Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Loa Loa (eye worm) | RNA recognition domain-containing protein domain-containing protein | 0.0127 | 0.1741 | 0.2372 |
Plasmodium falciparum | phd finger protein, putative | 0.0061 | 0.0628 | 0.615 |
Brugia malayi | RNA recognition motif domain containing protein | 0.0127 | 0.1741 | 0.2372 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, apicoplast, putative | 0.0029 | 0.0079 | 0.0376 |
Brugia malayi | jmjC domain containing protein | 0.0201 | 0.2982 | 0.4107 |
Trichomonas vaginalis | DNA polymerase eta, putative | 0.0122 | 0.1649 | 0.1956 |
Echinococcus multilocularis | terminal deoxycytidyl transferase rev1 | 0.0122 | 0.1649 | 0.4702 |
Leishmania major | acetoin dehydrogenase e3 component-like protein | 0.0029 | 0.0079 | 0.0036 |
Echinococcus multilocularis | muscleblind protein 1 | 0.0145 | 0.2043 | 0.5856 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0087 | 0.1057 | 0.1018 |
Mycobacterium tuberculosis | Probable membrane NADH dehydrogenase NdhA | 0.0189 | 0.2789 | 0.5425 |
Entamoeba histolytica | exodeoxyribonuclease III, putative | 0.0041 | 0.0293 | 0.0792 |
Echinococcus granulosus | PHD finger protein rhinoceros | 0.0061 | 0.0628 | 0.1713 |
Trypanosoma brucei | mitochondrial DNA polymerase beta | 0.0616 | 1 | 1 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0061 | 0.0628 | 0.2929 |
Plasmodium vivax | hypothetical protein, conserved | 0.0061 | 0.0628 | 0.615 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0343 | 0.0839 |
Echinococcus multilocularis | tyrosyl DNA phosphodiesterase 1 | 0.0213 | 0.3194 | 0.9227 |
Trypanosoma brucei | trypanothione reductase | 0.0083 | 0.0994 | 0.0955 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0087 | 0.1057 | 0.1018 |
Onchocerca volvulus | 0.0065 | 0.0685 | 0.0074 | |
Entamoeba histolytica | deoxycytidyl transferase, putative | 0.0122 | 0.1649 | 0.5096 |
Echinococcus granulosus | tyrosyl DNA phosphodiesterase 1 | 0.0213 | 0.3194 | 0.9227 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.1011 | 0.0972 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0846 | 0.2066 |
Plasmodium falciparum | thioredoxin reductase | 0.0029 | 0.0079 | 0.0376 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.018 | 0.0138 |
Plasmodium falciparum | glutathione reductase | 0.0083 | 0.0994 | 1 |
Echinococcus granulosus | 5'partial|histone lysine N methyltransferase SETDB2 | 0.0062 | 0.0644 | 0.1761 |
Echinococcus multilocularis | arachidonate 5 lipoxygenase | 0.0122 | 0.1658 | 0.4729 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.1011 | 0.0972 |
Mycobacterium tuberculosis | NADPH-dependent mycothiol reductase Mtr | 0.0083 | 0.0994 | 0.1832 |
Echinococcus granulosus | expressed protein | 0.0036 | 0.0194 | 0.0443 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0038 | 0.0231 | 0.0189 |
Leishmania major | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Mycobacterium tuberculosis | Probable NADH dehydrogenase Ndh | 0.0189 | 0.2789 | 0.5425 |
Trichomonas vaginalis | DNA polymerase IV / kappa, putative | 0.0122 | 0.1649 | 0.1956 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0293 | 0.0715 |
Brugia malayi | jmjC domain containing protein | 0.0074 | 0.0846 | 0.1122 |
