Detailed information for compound 1007801

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 264.32 | Formula: C14H20N2O3
  • H donors: 2 H acceptors: 2 LogP: 1.4 Rotable bonds: 2
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cc(ccc1O)C1=NC(C(N1O)(C)C)(C)C
  • InChi: 1S/C14H20N2O3/c1-13(2)14(3,4)16(18)12(15-13)9-6-7-10(17)11(8-9)19-5/h6-8,17-18H,1-5H3
  • InChiKey: ZXFQRIWOBDIJQD-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trichomonas vaginalis ran, putative 0.0043 0.0108 0.0305
Chlamydia trachomatis biotin carboxylase 0.0057 0.0162 0.0463
Brugia malayi prolyl oligopeptidase family protein 0.017 0.0603 0.339
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0095 0.0312 0.0308
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0778
Echinococcus multilocularis Dipeptidyl peptidase 9 0.0057 0.0164 0.0159
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.0057 0.0163 0.0469
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Echinococcus granulosus peptidase Clp S14 family 0.0052 0.0145 0.0531
Loa Loa (eye worm) prolyl oligopeptidase 0.017 0.0603 0.2536
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0143 0.2094
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Mycobacterium tuberculosis NADH-dependent enoyl-[acyl-carrier-protein] reductase InhA (NADH-dependent enoyl-ACP reductase) 0.0765 0.2922 1
Entamoeba histolytica hypothetical protein 0.0047 0.0125 0.736
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.002 0.0074
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0778
Toxoplasma gondii LsmAD domain-containing protein 0.0025 0.004 0.0042
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0143 0.0399
Schistosoma mansoni trimeric G-protein alpha o subunit 0.002 0.002 0.0074
Echinococcus multilocularis PHD finger protein rhinoceros 0.0029 0.0054 0.005
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0052 0.0145 0.0407
Mycobacterium tuberculosis Probable acetyl-/propionyl-coenzyme A carboxylase alpha chain (alpha subunit) AccA2: biotin carboxylase + biotin carboxyl carrie 0.0062 0.0184 0.0541
Leishmania major hypothetical protein, conserved 0.0074 0.0229 0.365
Trypanosoma cruzi trypanothione reductase, putative 0.0038 0.009 0.2031
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0016
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0778
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0074 0.0229 0.0695
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.0093
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0163 0.0429
Entamoeba histolytica Ran family GTPase 0.0043 0.0108 0.6174
Schistosoma mansoni hypothetical protein 0.0029 0.0054 0.0205
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0065
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0065
Plasmodium vivax hypothetical protein, conserved 0.0029 0.0054 0.0051
Trypanosoma brucei acetyl-CoA carboxylase 0.0164 0.0579 1
Echinococcus multilocularis jumonji domain containing protein 0.0041 0.0099 0.0094
Echinococcus multilocularis mixed lineage leukemia protein mll 0.0025 0.0037 0.0032
Brugia malayi Importin beta-1 subunit 0.0058 0.0168 0.0928
Loa Loa (eye worm) carboxyl transferase domain-containing protein 0.0158 0.0556 0.2338
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.017 0.0493
Onchocerca volvulus 0.0074 0.0229 0.1139
Echinococcus granulosus Smad4 0.0024 0.0036 0.0119
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.002 0.0015
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0062 0.0184 0.5074
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0038 0.009 0.0216
Schistosoma mansoni dipeptidyl-peptidase 9 (S09 family) 0.0057 0.0164 0.0615
Trypanosoma brucei oxidoreductase-like protein 0.0052 0.0143 0.2094
Trypanosoma brucei inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0088 0.1102
Schistosoma mansoni survival motor neuron protein 0.005 0.0137 0.0516
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.047 0.1771 0.6651
Treponema pallidum exodeoxyribonuclease (exoA) 0.0057 0.0163 0.5617
Plasmodium falciparum 3-oxoacyl-[acyl-carrier-protein] reductase 0.0052 0.0143 0.0359
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Mycobacterium ulcerans oxidoreductase 0.0052 0.0143 0.0399
Brugia malayi beta-lactamase 0.0074 0.0229 0.127
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.017 0.064
Schistosoma mansoni jumonji domain containing protein 0.0076 0.0236 0.0887
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0143 0.0399
Toxoplasma gondii hypothetical protein 0.0028 0.0048 0.0072
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0135
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.003 0.0058 0.0202
Mycobacterium tuberculosis Conserved protein 0.0074 0.0229 0.0695
Echinococcus granulosus geminin 0.0698 0.266 1
Onchocerca volvulus 0.0052 0.0143 0.0672
Brugia malayi hypothetical protein 0.0247 0.0903 0.5087
Brugia malayi hypothetical protein 0.0025 0.004 0.0199
Schistosoma mansoni 3-oxoacyl-[ACP] reductase 0.0052 0.0143 0.0537
