Detailed information for compound 1007054

Basic information

Technical information
  • TDR Targets ID: 1007054
  • Name: 4-(2,7-dimethylimidazo[3,2-a]pyridin-3-yl)-N- (4-ethoxyphenyl)-1,3-thiazol-2-amine
  • MW: 364.464 | Formula: C20H20N4OS
  • H donors: 1 H acceptors: 2 LogP: 5.47 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 1
  • SMILES: CCOc1ccc(cc1)Nc1scc(n1)c1c(C)nc2n1ccc(c2)C
  • InChi: 1S/C20H20N4OS/c1-4-25-16-7-5-15(6-8-16)22-20-23-17(12-26-20)19-14(3)21-18-11-13(2)9-10-24(18)19/h5-12H,4H2,1-3H3,(H,22,23)
  • InChiKey: QHOAHHILQWLXIF-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 4-(2,7-dimethylimidazo[3,2-a]pyridin-3-yl)-N-(4-ethoxyphenyl)thiazol-2-amine
  • 4-(2,7-dimethyl-3-imidazo[3,2-a]pyridinyl)-N-(4-ethoxyphenyl)-2-thiazolamine
  • [4-(2,7-dimethylimidazo[3,2-a]pyridin-3-yl)thiazol-2-yl]-(4-ethoxyphenyl)amine
  • ST4054470
  • A2229/0093865
  • Oprea1_205980
  • CBMicro_038321

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.001 0.0047 0.0058
Onchocerca volvulus 0.0078 0.1436 0.2949
Mycobacterium tuberculosis Conserved protein 0.0078 0.1436 0.1286
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0058 0.0055
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0032 0.049 0.0608
Brugia malayi Nuclear hormone receptor family member nhr-31 0.001 0.0047 0.011
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0803 0.0981
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0133 0.2531 0.3125
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0012 0.0085 0.02
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0106 0.1985 0.1845
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0016 0.0171 0.0402
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0196
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0019 0.0225 0.0421
Schistosoma mansoni dishevelled 0.001 0.0058 0.0071
Schistosoma mansoni retinoic acid receptor RXR 0.001 0.0047 0.0058
Echinococcus granulosus FTZ F1 alpha 0.001 0.0047 0.0042
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0032 0.049 0.0592
Echinococcus granulosus zinc finger protein 0.0045 0.0749 0.0913
Echinococcus granulosus ecdysone induced protein 78C 0.001 0.0047 0.0042
Echinococcus granulosus beta LACTamase domain containing family member 0.0078 0.1436 0.1766
Brugia malayi Nuclear hormone receptor family member nhr-3 0.001 0.0047 0.011
Brugia malayi hypothetical protein 0.0026 0.0379 0.0891
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0012 0.0085 0.02
Schistosoma mansoni hypothetical protein 0.0166 0.3206 0.3973
Echinococcus multilocularis bromodomain adjacent to zinc finger domain 0.0079 0.1442 0.1774
Onchocerca volvulus 0.0248 0.4869 1
Echinococcus multilocularis muscleblind protein 1 0.015 0.288 0.3559
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.011
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0042
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0379 0.1647
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0078 0.1436 0.1286
Mycobacterium ulcerans hypothetical protein 0.0078 0.1436 1
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0803 0.0981
Schistosoma mansoni steroid hormone receptor ad4bp 0.001 0.0047 0.0058
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0058 0.0135
Treponema pallidum exodeoxyribonuclease (exoA) 0.0019 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0155 0.2988 0.698
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0079 0.1442 0.1774
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0042
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0803 0.0996
Loa Loa (eye worm) DIX domain-containing protein 0.001 0.0058 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1436 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.001 0.0048 0.0044
Onchocerca volvulus 0.0078 0.1436 0.2949
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0058 0.0055
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0604 0.0748
Trypanosoma cruzi ISWI complex protein 0.0034 0.0526 0.2805
Brugia malayi F/Y-rich N-terminus family protein 0.0014 0.0131 0.0307