Mycobacterium tuberculosis | Probable oxidoreductase | 0.021 | 0.3146 | 0.6139 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Treponema pallidum | exodeoxyribonuclease (exoA) | 0.0041 | 0.0293 | 1 |
Brugia malayi | hypothetical protein | 0.0161 | 0.2312 | 0.317 |
Echinococcus multilocularis | dihydrolipoamide dehydrogenase | 0.0029 | 0.0079 | 0.0105 |
Plasmodium vivax | SET domain protein, putative | 0.0065 | 0.0685 | 0.6742 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0325 | 0.5075 | 1 |
Trypanosoma brucei | DNA polymerase beta thumb, putative | 0.0087 | 0.1057 | 0.1018 |
Schistosoma mansoni | jumonji/arid domain-containing protein | 0.0074 | 0.0846 | 0.2066 |
Trypanosoma brucei | unspecified product | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0122 | 0.1649 | 0.1612 |
Leishmania major | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, apicoplast | 0.0029 | 0.0079 | 0.0376 |
Echinococcus granulosus | terminal deoxycytidyl transferase rev1 | 0.0122 | 0.1649 | 0.4702 |
Loa Loa (eye worm) | ImpB/MucB/SamB family protein | 0.0122 | 0.1649 | 0.2243 |
Loa Loa (eye worm) | glutaminase | 0.0267 | 0.4095 | 0.5662 |
Echinococcus granulosus | dihydrolipoamide dehydrogenase | 0.0029 | 0.0079 | 0.0105 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.0685 | 0.1671 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Mycobacterium ulcerans | glutaminase | 0.0267 | 0.4095 | 0.8039 |
Entamoeba histolytica | peptidyl-prolyl cis-trans isomerase, putative | 0.0035 | 0.018 | 0.0435 |
Plasmodium falciparum | dihydrolipoyl dehydrogenase, mitochondrial | 0.0029 | 0.0079 | 0.0376 |
Echinococcus granulosus | transcription factor Dp 1 | 0.0123 | 0.1677 | 0.4786 |
Toxoplasma gondii | NADPH-glutathione reductase | 0.0029 | 0.0079 | 0.0179 |
Loa Loa (eye worm) | glutaminase 2 | 0.0267 | 0.4095 | 0.5662 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0292 | 0.4519 | 0.4495 |
Brugia malayi | glutaminase DH11.1 | 0.0267 | 0.4095 | 0.5662 |
Toxoplasma gondii | hypothetical protein | 0.0099 | 0.1272 | 0.6153 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1741 | 0.4251 |
Loa Loa (eye worm) | Pin1-type peptidyl-prolyl cis-trans isomerase | 0.0036 | 0.0194 | 0.0211 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0122 | 0.1649 | 0.2243 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Loa Loa (eye worm) | tyrosyl-DNA phosphodiesterase | 0.0213 | 0.3194 | 0.4402 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0616 | 1 | 1 |
Trypanosoma brucei | mitochondrial DNA polymerase beta-PAK | 0.0292 | 0.4519 | 0.4495 |
Echinococcus granulosus | Transcription factor JmjC domain containing protein | 0.0201 | 0.2982 | 0.8608 |
Echinococcus granulosus | geminin | 0.0182 | 0.2663 | 0.7673 |
Mycobacterium tuberculosis | Conserved hypothetical protein | 0.0122 | 0.1649 | 0.3142 |
Onchocerca volvulus | 0.0513 | 0.8251 | 1 | |
Schistosoma mansoni | DNA polymerase IV / kappa | 0.0038 | 0.0231 | 0.0565 |
Schistosoma mansoni | glutaminase | 0.0267 | 0.4095 | 1 |
Plasmodium falciparum | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0293 | 0.2622 |
Mycobacterium tuberculosis | Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) | 0.0041 | 0.0293 | 0.0428 |
Leishmania major | peptidyl-prolyl cis-trans isomerase/rotamase, putative,PPIase, putative | 0.0035 | 0.018 | 0.0138 |
Loa Loa (eye worm) | hypothetical protein | 0.0065 | 0.0685 | 0.0896 |
