Detailed information for compound 1007645

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 613.865 | Formula: C23H22BrClN4O7S
  • H donors: 4 H acceptors: 7 LogP: 7.01 Rotable bonds: 5
    Rule of 5 violations (Lipinski): 2
  • SMILES: [O-][Cl](=O)(=O)=O.Cc1cc(C)[n+](c(c1)C)NC(=O)c1[nH]c2c(c1c1ccc(cc1)Br)cc(cc2)S(=O)(=O)N
  • InChi: 1S/C23H21BrN4O3S.ClHO4/c1-13-10-14(2)28(15(3)11-13)27-23(29)22-21(16-4-6-17(24)7-5-16)19-12-18(32(25,30)31)8-9-20(19)26-22;2-1(3,4)5/h4-12H,1-3H3,(H3-,25,26,27,29,30,31);(H,2,3,4,5)
  • InChiKey: CZMRPZLKKAXUCV-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens carbonic anhydrase I Starlite/ChEMBL References
Candida albicans Involved in protection against oxidative damage Starlite/ChEMBL References
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) References
Homo sapiens carbonic anhydrase II Starlite/ChEMBL References
Mycobacterium tuberculosis Beta-carbonic anhydrase References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_135410 All targets in OG5_135410
Leishmania braziliensis carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127503 All targets in OG5_127503
Plasmodium berghei inorganic anion antiporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania major carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Plasmodium vivax sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium tuberculosis Beta-carbonic anhydrase Get druggable targets OG5_135410 All targets in OG5_135410
Leishmania mexicana carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei gambiense hypothetical protein, conserved Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB Get druggable targets OG5_127503 All targets in OG5_127503
Theileria parva sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Loa Loa (eye worm) carbonic anhydrase 3 Get druggable targets OG5_127628 All targets in OG5_127628
Plasmodium yoelii sulfate permease family protein Get druggable targets OG5_129533 All targets in OG5_129533
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Schistosoma japonicum ko:K01672 carbonic anhydrase [EC4.2.1.1], putative Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania braziliensis carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Neospora caninum hypothetical protein Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania infantum carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Babesia bovis sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
Plasmodium knowlesi sulfate transporter, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania major carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei gambiense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Brugia malayi Eukaryotic-type carbonic anhydrase family protein Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus granulosus carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense hypothetical protein, conserved Get druggable targets OG5_129533 All targets in OG5_129533
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter Get druggable targets OG5_129533 All targets in OG5_129533
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase Get druggable targets OG5_127628 All targets in OG5_127628
Trypanosoma congolense carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Schistosoma mansoni carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium leprae Probable transmembrane transport protein Get druggable targets OG5_129533 All targets in OG5_129533
Candida albicans hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Leishmania mexicana carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Entamoeba histolytica carbonic anhydrase, putative Get druggable targets OG5_127503 All targets in OG5_127503
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) Get druggable targets OG5_129533 All targets in OG5_129533
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium tuberculosis Probable conserved transmembrane protein Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Brugia malayi Putative carbonic anhydrase 5 precursor Get druggable targets OG5_127628 All targets in OG5_127628
Leishmania donovani carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) Get druggable targets OG5_127628 All targets in OG5_127628
Echinococcus multilocularis carbonic anhydrase II Get druggable targets OG5_127628 All targets in OG5_127628
Candida albicans Involved in protection against oxidative damage Get druggable targets OG5_127503 All targets in OG5_127503
Trichomonas vaginalis conserved hypothetical protein Get druggable targets OG5_135410 All targets in OG5_135410
Trypanosoma congolense Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma brucei carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans integral membrane transporter Get druggable targets OG5_129533 All targets in OG5_129533
Chlamydia trachomatis sulfate transporter Get druggable targets OG5_129533 All targets in OG5_129533
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein Get druggable targets OG5_129533 All targets in OG5_129533
Mycobacterium ulcerans carbonic anhydrase Get druggable targets OG5_127503 All targets in OG5_127503
Leishmania donovani carbonic anhydrase family protein, putative Get druggable targets OG5_127503 All targets in OG5_127503
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative Get druggable targets OG5_129533 All targets in OG5_129533
Leishmania infantum carbonic anhydrase-like protein Get druggable targets OG5_127628 All targets in OG5_127628
Mycobacterium ulcerans transmembrane carbonic anhydrase, SulP Get druggable targets OG5_129533 All targets in OG5_129533
Trypanosoma cruzi carbonic anhydrase-like protein, putative Get druggable targets OG5_127628 All targets in OG5_127628
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei carbonic anhydrase-like protein carbonic anhydrase I 261 aa 281 aa 25.3 %
Brugia malayi Carbonic anhydrase like protein 2 precursor carbonic anhydrase II 260 aa 259 aa 32.0 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.003 0.0014 0.0001
Brugia malayi nuclear hormone receptor family member odr-7 0.0051 0.0159 0.0146
Loa Loa (eye worm) hypothetical protein 0.0152 0.0838 0.0827
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.1513 1 1
Schistosoma mansoni patched 1 0.0042 0.0095 0.0083
Mycobacterium ulcerans carbonic anhydrase 0.1353 0.8926 0.8918
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0112 0.0569 0.0557
Schistosoma mansoni gabp alpha 0.0079 0.0342 0.033
Brugia malayi hypothetical protein 0.0057 0.02 0.0188
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 20 0.0038 0.0069 0.0057
Echinococcus granulosus ubiquitin specific peptidase 30 (C19 family) 0.0038 0.0069 0.0064
Toxoplasma gondii hypothetical protein 0.0048 0.0134 0.0121
Plasmodium falciparum ubiquitin specific protease, putative 0.0038 0.0069 0.0055
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0059 0.0211 0.0198
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) fli-1 protein 0.0238 0.1418 0.1408
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0546 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis ferritin, putative 0.0134 0.0718 0.0804
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.034 0.2103 0.2093
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0059 0.0211 0.0198
