Detailed information for compound 100899

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 415.287 | Formula: C18H19BrN6O
  • H donors: 0 H acceptors: 4 LogP: 2.55 Rotable bonds: 4
    Rule of 5 violations (Lipinski): 1
  • SMILES: O=C1CCCN1c1cccc(c1)Cn1c(Br)nc2c1ncnc2N(C)C
  • InChi: 1S/C18H19BrN6O/c1-23(2)16-15-17(21-11-20-16)25(18(19)22-15)10-12-5-3-6-13(9-12)24-8-4-7-14(24)26/h3,5-6,9,11H,4,7-8,10H2,1-2H3
  • InChiKey: ACOUGQZTBDAPRO-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0112 0.0134
Schistosoma mansoni retinoic acid receptor RXR 0.0061 0.0461 0.061
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.015 0.0197
Schistosoma mansoni RAR-like nuclear receptor 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.0197
Schistosoma mansoni nuclear receptor nhr-48 0.0029 0.0112 0.0147
Giardia lamblia GTP-binding nuclear protein RAN/TC4 0.0022 0.0042 0.0513
Echinococcus granulosus importin subunit beta 1 0.003 0.0128 0.0169
Echinococcus multilocularis dna polymerase eta 0.002 0.0017 0.0019
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0027 0.0089 0.0117
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Loa Loa (eye worm) TAR-binding protein 0.0252 0.2513 0.3329
Trypanosoma brucei Phosphatidylinositol 3-kinase tor1 0.0045 0.0281 0.0415
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0028 0.0017
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0028 0.0036
Echinococcus granulosus GPCR family 2 0.0083 0.0697 0.0923
Leishmania major target of rapamycin (TOR) kinase 1, putative 0.0045 0.0281 0.0392
Loa Loa (eye worm) CXXC zinc finger family protein 0.0031 0.0136 0.0178
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Echinococcus multilocularis jumonji domain containing protein 0.0091 0.0782 0.0943
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Loa Loa (eye worm) intermediate filament tail domain-containing protein 0.0113 0.1011 0.1339
Trypanosoma brucei mitochondrial DNA polymerase beta-PAK 0.0306 0.3093 0.4577
Loa Loa (eye worm) hypothetical protein 0.072 0.7547 1
Onchocerca volvulus 0.0148 0.1397 0.5208
Brugia malayi Pre-SET motif family protein 0.0034 0.017 0.0224
Loa Loa (eye worm) nuclear receptor nhr-7B 0.0029 0.0112 0.0147
Trypanosoma brucei phosphatidylinositol 3-kinase tor, putative 0.0021 0.0028 0.0041
Echinococcus multilocularis tar DNA binding protein 0.0252 0.2513 0.3034
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0461 0.061
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0061 0.0461 0.0556
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0287
Schistosoma mansoni lamin 0.0113 0.1011 0.1339
Brugia malayi CHE-14 protein 0.0048 0.0313 0.0414
Echinococcus multilocularis peptidase Clp (S14 family) 0.0472 0.4878 0.5891
Schistosoma mansoni hepatocyte nuclear factor 4-alpha (hnf-4-alpha) 0.0029 0.0112 0.0147
Brugia malayi glutathione reductase 0.0106 0.0935 0.1238
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.0106 0.0935 0.092
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Echinococcus granulosus nuclear receptor subfamily 1 group D 0.0032 0.015 0.0197
Schistosoma mansoni hypothetical protein 0.0046 0.0295 0.0389
Mycobacterium ulcerans esterase/lipase LipP 0.0148 0.1397 0.1833
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.004 0.0234 0.0288
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0779 0.113
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0625 0.6515 0.8633
Brugia malayi Calcitonin receptor-like protein seb-1 0.0264 0.2634 0.349
Echinococcus multilocularis GTP binding nuclear protein Ran 0.0022 0.0042 0.0049
Loa Loa (eye worm) latrophilin receptor protein 2 0.0083 0.0697 0.0923
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.0197
Schistosoma mansoni cpg binding protein 0.0031 0.0136 0.0178
Schistosoma mansoni hypothetical protein 0.0046 0.0295 0.0389
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0066 0.0197
Brugia malayi hypothetical protein 0.0114 0.1025 0.1357
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0148 0.1397 0.1833
Brugia malayi MH2 domain containing protein 0.0042 0.0249 0.0329
Echinococcus multilocularis retinoic acid receptor rxr beta a retinoic acid receptor rxr alpha a retinoic acid receptor rxr alpha 0.0029 0.0112 0.0134
Trichomonas vaginalis chromobox protein, putative 0.0078 0.064 0.2349
Mycobacterium tuberculosis Probable oxidoreductase 0.0268 0.2678 0.2666
Echinococcus granulosus chromobox protein 1 0.0078 0.064 0.0847
Mycobacterium tuberculosis Conserved protein 0.0148 0.1397 0.1383
Brugia malayi conserved hypotetical protein 0.0029 0.0112 0.0147
Brugia malayi nuclear receptor RXR 0.0029 0.0112 0.0147
Loa Loa (eye worm) hypothetical protein 0.002 0.0017 0.0021
Echinococcus multilocularis jumonji domain containing 1A 0.0021 0.0028 0.0033
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0031 0.0046
Brugia malayi intermediate filament protein 0.0113 0.1011 0.1339
Schistosoma mansoni zinc finger protein 0.0029 0.0112 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0061 0.0461 0.061
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0061 0.0461 0.0556
Brugia malayi Nuclear hormone receptor-like 1 0.0032 0.015 0.0197
Trypanosoma cruzi importin beta-1 subunit, putative 0.0025 0.0066 0.0074
Loa Loa (eye worm) heterochromatin protein 1 0.0078 0.064 0.0847
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor1 0.0045 0.0281 0.0392
Schistosoma mansoni hypothetical protein 0.0046 0.0295 0.0389
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0061 0.0461 0.061
Loa Loa (eye worm) nuclear hormone receptor 0.0029 0.0112 0.0147
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0234 0.0274
Mycobacterium tuberculosis Probable lipase LipE 0.0148 0.1397 0.1383
Onchocerca volvulus 0.0148 0.1397 0.5208
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0276
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0036
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0061 0.0461 0.061
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0067 0.0525 0.0694
Brugia malayi beta-lactamase family protein 0.0148 0.1397 0.185
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0461 0.061
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0321 0.0424
