Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Plasmodium falciparum | thioredoxin reductase | 0.0037 | 0.037 | 0.1828 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1757 | 0.3592 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.1357 | 0.6071 |
Plasmodium vivax | glutathione reductase, putative | 0.0037 | 0.037 | 0.1828 |
Brugia malayi | Corticotropin releasing factor receptor 2 precursor, putative | 0.0258 | 0.7188 | 1 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.2236 | 1 |
Echinococcus granulosus | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.1757 | 0.1655 |
Toxoplasma gondii | thioredoxin reductase | 0.0037 | 0.037 | 1 |
Plasmodium vivax | hypothetical protein, conserved | 0.003 | 0.0156 | 0.0252 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.2236 | 1 |
Mycobacterium tuberculosis | Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0122 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1479 | 0.1921 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1479 | 0.1921 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.2236 | 1 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0037 | 0.0385 | 0.0266 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.2236 | 1 |
Trypanosoma brucei | trypanothione reductase | 0.0037 | 0.037 | 1 |
Giardia lamblia | PHD finger protein 15 | 0.003 | 0.0156 | 0.5 |
Mycobacterium ulcerans | long-chain fatty-acid CoA ligase | 0.0097 | 0.2236 | 1 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0037 | 0.037 | 0.1828 |
Echinococcus granulosus | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.1757 | 0.1655 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2236 | 0.2991 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0083 | 0.1814 | 0.8112 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0156 | 0.1378 |
Mycobacterium tuberculosis | Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) | 0.0028 | 0.0122 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0808 | 0.0971 |
Mycobacterium tuberculosis | Probable peptide synthetase Nrp (peptide synthase) | 0.0028 | 0.0122 | 0.0546 |
Loa Loa (eye worm) | latrophilin receptor protein 2 | 0.0082 | 0.1757 | 0.2314 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0122 | 0.0546 |
Loa Loa (eye worm) | transcription factor SMAD2 | 0.0121 | 0.2981 | 0.4046 |
Mycobacterium tuberculosis | Peptide synthetase MbtF (peptide synthase) | 0.0028 | 0.0122 | 0.0546 |
Mycobacterium leprae | PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) | 0.0097 | 0.2236 | 1 |
Brugia malayi | jmjC domain containing protein | 0.0097 | 0.2233 | 0.2987 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0083 | 0.1814 | 0.8112 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.2236 | 1 |
Schistosoma mansoni | hypothetical protein | 0.003 | 0.0156 | 0.0075 |
Mycobacterium tuberculosis | Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) | 0.0097 | 0.2236 | 1 |
Mycobacterium tuberculosis | Probable reductase | 0.0083 | 0.1814 | 0.8112 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.003 | 0.0156 | 0.1378 |
Brugia malayi | Bromodomain containing protein | 0.003 | 0.0156 | 0.0048 |
Schistosoma mansoni | hypothetical protein | 0.0176 | 0.4674 | 1 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0028 | 0.0122 | 0.5 |
Brugia malayi | Thioredoxin reductase | 0.0037 | 0.037 | 0.0351 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.2236 | 0.2991 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0036 | 0.0348 | 0.0229 |
Mycobacterium tuberculosis | Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) | 0.0028 | 0.0122 | 0.0546 |
Onchocerca volvulus | 0.0051 | 0.0818 | 0.3292 | |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.0093 | 0.21 | 0.936 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0083 | 0.1814 | 0.8112 |
Mycobacterium tuberculosis | Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase | 0.0028 | 0.0122 | 0.0546 |
Loa Loa (eye worm) | hypothetical protein | 0.0051 | 0.0818 | 0.0985 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0037 | 0.037 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1757 | 0.3592 |
Brugia malayi | MH2 domain containing protein | 0.0121 | 0.2981 | 0.4046 |
Brugia malayi | Latrophilin receptor protein 2 | 0.0082 | 0.1757 | 0.2314 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.2236 | 0.2991 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0122 | 0.0546 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.0093 | 0.21 | 0.9395 |
Onchocerca volvulus | 0.0097 | 0.2236 | 1 | |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.1357 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1479 | 0.1921 |
Brugia malayi | PHD-finger family protein | 0.003 | 0.0156 | 0.0048 |
Echinococcus multilocularis | tumor protein p63 | 0.0349 | 1 | 1 |
Brugia malayi | glutathione reductase | 0.0037 | 0.037 | 0.0351 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.003 | 0.0156 | 0.0035 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0037 | 0.037 | 0.0351 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0037 | 0.0385 | 0.0266 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0348 | 0.0497 |
Schistosoma mansoni | cellular tumor antigen P53 | 0.0051 | 0.0818 | 0.1529 |
Leishmania major | trypanothione reductase | 0.0037 | 0.037 | 0.1174 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0037 | 0.037 | 0.1656 |
Echinococcus multilocularis | peregrin | 0.003 | 0.0156 | 0.0035 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0083 | 0.1814 | 0.8112 |
