Detailed information for compound 100855

Basic information

Technical information
  • TDR Targets ID: 100855
  • Name: 1-[5-tert-butyl-2-(3-methoxyphenyl)pyrazol-3- yl]-3-(2,3-dichlorophenyl)urea
  • MW: 433.331 | Formula: C21H22Cl2N4O2
  • H donors: 2 H acceptors: 2 LogP: 5.72 Rotable bonds: 7
    Rule of 5 violations (Lipinski): 1
  • SMILES: COc1cccc(c1)n1nc(cc1NC(=O)Nc1cccc(c1Cl)Cl)C(C)(C)C
  • InChi: 1S/C21H22Cl2N4O2/c1-21(2,3)17-12-18(27(26-17)13-7-5-8-14(11-13)29-4)25-20(28)24-16-10-6-9-15(22)19(16)23/h5-12H,1-4H3,(H2,24,25,28)
  • InChiKey: PRKGLTOOEULMFS-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

  • 1-[5-tert-butyl-2-(3-methoxyphenyl)-3-pyrazolyl]-3-(2,3-dichlorophenyl)urea

Targets

Known targets for this compound

Species Target name Source Bibliographic reference
Homo sapiens mitogen-activated protein kinase 14 Starlite/ChEMBL References

Predicted pathogen targets for this compound

By orthology
Species Potential target Known druggable target/s Ortholog Group
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania braziliensis mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania mexicana mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania donovani mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma cruzi mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus granulosus mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei gambiense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania infantum mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma congolense mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 14 Get druggable targets OG5_128610 All targets in OG5_128610
Candida albicans MAP kinase involved in osmoregulation Get druggable targets OG5_128610 All targets in OG5_128610
Brugia malayi P38 map kinase family protein 2 Get druggable targets OG5_128610 All targets in OG5_128610
Trypanosoma brucei mitogen-activated protein kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative Get druggable targets OG5_128610 All targets in OG5_128610
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase Get druggable targets OG5_128610 All targets in OG5_128610
Schistosoma japonicum ko:K04441 p38 MAP kinase, putative Get druggable targets OG5_128610 All targets in OG5_128610
Echinococcus multilocularis mitogen activated protein kinase 11 Get druggable targets OG5_128610 All targets in OG5_128610
By sequence similarity to non orthologous known druggable targets
Species Potential target Known druggable target Length Alignment span Identity
Trypanosoma brucei mitogen-activated protein kinase 5 mitogen-activated protein kinase 14 360 aa 336 aa 33.3 %
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0043 0.0222 0.0222
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0023 0.0038 0.017
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0049 0.0279 0.1131
Loa Loa (eye worm) steroid hormone receptor 0.0081 0.0578 0.0534
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0428 0.3797 0.4531
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Plasmodium falciparum glutathione reductase 0.0065 0.0426 0.0217
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0049 0.0279 0.1131
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0179 0.0077
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0039 0.0186 0.0488
Trichomonas vaginalis ferritin, putative 0.0123 0.0964 1
Schistosoma mansoni RAR-like nuclear receptor 0.0081 0.0578 0.0578
Entamoeba histolytica hypothetical protein 0.0311 0.2713 1
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0123 0.0964 0.0782
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0004
Echinococcus multilocularis expressed protein 0.0032 0.0123 0.0021
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Echinococcus multilocularis Smad4 0.0068 0.0449 0.035
Toxoplasma gondii NADPH-glutathione reductase 0.0065 0.0426 0.0432
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0578 0.0534
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0428 0.3797 0.552
Echinococcus multilocularis lamin dm0 0.0082 0.0582 0.0485
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0892 0.9193
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0081 0.0578 0.0534
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.026 0.2238 0.2395
