Detailed information for compound 1009079

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 311.418 | Formula: C20H25NO2
  • H donors: 0 H acceptors: 1 LogP: 4.18 Rotable bonds: 3
    Rule of 5 violations (Lipinski): 1
  • SMILES: CC(=CCCC1(C)CCc2c(O1)c1ccccc1n(c2=O)C)C
  • InChi: 1S/C20H25NO2/c1-14(2)8-7-12-20(3)13-11-16-18(23-20)15-9-5-6-10-17(15)21(4)19(16)22/h5-6,8-10H,7,11-13H2,1-4H3
  • InChiKey: CHEBZMPFNARXFP-UHFFFAOYSA-N  


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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Trypanosoma brucei unspecified product 0.004 0.0413 0.253
Brugia malayi Pre-SET motif family protein 0.0238 0.3456 0.4726
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0402 0.0537
Mycobacterium tuberculosis Fatty-acid-AMP ligase FadD30 (fatty-acid-AMP synthetase) (fatty-acid-AMP synthase) 0.0034 0.0322 0.0895
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD7 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0294 0.0817
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0081 0.0442
Echinococcus multilocularis TGF beta signal transducer SmadC 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD1 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.001 0.0029
Plasmodium falciparum histone acetyltransferase GCN5 0.0043 0.0473 0.1633
Echinococcus multilocularis cadherin EGF LAG seven pass G type receptor 0.005 0.0574 0.0574
Echinococcus granulosus 3 oxoacyl acyl carrier protein synthase 0.0027 0.0215 0.0215
Echinococcus granulosus Smad4 0.0014 0.0025 0.0025
Schistosoma mansoni smad1 5 8 and 0.0014 0.0025 0.0015
Trypanosoma brucei unspecified product 0.004 0.0413 0.253
Trypanosoma cruzi cysteine peptidase, clan CA, family C1, cathepsin L-like, putative 0.0062 0.0759 0.4699
Mycobacterium leprae Probable fructose bisphosphate aldolase Fba 0.0129 0.1775 0.5406
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0609 0.159
Schistosoma mansoni steroid hormone receptor ad4bp 0.0018 0.0078 0.0067
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0023 0.0166 0.0214
Brugia malayi AMP-binding enzyme family protein 0.0112 0.1523 0.2075
Echinococcus granulosus histone acetyltransferase KAT2B 0.0047 0.0534 0.0534
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Trypanosoma cruzi trypanothione reductase, putative 0.0031 0.0283 0.1712
Brugia malayi latrophilin 2 splice variant baaae 0.0108 0.1463 0.1992
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Mycobacterium ulcerans hypothetical protein 0.0045 0.0496 0.1344
Mycobacterium tuberculosis NADPH-dependent mycothiol reductase Mtr 0.009 0.1179 0.3273
Schistosoma mansoni endoplasmin 0.0052 0.0609 0.06
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0402 0.0537
Schistosoma mansoni endoplasmin 0.0052 0.0609 0.06
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0082 0.0098
Loa Loa (eye worm) hypothetical protein 0.0034 0.0322 0.0428
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0609 0.3759
Mycobacterium ulcerans Type I modular polyketide synthase 0.0106 0.1427 0.3866
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0106 0.1427 0.1944
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD35 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0294 0.0817
Brugia malayi Calcitonin receptor-like protein seb-1 0.0158 0.2228 0.3042
Loa Loa (eye worm) Papain cysteine protease/cathepsin propeptide inhibitor-containing protein 0.0018 0.0082 0.0098
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0058 0.0167
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0092
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0041 0.0042
Mycobacterium tuberculosis Possible DNA-damage-inducible protein P DinP (DNA polymerase V) (pol IV 2) (DNA nucleotidyltransferase (DNA-directed)) 0.0057 0.0686 0.1904
Echinococcus granulosus TGF beta signal transducer SmadC 0.0014 0.0025 0.0025
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Mycobacterium ulcerans bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ACP synthetase 0.0013 0.001 0.0028
Trypanosoma cruzi cruzipain precursor, putative 0.0068 0.0849 0.5266
Echinococcus granulosus cadherin EGF LAG seven pass G type receptor 0.005 0.0574 0.0574
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Schistosoma mansoni nuclear hormone receptor 0.0018 0.0078 0.0067
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Mycobacterium tuberculosis Probable membrane NADH dehydrogenase NdhA 0.0204 0.2934 0.8146
Loa Loa (eye worm) hypothetical protein 0.0156 0.2193 0.2994
Toxoplasma gondii heat shock protein HSP90 0.0052 0.0609 0.2114
Giardia lamblia DNA damage repair protein 0.0018 0.0081 0.0104
Loa Loa (eye worm) beta-ketoacyl synthase domain-containing protein 0.0027 0.0215 0.028
Leishmania major apurinic/apyrimidinic endonuclease-redox protein 0.0015 0.0041 0.0194
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Brugia malayi Nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0092
Onchocerca volvulus 0.0018 0.0082 0.0151
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0402 0.2458
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0263 0.3834 1
Onchocerca volvulus 0.0018 0.0082 0.0151
Mycobacterium tuberculosis Probable polyketide synthase Pks7 0.0112 0.1528 0.4243
Mycobacterium tuberculosis Probable chain -fatty-acid-CoA ligase FadD13 (fatty-acyl-CoA synthetase) 0.0045 0.0496 0.1378
Brugia malayi hypothetical protein 0.0481 0.716 0.9806
Trypanosoma cruzi cytosolic leucyl aminopeptidase, putative 0.0117 0.1604 1
Mycobacterium tuberculosis Probable polyketide synthase Pks17 0.0026 0.0204 0.0566
Plasmodium falciparum thioredoxin reductase 0.0031 0.0283 0.0963
Entamoeba histolytica acyl-CoA synthetase, putative 0.0056 0.066 0.1721
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Mycobacterium tuberculosis Probable hydrolase 0.0039 0.0402 0.1117
Echinococcus granulosus DNA apurinic or apyrimidinic site lyase 0.0015 0.0041 0.0041
Plasmodium vivax vivapain-2 0.0018 0.0082 0.0252
Entamoeba histolytica hypothetical protein 0.0072 0.0916 0.2389
Trypanosoma cruzi Heat shock protein 83, putative 0.0052 0.0609 0.3759
Leishmania major DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSA 0.0106 0.1427 0.4348
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0339 0.0329
Echinococcus multilocularis geminin 0.0338 0.4981 0.4981
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Trypanosoma cruzi DNA polymerase eta, putative 0.0047 0.0526 0.3236
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Schistosoma mansoni heat shock protein 0.0052 0.0609 0.06
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0081 0.0442
Trypanosoma cruzi apurinic/apyrimidinic endonuclease, putative 0.0015 0.0041 0.0194
Leishmania major cathepsin L-like protease 0.0068 0.0849 0.5266
Echinococcus granulosus cathepsin l1 0.0018 0.0082 0.0082
Mycobacterium leprae PROBABLE POLYKETIDE BETA-KETOACYL SYNTHASE PKS4 0.0016 0.0057 0.0173
Trypanosoma cruzi apurinic/apyrimidinic endonuclease 0.0015 0.0041 0.0194
Echinococcus multilocularis histone lysine N methyltransferase SETMAR 0.0035 0.0339 0.0339
Schistosoma mansoni hypothetical protein 0.0108 0.1463 0.1454
Mycobacterium tuberculosis Probable polyketide synthase Pks1 0.0076 0.0971 0.2697
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0081 0.0442
Loa Loa (eye worm) glutathione reductase 0.009 0.1179 0.1602
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Loa Loa (eye worm) hypothetical protein 0.0045 0.0496 0.0666
Giardia lamblia NADH oxidase lateral transfer candidate 0.0031 0.0283 0.0638
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0013 0.001 0.0028
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Leishmania major cathepsin L-like protease 0.0068 0.0849 0.5266
Echinococcus multilocularis thyroid hormone receptor alpha 0.0237 0.343 0.343
Wolbachia endosymbiont of Brugia malayi heat shock protein 90 0.0049 0.056 0.3321
Mycobacterium tuberculosis Probable lipase LipD 0.0039 0.0402 0.1117
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Echinococcus granulosus FTZ F1 alpha 0.0018 0.0078 0.0078
Loa Loa (eye worm) isocitrate dehydrogenase 0.0016 0.0058 0.0065
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Schistosoma mansoni aldehyde dehydrogenase 0.0115 0.157 0.1561
Schistosoma mansoni retinoid-x-receptor (RXR) 0.0018 0.0078 0.0067