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0143 0.3744
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0057 0.0163 1
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0253 0.0778
Brugia malayi Calcitonin receptor-like protein seb-1 0.0051 0.0141 0.0774
Schistosoma mansoni ap endonuclease 0.0057 0.0163 0.0613
Trypanosoma brucei trypanothione reductase 0.0038 0.009 0.1136
Echinococcus granulosus GTP binding nuclear protein Ran 0.0043 0.0108 0.0391
Leishmania major 3-oxoacyl-ACP reductase, putative 0.0052 0.0143 0.2094
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0229 0.6524
Onchocerca volvulus 0.0028 0.0051 0.0169
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0074 0.0229 0.0695
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0189 0.071
Leishmania major dehydrogenase/oxidoreductase-like protein 0.0052 0.0143 0.2094
Mycobacterium ulcerans 20-beta-hydroxysteroid dehydrogenase FabG3 0.0052 0.0143 0.0399
Echinococcus granulosus expressed protein 0.002 0.002 0.0058
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0057 0.0163 0.0598
Schistosoma mansoni subfamily S9B unassigned peptidase (S09 family) 0.017 0.0603 0.2267
Brugia malayi beta-lactamase family protein 0.0074 0.0229 0.127
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0034 0.0074 0.0277
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0229 0.072
Trypanosoma brucei Dipeptidyl-peptidase 8-like, putative 0.0057 0.0164 0.247
Brugia malayi PHD-finger family protein 0.0029 0.0054 0.0283
Mycobacterium leprae Probable bifunctional protein acetyl-/propionyl-coenzyme A carboxylase, alpha chain AccA3 (BccP) 0.0062 0.0184 0.0541
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.047 0.1771 0.6657
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.002 0.0074
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0043 0.0108 0.0238
Schistosoma mansoni peptidase Clp (S14 family) 0.008 0.0253 0.095
Echinococcus multilocularis beta LACTamase domain containing family member 0.0074 0.0229 0.0224
Echinococcus multilocularis acetyl coenzyme A carboxylase 1 0.0164 0.0579 0.0575
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0168 0.2553
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.002 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0108 0.2619
Loa Loa (eye worm) hypothetical protein 0.005 0.0135 0.0555
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0143 0.0399
Trypanosoma brucei PAB1-binding protein , putative 0.0025 0.004 0.022
Echinococcus multilocularis tar DNA binding protein 0.0063 0.0188 0.0184
Toxoplasma gondii pyruvate carboxylase 0.0062 0.0184 0.0541
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0062 0.0184 0.2839
Brugia malayi MH2 domain containing protein 0.0358 0.1334 0.7527
Brugia malayi Guanine nucleotide-binding protein alpha-6 subunit, putative 0.002 0.002 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.0182 0.0648 0.2165
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0189 0.071
Mycobacterium ulcerans pyruvate carboxylase 0.0062 0.0184 0.0541
Wolbachia endosymbiont of Brugia malayi enoyl-ACP reductase 0.0765 0.2922 1
Echinococcus granulosus importin subunit beta 1 0.0058 0.0168 0.0617
Loa Loa (eye worm) thioredoxin reductase 0.0038 0.009 0.0363
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.002 0.0058
Mycobacterium tuberculosis Probable 3-oxoacyl-[acyl-carrier protein] reductase FabG2 (3-ketoacyl-acyl carrier protein reductase) 0.0052 0.0143 0.0399
Brugia malayi Carboxyl transferase domain containing protein 0.0158 0.0556 0.3125
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Trypanosoma cruzi hypothetical protein, conserved 0.0074 0.0229 0.6524
Echinococcus granulosus smad 0.0024 0.0036 0.0119
Mycobacterium leprae POSSIBLE OXIDOREDUCTASE 0.0052 0.0143 0.0399
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0065
Loa Loa (eye worm) hypothetical protein 0.0052 0.0143 0.0587
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0043 0.0108 0.0104
Echinococcus granulosus acetyl coenzyme A carboxylase 1 0.0164 0.0579 0.2163
Chlamydia trachomatis oxoacy-ACP reductase 0.0052 0.0143 0.0399
Brugia malayi Guanine nucleotide-binding protein alpha-12 subunit, putative 0.002 0.002 0.0087
Echinococcus granulosus thioredoxin glutathione reductase 0.0039 0.0092 0.033
Echinococcus granulosus gtp binding protein I alpha 1subunit 0.002 0.002 0.0058
Mycobacterium leprae NADH-DEPENDENT ENOYL-[ACYL-CARRIER-PROTEIN] REDUCTASE INHA (NADH-DEPENDENT ENOYL-ACP REDUCTASE) 0.0765 0.2922 1
Brugia malayi Pre-SET motif family protein 0.0432 0.1624 0.9168
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0088 0.197
Brugia malayi RNA, U transporter 1 0.0166 0.0587 0.3298
Leishmania major hypothetical protein, conserved 0.0025 0.004 0.022
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0143 0.0784
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.002 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0188 0.0706