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0059 0.0171
Schistosoma mansoni smad1 5 8 and 0.0042 0.0249 0.0329
Mycobacterium tuberculosis Conserved protein 0.0148 0.1397 0.1383
Echinococcus multilocularis ATP dependent Clp protease proteolytic subunit 0.072 0.7547 0.9115
Mycobacterium leprae Probable lipase LipE 0.0148 0.1397 0.1538
Trichomonas vaginalis PIKK family atypical protein kinase 0.003 0.0123 0.0408
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0061 0.0461 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0029 0.0112 0.0369
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Giardia lamblia NADH oxidase lateral transfer candidate 0.0037 0.0194 0.362
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0061 0.0461 0.0556
Brugia malayi ecdysone receptor 0.0029 0.0112 0.0147
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Echinococcus granulosus cytoplasmic intermediate filament protein 0.0054 0.0385 0.0509
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0059 0.0171
Leishmania major GTP-binding protein, putative 0.0022 0.0042 0.0037
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0255
Loa Loa (eye worm) nucleolar RNA-associated protein alpha 0.0326 0.3301 0.4374
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0034 0.017 0.0189
Trypanosoma brucei mitochondrial DNA polymerase beta 0.0647 0.6758 1
Trichomonas vaginalis chromobox protein, putative 0.0078 0.064 0.2349
Schistosoma mansoni ferritin 0.0045 0.0279 0.0369
Loa Loa (eye worm) abnormal chemotaxis protein 14 0.0048 0.0313 0.0414
Brugia malayi Latrophilin receptor protein 2 0.0083 0.0697 0.0923
Schistosoma mansoni patched 1 0.0048 0.0313 0.0414
Loa Loa (eye worm) hypothetical protein 0.0113 0.1011 0.1339
Onchocerca volvulus Bile acid receptor homolog 0.0061 0.0461 0.1718
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0461 0.0556
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.0083 0.0697 0.0841
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1397 0.5185
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0183 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0134 0.045
Trypanosoma cruzi trypanothione reductase, putative 0.0106 0.0935 0.1363
Schistosoma mansoni ran 0.0022 0.0042 0.0054
Echinococcus multilocularis mothers against decapentaplegic 5 0.0042 0.0249 0.03
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0061 0.0461 0.061
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0025
Echinococcus multilocularis PHD finger protein rhinoceros 0.0066 0.0506 0.061
Echinococcus granulosus dna polymerase eta 0.002 0.0017 0.0021
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0281 0.1001
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0037 0.0194 0.022
Brugia malayi nuclear hormone receptor family member odr-7 0.0029 0.0112 0.0147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0673 0.0891
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2513 0.3329
Toxoplasma gondii GTP-binding nuclear protein ran/tc4 0.0022 0.0042 0.0018
Wolbachia endosymbiont of Brugia malayi exonuclease III 0.004 0.0234 0.0054
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.004 0.0234 0.0322
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2513 0.3329
Loa Loa (eye worm) isocitrate dehydrogenase 0.0033 0.0158 0.0208
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0037 0.0194 0.0235
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0148 0.1397 0.185
Loa Loa (eye worm) cytoplasmic intermediate filament protein 0.006 0.0449 0.0594
Onchocerca volvulus 0.0148 0.1397 0.5208
Brugia malayi hypothetical protein 0.0027 0.0095 0.0124
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0281 0.1001
Schistosoma mansoni importin beta-1 0.003 0.0128 0.0169
Schistosoma mansoni ferritin 0.0045 0.0279 0.0369
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0112 0.0415
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.004 0.0234 0.0322
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0506 0.0635
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0037 0.0194 0.0177
Brugia malayi photoreceptor-specific nuclear receptor 0.0061 0.0461 0.061
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0158 0.0173
Loa Loa (eye worm) hypothetical protein 0.0052 0.0363 0.0479
Entamoeba histolytica hypothetical protein 0.0114 0.1025 1
Echinococcus granulosus lamin 0.0113 0.1011 0.1339
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0321 0.0424
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.072 0.7547 1
Schistosoma mansoni ecdysone-induced protein 78c (dr-78) 0.0032 0.015 0.0197
Echinococcus multilocularis Niemann Pick C1 protein 0.0159 0.1507 0.182
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0085 0.0265
Loa Loa (eye worm) jmjC domain-containing protein 0.0135 0.1256 0.1664
Schistosoma mansoni smad 0.0042 0.0249 0.0329
Plasmodium falciparum thioredoxin reductase 0.0106 0.0935 0.1207
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Brugia malayi Heterochromatin protein 1 0.0078 0.064 0.0847
Plasmodium vivax hypothetical protein, conserved 0.0066 0.0506 0.0635
Loa Loa (eye worm) phosphatidylinositol 3 0.0045 0.0281 0.0371
Echinococcus multilocularis chromobox protein 1 0.0078 0.064 0.0772
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.3093 0.4564
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0241 0.2389 0.2376
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Trichomonas vaginalis set domain proteins, putative 0.0268 0.2681 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.006 0.0172
Onchocerca volvulus Protein ultraspiracle homolog 0.0061 0.0461 0.1718
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.0111 0.0989 0.131
Schistosoma mansoni intermediate filament proteins 0.0113 0.1011 0.1339
Loa Loa (eye worm) glutathione reductase 0.0106 0.0935 0.1238
Mycobacterium tuberculosis Probable hydrolase 0.0148 0.1397 0.1383
Mycobacterium tuberculosis Probable bacterioferritin BfrA 0.0045 0.0279 0.0263
Toxoplasma gondii hypothetical protein 0.0248 0.2469 0.3247
Echinococcus multilocularis lysine specific demethylase 6a 0.0021 0.0028 0.0033
Echinococcus multilocularis Niemann Pick C1 protein 0.0111 0.0995 0.12