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0081 0.0578 0.0481
Loa Loa (eye worm) hypothetical protein 0.004 0.0189 0.0097
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Brugia malayi beta-lactamase 0.0115 0.0892 0.0886
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0129 0.0672
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0578 0.0481
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Echinococcus multilocularis expressed protein 0.0123 0.0964 0.0871
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0081 0.0578 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0186 0.1309
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0048 0.0266 0.0183
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0065 0.0426 0.0363
Trichomonas vaginalis rotamase, putative 0.0032 0.0123 0.0603
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0049 0.0273 0.0173
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0049 0.0279 0.1131
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0081 0.0578 0.0534
Schistosoma mansoni ferritin 0.0123 0.0964 0.0964
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0065 0.0426 0.2666
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0273 0.109
Brugia malayi P38 map kinase family protein 2 0.0152 0.1234 0.1269
Brugia malayi Fli-1 protein 0.0225 0.1914 0.2032
Trichomonas vaginalis glutathione reductase, putative 0.0065 0.0426 0.399
Brugia malayi photoreceptor-specific nuclear receptor 0.0081 0.0578 0.0534
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Mycobacterium tuberculosis Conserved protein 0.0115 0.0892 0.0969
Echinococcus multilocularis tar DNA binding protein 0.026 0.2238 0.2158
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0043 0.0222 0.0121
Toxoplasma gondii hypothetical protein 0.0278 0.24 0.3178
Schistosoma mansoni ferritin light chain 0.0123 0.0964 0.0964
Brugia malayi MH1 domain containing protein 0.0068 0.0449 0.0389
Brugia malayi MH2 domain containing protein 0.0068 0.0449 0.0389
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0102 0.077 0.0749
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Echinococcus granulosus thyroid hormone receptor alpha 0.0038 0.0179 0.0084
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0428 0.3797 0.552
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0093 0.0268
Trichomonas vaginalis esterase, putative 0.0115 0.0892 0.9193
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0892 0.9193
Schistosoma mansoni tar DNA-binding protein 0.026 0.2238 0.2238
Brugia malayi latrophilin 2 splice variant baaae 0.007 0.047 0.0412
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0049 0.0279 0.0179
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0426 0.2666
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.0082
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0081 0.0578 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0186 0.1309
Mycobacterium ulcerans hypothetical protein 0.0115 0.0892 0.0677
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0578 0.0521
Mycobacterium tuberculosis Probable reductase 0.0428 0.3797 0.552
Schistosoma mansoni hypothetical protein 0.1015 0.9244 0.9244
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0081 0.0578 0.0534
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0476 0.4241 0.6215
Onchocerca volvulus 0.0081 0.0578 0.6031
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0048 0.0266 0.0183
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Loa Loa (eye worm) hypothetical protein 0.0102 0.077 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0032 0.0119 0.0562
Loa Loa (eye worm) hypothetical protein 0.007 0.047 0.0412
Echinococcus multilocularis mothers against decapentaplegic 5 0.0068 0.0449 0.035
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0049 0.0279 0.0631
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0273 0.109
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0081 0.0578 0.0578
Plasmodium falciparum thioredoxin reductase 0.0188 0.1565 0.1837
Onchocerca volvulus 0.0038 0.0179 0.0971
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0278 0.24 0.287
Brugia malayi ecdysteroid receptor 0.0081 0.0578 0.0534
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0279 0.2354