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.002 0.0087
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0074 0.0229 0.0695
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0024 0.0036 0.0032
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0064 0.0189 0.0558
Wolbachia endosymbiont of Brugia malayi fructose-1,6-bisphosphatase 0.0038 0.0088 0.021
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0188 0.0706
Schistosoma mansoni smad 0.0024 0.0036 0.0135
Brugia malayi intermediate filament protein 0.0028 0.0051 0.0263
Loa Loa (eye worm) jmjC domain-containing protein 0.004 0.0098 0.0397
Mycobacterium tuberculosis Conserved protein 0.0074 0.0229 0.0695
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0057 0.0163 0.0429
Loa Loa (eye worm) hypothetical protein 0.0187 0.0668 0.281
Echinococcus granulosus survival motor neuron protein 1 0.0247 0.0903 0.3383
Brugia malayi G-protein alpha subunit 0.002 0.002 0.0087
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.008 0.0253 0.0739
Leishmania major oxidoreductase-like protein 0.0052 0.0143 0.2094
Loa Loa (eye worm) histone methyltransferase 0.003 0.0058 0.0227
Brugia malayi MH2 domain containing protein 0.0024 0.0036 0.0179
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0057 0.0163 0.4399
Onchocerca volvulus Alhambra homolog 0.0029 0.0054 0.0189
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Echinococcus multilocularis smad 0.0024 0.0036 0.0032
Schistosoma mansoni Smad4 0.0024 0.0036 0.0135
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0065
Leishmania major acetyl-CoA carboxylase, putative 0.0164 0.0579 1
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0088 0.0236
Loa Loa (eye worm) MH2 domain-containing protein 0.0024 0.0036 0.0134
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.047 0.1771 1
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0051 0.0141 0.0579
Trypanosoma brucei serine peptidase, Clan SC, Family S9B 0.0057 0.0164 0.247
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0098 0.0369
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Schistosoma mansoni pyruvate carboxylase 0.0062 0.0184 0.0692
Loa Loa (eye worm) hypothetical protein 0.0064 0.0189 0.0782
Trypanosoma cruzi myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0088 0.197
Brugia malayi Guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.002 0.0087
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0064 0.0189 0.071
Echinococcus multilocularis expressed protein 0.002 0.002 0.0015
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0043 0.0108 0.044
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0043 0.0108 0.2619
Toxoplasma gondii acetyl-CoA carboxylase ACC1 0.0164 0.0579 0.1905
Leishmania major importin beta-1 subunit, putative 0.0047 0.0125 0.1773
Leishmania major dipeptidyl-peptidase 8-like serine peptidase, putative,serine peptidase, Clan SC, Family S9B 0.0057 0.0164 0.247
Echinococcus granulosus propionyl coenzyme A carboxylase beta chain 0.0022 0.0027 0.0087
Schistosoma mansoni inositol monophosphatase 0.0038 0.0088 0.0332
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.003 0.0058 0.0054
Onchocerca volvulus Huntingtin homolog 0.0128 0.0439 0.2286
Mycobacterium ulcerans enoyl-(acyl carrier protein) reductase 0.0765 0.2922 1
Schistosoma mansoni GTP-binding protein (q) alpha-11 subunit gna11 0.002 0.002 0.0074
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0052 0.0145 0.0407
Mycobacterium tuberculosis Probable pyruvate carboxylase Pca (pyruvic carboxylase) 0.0062 0.0184 0.0541
Loa Loa (eye worm) intermediate filament protein 0.0028 0.0051 0.0196
Brugia malayi prolyl oligopeptidase family protein 0.0057 0.0164 0.0902
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0028 0.0048 0.0072
Leishmania major pteridine reductase 1 0.0052 0.0143 0.2094
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.002 0.0074
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0188 0.0706
Schistosoma mansoni intermediate filament proteins 0.0028 0.0051 0.0191
Echinococcus granulosus guanine nucleotide binding protein G protein 0.002 0.002 0.0058
Echinococcus multilocularis gtp binding protein (I) alpha 1subunit 0.002 0.002 0.0015
Brugia malayi hypothetical protein 0.0128 0.0439 0.2463
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0143 0.0399
Mycobacterium ulcerans esterase/lipase LipP 0.0074 0.0229 0.0695
Loa Loa (eye worm) GTP-binding regulatory protein alpha chain 0.002 0.002 0.0065
Schistosoma mansoni propionyl-CoA carboxylase beta chain mitochondrial precursor 0.0022 0.0027 0.0103
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.002 0.0074
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0472 0.1779 0.605
Mycobacterium ulcerans bifunctional protein acetyl-/propionyl-coenzyme a carboxylase (alpha chain) AccA3 0.0062 0.0184 0.0541
Mycobacterium ulcerans extragenic suppressor protein SuhB 0.0038 0.0088 0.021
Echinococcus multilocularis lamin 0.0028 0.0051 0.0046