Schistosoma mansoni ap endonuclease 0.004 0.0234 0.0308
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0194 0.0263
Schistosoma mansoni jumonji domain containing protein 0.0021 0.0028 0.0036
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0048 0.0321 0.0424
Brugia malayi Steroid receptor seven-up type 2 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.0048 0.0313 0.0414
Brugia malayi Pre-SET motif family protein 0.0235 0.2332 0.309
Loa Loa (eye worm) PHD-finger family protein 0.0066 0.0506 0.0669
Brugia malayi beta-lactamase family protein 0.0148 0.1397 0.185
Echinococcus multilocularis beta LACTamase domain containing family member 0.0148 0.1397 0.1686
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 2 ClpP2 (endopeptidase CLP 2) 0.0472 0.4878 0.4869
Mycobacterium ulcerans hypothetical protein 0.0341 0.3465 0.458
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0148 0.1397 0.1383
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.006 0.0172
Echinococcus multilocularis nuclear receptor nhr 48 0.0029 0.0112 0.0134
Mycobacterium tuberculosis Probable esterase LipL 0.0148 0.1397 0.1383
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0061 0.0461 0.061
Trichomonas vaginalis DNA polymerase eta, putative 0.002 0.0017 0.0011
Loa Loa (eye worm) MH2 domain-containing protein 0.0612 0.6384 0.8459
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0321 0.0424
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0061 0.0461 0.061
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.004 0.0234 0.0308
Echinococcus granulosus FTZ F1 alpha 0.0061 0.0461 0.061
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Schistosoma mansoni nuclear receptor 0.0029 0.0112 0.0147
Brugia malayi cytoplasmic intermediate filament protein 0.006 0.0449 0.0594
Schistosoma mansoni jumonji domain containing protein 0.0171 0.1635 0.2166
Brugia malayi beta-lactamase 0.0148 0.1397 0.185
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0061 0.0461 0.061
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0114 0.1025 0.1357
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0029 0.0112 0.0147
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Brugia malayi MH2 domain containing protein 0.0612 0.6384 0.8459
Toxoplasma gondii hypothetical protein 0.0104 0.0923 0.119
Trypanosoma cruzi JmjC domain, hydroxylase, putative 0.0021 0.0028 0.0017
Brugia malayi chromobox protein homolog 3 0.0044 0.0271 0.0358
Schistosoma mansoni ap endonuclease 0.004 0.0234 0.0308
Echinococcus granulosus chromobox protein 1 0.0078 0.064 0.0847
Trypanosoma cruzi DNA polymerase beta thumb, putative 0.0091 0.0779 0.113
Echinococcus granulosus dna polymerase kappa 0.002 0.0017 0.0021
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1397 0.5185
Schistosoma mansoni chromobox protein 0.0078 0.064 0.0847
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0061 0.0461 0.061
Schistosoma mansoni ferritin light chain 0.0045 0.0279 0.0369
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0061 0.0461 0.061
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0112 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Leishmania major target of rapamycin kinase (TOR) kinase 3 0.0036 0.0183 0.0246
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1397 0.5185
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0042 0.0037
Schistosoma mansoni thyroid hormone receptor 0.0686 0.7176 0.9509
Schistosoma mansoni apoferritin-2 0.0045 0.0279 0.0369
Brugia malayi steroid hormone receptor 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.003 0.0128 0.0169
Schistosoma mansoni thyroid hormone receptor 0.0686 0.7176 0.9509
Echinococcus multilocularis expressed conserved protein 0.0104 0.0922 0.1113
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Brugia malayi MH1 domain containing protein 0.0023 0.0049 0.0063
Onchocerca volvulus 0.0029 0.0112 0.0415
Echinococcus multilocularis expressed protein 0.0045 0.0279 0.0336
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0037 0.0194 0.0287
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0042 0.0249 0.0329
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0037 0.0194 0.0263
Mycobacterium tuberculosis Probable lipase LipD 0.0148 0.1397 0.1383
Echinococcus multilocularis importin subunit beta 1 0.003 0.0128 0.0154
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0223
Schistosoma mansoni phosphatidylserine receptor 0.0021 0.0028 0.0036
Brugia malayi hypothetical protein 0.0032 0.015 0.0197
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.002 0.0017 0.0021
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.0083 0.0697 0.0923
Trypanosoma brucei unspecified product 0.002 0.0017 0.0025
Loa Loa (eye worm) steroid hormone receptor 0.0061 0.0461 0.061
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0033 0.0158 0.0142
Loa Loa (eye worm) hypothetical protein 0.0112 0.1009 0.1336
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0037 0.0194 0.0263
Schistosoma mansoni coup transcription factor 0.0061 0.0461 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0038 0.0211 0.0737
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Plasmodium falciparum GTP-binding nuclear protein RAN/TC4 0.0022 0.0042 0.0018
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0025
Loa Loa (eye worm) RNA binding protein 0.0252 0.2513 0.3329
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0061 0.0461 0.061
Trypanosoma brucei JmjC domain, hydroxylase, putative 0.0021 0.0028 0.0042
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0158 0.019
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0033 0.0158 0.0234
Leishmania major trypanothione reductase 0.0106 0.0935 0.1363
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0033 0.0158 0.019
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Echinococcus granulosus histone lysine methyltransferase setb 0.0034 0.017 0.0224
Echinococcus granulosus smad 0.0042 0.0249 0.0329
Brugia malayi Bromodomain containing protein 0.0066 0.0506 0.0669
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.002 0.0017 0.0021
Trypanosoma brucei PHD-zinc-finger like domain containing protein, putative 0.0021 0.0031 0.0046