Echinococcus multilocularis | Transcription factor, JmjC domain containing protein | 0.0201 | 0.2982 | 0.8608 |
Brugia malayi | Pre-SET motif family protein | 0.0065 | 0.0685 | 0.0896 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1741 | 0.4251 |
Giardia lamblia | Endonuclease/Exonuclease/phosphatase | 0.0041 | 0.0293 | 0.1554 |
Loa Loa (eye worm) | RNA binding protein | 0.0127 | 0.1741 | 0.2372 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Schistosoma mansoni | rotamase | 0.0036 | 0.0194 | 0.0474 |
Mycobacterium tuberculosis | Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB | 0.0189 | 0.2789 | 0.5425 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Brugia malayi | Tyrosyl-DNA phosphodiesterase family protein | 0.0213 | 0.3194 | 0.4402 |
Mycobacterium leprae | DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE | 0.021 | 0.3146 | 1 |
Leishmania major | DNA polymerase kappa, putative | 0.0038 | 0.0231 | 0.0189 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0145 | 0.204 | 0.2006 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease | 0.0041 | 0.0293 | 0.0251 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0126 | 0.173 | 0.2357 |
Schistosoma mansoni | lipoxygenase | 0.0122 | 0.1658 | 0.4048 |
Schistosoma mansoni | dihydrolipoamide dehydrogenase | 0.0029 | 0.0079 | 0.0193 |
Trypanosoma brucei | dihydrolipoyl dehydrogenase | 0.0029 | 0.0079 | 0.0036 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0083 | 0.0994 | 0.0955 |
Loa Loa (eye worm) | PHD-finger family protein | 0.0061 | 0.0628 | 0.0817 |
Leishmania major | mitochondrial DNA polymerase beta-PAK, putative | 0.0292 | 0.4519 | 0.4495 |
Brugia malayi | RNA binding protein | 0.0127 | 0.1741 | 0.2372 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0029 | 0.0079 | 0.0036 |
Giardia lamblia | DINP protein human, muc B family | 0.0122 | 0.1649 | 1 |
Schistosoma mansoni | DNA polymerase eta | 0.0229 | 0.3458 | 0.8443 |
Echinococcus multilocularis | peregrin | 0.0061 | 0.0628 | 0.1713 |
Echinococcus granulosus | thioredoxin glutathione reductase | 0.0084 | 0.1013 | 0.2841 |
Plasmodium vivax | DNA repair protein REV1, putative | 0.0038 | 0.0231 | 0.1978 |
Brugia malayi | TAR-binding protein | 0.0127 | 0.1741 | 0.2372 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0122 | 0.1649 | 0.3142 |
Plasmodium vivax | AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative | 0.0041 | 0.0293 | 0.2622 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0343 | 0.0839 |
Mycobacterium ulcerans | hypothetical protein | 0.0325 | 0.5075 | 1 |
Brugia malayi | Pre-SET motif family protein | 0.045 | 0.72 | 1 |
Trypanosoma brucei | peptidyl-prolyl cis-trans isomerase/rotamase, putative | 0.0035 | 0.018 | 0.0138 |
Leishmania major | DNA polymerase eta, putative | 0.0229 | 0.3458 | 0.3429 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0084 | 0.1011 | 0.0972 |
Echinococcus granulosus | histone lysine methyltransferase setb | 0.0065 | 0.0685 | 0.1878 |
Entamoeba histolytica | tyrosyl-DNA phosphodiesterase, putative | 0.0213 | 0.3194 | 1 |
Echinococcus granulosus | tar DNA binding protein | 0.0127 | 0.1741 | 0.4972 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0231 | 0.0189 |
Loa Loa (eye worm) | jmjC domain-containing protein | 0.0074 | 0.0846 | 0.1122 |