Trichomonas vaginalis conserved hypothetical protein 0.0039 0.0077 0.0086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0587 0.3765 0.4702
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Treponema pallidum bacterioferrin (TpF1) 0.0134 0.0718 0.0317
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.1353 0.8926 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0069 0.1378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 16 0.0038 0.0069 0.0057
Brugia malayi Ets-domain containing protein 0.0079 0.0342 0.033
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Echinococcus granulosus Niemann Pick C1 protein 0.0098 0.047 0.0465
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Echinococcus granulosus Ubiquitin carboxyl terminal hydrolase 48 0.0038 0.0069 0.0064
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0109 0.0546 0.0534
Mycobacterium leprae Probable transmembrane transport protein 0.0285 0.1732 0.1233
Echinococcus granulosus Smad4 0.0059 0.0211 0.0205
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0089 0.0414 0.0338
Schistosoma mansoni nuclear hormone receptor 0.0109 0.0546 0.0534
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 5 0.0038 0.0069 0.0064
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0265 0.0253
Plasmodium vivax sulfate transporter, putative 0.0039 0.0078 0.0065
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0047 0.0129 0.0116
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0109 0.0546 0.0534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Schistosoma mansoni hypothetical protein 0.004 0.0085 0.0073
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Schistosoma mansoni ubiquitin-specific peptidase 42 (C19 family) 0.0038 0.0069 0.0057
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0089 0.0414 0.0402
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0051 0.0159 0.0154
Brugia malayi orphan nuclear receptor NR2E1 0.0051 0.0159 0.0146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0587 0.3765 0.4702
Loa Loa (eye worm) beta-lactamase 0.0112 0.0569 0.0557
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis expressed conserved protein 0.0092 0.0431 0.0418
Brugia malayi Ets-domain containing protein 0.0079 0.0342 0.033
Brugia malayi conserved hypotetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni carbonic anhydrase 0.0067 0.0265 0.0253
Mycobacterium tuberculosis Probable oxidoreductase 0.0652 0.4206 0.5292
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis rotamase, putative 0.0039 0.0077 0.0086
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni intermediate filament proteins 0.0228 0.1349 0.1339
Trypanosoma cruzi trypanothione reductase, putative 0.0089 0.0414 0.2014
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Loa Loa (eye worm) isocitrate dehydrogenase 0.0065 0.0252 0.024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0098 0.047 0.1973
Echinococcus granulosus histone lysine methyltransferase setb 0.003 0.0013 0.0007
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni jumonji domain containing protein 0.0078 0.0335 0.0323
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Toxoplasma gondii NADPH-glutathione reductase 0.0089 0.0414 0.0402
Plasmodium vivax thioredoxin reductase, putative 0.0257 0.1546 0.1535
Entamoeba histolytica hypothetical protein 0.034 0.2103 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0144
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0126
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0252 0.024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus Nuclear hormone receptor HR96 0.0051 0.0159 0.0154
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0038 0.0069 0.0057
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0569 0.291
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus tar DNA binding protein 0.0348 0.2154 0.215
Echinococcus granulosus Protein patched homolog 1 0.0042 0.0095 0.009
Brugia malayi Latrophilin receptor protein 2 0.0048 0.0138 0.0125
Trichomonas vaginalis esterase, putative 0.0112 0.0569 0.0637
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.014 0.0753 0.397
Brugia malayi intermediate filament protein 0.0228 0.1349 0.1339
Schistosoma mansoni RAR-like nuclear receptor 0.0109 0.0546 0.0534
Schistosoma mansoni ubiquitin-specific peptidase 45 (C19 family) 0.0038 0.0069 0.0057
Echinococcus granulosus smad 0.0059 0.0211 0.0205
Echinococcus granulosus ubiquitin specific protease 41 0.0038 0.0069 0.0064
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 24 0.0038 0.0069 0.0057
Echinococcus multilocularis smad 0.0059 0.0211 0.0198
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0047 0.0129 0.0371
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 5 (C19 family) 0.0038 0.0069 0.0057
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0057
Brugia malayi Niemann-Pick C1 protein precursor 0.0098 0.047 0.0458
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0041 0.0093 0.0161
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0079 0.0342 0.033
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0144
Trypanosoma brucei Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0078 0.0078
Toxoplasma gondii peptidylprolyl isomerase 0.0038 0.0071 0.0058
Trichomonas vaginalis ubiquitin specific protease, putative 0.0038 0.0069 0.0077
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0065 0.0252 0.1084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0031 0.0025 0.0028
Schistosoma mansoni transcription factor LCR-F1 0.034 0.2103 0.2093
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0099 0.0481 0.0469
Brugia malayi Smad1 0.0059 0.0211 0.0198
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Onchocerca volvulus 0.0228 0.1349 0.9147
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1229 0.8086 0.8084
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0014 0.0001
Trichomonas vaginalis PIKK family atypical protein kinase 0.0047 0.0129 0.0144
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0038 0.0069 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 30 (C19 family) 0.0038 0.0069 0.0057
Mycobacterium tuberculosis Probable hydrolase 0.0112 0.0569 0.0424
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Loa Loa (eye worm) thioredoxin reductase 0.0257 0.1546 0.1535
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0047 0.0129 0.0371
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0265 0.0253
Echinococcus granulosus thyroid hormone receptor alpha 0.0051 0.0159 0.0154
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0252 0.024
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0047 0.0129 0.0124
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.02 0.0188
Brugia malayi nuclear receptor RXR 0.0057 0.02 0.0188
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 36 0.0038 0.0069 0.0064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.1353 0.8926 1
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0265 0.0253
Echinococcus granulosus tumor protein p63 0.033 0.2033 0.2029
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0026
Echinococcus granulosus GA binding protein alpha chain 0.0079 0.0342 0.0337
Loa Loa (eye worm) hypothetical protein 0.0067 0.0265 0.0253
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.034 0.2103 0.2099
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0521 0.3323 0.3035
Echinococcus granulosus ubiquitin specific peptidase c family 0.0038 0.0069 0.0064
