Detailed information for compound 1009202

Basic information

Technical information
  • Name: Unnamed compound
  • MW: 217.247 | Formula: C10H7N3OS
  • H donors: 0 H acceptors: 3 LogP: 2.31 Rotable bonds: 1
    Rule of 5 violations (Lipinski): 1
  • SMILES: Cc1nonc1c1nc2c(s1)cccc2
  • InChi: 1S/C10H7N3OS/c1-6-9(13-14-12-6)10-11-7-4-2-3-5-8(7)15-10/h2-5H,1H3
  • InChiKey: SVULFRORVOSVQX-UHFFFAOYSA-N  


Substructure search Similarity search

Network

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Synonyms

No synonyms found for this compound

Targets

Known targets for this compound

No curated genes were found associated with this compound

Predicted pathogen targets for this compound

By orthology
No druggable targets predicted by orthology data
By sequence similarity to non orthologous known druggable targets
No druggable targets predicted by sequence similarity
Obtained from network model

Ranking Plot

Putative Targets List

Species Potential target Raw Global Species
Leishmania major aldehyde dehydrogenase, mitochondrial precursor 0.0062 0.9728 1
Loa Loa (eye worm) hypothetical protein 0.0037 0.4247 0.272
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.6386 0.3893
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Giardia lamblia Ubiquitin carboxyl-terminal hydrolase 4 0.0037 0.4247 0.5
Trichomonas vaginalis conserved hypothetical protein 0.0037 0.4247 0.5
Echinococcus granulosus aldehyde dehydrogenase mitochondrial 0.0062 0.9728 0.9541
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Mycobacterium tuberculosis Probable aldehyde dehydrogenase 0.0062 0.9728 0.5
Plasmodium vivax ataxin-2 like protein, putative 0.0027 0.2098 0.5
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.4247 1
Brugia malayi hypothetical protein 0.0036 0.4082 0.4082
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Echinococcus granulosus ubiquitin specific protease 41 0.0037 0.4247 0.028
Loa Loa (eye worm) RNA binding protein 0.0063 1 1
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.4247 0.5
Echinococcus granulosus tar DNA binding protein 0.0063 1 1
Echinococcus granulosus ubiquitin carboxyl terminal hydrolase 8 0.0037 0.4247 0.028
Brugia malayi hypothetical protein 0.0027 0.2098 0.2098
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.6386 0.3893
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.6386 0.3893
Brugia malayi RNA recognition motif domain containing protein 0.0063 1 1
Loa Loa (eye worm) GTP-binding regulatory protein Gs alpha-S chain 0.0046 0.6386 0.5427
Schistosoma mansoni ubiquitin-specific peptidase 8 (C19 family) 0.0037 0.4247 0.028
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.6386 0.3893
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.9728 0.5
Brugia malayi TAR-binding protein 0.0063 1 1
Echinococcus multilocularis ubiquitin carboxyl terminal hydrolase 8 0.0037 0.4247 0.028
Loa Loa (eye worm) RNA recognition domain-containing protein domain-containing protein 0.0063 1 1
Schistosoma mansoni tar DNA-binding protein 0.0063 1 1
Leishmania major ubiquitin hydrolase, putative,cysteine peptidase, Clan CA, family C19, putative 0.0037 0.4247 0.2817
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.9728 0.9541
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.2098 0.5
Trichomonas vaginalis Clan CA, family C19, ubiquitin hydrolase-like cysteine peptidase 0.0037 0.4247 0.5
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.9728 0.5
Echinococcus granulosus Peptidase C19 ubiquitin carboxyl terminal hydrolase 2 0.0037 0.4247 0.028
Echinococcus multilocularis Peptidase C19, ubiquitin carboxyl terminal hydrolase 2 0.0037 0.4247 0.028
Trypanosoma cruzi ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.4247 1
Echinococcus multilocularis aldehyde dehydrogenase, mitochondrial 0.0062 0.9728 0.9541
Toxoplasma gondii aldehyde dehydrogenase 0.0062 0.9728 1
Plasmodium falciparum ataxin-2 like protein, putative 0.0027 0.2098 0.5
Schistosoma mansoni Guanine nucleotide-binding protein G(s) subunit alpha (Adenylate cyclase-stimulating G alpha protein) 0.0046 0.6386 0.3893
Entamoeba histolytica ubiquitin carboxyl-terminal hydrolase domain containing protein 0.0037 0.4247 1
Trypanosoma brucei ubiquitin carboxyl-terminal hydrolase, putative 0.0037 0.4247 1
Brugia malayi GTP-binding regulatory protein Gs alpha-S chain, putative 0.0046 0.6386 0.6386
Brugia malayi Ubiquitin carboxyl-terminal hydrolase family protein 0.0037 0.4247 0.4247
Echinococcus multilocularis tar DNA binding protein 0.0063 1 1
Schistosoma mansoni ubiquitin-specific peptidase 2 (C19 family) 0.0037 0.4247 0.028
Loa Loa (eye worm) TAR-binding protein 0.0063 1 1
Schistosoma mansoni aldehyde dehydrogenase 0.0062 0.9728 0.9541
Echinococcus multilocularis ubiquitin specific protease 41 0.0037 0.4247 0.028
Mycobacterium ulcerans aldehyde dehydrogenase 0.0062 0.9728 0.5
Echinococcus multilocularis guanine nucleotide binding protein G(s) subunit 0.0046 0.6386 0.3893
Echinococcus granulosus guanine nucleotide binding protein Gs subunit 0.0046 0.6386 0.3893

Activities

Activity type Activity value Assay description Source Reference
GI (functional) = 22 % Antitrypanosomal activity against Trypanosoma cruzi Tulahuen 2 assessed as inhibition of growth of epimastigotes at 25 uM after 5 days by MTT assay relative to control ChEMBL. 18706821

Phenotypes

Whole-cell/tissue/organism interactions

We have no records of whole-cell/tissue assays done with this compound What does this mean?

Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.

Annotated phenotypes:

We have no manually annotated phenotypes for this drug. What does this mean? / Care to help?
In TDR Targets, information about phenotypes that are caused by drugs, or by genetic manipulation of cells (e.g. gene knockouts or knockdowns) is manually curated from the literature. These descriptions help to describe the potential of the target for drug development. If no information is available for this gene or if the information is incomplete, this may mean that i) the papers containing this information either appeared after the curation effort for this organism was carried out or they were inadvertently missed by curators; or that ii) the curation effort for this organism has not yet started.
 
In any case, if you have information about papers containing relevant validation data for this target, please log in using your TDR Targets username and password and send them to us using the corresponding form in this page (only visible to registered users) or contact us.

External resources for this compound

Bibliographic References

No literature references available for this target.

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