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Echinococcus granulosus JmjC domain containing protein 4 0.0021 0.0028 0.0036
Echinococcus granulosus mothers against decapentaplegic 5 0.0042 0.0249 0.0329
Brugia malayi RNA binding protein 0.0252 0.2513 0.3329
Brugia malayi GTP-binding nuclear protein RAN/TC4 0.0022 0.0042 0.0054
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0307 0.1099
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0061 0.0461 0.061
Schistosoma mansoni lamin 0.0113 0.1011 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0158 0.021
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0028 0.0036
Echinococcus multilocularis sterol regulatory element binding protein 0.0048 0.0313 0.0377
Loa Loa (eye worm) DR-78 0.0029 0.0112 0.0147
Echinococcus granulosus FKBP12 rapamycin complex associated protein 0.0045 0.0281 0.0371
Echinococcus granulosus nuclear receptor nhr 48 0.0029 0.0112 0.0147
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0017 0.0021
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0264 0.2634 0.349
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Trypanosoma brucei GTP-binding nuclear protein rtb2, putative 0.0022 0.0042 0.0062
Leishmania major importin beta-1 subunit, putative 0.0025 0.0066 0.0074
Echinococcus multilocularis Nuclear hormone receptor HR96 0.0029 0.0112 0.0134
Plasmodium vivax glutathione reductase, putative 0.0106 0.0935 0.1207
Brugia malayi ImpB/MucB/SamB family protein 0.002 0.0017 0.0021
Entamoeba histolytica FKBP-rapamycin associated protein (FRAP), putative 0.0045 0.0281 0.2619
Echinococcus granulosus PHD finger protein rhinoceros 0.0066 0.0506 0.0669
Entamoeba histolytica hypothetical protein 0.0114 0.1025 1
Echinococcus granulosus cpg binding protein 0.0033 0.0155 0.0204
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0032 0.0149 0.0197
Echinococcus multilocularis musashi 0.0113 0.1011 0.122
Echinococcus multilocularis ferritin 0.0045 0.0279 0.0336
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0128 0.019
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0158 0.0234
Entamoeba histolytica phosphatidylinositol3-kinaseTor2, putative 0.0045 0.0281 0.2619
Toxoplasma gondii NADPH-glutathione reductase 0.0037 0.0194 0.022
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.6758 1
Toxoplasma gondii isocitrate dehydrogenase 0.0033 0.0158 0.0173
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0233
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0183 0.0632
Trichomonas vaginalis conserved hypothetical protein 0.0031 0.0134 0.045
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2513 0.3329
Echinococcus granulosus Protein patched homolog 1 0.0048 0.0313 0.0414
Echinococcus granulosus peptidase Clp S14 family 0.0472 0.4878 0.6463
Echinococcus granulosus expressed protein 0.0045 0.0279 0.0369
Trichomonas vaginalis D-aminoacylase, putative 0.0148 0.1397 0.5185
Echinococcus granulosus snurportin 1 0.0326 0.3301 0.4374
Loa Loa (eye worm) hypothetical protein 0.0066 0.0506 0.0669
Trypanosoma brucei target of rapamycin kinase 3, putative 0.0036 0.0183 0.0271
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0061 0.0461 0.0556
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.004 0.0234 0.0322
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.017 0.0224
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Loa Loa (eye worm) hypothetical protein 0.0023 0.0049 0.0063
Echinococcus multilocularis protein patched 0.0048 0.0313 0.0377
Echinococcus granulosus TGF beta signal transducer SmadC 0.0042 0.0249 0.0329
Onchocerca volvulus 0.0034 0.017 0.0629
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.0088
Schistosoma mansoni hypothetical protein 0.0114 0.1025 0.1357
Echinococcus granulosus Niemann Pick C1 protein 0.0111 0.0995 0.1317
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0111 0.0993 0.1448
Trypanosoma cruzi trypanothione reductase, putative 0.0037 0.0194 0.0263
Echinococcus granulosus lysine specific demethylase 6a 0.0021 0.0028 0.0036
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0037 0.0194 0.022
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0061 0.0461 0.061
Echinococcus multilocularis FKBP12 rapamycin complex associated protein 0.0045 0.0281 0.0338
Echinococcus multilocularis Jumonji, AT rich interactive domain 1B 0.0023 0.0047 0.0056
Brugia malayi MH1 domain containing protein 0.0023 0.0049 0.0063
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0037 0.0194 0.0235
Schistosoma mansoni niemann-pick C1 (NPC1) 0.0113 0.1013 0.1342
Onchocerca volvulus 0.0268 0.2681 1
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0037 0.0194 0.0255
Schistosoma mansoni phd/f-box containing protein 0.0021 0.0028 0.0036
Brugia malayi jmjC domain containing protein 0.0021 0.0028 0.0036
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0061 0.0461 0.061
Loa Loa (eye worm) transcription factor SMAD2 0.0612 0.6384 0.8459
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Leishmania major target of rapamycin (TOR) kinase 2, putative 0.0045 0.0281 0.0392
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Brugia malayi nuclear hormone receptor family member nhr-6 0.0029 0.0112 0.0147
Brugia malayi PHD-finger family protein 0.0023 0.005 0.0065
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0112 0.0147
Echinococcus multilocularis cpg binding protein 0.0033 0.0155 0.0186
Trichomonas vaginalis PIKK family atypical protein kinase 0.0045 0.0281 0.1001
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0033 0.0158 0.021
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Echinococcus multilocularis JmjC domain containing protein 4 0.0021 0.0028 0.0033
Brugia malayi orphan nuclear receptor NR2E1 0.0029 0.0112 0.0147
Trypanosoma brucei DNA polymerase IV, putative 0.002 0.0017 0.0025
Echinococcus multilocularis lamin dm0 0.0113 0.1011 0.122
Wolbachia endosymbiont of Brugia malayi ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Leishmania major hypothetical protein, conserved 0.0027 0.0095 0.0115
Echinococcus multilocularis snurportin 1 0.0326 0.3301 0.3986
Schistosoma mansoni mixed-lineage leukemia protein mll 0.003 0.0128 0.0168
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0042 0.0249 0.03