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 14 0.0038 0.0069 0.0057
Echinococcus granulosus lamin 0.0228 0.1349 0.1345
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0188
Echinococcus multilocularis ubiquitin specific peptidase (c family) ubiquitin terminal hydrolase 0.0038 0.0069 0.0057
Schistosoma mansoni steroid hormone receptor ad4bp 0.0109 0.0546 0.0534
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase family 2 protein 0.0038 0.0069 0.0057
Echinococcus multilocularis thioredoxin glutathione reductase 0.0257 0.1546 0.1535
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis lamin 0.0228 0.1349 0.1339
Toxoplasma gondii inorganic anion transporter, sulfate permease (SulP) family protein 0.0039 0.0078 0.0065
Onchocerca volvulus 0.0247 0.1474 1
Brugia malayi beta-lactamase 0.0112 0.0569 0.0557
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi PHD-finger family protein 0.003 0.0014 0.0001
Loa Loa (eye worm) RNA binding protein 0.0348 0.2154 0.2145
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Brugia malayi cytoplasmic intermediate filament protein 0.0122 0.0636 0.0624
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0206 0.1202 0.1191
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0047 0.0129 0.0371
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0051 0.0159 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0109 0.0546 0.0534
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0048 0.0138 0.0132
Entamoeba histolytica carbonic anhydrase, putative 0.0335 0.2068 0.9828
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Echinococcus granulosus mothers against decapentaplegic 5 0.0059 0.0211 0.0205
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Echinococcus multilocularis peregrin 0.003 0.0014 0.0001
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0093 0.008
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Plasmodium falciparum inorganic anion exchanger, inorganic anion antiporter 0.0039 0.0078 0.0064
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0265 0.0253
Entamoeba histolytica hypothetical protein 0.034 0.2103 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0065 0.0252 0.024
Schistosoma mansoni peptidase 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0051 0.0154 0.0514
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus Protein ultraspiracle homolog 0.0109 0.0546 0.3648
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0546 0.0534
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0569 0.0637
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 22 0.0038 0.0069 0.0057
Brugia malayi beta-lactamase family protein 0.0112 0.0569 0.0557
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Brugia malayi Pre-SET motif family protein 0.0206 0.1202 0.1191
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Leishmania major mitochondrial DNA polymerase beta 0.0295 0.1798 0.8654
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni tar DNA-binding protein 0.0348 0.2154 0.2145
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1798 1
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0109 0.0546 0.0534
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 20 0.0038 0.0069 0.0064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0093 0.0087
Schistosoma mansoni smad1 5 8 and 0.0059 0.0211 0.0198
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 13, putative 0.0038 0.0069 0.0055
Loa Loa (eye worm) jmjC domain-containing protein 0.0062 0.0228 0.0215
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Toxoplasma gondii thioredoxin reductase 0.0257 0.1546 0.1535
Brugia malayi jmjC domain containing protein 0.0036 0.0056 0.0044
Mycobacterium ulcerans bacterioferritin BfrA 0.0134 0.0718 0.0645
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0159 0.0146
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0051 0.0159 0.1001
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0122 0.0636 0.0624
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0064 0.0072
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0047 0.0129 0.0293
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0569 0.0557
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0109 0.0546 0.0534
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0252 0.0938
Echinococcus granulosus PHD finger protein rhinoceros 0.003 0.0014 0.0009
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus beta LACTamase domain containing family member 0.0112 0.0569 0.0564
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0569 0.0637
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni hypothetical protein 0.034 0.2103 0.2093
Loa Loa (eye worm) hypothetical protein 0.1513 1 1
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0069 0.0064
Mycobacterium tuberculosis Probable transmembrane carbonic anhydrase (carbonate dehydratase) (carbonic dehydratase) 0.0463 0.2934 0.3589
Echinococcus granulosus ferritin 0.0134 0.0718 0.0713
Schistosoma mansoni hypothetical protein 0.1229 0.8086 0.8084
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Brugia malayi Nuclear hormone receptor E75 0.0051 0.0159 0.0146
Mycobacterium leprae CARBONIC ANHYDRASE (CARBONATE DEHYDRATASE) (CARBONIC DEHYDRATASE) 0.0335 0.2068 0.1589
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0134 0.0718 0.0317
Schistosoma mansoni peptidase Clp (S14 family) 0.1513 1 1
Brugia malayi ubiquitin carboxyl-terminal hydrolase 46 0.0038 0.0069 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 4 (C19 family) 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) DR-78 0.0051 0.0159 0.0146
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 2, putative 0.0038 0.0069 0.0057
Schistosoma mansoni ferritin light chain 0.0134 0.0718 0.0706
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0051 0.0159 0.0146
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) glutathione reductase 0.0257 0.1546 0.1535
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis u4:u6.u5 tri snrnp associated protein 2 0.0038 0.0069 0.0057
Brugia malayi Nuclear hormone receptor-like 1 0.0057 0.02 0.0188
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0071 0.0036
Plasmodium falciparum ubiquitin specific protease, putative 0.0038 0.0069 0.0055
Schistosoma mansoni family C19 unassigned peptidase (C19 family) 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus 0.0109 0.0546 0.3648
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0064 0.0072
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0069 0.0064
Plasmodium falciparum glutathione reductase 0.0089 0.0414 0.04
Trichomonas vaginalis set domain proteins, putative 0.0235 0.1394 0.1562
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis lamin dm0 0.0228 0.1349 0.1339
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0057 0.02 0.0195
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni ubiquitin-specific peptidase 14 (C19 family) 0.0038 0.0069 0.0057
Loa Loa (eye worm) MH2 domain-containing protein 0.0866 0.5644 0.5639
Brugia malayi latrophilin 2 splice variant baaae 0.0104 0.0514 0.0502
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0228 0.1349 0.1339
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0112 0.0569 0.0495
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1513 1 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Schistosoma mansoni hypothetical protein 0.004 0.0085 0.0073