Plasmodium vivax | dihydrolipoyl dehydrogenase, mitochondrial, putative | 0.0029 | 0.0079 | 0.0376 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Loa Loa (eye worm) | exodeoxyribonuclease III family protein | 0.0041 | 0.0293 | 0.0349 |
Echinococcus multilocularis | transcription factor Dp 1 | 0.0123 | 0.1677 | 0.4786 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0231 | 0.0189 |
Echinococcus granulosus | dna polymerase eta | 0.0229 | 0.3458 | 1 |
Mycobacterium tuberculosis | NAD(P)H quinone reductase LpdA | 0.021 | 0.3146 | 0.6139 |
Trypanosoma cruzi | trypanothione reductase, putative | 0.0029 | 0.0079 | 0.0036 |
Trypanosoma cruzi | peptidyl-prolyl cis-trans isomerase | 0.0035 | 0.018 | 0.0138 |
Trypanosoma brucei | unspecified product | 0.0084 | 0.1011 | 0.0972 |
Brugia malayi | ImpB/MucB/SamB family protein | 0.0229 | 0.3458 | 0.4771 |
Trichomonas vaginalis | glutathione reductase, putative | 0.0029 | 0.0079 | 0.0044 |
Trypanosoma cruzi | hypothetical protein, conserved | 0.0038 | 0.0231 | 0.0189 |
Mycobacterium tuberculosis | Probable dehydrogenase | 0.0189 | 0.2789 | 0.5425 |
Echinococcus granulosus | dna polymerase kappa | 0.0122 | 0.1649 | 0.4702 |
Echinococcus multilocularis | DNA (apurinic or apyrimidinic site) lyase | 0.0041 | 0.0293 | 0.0731 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Toxoplasma gondii | PHD-finger domain-containing protein | 0.0061 | 0.0628 | 0.2929 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Echinococcus multilocularis | muscleblind protein | 0.0145 | 0.2043 | 0.5856 |
Mycobacterium tuberculosis | Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) | 0.0122 | 0.1649 | 0.3142 |
Loa Loa (eye worm) | hypothetical protein | 0.0061 | 0.0628 | 0.0817 |
Brugia malayi | polk-prov protein | 0.0038 | 0.0231 | 0.0263 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0038 | 0.0231 | 0.0189 |
Toxoplasma gondii | thioredoxin reductase | 0.0083 | 0.0994 | 0.4763 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0213 | 0.3194 | 0.3164 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0038 | 0.0231 | 0.0189 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase, point mutation | 0.0029 | 0.0079 | 0.0036 |
Echinococcus multilocularis | geminin | 0.0182 | 0.2663 | 0.7673 |
Schistosoma mansoni | histone-lysine n-methyltransferase suv9 | 0.0065 | 0.0685 | 0.1671 |
Loa Loa (eye worm) | hypothetical protein | 0.0229 | 0.3458 | 0.4771 |
Brugia malayi | glutathione reductase | 0.0083 | 0.0994 | 0.1329 |
Loa Loa (eye worm) | hypothetical protein | 0.0038 | 0.0231 | 0.0263 |
Trypanosoma cruzi | DNA polymerase eta, putative | 0.0229 | 0.3458 | 0.3429 |
Toxoplasma gondii | exonuclease III APE | 0.0041 | 0.0293 | 0.1249 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0231 | 0.0189 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2663 | 0.6502 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2043 | 0.2794 |
Brugia malayi | Muscleblind-like protein | 0.0145 | 0.2043 | 0.2794 |
Schistosoma mansoni | terminal deoxycytidyl transferase | 0.0122 | 0.1649 | 0.4026 |
Brugia malayi | GTP-binding regulatory protein Gs alpha-S chain, putative | 0.0044 | 0.0343 | 0.0419 |
Schistosoma mansoni | lipoxygenase | 0.0085 | 0.1037 | 0.2531 |
Trypanosoma brucei | unspecified product | 0.0084 | 0.1011 | 0.0972 |