Treponema pallidum ATP-dependent Clp protease proteolytic subunit 0.0248 0.2469 0.3095
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Echinococcus granulosus peregrin 0.0066 0.0506 0.0669
Onchocerca volvulus 0.0113 0.1011 0.377
Echinococcus granulosus Nuclear hormone receptor HR96 0.0029 0.0112 0.0147
Echinococcus granulosus Smad4 0.0042 0.0249 0.0329
Mycobacterium leprae conserved hypothetical protein 0.0148 0.1397 0.1538
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.006 0.0172
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0033 0.0158 0.0208
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.004 0.0234 0.0217
Echinococcus granulosus sterol regulatory element binding protein 0.0048 0.0313 0.0414
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.0083 0.0697 0.0841
Schistosoma mansoni peptidase Clp (S14 family) 0.072 0.7547 1
Loa Loa (eye worm) nuclear hormone receptor-like 1 0.0032 0.015 0.0197
Echinococcus multilocularis thyroid hormone receptor alpha 0.0686 0.7176 0.8667
Entamoeba histolytica hypothetical protein 0.0114 0.1025 1
Trypanosoma brucei PAB1-binding protein , putative 0.0027 0.0095 0.014
Trichomonas vaginalis mercuric reductase, putative 0.0037 0.0194 0.0674
Echinococcus multilocularis dna polymerase kappa 0.002 0.0017 0.0019
Onchocerca volvulus 0.0031 0.0136 0.0502
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0061 0.0461 0.061
Echinococcus granulosus jumonji domain containing 1A 0.0021 0.0028 0.0036
Brugia malayi ecdysteroid receptor 0.0061 0.0461 0.061
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Schistosoma mansoni hypothetical protein 0.0046 0.0295 0.0389
Trypanosoma brucei importin beta-1 subunit, putative 0.003 0.0128 0.019
Echinococcus granulosus Jumonji AT rich interactive domain 1B 0.0023 0.0047 0.0061
Echinococcus multilocularis protein dispatched 1 0.0054 0.0385 0.0464
Schistosoma mansoni hypothetical protein 0.0066 0.0506 0.0669
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0027 0.0089 0.0117
Onchocerca volvulus Alhambra homolog 0.0066 0.0506 0.1883
Echinococcus granulosus geminin 0.019 0.1843 0.2442
Echinococcus multilocularis Smad4 0.0042 0.0249 0.03
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0115
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.002 0.0017 0.0021
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0061 0.0461 0.0556
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Trichomonas vaginalis chromobox protein, putative 0.0047 0.0307 0.1099
Toxoplasma gondii WD domain, G-beta repeat-containing protein 0.0021 0.0031 0.0004
Trypanosoma cruzi Phosphatidylinositol 3-kinase tor2 0.0045 0.0281 0.0392
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0321 0.0386
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1397 0.2047
Schistosoma mansoni ubiquitously transcribed sex (X/Y) chromosome tetratricopeptide repeat protein-related 0.0021 0.0028 0.0036
Brugia malayi CXXC zinc finger family protein 0.0031 0.0136 0.0178
Mycobacterium tuberculosis Conserved hypothetical protein 0.0341 0.3465 0.3454
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0048 0.0321 0.0424
Loa Loa (eye worm) hypothetical protein 0.0034 0.017 0.0224
Brugia malayi Phosphatidylinositol 3- and 4-kinase family protein 0.0045 0.0281 0.0371
Echinococcus multilocularis FTZ F1 alpha 0.0061 0.0461 0.0556
Schistosoma mansoni hypothetical protein 0.0326 0.3301 0.4374
Plasmodium vivax thioredoxin reductase, putative 0.0106 0.0935 0.1207
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Schistosoma mansoni chromobox protein 0.0078 0.064 0.0847
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.017 0.0224
Plasmodium falciparum thioredoxin reductase 0.0037 0.0194 0.022
Schistosoma mansoni nuclear hormone receptor 0.0061 0.0461 0.061
Schistosoma mansoni transcription factor LCR-F1 0.0114 0.1025 0.1357
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.002 0.0017 0.0011
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0148 0.1397 0.185
Echinococcus granulosus expressed conserved protein 0.0104 0.0922 0.1221
Brugia malayi isocitrate dehydrogenase 0.0033 0.0158 0.0208
Echinococcus multilocularis nuclear receptor subfamily 1 group D 0.0032 0.015 0.018
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2513 0.3329
Loa Loa (eye worm) hypothetical protein 0.0023 0.005 0.0065
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.0083 0.0697 0.0923
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0112 0.0147
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Schistosoma mansoni ferritin 0.0045 0.0279 0.0369
Schistosoma mansoni bromodomain-containing nuclear protein 1 brd1 0.0066 0.0506 0.0669
Toxoplasma gondii target of rapamycin (TOR), putative 0.0033 0.0158 0.0172
Schistosoma mansoni hypothetical protein 0.019 0.1843 0.2442
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0158 0.019
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.0248 0.2469 0.3247
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0048 0.0321 0.0424
Onchocerca volvulus 0.0047 0.0307 0.1143
Plasmodium falciparum glutathione reductase 0.0037 0.0194 0.022
Toxoplasma gondii PHD-finger domain-containing protein 0.0021 0.0031 0.0004
Echinococcus granulosus ecdysone induced protein 78C 0.0061 0.0461 0.061
Trypanosoma brucei DNA polymerase beta thumb, putative 0.0091 0.0779 0.1152
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Trypanosoma cruzi GTP-binding nuclear protein rtb2, putative 0.0022 0.0042 0.0037
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0148 0.1397 0.1383
Trypanosoma cruzi mitochondrial DNA polymerase beta, putative 0.0647 0.6758 1
Echinococcus granulosus GTP binding nuclear protein Ran 0.0022 0.0042 0.0054
Onchocerca volvulus 0.0061 0.0461 0.1718
Brugia malayi MH1 domain containing protein 0.0042 0.0249 0.0329
Mycobacterium leprae ATP-dependent Clp protease proteolytic subunit 1 0.0248 0.2469 0.3014
Schistosoma mansoni cpg binding protein 0.0033 0.0155 0.0204
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Loa Loa (eye worm) hypothetical protein 0.0044 0.0271 0.0358
Plasmodium falciparum importin beta, putative 0.003 0.0128 0.0133
Schistosoma mansoni hypothetical protein 0.0021 0.0031 0.004