Brugia malayi Nuclear hormone receptor-like 1 0.0109 0.0546 0.0534
Schistosoma mansoni smad1 5 8 and 0.0059 0.0211 0.0198
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0414 0.2014
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0056 0.0044
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0112 0.0569 0.0424
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0038 0.0069 0.1378
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0089 0.0414 0.04
Brugia malayi steroid hormone receptor 0.0109 0.0546 0.0534
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis carbonic anhydrase II 0.0181 0.1031 0.1019
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0109 0.0546 0.0534
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 12 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0106 0.0527 0.0515
Brugia malayi CHE-14 protein 0.0042 0.0095 0.0083
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Brugia malayi Intermediate filament tail domain containing protein 0.0228 0.1349 0.1339
Toxoplasma gondii ubiquitin-specific protease USP4 0.0038 0.0069 0.0057
Toxoplasma gondii ABC1 family protein 0.0112 0.0569 0.0557
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0717 0.4641 0.5873
Schistosoma mansoni zinc finger protein 0.0051 0.0159 0.0146
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.011 0.0555 0.0543
Onchocerca volvulus 0.0112 0.0569 0.3807
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0109 0.0546 0.0534
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0065 0.0252 0.0239
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0992 0.649 0.8349
Schistosoma mansoni nuclear receptor 0.0051 0.0159 0.0146
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0051 0.0159 0.0146
Trypanosoma brucei carbonic anhydrase-like protein 0.0181 0.1031 0.5572
Leishmania major ubiqitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Echinococcus granulosus carbonic anhydrase 0.0067 0.0265 0.026
Entamoeba histolytica hypothetical protein 0.034 0.2103 1
Toxoplasma gondii isocitrate dehydrogenase 0.0065 0.0252 0.024
Echinococcus granulosus lamin dm0 0.0228 0.1349 0.1345
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0051 0.0159 0.0146
Echinococcus granulosus peregrin 0.003 0.0014 0.0009
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi MH1 domain containing protein 0.0033 0.0033 0.0021
Echinococcus granulosus intermediate filament protein 0.0228 0.1349 0.1345
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0521 0.3323 0.3314
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0064
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Mycobacterium ulcerans hypothetical protein 0.0112 0.0569 0.0495
Plasmodium falciparum thioredoxin reductase 0.0089 0.0414 0.04
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Echinococcus multilocularis peptidase Clp (S14 family) 0.0992 0.649 0.6486
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Echinococcus multilocularis Ubiquitin carboxyl terminal hydrolase 48 0.0038 0.0069 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Schistosoma mansoni hypothetical protein 0.0038 0.0069 0.0057
Schistosoma mansoni ubiquitin carboxyl-terminal hydrolase of the cysteine proteinase fold 0.0038 0.0069 0.0057
Onchocerca volvulus 0.0038 0.0069 0.0386
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0252 0.1084
Mycobacterium ulcerans lipase LipD 0.0112 0.0569 0.0495
Mycobacterium tuberculosis Conserved protein 0.0112 0.0569 0.0424
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0093 0.0161
Leishmania major carbonic anhydrase family protein, putative 0.0335 0.2068 1
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0047 0.0129 0.0321
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0295 0.1798 1
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0089 0.0414 0.2014
Plasmodium vivax hypothetical protein, conserved 0.003 0.0014 0.0001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0134 0.0718 0.0623
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0078 0.0078
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Mycobacterium ulcerans esterase/lipase LipP 0.0112 0.0569 0.0495
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0753 0.3435
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0521 0.3323 0.292
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0109 0.0546 0.0541
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0134 0.0718 0.0158
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0109 0.0546 0.0534
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 24 (C19 family) 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0188
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.1513 1 1
Loa Loa (eye worm) nuclear factor I 0.0033 0.0033 0.0021
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 12 0.0038 0.0069 0.0064
Trypanosoma cruzi hypothetical protein, conserved 0.0112 0.0569 0.291
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0051 0.0159 0.0146
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0109 0.0546 0.0534
Leishmania major trypanothione reductase 0.0257 0.1546 0.7394
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus Alhambra homolog 0.003 0.0014 0.0009
Schistosoma mansoni Smad4 0.0059 0.0211 0.0198
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0067 0.0265 0.0253
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Trypanosoma brucei trypanothione reductase 0.0257 0.1546 0.8544
Loa Loa (eye worm) hypothetical protein 0.0051 0.0157 0.0145
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.1031 0.5572
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Echinococcus multilocularis ubiquitin specific protease 41 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi nuclear receptor NHR-88 0.0109 0.0546 0.0534
Schistosoma mansoni tar DNA-binding protein 0.0348 0.2154 0.2145
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Echinococcus multilocularis protein dispatched 1 0.0048 0.0135 0.0123
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis expressed protein 0.0038 0.0069 0.0057
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0041 0.0093 0.0161
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0065 0.0252 0.1084
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium ulcerans carbonic anhydrase 0.0335 0.2068 0.2006
Echinococcus multilocularis Niemann Pick C1 protein 0.0139 0.0752 0.0741
Mycobacterium tuberculosis Probable conserved transmembrane protein 0.0285 0.1732 0.198
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0112 0.0569 0.0557
Schistosoma mansoni hypothetical protein 0.003 0.0014 0.0001
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0104 0.0514 0.0502
Brugia malayi nuclear receptor RXR 0.0051 0.0159 0.0146
Plasmodium vivax glutathione reductase, putative 0.0257 0.1546 0.1535
Brugia malayi MH1 domain containing protein 0.0059 0.0211 0.0198
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Echinococcus granulosus cytoplasmic intermediate filament protein 0.011 0.0555 0.055
Onchocerca volvulus 0.0048 0.0138 0.086
Schistosoma mansoni smad 0.0059 0.0211 0.0198
Brugia malayi MH1 domain containing protein 0.0059 0.0211 0.0198
Mycobacterium tuberculosis Probable lipase LipD 0.0112 0.0569 0.0424
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0089 0.0414 0.0402