Mycobacterium tuberculosis Possible fatty-acid-CoA ligase FadD10 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.001 0.0029
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17, putative 0.0117 0.1604 1
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0496 0.1344
Schistosoma mansoni 3-oxoacyl-[ACP] synthase 0.0027 0.0215 0.0205
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0849 0.5266
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Brugia malayi dihydrolipoyl dehydrogenase, mitochondrial precursor, putative 0.0031 0.0283 0.0374
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Plasmodium falciparum isocitrate dehydrogenase [NADP], mitochondrial 0.0016 0.0058 0.0167
Echinococcus multilocularis cpg binding protein 0.0028 0.024 0.024
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0082 0.0213
Schistosoma mansoni cpg binding protein 0.0028 0.024 0.023
Leishmania major DNA damage repair protein, putative 0.0018 0.0081 0.0442
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Probable polyketide synthase Pks5 0.0103 0.1378 0.3825
Toxoplasma gondii 3-oxoacyl-acyl-carrier protein synthase I/II, putative 0.0027 0.0215 0.0721
Plasmodium vivax heat shock protein 86, putative 0.0052 0.0609 0.2114
Mycobacterium ulcerans phenyloxazoline synthase MbtB 0.0024 0.0174 0.0471
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0112 0.1528 0.4138
Leishmania major hypothetical protein, conserved 0.0039 0.0402 0.2458
Onchocerca volvulus 0.0112 0.1523 0.3209
Loa Loa (eye worm) MH1 domain-containing protein 0.0014 0.0025 0.002
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0092
Brugia malayi TAR-binding protein 0.0068 0.0853 0.1156
Leishmania major DNA polymerase eta, putative 0.0047 0.0526 0.3236
Schistosoma mansoni hypothetical protein 0.005 0.0574 0.0564
Echinococcus granulosus cpg binding protein 0.0028 0.024 0.024
Toxoplasma gondii heat shock protein 90, putative 0.0052 0.0609 0.2114
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Plasmodium vivax isocitrate dehydrogenase [NADP], mitochondrial, putative 0.0016 0.0058 0.0167
Toxoplasma gondii exonuclease III APE 0.0015 0.0041 0.0109
Brugia malayi MH1 domain containing protein 0.0014 0.0025 0.002
Brugia malayi heat shock protein 90 0.0052 0.0609 0.0822
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0166 0.0166
Brugia malayi ecdysteroid receptor 0.0018 0.0078 0.0092
Loa Loa (eye worm) ImpB/MucB/SamB family protein 0.0057 0.0686 0.0926
Echinococcus multilocularis DNA (apurinic or apyrimidinic site) lyase 0.0015 0.0041 0.0041
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Brugia malayi hypothetical protein 0.0156 0.2193 0.2994
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Brugia malayi Pyridine nucleotide-disulphide oxidoreductase, dimerisation domain containing protein 0.0023 0.0157 0.0201
Echinococcus granulosus heat shock protein 0.0052 0.0609 0.0609
Echinococcus granulosus GPCR family 2 0.005 0.0574 0.0574
Loa Loa (eye worm) pre-SET domain-containing protein family protein 0.0238 0.3456 0.4726
Echinococcus multilocularis cysteine protease 0.0018 0.0082 0.0082
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0082 0.0151
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0686 0.1857
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtF 0.0024 0.0174 0.0471
Schistosoma mansoni dihydrolipoamide dehydrogenase 0.0031 0.0283 0.0273
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Trichomonas vaginalis mercuric reductase, putative 0.0031 0.0283 0.0374
Trichomonas vaginalis heat shock protein, putative 0.003 0.0274 0.0362
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0447
Mycobacterium tuberculosis Probable soluble pyridine nucleotide transhydrogenase SthA (STH) (NAD(P)(+) transhydrogenase [B-specific]) (nicotinamide nucleot 0.0031 0.0283 0.0786
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Toxoplasma gondii type I fatty acid synthase, putative 0.0114 0.1556 0.5454
Brugia malayi MH1 domain containing protein 0.0014 0.0025 0.002
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0027 0.0215 0.0582
Plasmodium vivax SET domain protein, putative 0.0035 0.0339 0.116
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Echinococcus multilocularis mothers against decapentaplegic 5 0.0014 0.0025 0.0025
Schistosoma mansoni thyroid hormone receptor 0.0237 0.343 0.3423
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSE 0.007 0.0879 0.2678
Loa Loa (eye worm) hypothetical protein 0.0045 0.049 0.0657
Schistosoma mansoni ap endonuclease 0.0015 0.0041 0.0031
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0283 0.1712
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Plasmodium vivax acyl-CoA synthetase, putative 0.0034 0.0322 0.1101
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1333 0.1324
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Trypanosoma brucei DNA polymerase eta, putative 0.0086 0.1131 0.7033
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0016 0.0057 0.0158
Leishmania major beta-ketoacyl synthase family protein, putative,3-oxoacyl-acyl carrier protein synthase ii, putative 0.0027 0.0215 0.1283
Mycobacterium leprae PROBABLE THIOESTERASE TESA 0.0088 0.1157 0.3526
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Echinococcus granulosus ecdysone induced protein 78C 0.0018 0.0078 0.0078
Mycobacterium tuberculosis Probable polyketide synthase Pks8 0.0087 0.1132 0.3144
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Trichomonas vaginalis DNA polymerase eta, putative 0.0057 0.0686 0.0926
Trypanosoma brucei hypothetical protein, conserved 0.0039 0.0402 0.2458
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1333 0.1324
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Schistosoma mansoni glutaminase 0.0254 0.3692 0.3686
Trypanosoma brucei hypothetical protein, conserved 0.0018 0.0081 0.0442
Toxoplasma gondii NADPH-glutathione reductase 0.0031 0.0283 0.0963
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.007 0.0879 0.2381
Mycobacterium tuberculosis Bifunctional enzyme MbtA: salicyl-AMP ligase (SAL-AMP ligase) + salicyl-S-ArCP synthetase 0.0013 0.001 0.0029
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Schistosoma mansoni hypothetical protein 0.005 0.0574 0.0564
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0092
Mycobacterium ulcerans Type I modular polyketide synthase 0.0106 0.1427 0.3866
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Loa Loa (eye worm) latrophilin receptor protein 2 0.005 0.0574 0.0773
Echinococcus multilocularis leucine aminopeptidase protein 0.0117 0.1604 0.1604
Trichomonas vaginalis penicillin-binding protein, putative 0.0039 0.0402 0.0537
Brugia malayi ImpB/MucB/SamB family protein 0.0086 0.1131 0.1537
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Plasmodium falciparum conserved Plasmodium protein, unknown function 0.0015 0.004 0.0106
Onchocerca volvulus 0.0035 0.0339 0.0698
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Loa Loa (eye worm) hypothetical protein 0.0059 0.0715 0.0967
Brugia malayi isocitrate dehydrogenase 0.0016 0.0058 0.0065
Mycobacterium ulcerans beta-lactamase 0.0039 0.0402 0.1089
Toxoplasma gondii heat shock protein 75, putative 0.0035 0.0341 0.1165
Brugia malayi Nuclear hormone receptor family member nhr-19 0.0018 0.0078 0.0092
Mycobacterium tuberculosis Probable fructose-bisphosphate aldolase Fba 0.0129 0.1775 0.4928
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD7 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0496 0.1512
Trichomonas vaginalis set domain proteins, putative 0.0271 0.3958 0.5415
Giardia lamblia Grp94/Hsp90 0.0049 0.056 0.1368
Mycobacterium ulcerans multifunctional mycocerosic acid synthase membrane-associated Mas 0.0112 0.1528 0.4138
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0853 0.0843
Entamoeba histolytica fructose-1,6-bisphosphate aldolase, putative 0.0263 0.3834 1
Schistosoma mansoni survival motor neuron protein 0.0098 0.1308 0.1299
Mycobacterium ulcerans hypothetical protein 0.0039 0.0402 0.1089
Mycobacterium ulcerans esterase/lipase LipP 0.0039 0.0402 0.1089
Trypanosoma cruzi cysteine peptidase, putative 0.0018 0.0082 0.0447
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks4 0.0016 0.0057 0.0158
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0686 0.4239
Brugia malayi Nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0092