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0115 0.0892 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Loa Loa (eye worm) phosphatidylinositol 3 0.0049 0.0279 0.0199
Echinococcus multilocularis ferritin 0.0123 0.0964 0.0871
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0081 0.0578 0.0578
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0279 0.2354
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.0806 0.7304 0.7878
Brugia malayi nuclear receptor NHR-88 0.0081 0.0578 0.0534
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0278 0.24 0.3024
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Onchocerca volvulus 0.0082 0.0582 0.6079
Brugia malayi RNA recognition motif domain containing protein 0.026 0.2238 0.2395
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0032 0.0122 0.0022
Mycobacterium tuberculosis Probable esterase LipL 0.0115 0.0892 0.0969
Loa Loa (eye worm) nuclear receptor NHR-67 0.0038 0.0179 0.0086
Brugia malayi orphan nuclear receptor NR2E1 0.0038 0.0179 0.0086
Echinococcus multilocularis thioredoxin glutathione reductase 0.0188 0.157 0.1483
Schistosoma mansoni smad1 5 8 and 0.0068 0.0449 0.0449
Schistosoma mansoni smad1 5 8 and 0.0068 0.0449 0.0449
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Brugia malayi cytoplasmic intermediate filament protein 0.0044 0.0229 0.0143
Brugia malayi glutathione reductase 0.0188 0.1565 0.164
Mycobacterium leprae PROBABLE BACTERIOFERRITIN BFRA 0.0123 0.0964 0.0113
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0081 0.0578 0.0534
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0081 0.0578 0.0521
Schistosoma mansoni apoferritin-2 0.0123 0.0964 0.0964
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0273 0.0173
Toxoplasma gondii ABC1 family protein 0.0115 0.0892 0.108
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.004 0.0189 0.0088
Treponema pallidum bacterioferrin (TpF1) 0.0123 0.0964 0.0782
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0081 0.0578 0.0521
Schistosoma mansoni smad 0.0068 0.0449 0.0449
Echinococcus granulosus FTZ F1 alpha 0.0081 0.0578 0.0521
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0892 0.9193
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0038 0.0179 0.0086
Brugia malayi tailless protein 0.0038 0.0179 0.0086
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0082 0.0582 0.0538
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0426 0.2142
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0081 0.0578 0.0534
Loa Loa (eye worm) hypothetical protein 0.0037 0.0169 0.0075
Schistosoma mansoni hypothetical protein 0.0032 0.0122 0.0122
Giardia lamblia NADH oxidase lateral transfer candidate 0.0065 0.0426 1
Loa Loa (eye worm) MH2 domain-containing protein 0.0991 0.902 1
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0049 0.0273 0.109
Leishmania major mitogen-activated protein kinase 3, putative,map kinase 3, putative 0.0152 0.1234 0.7717
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0049 0.0273 0.0273
Onchocerca volvulus 0.0115 0.0892 1
Mycobacterium tuberculosis Conserved protein 0.0115 0.0892 0.0969
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0311 0.2713 0.2638
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.0806 0.7304 0.7276
Loa Loa (eye worm) MH1 domain-containing protein 0.0068 0.0449 0.0389
Brugia malayi nuclear hormone receptor family member odr-7 0.0038 0.0179 0.0086
Echinococcus granulosus TGF beta signal transducer SmadC 0.0068 0.0449 0.0379
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0081 0.0578 0.0578
Trypanosoma cruzi target of rapamycin kinase 3 0.0039 0.0186 0.0488
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0081 0.0578 0.0578
Plasmodium vivax glutathione reductase, putative 0.0188 0.1565 0.1837
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1234 0.1143
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0043 0.0222 0.0222
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0222 0.0134
Entamoeba histolytica hypothetical protein 0.0311 0.2713 1
Loa Loa (eye worm) TAR-binding protein 0.026 0.2238 0.2395
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0081 0.0578 0.0534
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0065 0.0426 0.0327
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0038 0.0179 0.0084
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0065 0.0426 0.0217