Leishmania major | 4-coumarate:coa ligase-like protein | 0.0097 | 0.2236 | 1 |
Loa Loa (eye worm) | pigment dispersing factor receptor c | 0.0258 | 0.7188 | 1 |
Mycobacterium leprae | PROBABLE NADH DEHYDROGENASE NDH | 0.0083 | 0.1814 | 0.8003 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0097 | 0.2236 | 1 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0083 | 0.1814 | 0.8112 |
Echinococcus granulosus | Mitotic checkpoint protein PRCC C terminal | 0.0122 | 0.2993 | 0.2906 |
Schistosoma mansoni | hypothetical protein | 0.0122 | 0.2993 | 0.6307 |
Plasmodium falciparum | phd finger protein, putative | 0.003 | 0.0156 | 0.0252 |
Echinococcus granulosus | peregrin | 0.003 | 0.0156 | 0.0035 |
Brugia malayi | calcium-independent alpha-latrotoxin receptor 2, putative | 0.0082 | 0.1757 | 0.2314 |
Loa Loa (eye worm) | hypothetical protein | 0.003 | 0.0156 | 0.0048 |
Loa Loa (eye worm) | MH2 domain-containing protein | 0.0121 | 0.2981 | 0.4046 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.1357 | 0.6071 |
Brugia malayi | AMP-binding enzyme family protein | 0.0097 | 0.2236 | 0.2991 |
Echinococcus granulosus | GPCR family 2 | 0.0082 | 0.1757 | 0.1655 |
Echinococcus multilocularis | thyroid hormone receptor alpha | 0.0131 | 0.3294 | 0.3211 |
Loa Loa (eye worm) | hypothetical protein | 0.0258 | 0.7188 | 1 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0061 | 0.1128 | 0.1424 |
Mycobacterium ulcerans | acyl-CoA synthetase | 0.0097 | 0.2236 | 1 |
Schistosoma mansoni | jumonji domain containing protein | 0.0077 | 0.1619 | 0.3287 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.0093 | 0.21 | 0.9395 |
Mycobacterium tuberculosis | Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0069 | 0.1357 | 0.6071 |
Loa Loa (eye worm) | hypothetical protein | 0.0082 | 0.1757 | 0.2314 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2236 | 0.2991 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1757 | 0.3592 |
Onchocerca volvulus | Alhambra homolog | 0.003 | 0.0156 | 0.0162 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.2236 | 1 |
Mycobacterium tuberculosis | Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) | 0.0073 | 0.1479 | 0.6617 |
Entamoeba histolytica | acyl-CoA synthetase, putative | 0.0097 | 0.2236 | 1 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0097 | 0.2236 | 1 |
Echinococcus multilocularis | cadherin EGF LAG seven pass G type receptor | 0.0082 | 0.1757 | 0.1655 |
Echinococcus multilocularis | Mitotic checkpoint protein PRCC, C terminal | 0.0122 | 0.2993 | 0.2906 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1479 | 0.1921 |
Trichomonas vaginalis | antibiotic synthetase, putative | 0.0028 | 0.0122 | 0.5 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0097 | 0.2233 | 0.2137 |
Echinococcus granulosus | jumonji domain containing protein | 0.0041 | 0.0514 | 0.0397 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.0093 | 0.21 | 0.9395 |
Mycobacterium tuberculosis | Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) | 0.0028 | 0.0122 | 0.0546 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.003 | 0.0156 | 0.0075 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0097 | 0.2233 | 0.2137 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0036 | 0.0348 | 0.0497 |
Loa Loa (eye worm) | glutathione reductase | 0.0037 | 0.037 | 0.0351 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0036 | 0.0348 | 0.032 |
Plasmodium falciparum | acyl-CoA synthetase | 0.0073 | 0.1479 | 1 |
Brugia malayi | Calcitonin receptor-like protein seb-1 | 0.0258 | 0.7188 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0176 | 0.4674 | 0.6443 |
Brugia malayi | latrophilin 2 splice variant baaae | 0.0176 | 0.4674 | 0.6443 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.3294 | 0.6968 |
Plasmodium vivax | acyl-CoA synthetase, putative | 0.0073 | 0.1479 | 1 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0041 | 0.0514 | 0.0397 |
Schistosoma mansoni | thyroid hormone receptor | 0.0131 | 0.3294 | 0.6968 |
Echinococcus multilocularis | GPCR, family 2 | 0.0082 | 0.1757 | 0.1655 |
Plasmodium falciparum | glutathione reductase | 0.0037 | 0.037 | 0.1828 |
Loa Loa (eye worm) | hypothetical protein | 0.0073 | 0.1479 | 0.1921 |
Chlamydia trachomatis | acylglycerophosphoethanolamine acyltransferase | 0.0073 | 0.1479 | 0.5 |
Mycobacterium tuberculosis | Peptide synthetase MbtE (peptide synthase) | 0.0028 | 0.0122 | 0.0546 |
Echinococcus multilocularis | diuretic hormone 44 receptor GPRdih2 | 0.0082 | 0.1757 | 0.1655 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0036 | 0.0348 | 0.0229 |
Mycobacterium ulcerans | long-chain-fatty-acid-CoA ligase | 0.0097 | 0.2236 | 1 |
Loa Loa (eye worm) | PHD-finger family protein | 0.003 | 0.0156 | 0.0048 |
Mycobacterium ulcerans | hypothetical protein | 0.0097 | 0.2236 | 1 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.003 | 0.0156 | 0.0035 |
Entamoeba histolytica | acyl-coA synthetase, putative | 0.0097 | 0.2236 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0097 | 0.2236 | 0.2991 |
Mycobacterium tuberculosis | P-hydroxybenzoyl-AMP ligase FadD22 | 0.0028 | 0.0122 | 0.0546 |
Mycobacterium ulcerans | long-chain-fatty-acid--CoA ligase | 0.0097 | 0.2236 | 1 |
Schistosoma mansoni | hypothetical protein | 0.0082 | 0.1757 | 0.3592 |
Brugia malayi | jmjC domain containing protein | 0.0036 | 0.0348 | 0.032 |
Mycobacterium ulcerans | fatty-acid-CoA ligase | 0.0073 | 0.1479 | 0.6421 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.