Onchocerca volvulus 0.0018 0.0082 0.0151
Toxoplasma gondii histone lysine acetyltransferase GCN5-B 0.0047 0.0534 0.1846
Brugia malayi Hypothetical 52.5 kDa protein ZK945.1 in chromosome II, putative 0.0039 0.0402 0.0537
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.01 0.1333 0.1814
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0339 0.0329
Mycobacterium ulcerans long-chain-acyl-CoA synthetase 0.0013 0.001 0.0028
Brugia malayi Nuclear hormone receptor family member nhr-25 0.0018 0.0078 0.0092
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0081 0.0442
Loa Loa (eye worm) hypothetical protein 0.0108 0.1463 0.1992
Toxoplasma gondii thioredoxin reductase 0.009 0.1179 0.4122
Echinococcus granulosus 5'partial|histone lysine N methyltransferase SETDB2 0.0033 0.0311 0.0311
Schistosoma mansoni smad1 5 8 and 0.0014 0.0025 0.0015
Brugia malayi Aminopeptidase ZK353.6 in chromosome III 0.0023 0.0166 0.0214
Brugia malayi Nuclear hormone receptor-like 1 0.0018 0.0078 0.0092
Brugia malayi glutaminase DH11.1 0.0254 0.3692 0.5051
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0402 0.0392
Onchocerca volvulus Steroid hormone receptor family member cnr14 homolog 0.0018 0.0078 0.0142
Echinococcus multilocularis cysteine protease 0.0018 0.0082 0.0082
Echinococcus granulosus dna polymerase kappa 0.0057 0.0686 0.0686
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Trypanosoma brucei DNA polymerase kappa, putative 0.0018 0.0081 0.0442
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0496 0.3049
Toxoplasma gondii histone lysine acetyltransferase GCN5-A 0.0047 0.0534 0.1846
Giardia lamblia Methyltransferase like 2 0.0032 0.0296 0.0672
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Echinococcus multilocularis ecdysone induced protein 78C 0.0018 0.0078 0.0078
Onchocerca volvulus 0.0024 0.0174 0.0347
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0027 0.0215 0.1283
Loa Loa (eye worm) hypothetical protein 0.0034 0.0322 0.0428
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Onchocerca volvulus Cathepsin F homolog 0.0018 0.0082 0.0151
Mycobacterium leprae POSSIBLE FATTY-ACID-CoA LIGASE FADD10 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0013 0.001 0.0032
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0496 0.1344
Schistosoma mansoni thyroid hormone receptor 0.0237 0.343 0.3423
Brugia malayi Pre-SET motif family protein 0.0035 0.0339 0.0451
Entamoeba histolytica acyl-CoA synthetase, putative 0.0045 0.0496 0.1294
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0068 0.0853 0.1156
Entamoeba histolytica cysteine protease, putative 0.0018 0.0082 0.0213
Onchocerca volvulus 0.0018 0.0082 0.0151
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0447
Trichomonas vaginalis ap endonuclease, putative 0.0015 0.0041 0.0042
Schistosoma mansoni TGF-beta signal transducer Smad2 0.0014 0.0025 0.0015
Plasmodium falciparum heat shock protein 90, putative 0.003 0.0274 0.093
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Plasmodium falciparum 3-oxoacyl-acyl-carrier protein synthase I/II 0.0027 0.0215 0.0721
Echinococcus multilocularis GPCR, family 2 0.005 0.0574 0.0574
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0082 0.0082
Loa Loa (eye worm) glutaminase 2 0.0254 0.3692 0.5051
Plasmodium falciparum cysteine proteinase falcipain 2b 0.0018 0.0082 0.0252
Brugia malayi Latrophilin receptor protein 2 0.005 0.0574 0.0773
Mycobacterium ulcerans DNA polymerase IV 0.0057 0.0686 0.1857
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.01 0.1333 0.1324
Mycobacterium tuberculosis Polyketide synthetase MbtD (polyketide synthase) 0.0033 0.0306 0.085
Mycobacterium ulcerans polyketide synthase MbtD 0.0033 0.0306 0.0829
Plasmodium falciparum acyl-CoA synthetase 0.0034 0.0322 0.1101
Toxoplasma gondii pyruvate dehydrogenase complex subunit PDH-E3II 0.0031 0.0283 0.0963
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.01 0.1333 0.1814
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0496 0.3049
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Trichomonas vaginalis glutathione reductase, putative 0.0031 0.0283 0.0374
Mycobacterium leprae Probable fatty-acid-CoA synthetase FadD22 (fatty-acid-CoA ligase) (fatty-acid-CoA synthase) 0.0024 0.0174 0.053
Brugia malayi Nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0092
Trypanosoma brucei chrX additional, unordered contigs 0.0018 0.0081 0.0442
Brugia malayi polk-prov protein 0.0018 0.0081 0.0097
Leishmania major trypanothione reductase 0.009 0.1179 0.7331
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0082 0.0071
Brugia malayi CXXC zinc finger family protein 0.0027 0.0216 0.0283
Echinococcus multilocularis isocitrate dehydrogenase 2 (NADP+) 0.0016 0.0058 0.0058
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0849 0.5266
Mycobacterium tuberculosis Probable chaperone protein HtpG (heat shock protein) (HSP90 family protein) (high temperature protein G) 0.0049 0.056 0.1556
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsC 0.0106 0.1427 0.3963
Mycobacterium leprae POSSIBLE O-SUCCINYLBENZOIC ACID--CoA LIGASE MENE (OSB-CoA SYNTHETASE) (O-SUCCINYLBENZOATE-CoA SYNTHASE) 0.0013 0.001 0.0032
Brugia malayi MH2 domain containing protein 0.0014 0.0025 0.002
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Brugia malayi Methyltransferase-like protein 4 0.0032 0.0296 0.0392
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD2 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0045 0.0496 0.1378
Trichomonas vaginalis heat shock protein, putative 0.0038 0.039 0.052
Plasmodium vivax AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0041 0.0109
Schistosoma mansoni hypothetical protein 0.0338 0.4981 0.4976
Schistosoma mansoni heat shock protein 0.0035 0.0341 0.0331
Brugia malayi beta-lactamase 0.0039 0.0402 0.0537
Mycobacterium tuberculosis Possible penicillin-binding protein 0.0248 0.3601 1
Onchocerca volvulus Heat shock protein 75 kDa, mitochondrial homolog 0.0035 0.0341 0.07
Echinococcus granulosus dihydrolipoamide dehydrogenase 0.0031 0.0283 0.0283
Echinococcus granulosus ankyrin repeat domain containing protein 17 0.0023 0.0166 0.0166
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.4989 0.6829
Plasmodium falciparum DNA repair protein REV1, putative 0.0018 0.0081 0.0248
Leishmania major lipophosphoglycan biosynthetic protein, putative,heat shock protein 90, putative,glucose regulated protein 94, putative 0.0049 0.056 0.3451
Chlamydia trachomatis dihydrolipoyl dehydrogenase 0.0031 0.0283 0.0493
Loa Loa (eye worm) ctsf protein 0.0018 0.0082 0.0098
Echinococcus granulosus retinoic acid receptor rxr beta a 0.0018 0.0078 0.0078
Mycobacterium tuberculosis Probable polyketide synthase Pks9 0.006 0.0729 0.2024
Brugia malayi Isocitrate dehydrogenase 0.0016 0.0058 0.0065
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Trypanosoma cruzi isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0297
Echinococcus multilocularis histone lysine methyltransferase setb histone lysine methyltransferase eggless 0.0035 0.0339 0.0339
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Mycobacterium tuberculosis Probable multifunctional mycocerosic acid synthase membrane-associated Mas 0.0112 0.1528 0.4243
Echinococcus granulosus leucine aminopeptidase protein 0.0117 0.1604 0.1604
Plasmodium vivax DNA repair protein REV1, putative 0.0018 0.0081 0.0248
Echinococcus multilocularis terminal deoxycytidyl transferase rev1 0.0057 0.0686 0.0686
Schistosoma mansoni nuclear hormone receptor nor-1/nor-2 0.0018 0.0078 0.0067
Entamoeba histolytica hypothetical protein 0.0072 0.0916 0.2389
Echinococcus granulosus mothers against decapentaplegic 5 0.0014 0.0025 0.0025
Trichomonas vaginalis glucosylceramidase, putative 0.0339 0.4989 0.6829
Trypanosoma cruzi DNA polymerase eta, putative 0.0086 0.1131 0.7033
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0166 0.0166
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Plasmodium vivax hypothetical protein, conserved 0.0039 0.0402 0.1382
Mycobacterium ulcerans long-chain fatty-acid CoA ligase 0.0045 0.0496 0.1344
Trichomonas vaginalis esterase, putative 0.0039 0.0402 0.0537
Echinococcus multilocularis heat shock protein 90 0.0045 0.0494 0.0494
Trypanosoma cruzi beta-ketoacyl synthase family protein, putative 0.0027 0.0215 0.1283