Brugia malayi latrophilin 2 splice variant baaae 0.0035 0.0078 0.0416
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0024 0.0036 0.0135
Trypanosoma brucei importin beta-1 subunit, putative 0.0058 0.0168 0.2553
Loa Loa (eye worm) 3-hydroxyacyl-CoA dehydrogenase type II 0.0052 0.0143 0.0587
Mycobacterium ulcerans lipase LipD 0.0074 0.0229 0.0695
Schistosoma mansoni lamin 0.0028 0.0051 0.0191
Plasmodium vivax hypothetical protein, conserved 0.0074 0.0229 0.0656
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0028 0.0048 0.0031
Brugia malayi Smad1 0.0024 0.0036 0.0179
Brugia malayi jmjC domain containing protein 0.004 0.0098 0.0531
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0057 0.0163 0.2461
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.0002
Trichomonas vaginalis set domain proteins, putative 0.0492 0.1855 0.6325
Toxoplasma gondii thioredoxin reductase 0.0038 0.009 0.0216
Plasmodium falciparum phd finger protein, putative 0.0029 0.0054 0.0051
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0163 0.0494
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.047 0.1771 0.6657
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain AccA1 0.0062 0.0184 0.0541
Toxoplasma gondii inositol(myo)-1(or 4)-monophosphatase 2, putative 0.0038 0.0088 0.021
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Mycobacterium tuberculosis Probable dehydrogenase/reductase 0.0052 0.0143 0.0399
Loa Loa (eye worm) jmjC domain-containing protein 0.006 0.0175 0.0723
Mycobacterium tuberculosis Probable esterase LipL 0.0074 0.0229 0.0695
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0057 0.0163 0.0672
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Toxoplasma gondii ABC1 family protein 0.0074 0.0229 0.0695
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0739
Giardia lamblia PHD finger protein 15 0.0029 0.0054 0.0405
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Echinococcus multilocularis lamin dm0 0.0028 0.0051 0.0046
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Onchocerca volvulus 0.0074 0.0229 0.1139
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0057 0.0163 0.0159
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Loa Loa (eye worm) transcription factor SMAD2 0.0358 0.1334 0.5631
Mycobacterium ulcerans hypothetical protein 0.0074 0.0229 0.0695
Loa Loa (eye worm) hypothetical protein 0.0247 0.0903 0.3805
Trichomonas vaginalis importin beta-1, putative 0.0047 0.0125 0.0364
Trypanosoma brucei beta-ketoacyl-ACP reductase 0.0052 0.0143 0.2094
Loa Loa (eye worm) hypothetical protein 0.0051 0.0141 0.0579
Onchocerca volvulus 0.009 0.029 0.1474
Wolbachia endosymbiont of Brugia malayi Short-chain alcohol dehydrogenase family enzyme 0.0052 0.0143 0.0399
Trichomonas vaginalis esterase, putative 0.0074 0.0229 0.072
Mycobacterium tuberculosis Conserved protein 0.0074 0.0229 0.0695
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.047 0.1771 0.6657
Onchocerca volvulus 0.0052 0.0143 0.0672
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0125 0.0364
Trypanosoma brucei 3-methylcrotonyl-CoA carboxylase alpha subunit, putative 0.0062 0.0184 0.2839
Loa Loa (eye worm) TAR-binding protein 0.0063 0.0188 0.0777
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0064 0.0189 0.0185
Echinococcus granulosus lamin dm0 0.0028 0.0051 0.0175
Brugia malayi Intermediate filament tail domain containing protein 0.0028 0.0051 0.0263
Onchocerca volvulus 0.0074 0.0229 0.1139
Echinococcus granulosus jumonji domain containing protein 0.0041 0.0099 0.0356
Mycobacterium tuberculosis Probable oxidoreductase 0.0097 0.0319 0.1007
Loa Loa (eye worm) RNA binding protein 0.0063 0.0188 0.0777
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0043 0.0108 0.0279
Trypanosoma cruzi acetyl-CoA carboxylase 0.0101 0.0336 1
Brugia malayi hypothetical protein 0.0016 0.0005 0.0002
Leishmania major myo-inositol-1(or 4)-monophosphatase 1, putative 0.0038 0.0088 0.1102
Plasmodium falciparum thioredoxin reductase 0.0038 0.009 0.0175
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Schistosoma mansoni hypothetical protein 0.0698 0.266 1
Echinococcus granulosus lamin 0.0028 0.0051 0.0175
Toxoplasma gondii aldehyde dehydrogenase 0.0059 0.017 0.0493
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0028 0.0048 0.0031
Echinococcus granulosus propionyl coenzyme A carboxylase alpha chain 0.0062 0.0184 0.0676
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.008 0.0253 0.0778
Schistosoma mansoni importin beta-1 0.0058 0.0168 0.0632
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0229 0.072
Echinococcus multilocularis importin subunit beta 1 0.0058 0.0168 0.0164
Echinococcus granulosus beta LACTamase domain containing family member 0.0074 0.0229 0.0845
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0087 0.0281 0.0876
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0029 0.0054 0.0205
Loa Loa (eye worm) oxidoreductase 0.0052 0.0143 0.0587
Onchocerca volvulus 0.0028 0.0051 0.0169