Echinococcus granulosus thioredoxin glutathione reductase 0.0257 0.1546 0.1541
Loa Loa (eye worm) ubiquitin specific peptidase 39 0.0038 0.0069 0.0057
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0109 0.0546 0.0534
Giardia lamblia Hypothetical protein 0.0038 0.0069 0.1378
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0295 0.1798 1
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0109 0.0546 0.0534
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0064
Schistosoma mansoni calpain-7 (C02 family) 0.0038 0.0069 0.0057
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Trichomonas vaginalis ubiquitin specific protease, putative 0.0038 0.0069 0.0077
Brugia malayi Thioredoxin reductase 0.0257 0.1546 0.1535
Brugia malayi hypothetical protein 0.034 0.2103 0.2093
Schistosoma mansoni calpain-7 (C02 family) 0.0038 0.0069 0.0057
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0265 0.0253
Mycobacterium tuberculosis Probable reductase 0.0587 0.3765 0.4702
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0048 0.0138 0.0125
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Schistosoma mansoni coup transcription factor 0.0109 0.0546 0.0534
Brugia malayi hypothetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni family C19 non-peptidase homologue (C19 family) 0.0038 0.0069 0.0057
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0089 0.0414 0.2014
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0067 0.0265 0.0253
Onchocerca volvulus 0.0228 0.1349 0.9147
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Loa Loa (eye worm) MH1 domain-containing protein 0.0059 0.0211 0.0198
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0089 0.0414 0.0338
Toxoplasma gondii PHD-finger domain-containing protein 0.003 0.0014 0.0001
Schistosoma mansoni tar DNA-binding protein 0.0348 0.2154 0.2145
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0546 0.0534
Brugia malayi MH1 domain containing protein 0.0033 0.0033 0.0021
Brugia malayi hypothetical protein 0.0038 0.0069 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trypanosoma cruzi carbonic anhydrase-like protein, putative 0.0181 0.1031 0.5572
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0587 0.3765 0.4702
Mycobacterium tuberculosis Probable lipase LipE 0.0112 0.0569 0.0424
Echinococcus granulosus expressed protein 0.0134 0.0718 0.0713
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 36 0.0038 0.0069 0.0057
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.1513 1 1
Echinococcus granulosus GPCR family 2 0.0048 0.0138 0.0132
Trichomonas vaginalis PIKK family atypical protein kinase 0.004 0.0083 0.0093
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0098 0.047 0.0465
Mycobacterium ulcerans beta-lactamase 0.0112 0.0569 0.0495
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0065 0.0252 0.0247
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma cruzi cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi peptidyl-prolyl cis-trans isomerase 0.0038 0.0071 0.0036
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0265 0.0253
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0348 0.2154 0.2145
Schistosoma mansoni hypothetical protein 0.0104 0.0514 0.0502
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0038 0.0069 0.1378
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 7 0.0038 0.0069 0.0057
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0546 0.0534
Loa Loa (eye worm) hypothetical protein 0.0042 0.0095 0.0083
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0055
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0109 0.0546 0.0534
Schistosoma mansoni hypothetical protein 0.004 0.0085 0.0073
Echinococcus granulosus Niemann Pick C1 protein 0.0139 0.0752 0.0747
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0265 0.0253
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 0.0038 0.0069 0.0057
Brugia malayi TAR-binding protein 0.0348 0.2154 0.2145
Echinococcus granulosus sterol regulatory element binding protein 0.0042 0.0095 0.009
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0569 0.0637
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0039 0.0077 0.0064
Trichomonas vaginalis ubiquitin specific protease, putative 0.0038 0.0069 0.0077
Brugia malayi hypothetical protein 0.0057 0.02 0.0188
Echinococcus multilocularis beta LACTamase domain containing family member 0.0112 0.0569 0.0557
Mycobacterium tuberculosis Beta-carbonic anhydrase 0.1175 0.7724 1
Brugia malayi Fli-1 protein 0.0238 0.1418 0.1408
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0041 0.0093 0.0161
Brugia malayi Carbonic anhydrase like protein 2 precursor 0.0067 0.0265 0.0253
Trichomonas vaginalis penicillin-binding protein, putative 0.0112 0.0569 0.0637
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trichomonas vaginalis D-aminoacylase, putative 0.0112 0.0569 0.0637
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 22 0.0038 0.0069 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0038 0.0069 0.0057
Echinococcus granulosus u4:u6.u5 tri snrnp associated protein 2 0.0038 0.0069 0.0064
Plasmodium falciparum U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0038 0.0069 0.0055
Brugia malayi MH2 domain containing protein 0.0866 0.5644 0.5639
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 1, putative 0.0038 0.0069 0.0057
Trichomonas vaginalis glutathione reductase, putative 0.0089 0.0414 0.0464
Schistosoma mansoni ferritin 0.0134 0.0718 0.0706
Brugia malayi hypothetical protein 0.0051 0.0159 0.0146
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0109 0.0546 0.0534
Echinococcus multilocularis sterol regulatory element binding protein 0.0042 0.0095 0.0083
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0109 0.0546 0.0534
Schistosoma mansoni ubiquitin-specific peptidase 44 (C19 family) 0.0038 0.0069 0.0057
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0089 0.0414 0.1743
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Echinococcus multilocularis expressed protein 0.0134 0.0718 0.0706
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis musashi 0.0228 0.1349 0.1339
Schistosoma mansoni ubiquitin-specific peptidase 16 (C19 family) 0.0038 0.0069 0.0057
Schistosoma mansoni ubiquitin-specific peptidase 7 (C19 family) 0.0038 0.0069 0.0057
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis ecdysone induced protein 78C 0.0109 0.0546 0.0534
Toxoplasma gondii hypothetical protein 0.0521 0.3323 0.3315
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0055
Brugia malayi MH2 domain containing protein 0.0059 0.0211 0.0198
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) intermediate filament protein 0.0228 0.1349 0.1339
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0089 0.0414 0.0409
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.003 0.0014 0.0001
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0089 0.0414 0.0216
Echinococcus multilocularis FTZ F1 alpha 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0257 0.1546 0.1731
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0038 0.0069 0.0057
Brugia malayi photoreceptor-specific nuclear receptor 0.0109 0.0546 0.0534
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0057 0.02 0.0188
Brugia malayi Putative carbonic anhydrase 5 precursor 0.0181 0.1031 0.1019
Brugia malayi Eukaryotic-type carbonic anhydrase family protein 0.0181 0.1031 0.1019