Mycobacterium tuberculosis Polyketide synthase Pks12 0.0112 0.1528 0.4243
Leishmania major dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0447
Schistosoma mansoni histone-lysine n-methyltransferase setb1 0.0035 0.0339 0.0329
Loa Loa (eye worm) hypothetical protein 0.0018 0.0082 0.0098
Plasmodium vivax dihydrolipoyl dehydrogenase, apicoplast, putative 0.0031 0.0283 0.0963
Brugia malayi Nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0092
Loa Loa (eye worm) papain family cysteine protease containing protein 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Probable oxidoreductase 0.0227 0.3283 0.9115
Trypanosoma cruzi major cysteine proteinase, putative 0.0053 0.0627 0.3867
Mycobacterium tuberculosis Hypothetical protein 0.0032 0.0296 0.0822
Onchocerca volvulus Cathepsin L homolog 0.0018 0.0082 0.0151
Mycobacterium ulcerans exodeoxyribonuclease III protein XthA 0.0015 0.0041 0.0112
Toxoplasma gondii histone lysine methyltransferase SET/SUV39 0.0035 0.0339 0.116
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0609 0.3759
Brugia malayi Iron-sulfur cluster assembly accessory protein 0.0098 0.1308 0.178
Chlamydia trachomatis acylglycerophosphoethanolamine acyltransferase 0.0034 0.0322 0.0775
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0402 0.0537
Schistosoma mansoni mixed-lineage leukemia protein mll 0.0058 0.0693 0.0683
Trypanosoma brucei isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0297
Trichomonas vaginalis D-aminoacylase, putative 0.0039 0.0402 0.0537
Schistosoma mansoni coup transcription factor 0.0018 0.0078 0.0067
Loa Loa (eye worm) steroid hormone receptor 0.0018 0.0078 0.0092
Plasmodium falciparum thioredoxin reductase 0.009 0.1179 0.4122
Mycobacterium tuberculosis Probable esterase LipL 0.0039 0.0402 0.1117
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Echinococcus granulosus histone lysine methyltransferase setb 0.0035 0.0339 0.0339
Mycobacterium leprae Probable polyketide synthase Pks1 0.0112 0.1528 0.4654
Echinococcus multilocularis endoplasmin 0.0049 0.056 0.056
Echinococcus multilocularis Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0078
Loa Loa (eye worm) transcription factor SMAD2 0.0208 0.2987 0.4083
Loa Loa (eye worm) thioredoxin reductase 0.009 0.1179 0.1602
Mycobacterium leprae conserved hypothetical protein 0.0039 0.0402 0.1225
Mycobacterium tuberculosis Conserved protein 0.0039 0.0402 0.1117
Plasmodium falciparum cysteine proteinase falcipain 3 0.0018 0.0082 0.0252
Echinococcus multilocularis thioredoxin glutathione reductase 0.009 0.1179 0.1179
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1333 0.1333
Mycobacterium ulcerans thioesterase TesA 0.0088 0.1157 0.3135
Schistosoma mansoni aldehyde dehydrogenase 0.0115 0.157 0.1561
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Toxoplasma gondii BRCA1 C Terminus (BRCT) domain-containing protein 0.0018 0.0081 0.0248
Mycobacterium ulcerans polyketide synthase 0.0112 0.1528 0.4138
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Echinococcus granulosus heat shock protein 90 0.0052 0.0609 0.0609
Loa Loa (eye worm) nuclear hormone receptor family member nhr-1 0.0018 0.0078 0.0092
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Echinococcus multilocularis heat shock protein 0.0052 0.0609 0.0609
Schistosoma mansoni terminal deoxycytidyl transferase 0.0057 0.0686 0.0676
Toxoplasma gondii Hsp90 domain-containing protein 0.0198 0.2844 1
Plasmodium falciparum heat shock protein 90 0.0052 0.0609 0.2114
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0853 0.0843
Leishmania major cytosolic leucyl aminopeptidase,metallo-peptidase, Clan MF, Family M17 0.0117 0.1604 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0115 0.157 0.4252
Echinococcus multilocularis tumor protein p63 0.0304 0.4462 0.4462
Onchocerca volvulus 0.0271 0.3958 0.8375
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD8 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.001 0.0029
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Schistosoma mansoni nuclear receptor 2DBD-gamma 0.0018 0.0078 0.0067
Giardia lamblia DINP protein human, muc B family 0.0057 0.0686 0.1699
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0106 0.1427 0.3963
Mycobacterium ulcerans fusion of enoyl-CoA hydratase, EchA21 and lipase, LipE 0.0039 0.0402 0.1089
Brugia malayi ImpB/MucB/SamB family protein 0.0057 0.0686 0.0926
Mycobacterium tuberculosis Possible conserved lipoprotein LpqK 0.0039 0.0402 0.1117
Mycobacterium ulcerans peptide synthetase Nrp (peptide synthase) 0.0024 0.0174 0.0471
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Loa Loa (eye worm) nuclear hormone receptor family member nhr-14 0.0018 0.0078 0.0092
Wolbachia endosymbiont of Brugia malayi leucyl aminopeptidase 0.0117 0.1604 1
Brugia malayi Corticotropin releasing factor receptor 2 precursor, putative 0.0158 0.2228 0.3042
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsA 0.0085 0.1111 0.3009
Schistosoma mansoni retinoic acid receptor RXR 0.0018 0.0078 0.0067
Loa Loa (eye worm) AMP-binding enzyme family protein 0.0112 0.1523 0.2075
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsE 0.0016 0.0057 0.0158
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Brugia malayi MH2 domain containing protein 0.0014 0.0025 0.002
Loa Loa (eye worm) endoplasmin 0.0052 0.0609 0.0822
Leishmania major 4-coumarate:coa ligase-like protein 0.0045 0.0496 0.3049
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Onchocerca volvulus 0.0027 0.0216 0.0437
Mycobacterium ulcerans non-ribosomal peptide synthetase MbtE 0.0024 0.0174 0.0471
Plasmodium vivax 3-oxoacyl-[acyl-carrier-protein] synthase i/ii, putative 0.0027 0.0215 0.0721
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Leishmania major DNA polymerase eta, putative 0.0086 0.1131 0.7033
Trypanosoma cruzi heat shock protein 85, putative 0.0045 0.0494 0.3033
Echinococcus multilocularis COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0078
Entamoeba histolytica cysteine proteinase, putative 0.0018 0.0082 0.0213
Entamoeba histolytica acetyltransferase, GNAT family 0.0043 0.0473 0.1234
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Plasmodium vivax thioredoxin reductase, putative 0.009 0.1179 0.4122
Trichomonas vaginalis glutaminase, putative 0.0254 0.3692 0.5051
Brugia malayi nuclear receptor NHR-88 0.0018 0.0078 0.0092
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Brugia malayi oxidoreductase, zinc-binding dehydrogenase family protein 0.0201 0.2877 0.3932
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0034 0.0322 0.0873
Loa Loa (eye worm) hypothetical protein 0.0034 0.0322 0.0428
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0115 0.157 0.157
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Echinococcus multilocularis gcn5proteinral control of amino acid synthesis 0.0161 0.2274 0.2274
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0018 0.0081 0.0248
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.253
Plasmodium vivax M17 leucyl aminopeptidase, putative 0.0117 0.1604 0.5623
Onchocerca volvulus Bile acid receptor homolog 0.0018 0.0078 0.0142
Echinococcus granulosus acetyl coenzyme A synthetase cytoplasmic 0.0013 0.001 0.001
Brugia malayi RNA recognition motif domain containing protein 0.0068 0.0853 0.1156
Echinococcus multilocularis smad 0.0014 0.0025 0.0025
Echinococcus multilocularis 3 oxoacyl (acyl carrier protein) synthase 0.0027 0.0215 0.0215
Mycobacterium ulcerans fructose-bisphosphate aldolase 0.0129 0.1775 0.4807
Echinococcus multilocularis dihydrolipoamide dehydrogenase 0.0031 0.0283 0.0283
Schistosoma mansoni hypothetical protein 0.0072 0.0916 0.0907
Mycobacterium tuberculosis Peptide synthetase MbtE (peptide synthase) 0.0024 0.0174 0.0483
Mycobacterium ulcerans aldehyde dehydrogenase 0.0115 0.157 0.4252
Leishmania major DNA polymerase kappa, putative,DNA polymerase IV, putative 0.0057 0.0686 0.4239
Mycobacterium tuberculosis Probable thioesterase TesA 0.0088 0.1157 0.3214
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0081 0.0442
Entamoeba histolytica exodeoxyribonuclease III, putative 0.0015 0.0041 0.0108
Mycobacterium ulcerans acetyl-CoA synthetase 0.0013 0.001 0.0028
Toxoplasma gondii histone lysine methyltransferase SET1 0.0056 0.0661 0.2296
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Brugia malayi Papain family cysteine protease containing protein 0.0018 0.0082 0.0098
