa (eye worm)	latrophilin receptor protein 2	0.0015	0.0007	0.0012
Echinococcus granulosus	COUP TF:Svp nuclear hormone receptor	0.004	0.0287	0.0513
Loa Loa (eye worm)	nuclear receptor nhr-7B	0.0019	0.0046	0.0082
Schistosoma mansoni	hypothetical protein	0.0503	0.5599	1
Schistosoma mansoni	hypothetical protein	0.0047	0.0374	0.0668
Loa Loa (eye worm)	hypothetical protein	0.004	0.0287	0.0514
Brugia malayi	hypothetical protein	0.0021	0.0072	0.0128
Echinococcus multilocularis	cadherin EGF LAG seven pass G type receptor	0.0015	0.0007	0.0007
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-14	0.004	0.0287	0.0514
Schistosoma mansoni	gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2	0.0148	0.1533	0.2739
Onchocerca volvulus	Steroid hormone receptor family member cnr14 homolog	0.004	0.0287	0.1026
Brugia malayi	Nuclear hormone receptor-like 1	0.004	0.0287	0.0514
Brugia malayi	hypothetical protein	0.0233	0.2498	0.4466
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.0021	0.0072	0.0128
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0539	0.0963
Loa Loa (eye worm)	nuclear Hormone Receptor family member	0.004	0.0287	0.0514
Echinococcus granulosus	GPCR family 2	0.0015	0.0007	0.0012
Schistosoma mansoni	hypothetical protein	0.0015	0.0007	0.0012
Brugia malayi	Nuclear hormone receptor E75	0.0019	0.0046	0.0082
Loa Loa (eye worm)	acetyltransferase	0.0148	0.1533	0.2741
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.0019	0.0046	0.0046
Toxoplasma gondii	histone lysine methyltransferase SET/SUV39	0.0033	0.0204	0.5844
Schistosoma mansoni	methyl-cpg binding protein mbd	0.0017	0.0022	0.004
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Brugia malayi	nuclear receptor RXR	0.0019	0.0046	0.0082
Trypanosoma cruzi	ISWI complex protein	0.0015	0.0003	0.0143
Schistosoma mansoni	leukotriene A4 hydrolase (M01 family)	0.0279	0.3029	0.541
Brugia malayi	Nuclear hormone receptor family member nhr-3	0.004	0.0287	0.0514
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0033	0.0204	0.0365
Brugia malayi	latrophilin 2 splice variant baaae	0.0033	0.0212	0.0378
Brugia malayi	hypothetical protein	0.0021	0.0072	0.0128
Echinococcus multilocularis	isocitrate dehydrogenase 2 (NADP+)	0.0031	0.0185	0.0185
Leishmania major	hypothetical protein, conserved	0.0015	0.0003	0.0143
Schistosoma mansoni	apoferritin-2	0.0017	0.0021	0.0037
Echinococcus granulosus	fetal alzheimer antigen falz	0.0022	0.0084	0.0151
Entamoeba histolytica	hypothetical protein	0.0036	0.0246	0.8731
Schistosoma mansoni	retinoid-x-receptor (RXR)	0.004	0.0287	0.0513
Brugia malayi	Nuclear hormone receptor family member nhr-31	0.004	0.0287	0.0514
Schistosoma mansoni	tar DNA-binding protein	0.0062	0.0539	0.0963
Echinococcus multilocularis	nuclear receptor nhr 48	0.0019	0.0046	0.0046
Brugia malayi	Bromodomain containing protein	0.0041	0.0303	0.0542
Schistosoma mansoni	nuclear receptor	0.0019	0.0046	0.0082
Echinococcus multilocularis	Nuclear hormone receptor HR96	0.0019	0.0046	0.0046
Wolbachia endosymbiont of Brugia malayi	bacterioferritin/cytochrome b1	0.0017	0.0021	0.5
Schistosoma mansoni	ferritin light chain	0.0017	0.0021	0.0037
Brugia malayi	RNA binding protein	0.0062	0.0539	0.0964
Echinococcus granulosus	leukotriene A 4 hydrolase	0.0279	0.3029	0.541
Loa Loa (eye worm)	nuclear hormone receptor family member nhr-41	0.004	0.0287	0.0514
Treponema pallidum	bacterioferrin (TpF1)	0.0017	0.0021	0.5
Schistosoma mansoni	FTZ-F1 nuclear receptor-like protein	0.004	0.0287	0.0513
Schistosoma mansoni	histone-lysine n-methyltransferase setb1	0.0049	0.0397	0.0709
Loa Loa (eye worm)	isocitrate dehydrogenase	0.0031	0.0185	0.0331
Onchocerca volvulus		0.0047	0.0374	0.1336
Loa Loa (eye worm)	steroid hormone receptor	0.004	0.0287	0.0514
Brugia malayi	Nuclear hormone receptor family member nhr-25	0.004	0.0287	0.0514
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Plasmodium falciparum	histone acetyltransferase GCN5	0.0039	0.0282	1
Onchocerca volvulus		0.0019	0.0046	0.0163
Echinococcus multilocularis	hepatocyte nuclear factor 4 alpha	0.004	0.0287	0.0287
Echinococcus multilocularis	nuclear receptor 2DBD gamma	0.004	0.0287	0.0287
Loa Loa (eye worm)	hypothetical protein	0.0019	0.0046	0.0082
Mycobacterium leprae	PROBABLE BACTERIOFERRITIN BFRA	0.0017	0.0021	0.5
Echinococcus granulosus	nuclear receptor 2DBD gamma	0.004	0.0287	0.0513

Activities

Activity type	Activity value	Assay description	Source	Reference
IC50 (binding)	= 19 nM	Inhibition of human recombinant LTA4-h by peptidase assay	ChEMBL.	18394906
IC50 (functional)	> 1000 nM	Inhibition of calcium ionophore-induced LTB4 synthesis in human whole blood after 15 mins by ELISA	ChEMBL.	18394906

Phenotypes

Whole-cell/tissue/organism interactions

Species name	Source	Reference	Is orphan
Homo sapiens	ChEMBL23	18394906

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?

In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.

In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

ChEMBL: CHEMBL514552

Bibliographic References

1 literature reference was collected for this gene.

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Detailed information for compound 1006729