Entamoeba histolytica 3-oxoacyl-(acyl-carrier protein) reductase, putative 0.0052 0.0143 0.8593
Schistosoma mansoni cpg binding protein 0.0095 0.031 0.1166
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-6 subunit 0.002 0.002 0.0065
Mycobacterium tuberculosis Probable lipase LipD 0.0074 0.0229 0.0695
Schistosoma mansoni GTP-binding protein (I) alpha-2 subunit gnai2 0.002 0.002 0.0074
Brugia malayi RNA binding protein 0.0063 0.0188 0.1039
Schistosoma mansoni acetyl-CoA carboxylase 0.0164 0.0579 0.2176
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Echinococcus granulosus inositol monophosphatase 1 0.0038 0.0088 0.0316
Brugia malayi guanine nucleotide-binding protein alpha-3 subunit, putative 0.002 0.002 0.0087
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0393
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0043 0.0108 0.0238
Brugia malayi Bromodomain containing protein 0.0029 0.0054 0.0283
Loa Loa (eye worm) hypothetical protein 0.0029 0.0054 0.0212
Toxoplasma gondii enoyl-acyl carrier reductase ENR 0.0765 0.2922 1
Echinococcus granulosus TGF beta signal transducer SmadC 0.0024 0.0036 0.0119
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.017 0.0493
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0778
Plasmodium falciparum biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0118 0.0403 0.1259
Brugia malayi F/Y-rich N-terminus family protein 0.0039 0.0094 0.0505
Echinococcus granulosus dipeptidyl aminopeptidaseprotein 0.017 0.0603 0.2255
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0043 0.0108 0.1465
Schistosoma mansoni hypothetical protein 0.0623 0.2366 0.8894
Schistosoma mansoni cpg binding protein 0.009 0.029 0.1091
Brugia malayi hypothetical protein 0.0044 0.0111 0.0605
Echinococcus granulosus guanine nucleotide binding protein subunit 0.002 0.002 0.0058
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Entamoeba histolytica myo-inositol monophosphatase, putative 0.0038 0.0088 0.478
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0016
Schistosoma mansoni ran 0.0043 0.0108 0.0407
Brugia malayi Thioredoxin reductase 0.0038 0.009 0.0485
Brugia malayi hypothetical protein 0.002 0.002 0.0087
Echinococcus granulosus Dipeptidyl peptidase 9 0.0057 0.0164 0.06
Trichomonas vaginalis myo inositol monophosphatase, putative 0.0038 0.0088 0.0236
Trypanosoma brucei pteridine reductase 1 0.0052 0.0143 0.2094
Schistosoma mansoni GTP-binding protein alpha subunit gna 0.002 0.002 0.0074
Mycobacterium leprae Probable lipase LipE 0.0074 0.0229 0.0695
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.047 0.1771 0.1767
Leishmania major methylcrotonoyl-coa carboxylase biotinylated subunitprotein-like protein 0.0062 0.0184 0.2839
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0097 0.0319 0.1007
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] reductase, putative 0.0052 0.0143 0.0359
Schistosoma mansoni hypothetical protein 0.0035 0.0078 0.0293
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0087 0.0281 0.0876
Brugia malayi guanine nucleotide-binding protein G-o protein alpha subunit 0.002 0.002 0.0087
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0097 0.0319 0.1007
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.005 0.0137 0.0752
Brugia malayi GTP-binding regulatory protein alpha chain - starfish, putative 0.002 0.002 0.0087
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0043 0.0108 0.0588
Echinococcus granulosus histone lysine N methyltransferase MLL3 0.0025 0.0037 0.0122
Mycobacterium tuberculosis Possible 20-beta-hydroxysteroid dehydrogenase FabG3 (cortisone reductase) ((R)-20-hydroxysteroid dehydrogenase) 0.0052 0.0143 0.0399
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.002 0.0074
Mycobacterium tuberculosis Probable lipase LipE 0.0074 0.0229 0.0695
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0074 0.0229 0.127
Mycobacterium ulcerans acetyl-/propionyl-coenzyme a carboxylase alpha chain, AccA2 0.0062 0.0184 0.0541
Trypanosoma cruzi PAB1-binding protein , putative 0.0025 0.004 0.0393
Echinococcus multilocularis thioredoxin glutathione reductase 0.0039 0.0092 0.0088
Toxoplasma gondii exonuclease III APE 0.0057 0.0163 0.0469
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.002 0.0015
Loa Loa (eye worm) hypothetical protein 0.0128 0.0439 0.1842
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0059 0.017 0.259
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0062 0.0184 0.0692
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0192 0.0691 0.2596
Trichomonas vaginalis ap endonuclease, putative 0.0057 0.0163 0.0494
Schistosoma mansoni dihydropteridine reductase 0.0052 0.0143 0.0537
Echinococcus multilocularis Smad4 0.0024 0.0036 0.0032
Schistosoma mansoni GTP-binding protein alpha subunit 0.002 0.002 0.0074
Mycobacterium leprae conserved hypothetical protein 0.0074 0.0229 0.0695
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Schistosoma mansoni inositol monophosphatase 0.0038 0.0088 0.0332