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0038 0.0069 0.0077
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.1743
Echinococcus granulosus 5'partial|Ubiquitin carboxyl terminal hydrolase 48 0.0038 0.0069 0.0064
Echinococcus granulosus FTZ F1 alpha 0.0109 0.0546 0.0541
Echinococcus multilocularis isocitrate dehydrogenase 0.0065 0.0252 0.024
Loa Loa (eye worm) hypothetical protein 0.0067 0.0265 0.0253
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis PHD finger protein rhinoceros 0.003 0.0014 0.0001
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0089 0.0414 0.0402
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0109 0.0546 0.0534
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0134 0.0718 0.0623
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 14 0.0038 0.0069 0.0064
Onchocerca volvulus 0.0112 0.0569 0.3807
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0252 0.024
Giardia lamblia NADH oxidase lateral transfer candidate 0.0089 0.0414 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0109 0.0546 0.0541
Schistosoma mansoni cellular tumor antigen P53 0.0048 0.0138 0.0126
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1229 0.8086 0.8085
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Loa Loa (eye worm) nuclear receptor NHR-67 0.0051 0.0159 0.0146
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0652 0.4206 0.5292
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0089 0.0414 0.0338
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0057
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0098 0.047 0.0458
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0109 0.0546 0.0534
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trypanosoma cruzi Sulfate transporter N-terminal domain with GLY motif/Sulfate transporter family, putative 0.0039 0.0078 0.0078
Onchocerca volvulus 0.0051 0.0159 0.1001
Schistosoma mansoni nuclear receptor 0.0051 0.0159 0.0146
Schistosoma mansoni ets-related 0.0238 0.1418 0.1408
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.1031 0.1019
Brugia malayi MH2 domain containing protein 0.0059 0.0211 0.0198
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Echinococcus multilocularis tar DNA binding protein 0.0348 0.2154 0.2145
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.011 0.0555 0.0543
Plasmodium vivax ubiquitin specific protease, putative 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0038 0.0069 0.0064
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Echinococcus granulosus carbonic anhydrase 0.0067 0.0265 0.026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0064 0.0072
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0109 0.0546 0.0541
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0038 0.0069 0.0077
Brugia malayi jmjC domain containing protein 0.0098 0.047 0.0458
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) MH2 domain-containing protein 0.0059 0.0211 0.0198
Mycobacterium tuberculosis Conserved hypothetical protein 0.0155 0.0859 0.0812
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0112 0.0569 0.0557
Brugia malayi nuclear receptor NHR-67 0.0051 0.0159 0.0146
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Brugia malayi beta-lactamase family protein 0.0112 0.0569 0.0557
Schistosoma mansoni hypothetical protein 0.004 0.0085 0.0073
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0064 0.0072
Plasmodium vivax U4/U6.U5 tri-snRNP-associated protein 2, putative 0.0038 0.0069 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0002 0.0002
Loa Loa (eye worm) jmjC domain-containing protein 0.0036 0.0056 0.0044
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0057 0.02 0.0188
Echinococcus granulosus ecdysone induced protein 78C 0.0109 0.0546 0.0541
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Echinococcus granulosus carbonic anhydrase 0.0067 0.0265 0.026
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0065 0.0252 0.024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis expressed protein 0.0039 0.0077 0.0064
Schistosoma mansoni ubiquitin-specific peptidase 9X (C19 family) 0.0038 0.0069 0.0057
Echinococcus multilocularis ubiquitin specific peptidase 42 (C19 family) 0.0038 0.0069 0.0057
Leishmania major carbonic anhydrase-like protein 0.0181 0.1031 0.4822
Brugia malayi glutathione reductase 0.0257 0.1546 0.1535
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0047 0.0129 0.0321
Schistosoma mansoni nuclear hormone receptor 0.0051 0.0159 0.0146
Schistosoma mansoni hypothetical protein 0.0048 0.0138 0.0125
Schistosoma mansoni ubiquitin-specific peptidase 48 (C19 family) 0.0038 0.0069 0.0057
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0057 0.02 0.0188
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi RNA recognition motif domain containing protein 0.0348 0.2154 0.2145
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0188
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 46 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0109 0.0546 0.3648
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0109 0.0546 0.0534
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0587 0.3765 0.3389
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0064 0.0072
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0064
Schistosoma mansoni carbonic anhydrase 0.0335 0.2068 0.2058
Plasmodium falciparum thioredoxin reductase 0.0257 0.1546 0.1534
Plasmodium falciparum carbonic anhydrase 0.0067 0.0265 0.0252
Brugia malayi ecdysteroid receptor 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Probable dehydrogenase 0.0587 0.3765 0.4702
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 24 0.0038 0.0069 0.0064
Onchocerca volvulus Bile acid receptor homolog 0.0109 0.0546 0.3648
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0109 0.0546 0.0534
Echinococcus granulosus TGF beta signal transducer SmadC 0.0059 0.0211 0.0205
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Echinococcus granulosus expressed conserved protein 0.0092 0.0431 0.0426
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni ubiquitin-specific peptidase 46 (C19 family) 0.0038 0.0069 0.0057
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0152 0.0838 0.0827
Echinococcus granulosus lysine specific demethylase 5A 0.0036 0.0056 0.0051
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.1513 1 1
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0089 0.0414 0.1743
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0042 0.0095 0.0083
Trypanosoma cruzi trypanothione reductase, putative 0.0257 0.1546 0.8544
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Schistosoma mansoni apoferritin-2 0.0134 0.0718 0.0706
Schistosoma mansoni ferritin 0.0134 0.0718 0.0706
Schistosoma mansoni hypothetical protein 0.0048 0.0138 0.0125
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0051 0.0159 0.1001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0089 0.0414 0.0338
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0109 0.0546 0.0534
Echinococcus multilocularis Niemann Pick C1 protein 0.0098 0.047 0.0458
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0992 0.649 0.8349
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0089 0.0414 0.2014
Schistosoma mansoni lamin 0.0228 0.1349 0.1339
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Schistosoma mansoni carbonic anhydrase II (carbonate dehydratase II) 0.0181 0.1031 0.1019