Brugia malayi Pre-SET motif family protein 0.0032 0.049 0.1151
Plasmodium falciparum glutathione reductase 0.0046 0.0784 1
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.011
Schistosoma mansoni nuclear hormone receptor 0.001 0.0047 0.0058
Brugia malayi hypothetical protein 0.001 0.0058 0.0135
Toxoplasma gondii exonuclease III APE 0.0019 0.0225 0.1211
Brugia malayi Bromodomain containing protein 0.0084 0.1548 0.3633
Toxoplasma gondii LsmAD domain-containing protein 0.0026 0.0379 0.2336
Echinococcus multilocularis Pleckstrin G protein, interacting region 0.001 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.0095 0.1774 0.4098
Plasmodium vivax glutathione reductase, putative 0.0046 0.0784 0.4845
Echinococcus granulosus thioredoxin glutathione reductase 0.0046 0.0784 0.0957
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0042
Brugia malayi beta-lactamase family protein 0.0078 0.1436 0.337
Brugia malayi Thioredoxin reductase 0.0046 0.0784 0.184
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.1248 0.1546
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.001 0.0047 0.0042
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1436 0.2692
Brugia malayi Nuclear hormone receptor family member nhr-41 0.001 0.0047 0.011
Echinococcus multilocularis dnaJ subfamily B 0.0406 0.807 1
Leishmania major hypothetical protein, conserved 0.0078 0.1436 1
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0042
Echinococcus multilocularis muscleblind protein 0.015 0.288 0.3559
Trichomonas vaginalis esterase, putative 0.0078 0.1436 0.2692
Mycobacterium ulcerans beta-lactamase 0.0078 0.1436 1
Schistosoma mansoni cpg binding protein 0.0034 0.0542 0.0671
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.001 0.0047 0.0042
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0019 0.0225 0.0421
Onchocerca volvulus Protein ultraspiracle homolog 0.001 0.0047 0.0097
Brugia malayi photoreceptor-specific nuclear receptor 0.001 0.0047 0.011
Brugia malayi Nuclear hormone receptor family member nhr-49 0.001 0.0047 0.011
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0058 0.0055
Schistosoma mansoni cpg binding protein 0.0029 0.0424 0.0525
Echinococcus multilocularis thyroid hormone receptor alpha 0.001 0.0047 0.0042
Echinococcus granulosus bromodomain adjacent to zinc finger domain 0.0133 0.2531 0.3125
Loa Loa (eye worm) hypothetical protein 0.0089 0.1656 0.3819
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Trypanosoma cruzi ISWI complex protein 0.0034 0.0526 0.2805
Schistosoma mansoni hypothetical protein 0.0012 0.0085 0.0106
Brugia malayi Bromodomain containing protein 0.0166 0.3211 0.7536
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0008 0.0013 0.0016
Plasmodium falciparum thioredoxin reductase 0.0046 0.0784 1
Echinococcus granulosus muscleblind protein 0.015 0.288 0.3559
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0047 0.0803 0.0981
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1436 0.1779
Brugia malayi N-terminal motif family protein 0.0212 0.4138 0.9712
Schistosoma mansoni Tr4/Tr2 (homologue) 0.001 0.0047 0.0058
Brugia malayi Nuclear hormone receptor family member nhr-19 0.001 0.0047 0.011
Schistosoma mansoni coup transcription factor 0.001 0.0047 0.0058
Brugia malayi nuclear hormone receptor 0.001 0.0047 0.011
Mycobacterium tuberculosis Probable esterase LipL 0.0078 0.1436 0.1286
Echinococcus multilocularis fetal alzheimer antigen, falz 0.0051 0.0881 0.1077
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Onchocerca volvulus 0.001 0.0058 0.0118
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0078 0.1436 0.1286
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0016 0.0171 0.0825
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0058
Schistosoma mansoni zinc finger protein 0.0034 0.0526 0.0652
Schistosoma mansoni ap endonuclease 0.0019 0.0225 0.0278
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.001 0.0047 0.0042
Schistosoma mansoni bromodomain containing protein 0.0011 0.0069 0.0086
Onchocerca volvulus Rap guanine nucleotide exchange factor 1 homolog 0.0212 0.4138 0.8499