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0047 0.0307 0.1142
Brugia malayi nuclear receptor RXR 0.0032 0.015 0.0197
Schistosoma mansoni steroid hormone receptor ad4bp 0.0061 0.0461 0.061
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0029 0.0112 0.0134
Loa Loa (eye worm) MH2 domain-containing protein 0.0042 0.0249 0.0329
Loa Loa (eye worm) nuclear factor I 0.0023 0.0049 0.0063
Trichomonas vaginalis PIKK family atypical protein kinase 0.0033 0.0158 0.0539
Loa Loa (eye worm) hypothetical protein 0.0021 0.0028 0.0036
Echinococcus multilocularis chromobox protein 1 0.0078 0.064 0.0772
Echinococcus multilocularis smad 0.0042 0.0249 0.03
Trichomonas vaginalis importin beta-1, putative 0.0025 0.0066 0.0197
Echinococcus multilocularis nuclear receptor subfamily 4 group A 0.0029 0.0112 0.0134
Giardia lamblia GTOR 0.0045 0.0281 0.5401
Schistosoma mansoni tar DNA-binding protein 0.0252 0.2513 0.3329
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0268 0.2678 0.2666
Mycobacterium tuberculosis Probable dehydrogenase 0.0241 0.2389 0.2376
Entamoeba histolytica hypothetical protein 0.0025 0.0066 0.0493
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0047 0.0307 0.0406
Trypanosoma brucei phosphatidylinositol 4-kinase, putative 0.0045 0.0281 0.0415
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.072 0.7547 1
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0234 0.0824
Loa Loa (eye worm) jmjC domain-containing protein 0.0021 0.0028 0.0036
Entamoeba histolytica exodeoxyribonuclease III, putative 0.004 0.0234 0.2153
Onchocerca volvulus Heterochromatin protein 1 homolog 0.0044 0.0271 0.1009
Schistosoma mansoni cpg binding protein 0.0033 0.0155 0.0204
Onchocerca volvulus Nuclear receptor subfamily 6 group A member 1 homolog 0.0029 0.0112 0.0415
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0033 0.0158 0.019
Echinococcus granulosus ferritin 0.0045 0.0279 0.0369
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0255
Schistosoma mansoni hypothetical protein 0.018 0.1738 0.2301
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.0083 0.0697 0.0923
Echinococcus granulosus ATP dependent Clp protease proteolytic subunit 0.072 0.7547 1
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.004 0.0234 0.0346
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0241 0.2389 0.2376
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0033 0.0158 0.0173
Echinococcus granulosus beta LACTamase domain containing family member 0.0148 0.1397 0.185
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0033 0.0158 0.0208
Loa Loa (eye worm) hypothetical protein 0.0111 0.0995 0.1317
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0264 0.2634 0.349
Trichomonas vaginalis PIKK family atypical protein kinase 0.0026 0.0085 0.0265
Echinococcus granulosus lysine specific demethylase 5A 0.0081 0.0673 0.0891
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Loa Loa (eye worm) beta-lactamase 0.0148 0.1397 0.185
Plasmodium vivax importin-beta 2, putative 0.003 0.0128 0.0133
Schistosoma mansoni hypothetical protein 0.0083 0.0697 0.0923
Brugia malayi tailless protein 0.0029 0.0112 0.0147
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0148 0.1397 0.1383
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.002 0.0017 0.0019
Echinococcus multilocularis geminin 0.019 0.1843 0.2226
Schistosoma mansoni ran 0.0022 0.0042 0.0054
Trichomonas vaginalis ap endonuclease, putative 0.004 0.0234 0.0824
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0061 0.0461 0.061
Brugia malayi jmjC domain containing protein 0.0021 0.0028 0.0036
Mycobacterium ulcerans beta-lactamase 0.0148 0.1397 0.1833
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0037 0.0194 0.0263
Brugia malayi RNA, U transporter 1 0.0087 0.0733 0.097
Loa Loa (eye worm) hypothetical protein 0.0027 0.0095 0.0124
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0461 0.061
Trypanosoma brucei trypanothione reductase 0.0106 0.0935 0.1384
Schistosoma mansoni DNA polymerase eta 0.002 0.0017 0.0021
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0061 0.0461 0.061
Giardia lamblia Endonuclease/Exonuclease/phosphatase 0.004 0.0234 0.4439
Plasmodium vivax hypothetical protein, conserved 0.0023 0.0051 0.0031
Schistosoma mansoni protein phosphatase 2C 0.0021 0.0028 0.0036
Wolbachia endosymbiont of Brugia malayi bacterioferritin/cytochrome b1 0.0045 0.0279 0.0116
Mycobacterium ulcerans bacterioferritin BfrA 0.0045 0.0279 0.0348
Brugia malayi TAR-binding protein 0.0252 0.2513 0.3329
Toxoplasma gondii HEAT repeat-containing protein 0.003 0.0128 0.0133
Plasmodium falciparum ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Brugia malayi F/Y-rich N-terminus family protein 0.0032 0.0147 0.0193
Brugia malayi MH2 domain containing protein 0.0042 0.0249 0.0329
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0271 0.0965
Echinococcus multilocularis isocitrate dehydrogenase 0.0033 0.0158 0.019
Plasmodium falciparum glutathione reductase 0.0106 0.0935 0.1207
Brugia malayi nuclear hormone receptor 0.0061 0.0461 0.061
Toxoplasma gondii ATP-dependent Clp endopeptidase, proteolytic subunit ClpP domain-containing protein 0.072 0.7547 1
Brugia malayi Niemann-Pick C1 protein precursor 0.0111 0.0995 0.1317
Loa Loa (eye worm) hypothetical protein 0.0052 0.0363 0.0479
Plasmodium vivax SET domain protein, putative 0.0034 0.017 0.0189
Trypanosoma cruzi target of rapamycin kinase 3 0.0036 0.0183 0.0246
Echinococcus granulosus lamin dm0 0.0113 0.1011 0.1339
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0183 0.0632
Echinococcus granulosus Niemann Pick C1 protein 0.0159 0.1507 0.1996
Trichomonas vaginalis conserved hypothetical protein 0.0044 0.0271 0.0965
Onchocerca volvulus 0.0029 0.0112 0.0415
Echinococcus granulosus thyroid hormone receptor alpha 0.0029 0.0112 0.0147
Brugia malayi MH1 domain containing protein 0.0042 0.0249 0.0329
Loa Loa (eye worm) jmjC domain-containing protein 0.0081 0.0673 0.0891
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.0197
Brugia malayi jmjC domain containing protein 0.0215 0.211 0.2795
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0235 0.2332 0.309