Echinococcus granulosus | arachidonate 5 lipoxygenase | 0.0122 | 0.1658 | 0.4729 |
Schistosoma mansoni | ap endonuclease | 0.0041 | 0.0293 | 0.0715 |
Trichomonas vaginalis | conserved hypothetical protein | 0.0036 | 0.0194 | 0.0184 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Trichomonas vaginalis | glutaminase, putative | 0.0267 | 0.4095 | 0.4937 |
Schistosoma mansoni | Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) | 0.0044 | 0.0343 | 0.0839 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0293 | 0.0304 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma brucei | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0213 | 0.3194 | 0.3164 |
Onchocerca volvulus | 0.0161 | 0.2312 | 0.2208 | |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trichomonas vaginalis | rotamase, putative | 0.0035 | 0.018 | 0.0167 |
Leishmania major | apurinic/apyrimidinic endonuclease-redox protein | 0.0041 | 0.0293 | 0.0251 |
Loa Loa (eye worm) | GTP-binding regulatory protein Gs alpha-S chain | 0.0044 | 0.0343 | 0.0419 |
Schistosoma mansoni | hypothetical protein | 0.0061 | 0.0628 | 0.1534 |
Wolbachia endosymbiont of Brugia malayi | exonuclease III | 0.0041 | 0.0293 | 1 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0343 | 0.0879 |
Echinococcus multilocularis | dna polymerase kappa | 0.0122 | 0.1649 | 0.4702 |
Toxoplasma gondii | histone lysine methyltransferase SET/SUV39 | 0.0065 | 0.0685 | 0.3212 |
Giardia lamblia | DNA damage repair protein | 0.0038 | 0.0231 | 0.1172 |
Plasmodium falciparum | DNA repair protein REV1, putative | 0.0038 | 0.0231 | 0.1978 |
Leishmania major | trypanothione reductase | 0.0083 | 0.0994 | 0.0955 |
Trypanosoma cruzi | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma cruzi | DNA damage repair protein, putative | 0.0038 | 0.0231 | 0.0189 |
Schistosoma mansoni | rab geranylgeranyl transferase alpha subunit | 0.0122 | 0.1649 | 0.4026 |
Leishmania major | DNA polymerase kappa, putative,DNA polymerase IV, putative | 0.0122 | 0.1649 | 0.1612 |
Echinococcus multilocularis | expressed protein | 0.0036 | 0.0194 | 0.0443 |
Brugia malayi | PHD-finger family protein | 0.0061 | 0.0628 | 0.0817 |
Echinococcus multilocularis | PHD finger protein rhinoceros | 0.0061 | 0.0628 | 0.1713 |
Loa Loa (eye worm) | TAR-binding protein | 0.0127 | 0.1741 | 0.2372 |
Leishmania major | DNA polymerase eta, putative | 0.0145 | 0.204 | 0.2006 |
Brugia malayi | Thioredoxin reductase | 0.0083 | 0.0994 | 0.1329 |
Schistosoma mansoni | tyrosyl-DNA phosphodiesterase | 0.0213 | 0.3194 | 0.7798 |
Trichomonas vaginalis | rotamase, putative | 0.0036 | 0.0194 | 0.0184 |
Mycobacterium tuberculosis | Probable reductase | 0.0189 | 0.2789 | 0.5425 |
Echinococcus multilocularis | thioredoxin glutathione reductase | 0.0084 | 0.1013 | 0.2841 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta, putative | 0.0616 | 1 | 1 |
Echinococcus granulosus | jumonji domain containing protein | 0.0085 | 0.1033 | 0.29 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0343 | 0.0879 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1741 | 0.4251 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Loa Loa (eye worm) | hypothetical protein | 0.0105 | 0.1367 | 0.185 |
Brugia malayi | Pin1-type peptidyl-prolyl cis-trans isomerase, BmPin1 | 0.0036 | 0.0194 | 0.0211 |