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0069 0.1248 0.1533
Loa Loa (eye worm) CXXC zinc finger family protein 0.0029 0.0424 0.0894
Onchocerca volvulus 0.0029 0.0424 0.087
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0025
Trypanosoma cruzi hypothetical protein, conserved 0.0078 0.1436 1
Leishmania major trypanothione reductase 0.0046 0.0784 0.4845
Schistosoma mansoni regulator of G protein signaling 0.001 0.0058 0.0071
Schistosoma mansoni hypothetical protein 0.0034 0.0526 0.0652
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0803 0.0996
Brugia malayi Nuclear hormone receptor family member nhr-25 0.001 0.0047 0.011
Plasmodium vivax thioredoxin reductase, putative 0.0046 0.0784 0.4845
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0047 0.0803 0.1886
Echinococcus multilocularis regulator of G protein signaling 7 0.001 0.0058 0.0055
Mycobacterium ulcerans esterase/lipase LipP 0.0078 0.1436 1
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0019 0.0225 1
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Schistosoma mansoni hypothetical protein 0.0045 0.0763 0.0945
Echinococcus multilocularis beta LACTamase domain containing family member 0.0078 0.1436 0.1766
Schistosoma mansoni dishevelled 0.001 0.0058 0.0071
Toxoplasma gondii NADPH-glutathione reductase 0.0016 0.0171 0.0825
Leishmania major hypothetical protein, conserved 0.0034 0.0526 0.2805
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Brugia malayi Pre-SET motif family protein 0.0218 0.426 1
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.001 0.0047 0.0097
Echinococcus granulosus Ataxin 2 N terminaldomain containing protein 0.0012 0.0085 0.009
Mycobacterium ulcerans lipase LipD 0.0078 0.1436 1
Schistosoma mansoni hypothetical protein 0.0166 0.3206 0.3973
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0196
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0016 0.0171 0.0212
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0078 0.1436 0.1286
Trypanosoma brucei PAB1-binding protein , putative 0.0026 0.0379 0.1647
Echinococcus multilocularis geminin 0.0166 0.3206 0.3963
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0117 0.2224 0.2088
Leishmania major hypothetical protein, conserved 0.0026 0.0379 0.1647
Schistosoma mansoni bromodomain containing protein 0.014 0.269 0.3334
Onchocerca volvulus Bile acid receptor homolog 0.001 0.0047 0.0097
Echinococcus granulosus Pleckstrin G protein interacting region 0.001 0.0058 0.0055
Plasmodium vivax SET domain protein, putative 0.0032 0.049 0.2523
Plasmodium vivax ataxin-2 like protein, putative 0.0026 0.0379 0.1647
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.001 0.0047 0.0058
Loa Loa (eye worm) glutathione reductase 0.0046 0.0784 0.1749
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0069 0.1248 0.1546
Echinococcus granulosus fetal alzheimer antigen falz 0.0051 0.0881 0.1077
Mycobacterium tuberculosis Probable oxidoreductase 0.0117 0.2224 0.2088
Loa Loa (eye worm) thioredoxin reductase 0.0046 0.0784 0.1749
Loa Loa (eye worm) bromodomain containing protein 0.0039 0.0631 0.1386
Echinococcus multilocularis zinc finger protein 0.0045 0.0749 0.0913
Brugia malayi steroid hormone receptor 0.001 0.0047 0.011
Brugia malayi beta-lactamase 0.0078 0.1436 0.337
Mycobacterium tuberculosis Conserved protein 0.0078 0.1436 0.1286
Brugia malayi Steroid receptor seven-up type 2 0.001 0.0047 0.011
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1436 0.2692
Trypanosoma brucei hypothetical protein, conserved 0.0078 0.1436 1
Brugia malayi regulator of G-protein signaling egl-10 0.001 0.0058 0.0135
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0106 0.1985 0.1845
Schistosoma mansoni zinc finger protein 0.0045 0.0749 0.0928
Mycobacterium tuberculosis Probable reductase 0.0106 0.1985 0.1845
Brugia malayi nuclear receptor NHR-88 0.001 0.0047 0.011
Brugia malayi hypothetical protein 0.001 0.0058 0.0135
Trypanosoma brucei trypanothione reductase 0.0046 0.0784 0.4845
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0225 0.0113