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0428 0.3797 0.552
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0032 0.0122 0.002
Brugia malayi Isocitrate dehydrogenase 0.0049 0.0273 0.0192
Loa Loa (eye worm) fli-1 protein 0.0225 0.1914 0.2032
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0038 0.0179 0.0179
Brugia malayi beta-lactamase family protein 0.0115 0.0892 0.0886
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0578 0.0534
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0806 0.7304 1
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Mycobacterium tuberculosis Probable lipase LipD 0.0115 0.0892 0.0969
Brugia malayi Latrophilin receptor protein 2 0.0032 0.0122 0.0022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Echinococcus granulosus ferritin 0.0123 0.0964 0.0943
Onchocerca volvulus Bile acid receptor homolog 0.0081 0.0578 0.6031
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0065 0.0426 0.2142
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0273 0.0173
Schistosoma mansoni nuclear hormone receptor 0.0081 0.0578 0.0578
Echinococcus granulosus nuclear receptor nhr 48 0.0038 0.0179 0.0084
Echinococcus granulosus GA binding protein alpha chain 0.0074 0.0511 0.0448
Brugia malayi MH2 domain containing protein 0.0068 0.0449 0.0389
Mycobacterium tuberculosis Probable lipase LipE 0.0115 0.0892 0.0969
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0179 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0081 0.0578 0.0534
Echinococcus multilocularis isocitrate dehydrogenase 0.0049 0.0273 0.0173
Schistosoma mansoni peptidase Clp (S14 family) 0.0806 0.7304 0.7304
Brugia malayi nuclear receptor NHR-88 0.0038 0.0179 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0186 0.1309
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0049 0.0273 0.1684
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0065 0.0426 0.0217
Plasmodium vivax thioredoxin reductase, putative 0.0188 0.1565 0.1837
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0049 0.0273 0.0173
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0081 0.0578 0.0534
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0806 0.7304 1
Loa Loa (eye worm) hypothetical protein 0.0043 0.0222 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0042 0.0212 0.1607
Schistosoma mansoni tar DNA-binding protein 0.026 0.2238 0.2238
Brugia malayi Nuclear hormone receptor E75 0.0038 0.0179 0.0086
Schistosoma mansoni transcription factor LCR-F1 0.0311 0.2713 0.2713
Plasmodium vivax hypothetical protein, conserved 0.0115 0.0892 0.088
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0081 0.0578 0.6031
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0095 0.0298
Echinococcus granulosus ecdysone induced protein 78C 0.0081 0.0578 0.0521
Brugia malayi Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 0.0032 0.0123 0.0023
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1234 0.1143
Schistosoma mansoni tar DNA-binding protein 0.026 0.2238 0.2238
Schistosoma mansoni thyroid hormone receptor 0.1096 1 1
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0081 0.0578 0.0481
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0179 0.0179
Brugia malayi hypothetical protein 0.0038 0.0179 0.0086
Loa Loa (eye worm) latrophilin receptor protein 2 0.0032 0.0122 0.0022
Loa Loa (eye worm) hypothetical protein 0.0043 0.0222 0.0134
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Brugia malayi Nuclear hormone receptor-like 1 0.0043 0.0222 0.0134
Brugia malayi nuclear hormone receptor family member nhr-6 0.0038 0.0179 0.0086
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0081 0.0578 0.0534
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0065 0.0426 0.2666
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0081 0.0578 0.0481
Schistosoma mansoni thyroid hormone receptor 0.1096 1 1
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0123 0.0964 0.1082
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0081 0.0578 0.0521
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0273 0.022
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0081 0.0578 0.0534
Loa Loa (eye worm) hypothetical protein 0.0043 0.0222 0.0134
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0038 0.0179 0.0077
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0892 0.0892