Loa Loa (eye worm) | thioredoxin reductase | 0.0083 | 0.0994 | 0.1329 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0038 | 0.0231 | 0.0942 |
Echinococcus granulosus | muscleblind protein | 0.0145 | 0.2043 | 0.5856 |
Leishmania major | tyrosyl-DNA phosphodiesterase 1 | 0.0213 | 0.3194 | 0.3164 |
Plasmodium vivax | thioredoxin reductase, putative | 0.0083 | 0.0994 | 1 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Echinococcus multilocularis | histone lysine N methyltransferase SETMAR | 0.0065 | 0.0685 | 0.1878 |
Schistosoma mansoni | hypothetical protein | 0.0182 | 0.2663 | 0.6502 |
Loa Loa (eye worm) | hypothetical protein | 0.0161 | 0.2312 | 0.317 |
Trypanosoma cruzi | dihydrolipoyl dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Toxoplasma gondii | pyruvate dehydrogenase complex subunit PDH-E3II | 0.0029 | 0.0079 | 0.0179 |
Brugia malayi | dihydrolipoyl dehydrogenase, mitochondrial precursor, putative | 0.0029 | 0.0079 | 0.005 |
Mycobacterium tuberculosis | Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras | 0.021 | 0.3146 | 0.6139 |
Trypanosoma brucei | chrX additional, unordered contigs | 0.0038 | 0.0231 | 0.0189 |
Echinococcus granulosus | lysine specific demethylase 5A | 0.0074 | 0.0846 | 0.2351 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0122 | 0.1649 | 0.1612 |
Loa Loa (eye worm) | glutathione reductase | 0.0083 | 0.0994 | 0.1329 |
Echinococcus multilocularis | jumonji domain containing protein | 0.0085 | 0.1033 | 0.29 |
Mycobacterium tuberculosis | Putative ferredoxin reductase | 0.0189 | 0.2789 | 0.5425 |
Echinococcus granulosus | guanine nucleotide binding protein Gs subunit | 0.0044 | 0.0343 | 0.0879 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.0685 | 0.1671 |
Trypanosoma brucei | hypothetical protein, conserved | 0.0038 | 0.0231 | 0.0189 |
Trichomonas vaginalis | mercuric reductase, putative | 0.0029 | 0.0079 | 0.0044 |
Brugia malayi | Bromodomain containing protein | 0.0061 | 0.0628 | 0.0817 |
Echinococcus multilocularis | tar DNA binding protein | 0.0127 | 0.1741 | 0.4972 |
Trypanosoma brucei | DNA polymerase eta, putative | 0.0229 | 0.3458 | 0.3429 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1741 | 0.4251 |
Schistosoma mansoni | jumonji domain containing protein | 0.0159 | 0.2286 | 0.5582 |
Giardia lamblia | PHD finger protein 15 | 0.0061 | 0.0628 | 0.3644 |
Trypanosoma cruzi | tyrosyl-DNA Phosphodiesterase (Tdp1), putative | 0.0213 | 0.3194 | 0.3164 |
Echinococcus granulosus | peregrin | 0.0061 | 0.0628 | 0.1713 |
Echinococcus multilocularis | lysine specific demethylase 5A | 0.0074 | 0.0846 | 0.2351 |
Trypanosoma brucei | DNA damage repair protein, putative | 0.0038 | 0.0231 | 0.0189 |
Schistosoma mansoni | bromodomain-containing nuclear protein 1 brd1 | 0.0061 | 0.0628 | 0.1534 |
Echinococcus multilocularis | histone lysine methyltransferase setb histone lysine methyltransferase eggless | 0.0065 | 0.0685 | 0.1878 |
Toxoplasma gondii | ImpB/MucB/SamB family protein | 0.0145 | 0.204 | 1 |
Toxoplasma gondii | peptidylprolyl isomerase | 0.0035 | 0.018 | 0.0686 |
Echinococcus granulosus | DNA apurinic or apyrimidinic site lyase | 0.0041 | 0.0293 | 0.0731 |
Leishmania major | DNA damage repair protein, putative | 0.0038 | 0.0231 | 0.0189 |
