Species | Potential target | Raw | Global | Species |
---|---|---|---|---|
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0032 | 0.2925 | 0.3897 |
Onchocerca volvulus | 0.0032 | 0.2925 | 0.5 | |
Echinococcus multilocularis | aldehyde dehydrogenase, mitochondrial | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | hypothetical protein | 0.0031 | 0.2821 | 0.3759 |
Mycobacterium tuberculosis | Probable aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Toxoplasma gondii | aldehyde dehydrogenase | 0.0072 | 1 | 0.5 |
Echinococcus granulosus | lamin dm0 | 0.0032 | 0.2925 | 0.2925 |
Schistosoma mansoni | 3-hydroxyacyl-CoA dehydrogenase | 0.0062 | 0.8244 | 0.7518 |
Echinococcus multilocularis | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.8244 | 0.8244 |
Echinococcus granulosus | lamin | 0.0032 | 0.2925 | 0.2925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Loa Loa (eye worm) | cytoplasmic intermediate filament protein | 0.0017 | 0.03 | 0.04 |
Echinococcus granulosus | intermediate filament protein | 0.0032 | 0.2925 | 0.2925 |
Echinococcus multilocularis | musashi | 0.0032 | 0.2925 | 0.2925 |
Mycobacterium ulcerans | aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Echinococcus granulosus | 3 hydroxyacyl coenzyme A dehydrogenase type 2 | 0.0062 | 0.8244 | 0.8244 |
Loa Loa (eye worm) | intermediate filament tail domain-containing protein | 0.0032 | 0.2925 | 0.3897 |
Leishmania major | aldehyde dehydrogenase, mitochondrial precursor | 0.0072 | 1 | 1 |
Echinococcus multilocularis | lamin | 0.0032 | 0.2925 | 0.2925 |
Brugia malayi | Intermediate filament tail domain containing protein | 0.0032 | 0.2925 | 0.3304 |
Schistosoma mansoni | aldehyde dehydrogenase | 0.0072 | 1 | 1 |
Brugia malayi | intermediate filament protein | 0.0032 | 0.2925 | 0.3304 |
Brugia malayi | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0062 | 0.8244 | 1 |
Loa Loa (eye worm) | 3-hydroxyacyl-CoA dehydrogenase type II | 0.0058 | 0.7505 | 1 |
Onchocerca volvulus | 0.0032 | 0.2925 | 0.5 | |
Echinococcus multilocularis | lamin dm0 | 0.0032 | 0.2925 | 0.2925 |
Loa Loa (eye worm) | intermediate filament protein | 0.0032 | 0.2925 | 0.3897 |
Many chemical entities in TDR Targets come from high-throughput screenings with whole cells or tissue samples, and not all assayed compounds have been tested against a single a single target protein, probably because they get ruled out during screening process. Even if these compounds may have not been of interest in the original screening, they may come as interesting leads for other screening assays. Furthermore, we may be able to propose drug-target associations using chemical similarities and network patterns.