Schistosoma mansoni Smad4 0.003 0.0102 0.0102
Brugia malayi nuclear hormone receptor 0.0081 0.0578 0.0534
Brugia malayi MH1 domain containing protein 0.0037 0.0169 0.0075
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0065 0.0426 0.2142
Loa Loa (eye worm) hypothetical protein 0.0082 0.0582 0.0538
Schistosoma mansoni ferritin 0.0123 0.0964 0.0964
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0065 0.0426 0.0217
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0892 0.5357
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0065 0.0426 0.0239
Brugia malayi MH1 domain containing protein 0.0037 0.0169 0.0075
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0049 0.0273 0.1684
Brugia malayi Smad1 0.0068 0.0449 0.0389
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0081 0.0578 0.0534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0081 0.0578 0.0481
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0038 0.0179 0.0084
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0032 0.0122 0.0022
Echinococcus multilocularis nuclear receptor nhr 48 0.0038 0.0179 0.0077
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0081 0.0578 0.0578
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Schistosoma mansoni ferritin 0.0123 0.0964 0.0964
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0004
Mycobacterium ulcerans bacterioferritin BfrB 0.0123 0.0964 0.0782
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Echinococcus granulosus GPCR family 2 0.0032 0.0122 0.0022
Echinococcus multilocularis beta LACTamase domain containing family member 0.0115 0.0892 0.0798
Echinococcus granulosus peptidase Clp S14 family 0.0528 0.4726 0.5058
Brugia malayi nuclear receptor RXR 0.0043 0.0222 0.0134
Schistosoma mansoni tar DNA-binding protein 0.026 0.2238 0.2238
Trichomonas vaginalis mercuric reductase, putative 0.0065 0.0426 0.399
Schistosoma mansoni ets-related 0.0225 0.1914 0.1914
Onchocerca volvulus 0.0038 0.0179 0.0971
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0038 0.0179 0.0086
Loa Loa (eye worm) DR-78 0.0038 0.0179 0.0086
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0065 0.0426 0.0426
Echinococcus granulosus intermediate filament protein 0.0082 0.0582 0.0525
Schistosoma mansoni apoferritin-2 0.0123 0.0964 0.0964
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Echinococcus multilocularis FTZ F1 alpha 0.0081 0.0578 0.0481
Echinococcus multilocularis lamin 0.0082 0.0582 0.0485
Schistosoma mansoni hypothetical protein 0.0032 0.0122 0.0122
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0476 0.4241 0.6215
Mycobacterium ulcerans bacterioferritin BfrA 0.0123 0.0964 0.0782
Schistosoma mansoni lamin 0.0082 0.0582 0.0582
Toxoplasma gondii target of rapamycin (TOR), putative 0.0037 0.0162 0.0065
Echinococcus multilocularis peptidase Clp (S14 family) 0.0528 0.4726 0.4672
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0186 0.1309
Brugia malayi Ets-domain containing protein 0.0074 0.0511 0.0459
Schistosoma mansoni intermediate filament proteins 0.0082 0.0582 0.0582
Echinococcus granulosus expressed protein 0.0032 0.0123 0.0022
Schistosoma mansoni rotamase 0.0032 0.0123 0.0123
Trypanosoma cruzi trypanothione reductase, putative 0.0065 0.0426 0.2142
Echinococcus multilocularis smad 0.0068 0.0449 0.035
Echinococcus multilocularis ecdysone induced protein 78C 0.0081 0.0578 0.0481
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0102 0.077 0.0749
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0093 0.0268
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0043 0.0222 0.0131
Loa Loa (eye worm) hypothetical protein 0.0032 0.0122 0.0022
Echinococcus granulosus tar DNA binding protein 0.026 0.2238 0.2337
Echinococcus multilocularis musashi 0.0082 0.0582 0.0485
Mycobacterium tuberculosis Probable hydrolase 0.0115 0.0892 0.0969
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.1015 0.9244 0.9236
Brugia malayi intermediate filament protein 0.0082 0.0582 0.0538
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0049 0.0279 0.0199
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0095 0.0298
Brugia malayi nuclear hormone receptor 0.0038 0.0179 0.0086
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Echinococcus granulosus mitogen activated protein kinase 14 0.0152 0.1234 0.1238