Loa Loa (eye worm) beta-lactamase 0.0078 0.1436 0.3296
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0019 0.0225 0.0262
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0019 0.0225 0.0262
Echinococcus granulosus dnaJ subfamily B 0.0406 0.807 1
Echinococcus granulosus methyl CpG binding domain protein 2 0.0037 0.0604 0.0733
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0062 0.1094 0.1356
Brugia malayi exodeoxyribonuclease III family protein 0.0019 0.0225 0.0527
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.001 0.0047 0.0058
Loa Loa (eye worm) hypothetical protein 0.0026 0.0379 0.0789
Schistosoma mansoni ap endonuclease 0.0019 0.0225 0.0278
Brugia malayi hypothetical protein 0.0017 0.0191 0.0447
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0019 0.0225 0.0421
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0106 0.1985 0.1845
Echinococcus multilocularis thioredoxin glutathione reductase 0.0046 0.0784 0.0957
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0019 0.0225 0.0421
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0019 0.0225 0.0054
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0117 0.2224 0.2088
Echinococcus granulosus segment polarity protein dishevelled 0.001 0.0058 0.0055
Echinococcus granulosus regulator of G protein signaling 7 0.001 0.0058 0.0055
Onchocerca volvulus 0.001 0.0047 0.0097
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1436 0.2692
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0078 0.1436 0.1779
Trypanosoma brucei ISWI complex protein 0.0034 0.0526 0.2805
Trichomonas vaginalis ap endonuclease, putative 0.0019 0.0225 0.0113
Trypanosoma cruzi trypanothione reductase, putative 0.0046 0.0784 0.4845
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0025
Echinococcus multilocularis ecdysone induced protein 78C 0.001 0.0047 0.0042
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0058 0.0055
Loa Loa (eye worm) hypothetical protein 0.015 0.288 0.6725
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0016 0.0171 0.5
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0047 0.0803 0.0981
Toxoplasma gondii thioredoxin reductase 0.0046 0.0784 0.527
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0106 0.1985 0.6971
Schistosoma mansoni methyl-cpg binding protein mbd 0.0037 0.0604 0.0748
Loa Loa (eye worm) hypothetical protein 0.015 0.288 0.6725
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.001 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.0011 0.0069 0.0053
Schistosoma mansoni hypothetical protein 0.0406 0.807 1
Schistosoma mansoni z-protein (S1r protein) 0.001 0.0058 0.0071
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0046 0.0784 0.0623
Brugia malayi Nuclear hormone receptor family member nhr-1 0.001 0.0047 0.011
Schistosoma mansoni cpg binding protein 0.0034 0.0542 0.0671
Schistosoma mansoni dep domain containing protein 0.001 0.0058 0.0071
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0225 0.0869
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0047 0.0803 0.1795
Echinococcus multilocularis methyl CpG binding domain protein 2 0.0037 0.0604 0.0733
Schistosoma mansoni retinoid-x-receptor (RXR) 0.001 0.0047 0.0058
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0032 0.049 0.0608
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0078 0.1436 1
Schistosoma mansoni RAR-like nuclear receptor 0.001 0.0047 0.0058
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0379 0.3398
Brugia malayi DIX domain containing protein 0.001 0.0058 0.0135
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0218 0.426 1
Brugia malayi Muscleblind-like protein 0.015 0.288 0.6761
Schistosoma mansoni fyve finger-containing phosphoinositide kinase fyv1 0.001 0.0058 0.0071
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0078 0.1436 0.3296
Brugia malayi Nuclear hormone receptor-like 1 0.001 0.0047 0.011
Echinococcus granulosus histone lysine methyltransferase setb 0.0069 0.1248 0.1533
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.011
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0019 0.0225 0.0421