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0082 0.0082
Mycobacterium tuberculosis Conserved protein 0.0039 0.0402 0.1117
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSB 0.0085 0.1111 0.3384
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Loa Loa (eye worm) O-glycosyl hydrolase family 30 protein 0.049 0.7301 1
Plasmodium falciparum dihydrolipoyl dehydrogenase, apicoplast 0.0031 0.0283 0.0963
Echinococcus granulosus nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0496 0.0666
Echinococcus granulosus Nuclear hormone receptor family member nhr 41 0.0018 0.0078 0.0078
Plasmodium vivax histone acetyltransferase GCN5, putative 0.0047 0.0534 0.1846
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Mycobacterium ulcerans heat shock protein 90 0.0049 0.056 0.1517
Echinococcus granulosus Mitotic checkpoint protein PRCC C terminal 0.0219 0.316 0.316
Mycobacterium tuberculosis Probable isocitrate dehydrogenase [NADP] Icd1 (oxalosuccinate decarboxylase) (IDH) (NADP+-specific ICDH) (IDP) 0.0016 0.0058 0.016
Trypanosoma brucei dihydrolipoyl dehydrogenase 0.0031 0.0283 0.1712
Plasmodium vivax endoplasmin, putative 0.0052 0.0609 0.2114
Mycobacterium ulcerans acyl-CoA synthetase 0.0045 0.0496 0.1344
Brugia malayi MH2 domain containing protein 0.0208 0.2987 0.4083
Loa Loa (eye worm) nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0092
Schistosoma mansoni DNA polymerase eta 0.0086 0.1131 0.1122
Trichomonas vaginalis Clan CA, family C1, cathepsin L or K-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Probable fatty acid synthase Fas (fatty acid synthetase) 0.0033 0.0317 0.088
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0115 0.157 0.4359
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0447
Echinococcus granulosus geminin 0.0338 0.4981 0.4981
Onchocerca volvulus 0.0018 0.0082 0.0151
Echinococcus granulosus NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Schistosoma mansoni heat shock protein 0.0052 0.0609 0.06
Mycobacterium ulcerans 3-oxoacyl-(acyl carrier protein) synthase II 0.0027 0.0215 0.0582
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0496 0.0666
Echinococcus multilocularis FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0078
Trichomonas vaginalis conserved hypothetical protein 0.0032 0.0296 0.0392
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium ulcerans long-chain-fatty-acid-CoA ligase 0.0045 0.0496 0.1344
Mycobacterium leprae PROBABLE FATTY ACID SYNTHASE FAS (FATTY ACID SYNTHETASE) 0.0033 0.0317 0.0966
Plasmodium vivax hypothetical protein, conserved 0.0015 0.004 0.0106
Leishmania major acetoin dehydrogenase e3 component-like protein 0.0031 0.0283 0.1712
Loa Loa (eye worm) hypothetical protein 0.0018 0.0081 0.0097
Loa Loa (eye worm) hypothetical protein 0.0045 0.0496 0.0666
Mycobacterium tuberculosis Probable exodeoxyribonuclease III protein XthA (exonuclease III) (EXO III) (AP endonuclease VI) 0.0015 0.0041 0.0115
Echinococcus multilocularis diuretic hormone 44 receptor GPRdih2 0.005 0.0574 0.0574
Echinococcus multilocularis FTZ F1 alpha 0.0018 0.0078 0.0078
Loa Loa (eye worm) nuclear Hormone Receptor family member 0.0018 0.0078 0.0092
Trypanosoma brucei dihydrolipoamide dehydrogenase 0.0031 0.0283 0.1712
Plasmodium falciparum heat shock protein 90, putative 0.0198 0.2844 1
Brugia malayi Nuclear hormone receptor family member nhr-3 0.0018 0.0078 0.0092
Schistosoma mansoni hypothetical protein 0.005 0.0574 0.0564
Schistosoma mansoni hypothetical protein 0.038 0.562 0.5615
Trichomonas vaginalis heat shock protein, putative 0.0049 0.056 0.0754
Trypanosoma brucei isocitrate dehydrogenase, putative 0.0016 0.0058 0.0297
Brugia malayi photoreceptor-specific nuclear receptor 0.0018 0.0078 0.0092
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0283 0.1548
Echinococcus multilocularis isocitrate dehydrogenase 0.0016 0.0058 0.0058
Toxoplasma gondii type I fatty acid synthase 0.0016 0.0057 0.0164
Treponema pallidum heat shock protein 90 0.0049 0.056 0.1368
Echinococcus multilocularis Mitotic checkpoint protein PRCC, C terminal 0.0219 0.316 0.316
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Trichomonas vaginalis endoplasmin, putative 0.0038 0.039 0.052
Mycobacterium tuberculosis Probable membrane bound polyketide synthase Pks6 0.0158 0.2228 0.6187
Echinococcus granulosus Basic leucine zipper bZIP transcription 0.0072 0.0916 0.0916
Echinococcus multilocularis microtubule associated protein 2 0.0666 1 1
Leishmania major cathepsin L-like protease 0.0018 0.0082 0.0447
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.253
Trypanosoma brucei DNA polymerase kappa, putative 0.004 0.0413 0.253
Trypanosoma brucei beta-ketoacyl-ACP synthase 0.0027 0.0215 0.1283
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD5 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0294 0.0817
Echinococcus granulosus heat shock protein heat shock protein 90 alpha 0.0045 0.0494 0.0494
Mycobacterium tuberculosis Probable fatty-acid-CoA ligase FadD3 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0032 0.0294 0.0817
Echinococcus granulosus endoplasmin 0.0049 0.056 0.056
Loa Loa (eye worm) beta-LACTamase domain containing family member 0.0039 0.0402 0.0537
Treponema pallidum fructose-bisphosphate aldolase 0.0263 0.3834 1
Echinococcus granulosus diuretic hormone 44 receptor GPRdih2 0.005 0.0574 0.0574
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Loa Loa (eye worm) hypothetical protein 0.0035 0.0339 0.0451
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Trichomonas vaginalis cat eye syndrome critical region protein 2, cscr2, putative 0.0047 0.0534 0.0718
Echinococcus granulosus COUP TF:Svp nuclear hormone receptor 0.0018 0.0078 0.0078
Trypanosoma cruzi heat shock protein 90, putative 0.0052 0.0609 0.3759
Schistosoma mansoni smad1 5 8 and 0.0014 0.0025 0.0015
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0115 0.157 0.157
Treponema pallidum NADH oxidase 0.0031 0.0283 0.0638
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Plasmodium vivax vivapain-2 0.0018 0.0082 0.0252
Brugia malayi Hsp90 protein 0.0035 0.0341 0.0453
Mycobacterium tuberculosis Peptide synthetase MbtF (peptide synthase) 0.0024 0.0174 0.0483
Mycobacterium tuberculosis Probable esterase/lipase LipP 0.0039 0.0402 0.1117
Giardia lamblia Heat shock protein HSP 90-alpha 0.0052 0.0609 0.1498
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Giardia lamblia Fructose-bisphosphate aldolase 0.0263 0.3834 1
Echinococcus granulosus thioredoxin glutathione reductase 0.009 0.1179 0.1179
Loa Loa (eye worm) MH2 domain-containing protein 0.0014 0.0025 0.002
Mycobacterium ulcerans polyketide synthase MbtC 0.0027 0.0215 0.0582
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Mycobacterium ulcerans O-succinylbenzoic acid--CoA ligase 0.0013 0.001 0.0028
Mycobacterium tuberculosis Dihydrolipoamide dehydrogenase LpdC (lipoamide reductase (NADH)) (lipoyl dehydrogenase) (dihydrolipoyl dehydrogenase) (diaphoras 0.0227 0.3283 0.9115
Mycobacterium ulcerans dihydrolipoamide dehydrogenase 0.0031 0.0283 0.0767
Trypanosoma cruzi isocitrate dehydrogenase, putative 0.0016 0.0058 0.0297
Brugia malayi Nuclear hormone receptor family member nhr-40 0.0018 0.0078 0.0092
Entamoeba histolytica hypothetical protein 0.0072 0.0916 0.2389
Echinococcus multilocularis acetyl coenzyme A synthetase, cytoplasmic 0.0013 0.001 0.001
Wolbachia endosymbiont of Brugia malayi dihydrolipoamide dehydrogenase E3 component 0.0031 0.0283 0.1548
Echinococcus granulosus hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0078
Mycobacterium tuberculosis Conserved protein 0.0039 0.0402 0.1117
Toxoplasma gondii ImpB/MucB/SamB family protein 0.0047 0.0526 0.182
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0853 0.0843
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Mycobacterium tuberculosis Phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0106 0.1427 0.3963
Plasmodium falciparum M17 leucyl aminopeptidase 0.0117 0.1604 0.5623
Echinococcus granulosus dna polymerase eta 0.0086 0.1131 0.1131
Brugia malayi AMP-binding enzyme family protein 0.0034 0.0334 0.0444
Trypanosoma cruzi hypothetical protein, conserved 0.0039 0.0402 0.2458
Onchocerca volvulus 0.0018 0.0082 0.0151
Schistosoma mansoni hypothetical protein 0.005 0.0574 0.0564