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0115 0.0892 0.0886
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0065 0.0426 0.2142
Echinococcus granulosus lamin dm0 0.0082 0.0582 0.0525
Onchocerca volvulus 0.0082 0.0582 0.6079
Brugia malayi conserved hypotetical protein 0.0038 0.0179 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0578 0.0534
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0528 0.4726 0.6975
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0065 0.0426 0.0354
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0049 0.0279 0.1722
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0115 0.0892 0.0892
Trichomonas vaginalis D-aminoacylase, putative 0.0115 0.0892 0.9193
Brugia malayi MH1 domain containing protein 0.0068 0.0449 0.0389
Onchocerca volvulus 0.0115 0.0892 1
Echinococcus granulosus thioredoxin glutathione reductase 0.0188 0.157 0.1606
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0068 0.0449 0.035
Trypanosoma brucei trypanothione reductase 0.0188 0.1565 1
Brugia malayi TAR-binding protein 0.026 0.2238 0.2395
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0049 0.0279 0.0194
Toxoplasma gondii thioredoxin reductase 0.0188 0.1565 0.2016
Brugia malayi isocitrate dehydrogenase 0.0049 0.0273 0.0192
Echinococcus granulosus Smad4 0.0068 0.0449 0.0379
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0476 0.4241 0.5223
Mycobacterium tuberculosis Conserved protein 0.0115 0.0892 0.0969
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0428 0.3797 0.552
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0081 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Echinococcus granulosus expressed protein 0.0123 0.0964 0.0943
Onchocerca volvulus Protein ultraspiracle homolog 0.0081 0.0578 0.6031
Loa Loa (eye worm) D-ets-4 DNA binding domain-containing protein 0.0074 0.0511 0.0459
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Mycobacterium ulcerans lipase LipD 0.0115 0.0892 0.0677
Trichomonas vaginalis penicillin-binding protein, putative 0.0115 0.0892 0.9193
Schistosoma mansoni nuclear receptor 0.0038 0.0179 0.0179
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0068 0.0449 0.0449
Schistosoma mansoni nuclear receptor nhr-48 0.0038 0.0179 0.0179
Schistosoma mansoni ferritin light chain 0.0123 0.0964 0.0964
Trypanosoma brucei mitogen-activated protein kinase 3, putative 0.0152 0.1234 0.7869
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1234 0.7717
Loa Loa (eye worm) hypothetical protein 0.0063 0.0411 0.0347
Echinococcus granulosus beta LACTamase domain containing family member 0.0115 0.0892 0.0864
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0081 0.0578 0.0481
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0081 0.0578 0.0534
Loa Loa (eye worm) glutathione reductase 0.0188 0.1565 0.164
Loa Loa (eye worm) transcription factor SMAD2 0.0991 0.902 1
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0081 0.0578 0.0521
Brugia malayi hypothetical protein 0.0311 0.2713 0.2928
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.0806 0.7304 1
Plasmodium falciparum thioredoxin reductase 0.0065 0.0426 0.0217
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0038 0.0179 0.0077
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0065 0.0426 0.0217
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0081 0.0578 0.0521
Schistosoma mansoni coup transcription factor 0.0081 0.0578 0.0578
Loa Loa (eye worm) thioredoxin reductase 0.0188 0.1565 0.164
Loa Loa (eye worm) hypothetical protein 0.0115 0.0892 0.0886
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.0806 0.7304 1
Loa Loa (eye worm) nuclear factor I 0.0037 0.0169 0.0075
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0528 0.4726 0.598
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Brugia malayi Probable ClpP-like protease 0.0806 0.7304 0.8076
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0115 0.0892 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0004
Brugia malayi nuclear receptor RXR 0.0038 0.0179 0.0086
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0123 0.0603
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0081 0.0578 0.0534
Loa Loa (eye worm) nuclear hormone receptor 0.0038 0.0179 0.0086
Schistosoma mansoni smad 0.003 0.0102 0.0102