Schistosoma mansoni acetyl-CoA C-acetyltransferase 0.0051 0.0881 0.1091
Echinococcus granulosus geminin 0.0166 0.3206 0.3963
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0019 0.0225 0.0421
Echinococcus granulosus cpg binding protein 0.0034 0.0542 0.0656
Onchocerca volvulus 0.0032 0.049 0.1007
Onchocerca volvulus Segment polarity protein dishevelled homolog 0.001 0.0058 0.0118
Loa Loa (eye worm) hypothetical protein 0.0078 0.1436 0.3296
Brugia malayi glutathione reductase 0.0046 0.0784 0.184
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.001 0.0047 0.0042
Brugia malayi Nuclear hormone receptor family member nhr-14 0.001 0.0047 0.011
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.001 0.0047 0.011
Toxoplasma gondii ABC1 family protein 0.0078 0.1436 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0117 0.2224 1
Brugia malayi Nuclear hormone receptor family member nhr-40 0.001 0.0047 0.011
Trypanosoma cruzi PAB1-binding protein , putative 0.0026 0.0379 0.1647
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0019 0.0225 0.0421
Loa Loa (eye worm) hypothetical protein 0.0212 0.4138 0.9708
Onchocerca volvulus 0.0078 0.1436 0.2949
Trichomonas vaginalis penicillin-binding protein, putative 0.0078 0.1436 0.2692
Echinococcus multilocularis segment polarity protein dishevelled 0.001 0.0058 0.0055
Brugia malayi CXXC zinc finger family protein 0.0029 0.0424 0.0995
Mycobacterium tuberculosis Probable lipase LipD 0.0078 0.1436 0.1286
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.001 0.0047 0.0058
Trichomonas vaginalis set domain proteins, putative 0.0248 0.4869 1
Brugia malayi Domain found in Dishevelled, Egl-10, and Pleckstrin family protein 0.001 0.0058 0.0135
Loa Loa (eye worm) hypothetical protein 0.0069 0.1248 0.285
Echinococcus multilocularis FTZ F1 alpha 0.001 0.0047 0.0042
Echinococcus granulosus nuclear receptor 2DBD gamma 0.001 0.0047 0.0042
Brugia malayi PHD-finger family protein 0.0056 0.0986 0.2314
Trichomonas vaginalis D-aminoacylase, putative 0.0078 0.1436 0.2692
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0078 0.1436 0.337
Mycobacterium tuberculosis Probable hydrolase 0.0078 0.1436 0.1286
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.001 0.0048 0.0044
Echinococcus granulosus retinoic acid receptor rxr beta a 0.001 0.0047 0.0042
Loa Loa (eye worm) hypothetical protein 0.001 0.0058 0.0025
Plasmodium vivax hypothetical protein, conserved 0.0078 0.1436 1
Mycobacterium tuberculosis Probable dehydrogenase 0.0106 0.1985 0.1845
Loa Loa (eye worm) PHD-finger family protein 0.0045 0.0763 0.1699
Mycobacterium tuberculosis Probable lipase LipE 0.0078 0.1436 0.1286
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0019 0.0225 0.5
Plasmodium falciparum ataxin-2 like protein, putative 0.0026 0.0379 0.3398
Loa Loa (eye worm) histone methyltransferase 0.001 0.0048 0.0003
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.001 0.0047 0.0042
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0032 0.049 0.314
Brugia malayi beta-lactamase family protein 0.0078 0.1436 0.337
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0019 0.0225 1
Loa Loa (eye worm) G protein signaling regulator EGL-10 0.001 0.0058 0.0025
Echinococcus multilocularis Ataxin 2, N terminal,domain containing protein 0.0012 0.0085 0.009
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.003 0.0454 0.0548
Mycobacterium tuberculosis Conserved protein 0.0078 0.1436 0.1286
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0047 0.0803 0.0996
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.1069 0.7337
Brugia malayi ecdysteroid receptor 0.001 0.0047 0.011
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0106 0.1985 0.1845
Echinococcus multilocularis cpg binding protein 0.0034 0.0542 0.0656
Loa Loa (eye worm) hypothetical protein 0.0084 0.1551 0.3569
Schistosoma mansoni thyroid hormone receptor 0.001 0.0047 0.0058

Activities

No activities found for this compound.

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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