Echinococcus multilocularis ecdysone induced protein 78C 0.0061 0.0461 0.0556
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0252 0.2513 0.3329
Echinococcus granulosus phd:f box containing protein 0.0021 0.0028 0.0036
Leishmania major hypothetical protein, conserved 0.0148 0.1397 0.2047
Brugia malayi AF-10 protein 0.0021 0.0031 0.004
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.004 0.0234 0.0281
Trypanosoma cruzi PAB1-binding protein , putative 0.0027 0.0095 0.0115
Trichomonas vaginalis esterase, putative 0.0148 0.1397 0.5185
Schistosoma mansoni terminal deoxycytidyl transferase 0.002 0.0017 0.0021
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.0095 0.0088
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0037 0.0194 0.022
Echinococcus granulosus intermediate filament protein 0.0113 0.1011 0.1339
Entamoeba histolytica Ran family GTPase 0.0022 0.0042 0.0249
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Trichomonas vaginalis glutathione reductase, putative 0.0037 0.0194 0.0674
Mycobacterium tuberculosis Probable reductase 0.0241 0.2389 0.2376
Leishmania major hypothetical protein, conserved 0.0021 0.0028 0.0017
Loa Loa (eye worm) intermediate filament protein 0.0113 0.1011 0.1339
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0235
Brugia malayi Intermediate filament tail domain containing protein 0.0113 0.1011 0.1339
Leishmania major mitochondrial DNA polymerase beta 0.0647 0.6758 1
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0034 0.017 0.0204
Loa Loa (eye worm) hypothetical protein 0.0264 0.2634 0.349
Loa Loa (eye worm) thioredoxin reductase 0.0106 0.0935 0.1238
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0241 0.2389 0.2376
Chlamydia trachomatis ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Toxoplasma gondii thioredoxin reductase 0.0106 0.0935 0.1207
Echinococcus multilocularis phd:f box containing protein 0.0021 0.0028 0.0033
Mycobacterium ulcerans ATP-dependent Clp protease proteolytic subunit 0.072 0.7547 1
Brugia malayi jmjC domain containing protein 0.0021 0.0028 0.0036
Toxoplasma gondii PHD-finger domain-containing protein 0.0066 0.0506 0.0635
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0061 0.0461 0.061
Trichomonas vaginalis penicillin-binding protein, putative 0.0148 0.1397 0.5185
Brugia malayi jmjC domain containing protein 0.0021 0.0028 0.0036
Brugia malayi nuclear receptor NHR-88 0.0061 0.0461 0.061
Trypanosoma brucei DNA polymerase eta, putative 0.002 0.0017 0.0025
Echinococcus granulosus thioredoxin glutathione reductase 0.0106 0.0935 0.1238
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0061 0.0461 0.061
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0061 0.0461 0.061
Brugia malayi PHD-finger family protein 0.0066 0.0506 0.0669
Brugia malayi nuclear receptor NHR-88 0.0029 0.0112 0.0147
Loa Loa (eye worm) Smad1 0.0042 0.0249 0.0329
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0789 0.828 1
Echinococcus granulosus jumonji domain containing protein 0.0091 0.0782 0.1035
Echinococcus multilocularis cytoplasmic intermediate filament protein 0.0054 0.0385 0.0464
Echinococcus multilocularis peregrin 0.0066 0.0506 0.061
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.0197
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0276
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0061 0.0461 0.1718
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0037 0.0194 0.022
Brugia malayi exodeoxyribonuclease III family protein 0.004 0.0234 0.0308
Mycobacterium tuberculosis Probable ATP-dependent CLP protease proteolytic subunit 1 ClpP1 (endopeptidase CLP) 0.0472 0.4878 0.4869
Brugia malayi hypothetical protein 0.0029 0.0112 0.0147
Mycobacterium ulcerans lipase LipD 0.0148 0.1397 0.1833
Trypanosoma cruzi hypothetical protein, conserved 0.0148 0.1397 0.2047
Trichomonas vaginalis conserved hypothetical protein 0.0048 0.0313 0.1121
Plasmodium falciparum phd finger protein, putative 0.0066 0.0506 0.0635
Toxoplasma gondii LsmAD domain-containing protein 0.0027 0.0095 0.0088
Treponema pallidum exodeoxyribonuclease (exoA) 0.004 0.0234 0.0054
Brugia malayi nuclear receptor NHR-67 0.0029 0.0112 0.0147
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1397 0.185
Plasmodium vivax ATP-dependent Clp protease proteolytic subunit, putative 0.0248 0.2469 0.3247
Treponema pallidum bacterioferrin (TpF1) 0.0045 0.0279 0.0116
Mycobacterium tuberculosis Bacterioferritin BfrB 0.0045 0.0279 0.0263
Trichomonas vaginalis Importin beta-1 subunit, putative 0.0025 0.0066 0.0197
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0148 0.1397 0.185
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0061 0.0461 0.061
Schistosoma mansoni ataxia telangiectasia mutated (atm)-related 0.0045 0.0281 0.0371
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0625 0.6515 0.7868
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0037 0.0194 0.022
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0183 0.0632
Echinococcus multilocularis thioredoxin glutathione reductase 0.0106 0.0935 0.1129
Brugia malayi Nuclear hormone receptor-like 1 0.0061 0.0461 0.061
Echinococcus multilocularis lysine specific demethylase 5A 0.0079 0.0654 0.0789
Entamoeba histolytica Niemann-Pick C1 protein, putative 0.0111 0.0995 0.9702
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0037 0.0194 0.0287
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 1 CLPP1 (ENDOPEPTIDASE CLP) 0.0472 0.4878 0.6328
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.006 0.0172
Plasmodium vivax hypothetical protein, conserved 0.0148 0.1397 0.1821
Loa Loa (eye worm) hypothetical protein 0.0032 0.015 0.0197
Onchocerca volvulus 0.0113 0.1011 0.377
Brugia malayi Importin beta-1 subunit 0.003 0.0128 0.0169
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0048 0.0321 0.0386
Echinococcus granulosus Transcription factor JmjC domain containing protein 0.0215 0.211 0.2795
Brugia malayi nuclear hormone receptor 0.0029 0.0112 0.0147
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0033 0.0158 0.021
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0241 0.2389 0.2376
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0032 0.015 0.0197
Brugia malayi Thioredoxin reductase 0.0106 0.0935 0.1238