Loa Loa (eye worm) hypothetical protein 0.0038 0.0179 0.0086
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0115 0.0892 0.0969
Schistosoma mansoni ferritin 0.0123 0.0964 0.0964
Brugia malayi Thioredoxin reductase 0.0188 0.1565 0.164
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0049 0.0279 0.0279
Loa Loa (eye worm) CMGC/MAPK/P38 protein kinase 0.0152 0.1234 0.1269
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0065 0.0426 0.0432
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0069 0.0004
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0179 0.0971
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0081 0.0578 0.0521
Mycobacterium tuberculosis Probable oxidoreductase 0.0476 0.4241 0.6215
Loa Loa (eye worm) beta-lactamase 0.0115 0.0892 0.0886
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Mycobacterium tuberculosis Probable dehydrogenase 0.0428 0.3797 0.552
Loa Loa (eye worm) hypothetical protein 0.0043 0.0222 0.0134
Loa Loa (eye worm) RNA binding protein 0.026 0.2238 0.2395
Loa Loa (eye worm) isocitrate dehydrogenase 0.0049 0.0273 0.0192
Schistosoma mansoni lamin 0.0082 0.0582 0.0582
Trichomonas vaginalis PIKK family atypical protein kinase 0.0037 0.0162 0.1045
Trypanosoma brucei peptidyl-prolyl cis-trans isomerase/rotamase, putative 0.0032 0.0115 0.0667
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0039 0.0186 0.1122
Echinococcus multilocularis GPCR, family 2 0.0032 0.0122 0.002
Trypanosoma brucei hypothetical protein, conserved 0.0115 0.0892 0.5667
Loa Loa (eye worm) MH2 domain-containing protein 0.0068 0.0449 0.0389
Loa Loa (eye worm) hypothetical protein 0.008 0.0568 0.0523
Brugia malayi beta-lactamase family protein 0.0115 0.0892 0.0886
Trichomonas vaginalis PIKK family atypical protein kinase 0.0039 0.0186 0.1309
Trypanosoma cruzi trypanothione reductase, putative 0.0188 0.1565 1
Echinococcus granulosus lamin 0.0082 0.0582 0.0525
Schistosoma mansoni gabp alpha 0.0074 0.0511 0.0511
Loa Loa (eye worm) hypothetical protein 0.0038 0.0175 0.0082
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0179 0.0084
Echinococcus granulosus smad 0.0068 0.0449 0.0379
Schistosoma mansoni hypothetical protein 0.0311 0.2713 0.2713
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0065 0.0426 0.2666
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0032 0.0122 0.0022
Brugia malayi hypothetical protein 0.0043 0.0222 0.0134
Toxoplasma gondii isocitrate dehydrogenase 0.0049 0.0273 0.022
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0528 0.4726 0.6975
Brugia malayi ecdysone receptor 0.0038 0.0179 0.0086
Leishmania major hypothetical protein, conserved 0.0115 0.0892 0.5357
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.1015 0.9244 1
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Echinococcus granulosus cytoplasmic intermediate filament protein 0.004 0.0189 0.0095
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0065 0.0426 0.2142
Echinococcus granulosus mitogen activated protein kinase 11 0.0152 0.1234 0.1238
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0081 0.0578 0.0534
Schistosoma mansoni nuclear hormone receptor 0.0038 0.0179 0.0179
Schistosoma mansoni zinc finger protein 0.0038 0.0179 0.0179
Schistosoma mansoni hypothetical protein 0.007 0.047 0.047
Echinococcus multilocularis mitogen activated protein kinase 11 0.0152 0.1234 0.1143
Brugia malayi RNA binding protein 0.026 0.2238 0.2395
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0043 0.0222 0.0134
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0311 0.2713 0.2856
Plasmodium falciparum glutathione reductase 0.0188 0.1565 0.1837
Brugia malayi Ets-domain containing protein 0.0074 0.0511 0.0459
Loa Loa (eye worm) intermediate filament protein 0.0082 0.0582 0.0538
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0861 0.7817 0.7795
Leishmania major trypanothione reductase 0.0188 0.1565 1
Schistosoma mansoni tar DNA-binding protein 0.026 0.2238 0.2238
Echinococcus granulosus Nuclear hormone receptor HR96 0.0038 0.0179 0.0084
Brugia malayi hypothetical protein 0.0038 0.0179 0.0086
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0081 0.0578 0.0534
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0038 0.0179 0.0077
Mycobacterium ulcerans esterase/lipase LipP 0.0115 0.0892 0.0677
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0095 0.0298