Trichomonas vaginalis heat shock protein, putative 0.0052 0.0609 0.0822
Loa Loa (eye worm) hypothetical protein 0.0034 0.0322 0.0428
Loa Loa (eye worm) acetyltransferase 0.0161 0.2274 0.3105
Mycobacterium ulcerans fatty acid synthase Fas 0.0033 0.0317 0.0858
Mycobacterium tuberculosis Probable dehydrogenase 0.0204 0.2934 0.8146
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Loa Loa (eye worm) MH2 domain-containing protein 0.0208 0.2987 0.4083
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Echinococcus granulosus tar DNA binding protein 0.0068 0.0853 0.0853
Mycobacterium tuberculosis P-hydroxybenzoyl-AMP ligase FadD22 0.0024 0.0174 0.0483
Loa Loa (eye worm) fatty acid synthase 0.0104 0.1406 0.1914
Schistosoma mansoni cpg binding protein 0.0027 0.0216 0.0206
Giardia lamblia Histone acetyltransferase GCN5 0.0043 0.0473 0.1139
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Mycobacterium leprae Probable cytosol aminopeptidase PepB 0.0117 0.1604 0.4886
Brugia malayi Steroid receptor seven-up type 2 0.0018 0.0078 0.0092
Echinococcus granulosus heat shock protein 75 kDa mitochondrial 0.0035 0.0341 0.0341
Echinococcus multilocularis NADP dependent isocitrate dehydrogenase 0.0016 0.0058 0.0058
Trypanosoma cruzi hypothetical protein, conserved 0.0018 0.0081 0.0442
Onchocerca volvulus 0.0098 0.1308 0.2752
Echinococcus multilocularis dnaJ subfamily B 0.038 0.562 0.562
Loa Loa (eye worm) aminopeptidase in chromosome III 0.0023 0.0166 0.0214
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Plasmodium falciparum glutathione reductase 0.0031 0.0283 0.0963
Schistosoma mansoni cellular tumor antigen P53 0.0045 0.049 0.048
Mycobacterium tuberculosis Probable medium chain fatty-acid-CoA ligase FadD14 (fatty-acid-CoA synthetase) (fatty-acid-CoA synthase) 0.0013 0.001 0.0029
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsD 0.0106 0.1427 0.3866
Leishmania major aminopeptidase, putative,metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Onchocerca volvulus 0.0039 0.0402 0.0831
Echinococcus multilocularis nuclear receptor 2DBD gamma 0.0018 0.0078 0.0078
Plasmodium falciparum AP endonuclease (DNA-[apurinic or apyrimidinic site] lyase), putative 0.0015 0.0041 0.0109
Echinococcus granulosus beta LACTamase domain containing family member 0.0039 0.0402 0.0402
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Toxoplasma gondii type I fatty acid synthase, putative 0.0075 0.0961 0.3354
Echinococcus granulosus survival motor neuron protein 1 0.0481 0.716 0.716
Mycobacterium ulcerans flavoprotein disulfide reductase 0.0031 0.0283 0.0767
Echinococcus granulosus dnaJ subfamily B 0.038 0.562 0.562
Schistosoma mansoni methyltransferase-related 0.0032 0.0296 0.0286
Brugia malayi calcium-independent alpha-latrotoxin receptor 2, putative 0.005 0.0574 0.0773
Leishmania major 2-oxoglutarate dehydrogenase, e3 component, lipoamidedehydrogenase-like protein 0.0031 0.0283 0.1712
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Onchocerca volvulus Protein ultraspiracle homolog 0.0018 0.0078 0.0142
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Toxoplasma gondii isocitrate dehydrogenase 0.0016 0.0058 0.0167
Mycobacterium ulcerans long-chain-fatty-acid--CoA ligase 0.0045 0.0496 0.1344
Schistosoma mansoni gcn5proteinral control of amino-acid synthesis 5-like 2 gcnl2 0.0161 0.2274 0.2266
Loa Loa (eye worm) RNA binding protein 0.0068 0.0853 0.1156
Echinococcus multilocularis hepatocyte nuclear factor 4 alpha 0.0018 0.0078 0.0078
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Loa Loa (eye worm) cysteine protease 0.0018 0.0082 0.0098
Trypanosoma brucei heat shock protein 90, putative 0.0052 0.0609 0.3759
Onchocerca volvulus 0.0018 0.0082 0.0151
Brugia malayi Ligand-binding domain of nuclear hormone receptor family protein 0.0018 0.0078 0.0092
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0609 0.3759
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Brugia malayi exodeoxyribonuclease III family protein 0.0015 0.0041 0.0042
Loa Loa (eye worm) hypothetical protein 0.0086 0.1131 0.1537
Brugia malayi acetyltransferase, GNAT family protein 0.0161 0.2274 0.3105
Mycobacterium ulcerans polyketide synthase 0.0106 0.1427 0.3866
Loa Loa (eye worm) TAR-binding protein 0.0068 0.0853 0.1156
Mycobacterium leprae PROBABLE FATTY-ACID-CoA LIGASE FADD2 (FATTY-ACID-CoA SYNTHETASE) (FATTY-ACID-CoA SYNTHASE) 0.0045 0.0496 0.1512
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Leishmania major heat shock protein, putative 0.0035 0.0341 0.2072
Schistosoma mansoni histone-lysine n-methyltransferase suv9 0.0035 0.0339 0.0329
Mycobacterium tuberculosis Polyketide synthase Pks13 0.0158 0.2228 0.6187
Loa Loa (eye worm) heat shock protein 90 0.0052 0.0609 0.0822
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0166 0.0166
Loa Loa (eye worm) Smad1 0.0014 0.0025 0.002
Schistosoma mansoni smad 0.0014 0.0025 0.0015
Loa Loa (eye worm) heat shock protein 75 0.0035 0.0341 0.0453
Mycobacterium tuberculosis NAD(P)H quinone reductase LpdA 0.0227 0.3283 0.9115
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Mycobacterium tuberculosis Probable nitrite reductase [NAD(P)H] large subunit [FAD flavoprotein] NirB 0.0204 0.2934 0.8146
Brugia malayi steroid hormone receptor 0.0018 0.0078 0.0092
Mycobacterium ulcerans dihydrolipoamide dehydrogenase, LpdB 0.0031 0.0283 0.0767
Trichomonas vaginalis bromodomain-containing protein, putative 0.0047 0.0534 0.0718
Mycobacterium ulcerans hypothetical protein 0.0018 0.0081 0.0219
Schistosoma mansoni cpg binding protein 0.0028 0.024 0.023
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0686 0.4239
Loa Loa (eye worm) beta-lactamase 0.0039 0.0402 0.0537
Loa Loa (eye worm) hypothetical protein 0.0034 0.0322 0.0428
Brugia malayi Endoplasmin precursor 0.0052 0.0609 0.0822
Trichomonas vaginalis heat shock protein, putative 0.0045 0.0494 0.0663
Brugia malayi oxidoreductase, short chain dehydrogenase/reductase family protein 0.0024 0.0174 0.0224
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0115 0.157 0.9788
Schistosoma mansoni PwLAP aminopeptidase (M17 family) 0.0023 0.0166 0.0156
Loa Loa (eye worm) hypothetical protein 0.005 0.0574 0.0773
Trypanosoma cruzi heat shock protein 85, putative 0.0052 0.0609 0.3759
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Mycobacterium ulcerans polyketide synthase Pks13 0.0158 0.2228 0.6034
Mycobacterium ulcerans acyl-CoA synthetase 0.0024 0.0174 0.0471
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0853 0.0843
Loa Loa (eye worm) nuclear hormone receptor family member nhr-49 0.0018 0.0078 0.0092
Mycobacterium ulcerans polyketide synthase Pks9 0.007 0.0879 0.2381
Onchocerca volvulus 0.0045 0.0496 0.1031
Mycobacterium tuberculosis Probable polyketide synthase Pks15 0.0043 0.0463 0.1286
Schistosoma mansoni hypothetical protein 0.0219 0.316 0.3153
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Loa Loa (eye worm) acyl carrier protein 0.0049 0.0553 0.0744
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Mycobacterium leprae Polyketide synthase Pks13 0.0158 0.2228 0.6787
Echinococcus multilocularis Smad4 0.0014 0.0025 0.0025
Mycobacterium tuberculosis Fatty-acid-CoA synthetase FadD17 (fatty-acid-CoA synthase) (fatty-acid-CoA ligase) 0.0013 0.001 0.0029
Leishmania major DNA polymerase kappa, putative 0.0018 0.0081 0.0442
Loa Loa (eye worm) hypothetical protein 0.018 0.2556 0.3492
Schistosoma mansoni Tr4/Tr2 (homologue) 0.0018 0.0078 0.0067
Schistosoma mansoni NADP-specific isocitrate dehydrogenase 0.0016 0.0058 0.0047
Trypanosoma brucei DNA polymerase IV, putative 0.0057 0.0686 0.4239
Mycobacterium tuberculosis Conserved protein 0.0032 0.0296 0.0822
Mycobacterium leprae PROBABLE NADH DEHYDROGENASE NDH 0.0204 0.2934 0.8938
Trypanosoma cruzi trypanothione reductase, putative 0.009 0.1179 0.7331
Plasmodium vivax dihydrolipoyl dehydrogenase, mitochondrial, putative 0.0031 0.0283 0.0963
Echinococcus multilocularis Basic leucine zipper (bZIP) transcription 0.0072 0.0916 0.0916
Echinococcus granulosus heat shock protein 90 0.0045 0.0494 0.0494
Schistosoma mansoni RAR-like nuclear receptor 0.0018 0.0078 0.0067
Brugia malayi Beta-ketoacyl synthase, N-terminal domain containing protein 0.0027 0.0215 0.028
Echinococcus granulosus smad 0.0014 0.0025 0.0025
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSD 0.0106 0.1427 0.4348