Loa Loa (eye worm) transcription factor SMAD2 0.0866 0.5644 0.5639
Loa Loa (eye worm) hypothetical protein 0.0224 0.1321 0.131
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0652 0.4206 0.5292
Brugia malayi Steroid receptor seven-up type 2 0.0109 0.0546 0.0534
Schistosoma mansoni lamin 0.0228 0.1349 0.1339
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0089 0.0414 0.0402
Echinococcus multilocularis tumor protein p63 0.033 0.2033 0.2023
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0089 0.0414 0.0402
Brugia malayi nuclear hormone receptor 0.0109 0.0546 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0035 0.0048 0.0054
Echinococcus granulosus nuclear receptor nhr 48 0.0051 0.0159 0.0154
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0057
Brugia malayi nuclear receptor NHR-88 0.0051 0.0159 0.0146
Schistosoma mansoni hypothetical protein 0.0067 0.0265 0.0253
Entamoeba histolytica hypothetical protein 0.034 0.2103 1
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0112 0.0569 0.0424
Echinococcus granulosus carbonic anhydrase II 0.0181 0.1031 0.1026
Trypanosoma brucei hypothetical protein, conserved 0.0112 0.0569 0.291
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni apoferritin-2 0.0134 0.0718 0.0706
Loa Loa (eye worm) hypothetical protein 0.0112 0.0569 0.0557
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.1743
Trypanosoma brucei cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0026
Brugia malayi Isocitrate dehydrogenase 0.0065 0.0252 0.024
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0089 0.0414 0.0402
Mycobacterium tuberculosis Beta-carbonic anhydrase CanB 0.0156 0.0866 0.0821
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase 13, putative 0.0038 0.0069 0.0057
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0112 0.0569 0.0424
Toxoplasma gondii target of rapamycin (TOR), putative 0.0035 0.0048 0.0035
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 14 0.0038 0.0069 0.1378
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0188
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Trichomonas vaginalis rotamase, putative 0.0038 0.0071 0.0079
Toxoplasma gondii ubiquitin specific protease 39 isoform 2, putative 0.0038 0.0069 0.0057
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0065 0.0252 0.1084
Mycobacterium tuberculosis Conserved protein 0.0112 0.0569 0.0424
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0992 0.649 0.6279
Schistosoma mansoni retinoic acid receptor RXR 0.0109 0.0546 0.0534
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.014 0.0753 0.397
Entamoeba histolytica peptidyl-prolyl cis-trans isomerase, putative 0.0038 0.0071 0.0009
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 47 0.0038 0.0069 0.0064
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Plasmodium falciparum glutathione reductase 0.0257 0.1546 0.1534
Loa Loa (eye worm) hypothetical protein 0.0228 0.1349 0.1339
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0414 0.2014
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0051 0.0159 0.0154
Trichomonas vaginalis Harbinger-1_Harbinger/PIFA2 transposable element protein 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0109 0.0546 0.0534
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0057 0.02 0.0188
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Onchocerca volvulus 0.0112 0.0569 0.3807
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 7 0.0038 0.0069 0.0064
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0109 0.0546 0.0534
Brugia malayi ecdysone receptor 0.0051 0.0159 0.0146
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis protein patched 0.0042 0.0095 0.0083
Loa Loa (eye worm) eukaryotic-type carbonic anhydrase 0.0181 0.1031 0.1019
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0039 0.0077 0.0064
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Schistosoma mansoni nuclear receptor nhr-48 0.0051 0.0159 0.0146
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0065 0.0254 0.0242
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0051 0.0159 0.0154
Loa Loa (eye worm) Smad1 0.0059 0.0211 0.0198
Schistosoma mansoni thyroid hormone receptor 0.1337 0.8819 0.8817
Leishmania major hypothetical protein, conserved 0.0112 0.0569 0.2518
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0038 0.0071 0.0036
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0018 0.002
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 5 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Toxoplasma gondii hypothetical protein 0.0038 0.0069 0.0057
Echinococcus granulosus expressed protein 0.0039 0.0077 0.0072
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0109 0.0546 0.0541
Toxoplasma gondii hypothetical protein 0.0067 0.0265 0.0253
Echinococcus multilocularis thyroid hormone receptor alpha 0.1337 0.8819 0.8817
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0002 0.0002
Onchocerca volvulus 0.0038 0.0069 0.0386
Loa Loa (eye worm) ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Onchocerca volvulus 0.0235 0.1394 0.9453
Brugia malayi Nuclear hormone receptor E75 0.0051 0.0159 0.0146
Loa Loa (eye worm) carbonic anhydrase 3 0.0181 0.1031 0.1019
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Loa Loa (eye worm) nuclear hormone receptor 0.0051 0.0159 0.0146
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni ubiquitin-specific peptidase 10 (C19 family) 0.0038 0.0069 0.0057
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0089 0.0414 0.04
Echinococcus multilocularis GPCR, family 2 0.0048 0.0138 0.0125
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Mycobacterium tuberculosis Conserved protein 0.0112 0.0569 0.0424
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0047 0.0129 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0048 0.0138 0.0125
Schistosoma mansoni tar DNA-binding protein 0.0348 0.2154 0.2145
Loa Loa (eye worm) hypothetical protein 0.0106 0.0527 0.0515
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis PIKK family atypical protein kinase 0.0028 0.0002 0.0002
Toxoplasma gondii UBA/TS-N domain-containing protein 0.0038 0.0069 0.0057
Giardia lamblia DUB-1 0.0038 0.0069 0.1378
Loa Loa (eye worm) hypothetical protein 0.0033 0.0033 0.0021
Brugia malayi tailless protein 0.0051 0.0159 0.0146
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 0.0038 0.0069 0.0064
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0109 0.0546 0.0541
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 16 0.0038 0.0069 0.0064
Echinococcus multilocularis nuclear receptor nhr 48 0.0051 0.0159 0.0146
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0098 0.047 0.0458
Schistosoma mansoni ferritin 0.0134 0.0718 0.0706
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0048 0.0138 0.0125
Loa Loa (eye worm) TAR-binding protein 0.0348 0.2154 0.2145
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni carbonic anhydrase-related 0.0067 0.0265 0.0253
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0089 0.0414 0.2014
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Schistosoma mansoni ferritin 0.0134 0.0718 0.0706
Loa Loa (eye worm) phosphatidylinositol 3 0.0047 0.0129 0.0116
Giardia lamblia GTOR 0.0047 0.0129 0.2871
Echinococcus multilocularis GA binding protein alpha chain 0.0079 0.0342 0.033