Echinococcus multilocularis 3 oxoacyl acyl carrier protein reductase 0.0052 0.0143 0.0139
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0052 0.0145 0.0407
Echinococcus multilocularis survival motor neuron protein 1 0.0247 0.0903 0.0899
Trypanosoma cruzi importin beta-1 subunit, putative 0.0047 0.0125 0.317
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0043 0.0108 0.5156
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Trypanosoma cruzi dipeptidyl-peptidase 8-like serine peptidase 0.0057 0.0164 0.4416
Echinococcus multilocularis peptidase Clp (S14 family) 0.0052 0.0145 0.0141
Loa Loa (eye worm) hypothetical protein 0.0044 0.0111 0.0452
Mycobacterium tuberculosis Probable reductase 0.0087 0.0281 0.0876
Trypanosoma cruzi serine peptidase, Clan SC, Family S9B 0.0057 0.0164 0.4416
Plasmodium falciparum glutathione reductase 0.0038 0.009 0.0175
Toxoplasma gondii dipeptidyl peptidase iv (dpp iv) n-terminal region domain-containing protein 0.0057 0.0164 0.047
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Loa Loa (eye worm) heterotrimeric G protein alpha subunit 0.002 0.002 0.0065
Leishmania major GTP-binding protein, putative 0.0043 0.0108 0.1465
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0016
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0059 0.017 0.0493
Echinococcus multilocularis geminin 0.0698 0.266 0.2657
Onchocerca volvulus 0.0492 0.1855 1
Trichomonas vaginalis helicase, putative 0.002 0.002 0.0002
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0028 0.0051 0.0196
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0047 0.0125 0.0364
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0229 0.086
Loa Loa (eye worm) hypothetical protein 0.0028 0.0051 0.0196
Brugia malayi Voltage-gated calcium channel, T-type, alpha subunit. C. elegans cca-1 ortholog 0.0187 0.0668 0.3757
Loa Loa (eye worm) inositol-1 0.0038 0.0088 0.0355
Echinococcus granulosus tar DNA binding protein 0.0063 0.0188 0.0691
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0623 0.2366 1
Loa Loa (eye worm) PHD-finger family protein 0.0029 0.0054 0.0212
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.008 0.0253 0.0248
Trichomonas vaginalis chromodomain helicase DNA binding protein, putative 0.002 0.002 0.0002
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0097 0.0319 0.1007
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0057 0.0163 0.2461
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0064 0.0189 0.0185
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0087 0.0281 0.0876
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Plasmodium vivax biotin carboxylase subunit of acetyl CoA carboxylase, putative 0.0118 0.0403 0.1259
Toxoplasma gondii histone lysine methyltransferase SET1 0.0172 0.0612 0.2018
Schistosoma mansoni jumonji/arid domain-containing protein 0.004 0.0098 0.0369
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.008 0.0253 0.0935
Mycobacterium tuberculosis Inositol-1-monophosphatase SuhB 0.0034 0.0073 0.0157
Echinococcus multilocularis peregrin 0.0029 0.0054 0.005
Mycobacterium tuberculosis Possible oxidoreductase 0.0052 0.0143 0.0399
Mycobacterium tuberculosis Probable dehydrogenase 0.0087 0.0281 0.0876
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.0057 0.0163 1
Plasmodium vivax importin-beta 2, putative 0.0058 0.0168 0.0446
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Schistosoma mansoni ran 0.0043 0.0108 0.0407
Echinococcus granulosus 3 oxoacyl acyl carrier protein reductase 0.0052 0.0143 0.0522
Mycobacterium tuberculosis Probable oxidoreductase 0.0052 0.0143 0.0399
Brugia malayi glutathione reductase 0.0038 0.009 0.0485
Toxoplasma gondii 3-ketoacyl-(acyl-carrier-protein) reductase 0.0052 0.0143 0.0399
Echinococcus granulosus intermediate filament protein 0.0028 0.0051 0.0175
Loa Loa (eye worm) hypothetical protein 0.002 0.002 0.0065
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0095 0.0312 0.1159
Trichomonas vaginalis conserved hypothetical protein 0.002 0.002 0.0002
Loa Loa (eye worm) glutathione reductase 0.0038 0.009 0.0363
Loa Loa (eye worm) retinol dehydrogenase 12 0.0052 0.0143 0.0587
Schistosoma mansoni GTP-binding protein (I) alpha subunit gnai 0.002 0.002 0.0074
Onchocerca volvulus Huntingtin homolog 0.0128 0.0439 0.2286
Trypanosoma cruzi oxidoreductase-like protein, putative 0.0052 0.0143 0.3744
Echinococcus multilocularis lysine specific demethylase 5A 0.0035 0.0078 0.0074
Toxoplasma gondii HEAT repeat-containing protein 0.0058 0.0168 0.0486
Echinococcus multilocularis guanine nucleotide binding protein (G protein) 0.002 0.002 0.0015
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0143 0.0399
Brugia malayi Probable ClpP-like protease 0.008 0.0253 0.1406
Schistosoma mansoni GTP-binding protein (I) alpha-1subunit gnai1 0.002 0.002 0.0074
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0087 0.0281 0.0876
Trypanosoma brucei hypothetical protein, conserved 0.0074 0.0229 0.365