Trypanosoma brucei dihydrolipoamide dehydrogenase, point mutation 0.0031 0.0283 0.1712
Trypanosoma brucei Heat shock protein 83, putative 0.0052 0.0609 0.3759
Onchocerca volvulus Fatty acid synthase homolog 0.0191 0.2727 0.5763
Echinococcus granulosus leucyl aminopeptidase 0.0023 0.0166 0.0166
Trypanosoma brucei apurinic/apyrimidinic endonuclease, putative 0.0015 0.0041 0.0194
Schistosoma mansoni family S12 unassigned peptidase (S12 family) 0.0039 0.0402 0.0392
Brugia malayi hypothetical protein 0.0072 0.0916 0.1242
Trichomonas vaginalis fructose-bisphosphate aldolase, putative 0.0263 0.3834 0.5244
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Chlamydia trachomatis cytosol aminopeptidase 0.0117 0.1604 1
Schistosoma mansoni rab geranylgeranyl transferase alpha subunit 0.0057 0.0686 0.0676
Toxoplasma gondii beta-ketoacyl synthase, N-terminal domain-containing protein 0.0069 0.0859 0.2993
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Onchocerca volvulus 0.0018 0.0078 0.0142
Mycobacterium ulcerans acyl-CoA synthetase 0.0013 0.001 0.0028
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Leishmania major cysteine peptidase A (CPA) 0.0018 0.0082 0.0447
Echinococcus multilocularis heat shock protein 90 0.0052 0.0609 0.0609
Mycobacterium leprae Probable lipase LipE 0.0039 0.0402 0.1225
Echinococcus multilocularis dna polymerase kappa 0.0057 0.0686 0.0686
Loa Loa (eye worm) pigment dispersing factor receptor c 0.0158 0.2228 0.3042
Mycobacterium ulcerans fatty-acid-CoA ligase 0.0045 0.0496 0.1344
Entamoeba histolytica hypothetical protein 0.0072 0.0916 0.2389
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0064
Mycobacterium leprae PHENOLPTHIOCEROL SYNTHESIS TYPE-I POLYKETIDE SYNTHASE PPSC 0.0112 0.1528 0.4654
Echinococcus multilocularis leucyl aminopeptidase 0.0023 0.0166 0.0166
Trypanosoma cruzi metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Onchocerca volvulus 0.0156 0.2193 0.463
Echinococcus multilocularis survival motor neuron protein 1 0.0481 0.716 0.716
Brugia malayi beta-lactamase family protein 0.0039 0.0402 0.0537
Trichomonas vaginalis heat shock protein, putative 0.0049 0.056 0.0754
Entamoeba histolytica 90 kDa heat shock protein, putative 0.0035 0.0341 0.0888
Trypanosoma brucei unspecified product 0.0057 0.0686 0.4239
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.01 0.1333 0.1333
Mycobacterium ulcerans Type I modular polyketide synthase 0.0106 0.1427 0.3866
Loa Loa (eye worm) glutaminase 0.0254 0.3692 0.5051
Trypanosoma cruzi heat shock protein 90, putative 0.0022 0.0144 0.0837
Schistosoma mansoni transcription factor LCR-F1 0.0072 0.0916 0.0907
Brugia malayi O-Glycosyl hydrolase family 30 protein 0.049 0.7301 1
Echinococcus multilocularis beta LACTamase domain containing family member 0.0039 0.0402 0.0402
Brugia malayi alpha keto acid dehydrogenase complex, E3 component, lipoamide dehydrogenase 0.0023 0.0157 0.0201
Trichomonas vaginalis Clan CA, family C1, cathepsin L-like cysteine peptidase 0.0018 0.0082 0.0098
Brugia malayi cytosol aminopeptidase 0.0023 0.0166 0.0214
Trichomonas vaginalis DNA polymerase IV / kappa, putative 0.0057 0.0686 0.0926
Loa Loa (eye worm) nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0092
Schistosoma mansoni tar DNA-binding protein 0.0068 0.0853 0.0843
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Trypanosoma cruzi dihydrolipoamide dehydrogenase, putative 0.0031 0.0283 0.1712
Onchocerca volvulus 0.0045 0.049 0.1017
Schistosoma mansoni microtubule-associated protein tau 0.0666 1 1
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0117 0.1604 1
Mycobacterium ulcerans phenolpthiocerol synthesis type-I polyketide synthase PpsB 0.0085 0.1111 0.3009
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Leishmania major cathepsin L-like protease 0.0068 0.0849 0.5266
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0283 0.1712
Brugia malayi Nuclear hormone receptor family member nhr-41 0.0018 0.0078 0.0092
Echinococcus multilocularis tar DNA binding protein 0.0068 0.0853 0.0853
Toxoplasma gondii AMP-binding enzyme domain-containing protein 0.0055 0.0655 0.2274
Mycobacterium tuberculosis Phenyloxazoline synthase MbtB (phenyloxazoline synthetase) 0.0112 0.1523 0.4229
Echinococcus granulosus terminal deoxycytidyl transferase rev1 0.0057 0.0686 0.0686
Trypanosoma cruzi DNA damage repair protein, putative 0.0018 0.0081 0.0442
Schistosoma mansoni cathepsin F (C01 family) 0.0018 0.0082 0.0071
Plasmodium falciparum glutathione reductase 0.009 0.1179 0.4122
Trypanosoma brucei heat shock protein, putative 0.0052 0.0609 0.3759
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Loa Loa (eye worm) hypothetical protein 0.0016 0.0057 0.0064
Brugia malayi Smad1 0.0014 0.0025 0.002
Trypanosoma cruzi cysteine peptidase, putative 0.0068 0.0849 0.5266
Brugia malayi Aminopeptidase W07G4.4 in chromosome V 0.0023 0.0166 0.0214
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Trypanosoma brucei metallo-peptidase, Clan MF, Family M17 0.0023 0.0166 0.0978
Entamoeba histolytica heat shock protein 90, putative 0.0052 0.0609 0.159
Schistosoma mansoni FTZ-F1 nuclear receptor-like protein 0.0018 0.0078 0.0067
Onchocerca volvulus 0.0039 0.0402 0.0831
Mycobacterium tuberculosis Probable conserved lipoprotein 0.0039 0.0402 0.1117
Trichomonas vaginalis glucosylceramidase, putative 0.0321 0.4724 0.6466
Echinococcus granulosus cathepsin L cysteine proteinase 0.0018 0.0082 0.0082
Mycobacterium ulcerans leucyl aminopeptidase 0.0117 0.1604 0.4344
Loa Loa (eye worm) aminopeptidase in chromosome V 0.0023 0.0166 0.0214
Mycobacterium ulcerans aldehyde dehydrogenase 0.0115 0.157 0.4252
Mycobacterium tuberculosis Putative ferredoxin reductase 0.0204 0.2934 0.8146
Giardia lamblia Heat shock protein HSP 90-alpha 0.0045 0.0494 0.1193
Mycobacterium leprae PROBABLE CHAPERONE PROTEIN HTPG (HEAT SHOCK PROTEIN) (HSP90 FAMILY PROTEIN) (HIGH TEMPERATURE PROTEIN G) 0.0049 0.056 0.1707
Mycobacterium leprae Probable multifunctional mycocerosic acid synthase membrane associated enzyme Mas 0.0112 0.1528 0.4654
Brugia malayi nuclear hormone receptor 0.0018 0.0078 0.0092
Brugia malayi beta-lactamase family protein 0.0039 0.0402 0.0537
Loa Loa (eye worm) CXXC zinc finger family protein 0.0027 0.0216 0.0283
Mycobacterium tuberculosis Probable aminopeptidase PepB 0.0117 0.1604 0.4453
Brugia malayi glutathione reductase 0.009 0.1179 0.1602
Echinococcus granulosus tumor protein p63 0.0304 0.4462 0.4462
Onchocerca volvulus 0.0039 0.0402 0.0831
Schistosoma mansoni DNA polymerase IV / kappa 0.0018 0.0081 0.007
Toxoplasma gondii cathepsin CPL 0.0018 0.0082 0.0252
Toxoplasma gondii leucyl aminopeptidase LAP 0.0117 0.1604 0.5623
Plasmodium falciparum dihydrolipoyl dehydrogenase, mitochondrial 0.0031 0.0283 0.0963
Trypanosoma cruzi DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Loa Loa (eye worm) hypothetical protein 0.0045 0.0496 0.0666
Onchocerca volvulus Glucosylceramidase homolog 0.0321 0.4724 1
Mycobacterium tuberculosis Probable lipase LipE 0.0039 0.0402 0.1117
Mycobacterium tuberculosis Polyketide synthetase MbtC (polyketide synthase) 0.0036 0.0365 0.1013
Plasmodium vivax glutathione reductase, putative 0.009 0.1179 0.4122
Mycobacterium tuberculosis Conserved hypothetical protein 0.0057 0.0686 0.1904
Trypanosoma brucei cysteine peptidase, Clan CA, family C1, Cathepsin L-like 0.0068 0.0849 0.5266
Entamoeba histolytica long-chain-fatty-acid--CoA ligase, putative 0.0013 0.001 0.0027
Echinococcus multilocularis atpase aaa+ type core atpase aaa type core 0.0656 0.9851 0.9851
Brugia malayi Thioredoxin reductase 0.009 0.1179 0.1602
Leishmania major heat shock protein 83-1 0.0052 0.0609 0.3759
Plasmodium vivax heat shock protein 90, putative 0.0035 0.0341 0.1165
Trypanosoma cruzi heat shock protein, putative 0.0035 0.0341 0.2072
Schistosoma mansoni hypothetical protein 0.0098 0.1308 0.1299
Trypanosoma brucei heat shock protein 84, putative 0.0035 0.0341 0.2072
Loa Loa (eye worm) hypothetical protein 0.0018 0.0078 0.0092
Loa Loa (eye worm) hypothetical protein 0.0158 0.2228 0.3042
Entamoeba histolytica acyl-coA synthetase, putative 0.0045 0.0496 0.1294
Mycobacterium tuberculosis Probable peptide synthetase Nrp (peptide synthase) 0.0024 0.0174 0.0483
Trypanosoma cruzi heat shock protein 90, putative 0.0045 0.0494 0.3033