Loa Loa (eye worm) steroid hormone receptor 0.0109 0.0546 0.0534
Echinococcus multilocularis lysine specific demethylase 5A 0.0036 0.0056 0.0044
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Schistosoma mansoni tar DNA-binding protein 0.0348 0.2154 0.2145
Echinococcus multilocularis Smad4 0.0059 0.0211 0.0198
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.1513 1 1
Leishmania major peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative 0.0038 0.0071 0.0031
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0109 0.0546 0.0534
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 23 0.0038 0.0069 0.0064
Schistosoma mansoni smad1 5 8 and 0.0059 0.0211 0.0198
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0051 0.0159 0.0146
Trichomonas vaginalis mercuric reductase, putative 0.0089 0.0414 0.0464
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0051 0.0159 0.0146
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0048 0.0138 0.0132
Schistosoma mansoni rotamase 0.0039 0.0077 0.0064
Brugia malayi RNA binding protein 0.0348 0.2154 0.2145
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0051 0.0159 0.0146
Onchocerca volvulus 0.0051 0.0159 0.1001
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Schistosoma mansoni thyroid hormone receptor 0.1337 0.8819 0.8817
Schistosoma mansoni jumonji/arid domain-containing protein 0.0036 0.0056 0.0044
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0065 0.0252 0.024
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0047 0.0129 0.0293
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Trypanosoma brucei Peptidase C19, ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Mycobacterium ulcerans bacterioferritin BfrB 0.0134 0.0718 0.0645
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0065 0.0254 0.0242
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0048 0.0138 0.0125
Trichomonas vaginalis conserved hypothetical protein 0.0042 0.0095 0.0107
Brugia malayi Calcitonin receptor-like protein seb-1 0.0152 0.0838 0.0827
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0067 0.0265 0.0253
Plasmodium vivax ubiquitin carboxyl-terminal hydrolase family 2, putative 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Plasmodium vivax hypothetical protein, conserved 0.0112 0.0569 0.0557
Onchocerca volvulus 0.0038 0.0069 0.0386
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 14 0.0038 0.0069 0.0055
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Trypanosoma cruzi ubiquitin hydrolase, putative 0.0038 0.0069 0.0026
Schistosoma mansoni ubiquitin-specific peptidase 22 (C19 family) 0.0038 0.0069 0.0057
Schistosoma mansoni ferritin light chain 0.0134 0.0718 0.0706
Brugia malayi nuclear hormone receptor 0.0051 0.0159 0.0146
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 47 0.0038 0.0069 0.0057
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0065 0.0252 0.024
Loa Loa (eye worm) hypothetical protein 0.0109 0.0546 0.0534
Plasmodium vivax hypothetical protein, conserved 0.0038 0.0069 0.0057
Echinococcus multilocularis ferritin 0.0134 0.0718 0.0706
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0051 0.0159 0.0146
Brugia malayi nuclear hormone receptor family member nhr-6 0.0051 0.0159 0.0146
Mycobacterium tuberculosis Probable esterase LipL 0.0112 0.0569 0.0424
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0152 0.0838 0.0827
Brugia malayi ubiquitin specific protease 14 0.0038 0.0069 0.0057
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) latrophilin receptor protein 2 0.0048 0.0138 0.0125
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus multilocularis mothers against decapentaplegic 5 0.0059 0.0211 0.0198
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0038 0.0069 0.0057
Onchocerca volvulus Putative sulfate transporter 0.0247 0.1474 1
Schistosoma mansoni hypothetical protein 0.0048 0.0138 0.0125
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0089 0.0414 0.2014
Trichomonas vaginalis conserved hypothetical protein 0.0038 0.0069 0.0077
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0109 0.0546 0.0541
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Loa Loa (eye worm) hypothetical protein 0.0057 0.02 0.0188
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0109 0.0546 0.0534
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0587 0.3765 0.4702
Mycobacterium ulcerans hypothetical protein 0.0155 0.0859 0.0787
Loa Loa (eye worm) hypothetical protein 0.0067 0.0265 0.0253
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0652 0.4206 0.3857
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0038 0.0069 0.0057
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.1513 1 1
Echinococcus multilocularis carbonic anhydrase 0.0067 0.0265 0.0253
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0047 0.0129 0.0371
Schistosoma mansoni hypothetical protein 0.0048 0.0138 0.0125
Plasmodium falciparum ubiquitin carboxyl-terminal hydrolase 2, putative 0.0038 0.0069 0.0055
Brugia malayi Bromodomain containing protein 0.003 0.0014 0.0001
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 4 0.0038 0.0069 0.0057
Loa Loa (eye worm) PHD-finger family protein 0.003 0.0014 0.0001
Loa Loa (eye worm) hypothetical protein 0.0038 0.0069 0.0057
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0047 0.0129 0.0116
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Echinococcus granulosus peptidase Clp S14 family 0.0992 0.649 0.6489
Toxoplasma gondii ubiquitin carboxyl-terminal hydrolase 0.0038 0.0069 0.0057
Brugia malayi isocitrate dehydrogenase 0.0065 0.0252 0.024
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0109 0.0546 0.0534
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0038 0.0069 0.0026
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0521 0.3323 0.3315
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0038 0.0069 0.0077
Loa Loa (eye worm) hypothetical protein 0.0051 0.0159 0.0146
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0038 0.0069 0.0023

Activities

Activity type Activity value Assay description Source Reference
Ki (binding) = 0.96 nM Inhibition of human recombinant CA2 by stopped flow CO2 hydration assay ChEMBL. 19438226
Ki (binding) = 5.2 nM Inhibition of human recombinant CA1 by stopped flow CO2 hydration assay ChEMBL. 19438226
Ki (binding) = 12.3 nM Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv1284 by by stopped flow CO2 hydration assay ChEMBL. 19438226
Ki (binding) = 53 nM inhibition of Candida albicans recombinant Nce103 after 15 mins by stopped-flow CO2 hydration assay ChEMBL. 20299219
Ki (binding) = 85 nM Inhibition of Mycobacterium tuberculosis recombinant carbonic anhydrase Rv3273 by by stopped flow CO2 hydration assay ChEMBL. 19438226
Kinact (binding) = 8.8 nM Inhibition of human CA9 catalytic domain by CO2 hydration stopped-flow assay ChEMBL. 19410461
Kinact (binding) = 12.3 nM Inhibition of human recombinant CA1 by CO2 hydration stopped-flow assay ChEMBL. 19410461
Kinact (binding) = 85 nM Inhibition of human recombinant CA2 by CO2 hydration stopped-flow assay ChEMBL. 19410461
Kinact (binding) = 5680 nM Inhibition of human CA12 catalytic domain by CO2 hydration stopped-flow assay ChEMBL. 19410461

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

3 literature references were collected for this gene.

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