Leishmania major carboxylase, putative 0.0062 0.0184 0.2839
Mycobacterium ulcerans 3-oxoacyl-ACP reductase 0.0052 0.0143 0.0399
Echinococcus granulosus PHD finger protein rhinoceros 0.0029 0.0054 0.0188
Chlamydia trachomatis enoyl-acyl-carrier protein reductase 0.0765 0.2922 1
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0059 0.017 0.0625
Mycobacterium leprae 3-OXOACYL-[ACYL-CARRIER PROTEIN] REDUCTASE FABG1 (3-KETOACYL-ACYL CARRIER PROTEIN REDUCTASE) (MYCOLIC ACID BIOSYNTHESIS A PROTEI 0.0052 0.0143 0.0399
Onchocerca volvulus 0.0064 0.0189 0.0922
Brugia malayi beta-lactamase family protein 0.0074 0.0229 0.127
Onchocerca volvulus Dipeptidyl peptidase family member 1 homolog 0.017 0.0603 0.3179
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0179
Echinococcus granulosus lysine specific demethylase 5A 0.004 0.0098 0.0353
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0074 0.0229 0.0695
Echinococcus granulosus mixed lineage leukemia protein mll 0.0025 0.0037 0.0122
Echinococcus granulosus snurportin 1 0.0623 0.2366 0.8892
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.008 0.0253 0.0778
Schistosoma mansoni aldehyde dehydrogenase 0.0059 0.017 0.064
Mycobacterium ulcerans 3-alpha-hydroxysteroid dehydrogenase 0.0052 0.0143 0.0399
Entamoeba histolytica acetyl-coA carboxylase, putative 0.0028 0.005 0.2102
Loa Loa (eye worm) hypothetical protein 0.008 0.0253 0.1051
Loa Loa (eye worm) hypothetical protein 0.0035 0.0078 0.0311
Schistosoma mansoni hypothetical protein 0.005 0.0137 0.0516
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.047 0.1771 0.6651
Plasmodium falciparum importin beta, putative 0.0058 0.0168 0.0446
Loa Loa (eye worm) hypothetical protein 0.0025 0.004 0.0149
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0059 0.017 0.0166
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0229 0.072
Echinococcus multilocularis dipeptidyl aminopeptidaseprotein 0.017 0.0603 0.0599
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0051 0.0141 0.0774
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0087 0.0281 0.0876
Plasmodium vivax SET domain protein, putative 0.0064 0.0189 0.0518
Schistosoma mansoni hypothetical protein 0.0016 0.0004 0.0016
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0059 0.0173 0.0633
Trichomonas vaginalis inositol monophosphatase, putative 0.0038 0.0088 0.0236
Echinococcus multilocularis cpg binding protein 0.0095 0.031 0.0306
Brugia malayi guanine nucleotide-binding protein G(o), alpha subunit, putative 0.002 0.002 0.0087
Schistosoma mansoni methylcrotonyl-CoA carboxylase 0.0062 0.0184 0.0692
Loa Loa (eye worm) G protein alpha subunit 3 0.002 0.002 0.0065
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0143 0.0399
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0057 0.0163 0.0469
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.047 0.1771 0.748
Leishmania major trypanothione reductase 0.0038 0.009 0.1136
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Echinococcus multilocularis mothers against decapentaplegic 5 0.0024 0.0036 0.0032
Loa Loa (eye worm) MH1 domain-containing protein 0.0024 0.0036 0.0134
Brugia malayi TAR-binding protein 0.0063 0.0188 0.1039
Loa Loa (eye worm) guanine nucleotide-binding protein alpha-12 subunit 0.002 0.002 0.0065
Trichomonas vaginalis penicillin-binding protein, putative 0.0074 0.0229 0.072
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0188 0.0706
Loa Loa (eye worm) MH2 domain-containing protein 0.0358 0.1334 0.5631
Echinococcus multilocularis histone lysine N methyltransferase MLL3 0.0025 0.0037 0.0032
Loa Loa (eye worm) hypothetical protein 0.0074 0.0229 0.095
Schistosoma mansoni lamin 0.0028 0.0051 0.0191
Mycobacterium tuberculosis Probable hydrolase 0.0074 0.0229 0.0695
Schistosoma mansoni cpg binding protein 0.0095 0.031 0.1166
Plasmodium vivax glutathione reductase, putative 0.0038 0.009 0.0175
Trypanosoma brucei unspecified product 0.0041 0.0101 0.1329
Toxoplasma gondii PHD-finger domain-containing protein 0.0029 0.0054 0.0093
Schistosoma mansoni smad1 5 8 and 0.0024 0.0036 0.0135
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0432 0.1624 0.6858
Loa Loa (eye worm) beta-lactamase 0.0074 0.0229 0.095
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0074 0.0229 0.086
Mycobacterium ulcerans short chain dehydrogenase 0.0052 0.0143 0.0399
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0057 0.0163 0.0469
Onchocerca volvulus 0.005 0.0137 0.0641
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0052 0.0143 0.0784
Echinococcus multilocularis propionyl coenzyme A carboxylase alpha chain 0.0062 0.0184 0.018
Mycobacterium tuberculosis Probable short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Brugia malayi exodeoxyribonuclease III family protein 0.0057 0.0163 0.0899
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Mycobacterium ulcerans beta-lactamase 0.0074 0.0229 0.0695
Brugia malayi Inositol-1 0.0038 0.0088 0.0475
Trichomonas vaginalis D-aminoacylase, putative 0.0074 0.0229 0.072