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0188 0.1565 0.2023
Schistosoma mansoni retinoic acid receptor RXR 0.0081 0.0578 0.0578
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0049 0.0279 0.1131
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0123 0.0964 0.1082
Entamoeba histolytica hypothetical protein 0.0311 0.2713 1
Echinococcus multilocularis GA binding protein alpha chain 0.0074 0.0511 0.0413
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0049 0.0273 0.0187
Schistosoma mansoni hypothetical protein 0.0032 0.0122 0.0122
Loa Loa (eye worm) hypothetical protein 0.0081 0.0578 0.0534
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0278 0.24 0.2352
Brugia malayi Steroid receptor seven-up type 2 0.0081 0.0578 0.0534
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.0044 0.0229 0.0143
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0049 0.0279 0.0631
Schistosoma mansoni Smad4 0.0068 0.0449 0.0449
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0736 0.6657 1
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0049 0.0279 0.1722
Mycobacterium ulcerans beta-lactamase 0.0115 0.0892 0.0677
Echinococcus granulosus mothers against decapentaplegic 5 0.0068 0.0449 0.0379
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0038 0.0179 0.0179
Echinococcus multilocularis mitogen activated protein kinase 14 0.0152 0.1234 0.1143
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0038 0.0179 0.0971
Brugia malayi Nuclear hormone receptor-like 1 0.0081 0.0578 0.0534
Brugia malayi Calcitonin receptor-like protein seb-1 0.0102 0.077 0.0749
Brugia malayi nuclear receptor NHR-67 0.0038 0.0179 0.0086
Trypanosoma cruzi mitogen-activated protein kinase 3, putative 0.0152 0.1234 0.7717
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.0806 0.7304 1
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0032 0.0122 0.002
Brugia malayi Intermediate filament tail domain containing protein 0.0082 0.0582 0.0538
Trypanosoma cruzi hypothetical protein, conserved 0.0115 0.0892 0.5357
Trichomonas vaginalis rotamase, putative 0.0032 0.0115 0.0524
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0115 0.0892 0.0969
Brugia malayi hypothetical protein 0.0043 0.0222 0.0134
Schistosoma mansoni steroid hormone receptor ad4bp 0.0081 0.0578 0.0578
Loa Loa (eye worm) hypothetical protein 0.0043 0.0222 0.0134
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0115 0.0892 0.0969
Entamoeba histolytica hypothetical protein 0.0311 0.2713 1
Schistosoma mansoni smad1 5 8 and 0.0068 0.0449 0.0449
Onchocerca volvulus 0.0115 0.0892 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0049 0.0279 0.2354
Brugia malayi steroid hormone receptor 0.0081 0.0578 0.0534
Schistosoma mansoni nuclear receptor 0.0038 0.0179 0.0179
Brugia malayi MH2 domain containing protein 0.0991 0.902 1
Loa Loa (eye worm) Pin1-type peptidyl-prolyl cis-trans isomerase 0.0032 0.0123 0.0023
Loa Loa (eye worm) hypothetical protein 0.0806 0.7304 0.8076
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0038 0.0179 0.0077
Loa Loa (eye worm) Smad1 0.0068 0.0449 0.0389
Schistosoma mansoni hypothetical protein 0.0032 0.0122 0.0122
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0278 0.24 0.3024
Schistosoma mansoni Smad4 0.003 0.0102 0.0102

Activities

Activity type Activity value Assay description Source Reference
clogP = 5.99 Calculated partition coefficient (clogP) (Daylight) ChEMBL. 10999468
IC50 (binding) = 35 nM Inhibition of mitogen-activated protein kinase p38 alpha 2 ChEMBL. 10999468
IC50 (binding) = 35 nM Inhibition of mitogen-activated protein kinase p38 alpha 2 ChEMBL. 10999468
IC50 (functional) = 60 nM Inhibition of TNF and IL-1 induced IL-6 production in human chondro-sarcoma SW 1353 cells ChEMBL. 10999468
IC50 (functional) = 60 nM Inhibition of TNF and IL-1 induced IL-6 production in human chondro-sarcoma SW 1353 cells ChEMBL. 10999468
Solubility = 46 ug ml-1 Aqueous solubility of the compound was determined at pH 7.5 ChEMBL. 10999468

Phenotypes

Whole-cell/tissue/organism interactions

Species name Source Reference Is orphan
Homo sapiens ChEMBL23 10999468

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

1 literature reference was collected for this gene.

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