Leishmania major hypothetical protein, conserved 0.0032 0.0296 0.1793
Entamoeba histolytica deoxycytidyl transferase, putative 0.0057 0.0686 0.1789
Trypanosoma brucei trypanothione reductase 0.009 0.1179 0.7331
Schistosoma mansoni ap endonuclease 0.0015 0.0041 0.0031
Leishmania major isocitrate dehydrogenase [NADP], mitochondrial precursor, putative 0.0016 0.0058 0.0297
Onchocerca volvulus 0.0197 0.2828 0.5978
Trypanosoma brucei DNA polymerase kappa, putative 0.0057 0.0686 0.4239
Plasmodium vivax heat shock protein, putative 0.0198 0.2844 1
Mycobacterium leprae DIHYDROLIPOAMIDE DEHYDROGENASE LPD (LIPOAMIDE REDUCTASE (NADH)) (LIPOYL DEHYDROGENASE) (DIHYDROLIPOYL DEHYDROGENASE) (DIAPHORASE 0.0227 0.3283 1
Plasmodium falciparum cysteine proteinase falcipain 2a 0.0018 0.0082 0.0252
Toxoplasma gondii aldehyde dehydrogenase 0.0115 0.157 0.5503
Loa Loa (eye worm) exodeoxyribonuclease III family protein 0.0015 0.0041 0.0042
Wolbachia endosymbiont of Brugia malayi 3-oxoacyl-ACP synthase 0.0027 0.0215 0.111
Schistosoma mansoni Smad4 0.0014 0.0025 0.0015
Brugia malayi AMP-binding enzyme family protein 0.0045 0.0496 0.0666
Brugia malayi RNA binding protein 0.0068 0.0853 0.1156
Trypanosoma cruzi dihydrolipoyl dehydrogenase, putative 0.0031 0.0283 0.1712
Schistosoma mansoni photoreceptor-specific nuclear receptor related 0.0018 0.0078 0.0067
Trypanosoma brucei aminopeptidase, putative 0.0023 0.0166 0.0978
Loa Loa (eye worm) hypothetical protein 0.0039 0.0402 0.0537
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1333 0.1333
Brugia malayi Cathepsin L-like precursor 0.0018 0.0082 0.0098
Toxoplasma gondii ABC1 family protein 0.0039 0.0402 0.1382
Schistosoma mansoni leucine aminopeptidase 0.0023 0.0166 0.0156
Loa Loa (eye worm) nuclear hormone receptor family member nhr-31 0.0018 0.0078 0.0092
Echinococcus granulosus FTZ F1 nuclear receptor protein 0.0018 0.0078 0.0078
Echinococcus granulosus histone acetyltransferase KAT2B 0.0157 0.2205 0.2205
Mycobacterium ulcerans glutaminase 0.0254 0.3692 1
Echinococcus granulosus cathepsin l cysteine peptidase 0.0018 0.0082 0.0082
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Echinococcus multilocularis dna polymerase eta 0.0086 0.1131 0.1131
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Trichomonas vaginalis Clan CA, family C1, papain-like cysteine peptidase 0.0018 0.0082 0.0098
Mycobacterium tuberculosis Probable NADH dehydrogenase Ndh 0.0204 0.2934 0.8146
Mycobacterium ulcerans thioesterase 0.0088 0.1157 0.3135
Loa Loa (eye worm) hypothetical protein 0.0481 0.716 0.9806
Echinococcus multilocularis cathepsin L cysteine protease 0.0018 0.0082 0.0082
Trichomonas vaginalis glucosylceramidase, putative 0.049 0.7301 1
Trypanosoma brucei DNA damage repair protein, putative 0.0018 0.0081 0.0442
Loa Loa (eye worm) fibroinase 0.0018 0.0082 0.0098
Mycobacterium ulcerans lipase LipD 0.0039 0.0402 0.1089
Mycobacterium tuberculosis Probable polyketide beta-ketoacyl synthase Pks3 0.0016 0.0057 0.0158
Mycobacterium tuberculosis Probable reductase 0.0204 0.2934 0.8146
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.01 0.1333 0.1333
Echinococcus multilocularis cathepsin l cysteine peptidase 0.0018 0.0082 0.0082
Plasmodium falciparum endoplasmin, putative 0.0038 0.039 0.1339
Schistosoma mansoni hypothetical protein 0.0338 0.4981 0.4976
Echinococcus multilocularis heat shock protein 75 kDa, mitochondrial 0.0035 0.0341 0.0341
Mycobacterium tuberculosis Polyketide synthase Pks2 0.0103 0.1378 0.3825

Activities

Activity type Activity value Assay description Source Reference
Activity (functional) = 0 % Induction of terminal cell differentiation in human HL60 cells assessed as inhibition of [3H]thymidine incorporation at 32.3 uM after 4 days by liquid scintillation ChEMBL. 7798955
Activity (functional) = 0 % Induction of terminal cell differentiation in human HL60 cells assessed as inhibition of [3H]thymidine incorporation at 16.2 uM after 4 days by liquid scintillation ChEMBL. 7798955
Activity (functional) = 0 % Induction of terminal cell differentiation in human HL60 cells assessed as inhibition of [3H]thymidine incorporation at 8.1 uM after 4 days by liquid scintillation ChEMBL. 7798955
Activity (functional) = 0 % Induction of terminal cell differentiation in human HL60 cells assessed as inhibition of [3H]thymidine incorporation at 4 uM after 4 days by liquid scintillation ChEMBL. 7798955
Activity (functional) = 3.5 % Induction of terminal cell differentiation in human HL60 cells at 4 uM after 4 days by NBT reduction assay ChEMBL. 7798955
Activity (functional) = 4.5 % Induction of cell differentiation in human HL60 cells assessed as alpha naphthyl esterase activity at 4 uM after 4 days ChEMBL. 7798955
Activity (functional) = 5 % Induction of terminal cell differentiation in human HL60 cells assessed as naphthol AS-D chloroacetate esterase activity at 4 uM after 4 days ChEMBL. 7798955
Activity (functional) = 5.5 % Induction of cell differentiation in human HL60 cells assessed as alpha naphthyl esterase activity at 8.1 uM after 4 days ChEMBL. 7798955
Activity (functional) = 5.5 % Induction of terminal cell differentiation in human HL60 cells assessed as naphthol AS-D chloroacetate esterase activity at 8.1 uM after 4 days ChEMBL. 7798955
Activity (functional) = 6.5 % Induction of terminal cell differentiation in human HL60 cells assessed as naphthol AS-D chloroacetate esterase activity at 16.2 uM after 4 days ChEMBL. 7798955
Activity (functional) = 7.4 % Induction of cell differentiation in human HL60 cells assessed as alpha naphthyl esterase activity at 16.2 uM after 4 days ChEMBL. 7798955
Activity (functional) = 8 % Induction of terminal cell differentiation in human HL60 cells at 8.1 uM after 4 days by NBT reduction assay ChEMBL. 7798955
Activity (functional) = 9 % Induction of terminal cell differentiation in human HL60 cells assessed as cell viability at 64.6 uM by trypan blue exclusion method ChEMBL. 7798955
Activity (functional) = 9 % Induction of terminal cell differentiation in human HL60 cells at 16.2 uM after 4 days by NBT reduction assay ChEMBL. 7798955
Activity (functional) = 14.5 % Induction of terminal cell differentiation in human HL60 cells assessed as naphthol AS-D chloroacetate esterase activity at 32.3 uM after 4 days ChEMBL. 7798955
Activity (functional) = 15.4 % Induction of terminal cell differentiation in human HL60 cells at 32.3 uM after 4 days by NBT reduction assay ChEMBL. 7798955
Activity (functional) = 24.3 % Induction of cell differentiation in human HL60 cells assessed as alpha naphthyl esterase activity at 32.3 uM after 4 days ChEMBL. 7798955
Activity (functional) = 78 % Induction of terminal cell differentiation in human HL60 cells assessed as cell viability at 32.3 uM by trypan blue exclusion method ChEMBL. 7798955
Activity (functional) = 93 % Induction of terminal cell differentiation in human HL60 cells assessed as cell viability at 16.2 uM by trypan blue exclusion method ChEMBL. 7798955
Activity (functional) = 95 % Induction of terminal cell differentiation in human HL60 cells assessed as cell viability at 8.1 uM by trypan blue exclusion method ChEMBL. 7798955
Activity (functional) = 98 % Induction of terminal cell differentiation in human HL60 cells assessed as cell viability at 4 uM by trypan blue exclusion method ChEMBL. 7798955
ED50 (functional) = 10 ug ml-1 Cytotoxicity against human ZR-75-1 cells ChEMBL. 7798955
ED50 (functional) = 18.7 ug ml-1 Cytotoxicity against human LNCAP cells ChEMBL. 7798955
ED50 (functional) = 5.2 uM Cytotoxicity against mouse P388 cells ChEMBL. 7798955
ED50 (functional) = 15.2 uM Cytotoxicity against human KB cells ChEMBL. 7798955
ED50 (functional) = 28.4 uM Cytotoxicity against human SK-MEL cells ChEMBL. 7798955
ED50 (functional) = 28.8 uM Cytotoxicity against human HT1080 cells ChEMBL. 7798955
ED50 (functional) = 28.8 uM Cytotoxicity against human Lu1 cells ChEMBL. 7798955
ED50 (functional) = 28.8 uM Cytotoxicity against human A431 cells ChEMBL. 7798955
ED50 (functional) = 30.4 uM Cytotoxicity against human Col2 cells ChEMBL. 7798955

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
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External resources for this compound

Bibliographic References

No literature references available for this target.

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