Plasmodium falciparum enoyl-acyl carrier reductase 0.0765 0.2922 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0059 0.017 0.0493
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0057 0.0163 0.4399
Toxoplasma gondii short chain dehydrogenase family protein, putative 0.0052 0.0143 0.0399
Trichomonas vaginalis chromodomain-helicase-DNA-binding protein, putative 0.002 0.002 0.0002
Schistosoma mansoni ap endonuclease 0.0057 0.0163 0.0613
Trypanosoma cruzi beta-ketoacyl-ACP reductase 0.0052 0.0143 0.3744
Brugia malayi MH2 domain containing protein 0.0024 0.0036 0.0179
Echinococcus multilocularis propionyl coenzyme A carboxylase beta chain 0.0022 0.0027 0.0023
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.047 0.1771 0.1767
Echinococcus granulosus histone lysine methyltransferase setb 0.0064 0.0189 0.0695
Schistosoma mansoni hypothetical protein 0.0698 0.266 1
Loa Loa (eye worm) hypothetical protein 0.0028 0.0049 0.0188
Echinococcus granulosus cpg binding protein 0.0095 0.031 0.1152
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0064 0.0189 0.071
Trypanosoma cruzi 3-methylcrotonyl-CoA carboxylase, putative 0.0062 0.0184 0.5074
Echinococcus multilocularis snurportin 1 0.0623 0.2366 0.2363
Toxoplasma gondii acetyl-coA carboxylase ACC2 0.0164 0.0579 0.1905
Wolbachia endosymbiont of Brugia malayi Acetyl/propionyl-CoA carboxylase, alpha subunit 0.0062 0.0184 0.0541
Plasmodium vivax enoyl-acyl carrier protein reductase 0.0765 0.2922 1
Brugia malayi jmjC domain containing protein 0.0095 0.0312 0.1743
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 0.0778
Echinococcus granulosus peregrin 0.0029 0.0054 0.0188
Echinococcus multilocularis musashi 0.0028 0.0051 0.0046
Brugia malayi Pre-SET motif family protein 0.0064 0.0189 0.1045
Mycobacterium leprae possible inositol monophosphatase SubH (IMPase) (inositol-1-phosphatase) (I-1-Pase ). 0.0034 0.0073 0.0157
Loa Loa (eye worm) hypothetical protein 0.0058 0.0168 0.0694
Brugia malayi guanine nucleotide-binding protein alpha-7 subunit, putative 0.002 0.002 0.0087
Brugia malayi CXXC zinc finger family protein 0.009 0.029 0.1619
Loa Loa (eye worm) hypothetical protein 0.0128 0.0439 0.1842
Toxoplasma gondii 2,4-dienoyl CoA reductase 2, peroxisomal family protein 0.0052 0.0143 0.0399
Loa Loa (eye worm) CXXC zinc finger family protein 0.009 0.029 0.1211
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0074 0.0229 0.095
Echinococcus multilocularis inositol monophosphatase 1 0.0038 0.0088 0.0084
Echinococcus multilocularis guanine nucleotide binding protein subunit 0.002 0.002 0.0015
Brugia malayi RNA recognition motif domain containing protein 0.0063 0.0188 0.1039
Mycobacterium ulcerans 3-ketoacyl-ACP reductase 0.0052 0.0143 0.0399
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.008 0.0253 1
Plasmodium vivax thioredoxin reductase, putative 0.0038 0.009 0.0175
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 0.0188 0.0777
Trichomonas vaginalis hypothetical protein 0.0765 0.2922 1
Mycobacterium ulcerans short-chain type dehydrogenase/reductase 0.0052 0.0143 0.0399
Echinococcus granulosus mothers against decapentaplegic 5 0.0024 0.0036 0.0119
Loa Loa (eye worm) Smad1 0.0024 0.0036 0.0134
Schistosoma mansoni tar DNA-binding protein 0.0063 0.0188 0.0706
Brugia malayi MH1 domain containing protein 0.0024 0.0036 0.0179

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 40.56 % Analgesic activity in ICR mouse assessed as pain threshold variation at 0.13 mmol/kg, ip after 150 mins by tail flick test ChEMBL. 17804120
Activity (functional) = 47.57 % Analgesic activity in ICR mouse assessed as pain threshold variation at 0.13 mmol/kg, ip after 30 mins by tail flick test relative to control ChEMBL. 17804120
Activity (functional) = 52.21 % Analgesic activity in ICR mouse assessed as pain threshold variation at 0.13 mmol/kg, ip after 120 mins by tail flick test ChEMBL. 17804120
Activity (functional) = 60.65 % Analgesic activity in ICR mouse assessed as pain threshold variation at 0.13 mmol/kg, ip after 90 mins by tail flick test relative to control ChEMBL. 17804120
Activity (functional) = 61.52 % Analgesic activity in ICR mouse assessed as pain threshold variation at 0.13 mmol/kg, ip after 60 mins by tail flick test relative to control ChEMBL. 17804120
Activity (ADMET) = 116.8 % Thrombotic toxicity in ICR mouse assessed as tail bleeding time at 1.3 mmol/kg, ip after 60 mins ChEMBL. 17804120
Activity (ADMET) = 118.2 % Thrombotic toxicity in ICR mouse assessed as tail bleeding time at 1.3 mmol/kg, ip after 15 mins ChEMBL. 17804120
Activity (ADMET) = 119.2 % Thrombotic toxicity in ICR mouse assessed as tail bleeding time at 1.3 mmol/kg, ip after 30 mins ChEMBL. 17804120
Activity (ADMET) = 119.2 % Thrombotic toxicity in ICR mouse assessed as tail bleeding time at 1.3 mmol/kg, ip after 5 mins ChEMBL. 17804120

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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