Echinococcus multilocularis GPCR, family 2 0.0083 0.0697 0.0841
Echinococcus granulosus nuclear receptor subfamily 4 group A 0.0029 0.0112 0.0147
Trichomonas vaginalis ferritin, putative 0.0045 0.0279 0.0994
Trichomonas vaginalis PIKK family atypical protein kinase 0.0024 0.0059 0.0171
Trichomonas vaginalis ran, putative 0.0022 0.0042 0.0105
Schistosoma mansoni hypothetical protein 0.0625 0.6515 0.8633
Plasmodium vivax GTP-binding nuclear protein RAN/TC4, putative 0.0022 0.0042 0.0018
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0048 0.0321 0.0424
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0037 0.0194 0.0287
Schistosoma mansoni hypothetical protein 0.0083 0.0697 0.0923
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0268 0.2678 0.3301
Mycobacterium ulcerans hypothetical protein 0.0148 0.1397 0.1833
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0461 0.061
Schistosoma mansoni nuclear receptor 0.0029 0.0112 0.0147
Schistosoma mansoni jumonji/arid domain-containing protein 0.0081 0.0673 0.0891
Mycobacterium tuberculosis Conserved protein 0.0148 0.1397 0.1383
Brugia malayi nuclear receptor subfamily 1, group D, member 1, putative 0.0029 0.0112 0.0147
Trichomonas vaginalis PIKK family atypical protein kinase 0.0027 0.0087 0.0276
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0037 0.0194 0.0263
Mycobacterium leprae PROBABLE ATP-DEPENDENT CLP PROTEASE PROTEOLYTIC SUBUNIT 2 CLPP2 (ENDOPEPTIDASE CLP 2) 0.072 0.7547 1
Trichomonas vaginalis PIKK family atypical protein kinase 0.0036 0.0183 0.0632
Mycobacterium ulcerans bacterioferritin BfrB 0.0045 0.0279 0.0348
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.004 0.0234 0.0308
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.018 0.1738 0.2301
Schistosoma mansoni smad1 5 8 and 0.0042 0.0249 0.0329
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.0083 0.0697 0.0923
Brugia malayi Probable ClpP-like protease 0.072 0.7547 1
Toxoplasma gondii exonuclease III APE 0.004 0.0234 0.0274
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Loa Loa (eye worm) nuclear receptor NHR-67 0.0029 0.0112 0.0147
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0061 0.0461 0.061
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0061 0.0461 0.061
Echinococcus multilocularis lamin 0.0113 0.1011 0.122
Entamoeba histolytica hypothetical protein 0.0114 0.1025 1
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0268 0.2678 0.2666
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.0095 0.0088
Schistosoma mansoni hypothetical protein 0.0083 0.0697 0.0923
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Schistosoma mansoni Smad4 0.0042 0.0249 0.0329
Brugia malayi jmjC domain containing protein 0.0081 0.0673 0.0891
Brugia malayi Isocitrate dehydrogenase 0.0033 0.0158 0.0208
Toxoplasma gondii ABC1 family protein 0.0148 0.1397 0.1821
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0034 0.017 0.0224
Brugia malayi Nuclear hormone receptor E75 0.0029 0.0112 0.0147
Trypanosoma cruzi mitochondrial DNA polymerase beta-PAK, putative 0.0091 0.0779 0.113
Schistosoma mansoni hypothetical protein 0.019 0.1843 0.2442
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0114 0.1025 0.1237
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0241 0.2389 0.2903
Plasmodium falciparum conserved Plasmodium membrane protein, unknown function 0.0023 0.0051 0.0031
Brugia malayi hypothetical protein 0.0032 0.015 0.0197
Schistosoma mansoni apoferritin-2 0.0045 0.0279 0.0369
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0034 0.017 0.0204
Brugia malayi RNA recognition motif domain containing protein 0.0252 0.2513 0.3329
Loa Loa (eye worm) hypothetical protein 0.0058 0.0428 0.0566
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0061 0.0461 0.061
Toxoplasma gondii histone lysine methyltransferase SET1 0.006 0.0449 0.0559
Loa Loa (eye worm) MH1 domain-containing protein 0.0042 0.0249 0.0329
Schistosoma mansoni nuclear hormone receptor superfamily protein-related 0.0029 0.0112 0.0147
Trypanosoma brucei hypothetical protein, conserved 0.0148 0.1397 0.2067
Loa Loa (eye worm) hypothetical protein 0.0029 0.0112 0.0147
Schistosoma mansoni ferritin 0.0045 0.0279 0.0369
Loa Loa (eye worm) hypothetical protein 0.0054 0.0385 0.0509
Loa Loa (eye worm) hypothetical protein 0.0061 0.0461 0.061
Schistosoma mansoni nuclear hormone receptor 0.0029 0.0112 0.0147
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.004 0.0234 0.0274
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0033 0.0158 0.0173
Echinococcus granulosus tar DNA binding protein 0.0252 0.2513 0.3329
Leishmania major mitochondrial DNA polymerase beta-PAK, putative 0.0306 0.3093 0.4564
Schistosoma mansoni ferritin light chain 0.0045 0.0279 0.0369
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0061 0.0461 0.061
Loa Loa (eye worm) hypothetical protein 0.0148 0.1397 0.185
Loa Loa (eye worm) GTP-binding nuclear protein RAN/TC4 0.0022 0.0042 0.0054
Echinococcus multilocularis Transcription factor, JmjC domain containing protein 0.0215 0.211 0.2547
Trypanosoma brucei DNA polymerase kappa, putative 0.002 0.0017 0.0025
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0061 0.0461 0.061
Brugia malayi latrophilin 2 splice variant baaae 0.018 0.1738 0.2301
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0061 0.0461 0.061
Brugia malayi hypothetical protein 0.0029 0.0112 0.0147
Giardia lamblia PHD finger protein 15 0.0066 0.0506 1
Schistosoma mansoni hypothetical protein 0.0083 0.0697 0.0923
Brugia malayi Smad1 0.0042 0.0249 0.0329
Schistosoma mansoni smad1 5 8 and 0.0042 0.0249 0.0329

Activities

Activity type Activity value Assay description Source Reference
IC50 (binding) = 47 uM Inhibition of specific binding of 1.5 nM [3H]-diazepam to rat brain benzodiazepine receptors ChEMBL. 1967311
IC50 (binding) = 47 uM Inhibition of specific binding of 1.5 nM [3H]-diazepam to rat brain benzodiazepine receptors ChEMBL. 1967311

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

No external resources registered for this compound

Bibliographic References

1 literature reference was collected for this gene.

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