Schistosoma mansoni | tar DNA-binding protein | 0.0127 | 0.1741 | 0.4251 |
Chlamydia trachomatis | dihydrolipoyl dehydrogenase | 0.0029 | 0.0079 | 0.5 |
Trichomonas vaginalis | ap endonuclease, putative | 0.0041 | 0.0293 | 0.0304 |
Trypanosoma brucei | DNA polymerase IV, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma cruzi | DNA polymerase beta thumb, putative | 0.0087 | 0.1057 | 0.1018 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Giardia lamblia | NADH oxidase lateral transfer candidate | 0.0029 | 0.0079 | 0.0223 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Mycobacterium ulcerans | hypothetical protein | 0.0038 | 0.0231 | 0.0305 |
Loa Loa (eye worm) | pre-SET domain-containing protein family protein | 0.045 | 0.72 | 1 |
Trichomonas vaginalis | set domain proteins, putative | 0.0513 | 0.8251 | 1 |
Trypanosoma cruzi | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0293 | 0.0251 |
Toxoplasma gondii | BRCA1 C Terminus (BRCT) domain-containing protein | 0.0038 | 0.0231 | 0.0942 |
Brugia malayi | exodeoxyribonuclease III family protein | 0.0041 | 0.0293 | 0.0349 |
Schistosoma mansoni | histone-lysine n-methyltransferase setb1 | 0.0065 | 0.0685 | 0.1671 |
Trypanosoma brucei | apurinic/apyrimidinic endonuclease, putative | 0.0041 | 0.0293 | 0.0251 |
Echinococcus multilocularis | guanine nucleotide binding protein G(s) subunit | 0.0044 | 0.0343 | 0.0879 |
Mycobacterium ulcerans | DNA polymerase IV | 0.0122 | 0.1649 | 0.3142 |
Loa Loa (eye worm) | hypothetical protein | 0.0145 | 0.2043 | 0.2794 |
Plasmodium vivax | glutathione reductase, putative | 0.0083 | 0.0994 | 1 |
Plasmodium falciparum | thioredoxin reductase | 0.0083 | 0.0994 | 1 |
Plasmodium falciparum | glutathione reductase | 0.0029 | 0.0079 | 0.0376 |
Leishmania major | 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein | 0.0029 | 0.0079 | 0.0036 |
Echinococcus multilocularis | dna polymerase eta | 0.0229 | 0.3458 | 1 |
Mycobacterium ulcerans | exodeoxyribonuclease III protein XthA | 0.0041 | 0.0293 | 0.0428 |
Trypanosoma cruzi | mitochondrial DNA polymerase beta-PAK, putative | 0.0106 | 0.1377 | 0.1339 |
Trypanosoma cruzi | dihydrolipoamide dehydrogenase, putative | 0.0029 | 0.0079 | 0.0036 |
Trypanosoma brucei | DNA polymerase kappa, putative | 0.0122 | 0.1649 | 0.1612 |
Trypanosoma brucei | dihydrolipoamide dehydrogenase | 0.0029 | 0.0079 | 0.0036 |
Activity type | Activity value | Assay description | Source | Reference |
---|---|---|---|---|
GI (functional) | = 14 % | Growth inhibition of human HOP62 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human HCT116 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human SF539 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human UACC62 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human OVCAR-3 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human SN12C cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human DU145 cells at 10 uM | ChEMBL. | 18630891 |
GI (functional) | = 14 % | Growth inhibition of human MDA-MB-435 cells at 10 uM | ChEMBL. | 18630891 |
Inhibition (binding) | = 50 % | Inhibition of human recombinant topoisomerase 1 assessed as DNA cleavage relative to 1 uM camptothecin | ChEMBL. | 18630891 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.
1 literature reference was collected for this gene.